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EBV microRNAs, especially rightward transcript (BART) microRNAs, play key roles in the tumor growth of EBVaGC. However, the effects of EBV-miR-BART19-3p in EBVaGC remain largely unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>EBV-miR-BART19-3p was detected by qRT-PCR in EBER in situ hybridization positive gastric carcinoma tissues. CCK8, Colony formation, EdU and Flow cytometry were conducted in gastric cancer cells with overexpression and knockdown of EBV-miR-BART19-3p compared to the negative control, respectively. Tumor xenografts were conducted in vivo. GADD45B was screened by RNA sequencing and dual-luciferase reporter assays implemented with transfecting EBV-miR-BART19-3p antagomir. Proteins were confirmed by Western blotting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>EBV-miR-BART19-3p was highly expressed in EBVaGC and promoted the proliferation of EBV-associated gastric cancer cells in vitro and accelerated xenograft tumor growth in vivo. Knockdown of EBV-miR-BART19-3p induced cell cycle G2\/M phase arrest in AGS EBV cells. Molecularly, EBV-miR-BART19-3p directly targets the 3\u2032-UTR of growth arrest and DNA damage-inducing protein Beta (GADD45B) mRNA and downregulates its protein expression, which consequently reduced cell cycle G2\/M phase arrest. Reconstitution of GADD45B can rescue the proliferation phenotype caused by EBV-miR-BART19-3p in EBVaGC cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our study indicated Epstein-Barr Virus MicroRNA BART19-3p played an oncogenic role by a novel mechanism of inhibiting GADD45B in EBVaGC, which provides new insights and might be a potential therapeutic strategy for EBVaGC patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12967-025-06955-9","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T08:56:45Z","timestamp":1756112205000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epstein-Barr virus-coded miR-BART19-3p promotes proliferation of EBV-associated gastric cancer by inhibiting GADD45B"],"prefix":"10.1186","volume":"23","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YueRu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2587-4379","authenticated-orcid":false,"given":"Runliang","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"6955_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 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