{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:05:59Z","timestamp":1793581559915,"version":"4.5.0"},"reference-count":286,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160565"],"award-info":[{"award-number":["82160565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260565"],"award-info":[{"award-number":["82260565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012259","name":"Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BCJ23035"],"award-info":[{"award-number":["20232BCJ23035"]}],"id":[{"id":"10.13039\/501100012259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2203532"],"award-info":[{"award-number":["GJJ2203532"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Project of Jiangxi Provincial Administration of Traditional Chinese Medicine","award":["2023B1281"],"award-info":[{"award-number":["2023B1281"]}]},{"name":"Open Research Fund of Jiangxi Cancer Hospital & Institute","award":["2021J16"],"award-info":[{"award-number":["2021J16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07005-0","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:34:24Z","timestamp":1756218864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential"],"prefix":"10.1186","volume":"23","author":[{"given":"Liyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeka","family":"Dejenie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Zeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingsheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-an","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"7005_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.579420","volume":"11","author":"G Notas","year":"2020","unstructured":"Notas G, Kampa M, Castanas E. G protein-coupled estrogen receptor in immune cells and its role in immune-related diseases. Front Endocrinol (Lausanne). 2020;11: 579420. https:\/\/doi.org\/10.3389\/fendo.2020.579420.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186490","author":"SC Chuang","year":"2020","unstructured":"Chuang SC, Chen CH, Chou YS, et al. G protein-coupled estrogen receptor mediates cell proliferation through the camp\/pka\/creb pathway in murine bone marrow mesenchymal stem cells. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21186490.","journal-title":"Int J Mol Sci"},{"key":"7005_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00531","volume":"10","author":"C Bian","year":"2019","unstructured":"Bian C, Bai B, Gao Q, et al. 17\u03b2-estradiol regulates glucose metabolism and insulin secretion in rat islet \u03b2 cells through Gper and akt\/mtor\/glut2 pathway. Front Endocrinol (Lausanne). 2019;10: 531. https:\/\/doi.org\/10.3389\/fendo.2019.00531.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100080","author":"G Sharma","year":"2021","unstructured":"Sharma G, Prossnitz ER. Targeting the G protein-coupled Estrogen receptor (gper) in obesity and diabetes. Endocr Metab Sci. 2021. https:\/\/doi.org\/10.1016\/j.endmts.2021.100080.","journal-title":"Endocr Metab Sci"},{"key":"7005_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/978-1-0716-1920-9_21","volume":"2418","author":"G Sharma","year":"2022","unstructured":"Sharma G, Prossnitz ER. Assessment of metabolic regulation by estrogen receptors. Methods Mol Biol. 2022;2418:383\u2013404. https:\/\/doi.org\/10.1007\/978-1-0716-1920-9_21.","journal-title":"Methods Mol Biol"},{"issue":"12","key":"7005_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70131","volume":"14","author":"C He","year":"2024","unstructured":"He C, Peng M, Zeng X, et al. Microenvironmental G protein-coupled estrogen receptor-mediated glutamine metabolic coupling between cancer-associated fibroblasts and triple-negative breast cancer cells governs tumour progression. Clin Transl Med. 2024;14(12): e70131. https:\/\/doi.org\/10.1002\/ctm2.70131.","journal-title":"Clin Transl Med"},{"issue":"3","key":"7005_CR7","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/cells10030672","volume":"10","author":"RA Pepermans","year":"2021","unstructured":"Pepermans RA, Sharma G, Prossnitz ER. G protein-coupled estrogen receptor in cancer and stromal cells: functions and novel therapeutic perspectives. Cells. 2021;10(3):672. https:\/\/doi.org\/10.3390\/cells10030672.","journal-title":"Cells"},{"issue":"2","key":"7005_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70129","volume":"39","author":"M Qi","year":"2025","unstructured":"Qi M, Jin Y, Si L, et al. Estrogen promotes the proliferation and migration of endometrial cancer through the GPER-mediated Notch pathway. J Biochem Mol Toxicol. 2025;39(2): e70129. https:\/\/doi.org\/10.1002\/jbt.70129.","journal-title":"J Biochem Mol Toxicol"},{"issue":"6","key":"7005_CR9","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nchembio.168","volume":"5","author":"MK Dennis","year":"2009","unstructured":"Dennis MK, Burai R, Ramesh C, et al. In vivo effects of a gpr30 antagonist. Nat Chem Biol. 2009;5(6):421\u20137. https:\/\/doi.org\/10.1038\/nchembio.168.","journal-title":"Nat Chem Biol"},{"issue":"7","key":"7005_CR10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41574-023-00822-7","volume":"19","author":"ER Prossnitz","year":"2023","unstructured":"Prossnitz ER, Barton M. The g protein-coupled oestrogen receptor Gper in health and disease: an update. Nat Rev Endocrinol. 2023;19(7):407\u201324. https:\/\/doi.org\/10.1038\/s41574-023-00822-7.","journal-title":"Nat Rev Endocrinol"},{"key":"7005_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076834","author":"L Clusan","year":"2023","unstructured":"Clusan L, Ferri\u00e8re F, Flouriot G, et al. A basic review on estrogen receptor signaling pathways in breast cancer. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24076834.","journal-title":"Int J Mol Sci"},{"issue":"Suppl 2","key":"7005_CR12","doi-asserted-by":"publisher","first-page":"S374","DOI":"10.1111\/bph.16182","volume":"180","author":"SPH Alexander","year":"2023","unstructured":"Alexander SPH, Fabbro D, Kelly E, et al. The concise guide to Pharmacology 2023\/24: transporters. Br J Pharmacol. 2023;180(Suppl 2):S374\u2013s. https:\/\/doi.org\/10.1111\/bph.16182.","journal-title":"Br J Pharmacol"},{"issue":"21","key":"7005_CR13","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1111\/bph.14023","volume":"175","author":"YI Jong","year":"2018","unstructured":"Jong YI, Harmon SK, O\u2019Malley KL. Gpcr signalling from within the cell. Br J Pharmacol. 2018;175(21):4026\u201335. https:\/\/doi.org\/10.1111\/bph.14023.","journal-title":"Br J Pharmacol"},{"issue":"7","key":"7005_CR14","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1080\/07391102.2020.1844059","volume":"40","author":"SU Khan","year":"2022","unstructured":"Khan SU, Ahemad N, Chuah LH, et al. G protein-coupled estrogen receptor-1: homology modeling approaches and application in screening new gper-1 modulators. J Biomol Struct Dyn. 2022;40(7):3325\u201335. https:\/\/doi.org\/10.1080\/07391102.2020.1844059.","journal-title":"J Biomol Struct Dyn"},{"key":"7005_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00517","volume":"11","author":"F Grande","year":"2020","unstructured":"Grande F, Occhiuzzi MA, Lappano R, et al. Computational approaches for the discovery of Gper targeting compounds. Front Endocrinol (Lausanne). 2020;11: 517. https:\/\/doi.org\/10.3389\/fendo.2020.00517.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00725","volume":"10","author":"S Xu","year":"2019","unstructured":"Xu S, Yu S, Dong D, et al. G protein-coupled estrogen receptor: a potential therapeutic target in cancer. Front Endocrinol (Lausanne). 2019;10: 725. https:\/\/doi.org\/10.3389\/fendo.2019.00725.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jsbmb.2019.03.006","volume":"189","author":"M Bello","year":"2019","unstructured":"Bello M, M\u00e9ndez-Luna D, Sarmiento V, et al. Structural and energetic basis for novel epicatechin derivatives acting as Gper agonists through the Mmgbsa method. J Steroid Biochem Mol Biol. 2019;189:176\u201386. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.03.006.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"31","key":"7005_CR18","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1039\/d0ay01052a","volume":"12","author":"L Yong","year":"2020","unstructured":"Yong L, Huang M, Wei Y, et al. Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled Estrogen receptor: spectroscopic analyses and computational simulations. Anal Methods. 2020;12(31):3944\u201353. https:\/\/doi.org\/10.1039\/d0ay01052a.","journal-title":"Anal Methods"},{"key":"7005_CR19","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.16.553551","author":"C Mancinelli","year":"2024","unstructured":"Mancinelli C, Marx DC, Gonzalez-Hernandez AJ, et al. Control of g protein-coupled receptor function via membrane-interacting intrinsically disordered c-terminal domains. BioRxiv. 2024. https:\/\/doi.org\/10.1101\/2023.08.16.553551.","journal-title":"BioRxiv"},{"issue":"1","key":"7005_CR20","doi-asserted-by":"publisher","first-page":"5633","DOI":"10.1038\/s41598-024-54213-7","volume":"14","author":"A Muhammad","year":"2024","unstructured":"Muhammad A, Hixon JC, Pharmacy Yusuf A, et al. Sex-specific epigenetics drive low Gper expression in Gastrointestinal smooth muscles in type 2 diabetic mice. Sci Rep. 2024;14(1):5633. https:\/\/doi.org\/10.1038\/s41598-024-54213-7.","journal-title":"Sci Rep"},{"key":"7005_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1226458","volume":"14","author":"X Li","year":"2023","unstructured":"Li X, Kuang W, Qiu Z, et al. G protein-coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension. Front Endocrinol (Lausanne). 2023;14: 1226458. https:\/\/doi.org\/10.3389\/fendo.2023.1226458.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03438-4","author":"MAG Sirizi","year":"2024","unstructured":"Sirizi MAG, Esmailidehaj M, Mohamadi-Zarch SM, et al. Cardioprotective effects of Gper agonist in ovariectomized diabetic rats: reversing Er stress and structural changes. Naunyn Schmiedebergs Arch Pharmacol. 2024. https:\/\/doi.org\/10.1007\/s00210-024-03438-4.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"7005_CR23","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1080\/07391102.2020.1830853","volume":"40","author":"SU Khan","year":"2022","unstructured":"Khan SU, Ahemad N, Chuah LH, et al. Natural bioactive compounds as a new source of promising g protein-coupled Estrogen receptor (gper) modulators: comprehensive in silico approach. J Biomol Struct Dyn. 2022;40(4):1617\u201328. https:\/\/doi.org\/10.1080\/07391102.2020.1830853.","journal-title":"J Biomol Struct Dyn"},{"key":"7005_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2025.106701","volume":"249","author":"Z Wang","year":"2025","unstructured":"Wang Z, Li X, Liu X, et al. Mechanistic insights into the anti-fibrotic effects of Estrogen via the pi3k-akt pathway in frozen shoulder. J Steroid Biochem Mol Biol. 2025;249: 106701. https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106701.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"7005_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2025.106693","volume":"248","author":"Z Fu","year":"2025","unstructured":"Fu Z, Xin X, Zhan Y, et al. Gper agonist g-1 activates Yap to induce apoptosis in breast cancer cells. J Steroid Biochem Mol Biol. 2025;248: 106693. https:\/\/doi.org\/10.1016\/j.jsbmb.2025.106693.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"7005_CR26","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.Crc-24-0632","author":"CA Natale","year":"2025","unstructured":"Natale CA, Mercado S, Zhuang R, et al. Lns8801: an enantiomerically pure agonist of the g protein-coupled estrogen receptor suitable for clinical development. Cancer Res Commun. 2025. https:\/\/doi.org\/10.1158\/2767-9764.Crc-24-0632.","journal-title":"Cancer Res Commun"},{"issue":"2","key":"7005_CR27","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1210\/en.2004-1064","volume":"146","author":"P Thomas","year":"2005","unstructured":"Thomas P, Pang Y, Filardo EJ, et al. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 2005;146(2):624\u201332. https:\/\/doi.org\/10.1210\/en.2004-1064.","journal-title":"Endocrinology"},{"key":"7005_CR28","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20220953","author":"M Folkmanaite","year":"2023","unstructured":"Folkmanaite M, Zaccolo M. Regulation of cardiac function by camp nanodomains. Biosci Rep. 2023. https:\/\/doi.org\/10.1042\/bsr20220953.","journal-title":"Biosci Rep"},{"key":"7005_CR29","doi-asserted-by":"publisher","first-page":"592628","DOI":"10.3389\/fcell.2020.592628","volume":"8","author":"D Lachowski","year":"2020","unstructured":"Lachowski D, Cortes E, Matellan C, et al. G protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization. Front Cell Dev Biol. 2020;8:592628. https:\/\/doi.org\/10.3389\/fcell.2020.592628.","journal-title":"Front Cell Dev Biol"},{"key":"7005_CR30","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000863","author":"A Loza-Valdes","year":"2021","unstructured":"Loza-Valdes A, Mayer AE, Kassouf T, et al. A phosphoproteomic approach reveals that pkd3 controls pka-mediated glucose and tyrosine metabolism. Life Sci Alliance. 2021. https:\/\/doi.org\/10.26508\/lsa.202000863.","journal-title":"Life Sci Alliance"},{"key":"7005_CR31","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5956","author":"G Sharma","year":"2020","unstructured":"Sharma G, Hu C, Staquicini DI, et al. Preclinical efficacy of the gper-selective agonist G-1 in mouse models of obesity and diabetes. Sci Transl Med. 2020. https:\/\/doi.org\/10.1126\/scitranslmed.aau5956.","journal-title":"Sci Transl Med"},{"key":"7005_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110607","volume":"499","author":"MH Schernthaner-Reiter","year":"2020","unstructured":"Schernthaner-Reiter MH, Trivellin G, Stratakis CA. Chaperones, somatotroph tumors and the cyclic Amp (camp)-dependent protein kinase (pka) pathway. Mol Cell Endocrinol. 2020;499: 110607. https:\/\/doi.org\/10.1016\/j.mce.2019.110607.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2022.103780","volume":"123","author":"GM da Silva","year":"2022","unstructured":"da Silva GM, de Figueiredo CS, da Rocha Oliveira AC, et al. Interleukin-4 activates divergent cell-intrinsic signals to regulate retinal cell proliferation induced by classical growth factors. Mol Cell Neurosci. 2022;123: 103780. https:\/\/doi.org\/10.1016\/j.mcn.2022.103780.","journal-title":"Mol Cell Neurosci"},{"key":"7005_CR34","doi-asserted-by":"publisher","DOI":"10.1101\/2024.11.26.625421","author":"CA Natale","year":"2024","unstructured":"Natale CA, Mercado S, Zhuang R, et al. Lns8801: an enantiomerically pure agonist of the g protein-coupled Estrogen receptor suitable for clinical development. BioRxiv. 2024. https:\/\/doi.org\/10.1101\/2024.11.26.625421.","journal-title":"BioRxiv"},{"key":"7005_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138827","volume":"290","author":"H Zhang","year":"2025","unstructured":"Zhang H, Li C, Lu S, et al. The Gper is an important factor through which somatic cells regulate oocyte maternal mRNA translation and developmental competence. Int J Biol Macromol. 2025;290: 138827. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.138827.","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"7005_CR36","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1007\/s00210-024-03438-4","volume":"398","author":"MAG Sirizi","year":"2025","unstructured":"Sirizi MAG, Esmailidehaj M, Mohamadi-Zarch SM, et al. Cardioprotective effects of Gper agonist in ovariectomized diabetic rats: reversing Er stress and structural changes. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(3):2855\u201365. https:\/\/doi.org\/10.1007\/s00210-024-03438-4.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"7005_CR37","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.theriogenology.2023.07.031","volume":"210","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhang J, Sun J, et al. Hypoxia enhances steroidogenic competence of Buffalo (bubalus bubalis) granulosa cells. Theriogenology. 2023;210:214\u201320. https:\/\/doi.org\/10.1016\/j.theriogenology.2023.07.031.","journal-title":"Theriogenology"},{"issue":"2","key":"7005_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188619","volume":"1876","author":"S Mandal","year":"2021","unstructured":"Mandal S, Bandyopadhyay S, Tyagi K, et al. Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase c gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis. Biochimica et Biophysica Acta (BBA). 2021;1876(2): 188619. https:\/\/doi.org\/10.1016\/j.bbcan.2021.188619.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"10","key":"7005_CR39","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1002\/glia.23679","volume":"67","author":"A Pinto-Duarte","year":"2019","unstructured":"Pinto-Duarte A, Roberts AJ, Ouyang K, et al. Impairments in remote memory caused by the lack of type 2 IP(3) receptors. Glia. 2019;67(10):1976\u201389. https:\/\/doi.org\/10.1002\/glia.23679.","journal-title":"Glia"},{"key":"7005_CR40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041544","author":"LV Pinheiro","year":"2024","unstructured":"Pinheiro LV, Costa-Pinheiro P, Wellen KE. Metabolic signaling in cancer. Cold Spring Harb Perspect Med. 2024. https:\/\/doi.org\/10.1101\/cshperspect.a041544.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"7005_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162488","author":"PS Tappia","year":"2022","unstructured":"Tappia PS, Dhalla NS. Upregulation of phospholipase c gene expression due to norepinephrine-induced hypertrophic response. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11162488.","journal-title":"Cells"},{"key":"7005_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev-pharmtox-031122-121944","volume":"63","author":"JB Arterburn","year":"2023","unstructured":"Arterburn JB, Prossnitz ER. G protein-coupled estrogen receptor gper: molecular pharmacology and therapeutic applications. Annu Rev Pharmacol Toxicol. 2023;63:295\u2013320. https:\/\/doi.org\/10.1146\/annurev-pharmtox-031122-121944.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"729","key":"7005_CR43","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abo0264","volume":"15","author":"M Cooke","year":"2022","unstructured":"Cooke M, Kazanietz MG. Overarching roles of Diacylglycerol signaling in cancer development and antitumor immunity. Sci Signal. 2022;15(729): eabo0264. https:\/\/doi.org\/10.1126\/scisignal.abo0264.","journal-title":"Sci Signal"},{"key":"7005_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiae534","author":"AM Laxalt","year":"2025","unstructured":"Laxalt AM, van Hooren M, Munnik T. Plant pi-plc signaling in stress and development. Plant Physiol. 2025. https:\/\/doi.org\/10.1093\/plphys\/kiae534.","journal-title":"Plant Physiol"},{"issue":"1","key":"7005_CR45","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12944-020-01286-8","volume":"19","author":"K Kolczynska","year":"2020","unstructured":"Kolczynska K, Loza-Valdes A, Hawro I, et al. Diacylglycerol-evoked activation of Pkc and Pkd isoforms in regulation of glucose and lipid metabolism: a review. Lipids Health Dis. 2020;19(1):113. https:\/\/doi.org\/10.1186\/s12944-020-01286-8.","journal-title":"Lipids Health Dis"},{"issue":"10","key":"7005_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114831","volume":"43","author":"AE Becker","year":"2024","unstructured":"Becker AE, Kochanowski P, Wu PK, et al. Erk1\/2 interaction with Dhps regulates eif5a deoxyhypusination independently of Erk kinase activity. Cell Rep. 2024;43(10): 114831. https:\/\/doi.org\/10.1016\/j.celrep.2024.114831.","journal-title":"Cell Rep"},{"issue":"10","key":"7005_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107817","volume":"26","author":"AE Postiglione","year":"2023","unstructured":"Postiglione AE, Adams LL, Ekhator ES, et al. Hydrogen peroxide-dependent oxidation of erk2 within its d-recruitment site alters its substrate selection. iScience. 2023;26(10): 107817. https:\/\/doi.org\/10.1016\/j.isci.2023.107817.","journal-title":"iScience"},{"issue":"7","key":"7005_CR48","doi-asserted-by":"publisher","first-page":"824","DOI":"10.2174\/1574888x16666210712100002","volume":"16","author":"ND Zeybek","year":"2021","unstructured":"Zeybek ND, Baysal E, Bozdemir O, et al. Hippo signaling: a stress response pathway in stem cells. Curr Stem Cell Res Ther. 2021;16(7):824\u201339. https:\/\/doi.org\/10.2174\/1574888x16666210712100002.","journal-title":"Curr Stem Cell Res Ther"},{"issue":"3","key":"7005_CR49","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2174\/2211536610666210716153929","volume":"10","author":"Y Xu","year":"2021","unstructured":"Xu Y, Huang X, Luo Q, et al. Micrornas involved in oxidative stress processes regulating physiological and pathological responses. Microrna. 2021;10(3):164\u201380. https:\/\/doi.org\/10.2174\/2211536610666210716153929.","journal-title":"Microrna"},{"key":"7005_CR50","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3389\/fendo.2019.00708","volume":"10","author":"P Ranganathan","year":"2019","unstructured":"Ranganathan P, Nadig N, Nambiar S. Non-canonical Estrogen signaling in endocrine resistance. Front Endocrinol (Lausanne). 2019;10:708. https:\/\/doi.org\/10.3389\/fendo.2019.00708.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"7005_CR51","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1089\/dna.2019.4724","volume":"38","author":"W Zhang","year":"2019","unstructured":"Zhang W, Wu X, Pei Z, et al. Gdf5 promotes white adipose tissue thermogenesis via p38 Mapk signaling pathway. DNA Cell Biol. 2019;38(11):1303\u201312. https:\/\/doi.org\/10.1089\/dna.2019.4724.","journal-title":"DNA Cell Biol"},{"key":"7005_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115433","volume":"167","author":"SW Nam","year":"2023","unstructured":"Nam SW, Hwang JW, Han YH. A novel Berberine derivative targeting adipocyte differentiation to alleviate tnf-\u03b1-induced inflammatory effects and insulin resistance in op9 cells. Biomed Pharmacother. 2023;167: 115433. https:\/\/doi.org\/10.1016\/j.biopha.2023.115433.","journal-title":"Biomed Pharmacother"},{"issue":"Pt 4","key":"7005_CR53","doi-asserted-by":"publisher","first-page":"135376","DOI":"10.1016\/j.ijbiomac.2024.135376","volume":"279","author":"F Ding","year":"2024","unstructured":"Ding F, Zheng P, Yan XY, et al. Adipocyte-secreted prelp promotes adipocyte differentiation and adipose tissue fibrosis by binding with p75(ntr) to activate fak\/mapk signaling. Int J Biol Macromol. 2024;279(Pt 4):135376. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135376.","journal-title":"Int J Biol Macromol"},{"key":"7005_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122001","author":"Z Xu","year":"2016","unstructured":"Xu Z, Sun J, Tong Q, et al. The role of erk1\/2 in the development of diabetic cardiomyopathy. Int J Mol Sci. 2016. https:\/\/doi.org\/10.3390\/ijms17122001.","journal-title":"Int J Mol Sci"},{"key":"7005_CR55","doi-asserted-by":"publisher","unstructured":"Feng J, Lu S, Ou B, et al. The role of Jnk signaling pathway in obesity-driven insulin resistance. Diabetes Metab Syndr Obes. 2020;13:1399\u2013406. https:\/\/doi.org\/10.2147\/dmso.S236127.","DOI":"10.2147\/dmso.S236127"},{"key":"7005_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00055","volume":"10","author":"A Guti\u00e9rrez","year":"2019","unstructured":"Guti\u00e9rrez A, Contreras C, S\u00e1nchez A, et al. Role of phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), and protein kinase c (PKC) in calcium signaling pathways linked to the \u03b1(1)-adrenoceptor in resistance arteries. Front Physiol. 2019;10: 55. https:\/\/doi.org\/10.3389\/fphys.2019.00055.","journal-title":"Front Physiol"},{"key":"7005_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114721","volume":"192","author":"JS Park","year":"2021","unstructured":"Park JS, Lee GH, Jin SW, et al. G protein-coupled Estrogen receptor regulates the klf2-dependent enos expression by activating of ca(2+) and Egfr signaling pathway in human endothelial cells. Biochem Pharmacol. 2021;192: 114721. https:\/\/doi.org\/10.1016\/j.bcp.2021.114721.","journal-title":"Biochem Pharmacol"},{"issue":"12","key":"7005_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293630","volume":"18","author":"H Azizian","year":"2023","unstructured":"Azizian H, Farhadi Z, Bader M, et al. Gper activation attenuates cardiac dysfunction by upregulating the sirt1\/3-ampk-ucp2 pathway in postmenopausal diabetic rats. PLoS One. 2023;18(12): e0293630. https:\/\/doi.org\/10.1371\/journal.pone.0293630.","journal-title":"PLoS One"},{"key":"7005_CR59","doi-asserted-by":"publisher","first-page":"175346662412719","DOI":"10.1177\/17534666241271990","volume":"18","author":"J Hou","year":"2024","unstructured":"Hou J, Nie Y, Wen Y, et al. The role and mechanism of Ampk in pulmonary hypertension. Ther Adv Respir Dis. 2024;18:17534666241271990. https:\/\/doi.org\/10.1177\/17534666241271990.","journal-title":"Ther Adv Respir Dis"},{"issue":"2","key":"7005_CR60","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig S, Shaw RJ, Ampk. Guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121\u201335. https:\/\/doi.org\/10.1038\/nrm.2017.95.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"7005_CR61","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1080\/09553002.2023.2295297","volume":"100","author":"T Shimura","year":"2024","unstructured":"Shimura T, Sunaga K, Yamazaki M, et al. Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response. Int J Radiat Biol. 2024;100(4):584\u201394. https:\/\/doi.org\/10.1080\/09553002.2023.2295297.","journal-title":"Int J Radiat Biol"},{"issue":"10","key":"7005_CR62","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nrm2249","volume":"8","author":"DG Hardie","year":"2007","unstructured":"Hardie DG. Amp-activated\/snf1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007;8(10):774\u201385. https:\/\/doi.org\/10.1038\/nrm2249.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"7005_CR63","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1038\/s12276-023-01072-3","volume":"55","author":"H Sun","year":"2023","unstructured":"Sun H, Kemper JK. Microrna regulation of Ampk in nonalcoholic fatty liver disease. Exp Mol Med. 2023;55(9):1974\u201381. https:\/\/doi.org\/10.1038\/s12276-023-01072-3.","journal-title":"Exp Mol Med"},{"key":"7005_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/ph14010049","author":"D M\u00e9ndez-Luna","year":"2021","unstructured":"M\u00e9ndez-Luna D, Morelos-Garnica LA, Garc\u00eda-V\u00e1zquez JB, et al. Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on Gper as antiproliferative compounds against renal, liver and pancreatic cancer cells. Pharmaceuticals (Basel). 2021. https:\/\/doi.org\/10.3390\/ph14010049.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"7005_CR65","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim J, Kundu M, Viollet B, et al. Ampk and Mtor regulate autophagy through direct phosphorylation of ulk1. Nat Cell Biol. 2011;13(2):132\u201341. https:\/\/doi.org\/10.1038\/ncb2152.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"7005_CR66","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.celrep.2018.12.036","volume":"26","author":"D Garcia","year":"2019","unstructured":"Garcia D, Hellberg K, Chaix A, et al. Genetic liver-specific Ampk activation protects against diet-induced obesity and Nafld. Cell Rep. 2019;26(1):192\u2013208. https:\/\/doi.org\/10.1016\/j.celrep.2018.12.036.","journal-title":"Cell Rep"},{"issue":"5","key":"7005_CR67","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1039\/c8ra09318k","volume":"9","author":"SU Khan","year":"2019","unstructured":"Khan SU, Ahemad N, Chuah LH, et al. Sequential ligand- and structure-based virtual screening approach for the identification of potential g protein-coupled Estrogen receptor-1 (gper-1) modulators. RSC Adv. 2019;9(5):2525\u201338. https:\/\/doi.org\/10.1039\/c8ra09318k.","journal-title":"RSC Adv"},{"key":"7005_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111286","volume":"137","author":"G Lu","year":"2021","unstructured":"Lu G, Wu Z, Shang J, et al. The effects of metformin on autophagy. Biomed Pharmacother. 2021;137: 111286. https:\/\/doi.org\/10.1016\/j.biopha.2021.111286.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"7005_CR69","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41420-023-01654-0","volume":"9","author":"F Cirillo","year":"2023","unstructured":"Cirillo F, Talia M, Santolla MF, et al. Gper deletion triggers inhibitory effects in triple negative breast cancer (tnbc) cells through the jnk\/c-jun\/p53\/noxa transduction pathway. Cell Death Discov. 2023;9(1):353. https:\/\/doi.org\/10.1038\/s41420-023-01654-0.","journal-title":"Cell Death Discov"},{"key":"7005_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020306","author":"LH Hsu","year":"2019","unstructured":"Hsu LH, Chu NM, Lin YF, et al. G-protein coupled estrogen receptor in breast cancer. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20020306.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"7005_CR71","doi-asserted-by":"publisher","first-page":"e29428","DOI":"10.1016\/j.heliyon.2024.e29428","volume":"10","author":"X Wang","year":"2024","unstructured":"Wang X, Zhou J, Wang Y, et al. Effect of astrocyte Gper on the optic nerve inflammatory response following optic nerve injury in mice. Heliyon. 2024;10(8):e29428. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e29428.","journal-title":"Heliyon"},{"issue":"13","key":"7005_CR72","doi-asserted-by":"publisher","first-page":"10601","DOI":"10.1021\/acs.jmedchem.3c02458","volume":"67","author":"BP Awasthi","year":"2024","unstructured":"Awasthi BP, Chaudhary P, Lim D, et al. G protein-coupled estrogen receptor-mediated anti-inflammatory and mucosal healing activity of a trimethylpyridinol analogue in inflammatory bowel disease. J Med Chem. 2024;67(13):10601\u201321. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c02458.","journal-title":"J Med Chem"},{"issue":"5","key":"7005_CR73","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.3892\/ijmm.2018.3470","volume":"41","author":"L Zhang","year":"2018","unstructured":"Zhang L, Zhao Y, Guo L. 17\u03b2-estradiol protects ins-1 Insulinoma cells from mitophagy via g protein-coupled Estrogen receptors and the pi3k\/akt signaling pathway. Int J Mol Med. 2018;41(5):2839\u201346. https:\/\/doi.org\/10.3892\/ijmm.2018.3470.","journal-title":"Int J Mol Med"},{"key":"7005_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111053","volume":"519","author":"LJ Yuan","year":"2021","unstructured":"Yuan LJ, Zhang M, Chen S, et al. Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with Gper in MPTP\/MPP(+)-induced astrocyte activation. Mol Cell Endocrinol. 2021;519: 111053. https:\/\/doi.org\/10.1016\/j.mce.2020.111053.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR75","doi-asserted-by":"publisher","DOI":"10.36922\/gpd.4632","author":"O Dr\u00e4ger","year":"2024","unstructured":"Dr\u00e4ger O, Gottschalk J, Wischmeyer E, et al. G protein-coupled estrogen receptor 1 and its role in sex-specific differences in neurological and cardiovascular diseases. Gene & Protein in Disease. 2024. https:\/\/doi.org\/10.36922\/gpd.4632.","journal-title":"Gene & Protein in Disease"},{"key":"7005_CR76","doi-asserted-by":"publisher","unstructured":"Shao X, Li J, Xu F et al. Mir-155-mediated deregulation of gper1 plays an important role in the gender differences related to inflammatory bowel disease. Can J Infect Dis Med Microbiol, 2020, 2020: 8811477.https:\/\/doi.org\/10.1155\/2020\/8811477","DOI":"10.1155\/2020\/8811477"},{"key":"7005_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.638171","volume":"11","author":"YA Qiu","year":"2021","unstructured":"Qiu YA, Xiong J, Fu Q, et al. Gper-induced Erk signaling decreases cell viability of hepatocellular carcinoma. Front Oncol. 2021;11: 638171. https:\/\/doi.org\/10.3389\/fonc.2021.638171.","journal-title":"Front Oncol"},{"issue":"3","key":"7005_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2024.100924","volume":"24","author":"L He","year":"2024","unstructured":"He L, Wang X, Chen X. Unveiling the role of Micrornas in metabolic dysregulation of gestational diabetes mellitus. Reprod Biol. 2024;24(3): 100924. https:\/\/doi.org\/10.1016\/j.repbio.2024.100924.","journal-title":"Reprod Biol"},{"key":"7005_CR79","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jsbmb.2017.02.012","volume":"176","author":"G Sharma","year":"2018","unstructured":"Sharma G, Mauvais-Jarvis F, Prossnitz ER. Roles of g protein-coupled estrogen receptor Gper in metabolic regulation. J Steroid Biochem Mol Biol. 2018;176:31\u20137. https:\/\/doi.org\/10.1016\/j.jsbmb.2017.02.012.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"7005_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120926","volume":"308","author":"Y Yao","year":"2022","unstructured":"Yao Y, Wang H, Yang Y, et al. Dehydroepiandrosterone activates the gper-mediated Ampk signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets. Life Sci. 2022;308: 120926. https:\/\/doi.org\/10.1016\/j.lfs.2022.120926.","journal-title":"Life Sci"},{"issue":"9","key":"7005_CR81","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1002\/ptr.7526","volume":"36","author":"TH Pham","year":"2022","unstructured":"Pham TH, Lee GH, Jin SW, et al. Puerarin attenuates hepatic steatosis via g-protein-coupled estrogen receptor-mediated calcium and sirt1 signaling pathways. Phytother Res. 2022;36(9):3601\u201318. https:\/\/doi.org\/10.1002\/ptr.7526.","journal-title":"Phytother Res"},{"key":"7005_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120676","volume":"303","author":"Q Li","year":"2022","unstructured":"Li Q, Yang Y, Wang H, et al. Genistein accelerates glucose catabolism via activation the GPER-mediated cAMP\/PKA-AMPK signaling pathway in broiler chickens. Life Sci. 2022;303: 120676. https:\/\/doi.org\/10.1016\/j.lfs.2022.120676.","journal-title":"Life Sci"},{"issue":"1","key":"7005_CR83","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1186\/s12964-024-01760-1","volume":"22","author":"X Liu","year":"2024","unstructured":"Liu X, Ren B, Ren J, et al. The significant role of amino acid metabolic reprogramming in cancer. Cell Commun Signal. 2024;22(1):380. https:\/\/doi.org\/10.1186\/s12964-024-01760-1.","journal-title":"Cell Commun Signal"},{"key":"7005_CR84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-030-74180-8_3","volume":"1332","author":"Y Yang","year":"2021","unstructured":"Yang Y, He Y, Jin Y, et al. Amino acids in endoplasmic reticulum stress and redox signaling. Adv Exp Med Biol. 2021;1332:35\u201349. https:\/\/doi.org\/10.1007\/978-3-030-74180-8_3.","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"7005_CR85","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nrendo.2011.122","volume":"7","author":"ER Prossnitz","year":"2011","unstructured":"Prossnitz ER, Barton M. The g-protein-coupled estrogen receptor Gper in health and disease. Nat Rev Endocrinol. 2011;7(12):715\u201326. https:\/\/doi.org\/10.1038\/nrendo.2011.122.","journal-title":"Nat Rev Endocrinol"},{"issue":"52","key":"7005_CR86","doi-asserted-by":"publisher","first-page":"43234","DOI":"10.1074\/jbc.M112.417303","volume":"287","author":"MF Santolla","year":"2012","unstructured":"Santolla MF, Lappano R, De Marco P, et al. G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17\u03b2-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem. 2012;287(52):43234\u201345. https:\/\/doi.org\/10.1074\/jbc.M112.417303.","journal-title":"J Biol Chem"},{"key":"7005_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061521","author":"P Avena","year":"2022","unstructured":"Avena P, Casaburi I, Zavaglia L, et al. 27-hydroxycholesterol binds Gper and induces progression of estrogen receptor-negative breast cancer. Cancers (Basel). 2022. https:\/\/doi.org\/10.3390\/cancers14061521.","journal-title":"Cancers (Basel)"},{"key":"7005_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417460","author":"M Gaggini","year":"2023","unstructured":"Gaggini M, Vassalle C. Lipids metabolism and cardiometabolic diseases. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242417460.","journal-title":"Int J Mol Sci"},{"key":"7005_CR89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010589","author":"I Florance","year":"2022","unstructured":"Florance I, Ramasubbu S. Current understanding on the role of lipids in macrophages and associated diseases. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms24010589.","journal-title":"Int J Mol Sci"},{"key":"7005_CR90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136878","author":"H Fan","year":"2024","unstructured":"Fan H, Tan Y. Lipid droplet-mitochondria contacts in health and disease. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25136878.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"7005_CR91","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/nutrit\/nuab021","volume":"80","author":"M Tian","year":"2022","unstructured":"Tian M, Wu Z, Heng J, et al. Novel advances in understanding fatty acid-binding g protein-coupled receptors and their roles in controlling energy balance. Nutr Rev. 2022;80(2):187\u201399. https:\/\/doi.org\/10.1093\/nutrit\/nuab021.","journal-title":"Nutr Rev"},{"issue":"8","key":"7005_CR92","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1172\/jci44564","volume":"121","author":"JP Tiano","year":"2011","unstructured":"Tiano JP, Delghingaro-Augusto V, Le May C, et al. Estrogen receptor activation reduces lipid synthesis in pancreatic Islets and prevents \u03b2 cell failure in rodent models of type 2 diabetes. J Clin Invest. 2011;121(8):3331\u201342. https:\/\/doi.org\/10.1172\/jci44564.","journal-title":"J Clin Invest"},{"issue":"7","key":"7005_CR93","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1210\/en.2011-1980","volume":"153","author":"JP Tiano","year":"2012","unstructured":"Tiano JP, Mauvais-Jarvis F. Molecular mechanisms of estrogen receptors\u2019 suppression of lipogenesis in pancreatic \u03b2-cells. Endocrinology. 2012;153(7):2997\u20133005. https:\/\/doi.org\/10.1210\/en.2011-1980.","journal-title":"Endocrinology"},{"key":"7005_CR94","doi-asserted-by":"publisher","unstructured":"Liu D, Zheng M, Lu C et al. Gpr30 selective agonist g1 exhibits antiobesity effects and promotes insulin resistance and gluconeogenesis in postmenopausal mice fed a high-fat diet. J Lipids, 2024, 2024: 5513473.https:\/\/doi.org\/10.1155\/2024\/5513473","DOI":"10.1155\/2024\/5513473"},{"issue":"4","key":"7005_CR95","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s00709-020-01488-y","volume":"257","author":"M Kotula-Balak","year":"2020","unstructured":"Kotula-Balak M, Gorowska-Wojtowicz E, Milon A, et al. Towards understanding Leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator-activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors? Protoplasma. 2020;257(4):1149\u201363. https:\/\/doi.org\/10.1007\/s00709-020-01488-y.","journal-title":"Protoplasma"},{"issue":"3","key":"7005_CR96","doi-asserted-by":"publisher","DOI":"10.5812\/ijem-123560","volume":"20","author":"F Jafarynezhad","year":"2022","unstructured":"Jafarynezhad F, Shahbazian M, Farhadi Z, et al. The G-protein-coupled estrogen receptor agonist prevents cardiac lipid accumulation by stimulating cardiac peroxisome proliferator-activated receptor \u03b1: a preclinical study in ovariectomized-diabetic rat model. Int J Endocrinol Metab. 2022;20(3): e123560. https:\/\/doi.org\/10.5812\/ijem-123560.","journal-title":"Int J Endocrinol Metab"},{"issue":"1","key":"7005_CR97","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/jb\/mvac033","volume":"172","author":"Y Matsumura","year":"2022","unstructured":"Matsumura Y, Osborne TF, Sakai J. Epigenetic and environmental regulation of adipocyte function. J Biochem. 2022;172(1):9\u201316. https:\/\/doi.org\/10.1093\/jb\/mvac033.","journal-title":"J Biochem"},{"key":"7005_CR98","doi-asserted-by":"publisher","DOI":"10.3390\/nu16010038","author":"K Arisawa","year":"2023","unstructured":"Arisawa K, Matsuoka A, Ozawa N, et al. Gper\/pka-dependent enhancement of hormone-sensitive lipase phosphorylation in 3T3-L1 adipocytes by Piceatannol. Nutrients. 2023. https:\/\/doi.org\/10.3390\/nu16010038.","journal-title":"Nutrients"},{"key":"7005_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.112142","volume":"583","author":"MI Valle","year":"2024","unstructured":"Valle MI, Cutini PH, Cepeda SB, et al. Direct in vitro action of estrone on uterine and white adipose tissue in obesity. Mol Cell Endocrinol. 2024;583: 112142. https:\/\/doi.org\/10.1016\/j.mce.2023.112142.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2023.109689","volume":"744","author":"S Zhu","year":"2023","unstructured":"Zhu S, Wang S, Luo T. Exogenous galanin alleviates hepatic steatosis by promoting autophagy via the ampk-mtor pathway. Arch Biochem Biophys. 2023;744: 109689. https:\/\/doi.org\/10.1016\/j.abb.2023.109689.","journal-title":"Arch Biochem Biophys"},{"key":"7005_CR101","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126499","author":"D Hanafi","year":"2024","unstructured":"Hanafi D, Onyenwoke RU, Kimbro KS. The G-protein-coupled estrogen receptor selective agonist G-1 attenuates cell viability and migration in high-grade serous ovarian cancer cell lines. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25126499.","journal-title":"Int J Mol Sci"},{"key":"7005_CR102","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-3-319-70178-3_12","volume":"1043","author":"BT Palmisano","year":"2017","unstructured":"Palmisano BT, Zhu L, Stafford JM. Role of estrogens in the regulation of liver lipid metabolism. Adv Exp Med Biol. 2017;1043:227\u201356. https:\/\/doi.org\/10.1007\/978-3-319-70178-3_12.","journal-title":"Adv Exp Med Biol"},{"key":"7005_CR103","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/978-3-319-70178-3_20","volume":"1043","author":"G Sharma","year":"2017","unstructured":"Sharma G, Prossnitz ER. G-protein-coupled estrogen receptor (gper) and sex-specific metabolic homeostasis. Adv Exp Med Biol. 2017;1043:427\u201353. https:\/\/doi.org\/10.1007\/978-3-319-70178-3_20.","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"7005_CR104","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1053\/j.gastro.2008.12.051","volume":"136","author":"Y Xue","year":"2009","unstructured":"Xue Y, Fleet JC. Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology. 2009;136(4):1317. https:\/\/doi.org\/10.1053\/j.gastro.2008.12.051.","journal-title":"Gastroenterology"},{"key":"7005_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163353","author":"L Huss","year":"2022","unstructured":"Huss L, Butt ST, Borgquist S, et al. Levels of vitamin D and expression of the vitamin D receptor in relation to breast cancer risk and survival. Nutrients. 2022. https:\/\/doi.org\/10.3390\/nu14163353.","journal-title":"Nutrients"},{"key":"7005_CR106","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-017-0053-z","volume":"27","author":"AP Zanatta","year":"2017","unstructured":"Zanatta AP, Brouard V, Gautier C, et al. Interactions between oestrogen and 1\u03b1,25(oh)(2)-vitamin d(3) signalling and their roles in spermatogenesis and spermatozoa functions. Basic Clin Androl. 2017;27: 10. https:\/\/doi.org\/10.1186\/s12610-017-0053-z.","journal-title":"Basic Clin Androl"},{"key":"7005_CR107","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3389\/fnins.2019.01351","volume":"13","author":"X Ding","year":"2019","unstructured":"Ding X, Gao T, Gao P, et al. Activation of the G protein-coupled Estrogen receptor elicits store calcium release and phosphorylation of the mu-opioid receptors in the human neuroblastoma sh-sy5y cells. Front Neurosci. 2019;13:1351. https:\/\/doi.org\/10.3389\/fnins.2019.01351.","journal-title":"Front Neurosci"},{"issue":"1","key":"7005_CR108","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11011-011-9266-6","volume":"27","author":"S Subramanian","year":"2012","unstructured":"Subramanian S, Miller LM, Grafe MR, et al. Contribution of gpr30 for 1,25 dihydroxyvitamin d\u2083 protection in Eae. Metab Brain Dis. 2012;27(1):29\u201335. https:\/\/doi.org\/10.1007\/s11011-011-9266-6.","journal-title":"Metab Brain Dis"},{"key":"7005_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/cells12212571","author":"M Ahmadian Elmi","year":"2023","unstructured":"Ahmadian Elmi M, Motamed N, Picard D. Proteomic analyses of the G protein-coupled estrogen receptor GPER1 reveal constitutive links to endoplasmic reticulum, glycosylation, trafficking, and calcium signaling. Cells. 2023. https:\/\/doi.org\/10.3390\/cells12212571.","journal-title":"Cells"},{"issue":"11","key":"7005_CR110","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1002\/iub.2118","volume":"71","author":"X Lin","year":"2019","unstructured":"Lin X, Li L, Wu S, et al. Activation of GPR30 promotes osteogenic differentiation of MC3T3-E1 cells: an implication in osteoporosis. IUBMB Life. 2019;71(11):1751\u20139. https:\/\/doi.org\/10.1002\/iub.2118.","journal-title":"IUBMB Life"},{"key":"7005_CR111","doi-asserted-by":"publisher","first-page":"153146","DOI":"10.1016\/j.phymed.2019.153146","volume":"68","author":"QC Wu","year":"2020","unstructured":"Wu QC, Tang XY, Dai ZQ, et al. Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-\u03b1 and gpr30 mediated p38 signalling pathway on mc3t3-e1 cells. Phytomedicine. 2020;68:153146. https:\/\/doi.org\/10.1016\/j.phymed.2019.153146.","journal-title":"Phytomedicine"},{"key":"7005_CR112","doi-asserted-by":"publisher","first-page":"155284","DOI":"10.1016\/j.phymed.2023.155284","volume":"124","author":"Z Jiang","year":"2024","unstructured":"Jiang Z, Deng L, Li M, et al. Ginsenoside rg1 modulates pi3k\/akt pathway for enhanced osteogenesis via Gper. Phytomedicine. 2024;124:155284. https:\/\/doi.org\/10.1016\/j.phymed.2023.155284.","journal-title":"Phytomedicine"},{"key":"7005_CR113","doi-asserted-by":"publisher","unstructured":"Radhakrishnan R, Lor A, Li D et al. Methodology for studying interactions of vitamin a membrane receptors and opsin protein with their ligands in generating the retinylidene protein. J Vis Exp, 2024, (212).https:\/\/doi.org\/10.3791\/67036","DOI":"10.3791\/67036"},{"key":"7005_CR114","doi-asserted-by":"publisher","DOI":"10.3389\/fopht.2024.1331298","volume":"4","author":"WL Pi\u00f1on-Teal","year":"2024","unstructured":"Pi\u00f1on-Teal WL, Ogilvie JM. G protein-coupled estrogen receptor expression in postnatal developing mouse retina. Front Ophthalmol. 2024;4: 1331298. https:\/\/doi.org\/10.3389\/fopht.2024.1331298.","journal-title":"Front Ophthalmol"},{"issue":"2","key":"7005_CR115","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/cne.24056","volume":"525","author":"LA Mangiamele","year":"2017","unstructured":"Mangiamele LA, Gomez JR, Curtis NJ, et al. Gper\/gpr30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (carassius auratus) and colocalizes with isotocin. J Comp Neurol. 2017;525(2):252\u201370. https:\/\/doi.org\/10.1002\/cne.24056.","journal-title":"J Comp Neurol"},{"issue":"4","key":"7005_CR116","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.yfrne.2012.10.002","volume":"33","author":"P Micevych","year":"2012","unstructured":"Micevych P. Membrane-initiated estradiol signaling regulates the central nervous system. Front Neuroendocrinol. 2012;33(4):329\u201330. https:\/\/doi.org\/10.1016\/j.yfrne.2012.10.002.","journal-title":"Front Neuroendocrinol"},{"issue":"5","key":"7005_CR117","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1002\/jcp.30149","volume":"236","author":"R Li","year":"2021","unstructured":"Li R, Wang Y, Chen P, et al. G-protein-coupled estrogen receptor protects retinal ganglion cells via inhibiting endoplasmic reticulum stress under hyperoxia. J Cell Physiol. 2021;236(5):3780\u20138. https:\/\/doi.org\/10.1002\/jcp.30149.","journal-title":"J Cell Physiol"},{"issue":"17","key":"7005_CR118","doi-asserted-by":"publisher","first-page":"17367","DOI":"10.18632\/aging.103733","volume":"12","author":"R Li","year":"2020","unstructured":"Li R, Wang Y, Chen P, et al. G-protein coupled Estrogen receptor activation protects the viability of hyperoxia-treated primary murine retinal microglia by reducing Er stress. Aging. 2020;12(17):17367\u201379. https:\/\/doi.org\/10.18632\/aging.103733.","journal-title":"Aging"},{"key":"7005_CR119","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR120000850","volume":"62","author":"EH Choi","year":"2021","unstructured":"Choi EH, Daruwalla A, Suh S, et al. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021;62: 100040. https:\/\/doi.org\/10.1194\/jlr.TR120000850.","journal-title":"J Lipid Res"},{"key":"7005_CR120","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2013.03.022","volume":"66","author":"E Niki","year":"2014","unstructured":"Niki E. Role of vitamin e as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic Biol Med. 2014;66:3\u201312. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.03.022.","journal-title":"Free Radic Biol Med"},{"key":"7005_CR121","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8030069","author":"T Ishii","year":"2019","unstructured":"Ishii T, Warabi E. Mechanism of rapid nuclear factor-e2-related factor 2 (NRF2) activation via membrane-associated Estrogen receptors: roles of NADPH oxidase 1, neutral Sphingomyelinase 2 and epidermal growth factor receptor (EGFR). Antioxidants. 2019. https:\/\/doi.org\/10.3390\/antiox8030069.","journal-title":"Antioxidants"},{"key":"7005_CR122","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3389\/fcell.2020.00559","volume":"8","author":"K Wang","year":"2020","unstructured":"Wang K, Zheng X, Pan Z, et al. Icariin prevents extracellular matrix accumulation and ameliorates experimental diabetic kidney disease by inhibiting oxidative stress via Gper mediated p62-dependent keap1 degradation and nrf2 activation. Front Cell Dev Biol. 2020;8:559. https:\/\/doi.org\/10.3389\/fcell.2020.00559.","journal-title":"Front Cell Dev Biol"},{"key":"7005_CR123","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345","author":"V Ngo","year":"2022","unstructured":"Ngo V, Duennwald ML. Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease. Antioxidants. 2022. https:\/\/doi.org\/10.3390\/antiox11122345.","journal-title":"Antioxidants"},{"issue":"5","key":"7005_CR124","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.3892\/ol.2015.3711","volume":"10","author":"AH Kurt","year":"2015","unstructured":"Kurt AH, \u00c7elik A, Kelleci BM. Oxidative\/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells. Oncol Lett. 2015;10(5):3177\u201382. https:\/\/doi.org\/10.3892\/ol.2015.3711.","journal-title":"Oncol Lett"},{"key":"7005_CR125","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.579161","volume":"11","author":"A Imam Aliagan","year":"2020","unstructured":"Imam Aliagan A, Madungwe NB, Tombo N, et al. Chronic GPER1 activation protects against oxidative stress-induced cardiomyoblast death via preservation of mitochondrial integrity and deactivation of mammalian sterile-20-like kinase\/yes-associated protein pathway. Front Endocrinol (Lausanne). 2020;11: 579161. https:\/\/doi.org\/10.3389\/fendo.2020.579161.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR126","doi-asserted-by":"publisher","first-page":"794332","DOI":"10.3389\/fendo.2021.794332","volume":"12","author":"Y Jacquot","year":"2021","unstructured":"Jacquot Y, Kampa M, Lindsey SH, Editorial. Gper and human pathologies. Front Endocrinol (Lausanne). 2021;12:794332. https:\/\/doi.org\/10.3389\/fendo.2021.794332.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114980","volume":"258","author":"Q Liu","year":"2023","unstructured":"Liu Q, Liu Y, Li X, et al. Perfluoroalkyl substances promote breast cancer progression via er\u03b1 and Gper mediated pi3k\/akt and mapk\/erk signaling pathways. Ecotoxicol Environ Saf. 2023;258: 114980. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114980.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"7005_CR128","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3164\/jcbn.20-56","volume":"67","author":"K Tanaka","year":"2020","unstructured":"Tanaka K, Ao M, Kuwabara A. Insufficiency of b vitamins with its possible clinical implications. J Clin Biochem Nutr. 2020;67(1):19\u201325. https:\/\/doi.org\/10.3164\/jcbn.20-56.","journal-title":"J Clin Biochem Nutr"},{"key":"7005_CR129","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.dib.2016.11.057","volume":"10","author":"H Wang","year":"2017","unstructured":"Wang H, Sun X, Chou J, et al. Inflammatory and mitochondrial gene expression data in gper-deficient cardiomyocytes from male and female mice. Data Brief. 2017;10:465\u201373. https:\/\/doi.org\/10.1016\/j.dib.2016.11.057.","journal-title":"Data Brief"},{"issue":"12","key":"7005_CR130","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22603","volume":"34","author":"X Lv","year":"2020","unstructured":"Lv X, Miao C, Liu M, et al. 17\u03b2-estradiol via orai1 activates calcium mobilization to induce cell proliferation in epithelial ovarian cancer. J Biochem Mol Toxicol. 2020;34(12): e22603. https:\/\/doi.org\/10.1002\/jbt.22603.","journal-title":"J Biochem Mol Toxicol"},{"key":"7005_CR131","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41413-019-0059-6","volume":"7","author":"J Luo","year":"2019","unstructured":"Luo J, Sun P, Siwko S, et al. The role of GPCRs in bone diseases and dysfunctions. Bone Res. 2019;7:19. https:\/\/doi.org\/10.1038\/s41413-019-0059-6.","journal-title":"Bone Res"},{"issue":"5","key":"7005_CR132","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1159\/000354252","volume":"50","author":"A Holm","year":"2013","unstructured":"Holm A, Hellstrand P, Olde B, et al. The g protein-coupled Estrogen receptor 1 (gper1\/gpr30) agonist g-1 regulates vascular smooth muscle cell ca\u00b2\u207a handling. J Vasc Res. 2013;50(5):421\u20139. https:\/\/doi.org\/10.1159\/000354252.","journal-title":"J Vasc Res"},{"key":"7005_CR133","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jsbmb.2018.09.013","volume":"185","author":"M Bauz\u00e1-Thorbr\u00fcgge","year":"2019","unstructured":"Bauz\u00e1-Thorbr\u00fcgge M, Rodr\u00edguez-Cuenca S, Vidal-Puig A, et al. Gper and er\u03b1 mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a Pka dependent mechanism. J Steroid Biochem Mol Biol. 2019;185:256\u201367. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.09.013.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"7005_CR134","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.mce.2013.11.005","volume":"382","author":"SB Cheng","year":"2014","unstructured":"Cheng SB, Dong J, Pang Y, et al. Anatomical location and redistribution of g protein-coupled Estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 2014;382(2):950\u20139. https:\/\/doi.org\/10.1016\/j.mce.2013.11.005.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104998","volume":"113","author":"A Manaithiya","year":"2021","unstructured":"Manaithiya A, Alam O, Sharma V, et al. Gpr119 agonists: novel therapeutic agents for type 2 diabetes mellitus. Bioorg Chem. 2021;113: 104998. https:\/\/doi.org\/10.1016\/j.bioorg.2021.104998.","journal-title":"Bioorg Chem"},{"issue":"6","key":"7005_CR136","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.22092\/ari.2022.358736.2294","volume":"77","author":"N Shamki Fayyad","year":"2022","unstructured":"Shamki Fayyad N, Risan Al-Rikabi H. Angiotensin-converting enzyme 2 (ace2) gene polymorphism in patients with type 2 diabetes (t2dm) in thi-qar, Iraq. Arch Razi Inst. 2022;77(6):2365\u201370. https:\/\/doi.org\/10.22092\/ari.2022.358736.2294.","journal-title":"Arch Razi Inst"},{"key":"7005_CR137","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105260","author":"JC Hixon","year":"2024","unstructured":"Hixon JC, Rivas Zarete JI, White J, et al. Epigenetic modulation of Gper expression in gastric and colonic smooth muscle of male and female non-obese diabetic (nod) mice: insights into h3k4me3 and h3k27ac modifications. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25105260.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"7005_CR138","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1124\/jpet.120.000216","volume":"376","author":"Q Wang","year":"2021","unstructured":"Wang Q, Li Z, Liu K, et al. Activation of the g protein-coupled estrogen receptor prevented the development of acute colitis by protecting the crypt cell. J Pharmacol Exp Ther. 2021;376(2):281\u201393. https:\/\/doi.org\/10.1124\/jpet.120.000216.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"7005_CR139","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s40200-023-01257-7","volume":"22","author":"M Sanjari","year":"2023","unstructured":"Sanjari M, Yarmohammadi H, Fahimfar N, et al. Mind the osteoporosis care gap with timely diagnosis: an executive summary of nationwide osteoporosis campaigns 2019\u20132021. J Diabetes Metab Disord. 2023;22(2):1365\u201372. https:\/\/doi.org\/10.1007\/s40200-023-01257-7.","journal-title":"J Diabetes Metab Disord"},{"issue":"2","key":"7005_CR140","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10253","volume":"4","author":"E Parle","year":"2020","unstructured":"Parle E, Tio S, Behre A, et al. Bone mineral is more heterogeneously distributed in the femoral heads of osteoporotic and diabetic patients: a pilot study. JBMR Plus. 2020;4(2): e10253. https:\/\/doi.org\/10.1002\/jbm4.10253.","journal-title":"JBMR Plus"},{"key":"7005_CR141","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101752","author":"D De Leon-Oliva","year":"2023","unstructured":"De Leon-Oliva D, Barrena-Bl\u00e1zquez S, Jim\u00e9nez-\u00c1lvarez L, et al. The rank-rankl-opg system: a multifaceted regulator of homeostasis, immunity, and cancer. Medicina (B Aires). 2023. https:\/\/doi.org\/10.3390\/medicina59101752.","journal-title":"Medicina (B Aires)"},{"issue":"2","key":"7005_CR142","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/s8756-3282(02)00953-5","volume":"32","author":"S Bord","year":"2003","unstructured":"Bord S, Ireland DC, Beavan SR, et al. The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts. Bone. 2003;32(2):136\u201341. https:\/\/doi.org\/10.1016\/s8756-3282(02)00953-5.","journal-title":"Bone"},{"issue":"10","key":"7005_CR143","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1002\/ptr.7939","volume":"37","author":"KY Wong","year":"2023","unstructured":"Wong KY, Kong TH, Poon CC, et al. Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of Estrogen receptors in osteoblasts. Phytother Res. 2023;37(10):4706\u201321. https:\/\/doi.org\/10.1002\/ptr.7939.","journal-title":"Phytother Res"},{"key":"7005_CR144","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052027","author":"S Chen","year":"2025","unstructured":"Chen S, Xiao J, Zhou S, et al. The gpr30-mediated bmp-6\/hep\/fpn signaling pathway inhibits ferroptosis in bone marrow mesenchymal stem cells to alleviate osteoporosis. Int J Mol Sci. 2025. https:\/\/doi.org\/10.3390\/ijms26052027.","journal-title":"Int J Mol Sci"},{"key":"7005_CR145","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00537","volume":"11","author":"R Llorente","year":"2020","unstructured":"Llorente R, Marraudino M, Carrillo B, et al. G protein-coupled estrogen receptor immunoreactivity fluctuates during the estrous cycle and show sex differences in the amygdala and dorsal hippocampus. Front Endocrinol (Lausanne). 2020;11: 537. https:\/\/doi.org\/10.3389\/fendo.2020.00537.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"7005_CR146","doi-asserted-by":"publisher","first-page":"124","DOI":"10.14715\/cmb\/2022.68.6.20","volume":"68","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Jiang T, Ni S, et al. Effects of Estrogen on proliferation and apoptosis of osteoblasts through regulating gper\/akt pathway. Cell Mol Biol (Noisy-le-grand). 2022;68(6):124\u20139. https:\/\/doi.org\/10.14715\/cmb\/2022.68.6.20.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"2","key":"7005_CR147","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/jbmr.209","volume":"26","author":"J Ford","year":"2011","unstructured":"Ford J, Hajibeigi A, Long M, et al. Gpr30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice. J Bone Miner Res. 2011;26(2):298\u2013307. https:\/\/doi.org\/10.1002\/jbmr.209.","journal-title":"J Bone Miner Res"},{"key":"7005_CR148","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jsbmb.2015.07.002","volume":"154","author":"WB Kang","year":"2015","unstructured":"Kang WB, Deng YT, Wang DS, et al. Osteoprotective effects of estrogen membrane receptor gpr30 in ovariectomized rats. J Steroid Biochem Mol Biol. 2015;154:237\u201344. https:\/\/doi.org\/10.1016\/j.jsbmb.2015.07.002.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"20","key":"7005_CR149","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1177\/15353702231198067","volume":"248","author":"Y Xue","year":"2023","unstructured":"Xue Y, Liu GM, Ke DS, et al. Gper1 contributes to t3-induced osteogenesis by mediating Glycolysis in osteoblast precursors. Exp Biol Med (Maywood). 2023;248(20):1732\u201344. https:\/\/doi.org\/10.1177\/15353702231198067.","journal-title":"Exp Biol Med (Maywood)"},{"key":"7005_CR150","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.578194","volume":"11","author":"NS Alekos","year":"2020","unstructured":"Alekos NS, Moorer MC, Riddle RC. Dual effects of lipid metabolism on osteoblast function. Front Endocrinol (Lausanne). 2020;11: 578194. https:\/\/doi.org\/10.3389\/fendo.2020.578194.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"7005_CR151","doi-asserted-by":"publisher","first-page":"209","DOI":"10.7570\/jomes21043","volume":"30","author":"KW Kim","year":"2021","unstructured":"Kim KW. Unravelling polycystic ovary syndrome and its comorbidities. J Obes Metab Syndr. 2021;30(3):209\u201321. https:\/\/doi.org\/10.7570\/jomes21043.","journal-title":"J Obes Metab Syndr"},{"key":"7005_CR152","unstructured":"Kotori M, Ferizi-Shabani L, Ko\u00e7inaj A et al. Clinical and endocrine alterations in women with polycystic ovary syndrome. Georgian Med News, 2024, (346): 10\u20133."},{"issue":"4","key":"7005_CR153","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.ncrna.2024.05.003","volume":"9","author":"X Lin","year":"2024","unstructured":"Lin X, Nie X, Deng P, et al. Whispers of the polycystic ovary syndrome theater: directing role of long noncoding RNAs. Noncoding RNA Res. 2024;9(4):1023\u201332. https:\/\/doi.org\/10.1016\/j.ncrna.2024.05.003.","journal-title":"Noncoding RNA Res"},{"issue":"3","key":"7005_CR154","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3109\/19396368.2016.1164260","volume":"62","author":"L Zang","year":"2016","unstructured":"Zang L, Zhang Q, Zhou Y, et al. Expression pattern of g protein\u2013coupled estrogen receptor 1 (gper) in human cumulus granulosa cells (cgcs) of patients with Pcos. Syst Biol Reprod Med. 2016;62(3):184\u201391. https:\/\/doi.org\/10.3109\/19396368.2016.1164260.","journal-title":"Syst Biol Reprod Med"},{"key":"7005_CR155","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.827032","volume":"13","author":"XL Xu","year":"2022","unstructured":"Xu XL, Huang ZY, Yu K, et al. Estrogen biosynthesis and signal transduction in ovarian disease. Front Endocrinol (Lausanne). 2022;13: 827032. https:\/\/doi.org\/10.3389\/fendo.2022.827032.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR156","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020459","author":"XL Xu","year":"2021","unstructured":"Xu XL, Deng SL, Lian ZX, et al. Estrogen receptors in polycystic ovary syndrome. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10020459.","journal-title":"Cells"},{"issue":"2","key":"7005_CR157","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1210\/jc.2015-3803","volume":"101","author":"M Hulchiy","year":"2016","unstructured":"Hulchiy M, Nybacka \u00c5, Sahlin L, et al. Endometrial expression of estrogen receptors and the androgen receptor in women with polycystic ovary syndrome: a lifestyle intervention study. J Clin Endocrinol Metab. 2016;101(2):561\u201371. https:\/\/doi.org\/10.1210\/jc.2015-3803.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"7005_CR158","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/cbin.10243","volume":"38","author":"H Liu","year":"2014","unstructured":"Liu H, Yan Y, Wen H, et al. A novel estrogen receptor Gper mediates proliferation induced by 17\u03b2-estradiol and selective Gper agonist g-1 in estrogen receptor \u03b1 (er\u03b1)-negative ovarian cancer cells. Cell Biol Int. 2014;38(5):631\u20138. https:\/\/doi.org\/10.1002\/cbin.10243.","journal-title":"Cell Biol Int"},{"issue":"1","key":"7005_CR159","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13293-024-00586-3","volume":"15","author":"AC Horton","year":"2024","unstructured":"Horton AC, Wilkinson MM, Kilanowski-Doroh I, et al. Dihydrotestosterone induces arterial stiffening in female mice. Biol Sex Differ. 2024;15(1):9. https:\/\/doi.org\/10.1186\/s13293-024-00586-3.","journal-title":"Biol Sex Differ"},{"key":"7005_CR160","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083923","author":"SA Dabravolski","year":"2021","unstructured":"Dabravolski SA, Nikiforov NG, Eid AH, et al. Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22083923.","journal-title":"Int J Mol Sci"},{"key":"7005_CR161","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073789","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, Suchta K, Grymowicz M, et al. Chronic low grade inflammation in pathogenesis of Pcos. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22073789.","journal-title":"Int J Mol Sci"},{"key":"7005_CR162","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115470","volume":"167","author":"Y Feng","year":"2023","unstructured":"Feng Y, Tang Z, Zhang W. The role of macrophages in polycystic ovarian syndrome and its typical pathological features: a narrative review. Biomed Pharmacother. 2023;167: 115470. https:\/\/doi.org\/10.1016\/j.biopha.2023.115470.","journal-title":"Biomed Pharmacother"},{"key":"7005_CR163","doi-asserted-by":"publisher","first-page":"1445634","DOI":"10.3389\/fimmu.2024.1445634","volume":"15","author":"M Cebi","year":"2024","unstructured":"Cebi M, Yilmaz Y. Immune system dysregulation in the pathogenesis of non-alcoholic steatohepatitis: unveiling the critical role of t and b lymphocytes. Front Immunol. 2024;15:1445634. https:\/\/doi.org\/10.3389\/fimmu.2024.1445634.","journal-title":"Front Immunol"},{"issue":"8","key":"7005_CR164","doi-asserted-by":"publisher","first-page":"e67151","DOI":"10.7759\/cureus.67151","volume":"16","author":"SM Anasdeen","year":"2024","unstructured":"Anasdeen SM, Tm SS. Evaluating bempedoic acid for non-alcoholic fatty liver disease: A review of preclinical and clinical research. Cureus. 2024;16(8):e67151. https:\/\/doi.org\/10.7759\/cureus.67151.","journal-title":"Cureus"},{"issue":"1","key":"7005_CR165","doi-asserted-by":"publisher","DOI":"10.3390\/pr9010135","volume":"9","author":"A Caturano","year":"2021","unstructured":"Caturano A, Acierno C, Nevola R, et al. Non-alcoholic fatty liver disease: from pathogenesis to clinical impact. Processes. 2021;9(1): 135. https:\/\/doi.org\/10.3390\/pr9010135.","journal-title":"Processes"},{"issue":"12","key":"7005_CR166","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.lpm.2019.09.051","volume":"48","author":"R Anty","year":"2019","unstructured":"Anty R, Gual P. Physiopathologie des st\u00e9atoses h\u00e9patiques m\u00e9taboliques. Presse Med. 2019;48(12):1468\u201383. https:\/\/doi.org\/10.1016\/j.lpm.2019.09.051.","journal-title":"Presse Med"},{"issue":"11","key":"7005_CR167","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.2174\/1871530322666220408123746","volume":"22","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wu J, Shi A. Literature review on the use of herbal extracts in the treatment of non- alcoholic fatty liver disease. Endocr Metab Immune Disord Drug Targets. 2022;22(11):1123\u201345. https:\/\/doi.org\/10.2174\/1871530322666220408123746.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"3","key":"7005_CR168","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105661","volume":"300","author":"L Li","year":"2024","unstructured":"Li L, Yao Y, Wang Y, et al. G protein-coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting ampk-dependent signaling. J Biol Chem. 2024;300(3): 105661. https:\/\/doi.org\/10.1016\/j.jbc.2024.105661.","journal-title":"J Biol Chem"},{"issue":"3","key":"7005_CR169","doi-asserted-by":"publisher","first-page":"401","DOI":"10.33594\/000000227","volume":"54","author":"S Farruggio","year":"2020","unstructured":"Farruggio S, Cocomazzi G, Marotta P, et al. Genistein and 17\u03b2-estradiol protect hepatocytes from fatty degeneration by mechanisms involving mitochondria, inflammasome and kinases activation. Cell Physiol Biochem. 2020;54(3):401\u201316. https:\/\/doi.org\/10.33594\/000000227.","journal-title":"Cell Physiol Biochem"},{"key":"7005_CR170","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.molimm.2023.01.008","volume":"155","author":"Y Yao","year":"2023","unstructured":"Yao Y, Wang H, Yang Y, et al. Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the ampk-nrf2 axis by targeting gpr30 in hepatocytes. Mol Immunol. 2023;155:110\u201323. https:\/\/doi.org\/10.1016\/j.molimm.2023.01.008.","journal-title":"Mol Immunol"},{"issue":"1","key":"7005_CR171","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s13105-021-00846-5","volume":"78","author":"Z Li","year":"2022","unstructured":"Li Z, Chen L, Chu H, et al. Estrogen alleviates hepatocyte necroptosis depending on Gper in hepatic ischemia reperfusion injury. J Physiol Biochem. 2022;78(1):125\u201337. https:\/\/doi.org\/10.1007\/s13105-021-00846-5.","journal-title":"J Physiol Biochem"},{"issue":"2","key":"7005_CR172","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.canlet.2016.08.012","volume":"382","author":"T Wei","year":"2016","unstructured":"Wei T, Chen W, Wen L, et al. G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis. Cancer Lett. 2016;382(2):195\u2013202. https:\/\/doi.org\/10.1016\/j.canlet.2016.08.012.","journal-title":"Cancer Lett"},{"issue":"11","key":"7005_CR173","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.22038\/ijbms.2020.42115.9957","volume":"23","author":"D Mahdian","year":"2020","unstructured":"Mahdian D, Abbaszadeh-Goudarzi K, Raoofi A, et al. Effect of Boswellia species on the metabolic syndrome: a review. Iran J Basic Med Sci. 2020;23(11):1374\u201381. https:\/\/doi.org\/10.22038\/ijbms.2020.42115.9957.","journal-title":"Iran J Basic Med Sci"},{"issue":"11","key":"7005_CR174","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1210\/en.2013-1357","volume":"154","author":"G Sharma","year":"2013","unstructured":"Sharma G, Hu C, Brigman JL, et al. Gper deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology. 2013;154(11):4136\u201345. https:\/\/doi.org\/10.1210\/en.2013-1357.","journal-title":"Endocrinology"},{"key":"7005_CR175","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122211","volume":"334","author":"W He","year":"2023","unstructured":"He W, Gao Z, Liu S, et al. G protein-coupled estrogen receptor activation by bisphenol-a disrupts lipid metabolism and induces ferroptosis in the liver. Environ Pollut. 2023;334: 122211. https:\/\/doi.org\/10.1016\/j.envpol.2023.122211.","journal-title":"Environ Pollut"},{"key":"7005_CR176","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2025.108801","volume":"267","author":"Z Wang","year":"2025","unstructured":"Wang Z, Liu J, Chen Y, et al. From physiology to pathology: emerging roles of Gper in cardiovascular disease. Pharmacol Ther. 2025;267: 108801. https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108801.","journal-title":"Pharmacol Ther"},{"key":"7005_CR177","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/tcrm.S232033","volume":"16","author":"A Albu","year":"2020","unstructured":"Albu A, Para I, Porojan M. Uric acid and arterial stiffness. Ther Clin Risk Manag. 2020;16:39\u201354. https:\/\/doi.org\/10.2147\/tcrm.S232033.","journal-title":"Ther Clin Risk Manag"},{"issue":"10","key":"7005_CR178","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.015110","volume":"9","author":"EY Gohar","year":"2020","unstructured":"Gohar EY, Daugherty EM, Aceves JO, et al. Evidence for G-protein-coupled estrogen receptor as a pronatriuretic factor. J Am Heart Assoc. 2020;9(10): e015110. https:\/\/doi.org\/10.1161\/jaha.119.015110.","journal-title":"J Am Heart Assoc"},{"key":"7005_CR179","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116116","volume":"222","author":"MJ Lee","year":"2024","unstructured":"Lee MJ, Kim J. The pathophysiology of visceral adipose tissues in cardiometabolic diseases. Biochem Pharmacol. 2024;222: 116116. https:\/\/doi.org\/10.1016\/j.bcp.2024.116116.","journal-title":"Biochem Pharmacol"},{"key":"7005_CR180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179532","author":"SE Son","year":"2024","unstructured":"Son SE, Im DS. Activation of g protein-coupled Estrogen receptor 1 (gper) attenuates obesity-induced asthma by switching M1 macrophages to M2 macrophages. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25179532.","journal-title":"Int J Mol Sci"},{"key":"7005_CR181","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ygcen.2013.07.004","volume":"193","author":"P Zhu","year":"2013","unstructured":"Zhu P, Yuen JM, Sham KW, et al. Gper mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion. Gen Comp Endocrinol. 2013;193:19\u201326. https:\/\/doi.org\/10.1016\/j.ygcen.2013.07.004.","journal-title":"Gen Comp Endocrinol"},{"key":"7005_CR182","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.bbi.2020.04.005","volume":"88","author":"MX Pan","year":"2020","unstructured":"Pan MX, Li J, Ma C, et al. Sex-dependent effects of Gper activation on neuroinflammation in a rat model of traumatic brain injury. Brain Behav Immun. 2020;88:421\u201331. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.005.","journal-title":"Brain Behav Immun"},{"key":"7005_CR183","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201846556","author":"E Cortes","year":"2019","unstructured":"Cortes E, Sarper M, Robinson B, et al. Gper is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. 2019. https:\/\/doi.org\/10.15252\/embr.201846556.","journal-title":"EMBO Rep"},{"issue":"10","key":"7005_CR184","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1016\/j.pec.2021.03.008","volume":"104","author":"J Liu","year":"2021","unstructured":"Liu J, Patterson S, Goel S, et al. Helping young women go red: harnessing the power of personal and digital information to prevent heart disease. Patient Educ Couns. 2021;104(10):2571\u20136. https:\/\/doi.org\/10.1016\/j.pec.2021.03.008.","journal-title":"Patient Educ Couns"},{"key":"7005_CR185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2020.100028","volume":"2","author":"P Elder","year":"2020","unstructured":"Elder P, Sharma G, Gulati M, et al. Identification of female-specific risk enhancers throughout the lifespan of women to improve cardiovascular disease prevention. Am J Prev Cardiol. 2020;2: 100028. https:\/\/doi.org\/10.1016\/j.ajpc.2020.100028.","journal-title":"Am J Prev Cardiol"},{"key":"7005_CR186","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.15420\/ecr.2020.50","volume":"16","author":"N Arnold","year":"2021","unstructured":"Arnold N, Lechner K, Waldeyer C, et al. Inflammation and cardiovascular disease: the future. Eur Cardiol. 2021;16:e20. https:\/\/doi.org\/10.15420\/ecr.2020.50.","journal-title":"Eur Cardiol"},{"issue":"11","key":"7005_CR187","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s11886-023-01961-z","volume":"25","author":"L Behrooz","year":"2023","unstructured":"Behrooz L, Lenneman CG, Hamburg NM. Emerging medical therapies for the treatment of obesity in women with cardiovascular diseases. Curr Cardiol Rep. 2023;25(11):1475\u201388. https:\/\/doi.org\/10.1007\/s11886-023-01961-z.","journal-title":"Curr Cardiol Rep"},{"issue":"10292","key":"7005_CR188","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1016\/s0140-6736(21)00684-x","volume":"397","author":"B Vogel","year":"2021","unstructured":"Vogel B, Acevedo M, Appelman Y, et al. The lancet women and cardiovascular disease commission: reducing the global burden by 2030. Lancet. 2021;397(10292):2385\u2013438. https:\/\/doi.org\/10.1016\/s0140-6736(21)00684-x.","journal-title":"Lancet"},{"issue":"19","key":"7005_CR189","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1111\/bph.15521","volume":"178","author":"QN Dinh","year":"2021","unstructured":"Dinh QN, Vinh A, Arumugam TV, et al. G protein-coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex-specific manner? Br J Pharmacol. 2021;178(19):3849\u201363. https:\/\/doi.org\/10.1111\/bph.15521.","journal-title":"Br J Pharmacol"},{"issue":"2","key":"7005_CR190","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s12265-022-10315-z","volume":"16","author":"J Ma","year":"2023","unstructured":"Ma J, Hu J, Wang X, et al. Improvement of cardiovascular function in aging females by the prolonged activation of G protein-coupled estrogen receptor. J Cardiovasc Transl Res. 2023;16(2):371\u201381. https:\/\/doi.org\/10.1007\/s12265-022-10315-z.","journal-title":"J Cardiovasc Transl Res"},{"issue":"4","key":"7005_CR191","doi-asserted-by":"publisher","first-page":"H1440","DOI":"10.1152\/ajpheart.00804.2020","volume":"320","author":"P Singh","year":"2021","unstructured":"Singh P, O\u2019Toole TE, Conklin DJ, et al. Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity. Am J Physiol Heart Circ Physiol. 2021;320(4):H1440\u201355. https:\/\/doi.org\/10.1152\/ajpheart.00804.2020.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"7005_CR192","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120917","volume":"308","author":"P Peixoto","year":"2022","unstructured":"Peixoto P, Vieira-Alves I, Couto GK, et al. Sex differences in the participation of endothelial mediators and signaling pathways involved in the vasodilator effect of a selective Gper agonist in resistance arteries of gonadectomized Wistar rats. Life Sci. 2022;308: 120917. https:\/\/doi.org\/10.1016\/j.lfs.2022.120917.","journal-title":"Life Sci"},{"issue":"4","key":"7005_CR193","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/s1875-5364(24)60618-7","volume":"22","author":"W Yao","year":"2024","unstructured":"Yao W, Tao R, Wang K, et al. Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER\/SIRT1\/HMGB1 signaling pathway in type 1 diabetic rats. Chin J Nat Med. 2024;22(4):293\u2013306. https:\/\/doi.org\/10.1016\/s1875-5364(24)60618-7.","journal-title":"Chin J Nat Med"},{"issue":"9","key":"7005_CR194","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04886-6","volume":"80","author":"J Adu-Amankwaah","year":"2023","unstructured":"Adu-Amankwaah J, Bushi A, Tan R, et al. Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1\/PI3K signaling pathway. Cell Mol Life Sci. 2023;80(9): 246. https:\/\/doi.org\/10.1007\/s00018-023-04886-6.","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"7005_CR195","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1007\/s43032-023-01283-z","volume":"30","author":"DJ Orlicky","year":"2023","unstructured":"Orlicky DJ, Smith EE, Bok R, et al. Estrogen and androgen receptor status in uterosacral ligaments of women with pelvic organ prolapse stratified by the pelvic organ prolapse histology quantification system. Reprod Sci. 2023;30(12):3495\u2013506. https:\/\/doi.org\/10.1007\/s43032-023-01283-z.","journal-title":"Reprod Sci"},{"key":"7005_CR196","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175591","volume":"945","author":"A Dama","year":"2023","unstructured":"Dama A, Baggio C, Trevisi L, et al. Regulation of human endothelial cell migration by oral contraceptive estrogen receptor ligands. Eur J Pharmacol. 2023;945: 175591. https:\/\/doi.org\/10.1016\/j.ejphar.2023.175591.","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"7005_CR197","doi-asserted-by":"publisher","first-page":"405","DOI":"10.17219\/acem\/133484","volume":"30","author":"D Wang","year":"2021","unstructured":"Wang D, Wang M, Sun P, et al. Eplerenone inhibits oxidized low-density lipoprotein-induced proliferation and migration of vascular smooth muscle cells by downregulating Gper expression. Adv Clin Exp Med. 2021;30(4):405\u201312. https:\/\/doi.org\/10.17219\/acem\/133484.","journal-title":"Adv Clin Exp Med"},{"key":"7005_CR198","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118076","volume":"328","author":"M Zhang","year":"2024","unstructured":"Zhang M, Mao C, Dai Y, et al. Qixian granule inhibits ferroptosis in vascular endothelial cells by modulating trpml1 in the lysosome to prevent postmenopausal atherosclerosis. J Ethnopharmacol. 2024;328: 118076. https:\/\/doi.org\/10.1016\/j.jep.2024.118076.","journal-title":"J Ethnopharmacol"},{"key":"7005_CR199","doi-asserted-by":"publisher","first-page":"108494","DOI":"10.1016\/j.steroids.2019.108494","volume":"152","author":"M Barton","year":"2019","unstructured":"Barton M, Meyer MR, Prossnitz ER. Nox1 downregulators: a new class of therapeutics. Steroids. 2019;152:108494. https:\/\/doi.org\/10.1016\/j.steroids.2019.108494.","journal-title":"Steroids"},{"key":"7005_CR200","doi-asserted-by":"publisher","first-page":"108997","DOI":"10.1016\/j.steroids.2022.108997","volume":"183","author":"X Yu","year":"2022","unstructured":"Yu X, Nguyen P, Burns NC, et al. Activation of g protein-coupled Estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats. Steroids. 2022;183:108997. https:\/\/doi.org\/10.1016\/j.steroids.2022.108997.","journal-title":"Steroids"},{"issue":"4\u20136","key":"7005_CR201","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1089\/ars.2023.0284","volume":"40","author":"AL Gonzalez","year":"2024","unstructured":"Gonzalez AL, Dungan MM, Smart CD, et al. Inflammation resolution in the cardiovascular system: arterial hypertension, atherosclerosis, and ischemic heart disease. Antioxid Redox Signal. 2024;40(4\u20136):292\u2013316. https:\/\/doi.org\/10.1089\/ars.2023.0284.","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"7005_CR202","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jval.2023.12.007","volume":"27","author":"O Alagoz","year":"2024","unstructured":"Alagoz O, Zhang Y, Arroyo N, et al. Modeling thyroid cancer epidemiology in the united States using papillary thyroid carcinoma microsimulation model. Value Health. 2024;27(3):367\u201375. https:\/\/doi.org\/10.1016\/j.jval.2023.12.007.","journal-title":"Value Health"},{"issue":"6","key":"7005_CR203","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1055\/a-1562-3455","volume":"130","author":"A Machens","year":"2022","unstructured":"Machens A, Lorenz K, Weber F, et al. Clinical significance of coexistence of Hashimoto thyroiditis and graves\u2019 disease with differentiated and medullary thyroid cancer. Exp Clin Endocrinol Diabetes. 2022;130(6):381\u20135. https:\/\/doi.org\/10.1055\/a-1562-3455.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"7005_CR204","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2022.104007","volume":"96","author":"Q Xu","year":"2022","unstructured":"Xu Q, Zhou L, Ri H, et al. Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: an in vitro mechanistic investigation. Environ Toxicol Pharmacol. 2022;96: 104007. https:\/\/doi.org\/10.1016\/j.etap.2022.104007.","journal-title":"Environ Toxicol Pharmacol"},{"key":"7005_CR205","doi-asserted-by":"publisher","first-page":"117112","DOI":"10.1016\/j.lfs.2019.117112","volume":"241","author":"PA Manfroi","year":"2020","unstructured":"Manfroi PA, Bertoni APS, Furlanetto TW. Gper1 in the thyroid: A systematic review. Life Sci. 2020;241:117112. https:\/\/doi.org\/10.1016\/j.lfs.2019.117112.","journal-title":"Life Sci"},{"key":"7005_CR206","doi-asserted-by":"publisher","first-page":"111397","DOI":"10.1016\/j.mce.2021.111397","volume":"535","author":"APS Bertoni","year":"2021","unstructured":"Bertoni APS, Manfroi PA, Tomedi J, et al. The gene expression of gper1 is low in fresh samples of papillary thyroid carcinoma (ptc), and in Silico analysis. Mol Cell Endocrinol. 2021;535:111397. https:\/\/doi.org\/10.1016\/j.mce.2021.111397.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR207","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.992883","volume":"13","author":"L Jing","year":"2022","unstructured":"Jing L, Zhang Q. Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion. Front Endocrinol (Lausanne). 2022;13: 992883. https:\/\/doi.org\/10.3389\/fendo.2022.992883.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"7005_CR208","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1007\/s12010-022-03823-w","volume":"194","author":"Y Xiao","year":"2022","unstructured":"Xiao Y, Chen D. Er\u03b1, but not er\u03b2 and gper, mediates estradiol-induced secretion of Tsh in mouse pituitary. Appl Biochem Biotechnol. 2022;194(6):2492\u2013502. https:\/\/doi.org\/10.1007\/s12010-022-03823-w.","journal-title":"Appl Biochem Biotechnol"},{"key":"7005_CR209","doi-asserted-by":"publisher","first-page":"875125","DOI":"10.4061\/2011\/875125","volume":"2011","author":"AP Santin","year":"2011","unstructured":"Santin AP, Furlanetto TW. Role of Estrogen in thyroid function and growth regulation. J Thyroid Res. 2011;2011:875125. https:\/\/doi.org\/10.4061\/2011\/875125.","journal-title":"J Thyroid Res"},{"issue":"2","key":"7005_CR210","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1017\/s0007114521003962","volume":"127","author":"P Trayhurn","year":"2022","unstructured":"Trayhurn P. Adipokines. Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2022;127(2):161\u20134. https:\/\/doi.org\/10.1017\/s0007114521003962.","journal-title":"Br J Nutr"},{"key":"7005_CR211","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.psyneuen.2019.03.030","volume":"106","author":"JG Gregory","year":"2019","unstructured":"Gregory JG, Hawken ER, Angelis S, et al. Estradiol potentiates inhibitory synaptic transmission in the oval bed nucleus of the striaterminalis of male and female rats. Psychoneuroendocrinology. 2019;106:102\u201310. https:\/\/doi.org\/10.1016\/j.psyneuen.2019.03.030.","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"7005_CR212","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/cphy.c180009","volume":"9","author":"GB Bernasochi","year":"2019","unstructured":"Bernasochi GB, Bell JR, Simpson ER, et al. Impact of estrogens on the regulation of white, beige, and brown adipose tissue depots. Compr Physiol. 2019;9(2):457\u201375. https:\/\/doi.org\/10.1002\/cphy.c180009.","journal-title":"Compr Physiol"},{"issue":"1","key":"7005_CR213","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.yhbeh.2014.02.004","volume":"66","author":"KE Davis","year":"2014","unstructured":"Davis KE, Carstens EJ, Irani BG, et al. Sexually dimorphic role of g protein-coupled estrogen receptor (gper) in modulating energy homeostasis. Horm Behav. 2014;66(1):196\u2013207. https:\/\/doi.org\/10.1016\/j.yhbeh.2014.02.004.","journal-title":"Horm Behav"},{"key":"7005_CR214","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094727","author":"H Suzuki","year":"2024","unstructured":"Suzuki H, Fujiwara Y, Ariyani W, et al. 17\u03b2-estradiol (e2) activates matrix mineralization through genomic\/nongenomic pathways in mc3t3-e1 cells. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25094727.","journal-title":"Int J Mol Sci"},{"key":"7005_CR215","doi-asserted-by":"publisher","first-page":"1065263","DOI":"10.3389\/fendo.2022.1065263","volume":"13","author":"X Liu","year":"2022","unstructured":"Liu X, Zhang Z, Song Y, et al. An update on brown adipose tissue and obesity intervention: function, regulation and therapeutic implications. Front Endocrinol (Lausanne). 2022;13:1065263. https:\/\/doi.org\/10.3389\/fendo.2022.1065263.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7005_CR216","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2024.100556","volume":"14","author":"H Zhong","year":"2025","unstructured":"Zhong H, He L, Zhong W, et al. Jinxinkang granule alleviates chronic heart failure by enhancing GPER\/AMPK\/PCG-1\u03b1-mediated fatty acid oxidation. Pharmacol Res. 2025; 14. https:\/\/doi.org\/10.1016\/j.prmcm.2024.100556.","journal-title":"Pharmacol Res"},{"key":"7005_CR217","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.mce.2015.11.027","volume":"420","author":"M Sbert-Roig","year":"2016","unstructured":"Sbert-Roig M, Bauz\u00e1-Thorbr\u00fcgge M, Galm\u00e9s-Pascual BM, et al. Gper mediates the effects of 17\u03b2-estradiol in cardiac mitochondrial biogenesis and function. Mol Cell Endocrinol. 2016;420:116\u201324. https:\/\/doi.org\/10.1016\/j.mce.2015.11.027.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR218","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2021.105989","volume":"214","author":"ZR Du","year":"2021","unstructured":"Du ZR, Gu Y, Xie XM, et al. Gper and igf-1r mediate the anti-inflammatory effect of genistein against lipopolysaccharide (lps)-induced nigrostriatal injury in rats. J Steroid Biochem Mol Biol. 2021;214: 105989. https:\/\/doi.org\/10.1016\/j.jsbmb.2021.105989.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"7005_CR219","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cstres.2024.05.004","volume":"29","author":"Y Wang","year":"2024","unstructured":"Wang Y, Ren T, Li C, et al. Mechanisms involved in the regulation of mitochondrial quality control by pgam5 in heart failure. Cell Stress Chaperones. 2024;29(3):510\u20138. https:\/\/doi.org\/10.1016\/j.cstres.2024.05.004.","journal-title":"Cell Stress Chaperones"},{"key":"7005_CR220","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105807","volume":"207","author":"J Wang","year":"2021","unstructured":"Wang J, Li HY, Shen SY, et al. The antidepressant and anxiolytic effect of Gper on translocator protein (tspo) via protein kinase a (pka) signaling in menopausal female rats. J Steroid Biochem Mol Biol. 2021;207: 105807. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105807.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"7005_CR221","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091410","author":"F Xu","year":"2023","unstructured":"Xu F, Ma J, Wang X, et al. The role of g protein-coupled Estrogen receptor (gper) in vascular pathology and physiology. Biomolecules. 2023. https:\/\/doi.org\/10.3390\/biom13091410.","journal-title":"Biomolecules"},{"issue":"7","key":"7005_CR222","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102213","volume":"7","author":"V L\u00e9opold","year":"2023","unstructured":"L\u00e9opold V, Chouchane O, Butler JM, et al. Platelets of covid-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death. Res Pract Thromb Haemost. 2023;7(7): 102213. https:\/\/doi.org\/10.1016\/j.rpth.2023.102213.","journal-title":"Res Pract Thromb Haemost"},{"issue":"5","key":"7005_CR223","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00281-019-00757-0","volume":"41","author":"KH Park-Min","year":"2019","unstructured":"Park-Min KH. Metabolic reprogramming in osteoclasts. Semin Immunopathol. 2019;41(5):565\u201372. https:\/\/doi.org\/10.1007\/s00281-019-00757-0.","journal-title":"Semin Immunopathol"},{"issue":"44","key":"7005_CR224","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000040273","volume":"103","author":"B Zhu","year":"2024","unstructured":"Zhu B, Cheng L, Huang B, et al. Central role of hypoxia-inducible factor-1\u03b1 in metabolic reprogramming of cancer cells: a review. Medicine (Baltimore). 2024;103(44): e40273. https:\/\/doi.org\/10.1097\/md.0000000000040273.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"7005_CR225","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2023.2270654","volume":"40","author":"Y Yang","year":"2023","unstructured":"Yang Y, Huangfu L, Li H, et al. Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells. Int J Hyperthermia. 2023;40(1): 2270654. https:\/\/doi.org\/10.1080\/02656736.2023.2270654.","journal-title":"Int J Hyperthermia"},{"issue":"8","key":"7005_CR226","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1158\/2159-8290.Cd-22-0982","volume":"13","author":"AR Frank","year":"2023","unstructured":"Frank AR, Li V, Shelton SD, et al. Mitochondrial-encoded complex i impairment induces a targetable dependency on aerobic fermentation in H\u00fcrthle cell carcinoma of the thyroid. Cancer Discov. 2023;13(8):1884\u2013903. https:\/\/doi.org\/10.1158\/2159-8290.Cd-22-0982.","journal-title":"Cancer Discov"},{"issue":"15","key":"7005_CR227","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1038\/onc.2016.370","volume":"36","author":"T Yu","year":"2017","unstructured":"Yu T, Yang G, Hou Y, et al. Cytoplasmic Gper translocation in cancer-associated fibroblasts mediates camp\/pka\/creb\/glycolytic axis to confer tumor cells with multidrug resistance. Oncogene. 2017;36(15):2131\u201345. https:\/\/doi.org\/10.1038\/onc.2016.370.","journal-title":"Oncogene"},{"issue":"10","key":"7005_CR228","doi-asserted-by":"publisher","first-page":"e2207342","DOI":"10.1002\/adma.202207342","volume":"35","author":"J Lee","year":"2023","unstructured":"Lee J, Kim K, Kwon IC, et al. Intracellular glucose-depriving polymer micelles for antiglycolytic cancer treatment. Adv Mater. 2023;35(10):e2207342. https:\/\/doi.org\/10.1002\/adma.202207342.","journal-title":"Adv Mater"},{"key":"7005_CR229","doi-asserted-by":"publisher","unstructured":"Li L, Liang Y, Kang L et al. Transcriptional regulation of the warburg effect in cancer by six1. Cancer Cell, 2018, 33(3): 368\u2009\u2013\u200985.e7.https:\/\/doi.org\/10.1016\/j.ccell.2018.01.010","DOI":"10.1016\/j.ccell.2018.01.010"},{"issue":"3","key":"7005_CR230","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41388-022-02506-4","volume":"42","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Song Y, Ren S, et al. Gper-mediated stabilization of hif-1\u03b1 contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells. Oncogene. 2023;42(3):184\u201397. https:\/\/doi.org\/10.1038\/s41388-022-02506-4.","journal-title":"Oncogene"},{"issue":"6","key":"7005_CR231","doi-asserted-by":"publisher","first-page":"655","DOI":"10.4062\/biomolther.2023.072","volume":"31","author":"N Kim","year":"2023","unstructured":"Kim N, Kwon J, Shin US, et al. Stimulatory anticancer effect of Resveratrol mediated by g protein-coupled estrogen receptor in colorectal cancer. Biomol Ther (Seoul). 2023;31(6):655\u201360. https:\/\/doi.org\/10.4062\/biomolther.2023.072.","journal-title":"Biomol Ther (Seoul)"},{"issue":"1","key":"7005_CR232","doi-asserted-by":"publisher","first-page":"94","DOI":"10.18632\/oncotarget.6475","volume":"7","author":"DC Rigiracciolo","year":"2016","unstructured":"Rigiracciolo DC, Scarpelli A, Lappano R, et al. Gper is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells. Oncotarget. 2016;7(1):94\u2013111. https:\/\/doi.org\/10.18632\/oncotarget.6475.","journal-title":"Oncotarget"},{"key":"7005_CR233","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030672","author":"RA Pepermans","year":"2021","unstructured":"Pepermans RA, Sharma G, Prossnitz ER. G protein-coupled estrogen receptor in cancer and stromal cells: functions and novel therapeutic perspectives. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10030672.","journal-title":"Cells"},{"key":"7005_CR234","doi-asserted-by":"publisher","first-page":"109311","DOI":"10.1016\/j.steroids.2023.109311","volume":"200","author":"B Jouffre","year":"2023","unstructured":"Jouffre B, Acramel A, Jacquot Y, et al. Gper involvement in inflammatory pain. Steroids. 2023;200:109311. https:\/\/doi.org\/10.1016\/j.steroids.2023.109311.","journal-title":"Steroids"},{"issue":"6","key":"7005_CR235","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12693","volume":"21","author":"H Yang","year":"2021","unstructured":"Yang H, Wang C, Liao H, et al. Activation of Gper by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124\/CD151 pathway. Oncol Lett. 2021;21(6): 432. https:\/\/doi.org\/10.3892\/ol.2021.12693.","journal-title":"Oncol Lett"},{"key":"7005_CR236","doi-asserted-by":"publisher","first-page":"1458033","DOI":"10.3389\/fcimb.2024.1458033","volume":"14","author":"Z Wu","year":"2024","unstructured":"Wu Z, Sun Y, Huang W, et al. Direct and indirect effects of estrogens, androgens and intestinal microbiota on colorectal cancer. Front Cell Infect Microbiol. 2024;14:1458033. https:\/\/doi.org\/10.3389\/fcimb.2024.1458033.","journal-title":"Front Cell Infect Microbiol"},{"key":"7005_CR237","doi-asserted-by":"publisher","first-page":"1091779","DOI":"10.3389\/fphar.2022.1091779","volume":"13","author":"D Zhou","year":"2022","unstructured":"Zhou D, Duan Z, Li Z, et al. The significance of Glycolysis in tumor progression and its relationship with the tumor microenvironment. Front Pharmacol. 2022;13:1091779. https:\/\/doi.org\/10.3389\/fphar.2022.1091779.","journal-title":"Front Pharmacol"},{"key":"7005_CR238","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112369","volume":"136","author":"H Dong","year":"2024","unstructured":"Dong H, Zeng X, Xu J, et al. Advances in immune regulation of the G protein-coupled estrogen receptor. Int Immunopharmacol. 2024;136: 112369. https:\/\/doi.org\/10.1016\/j.intimp.2024.112369.","journal-title":"Int Immunopharmacol"},{"key":"7005_CR239","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skad197","author":"L Li","year":"2023","unstructured":"Li L, Wang Y, Wang H, et al. Protective effects of genistein on the production performance and lipid metabolism disorders in laying hens with fatty liver hemorrhagic syndrome by activation of the GPER-AMPK signaling pathways. J Anim Sci. 2023. https:\/\/doi.org\/10.1093\/jas\/skad197.","journal-title":"J Anim Sci"},{"key":"7005_CR240","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914993","author":"AC Tirado-Garibay","year":"2023","unstructured":"Tirado-Garibay AC, Falc\u00f3n-Ruiz EA, Ochoa-Zarzosa A, et al. Gper: an estrogen receptor key in metastasis and tumoral microenvironments. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241914993.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"7005_CR241","doi-asserted-by":"publisher","first-page":"138","DOI":"10.20517\/cdr.2022.133","volume":"6","author":"Y Tabe","year":"2023","unstructured":"Tabe Y, Konopleva M. Resistance to energy metabolism - targeted therapy of aml cells residual in the bone marrow microenvironment. Cancer Drug Resist. 2023;6(1):138\u201350. https:\/\/doi.org\/10.20517\/cdr.2022.133.","journal-title":"Cancer Drug Resist"},{"issue":"24","key":"7005_CR242","doi-asserted-by":"publisher","first-page":"10494","DOI":"10.1021\/acs.est.4c01602","volume":"58","author":"X Liu","year":"2024","unstructured":"Liu X, Cheng Z, Shang X, et al. New mechanism for the apoptosis of human neuroblastoma cells by the interaction between fluorene-9-bisphenol and the G protein-coupled Estrogen receptor 1. Environ Sci Technol. 2024;58(24):10494\u2013503. https:\/\/doi.org\/10.1021\/acs.est.4c01602.","journal-title":"Environ Sci Technol"},{"key":"7005_CR243","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jsbmb.2014.05.003","volume":"143","author":"T Yu","year":"2014","unstructured":"Yu T, Liu M, Luo H, et al. Gper mediates enhanced cell viability and motility via non-genomic signaling induced by 17\u03b2-estradiol in triple-negative breast cancer cells. J Steroid Biochem Mol Biol. 2014;143:392\u2013403. https:\/\/doi.org\/10.1016\/j.jsbmb.2014.05.003.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"7005_CR244","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040838","author":"M Weiler","year":"2023","unstructured":"Weiler M, Hertzler SR, Dvoretskiy S. Is it time to reconsider the U.S. recommendations for dietary protein and amino acid intake? Nutrients. 2023. https:\/\/doi.org\/10.3390\/nu15040838.","journal-title":"Nutrients"},{"issue":"1","key":"7005_CR245","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1186\/s12889-023-16468-z","volume":"23","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang H, Liang Y, et al. Dietary intakes of methionine, threonine, lysine, arginine and histidine increased risk of type 2 diabetes in Chinese population: does the mediation effect of obesity exist? BMC Public Health. 2023;23(1):1551. https:\/\/doi.org\/10.1186\/s12889-023-16468-z.","journal-title":"BMC Public Health"},{"issue":"6","key":"7005_CR246","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/1873-3468.70030","volume":"599","author":"A Gupta","year":"2025","unstructured":"Gupta A, Shinde PG, Jorvekar S, et al. G protein-coupled oestrogen receptor regulates branched-chain amino acid metabolism through c-jun n-terminal kinase. FEBS Lett. 2025;599(6):892\u2013900. https:\/\/doi.org\/10.1002\/1873-3468.70030.","journal-title":"FEBS Lett"},{"key":"7005_CR247","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.70030","author":"A Gupta","year":"2025","unstructured":"Gupta A, Shinde PG, Jorvekar S, et al. G protein-coupled oestrogen receptor regulates branched-chain amino acid metabolism through c-jun n-terminal kinase. FEBS Lett. 2025. https:\/\/doi.org\/10.1002\/1873-3468.70030.","journal-title":"FEBS Lett"},{"issue":"12","key":"7005_CR248","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1007\/s00432-020-03333-4","volume":"146","author":"S Sch\u00fcler-Toprak","year":"2020","unstructured":"Sch\u00fcler-Toprak S, Skrzypczak M, Ignatov T, et al. G protein-coupled Estrogen receptor 1 (gper-1) and agonist g-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of gper-1 Mrna on survival. J Cancer Res Clin Oncol. 2020;146(12):3175\u201388. https:\/\/doi.org\/10.1007\/s00432-020-03333-4.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"7005_CR249","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.celrep.2013.10.006","volume":"5","author":"Q Wu","year":"2013","unstructured":"Wu Q, Ishikawa T, Sirianni R, et al. 27-hydroxycholesterol promotes cell-autonomous, er-positive breast cancer growth. Cell Rep. 2013;5(3):637\u201345. https:\/\/doi.org\/10.1016\/j.celrep.2013.10.006.","journal-title":"Cell Rep"},{"issue":"8","key":"7005_CR250","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1158\/2767-9764.Crc-22-0478","volume":"3","author":"I Lee","year":"2023","unstructured":"Lee I, Doepner M, Weissenrieder J, et al. Lns8801 inhibits acute myeloid leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway. Cancer Res Commun. 2023;3(8):1594\u2013606. https:\/\/doi.org\/10.1158\/2767-9764.Crc-22-0478.","journal-title":"Cancer Res Commun"},{"issue":"10","key":"7005_CR251","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/s41419-022-05357-9","volume":"13","author":"J Ren","year":"2022","unstructured":"Ren J, Tao Y, Peng M, et al. Targeted activation of Gper enhances the efficacy of venetoclax by boosting leukemic pyroptosis and cd8\u2009+\u2009t cell immune function in acute myeloid leukemia. Cell Death Dis. 2022;13(10):915. https:\/\/doi.org\/10.1038\/s41419-022-05357-9.","journal-title":"Cell Death Dis"},{"issue":"2","key":"7005_CR252","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","volume":"12","author":"D Du","year":"2022","unstructured":"Du D, Liu C, Qin M, et al. Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. Acta Pharm Sin B. 2022;12(2):558\u201380. https:\/\/doi.org\/10.1016\/j.apsb.2021.09.019.","journal-title":"Acta Pharm Sin B"},{"key":"7005_CR253","doi-asserted-by":"publisher","first-page":"1430465","DOI":"10.3389\/fnins.2024.1430465","volume":"18","author":"Y Cao","year":"2024","unstructured":"Cao Y, Zhao LW, Chen ZX, et al. New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer\u2019s disease. Front Neurosci. 2024;18:1430465. https:\/\/doi.org\/10.3389\/fnins.2024.1430465.","journal-title":"Front Neurosci"},{"key":"7005_CR254","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.761538","volume":"8","author":"W Qu","year":"2021","unstructured":"Qu W, Ma T, Cai J, et al. Liver fibrosis and mafld: from molecular aspects to novel pharmacological strategies. Front Med. 2021;8: 761538. https:\/\/doi.org\/10.3389\/fmed.2021.761538.","journal-title":"Front Med"},{"issue":"3","key":"7005_CR255","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00424-024-02909-0","volume":"476","author":"KB Assersen","year":"2024","unstructured":"Assersen KB, Jensen BL, Enggaard C, et al. Histamine h(2)-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II-hypertensive mice. Pflugers Arch. 2024;476(3):307\u201321. https:\/\/doi.org\/10.1007\/s00424-024-02909-0.","journal-title":"Pflugers Arch"},{"issue":"1","key":"7005_CR256","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/s41598-020-57819-9","volume":"10","author":"Y Deng","year":"2020","unstructured":"Deng Y, Miki Y, Nakanishi A. Estradiol\/GPER affects the integrity of mammary duct-like structures in vitro. Sci Rep. 2020;10(1):1386. https:\/\/doi.org\/10.1038\/s41598-020-57819-9.","journal-title":"Sci Rep"},{"key":"7005_CR257","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110762","volume":"506","author":"T Yu","year":"2020","unstructured":"Yu T, Cheng H, Ding Z, et al. Gper mediates decreased chemosensitivity via regulation of abcg2 expression and localization in tamoxifen-resistant breast cancer cells. Mol Cell Endocrinol. 2020;506: 110762. https:\/\/doi.org\/10.1016\/j.mce.2020.110762.","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"7005_CR258","doi-asserted-by":"publisher","first-page":"8051","DOI":"10.1007\/s00432-022-04501-4","volume":"149","author":"D Liu","year":"2023","unstructured":"Liu D, Wang H, Li X, et al. Small molecule inhibitors for cancer metabolism: promising prospects to be explored. J Cancer Res Clin Oncol. 2023;149(10):8051\u201376. https:\/\/doi.org\/10.1007\/s00432-022-04501-4.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"7005_CR259","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1158\/1078-0432.Ccr-08-1150","volume":"15","author":"P Pawar","year":"2009","unstructured":"Pawar P, Ma L, Byon CH, et al. Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin. Clin Cancer Res. 2009;15(4):1288\u201396. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-08-1150.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"7005_CR260","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3581","volume":"15","author":"Z Mo","year":"2013","unstructured":"Mo Z, Liu M, Yang F, et al. Gpr30 as an initiator of Tamoxifen resistance in hormone-dependent breast cancer. Breast Cancer Res. 2013;15(6): R114. https:\/\/doi.org\/10.1186\/bcr3581.","journal-title":"Breast Cancer Res"},{"issue":"5","key":"7005_CR261","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2174\/156800912800673284","volume":"12","author":"R Lappano","year":"2012","unstructured":"Lappano R, Rosano C, Santolla MF, et al. Two novel Gper agonists induce gene expression changes and growth effects in cancer cells. Curr Cancer Drug Targets. 2012;12(5):531\u201342. https:\/\/doi.org\/10.2174\/156800912800673284.","journal-title":"Curr Cancer Drug Targets"},{"key":"7005_CR262","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121860","volume":"328","author":"RA Hameed","year":"2023","unstructured":"Hameed RA, Ahmed EK, Mahmoud AA, et al. G protein-coupled estrogen receptor (gper) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism. Life Sci. 2023;328: 121860. https:\/\/doi.org\/10.1016\/j.lfs.2023.121860.","journal-title":"Life Sci"},{"issue":"5","key":"7005_CR263","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.995","volume":"10","author":"Q Ding","year":"2022","unstructured":"Ding Q, Chorazyczewski J, Gros R, et al. Correlation of functional and radioligand binding characteristics of Gper ligands confirming aldosterone as a Gper agonist. Pharmacol Res Perspect. 2022;10(5): e00995. https:\/\/doi.org\/10.1002\/prp2.995.","journal-title":"Pharmacol Res Perspect"},{"issue":"9","key":"7005_CR264","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1021\/acsmedchemlett.8b00212","volume":"9","author":"A O\u2019Dea","year":"2018","unstructured":"O\u2019Dea A, Sondergard C, Sweeney P, et al. A series of indole-thiazole derivatives act as Gper agonists and inhibit breast cancer cell growth. ACS Med Chem Lett. 2018;9(9):901\u20136. https:\/\/doi.org\/10.1021\/acsmedchemlett.8b00212.","journal-title":"ACS Med Chem Lett"},{"issue":"4","key":"7005_CR265","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1158\/2767-9764.Crc-22-0399","volume":"3","author":"G Ambrosini","year":"2023","unstructured":"Ambrosini G, Natale CA, Musi E, et al. The Gper agonist lns8801 induces mitotic arrest and apoptosis in uveal melanoma cells. Cancer Res Commun. 2023;3(4):540\u20137. https:\/\/doi.org\/10.1158\/2767-9764.Crc-22-0399.","journal-title":"Cancer Res Commun"},{"issue":"1","key":"7005_CR266","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13197","volume":"38","author":"C Marinaro","year":"2025","unstructured":"Marinaro C, Sauer J, Natale CA, et al. An in vivo study of lns8801, a Gper agonist, in a spontaneous melanoma-prone mouse model, Tgs. Pigment Cell Melanoma Res. 2025;38(1): e13197. https:\/\/doi.org\/10.1111\/pcmr.13197.","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"7005_CR267","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1161\/hypertensionaha.123.22024","volume":"81","author":"IM Kilanowski-Doroh","year":"2024","unstructured":"Kilanowski-Doroh IM, McNally AB, Wong TJ, et al. Ovariectomy-induced arterial stiffening differs from vascular aging and is reversed by Gper activation. Hypertension. 2024;81(5):e51\u2013e. https:\/\/doi.org\/10.1161\/hypertensionaha.123.22024.","journal-title":"Hypertension"},{"key":"7005_CR268","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082135","author":"T Nohara","year":"2023","unstructured":"Nohara T, Tsuji M, Oguchi T, et al. Neuroprotective potential of raloxifene via g-protein-coupled estrogen receptors in a\u03b2-oligomer-induced neuronal injury. Biomedicines. 2023. https:\/\/doi.org\/10.3390\/biomedicines11082135.","journal-title":"Biomedicines"},{"key":"7005_CR269","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mce.2016.04.011","volume":"429","author":"D Jacenik","year":"2016","unstructured":"Jacenik D, Cygankiewicz AI, Krajewska WM. The g protein-coupled Estrogen receptor as a modulator of neoplastic transformation. Mol Cell Endocrinol. 2016;429:10\u20138. https:\/\/doi.org\/10.1016\/j.mce.2016.04.011.","journal-title":"Mol Cell Endocrinol"},{"key":"7005_CR270","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.breast.2017.12.016","volume":"38","author":"A Di Leo","year":"2018","unstructured":"Di Leo A, Jerusalem G, Torres R, et al. First-line vs second-line fulvestrant for hormone receptor-positive advanced breast cancer: a post-hoc analysis of the confirm study. Breast. 2018;38:144\u20139. https:\/\/doi.org\/10.1016\/j.breast.2017.12.016.","journal-title":"Breast"},{"issue":"15","key":"7005_CR271","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1158\/1078-0432.Ccr-13-1378","volume":"20","author":"N Patani","year":"2014","unstructured":"Patani N, Dunbier AK, Anderson H, et al. Differences in the transcriptional response to fulvestrant and estrogen deprivation in er-positive breast cancer. Clin Cancer Res. 2014;20(15):3962\u201373. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-13-1378.","journal-title":"Clin Cancer Res"},{"key":"7005_CR272","doi-asserted-by":"publisher","unstructured":"Petrie WK, Dennis MK, Hu C et al. G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int, 2013, 2013: 472720.https:\/\/doi.org\/10.1155\/2013\/472720","DOI":"10.1155\/2013\/472720"},{"issue":"3","key":"7005_CR273","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.molonc.2013.02.012","volume":"7","author":"G Notas","year":"2013","unstructured":"Notas G, Kampa M, Pelekanou V, et al. Whole transcriptome analysis of the er\u03b1 synthetic fragment p295-t311 (er\u03b117p) identifies specific er\u03b1-isoform (er\u03b1, er\u03b136)-dependent and -independent actions in breast cancer cells. Mol Oncol. 2013;7(3):595\u2013610. https:\/\/doi.org\/10.1016\/j.molonc.2013.02.012.","journal-title":"Mol Oncol"},{"key":"7005_CR274","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060590","author":"R Lappano","year":"2019","unstructured":"Lappano R, Mallet C, Rizzuti B, et al. The peptide er\u03b117p is a Gper inverse agonist that exerts antiproliferative effects in breast cancer cells. Cells. 2019. https:\/\/doi.org\/10.3390\/cells8060590.","journal-title":"Cells"},{"issue":"12","key":"7005_CR275","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.1002\/jcb.23309","volume":"112","author":"M Kampa","year":"2011","unstructured":"Kampa M, Pelekanou V, Gallo D, et al. Er\u03b117p, an er\u03b1 p295 -t311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements. J Cell Biochem. 2011;112(12):3786\u201396. https:\/\/doi.org\/10.1002\/jcb.23309.","journal-title":"J Cell Biochem"},{"issue":"3\u20135","key":"7005_CR276","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.jsbmb.2011.07.002","volume":"127","author":"MK Dennis","year":"2011","unstructured":"Dennis MK, Field AS, Burai R, et al. Identification of a GPER\/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol. 2011;127(3\u20135):358\u201366. https:\/\/doi.org\/10.1016\/j.jsbmb.2011.07.002.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"7005_CR277","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3727\/096504017x15035795904677","volume":"27","author":"C Liu","year":"2019","unstructured":"Liu C, Liao Y, Fan S, et al. G-protein-coupled estrogen receptor antagonist g15 decreases estrogen-induced development of non-small cell lung cancer. Oncol Res. 2019;27(3):283\u201392. https:\/\/doi.org\/10.3727\/096504017x15035795904677.","journal-title":"Oncol Res"},{"key":"7005_CR278","doi-asserted-by":"publisher","first-page":"1276707","DOI":"10.3389\/fcell.2023.1276707","volume":"11","author":"H Zhang","year":"2023","unstructured":"Zhang H, Zhou H, Shen X, et al. The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions. Front Cell Dev Biol. 2023;11:1276707. https:\/\/doi.org\/10.3389\/fcell.2023.1276707.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"7005_CR279","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3096","volume":"14","author":"R Lappano","year":"2012","unstructured":"Lappano R, Santolla MF, Pupo M, et al. Mibe acts as antagonist ligand of both estrogen receptor \u03b1 and Gper in breast cancer cells. Breast Cancer Res. 2012;14(1): R12. https:\/\/doi.org\/10.1186\/bcr3096.","journal-title":"Breast Cancer Res"},{"issue":"5","key":"7005_CR280","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1194\/jlr.RA119000592","volume":"61","author":"C DeLeon","year":"2020","unstructured":"DeLeon C, Wang HH, Gunn J, et al. A novel Gper antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J Lipid Res. 2020;61(5):767\u201377. https:\/\/doi.org\/10.1194\/jlr.RA119000592.","journal-title":"J Lipid Res"},{"issue":"1\u20132","key":"7005_CR281","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.mce.2010.02.006","volume":"320","author":"R Lappano","year":"2010","unstructured":"Lappano R, Rosano C, De Marco P, et al. Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol. 2010;320(1\u20132):162\u201370. https:\/\/doi.org\/10.1016\/j.mce.2010.02.006.","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"7005_CR282","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1095\/biolreprod.114.125674","volume":"92","author":"TK Chourasia","year":"2015","unstructured":"Chourasia TK, Pang Y, Thomas P. The catecholestrogen, 2-hydroxyestradiol-17beta, acts as a g protein-coupled estrogen receptor 1 (gper\/gpr30) antagonist to promote the resumption of meiosis in zebrafish oocytes. Biol Reprod. 2015;92(3):69. https:\/\/doi.org\/10.1095\/biolreprod.114.125674.","journal-title":"Biol Reprod"},{"issue":"4","key":"7005_CR283","doi-asserted-by":"publisher","first-page":"437","DOI":"10.4155\/fmc.15.3","volume":"7","author":"M Maggiolini","year":"2015","unstructured":"Maggiolini M, Santolla MF, Avino S, et al. Identification of two benzopyrroloxazines acting as selective Gper antagonists in breast cancer cells and cancer-associated fibroblasts. Future Med Chem. 2015;7(4):437\u201348. https:\/\/doi.org\/10.4155\/fmc.15.3.","journal-title":"Future Med Chem"},{"key":"7005_CR284","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00012","volume":"6","author":"M Perri","year":"2019","unstructured":"Perri M, Aiello F, Cione E, et al. Investigation of TNBC in vitro antiproliferative effects of versatile pirrolo[1,2-a]quinoxaline compounds. Front Mol Biosci. 2019;6: 12. https:\/\/doi.org\/10.3389\/fmolb.2019.00012.","journal-title":"Front Mol Biosci"},{"issue":"16","key":"7005_CR285","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1002\/cmdc.201700145","volume":"12","author":"F Aiello","year":"2017","unstructured":"Aiello F, Carullo G, Giordano F, et al. Identification of breast cancer inhibitors specific for g\u2005protein-coupled estrogen receptor (gper)-expressing cells. ChemMedChem. 2017;12(16):1279\u201385. https:\/\/doi.org\/10.1002\/cmdc.201700145.","journal-title":"ChemMedChem"},{"issue":"10","key":"7005_CR286","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1242\/dmm.021071","volume":"8","author":"R Lappano","year":"2015","unstructured":"Lappano R, Rosano C, Pisano A, et al. A calixpyrrole derivative acts as an antagonist to gper, a g-protein coupled receptor: mechanisms and models. Dis Model Mech. 2015;8(10):1237\u201346. https:\/\/doi.org\/10.1242\/dmm.021071.","journal-title":"Dis Model Mech"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07005-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07005-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07005-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:34:30Z","timestamp":1756218870000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07005-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":286,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7005"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07005-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"31 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"960"}}