{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:03:09Z","timestamp":1793502189471,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232066"],"award-info":[{"award-number":["7232066"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200111"],"award-info":[{"award-number":["82200111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Hospitals Authority Youth Program","award":["QML20230303"],"award-info":[{"award-number":["QML20230303"]}]},{"name":"Reform and Development Program of Beijing Institute of Respiratory Medicine","award":["Ggyfz202314, Ggyfz202416"],"award-info":[{"award-number":["Ggyfz202314, Ggyfz202416"]}]},{"name":"Reform and Development Program of Beijing Institute of Respiratory Medicine","award":["Ggyfz202330"],"award-info":[{"award-number":["Ggyfz202330"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06875-8","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:19:36Z","timestamp":1754644776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glucagon-like peptide-1 receptor agonists inhibit the progression of malignant pleural effusion in obese mice by regulating the metabolism of pleural effusion"],"prefix":"10.1186","volume":"23","author":[{"given":"Ming-Ming","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Feng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-5618","authenticated-orcid":false,"given":"Feng-Shuang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"6875_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/jrms.JRMS_242_19","volume":"24","author":"M Abudawood","year":"2019","unstructured":"Abudawood M. Diabetes and cancer: A comprehensive review. J Res Med Sci. 2019;24:94. https:\/\/doi.org\/10.4103\/jrms.JRMS_242_19.","journal-title":"J Res Med Sci"},{"key":"6875_CR2","doi-asserted-by":"publisher","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","volume":"133","author":"C Boutari","year":"2022","unstructured":"Boutari C, Mantzoros CS. A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to Rage on. Metabolism. 2022;133:155217. https:\/\/doi.org\/10.1016\/j.metabol.2022.155217.","journal-title":"Metabolism"},{"key":"6875_CR3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1001\/jamainternmed.2023.0015","volume":"183","author":"X Wang","year":"2023","unstructured":"Wang X, et al. Association of cardiovascular health with life expectancy free of cardiovascular disease, diabetes, cancer, and dementia in UK adults. JAMA Intern Med. 2023;183:340\u20139. https:\/\/doi.org\/10.1001\/jamainternmed.2023.0015.","journal-title":"JAMA Intern Med"},{"key":"6875_CR4","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1016\/S2213-8587(18)30150-5","volume":"6","author":"J Pearson-Stuttard","year":"2018","unstructured":"Pearson-Stuttard J, et al. Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment. Lancet Diabetes Endocrinol. 2018;6:e6\u201315. https:\/\/doi.org\/10.1016\/S2213-8587(18)30150-5.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"6875_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.7314\/apjcp.2016.17.1.105","volume":"17","author":"K Ozer","year":"2016","unstructured":"Ozer K, Horsanali MO, Gorgel SN, Ozbek E. Diabetes is an important risk factor for metastasis in Non- Muscle-Invasive bladder Cancer. Asian Pac J Cancer Prev. 2016;17:105\u20138. https:\/\/doi.org\/10.7314\/apjcp.2016.17.1.105.","journal-title":"Asian Pac J Cancer Prev"},{"key":"6875_CR6","doi-asserted-by":"publisher","first-page":"e13332","DOI":"10.1111\/eci.13332","volume":"50","author":"ZH Yi","year":"2020","unstructured":"Yi ZH, et al. Association between diabetes mellitus and lung cancer: Meta-analysis. Eur J Clin Invest. 2020;50:e13332. https:\/\/doi.org\/10.1111\/eci.13332.","journal-title":"Eur J Clin Invest"},{"key":"6875_CR7","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1158\/1055-9965.EPI-20-1245","volume":"30","author":"J Pearson-Stuttard","year":"2021","unstructured":"Pearson-Stuttard J, et al. Type 2 diabetes and cancer: an umbrella review of observational and Mendelian randomization studies. Cancer Epidemiol Biomarkers Prev. 2021;30:1218\u201328. https:\/\/doi.org\/10.1158\/1055-9965.EPI-20-1245.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"6875_CR8","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1002\/cncr.34928","volume":"129","author":"S Shen","year":"2023","unstructured":"Shen S, Chen Y, Carpio A, Chang C, Iyengar NM. Incidence, risk factors, and management of alpelisib-associated hyperglycemia in metastatic breast cancer. Cancer. 2023;129:3854\u201361. https:\/\/doi.org\/10.1002\/cncr.34928.","journal-title":"Cancer"},{"key":"6875_CR9","doi-asserted-by":"publisher","unstructured":"Li YR, Ro V, Tchou JC, Obesity. Metabolic syndrome, and breast cancer: from prevention to intervention. Curr Surg Rep. 2018;6. https:\/\/doi.org\/10.1007\/s40137-018-0204-y.","DOI":"10.1007\/s40137-018-0204-y"},{"key":"6875_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12:31\u201346. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1059.","journal-title":"Cancer Discov"},{"key":"6875_CR11","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1136\/thoraxjnl-2014-205285","volume":"69","author":"AO Clive","year":"2014","unstructured":"Clive AO, et al. Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score. Thorax. 2014;69:1098\u2013104. https:\/\/doi.org\/10.1136\/thoraxjnl-2014-205285.","journal-title":"Thorax"},{"key":"6875_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1055\/s-0043-1769092","volume":"44","author":"T Wong","year":"2023","unstructured":"Wong T, Fuld AD, Feller-Kopman DJ. Malignant pleural effusions in the era of immunotherapy and antiangiogenic therapy. Semin Respir Crit Care Med. 2023;44:447\u201353. https:\/\/doi.org\/10.1055\/s-0043-1769092.","journal-title":"Semin Respir Crit Care Med"},{"key":"6875_CR13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41585-023-00764-9","volume":"20","author":"A Saha","year":"2023","unstructured":"Saha A, Kolonin MG, DiGiovanni J. Obesity and prostate cancer - microenvironmental roles of adipose tissue. Nat Rev Urol. 2023;20:579\u201396. https:\/\/doi.org\/10.1038\/s41585-023-00764-9.","journal-title":"Nat Rev Urol"},{"key":"6875_CR14","doi-asserted-by":"publisher","unstructured":"McDowell SAC, et al. Obesity alters monocyte developmental trajectories to enhance metastasis. J Exp Med. 2023;220. https:\/\/doi.org\/10.1084\/jem.20220509.","DOI":"10.1084\/jem.20220509"},{"key":"6875_CR15","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","volume":"23","author":"JH Stern","year":"2016","unstructured":"Stern JH, Rutkowski JM, Scherer PE, Adiponectin. Leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 2016;23:770\u201384. https:\/\/doi.org\/10.1016\/j.cmet.2016.04.011.","journal-title":"Cell Metab"},{"key":"6875_CR16","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/nm.2492","volume":"17","author":"KM Nieman","year":"2011","unstructured":"Nieman KM, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498\u2013503. https:\/\/doi.org\/10.1038\/nm.2492.","journal-title":"Nat Med"},{"key":"6875_CR17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","volume":"140","author":"EJ Park","year":"2010","unstructured":"Park EJ, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140:197\u2013208. https:\/\/doi.org\/10.1016\/j.cell.2009.12.052.","journal-title":"Cell"},{"key":"6875_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ctrv.2018.08.004","volume":"70","author":"SM Samuel","year":"2018","unstructured":"Samuel SM, Varghese E, Varghese S, Busselberg D. Challenges and perspectives in the treatment of diabetes associated breast cancer. Cancer Treat Rev. 2018;70:98\u2013111. https:\/\/doi.org\/10.1016\/j.ctrv.2018.08.004.","journal-title":"Cancer Treat Rev"},{"key":"6875_CR19","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.cell.2018.03.055","volume":"173","author":"C Jang","year":"2018","unstructured":"Jang C, Chen L, Rabinowitz JD. Metabolomics and isotope tracing. Cell. 2018;173:822\u201337. https:\/\/doi.org\/10.1016\/j.cell.2018.03.055.","journal-title":"Cell"},{"key":"6875_CR20","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1007\/s00125-012-2592-3","volume":"55","author":"YS Lee","year":"2012","unstructured":"Lee YS, et al. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia. 2012;55:2456\u201368. https:\/\/doi.org\/10.1007\/s00125-012-2592-3.","journal-title":"Diabetologia"},{"key":"6875_CR21","doi-asserted-by":"publisher","unstructured":"McLean BA, Wong CK, Kaur KD, Seeley RJ, Drucker DJ. Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide. JCI Insight. 2021;6. https:\/\/doi.org\/10.1172\/jci.insight.153732.","DOI":"10.1172\/jci.insight.153732"},{"key":"6875_CR22","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ajpath.2019.10.008","volume":"190","author":"F Moschovaki Filippidou","year":"2020","unstructured":"Moschovaki Filippidou F, et al. Glucagon-Like Peptide-1 receptor agonism improves nephrotoxic serum nephritis by inhibiting T-Cell proliferation. Am J Pathol. 2020;190:400\u201311. https:\/\/doi.org\/10.1016\/j.ajpath.2019.10.008.","journal-title":"Am J Pathol"},{"key":"6875_CR23","doi-asserted-by":"publisher","first-page":"101641","DOI":"10.1016\/j.molmet.2022.101641","volume":"66","author":"BA McLean","year":"2022","unstructured":"McLean BA, Wong CK, Kabir MG, Drucker DJ. Glucagon-like Peptide-1 receptor Tie2\u2009+\u2009cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction. Mol Metab. 2022;66:101641. https:\/\/doi.org\/10.1016\/j.molmet.2022.101641.","journal-title":"Mol Metab"},{"key":"6875_CR24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1186\/s12885-023-11077-w","volume":"23","author":"B Ma","year":"2023","unstructured":"Ma B, et al. High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist. BMC Cancer. 2023;23:594. https:\/\/doi.org\/10.1186\/s12885-023-11077-w.","journal-title":"BMC Cancer"},{"key":"6875_CR25","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1093\/jnci\/djn325","volume":"100","author":"GT Stathopoulos","year":"2008","unstructured":"Stathopoulos GT, et al. A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. J Natl Cancer Inst. 2008;100:1464\u201376. https:\/\/doi.org\/10.1093\/jnci\/djn325.","journal-title":"J Natl Cancer Inst"},{"key":"6875_CR26","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1038\/s41467-022-34258-w","volume":"13","author":"Y Yan","year":"2022","unstructured":"Yan Y, et al. Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism. Nat Commun. 2022;13:6408. https:\/\/doi.org\/10.1038\/s41467-022-34258-w.","journal-title":"Nat Commun"},{"key":"6875_CR27","doi-asserted-by":"publisher","unstructured":"Lattau SSJ, et al. Plasma lipidomic profiling using mass spectrometry for multiple sclerosis diagnosis and disease activity stratification (LipidMS). Int J Mol Sci. 2024;25. https:\/\/doi.org\/10.3390\/ijms25052483.","DOI":"10.3390\/ijms25052483"},{"key":"6875_CR28","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults. N Engl J Med. 2003;348:1625\u201338. https:\/\/doi.org\/10.1056\/NEJMoa021423.","journal-title":"N Engl J Med"},{"key":"6875_CR29","doi-asserted-by":"publisher","first-page":"101043","DOI":"10.1016\/j.tranon.2021.101043","volume":"14","author":"SS Mayengbam","year":"2021","unstructured":"Mayengbam SS, Singh A, Pillai AD, Bhat MK. Influence of cholesterol on cancer progression and therapy. Transl Oncol. 2021;14:101043. https:\/\/doi.org\/10.1016\/j.tranon.2021.101043.","journal-title":"Transl Oncol"},{"key":"6875_CR30","doi-asserted-by":"publisher","first-page":"101178","DOI":"10.1016\/j.tranon.2021.101178","volume":"14","author":"A Deb","year":"2021","unstructured":"Deb A, Deshmukh B, Ramteke P, Bhati FK, Bhat MK, Resistin. A journey from metabolism to cancer. Transl Oncol. 2021;14:101178. https:\/\/doi.org\/10.1016\/j.tranon.2021.101178.","journal-title":"Transl Oncol"},{"key":"6875_CR31","doi-asserted-by":"publisher","first-page":"1237934","DOI":"10.3389\/fendo.2023.1237934","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang D, Liu YP. Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs. Front Endocrinol (Lausanne). 2023;14:1237934. https:\/\/doi.org\/10.3389\/fendo.2023.1237934.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"6875_CR32","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.clnu.2023.06.011","volume":"42","author":"H Qiu","year":"2023","unstructured":"Qiu H, et al. Amino acid metabolism in tumor: new shine in the fog? Clin Nutr. 2023;42:1521\u201330. https:\/\/doi.org\/10.1016\/j.clnu.2023.06.011.","journal-title":"Clin Nutr"},{"key":"6875_CR33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/bjc.2014.272","volume":"111","author":"G Cheng","year":"2014","unstructured":"Cheng G, et al. Profiling and targeting of cellular bioenergetics: Inhibition of pancreatic cancer cell proliferation. Br J Cancer. 2014;111:85\u201393. https:\/\/doi.org\/10.1038\/bjc.2014.272.","journal-title":"Br J Cancer"},{"key":"6875_CR34","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrc3601","volume":"13","author":"JR Goldenring","year":"2013","unstructured":"Goldenring JR. A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis. Nat Rev Cancer. 2013;13:813\u201320. https:\/\/doi.org\/10.1038\/nrc3601.","journal-title":"Nat Rev Cancer"},{"key":"6875_CR35","doi-asserted-by":"publisher","first-page":"8294","DOI":"10.7150\/thno.36256","volume":"9","author":"Z Zhu","year":"2019","unstructured":"Zhu Z, et al. The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42. Theranostics. 2019;9:8294\u2013311. https:\/\/doi.org\/10.7150\/thno.36256.","journal-title":"Theranostics"},{"key":"6875_CR36","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1017\/S0029665111000073","volume":"70","author":"EK Lund","year":"2011","unstructured":"Lund EK, Belshaw NJ, Elliott GO, Johnson IT. Recent advances in Understanding the role of diet and obesity in the development of colorectal cancer. Proc Nutr Soc. 2011;70:194\u2013204. https:\/\/doi.org\/10.1017\/S0029665111000073.","journal-title":"Proc Nutr Soc"},{"key":"6875_CR37","doi-asserted-by":"publisher","unstructured":"Wlodarczyk M, Nowicka G, Obesity DNA. Damage, and development of Obesity-Related diseases. Int J Mol Sci. 2019;20. https:\/\/doi.org\/10.3390\/ijms20051146.","DOI":"10.3390\/ijms20051146"},{"key":"6875_CR38","doi-asserted-by":"publisher","first-page":"e2400845","DOI":"10.1002\/advs.202400845","volume":"11","author":"J Li","year":"2024","unstructured":"Li J, et al. Mitochondria-Modulating liposomes reverse Radio-Resistance for colorectal Cancer. Adv Sci (Weinh). 2024;11:e2400845. https:\/\/doi.org\/10.1002\/advs.202400845.","journal-title":"Adv Sci (Weinh)"},{"key":"6875_CR39","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1038\/s41467-020-17512-x","volume":"11","author":"W Zhou","year":"2020","unstructured":"Zhou W, et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020;11:3811. https:\/\/doi.org\/10.1038\/s41467-020-17512-x.","journal-title":"Nat Commun"},{"key":"6875_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s13046-021-02134-y","volume":"40","author":"F Bottger","year":"2021","unstructured":"Bottger F, Valles-Marti A, Cahn L, Jimenez CR. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res. 2021;40:343. https:\/\/doi.org\/10.1186\/s13046-021-02134-y.","journal-title":"J Exp Clin Cancer Res"},{"key":"6875_CR41","doi-asserted-by":"publisher","first-page":"981547","DOI":"10.3389\/fonc.2022.981547","volume":"12","author":"T Maekawa","year":"2022","unstructured":"Maekawa T, Miyake T, Tani M, Uemoto S. Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment. Front Oncol. 2022;12:981547. https:\/\/doi.org\/10.3389\/fonc.2022.981547.","journal-title":"Front Oncol"},{"key":"6875_CR42","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s00125-023-05972-x","volume":"66","author":"C Skriver","year":"2023","unstructured":"Skriver C, et al. Potential preventive properties of GLP-1 receptor agonists against prostate cancer: a nationwide cohort study. Diabetologia. 2023;66:2007\u201316. https:\/\/doi.org\/10.1007\/s00125-023-05972-x.","journal-title":"Diabetologia"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06875-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06875-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06875-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:19:37Z","timestamp":1754644777000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06875-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6875"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06875-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were carried out in accordance with the ARRIVE guidelines, and animal protocols were approved by the Animal Welfare & Ethics Committee of Capital Medical University (No. AEEI-2021-290 and No. AEEI-2024-043).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"886"}}