{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:19Z","timestamp":1793900179802,"version":"4.8.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82060203 to L.S."],"award-info":[{"award-number":["No. 82060203 to L.S."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022957","name":"Double Thousand Plan of Jiangxi Province","doi-asserted-by":"publisher","award":["No. jxsq2023201045 to S.L."],"award-info":[{"award-number":["No. jxsq2023201045 to S.L."]}],"id":[{"id":"10.13039\/100022957","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-level and High-skilled Leading Talent Training Project of Jiangxi Province","award":["No. G\/Y3034 to S.L."],"award-info":[{"award-number":["No. G\/Y3034 to S.L."]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06925-1","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:56:58Z","timestamp":1754560618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multi-omics data reveal that SAA1\u2009+\u2009fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis"],"prefix":"10.1186","volume":"23","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"6925_CR1","doi-asserted-by":"publisher","unstructured":"Kinane DF, et al. Periodontal diseases. Nat Reviews Disease Primers. 2017;3(17038). https:\/\/doi.org\/10.1038\/nrdp.2017.38.","DOI":"10.1038\/nrdp.2017.38"},{"key":"6925_CR2","doi-asserted-by":"publisher","unstructured":"Darby I. Risk factors for periodontitis & peri-implantitis. Periodontology 2000 2022, 90(1):9\u201312. https:\/\/doi.org\/10.1111\/prd.12447","DOI":"10.1111\/prd.12447"},{"key":"6925_CR3","doi-asserted-by":"publisher","unstructured":"Herrera D et al. Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline. J Clin Periodontology 2022 49 Suppl 24:4\u201371, https:\/\/doi.org\/10.1111\/jcpe.13639","DOI":"10.1111\/jcpe.13639"},{"issue":"1","key":"6925_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/prd.12435","volume":"89","author":"F Teles","year":"2022","unstructured":"Teles F, et al. Viruses, periodontitis, and comorbidities. Periodontol 2000. 2022;89(1):190\u2013206. https:\/\/doi.org\/10.1111\/prd.12435.","journal-title":"Periodontol 2000"},{"issue":"1","key":"6925_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12967-022-03487-4","volume":"20","author":"H Lin","year":"2022","unstructured":"Lin H, et al. Advances of exosomes in periodontitis treatment. J Translational Med. 2022;20(1):279. https:\/\/doi.org\/10.1186\/s12967-022-03487-4.","journal-title":"J Translational Med"},{"key":"6925_CR6","doi-asserted-by":"publisher","unstructured":"Yang B, et al. Immunomodulation in the treatment of periodontitis: progress and perspectives. Front Immunol. 2021;12(781378). https:\/\/doi.org\/10.3389\/fimmu.2021.781378.","DOI":"10.3389\/fimmu.2021.781378"},{"issue":"1","key":"6925_CR7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1186\/s12903-022-02530-6","volume":"22","author":"MM Haque","year":"2022","unstructured":"Haque MM, et al. Advances in novel therapeutic approaches for periodontal diseases. BMC Oral Health. 2022;22(1):492. https:\/\/doi.org\/10.1186\/s12903-022-02530-6.","journal-title":"BMC Oral Health"},{"issue":"15","key":"6925_CR8","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1158\/1078-0432.Ccr-22-3563","volume":"29","author":"Y Dai","year":"2023","unstructured":"Dai Y, et al. Integrative Single-Cell and bulk transcriptomes analyses identify intrinsic HNSCC subtypes with distinct prognoses and therapeutic vulnerabilities. Clin Cancer Research: Official J Am Association Cancer Res. 2023;29(15):2845\u201358. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-22-3563.","journal-title":"Clin Cancer Research: Official J Am Association Cancer Res"},{"issue":"9","key":"6925_CR9","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/s41592-024-02325-3","volume":"21","author":"Y You","year":"2024","unstructured":"You Y, et al. Systematic comparison of sequencing-based Spatial transcriptomic methods. Nat Methods. 2024;21(9):1743\u201354. https:\/\/doi.org\/10.1038\/s41592-024-02325-3.","journal-title":"Nat Methods"},{"key":"6925_CR10","doi-asserted-by":"crossref","unstructured":"Caetano AJ et al. Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10. eLife: 2023, 1210.7554\/eLife.81525","DOI":"10.7554\/eLife.81525.sa2"},{"issue":"6294","key":"6925_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1126\/science.aaf2403","volume":"353","author":"PL St\u00e5hl","year":"2016","unstructured":"St\u00e5hl PL, et al. Visualization and analysis of gene expression in tissue sections by Spatial transcriptomics. Sci (New York NY). 2016;353(6294):78\u201382. https:\/\/doi.org\/10.1126\/science.aaf2403.","journal-title":"Sci (New York NY)"},{"issue":"7871","key":"6925_CR12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","volume":"596","author":"A Rao","year":"2021","unstructured":"Rao A, et al. Exploring tissue architecture using Spatial transcriptomics. Nature. 2021;596(7871):211\u201320. https:\/\/doi.org\/10.1038\/s41586-021-03634-9.","journal-title":"Nature"},{"issue":"1","key":"6925_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","volume":"10","author":"F Guan","year":"2025","unstructured":"Guan F, et al. Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets. Signal Transduct Target Therapy. 2025;10(1):93. https:\/\/doi.org\/10.1038\/s41392-025-02124-y.","journal-title":"Signal Transduct Target Therapy"},{"issue":"12","key":"6925_CR14","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.it.2023.10.004","volume":"44","author":"P Rodr\u00edguez-Morales","year":"2023","unstructured":"Rodr\u00edguez-Morales P, Franklin RA. Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis. Trends Immunol. 2023;44(12):986\u201398. https:\/\/doi.org\/10.1016\/j.it.2023.10.004.","journal-title":"Trends Immunol"},{"issue":"1","key":"6925_CR15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","volume":"8","author":"S Chen","year":"2023","unstructured":"Chen S, et al. Macrophages in immunoregulation and therapeutics. Signal Transduct Target Therapy. 2023;8(1):207. https:\/\/doi.org\/10.1038\/s41392-023-01452-1.","journal-title":"Signal Transduct Target Therapy"},{"issue":"9","key":"6925_CR16","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1111\/jcpe.13841","volume":"50","author":"K Zhang","year":"2023","unstructured":"Zhang K, et al. Inhibition of gingival fibroblast necroptosis mediated by RIPK3\/MLKL attenuates periodontitis. J Clin Periodontol. 2023;50(9):1264\u201379. https:\/\/doi.org\/10.1111\/jcpe.13841.","journal-title":"J Clin Periodontol"},{"issue":"3","key":"6925_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/omi.12442","volume":"39","author":"Z Chen","year":"2024","unstructured":"Chen Z, et al. Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing. Mol Oral Microbiol. 2024;39(3):113\u201324. https:\/\/doi.org\/10.1111\/omi.12442.","journal-title":"Mol Oral Microbiol"},{"issue":"6","key":"6925_CR18","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1007\/s10753-024-02014-5","volume":"47","author":"S Guo","year":"2024","unstructured":"Guo S, et al. ROS-Induced gingival fibroblast senescence: implications in exacerbating inflammatory responses in periodontal disease. Inflammation. 2024;47(6):1918\u201335. https:\/\/doi.org\/10.1007\/s10753-024-02014-5.","journal-title":"Inflammation"},{"key":"6925_CR19","doi-asserted-by":"publisher","unstructured":"Hao Y et al. Integrated analysis of multimodal single-cell data. Cell: 2021, 184(13):3573\u20133587.e3529. https:\/\/doi.org\/10.1016\/j.cell.2021.04.048","DOI":"10.1016\/j.cell.2021.04.048"},{"issue":"1","key":"6925_CR20","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","volume":"20","author":"C Hafemeister","year":"2019","unstructured":"Hafemeister C, Satija R. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 2019;20(1):296. https:\/\/doi.org\/10.1186\/s13059-019-1874-1.","journal-title":"Genome Biol"},{"issue":"12","key":"6925_CR21","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, et al. Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods. 2019;16(12):1289\u201396. https:\/\/doi.org\/10.1038\/s41592-019-0619-0.","journal-title":"Nat Methods"},{"issue":"2","key":"6925_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20(2):163\u201372. https:\/\/doi.org\/10.1038\/s41590-018-0276-y.","journal-title":"Nat Immunol"},{"key":"6925_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, et al. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14:7. https:\/\/doi.org\/10.1186\/1471-2105-14-7.","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"6925_CR24","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","volume":"184","author":"Y Sun","year":"2021","unstructured":"Sun Y, et al. Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell. 2021;184(2):404\u2013e421416. https:\/\/doi.org\/10.1016\/j.cell.2020.11.041.","journal-title":"Cell"},{"issue":"3","key":"6925_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41587-019-0392-8","volume":"38","author":"R Moncada","year":"2020","unstructured":"Moncada R, et al. Integrating microarray-based Spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas. Nat Biotechnol. 2020;38(3):333\u201342. https:\/\/doi.org\/10.1038\/s41587-019-0392-8.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"6925_CR26","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, et al. Inference and analysis of cell-cell communication using cellchat. Nat Commun. 2021;12(1):1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9.","journal-title":"Nat Commun"},{"issue":"2","key":"6925_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys R, et al. NicheNet: modeling intercellular communication by linking ligands to target genes. Nat Methods. 2020;17(2):159\u201362. https:\/\/doi.org\/10.1038\/s41592-019-0667-5.","journal-title":"Nat Methods"},{"issue":"5","key":"6925_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, et al. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"issue":"1","key":"6925_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13059-017-1220-4","volume":"18","author":"RM Quadros","year":"2017","unstructured":"Quadros RM, et al. Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long SsDNA donors and CRISPR ribonucleoproteins. Genome Biol. 2017;18(1):92. https:\/\/doi.org\/10.1186\/s13059-017-1220-4.","journal-title":"Genome Biol"},{"issue":"1","key":"6925_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41368-025-00369-5","volume":"17","author":"Y Yang","year":"2025","unstructured":"Yang Y, et al. Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1\/nuclear factor-\u03baB signaling pathway in dental pulpitis. Int J Oral Sci. 2025;17(1):41. https:\/\/doi.org\/10.1038\/s41368-025-00369-5.","journal-title":"Int J Oral Sci"},{"key":"6925_CR31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bioactmat.2025.03.026","volume":"50","author":"Z Chang","year":"2025","unstructured":"Chang Z, et al. Dynamic-covalent hybrid hydrogels with cartilaginous immune microenvironment temporally regulating meniscus regeneration. Bioactive Mater. 2025;50:14\u201329. https:\/\/doi.org\/10.1016\/j.bioactmat.2025.03.026.","journal-title":"Bioactive Mater"},{"issue":"1","key":"6925_CR32","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1186\/s12967-024-05944-8","volume":"22","author":"Y Huang","year":"2024","unstructured":"Huang Y, et al. Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential. J Translational Med. 2024;22(1):1136. https:\/\/doi.org\/10.1186\/s12967-024-05944-8.","journal-title":"J Translational Med"},{"key":"6925_CR33","doi-asserted-by":"publisher","unstructured":"Qian SJ, et al. Single-Cell RNA sequencing identifies new Inflammation-Promoting cell subsets in Asian patients with chronic periodontitis. Front Immunol. 2021;12(711337). https:\/\/doi.org\/10.3389\/fimmu.2021.711337.","DOI":"10.3389\/fimmu.2021.711337"},{"issue":"1","key":"6925_CR34","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.1038\/s41467-024-49037-y","volume":"15","author":"QT Easter","year":"2024","unstructured":"Easter QT, et al. Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis. Nat Commun. 2024;15(1):5016. https:\/\/doi.org\/10.1038\/s41467-024-49037-y.","journal-title":"Nat Commun"},{"issue":"10","key":"6925_CR35","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1111\/jcpe.13517","volume":"48","author":"P Zhao","year":"2021","unstructured":"Zhao P, et al. Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging. J Clin Periodontol. 2021;48(10):1379\u201392. https:\/\/doi.org\/10.1111\/jcpe.13517.","journal-title":"J Clin Periodontol"},{"key":"6925_CR36","doi-asserted-by":"publisher","first-page":"1493818","DOI":"10.3389\/fcimb.2024.1493818","volume":"14","author":"N L\u00f3pez-Valverde","year":"2024","unstructured":"L\u00f3pez-Valverde N, et al. Inflammation and immune response in the development of periodontal disease: a narrative review. Front Cell Infect Microbiol. 2024;14:1493818. https:\/\/doi.org\/10.3389\/fcimb.2024.1493818.","journal-title":"Front Cell Infect Microbiol"},{"key":"6925_CR37","doi-asserted-by":"publisher","unstructured":"Cai G et al. A Microenvironment-Responsive, controlled release hydrogel delivering Embelin to promote bone repair of periodontitis via Anti-Infection and Osteo-Immune modulation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024, 11(34):e2403786, https:\/\/doi.org\/10.1002\/advs.202403786","DOI":"10.1002\/advs.202403786"},{"key":"6925_CR38","doi-asserted-by":"publisher","unstructured":"Caetano AJ, et al. Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease. eLife. 2021;10(62810). https:\/\/doi.org\/10.7554\/eLife.62810.","DOI":"10.7554\/eLife.62810"},{"issue":"15","key":"6925_CR39","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1016\/j.cell.2021.05.013","volume":"184","author":"DW Williams","year":"2021","unstructured":"Williams DW, et al. Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell. 2021;184(15):4090\u2013e41044015. https:\/\/doi.org\/10.1016\/j.cell.2021.05.013.","journal-title":"Cell"},{"issue":"7","key":"6925_CR40","doi-asserted-by":"publisher","first-page":"151123","DOI":"10.1016\/j.ejcb.2020.151123","volume":"99","author":"SL Alfonso Garc\u00eda","year":"2020","unstructured":"Alfonso Garc\u00eda SL, et al. The phenotype of gingival fibroblasts and their potential use in advanced therapies. Eur J Cell Biol. 2020;99(7):151123. https:\/\/doi.org\/10.1016\/j.ejcb.2020.151123.","journal-title":"Eur J Cell Biol"},{"issue":"3","key":"6925_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/154405910708600310","volume":"86","author":"A Uehara","year":"2007","unstructured":"Uehara A, Takada H. Functional TLRs and nods in human gingival fibroblasts. J Dent Res. 2007;86(3):249\u201354. https:\/\/doi.org\/10.1177\/154405910708600310.","journal-title":"J Dent Res"},{"issue":"3","key":"6925_CR42","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.7150\/thno.65694","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen Y, et al. Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis. Theranostics. 2022;12(3):1074\u201396. https:\/\/doi.org\/10.7150\/thno.65694.","journal-title":"Theranostics"},{"issue":"12","key":"6925_CR43","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.7150\/ijbs.100823","volume":"20","author":"X Liu","year":"2024","unstructured":"Liu X, et al. Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2\/Rac1\/NF-\u03baB pathway. Int J Biol Sci. 2024;20(12):4941\u201356. https:\/\/doi.org\/10.7150\/ijbs.100823.","journal-title":"Int J Biol Sci"},{"issue":"3 Suppl 1","key":"6925_CR44","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1875-595x.1998.tb00711.x","volume":"48","author":"G Ong","year":"1998","unstructured":"Ong G. Periodontal disease and tooth loss. Int Dent J. 1998;48(3 Suppl 1):233\u20138. https:\/\/doi.org\/10.1111\/j.1875-595x.1998.tb00711.x.","journal-title":"Int Dent J"},{"key":"6925_CR45","doi-asserted-by":"publisher","unstructured":"N\u0119dzi-G\u00f3ra M et al. The immune response in periodontal tissues. Archivum immunologiae et therapiae experimentalis 2017, 65(5):421\u20139, https:\/\/doi.org\/10.1007\/s00005-017-0472-8","DOI":"10.1007\/s00005-017-0472-8"},{"issue":"1","key":"6925_CR46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/jper.19-0050","volume":"91","author":"LT Song","year":"2020","unstructured":"Song LT, et al. The interaction between serum amyloid A and Toll-like receptor 2 pathway regulates inflammatory cytokine secretion in human gingival fibroblasts. J Periodontol. 2020;91(1):129\u201337. https:\/\/doi.org\/10.1002\/jper.19-0050.","journal-title":"J Periodontol"},{"issue":"1","key":"6925_CR47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/0022034518796456","volume":"98","author":"K Hirai","year":"2019","unstructured":"Hirai K, et al. Serum amyloid A contributes to chronic apical periodontitis via TLR2 and TLR4. J Dent Res. 2019;98(1):117\u201325. https:\/\/doi.org\/10.1177\/0022034518796456.","journal-title":"J Dent Res"},{"key":"6925_CR48","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jdsr.2022.10.002","volume":"58","author":"L Yin","year":"2022","unstructured":"Yin L, et al. Macrophages in periodontitis: A dynamic shift between tissue destruction and repair. Japanese Dent Sci Rev. 2022;58:336\u201347. https:\/\/doi.org\/10.1016\/j.jdsr.2022.10.002.","journal-title":"Japanese Dent Sci Rev"},{"issue":"3","key":"6925_CR49","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/cei\/uxac122","volume":"211","author":"OA Gonzalez","year":"2023","unstructured":"Gonzalez OA, et al. Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis. Clin Exp Immunol. 2023;211(3):248\u201368. https:\/\/doi.org\/10.1093\/cei\/uxac122.","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"6925_CR50","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","volume":"54","author":"MB Buechler","year":"2021","unstructured":"Buechler MB, et al. Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer. Immunity. 2021;54(5):903\u201315. https:\/\/doi.org\/10.1016\/j.immuni.2021.04.021.","journal-title":"Immunity"},{"issue":"3","key":"6925_CR51","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/s0174-173x(85)80018-2","volume":"5","author":"A Albini","year":"1985","unstructured":"Albini A, et al. Fibroblast chemotaxis. Collagen Relat Res. 1985;5(3):283\u201396. https:\/\/doi.org\/10.1016\/s0174-173x(85)80018-2.","journal-title":"Collagen Relat Res"},{"issue":"6","key":"6925_CR52","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/jper.19-0296","volume":"91","author":"R Clark","year":"2020","unstructured":"Clark R, et al. Expression of colony-stimulating factor 1 and interleukin-34 in gingival tissue and gingival fibroblasts from periodontitis patients and controls. J Periodontol. 2020;91(6):828\u201335. https:\/\/doi.org\/10.1002\/jper.19-0296.","journal-title":"J Periodontol"},{"issue":"2","key":"6925_CR53","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.bbrc.2003.12.096","volume":"314","author":"K Hagihara","year":"2004","unstructured":"Hagihara K, et al. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with Proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system. Biochem Biophys Res Commun. 2004;314(2):363\u20139. https:\/\/doi.org\/10.1016\/j.bbrc.2003.12.096.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"6925_CR54","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41598-017-00782-9","volume":"7","author":"W Li","year":"2017","unstructured":"Li W, et al. Induction of pro-inflammatory genes by serum amyloid A1 in human Amnion fibroblasts. Sci Rep. 2017;7(1):693. https:\/\/doi.org\/10.1038\/s41598-017-00782-9.","journal-title":"Sci Rep"},{"issue":"1","key":"6925_CR55","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jcsm.12491","volume":"11","author":"A Hahn","year":"2020","unstructured":"Hahn A, et al. Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. J Cachexia Sarcopenia Muscle. 2020;11(1):103\u201319. https:\/\/doi.org\/10.1002\/jcsm.12491.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"6925_CR56","doi-asserted-by":"publisher","unstructured":"Zhu P et al. SAA1 promotes ulcerative colitis and activating colonic TLR4\/NF-\u03baB\/NLRP3 signaling pathway. Inflamm 2025DOI: https:\/\/doi.org\/10.1007\/s10753-025-02299-0","DOI":"10.1007\/s10753-025-02299-0"},{"issue":"2","key":"6925_CR57","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/jfb15020032","volume":"15","author":"N Vin\u0163eler","year":"2024","unstructured":"Vin\u0163eler N, et al. Biomaterials functionalized with inflammasome Inhibitors-Premises and perspectives. J Funct Biomaterials. 2024;15(2):32. https:\/\/doi.org\/10.3390\/jfb15020032.","journal-title":"J Funct Biomaterials"},{"issue":"2","key":"6925_CR58","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1365-2249.1995.tb03669.x","volume":"100","author":"C Gabay","year":"1995","unstructured":"Gabay C, et al. IL-1 receptor antagonist (IL-1Ra) does not inhibit the production of C-reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells. Clin Exp Immunol. 1995;100(2):306\u201313. https:\/\/doi.org\/10.1111\/j.1365-2249.1995.tb03669.x.","journal-title":"Clin Exp Immunol"},{"key":"6925_CR59","doi-asserted-by":"publisher","first-page":"1199580","DOI":"10.3389\/fphar.2023.1199580","volume":"14","author":"KN Theken","year":"2023","unstructured":"Theken KN, et al. A randomized, double-blind pilot study of analgesic and anti-inflammatory effects of Naproxen sodium and acetaminophen following dental implant placement surgery. Front Pharmacol. 2023;14:1199580. https:\/\/doi.org\/10.3389\/fphar.2023.1199580.","journal-title":"Front Pharmacol"},{"key":"6925_CR60","doi-asserted-by":"publisher","unstructured":"Loose LD et al. Reduction of acute-phase proteins with tenidap sodium, a cytokine-modulating anti-rheumatic drug. Br J Rheumatol 1993 32 Suppl 3:19\u201325, https:\/\/doi.org\/10.1093\/rheumatology\/32.suppl_3.19","DOI":"10.1093\/rheumatology\/32.suppl_3.19"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06925-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06925-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06925-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:56:59Z","timestamp":1754560619000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06925-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6925"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06925-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"882"}}