{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:54:58Z","timestamp":1757627698890,"version":"3.44.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009047","name":"Shantou University","doi-asserted-by":"publisher","award":["NTF21021"],"award-info":[{"award-number":["NTF21021"]}],"id":[{"id":"10.13039\/100009047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07051-8","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T09:48:44Z","timestamp":1756806524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outbreak dates of virus could be predicted by their protein sequence"],"prefix":"10.1186","volume":"23","author":[{"given":"Peijun","family":"Zuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longlong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaocheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Bakr M.","family":"Rabie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"issue":"3","key":"7051_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12519-019-00317-4","volume":"16","author":"C Sun","year":"2020","unstructured":"Sun C, Wang Q, Li WT, Wen DN, Chen CH, Yang X, et al. Molecular characteristics and antimicrobial susceptibility of Staphylococcus aureus among children with respiratory tract infections in southwest China. World J Pediatr. 2020;16(3):284\u201392. https:\/\/doi.org\/10.1007\/s12519-019-00317-4 (Epub 2019 Oct 16. PMID: 31620982).","journal-title":"World J Pediatr"},{"issue":"1","key":"7051_CR2","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bbrc.2017.11.126","volume":"495","author":"X Yao","year":"2018","unstructured":"Yao X, Gray S, Pham T, Delgardo M, Nguyen A, Do S, et al. Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin. Biochem Biophys Res Commun. 2018;495(1):1240\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"7051_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70191","volume":"7","author":"M Torabizadeh","year":"2024","unstructured":"Torabizadeh M, Aghaei M, Saki N, Vahid MA, Bitaraf S, Bandar B. The association of nasal and blood eosinophils with serum IgE level in allergic rhinitis and asthma: a case-control study. Health Sci Rep. 2024;7(11):e70191. https:\/\/doi.org\/10.1002\/hsr2.70191.","journal-title":"Health Sci Rep"},{"issue":"1","key":"7051_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01588-0","volume":"25","author":"A Raoufi","year":"2025","unstructured":"Raoufi A, Soleimani Samarkhazan H, Nouri S, Khaksari MN, Abbasi Sourki P, Sargazi Aval O, et al. Macrophages in graft-versus-host disease (GVHD): dual roles as therapeutic tools and targets. Clin Exp Med. 2025;25(1):73. https:\/\/doi.org\/10.1007\/s10238-025-01588-0.","journal-title":"Clin Exp Med"},{"issue":"2","key":"7051_CR5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.61186\/ijbc.16.2.84","volume":"16","author":"SA Aghapour","year":"2024","unstructured":"Aghapour SA, Torabizadeh M, Bahreiny SS, Saki N, Jalali Far MA, Yousefi-Avarvand A, et al. Investigating the dynamic interplay between cellular immunity and tumor cells in the fight against cancer: an updated comprehensive review. Iran J Blood Cancer. 2024;16(2):84\u2013101.","journal-title":"Iran J Blood Cancer"},{"issue":"10","key":"7051_CR6","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/17474086.2024.2391102","volume":"17","author":"Z Eftekhar","year":"2024","unstructured":"Eftekhar Z, Aghaei M, Saki N. DNA damage repair in megakaryopoiesis: molecular and clinical aspects. Expert Rev Hematol. 2024;17(10):705\u201312. https:\/\/doi.org\/10.1080\/17474086.2024.2391102. (39117495).","journal-title":"Expert Rev Hematol"},{"key":"7051_CR7","first-page":"234","volume":"9","author":"P Zuo","year":"2024","unstructured":"Zuo P, Zuo L, Li Z, Li L. Superantigens, antigen precision and their application in coronavirus. Diagnos Pathol Open. 2024;9:234.","journal-title":"Diagnos Pathol Open"},{"issue":"12","key":"7051_CR8","first-page":"1087","volume":"44","author":"SH Xu","year":"2010","unstructured":"Xu SH, Li YX, Li ST, Wu Q, Sun FQ, Huang F, et al. Epidemic condition and biological characteristics of non-O1\/non-O139 Vibrio cholerae in Haizhu District of Guangzhou. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44(12):1087\u201390 (Chinese PMID: 21215109).","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"issue":"10370","key":"7051_CR9","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0140-6736(22)02075-X","volume":"401","author":"O Mitj\u00e0","year":"2023","unstructured":"Mitj\u00e0 O, Ogoina D, Titanji BK, Galvan C, Muyembe JJ, Marks M, et al. Monkeypox Lancet. 2023;401(10370):60\u201374.","journal-title":"Monkeypox Lancet"},{"key":"7051_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102327","volume":"48","author":"I Ilic","year":"2022","unstructured":"Ilic I, Ilic M. Historical review: towards the 50th anniversary of the last major smallpox outbreak (Yugoslavia, 1972). Travel Med Infect Dis. 2022;48:102327. https:\/\/doi.org\/10.1016\/j.tmaid.2022.102327.","journal-title":"Travel Med Infect Dis"},{"key":"7051_CR11","unstructured":"Zhang D, Lu J (2021) Epidemiology of infectious diseases. epidemic practice workbook. Sun Yat-Sen-University Press, Available from: http:\/\/www.zsup.com.cn"},{"issue":"1","key":"7051_CR12","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01062-13","volume":"5","author":"M Cotten","year":"2014","unstructured":"Cotten M, Watson SJ, Zumla AI, Makhdoom HQ, Palser AL, Ong SH, et al. Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. MBio. 2014;5(1):e01062-13. https:\/\/doi.org\/10.1128\/mBio.01062-13.","journal-title":"MBio"},{"issue":"7798","key":"7051_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","volume":"579","author":"P Zhou","year":"2020","unstructured":"Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270\u20133.","journal-title":"Nature"},{"key":"7051_CR14","doi-asserted-by":"publisher","unstructured":"Peijun Z, Longlong Z, Zhihong L et al. (2024) Superantigens, Antigen Precision and Their Applications, 27 February 2024, PREPRINT (Version 1) available at Research Square [https:\/\/doi.org\/10.21203\/rs.3.rs-3989522\/v1]","DOI":"10.21203\/rs.3.rs-3989522\/v1"},{"issue":"4","key":"7051_CR15","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.cell.2020.06.043","volume":"182","author":"B Korber","year":"2020","unstructured":"Korber B, et al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 Virus. Cell. 2020;182(4):812-827 e193.","journal-title":"Cell"},{"issue":"12","key":"7051_CR16","doi-asserted-by":"publisher","first-page":"6551","DOI":"10.1002\/jmv.27210","volume":"93","author":"S Pascarella","year":"2021","unstructured":"Pascarella S, et al. SARS-CoV-2 B.1.617 Indian variants: are electrostatic potential changes responsible for a higher transmission rate? J Med Virol. 2021;93(12):6551\u20136.","journal-title":"J Med Virol"},{"key":"7051_CR17","unstructured":"Aleem A, Akbar Samad AB, Slenker AK (2022) Emerging variants of SARS-CoV-2 And novel therapeutics against coronavirus (COVID-19), in StatPearls. Treasure Island (FL)"},{"issue":"11","key":"7051_CR18","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/tmi.13821","volume":"27","author":"V Kipkorir","year":"2022","unstructured":"Kipkorir V, Dhali A, Srichawla B, Kutikuppala S, Cox M, Ochieng D, et al. The re-emerging monkeypox disease. Trop Med Int Health. 2022;27(11):961\u20139. https:\/\/doi.org\/10.1111\/tmi.13821.","journal-title":"Trop Med Int Health"},{"issue":"4","key":"7051_CR19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/infdis\/154.4.551","volume":"154","author":"Z Jezek","year":"1986","unstructured":"Jezek Z, Marennikova SS, Mutumbo M, Nakano JH, Paluku KM, Szczeniowski M. Human monkeypox: a study of 2,510 contacts of 214 patients. J Infect Dis. 1986;154(4):551\u20135. https:\/\/doi.org\/10.1093\/infdis\/154.4.551.","journal-title":"J Infect Dis"},{"issue":"10472","key":"7051_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0140-6736(24)02353-5","volume":"405","author":"CG Beiras","year":"2025","unstructured":"Beiras CG, Malembi E, Escrig-Sarreta R, Ahuka S, Mbala P, Mavoko HM, et al. Concurrent outbreaks of mpox in Africa-an update. Lancet. 2025;405(10472):86\u201396. https:\/\/doi.org\/10.1016\/S0140-6736(24)02353-5.","journal-title":"Lancet"},{"issue":"1\u20132","key":"7051_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00430-004-0219-0","volume":"194","author":"HF Rabenau","year":"2005","unstructured":"Rabenau HF, Cinatl J, Morgenstern B, Bauer G, Preiser W, Doerr HW. Stability and inactivation of SARS coronavirus. Med Microbiol Immunol. 2005;194(1\u20132):1\u20136. https:\/\/doi.org\/10.1007\/s00430-004-0219-0.","journal-title":"Med Microbiol Immunol"},{"key":"7051_CR22","doi-asserted-by":"crossref","unstructured":"Zuo, P et al. Antigen evolution from D614, to G614, to Delta, and to Omicron subtype of SARS-CoV-2. 2022; Available from: https:\/\/www.researchsquare.com\/article\/rs-1859710\/v1.","DOI":"10.21203\/rs.3.rs-1859710\/v1"},{"key":"7051_CR23","doi-asserted-by":"publisher","unstructured":"Zuo P, Zuo L, Li Z, Li L (2023) Virulence and infectivity were associated with different fragments in the Delta subtype of SARS-CoV-2 [Internet]. New COVID-19 Variants [Working Title]. IntechOpen. 2023; Available from: https:\/\/doi.org\/10.5772\/intechopen.1002856","DOI":"10.5772\/intechopen.1002856"},{"issue":"3","key":"7051_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s12223-010-0036-3","volume":"55","author":"Q Meng","year":"2010","unstructured":"Meng Q, et al. Spiralin-like protein SLP31 from Spiroplasma eriocheiris as a potential antigen for immunodiagnostics of tremor disease in Chinese mitten crab Eriocheir sinensis. Folia Microbiol (Praha). 2010;55(3):245\u201350.","journal-title":"Folia Microbiol (Praha)"},{"issue":"6","key":"7051_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204006","volume":"10","author":"D Liu","year":"2023","unstructured":"Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, et al. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumor growth. Adv Sci (Weinh). 2023;10(6):e2204006. https:\/\/doi.org\/10.1002\/advs.202204006.","journal-title":"Adv Sci (Weinh)"},{"issue":"10","key":"7051_CR26","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/imcb.12168","volume":"96","author":"AA Badawy","year":"2018","unstructured":"Badawy AA. Targeting tryptophan availability to tumors: the answer to immune escape? Immunol Cell Biol. 2018;96(10):1026\u201334. https:\/\/doi.org\/10.1111\/imcb.12168. (2018 Jun 10. PMID: 29888434).","journal-title":"Immunol Cell Biol"},{"issue":"9","key":"7051_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70083","volume":"7","author":"E Torfi","year":"2024","unstructured":"Torfi E, Bahreiny SS, Saki N, Khademi R, Sarbazjoda E, Nezhad IA, et al. Evaluation of Pro-BNP biomarker in heart failure patients and its relationship with complete blood count parameters: a case-control study. Health Sci Rep. 2024;7(9):e70083. https:\/\/doi.org\/10.1002\/hsr2.70083.","journal-title":"Health Sci Rep"},{"issue":"6","key":"7051_CR28","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3201\/eid2306.170047.PMID:28518032;PMCID:PMC5443453","volume":"23","author":"L Nyakarahuka","year":"2017","unstructured":"Nyakarahuka L, Ojwang J, Tumusiime A, Balinandi S, Whitmer S, Kyazze S, et al. Isolated case of Marburg virus disease, Kampala, Uganda, 2014. Emerg Infect Dis. 2017;23(6):1001\u20134. https:\/\/doi.org\/10.3201\/eid2306.170047.PMID:28518032;PMCID:PMC5443453.","journal-title":"Emerg Infect Dis"},{"key":"7051_CR29","doi-asserted-by":"publisher","unstructured":"Peijun Z, Liping L (2022) Antigen evolution from D614, to G614, and to Delta subtype of SARS-CoV-2, 04 January 2022; Preprint (Version 1) available at Research Square https:\/\/doi.org\/10.21203\/rs.3.rs-1218337\/v1","DOI":"10.21203\/rs.3.rs-1218337\/v1"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07051-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07051-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07051-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:25:43Z","timestamp":1757478343000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07051-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7051"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07051-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"type":"electronic","value":"1479-5876"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"15 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is not a traditional epidemiological study, but to find the relation between protein molecular and the epidemic disease caused by the protein mutation. It did not contain any samples from human and animals. A research ethics approval is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"980"}}