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The objective of this study was to evaluate the\n                      <jats:italic>TRIM8<\/jats:italic>\n                      gene and its associated non-coding RNAs (\n                      <jats:italic>lnc-SSBP2-1:1<\/jats:italic>\n                      and\n                      <jats:italic>hsa-miR-126-5p<\/jats:italic>\n                      ) as potential non-invasive biomarkers for LN activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of\n                      <jats:italic>TRIM8lnc-SSBP2-1:1<\/jats:italic>\n                      and\n                      <jats:italic>hsa-miR-126-5p<\/jats:italic>\n                      were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>TRIM8<\/jats:italic>\n                      mRNA and\n                      <jats:italic>lnc-SSBP2-1:1<\/jats:italic>\n                      lncRNA levels were notably upregulated in active LN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while\n                      <jats:italic>hsa-miR-126-5p<\/jats:italic>\n                      was reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). SLEDAI-2K scores correlated positively with\n                      <jats:italic>TRIM8<\/jats:italic>\n                      mRNA and\n                      <jats:italic>lnc-SSBP2-1:1<\/jats:italic>\n                      , and negatively with\n                      <jats:italic>hsa-miR-126-5p<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study highlights\n                      <jats:italic>TRIM8<\/jats:italic>\n                      -associated ncRNA regulatory network as promising biomarkers in LN activ\u03c9ity, with potential clinical impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-025-07137-3","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:52:06Z","timestamp":1762354326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-556X","authenticated-orcid":false,"given":"Mostafa Abdelnasier Abd","family":"Elgawad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6487-3301","authenticated-orcid":false,"given":"Howayda Abdelhamid El","family":"Shinnawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-3244","authenticated-orcid":false,"given":"Sanaa","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8537-876X","authenticated-orcid":false,"given":"Nouran Abdelfattah Sayed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-3932","authenticated-orcid":false,"given":"Maha Abdelmoneim","family":"Behairy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-0303","authenticated-orcid":false,"given":"Cherry Reda","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-0887","authenticated-orcid":false,"given":"Marwa Mostafa","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"issue":"19","key":"7137_CR1","doi-asserted-by":"publisher","first-page":"10737","DOI":"10.3390\/IJMS221910737","volume":"22","author":"BYF So","year":"2021","unstructured":"So BYF, Yap DYH, Chan TM. 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Ethical approval was granted by the Ain Shams university research ethics committee (FWA. 000017585). The study was conducted in accordance with the Declaration of Helsinki and followed the ethical standards set by the United States Office for Human Research Protections and the United States Code of Federal Regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No financial or non-financial benefits have been received or will be obtained from any party related directly or indirectly to the subject of this article. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1229"}}