{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:27:34Z","timestamp":1776954454187,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271710"],"award-info":[{"award-number":["82271710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071669"],"award-info":[{"award-number":["82071669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201874, 81960283"],"award-info":[{"award-number":["82201874, 81960283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010399, 2023A1515030222, 2024A1515140102"],"award-info":[{"award-number":["2022A1515010399, 2023A1515030222, 2024A1515140102"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011730"],"award-info":[{"award-number":["2022A1515011730"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Guangzhou","award":["SL2023A04J01257, 202102020282"],"award-info":[{"award-number":["SL2023A04J01257, 202102020282"]}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["822MS175"],"award-info":[{"award-number":["822MS175"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Open Project of Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research","award":["SZLAB202303"],"award-info":[{"award-number":["SZLAB202303"]}]},{"name":"Specific Research Fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07159-x","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:16:27Z","timestamp":1763464587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unraveling the impact of hsa-miR-518c-5p on placental health: mechanistic insights into preeclampsia pathogenesis"],"prefix":"10.1186","volume":"23","author":[{"given":"Lu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuling","family":"Jie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-3836","authenticated-orcid":false,"given":"Xiaojing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"7159_CR1","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","volume":"76","author":"CW Ives","year":"2020","unstructured":"Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol. 2020;76:1690\u2013702.","journal-title":"J Am Coll Cardiol"},{"key":"7159_CR2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002639RRR","volume":"35","author":"L Huang","year":"2021","unstructured":"Huang L, Ma Y, Chen L, Chang J, Zhong M, Wang Z, et al. Maternal RND3\/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARgamma-UCP2 cascade. FASEB J. 2021;35:e21555.","journal-title":"FASEB J"},{"key":"7159_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.664766","author":"YL Feng","year":"2021","unstructured":"Feng YL, Chen X, Wang HQ, Chen XP, Lan ZX, Li P, et al. Collagen i induces preeclampsia-like symptoms by suppressing proliferation and invasion of trophoblasts. Front Endocrinol. 2021. https:\/\/doi.org\/10.3389\/fendo.2021.664766.","journal-title":"Front Endocrinol"},{"key":"7159_CR4","doi-asserted-by":"publisher","first-page":"S928","DOI":"10.1016\/j.ajog.2020.11.005","volume":"226","author":"I Aye","year":"2022","unstructured":"Aye I, Aiken CE, Charnock-Jones DS, Smith GCS. Placental energy metabolism in health and disease-significance of development and implications for preeclampsia. Am J Obstet Gynecol. 2022;226:S928\u201344.","journal-title":"Am J Obstet Gynecol"},{"key":"7159_CR5","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","volume":"124","author":"S Rana","year":"2019","unstructured":"Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124:1094\u2013112.","journal-title":"Circ Res"},{"key":"7159_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213836","author":"I Jaszczuk","year":"2022","unstructured":"Jaszczuk I, Winkler I, Koczkodaj D, Skrzypczak M, Filip A. The role of cluster C19MC in pre-eclampsia development. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232213836.","journal-title":"Int J Mol Sci"},{"key":"7159_CR7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.2174\/2211536610666211022144655","volume":"10","author":"AYG Fonseca","year":"2021","unstructured":"Fonseca AYG, Santos JG, Aristizabal-Pachon AF. An overview of C19MC cluster subgroup 3 and cancer. Microrna. 2021;10:154\u201363.","journal-title":"Microrna"},{"issue":"1","key":"7159_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30775-w","volume":"13","author":"N Kobayashi","year":"2022","unstructured":"Kobayashi N, Okae H, Hiura H, Kubota N, Kobayashi EH, Shibata S, et al. The microrna cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells. Nat Commun. 2022;13(1):3071.","journal-title":"Nat Commun"},{"key":"7159_CR9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/molehr\/gas013","volume":"18","author":"RB Donker","year":"2012","unstructured":"Donker RB, Mouillet JF, Chu T, Hubel CA, Stolz DB, Morelli AE, et al. The expression profile of C19MC micrornas in primary human trophoblast cells and exosomes. Mol Hum Reprod. 2012;18:417\u201324.","journal-title":"Mol Hum Reprod"},{"key":"7159_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115936","volume":"9","author":"M Kinouchi","year":"2014","unstructured":"Kinouchi M, Uchida D, Kuribayashi N, Tamatani T, Nagai H, Miyamoto Y. Involvement of miR-518c-5p to growth and metastasis in oral cancer. PLoS ONE. 2014;9:e115936.","journal-title":"PLoS ONE"},{"key":"7159_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.7555\/JBR.37.20230097","volume":"38","author":"J Zhou","year":"2023","unstructured":"Zhou J, Xu Y, Wang L, Cong Y, Huang K, Pan X, et al. Lncrna IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47. J Biomed Res. 2023;38:51\u201365.","journal-title":"J Biomed Res"},{"key":"7159_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00009","volume":"11","author":"JH He","year":"2020","unstructured":"He JH, Han ZP, Luo JG, Jiang JW, Zhou JB, Chen WM, et al. Hsa_Circ_0007843 acts as a mIR-518c-5p sponge to regulate the migration and invasion of colon cancer SW480 cells. Front Genet. 2020;11:9.","journal-title":"Front Genet"},{"issue":"20","key":"7159_CR13","doi-asserted-by":"publisher","first-page":"7624","DOI":"10.3390\/ijms21207624","volume":"21","author":"I Kaszak","year":"2020","unstructured":"Kaszak I, Witkowska-Pilaszewicz O, Niewiadomska Z, Dworecka-Kaszak B, Ngosa Toka F, Jurka P. Role of Cadherins in cancer: a review. Int J Mol Sci. 2020;21(20):7624.","journal-title":"Int J Mol Sci"},{"key":"7159_CR14","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/10409238.2017.1295920","volume":"52","author":"M Dunach","year":"2017","unstructured":"Dunach M, Del Valle-Perez B. Garcia de Herreros A: p120-catenin in canonical Wnt signaling. Crit Rev Biochem Mol Biol. 2017;52:327\u201339.","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"3","key":"7159_CR15","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3390\/jcm11030668","volume":"11","author":"M Peksa","year":"2022","unstructured":"Peksa M, Kamieniecki A, Gabrych A, Lew-Tusk A, Preis K, Swiatkowska-Freund M. Loss of E-Cadherin staining continuity in the trophoblastic basal membrane correlates with increased resistance in uterine arteries and proteinuria in patients with pregnancy-induced hypertension. J Clin Med. 2022;11(3):668.","journal-title":"J Clin Med"},{"key":"7159_CR16","doi-asserted-by":"crossref","unstructured":"Gestational Hypertension and Preeclampsia: ACOG practice bulletin summary, Number 222. Obstet Gynecol 2020, 135:1492-1495","DOI":"10.1097\/AOG.0000000000003892"},{"key":"7159_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41586-018-0753-3","volume":"564","author":"MY Turco","year":"2018","unstructured":"Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 2018;564:263\u20137.","journal-title":"Nature"},{"issue":"810\u2013825","key":"7159_CR18","volume":"29","author":"RM Karvas","year":"2022","unstructured":"Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, et al. Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens. Cell Stem Cell. 2022;29(810\u2013825):e818.","journal-title":"Cell Stem Cell"},{"key":"7159_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","volume":"21","author":"M Hemberger","year":"2020","unstructured":"Hemberger M, Hanna CW, Dean W. Mechanisms of early placental development in mouse and humans. Nat Rev Genet. 2020;21:27\u201343.","journal-title":"Nat Rev Genet"},{"key":"7159_CR20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.placenta.2022.01.003","volume":"118","author":"C Cao","year":"2022","unstructured":"Cao C, Dai Y, Wang Z, Zhao G, Duan H, Zhu X, et al. The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia. Placenta. 2022;118:55\u201365.","journal-title":"Placenta"},{"key":"7159_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/19336918.2015.1106669","volume":"10","author":"PK Lala","year":"2016","unstructured":"Lala PK, Nandi P. Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: the role of decorin. Cell Adhes Migr. 2016;10:111\u201325.","journal-title":"Cell Adhes Migr"},{"key":"7159_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115266","volume":"206","author":"H Qu","year":"2022","unstructured":"Qu H, Khalil RA. Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia. Biochem Pharmacol. 2022;206:115266.","journal-title":"Biochem Pharmacol"},{"issue":"23","key":"7159_CR23","doi-asserted-by":"publisher","first-page":"7051","DOI":"10.3390\/jcm11237051","volume":"11","author":"A Kondracka","year":"2022","unstructured":"Kondracka A, Jaszczuk I, Koczkodaj D, Kondracki B, Fraszczak K, Oniszczuk A, et al. Analysis of circulating C19MC MicroRNA as an early marker of hypertension and preeclampsia in pregnant patients: a systematic review. J Clin Med. 2022;11(23):7051.","journal-title":"J Clin Med"},{"key":"7159_CR24","doi-asserted-by":"publisher","first-page":"12048","DOI":"10.1073\/pnas.1304718110","volume":"110","author":"E Delorme-Axford","year":"2013","unstructured":"Delorme-Axford E, Donker RB, Mouillet JF, Chu T, Bayer A, Ouyang Y, et al. Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci U S A. 2013;110:12048\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7159_CR25","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.121616","volume":"91","author":"S Kambe","year":"2014","unstructured":"Kambe S, Yoshitake H, Yuge K, Ishida Y, Ali MM, Takizawa T, et al. Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. Biol Reprod. 2014;91:129.","journal-title":"Biol Reprod"},{"key":"7159_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103458","author":"W Chaiwangyen","year":"2020","unstructured":"Chaiwangyen W, Murrieta-Coxca JM, Favaro RR, Photini SM, Gutierrez-Samudio RN, Schleussner E, et al. MiR-519d-3p in trophoblastic cells: effects, targets and transfer to allogeneic immune cells via extracellular vesicles. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21103458.","journal-title":"Int J Mol Sci"},{"key":"7159_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00100","volume":"9","author":"M Liu","year":"2018","unstructured":"Liu M, Wang Y, Lu H, Wang H, Shi X, Shao X, et al. MiR-518b enhances human trophoblast cell proliferation through targeting Rap1b and activating Ras-MAPK signal. Front Endocrinol (Lausanne). 2018;9:100.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7159_CR28","doi-asserted-by":"publisher","first-page":"E7069","DOI":"10.1073\/pnas.1607849113","volume":"113","author":"M Zhang","year":"2016","unstructured":"Zhang M, Muralimanoharan S, Wortman AC, Mendelson CR. Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia. Proc Natl Acad Sci U S A. 2016;113:E7069\u201376.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7159_CR29","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13046-019-1108-0","volume":"38","author":"DM Chai","year":"2019","unstructured":"Chai DM, Qin YZ, Wu SW, Ma L, Tan YY, Yong X, et al. WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells. J Exp Clin Cancer Res. 2019;38:102.","journal-title":"J Exp Clin Cancer Res"},{"key":"7159_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102971","volume":"299","author":"H Zhang","year":"2023","unstructured":"Zhang H, Song W, Ma X, Yu M, Chen L, Tao Y. Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia. J Biol Chem. 2023;299:102971.","journal-title":"J Biol Chem"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07159-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07159-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07159-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:05:36Z","timestamp":1763507136000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07159-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7159"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07159-x","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human placental tissues were obtained with written informed consent and approval from the Ethics Committees of Southern Hospital, Southern Medical University (Ethic Approval No. NFEC-2020-155), and the First Affiliated Hospital of Hainan Medical University (Ethic Approval No. 2024-KYL-160).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1305"}}