{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:08:54Z","timestamp":1791770934120,"version":"4.3.4"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274167"],"award-info":[{"award-number":["82274167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["2023A1515010578"],"award-info":[{"award-number":["2023A1515010578"]}]},{"name":"the Science and Technology Project of Heyuan, China Social Development and Rural Science","award":["2023008"],"award-info":[{"award-number":["2023008"]}]},{"name":"the Project of Guangdong Administration of Traditional Chinese Medicine","award":["20232177"],"award-info":[{"award-number":["20232177"]}]},{"name":"Open Research Project of the Key Laboratory of Viral Pathogenesis & Infection Prevention and Control of the Ministry of Education","award":["2024VPPC-R01"],"award-info":[{"award-number":["2024VPPC-R01"]}]},{"name":"the Outstanding Innovative Talents Cultivation Funded Programs for Doctoral Students of Jinan University","award":["2021CXB023"],"award-info":[{"award-number":["2021CXB023"]}]},{"name":"Medical Joint Fund of Jinan University","award":["YXJC2024006"],"award-info":[{"award-number":["YXJC2024006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06905-5","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T15:26:57Z","timestamp":1758727617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer"],"prefix":"10.1186","volume":"23","author":[{"given":"Liang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-zhuo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-bing","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"1","key":"6905_CR1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41401-021-00752-y","volume":"43","author":"LW Ren","year":"2022","unstructured":"Ren LW, Li W, Zheng XJ, et al. Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle. Acta Pharmacol Sin. 2022;43(1):194\u2013208.","journal-title":"Acta Pharmacol Sin"},{"key":"6905_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021334","author":"D Meco","year":"2023","unstructured":"Meco D, Attin\u00e0 G, Mastrangelo S, Navarra P, Ruggiero A. Emerging perspectives on the antiparasitic mebendazole as a repurposed drug for the treatment of brain cancers. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24021334.","journal-title":"Int J Mol Sci"},{"key":"6905_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26175118","author":"HS Choi","year":"2021","unstructured":"Choi HS, Ko YS, Jin H, et al. Anticancer effect of benzimidazole derivatives, especially mebendazole, on triple-negative breast cancer (TNBC) and radiotherapy-resistant TNBC in vivo and in vitro. Molecules. 2021. https:\/\/doi.org\/10.3390\/molecules26175118.","journal-title":"Molecules"},{"issue":"2","key":"6905_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/sj.onc.1204062","volume":"20","author":"SS Bacus","year":"2001","unstructured":"Bacus SS, Gudkov AV, Lowe M, et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene. 2001;20(2):147\u201355.","journal-title":"Oncogene"},{"issue":"4","key":"6905_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nrc1317","volume":"4","author":"MA Jordan","year":"2004","unstructured":"Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004;4(4):253\u201365.","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"6905_CR6","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.7150\/thno.38729","volume":"10","author":"TM Chin","year":"2020","unstructured":"Chin TM, Boopathy GTK, Man EPS, et al. Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. Theranostics. 2020;10(6):2727\u201343.","journal-title":"Theranostics"},{"issue":"Pt 3","key":"6905_CR7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1017\/S003118200100124X","volume":"124","author":"MW Robinson","year":"2002","unstructured":"Robinson MW, Trudgett A, Hoey EM, Fairweather I. Triclabendazole-resistant Fasciola hepatica: Beta-tubulin and response to in vitro treatment with triclabendazole. Parasitology. 2002;124(Pt 3):325\u201338.","journal-title":"Parasitology"},{"key":"6905_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.670081","volume":"12","author":"L Yan","year":"2021","unstructured":"Yan L, Liu Y, Ma XF, et al. Triclabendazole induces pyroptosis by activating Caspase-3 to cleave GSDME in breast cancer cells. Front Pharmacol. 2021;12: 670081.","journal-title":"Front Pharmacol"},{"issue":"3","key":"6905_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","volume":"34","author":"NN Pavlova","year":"2022","unstructured":"Pavlova NN, Zhu J, Thompson CB. The hallmarks of cancer metabolism: still emerging. Cell Metab. 2022;34(3):355\u201377.","journal-title":"Cell Metab"},{"key":"6905_CR10","doi-asserted-by":"publisher","first-page":"15503","DOI":"10.1038\/ncomms15503","volume":"8","author":"J Goodwin","year":"2017","unstructured":"Goodwin J, Neugent ML, Lee SY, et al. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017;8:15503.","journal-title":"Nat Commun"},{"issue":"11","key":"6905_CR11","doi-asserted-by":"publisher","first-page":"a037838","DOI":"10.1101\/cshperspect.a037838","volume":"11","author":"GM DeNicola","year":"2021","unstructured":"DeNicola GM, Shackelford DB. Metabolic phenotypes, dependencies, and adaptation in lung cancer. Cold Spring Harb Perspect Med. 2021;11(11):a037838.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"11","key":"6905_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142162","volume":"10","author":"PA Stewart","year":"2015","unstructured":"Stewart PA, Parapatics K, Welsh EA, et al. A pilot proteogenomic study with data integration identifies MCT1 and GLUT1 as prognostic markers in lung adenocarcinoma. PLoS ONE. 2015;10(11): e0142162.","journal-title":"PLoS ONE"},{"issue":"8","key":"6905_CR13","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.7150\/thno.53347","volume":"11","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Li F, Gao B, et al. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. Theranostics. 2021;11(8):3868\u201381.","journal-title":"Theranostics"},{"issue":"1","key":"6905_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12964-024-01678-8","volume":"22","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Li Y, Chen S, et al. GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma. Cell Commun Signal. 2024;22(1):303.","journal-title":"Cell Commun Signal"},{"issue":"2","key":"6905_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bbcan.2019.02.003","volume":"1871","author":"S Amin","year":"2019","unstructured":"Amin S, Yang P, Li Z. Pyruvate kinase M2: a multifarious enzyme in non-canonical localization to promote cancer progression. Biochim Biophys Acta Rev Cancer. 2019;1871(2):331\u201341.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"3","key":"6905_CR16","doi-asserted-by":"publisher","first-page":"172","DOI":"10.2174\/1566524019666190424131704","volume":"19","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou L, Zhou K, et al. Celastrol protects RPE cells from oxidative stress-induced cell death via activation of Nrf2 signaling pathway. Curr Mol Med. 2019;19(3):172\u201382.","journal-title":"Curr Mol Med"},{"issue":"7","key":"6905_CR17","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/cac2.12158","volume":"41","author":"JZ Wang","year":"2021","unstructured":"Wang JZ, Zhu W, Han J, et al. The role of the HIF-1\u03b1\/ALYREF\/PKM2 axis in glycolysis and tumorigenesis of bladder cancer. Cancer Commun (Lond). 2021;41(7):560\u201375.","journal-title":"Cancer Commun (Lond)"},{"issue":"7375","key":"6905_CR18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature10598","volume":"480","author":"W Yang","year":"2011","unstructured":"Yang W, Xia Y, Ji H, et al. Nuclear PKM2 regulates \u03b2-catenin transactivation upon EGFR activation. Nature. 2011;480(7375):118\u201322.","journal-title":"Nature"},{"issue":"1","key":"6905_CR19","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1038\/s41467-019-11662-3","volume":"10","author":"Y Fang","year":"2019","unstructured":"Fang Y, Shen ZY, Zhan YZ, et al. CD36 inhibits \u03b2-catenin\/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis. Nat Commun. 2019;10(1):3981.","journal-title":"Nat Commun"},{"issue":"11","key":"6905_CR20","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1016\/j.apsb.2021.03.021","volume":"11","author":"X Wu","year":"2021","unstructured":"Wu X, Liu L, Zheng Q, et al. Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2. Acta Pharm Sin B. 2021;11(11):3553\u201366.","journal-title":"Acta Pharm Sin B"},{"issue":"6","key":"6905_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03782-w","volume":"12","author":"F Gao","year":"2021","unstructured":"Gao F, Zhang X, Wang S, et al. TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation. Cell Death Dis. 2021;12(6): 517.","journal-title":"Cell Death Dis"},{"issue":"8","key":"6905_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101684","volume":"5","author":"B Lian","year":"2024","unstructured":"Lian B, Zhang J, Yin X, et al. SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2. Cell Rep Med. 2024;5(8): 101684.","journal-title":"Cell Rep Med"},{"issue":"13","key":"6905_CR23","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1158\/0008-5472.CAN-15-2498","volume":"76","author":"SH Park","year":"2016","unstructured":"Park SH, Ozden O, Liu G, et al. SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth. Cancer Res. 2016;76(13):3802\u201312.","journal-title":"Cancer Res"},{"issue":"7","key":"6905_CR24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41419-022-05051-w","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Wang G, Han K, et al. Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia\/reperfusion injury. Cell Death Dis. 2022;13(7):594.","journal-title":"Cell Death Dis"},{"key":"6905_CR25","doi-asserted-by":"publisher","first-page":"105274","DOI":"10.1016\/j.phrs.2020.105274","volume":"163","author":"S Pulya","year":"2021","unstructured":"Pulya S, Amin SA, Adhikari N, et al. HDAC6 as privileged target in drug discovery: a perspective. Pharmacol Res. 2021;163:105274.","journal-title":"Pharmacol Res"},{"issue":"6887","key":"6905_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/417455a","volume":"417","author":"C Hubbert","year":"2002","unstructured":"Hubbert C, Guardiola A, Shao R, et al. HDAC6 is a microtubule-associated deacetylase. Nature. 2002;417(6887):455\u20138.","journal-title":"Nature"},{"issue":"5","key":"6905_CR27","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","volume":"18","author":"JJ Kovacs","year":"2005","unstructured":"Kovacs JJ, Murphy PJ, Gaillard S, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005;18(5):601\u20137.","journal-title":"Mol Cell"},{"issue":"15","key":"6905_CR28","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41388-023-02641-6","volume":"42","author":"B Liu","year":"2023","unstructured":"Liu B, Zhang J, Meng X, et al. HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer. Oncogene. 2023;42(15):1181\u201395.","journal-title":"Oncogene"},{"issue":"1","key":"6905_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13045-018-0654-9","volume":"11","author":"T Li","year":"2018","unstructured":"Li T, Zhang C, Hassan S, et al. Histone deacetylase 6 in cancer. J Hematol Oncol. 2018;11(1):111.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"6905_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00453-9","volume":"7","author":"O Wattanathamsan","year":"2021","unstructured":"Wattanathamsan O, Thararattanobon R, Rodsiri R, et al. Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization. Cell Death Discov. 2021;7(1): 67.","journal-title":"Cell Death Discov"},{"issue":"1","key":"6905_CR31","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/s41467-017-01024-2","volume":"8","author":"T Chen","year":"2017","unstructured":"Chen T, Li J, Xu M, et al. PKC\u03b5 phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation. Nat Commun. 2017;8(1):939.","journal-title":"Nat Commun"},{"issue":"1","key":"6905_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12943-018-0791-3","volume":"17","author":"MC Hsu","year":"2018","unstructured":"Hsu MC, Hung WC. Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling. Mol Cancer. 2018;17(1):35.","journal-title":"Mol Cancer"},{"issue":"1","key":"6905_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1073\/pnas.1311249111","volume":"111","author":"HJ Wang","year":"2014","unstructured":"Wang HJ, Hsieh YJ, Cheng WC, et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1\u03b1-mediated glucose metabolism. Proc Natl Acad Sci U S A. 2014;111(1):279\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"54","key":"6905_CR34","doi-asserted-by":"publisher","first-page":"eabb9561","DOI":"10.1126\/sciimmunol.abb9561","volume":"5","author":"TM Young","year":"2020","unstructured":"Young TM, Reyes C, Pasnikowski E, et al. Autophagy protects tumors from T cell-mediated cytotoxicity via inhibition of TNF\u03b1-induced apoptosis. Sci Immunol. 2020;5(54):eabb9561.","journal-title":"Sci Immunol."},{"issue":"18","key":"6905_CR35","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1056\/NEJMoa2027071","volume":"383","author":"YL Wu","year":"2020","unstructured":"Wu YL, Tsuboi M, He J, et al. Osimertinib in resected EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2020;383(18):1711\u201323.","journal-title":"N Engl J Med"},{"issue":"12","key":"6905_CR36","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1002\/cmdc.202100004","volume":"16","author":"CSW Law","year":"2021","unstructured":"Law CSW, Yeong KY. Benzimidazoles in drug discovery: a patent review. ChemMedChem. 2021;16(12):1861\u201377.","journal-title":"ChemMedChem"},{"issue":"9","key":"6905_CR37","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.2174\/1389557521666211001122118","volume":"22","author":"R Kumar","year":"2022","unstructured":"Kumar R, Singh C, Mazumder A, et al. Synthetic approach to potential anticancer benzimidazole derivatives: a review. Mini Rev Med Chem. 2022;22(9):1289\u2013304.","journal-title":"Mini Rev Med Chem"},{"issue":"7","key":"6905_CR38","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.pt.2020.04.005","volume":"36","author":"J de Moraes","year":"2020","unstructured":"de Moraes J, Geary TG. FDA-approved antiparasitic drugs in the 21st century: a success for helminthiasis? Trends Parasitol. 2020;36(7):573\u20135.","journal-title":"Trends Parasitol"},{"issue":"1","key":"6905_CR39","first-page":"7","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7\u201333.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"6905_CR40","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.molcel.2019.08.028","volume":"76","author":"PH Chen","year":"2019","unstructured":"Chen PH, Cai L, Huffman K, et al. Metabolic diversity in human non-small cell lung cancer cells. Mol Cell. 2019;76(5):838-851.e835.","journal-title":"Mol Cell"},{"issue":"5","key":"6905_CR41","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646\u201374.","journal-title":"Cell"},{"issue":"21","key":"6905_CR42","doi-asserted-by":"publisher","first-page":"8674","DOI":"10.1073\/pnas.1016627108","volume":"108","author":"T Cheng","year":"2011","unstructured":"Cheng T, Sudderth J, Yang C, et al. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc Natl Acad Sci U S A. 2011;108(21):8674\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6905_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102308","author":"JH Park","year":"2020","unstructured":"Park JH, Pyun WY, Park HW. Cancer metabolism: phenotype, signaling and therapeutic targets. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9102308.","journal-title":"Cells"},{"key":"6905_CR44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.canlet.2021.07.025","volume":"518","author":"S Lin","year":"2021","unstructured":"Lin S, Li Y, Wang D, et al. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett. 2021;518:230\u201342.","journal-title":"Cancer Lett"},{"issue":"9","key":"6905_CR45","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/s41419-023-06142-y","volume":"14","author":"Y Chen","year":"2023","unstructured":"Chen Y, Yan H, Yan L, et al. Hypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming. Cell Death Dis. 2023;14(9):617.","journal-title":"Cell Death Dis"},{"key":"6905_CR46","doi-asserted-by":"publisher","first-page":"114941","DOI":"10.1016\/j.bcp.2022.114941","volume":"198","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang Y, Li Y, et al. Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer. Biochem Pharmacol. 2022;198:114941.","journal-title":"Biochem Pharmacol"},{"issue":"1\u20132","key":"6905_CR47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11010-016-2927-3","volume":"428","author":"F Zhou","year":"2017","unstructured":"Zhou F, Du J, Wang J. Albendazole inhibits HIF-1\u03b1-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 2017;428(1\u20132):171\u20138.","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"6905_CR48","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10863-008-9148-8","volume":"40","author":"JG Pastorino","year":"2008","unstructured":"Pastorino JG, Hoek JB. Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr. 2008;40(3):171\u201382.","journal-title":"J Bioenerg Biomembr"},{"issue":"11","key":"6905_CR49","doi-asserted-by":"publisher","first-page":"4762","DOI":"10.7150\/thno.43839","volume":"10","author":"Q Hua","year":"2020","unstructured":"Hua Q, Mi B, Xu F, et al. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2\/HIF-1\u03b1 axis. Theranostics. 2020;10(11):4762\u201378.","journal-title":"Theranostics"},{"issue":"1","key":"6905_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02547-3","volume":"41","author":"Y Wu","year":"2022","unstructured":"Wu Y, Wang Y, Yao H, et al. MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation. J Exp Clin Cancer Res. 2022;41(1): 337.","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"6905_CR51","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.molcel.2013.09.004","volume":"52","author":"L Lv","year":"2013","unstructured":"Lv L, Xu YP, Zhao D, et al. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell. 2013;52(3):340\u201352.","journal-title":"Mol Cell"},{"issue":"1","key":"6905_CR52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40164-022-00295-w","volume":"11","author":"H Lei","year":"2022","unstructured":"Lei H, Yang L, Wang Y, et al. JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression. Exp Hematol Oncol. 2022;11(1):42.","journal-title":"Exp Hematol Oncol"},{"issue":"1","key":"6905_CR53","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.canlet.2008.08.016","volume":"277","author":"O Witt","year":"2009","unstructured":"Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: What are the cancer relevant targets? Cancer Lett. 2009;277(1):8\u201321.","journal-title":"Cancer Lett"},{"issue":"2","key":"6905_CR54","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molcel.2007.05.033","volume":"27","author":"X Zhang","year":"2007","unstructured":"Zhang X, Yuan Z, Zhang Y, et al. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007;27(2):197\u2013213.","journal-title":"Mol Cell"},{"issue":"15","key":"6905_CR55","doi-asserted-by":"publisher","first-page":"11219","DOI":"10.1074\/jbc.M109.042754","volume":"285","author":"YS Gao","year":"2010","unstructured":"Gao YS, Hubbert CC, Yao TP. The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010;285(15):11219\u201326.","journal-title":"J Biol Chem"},{"issue":"12","key":"6905_CR56","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41419-020-03212-3","volume":"11","author":"R Zhang","year":"2020","unstructured":"Zhang R, Shen M, Wu C, et al. HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma. Cell Death Dis. 2020;11(12):1036.","journal-title":"Cell Death Dis"},{"issue":"6","key":"6905_CR57","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","volume":"66","author":"D Garcia","year":"2017","unstructured":"Garcia D, Shaw RJ. AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell. 2017;66(6):789\u2013800.","journal-title":"Mol Cell"},{"issue":"2","key":"6905_CR58","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41581-022-00648-y","volume":"19","author":"C Huynh","year":"2023","unstructured":"Huynh C, Ryu J, Lee J, Inoki A, Inoki K. Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases. Nat Rev Nephrol. 2023;19(2):102\u201322.","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"6905_CR59","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1161\/CIRCRESAHA.119.316463","volume":"127","author":"K Veys","year":"2020","unstructured":"Veys K, Fan Z, Ghobrial M, et al. Role of the GLUT1 glucose transporter in postnatal CNS angiogenesis and blood-brain barrier integrity. Circ Res. 2020;127(4):466\u201382.","journal-title":"Circ Res"},{"key":"6905_CR60","doi-asserted-by":"publisher","first-page":"896904","DOI":"10.3389\/fonc.2022.896904","volume":"12","author":"F Bie","year":"2022","unstructured":"Bie F, Zhang G, Yan X, et al. \u03b2-Boswellic acid suppresses breast precancerous lesions via GLUT1 targeting-mediated glycolysis inhibition and AMPK pathway activation. Front Oncol. 2022;12:896904.","journal-title":"Front Oncol"},{"issue":"9","key":"6905_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3364","volume":"23","author":"W Chen","year":"2021","unstructured":"Chen W, Huang F, Huang J, et al. SLC45A4 promotes glycolysis and prevents AMPK\/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma. J Gene Med. 2021;23(9): e3364.","journal-title":"J Gene Med"},{"issue":"7","key":"6905_CR62","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41573-019-0019-2","volume":"18","author":"GR Steinberg","year":"2019","unstructured":"Steinberg GR, Carling D. AMP-activated protein kinase: the current landscape for drug development. Nat Rev Drug Discov. 2019;18(7):527\u201351.","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"6905_CR63","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1152\/physrev.00026.2020","volume":"101","author":"A Szwed","year":"2021","unstructured":"Szwed A, Kim E, Jacinto E. Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev. 2021;101(3):1371\u2013426.","journal-title":"Physiol Rev"},{"key":"6905_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050681","author":"CW Wu","year":"2021","unstructured":"Wu CW, Storey KB. mTOR signaling in metabolic stress adaptation. Biomolecules. 2021. https:\/\/doi.org\/10.3390\/biom11050681.","journal-title":"Biomolecules"},{"issue":"5","key":"6905_CR65","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.21037\/jgo-22-957","volume":"13","author":"H Yao","year":"2022","unstructured":"Yao H, Wang S, Zhou X, et al. STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway. J Gastrointest Oncol. 2022;13(5):2458\u201371.","journal-title":"J Gastrointest Oncol"},{"issue":"2","key":"6905_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1366-y","volume":"10","author":"S Jia","year":"2019","unstructured":"Jia S, Xu X, Zhou S, et al. Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways. Cell Death Dis. 2019;10(2): 142.","journal-title":"Cell Death Dis"},{"issue":"1","key":"6905_CR67","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41392-023-01367-x","volume":"8","author":"L Chen","year":"2023","unstructured":"Chen L, Zhang W, Chen D, et al. RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis. Signal Transduct Target Ther. 2023;8(1):159.","journal-title":"Signal Transduct Target Ther"},{"key":"6905_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154780","volume":"114","author":"T Yang","year":"2023","unstructured":"Yang T, Xiao Y, Liu S, et al. Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK\/mTOR\/p70S6K signaling pathway in doxorubicin-resistant breast cancer. Phytomedicine. 2023;114: 154780.","journal-title":"Phytomedicine"},{"issue":"7","key":"6905_CR69","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1080\/14787210.2021.1858798","volume":"19","author":"L Marcos","year":"2021","unstructured":"Marcos L, Maco V, Terashima A. Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures. Expert Rev Anti Infect Ther. 2021;19(7):817\u201323.","journal-title":"Expert Rev Anti Infect Ther"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06905-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06905-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06905-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:03:56Z","timestamp":1758733436000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06905-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6905"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06905-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1001"}}