{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:48:16Z","timestamp":1790765296618,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273670"],"award-info":[{"award-number":["82273670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06880-x","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:45:39Z","timestamp":1753191939000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation"],"prefix":"10.1186","volume":"23","author":[{"given":"Fangqing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingkun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-2009","authenticated-orcid":false,"given":"Jiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"6880_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209\u201318.","journal-title":"J Clin Invest"},{"key":"6880_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/hep.29113","volume":"66","author":"A Unalp-Arida","year":"2017","unstructured":"Unalp-Arida A, Ruhl CE. Liver fibrosis scores predict liver disease mortality in the United States population. Hepatology. 2017;66:84\u201395.","journal-title":"Hepatology"},{"key":"6880_CR3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/hep.32285","volume":"75","author":"SL Friedman","year":"2022","unstructured":"Friedman SL, Pinzani M. Hepatic fibrosis 2022: unmet needs and a blueprint for the future. Hepatology. 2022;75:473\u201388.","journal-title":"Hepatology"},{"key":"6880_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00795-003-0230-3","volume":"37","author":"H Senoo","year":"2004","unstructured":"Senoo H. Structure and function of hepatic stellate cells. Med Electron Microsc. 2004;37:3\u201315.","journal-title":"Med Electron Microsc"},{"key":"6880_CR5","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","volume":"4","author":"I Mederacke","year":"2013","unstructured":"Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, Pradere JP, Schwabe RF. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun. 2013;4:2823.","journal-title":"Nat Commun"},{"key":"6880_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/nrgastro.2013.244","volume":"11","author":"K Ray","year":"2014","unstructured":"Ray K. Liver: hepatic stellate cells hold the key to liver fibrosis. Nat Rev Gastroenterol Hepatol. 2014;11:74.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"6880_CR7","doi-asserted-by":"publisher","first-page":"7873","DOI":"10.3390\/ijms25147873","volume":"25","author":"H Akkiz","year":"2024","unstructured":"Akkiz H, Gieseler RK, Canbay A. Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells. Int J Mol Sci. 2024;25:7873.","journal-title":"Int J Mol Sci"},{"key":"6880_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cmet.2020.10.026","volume":"33","author":"P Trivedi","year":"2021","unstructured":"Trivedi P, Wang S, Friedman SL. The Power of plasticity-metabolic regulation of hepatic stellate cells. Cell Metab. 2021;33:242\u201357.","journal-title":"Cell Metab"},{"key":"6880_CR9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","volume":"14","author":"T Tsuchida","year":"2017","unstructured":"Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14:397\u2013411.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"6880_CR10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/hep.27645","volume":"62","author":"F O'Mahony","year":"2015","unstructured":"O\u2019Mahony F, Wroblewski K, O\u2019Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology. 2015;62:615\u201326.","journal-title":"Hepatology"},{"key":"6880_CR11","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","volume":"385","author":"BA Neuschwander-Tetri","year":"2015","unstructured":"Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385:956\u201365.","journal-title":"Lancet"},{"key":"6880_CR12","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1053\/j.gastro.2016.01.038","volume":"150","author":"V Ratziu","year":"2016","unstructured":"Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, Serfaty L, Romero-Gomez M, Boursier J, Abdelmalek M, Caldwell S, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-\u03b1 and -\u03b4, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016;150:1147-1159.e1145.","journal-title":"Gastroenterology"},{"key":"6880_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jcmgh.2017.04.007","volume":"4","author":"E Moran-Salvador","year":"2017","unstructured":"Moran-Salvador E, Mann J. Epigenetics and liver fibrosis. Cell Mol Gastroenterol Hepatol. 2017;4:125\u201334.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6880_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111302","volume":"122","author":"QQ Dong","year":"2024","unstructured":"Dong QQ, Yang Y, Tao H, Lu C, Yang JJ. m6A epitranscriptomic and epigenetic crosstalk in liver fibrosis: special emphasis on DNA methylation and non-coding RNAs. Cell Signal. 2024;122: 111302.","journal-title":"Cell Signal"},{"key":"6880_CR15","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4093\/dmj.2025.0195","volume":"49","author":"YJ Roh","year":"2025","unstructured":"Roh YJ, Kim H, Choi DW. Metabolic sparks in the liver: metabolic and epigenetic reprogramming in hepatic stellate cells activation and its implications for human metabolic diseases. Diabetes Metab J. 2025;49:368\u201385.","journal-title":"Diabetes Metab J"},{"key":"6880_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/hep.23334","volume":"51","author":"I Mannaerts","year":"2010","unstructured":"Mannaerts I, Nuytten NR, Rogiers V, Vanderkerken K, van Grunsven LA, Geerts A. Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo. Hepatology. 2010;51:603\u201314.","journal-title":"Hepatology"},{"key":"6880_CR17","doi-asserted-by":"publisher","first-page":"15713","DOI":"10.1073\/pnas.1522163112","volume":"112","author":"N Ding","year":"2015","unstructured":"Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015;112:15713\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6880_CR18","doi-asserted-by":"crossref","unstructured":"Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA: MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010, 138:705\u2013714, 714 e701\u2013704.","DOI":"10.1053\/j.gastro.2009.10.002"},{"key":"6880_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jcmgh.2018.09.005","volume":"7","author":"R Martin-Mateos","year":"2019","unstructured":"Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, et al. Enhancer of zeste homologue 2 inhibition attenuates TGF-beta dependent hepatic stellate cell activation and liver fibrosis. Cell Mol Gastroenterol Hepatol. 2019;7:197\u2013209.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6880_CR20","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.jhep.2023.06.019","volume":"79","author":"B Li","year":"2023","unstructured":"Li B, Yang Z, Mao F, Gong W, Su Q, Yang J, Liu B, Song Y, Jin J, Lu Y. Downregulation of microRNA-145a-5p promotes steatosis-to-NASH progression through upregulation of Nr4a2. J Hepatol. 2023;79:1096\u2013109.","journal-title":"J Hepatol"},{"key":"6880_CR21","doi-asserted-by":"publisher","first-page":"10993","DOI":"10.1038\/ncomms10993","volume":"7","author":"J Hyun","year":"2016","unstructured":"Hyun J, Wang S, Kim J, Rao KM, Park SY, Chung I, Ha CS, Kim SW, Yun YH, Jung Y. MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression. Nat Commun. 2016;7:10993.","journal-title":"Nat Commun"},{"key":"6880_CR22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jhep.2024.08.014","volume":"82","author":"J Markovic","year":"2025","unstructured":"Markovic J, Li RM, Khanal R, Peng Q, M\u00f6bus S, Yuan QG, Engel B, Taubert R, Vondran FWR, Bantel H, et al. Identification and functional validation of miR-190b-5p and miR-296\u20133p as novel therapeutic attenuators of liver fibrosis. J Hepatol. 2025;82:301\u201314.","journal-title":"J Hepatol"},{"key":"6880_CR23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cmet.2013.08.009","volume":"18","author":"H el Azzouzi","year":"2013","unstructured":"el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, et al. The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation. Cell Metab. 2013;18:341\u201354.","journal-title":"Cell Metab"},{"key":"6880_CR24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nm.3026","volume":"19","author":"X Wang","year":"2012","unstructured":"Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, Li D, Hou Z, Lv K, Kan G, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2012;19:93\u2013100.","journal-title":"Nat Med"},{"key":"6880_CR25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/nar\/gkn920","volume":"37","author":"YB Lee","year":"2009","unstructured":"Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB. Twist-1 regulates the miR-199a\/214 cluster during development. Nucleic Acids Res. 2009;37:123\u20138.","journal-title":"Nucleic Acids Res"},{"key":"6880_CR26","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1158\/0008-5472.CAN-12-3686","volume":"73","author":"E Penna","year":"2013","unstructured":"Penna E, Orso F, Cimino D, Vercellino I, Grassi E, Quaglino E, Turco E, Taverna D. miR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation. Cancer Res. 2013;73:4098\u2013111.","journal-title":"Cancer Res"},{"key":"6880_CR27","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1161\/CIRCRESAHA.119.315428","volume":"126","author":"R Nosalski","year":"2020","unstructured":"Nosalski R, Siedlinski M, Denby L, McGinnigle E, Nowak M, Cat AND, Medina-Ruiz L, Cantini M, Skiba D, Wilk G, et al. T-cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circ Res. 2020;126:988\u20131003.","journal-title":"Circ Res"},{"key":"6880_CR28","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41420-023-01608-6","volume":"9","author":"J Luo","year":"2023","unstructured":"Luo J, Song G, Chen N, Xie M, Niu X, Zhou S, Ji Y, Zhu X, Ma W, Zhang Q, Yu D. Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. Cell Death Discov. 2023;9:311.","journal-title":"Cell Death Discov"},{"key":"6880_CR29","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/hep.26768","volume":"59","author":"L Chen","year":"2014","unstructured":"Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014;59:1118\u201329.","journal-title":"Hepatology"},{"key":"6880_CR30","doi-asserted-by":"publisher","first-page":"G491","DOI":"10.1152\/ajpgi.00140.2015","volume":"309","author":"L Chen","year":"2015","unstructured":"Chen L, Chen R, Kemper S, Charrier A, Brigstock DR. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: role of exosomes in horizontal transfer of Twist1. Am J Physiol Gastrointest Liver Physiol. 2015;309:G491-499.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"6880_CR31","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1111\/cas.12730","volume":"106","author":"H Okada","year":"2015","unstructured":"Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S. Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. Cancer Sci. 2015;106:1143\u201352.","journal-title":"Cancer Sci"},{"key":"6880_CR32","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","volume":"18","author":"D Wang","year":"2019","unstructured":"Wang D, Tai PWL, Gao G. Adeno-associated virus vector as a platform for gene therapy delivery. Nat Rev Drug Discov. 2019;18:358\u201378.","journal-title":"Nat Rev Drug Discov"},{"key":"6880_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115936","volume":"228","author":"N Chen","year":"2024","unstructured":"Chen N, Luo J, Zhou T, Shou Y, Du C, Song G, Xu L, Zhao K, Jin Y, Li C, Yu D. Lysine beta-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease. Biochem Pharmacol. 2024;228: 115936.","journal-title":"Biochem Pharmacol"},{"key":"6880_CR34","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nprot.2015.017","volume":"10","author":"I Mederacke","year":"2015","unstructured":"Mederacke I, Dapito DH, Aff\u00f2 S, Uchinami H, Schwabe RF. High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers. Nat Protoc. 2015;10:305\u201315.","journal-title":"Nat Protoc"},{"key":"6880_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107837","volume":"26","author":"J Luo","year":"2023","unstructured":"Luo J, Ji Y, Chen N, Song G, Zhou S, Niu X, Yu D. Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter. iScience. 2023;26: 107837.","journal-title":"iScience"},{"key":"6880_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115182","volume":"203","author":"N Chen","year":"2022","unstructured":"Chen N, Luo J, Hou Y, Ji Y, Xie M, Song G, Yu D. miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer. Biochem Pharmacol. 2022;203: 115182.","journal-title":"Biochem Pharmacol"},{"key":"6880_CR37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","volume":"14","author":"J Mann","year":"2007","unstructured":"Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ. 2007;14:275\u201385.","journal-title":"Cell Death Differ"},{"key":"6880_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156111","volume":"11","author":"SM Kweon","year":"2016","unstructured":"Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt pathway stabilizes MeCP2 protein to repress PPAR-gamma in activation of hepatic stellate cells. PLoS ONE. 2016;11: e0156111.","journal-title":"PLoS ONE"},{"issue":"1398\u20131412","key":"6880_CR39","volume":"157","author":"E Moran-Salvador","year":"2019","unstructured":"Moran-Salvador E, Garcia-Macia M, Sivaharan A, Sabater L, Zaki MYW, Oakley F, Knox A, Page A, Luli S, Mann J, Mann DA. Fibrogenic activity of MECP2 is regulated by phosphorylation in hepatic stellate cells. Gastroenterology. 2019;157(1398\u20131412): e1399.","journal-title":"Gastroenterology"},{"key":"6880_CR40","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1136\/annrheumdis-2018-213022","volume":"77","author":"Y He","year":"2018","unstructured":"He Y, Tsou PS, Khanna D, Sawalha AH. Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts. Ann Rheum Dis. 2018;77:1208\u201318.","journal-title":"Ann Rheum Dis"},{"key":"6880_CR41","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1172\/JCI135536","volume":"130","author":"Z Ma","year":"2020","unstructured":"Ma Z, Li L, Livingston MJ, Zhang D, Mi Q, Zhang M, Ding HF, Huo Y, Mei C, Dong Z. p53\/microRNA-214\/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease. J Clin Invest. 2020;130:5011\u201326.","journal-title":"J Clin Invest"},{"key":"6880_CR42","doi-asserted-by":"publisher","unstructured":"Kim S, Shim S, Kwon J, Ryoo S, Byeon J, Hong J, Lee JH, Kwon YG, Kim JY, Kim YM. Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-\u03baB-responsive miR-214\u20133p deletion (Mar, https:\/\/doi.org\/10.1038\/s12276-024-01237-8, 2024). Exp Mol Med. 2024, 56:1682\u20131682.","DOI":"10.1038\/s12276-024-01237-8"},{"key":"6880_CR43","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1177\/0192623315573587","volume":"43","author":"T Izawa","year":"2015","unstructured":"Izawa T, Horiuchi T, Atarashi M, Kuwamura M, Yamate J. Anti-fibrotic role of miR-214 in thioacetamide-induced liver cirrhosis in rats. Toxicol Pathol. 2015;43:844\u201351.","journal-title":"Toxicol Pathol"},{"key":"6880_CR44","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41419-018-0752-1","volume":"9","author":"L Ma","year":"2018","unstructured":"Ma L, Yang X, Wei R, Ye T, Zhou JK, Wen M, Men R, Li P, Dong B, Liu L, et al. MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression. Cell Death Dis. 2018;9:718.","journal-title":"Cell Death Dis"},{"key":"6880_CR45","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.tig.2022.02.006","volume":"38","author":"C Diener","year":"2022","unstructured":"Diener C, Keller A, Meese E. Emerging concepts of miRNA therapeutics: from cells to clinic. Trends Genet. 2022;38:613\u201326.","journal-title":"Trends Genet"},{"key":"6880_CR46","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.3390\/ijms25031469","volume":"25","author":"AA Seyhan","year":"2024","unstructured":"Seyhan AA. Trials and tribulations of MicroRNA therapeutics. Int J Mol Sci. 2024;25:1469.","journal-title":"Int J Mol Sci"},{"key":"6880_CR47","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1080\/15548627.2020.1827779","volume":"17","author":"DH Lee","year":"2021","unstructured":"Lee DH, Park SH, Ahn J, Hong SP, Lee E, Jang YJ, Ha TY, Huh YH, Ha SY, Jeon TI, Jung CH. Mir214-3p and Hnf4a\/Hnf4alpha reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis. Autophagy. 2021;17:2415\u201331.","journal-title":"Autophagy"},{"key":"6880_CR48","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41392-020-00445-8","volume":"6","author":"X Zhang","year":"2021","unstructured":"Zhang X, Yuan S, Li H, Zhan J, Wang F, Fan J, Nie X, Wang Y, Wen Z, Chen Y, et al. The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Signal Transduct Target Ther. 2021;6:69.","journal-title":"Signal Transduct Target Ther"},{"key":"6880_CR49","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1158\/0008-5472.CAN-07-2488","volume":"68","author":"H Yang","year":"2008","unstructured":"Yang H, Kong W, He L, Zhao JJ, O\u2019Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008;68:425\u201333.","journal-title":"Cancer Res"},{"key":"6880_CR50","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbrc.2021.02.077","volume":"549","author":"SH Deng","year":"2021","unstructured":"Deng SH, Wu DM, Li L, Liu T, Zhang T, Li J, Yu Y, He M, Zhao YY, Han R, Xu Y. miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549. Biochem Biophys Res Commun. 2021;549:54\u201360.","journal-title":"Biochem Biophys Res Commun"},{"key":"6880_CR51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133785","volume":"5","author":"R Lakhia","year":"2020","unstructured":"Lakhia R, Yheskel M, Flaten A, Ramalingam H, Aboudehen K, Ferre S, Biggers L, Mishra A, Chaney C, Wallace DP, et al. Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression. JCI Insight. 2020;5: e133785.","journal-title":"JCI Insight"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06880-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06880-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06880-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:10:29Z","timestamp":1757272229000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06880-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6880"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06880-x","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Institutional Animal Care and Use Committee of Qingdao University (No. 20230901C577220240121151). All experimental procedures followed the approved guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent this manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"810"}}