{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:41:10Z","timestamp":1768434070953,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2020M681739"],"award-info":[{"award-number":["2020M681739"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2021046, LKM2022048, LSD2022014, LKM2024032"],"award-info":[{"award-number":["Z2021046, LKM2022048, LSD2022014, LKM2024032"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["XZSYSKF2020004"],"award-info":[{"award-number":["XZSYSKF2020004"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018636","name":"Xuzhou Science and Technology Program","doi-asserted-by":"publisher","award":["KC22273, KC22168"],"award-info":[{"award-number":["KC22273, KC22168"]}],"id":[{"id":"10.13039\/501100018636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018636","name":"Xuzhou Science and Technology Program","doi-asserted-by":"publisher","award":["XWKYHT20240010, 20240039"],"award-info":[{"award-number":["XWKYHT20240010, 20240039"]}],"id":[{"id":"10.13039\/501100018636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016802","name":"Natural Science Foundation of Changzhou Municipality","doi-asserted-by":"publisher","award":["ZD202340"],"award-info":[{"award-number":["ZD202340"]}],"id":[{"id":"10.13039\/100016802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017951","name":"Health Commission of Qinghai Province","doi-asserted-by":"publisher","award":["2023-wjzdx-106"],"award-info":[{"award-number":["2023-wjzdx-106"]}],"id":[{"id":"10.13039\/100017951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07212-9","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:28:18Z","timestamp":1760700498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pyrroloquinoline quinone targets senescent osteoclasts and reduces spinal pain and endplate degeneration in a lumbar spine instability mouse model"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-1313","authenticated-orcid":false,"given":"Qinghe","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Heng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingchen","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangwei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinuo","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiru","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanshuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiyuan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangshuang","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanji","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyun","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengsheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangfei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"7212_CR1","unstructured":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789\u20131858."},{"issue":"6","key":"7212_CR2","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1002\/art.34347","volume":"64","author":"D Hoy","year":"2012","unstructured":"Hoy D, et al. A systematic review of the global prevalence of low back pain. Arthritis Rheum. 2012;64(6):2028\u201337.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"7212_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ncl.2007.01.004","volume":"25","author":"DI Rubin","year":"2007","unstructured":"Rubin DI. Epidemiology and risk factors for spine pain. Neurol Clin. 2007;25(2):353\u201371.","journal-title":"Neurol Clin"},{"issue":"6","key":"7212_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.21037\/atm.2020.02.175","volume":"8","author":"A Wu","year":"2020","unstructured":"Wu A, et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the global burden of disease study 2017. Ann Transl Med. 2020;8(6):299.","journal-title":"Ann Transl Med"},{"issue":"1","key":"7212_CR5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1302\/0301-620X.79B1.0790147","volume":"79","author":"MF Brown","year":"1997","unstructured":"Brown MF, et al. Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Joint Surg Br. 1997;79(1):147\u201353.","journal-title":"J Bone Joint Surg Br"},{"issue":"7","key":"7212_CR6","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/01.brs.0000259059.90430.c2","volume":"32","author":"H Schmidt","year":"2007","unstructured":"Schmidt H, et al. Intradiscal pressure, shear strain, and fiber strain in the intervertebral disc under combined loading. Spine (Phila Pa 1976). 2007;32(7):748\u201355.","journal-title":"Spine (Phila Pa 1976)"},{"key":"7212_CR7","doi-asserted-by":"publisher","first-page":"27093","DOI":"10.1038\/srep27093","volume":"6","author":"Q Bian","year":"2016","unstructured":"Bian Q, et al. Excessive activation of TGF\u03b2 by spinal instability causes vertebral endplate sclerosis. Sci Rep. 2016;6:27093.","journal-title":"Sci Rep"},{"issue":"9","key":"7212_CR8","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1007\/s00586-016-4715-x","volume":"25","author":"K Luoma","year":"2016","unstructured":"Luoma K, et al. Chronic low back pain in relation to modic changes, bony endplate lesions, and disc degeneration in a prospective MRI study. Eur Spine J. 2016;25(9):2873\u201381.","journal-title":"Eur Spine J"},{"key":"7212_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jot.2019.10.005","volume":"24","author":"Q Liu","year":"2020","unstructured":"Liu Q, et al. Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats. J Orthop Translat. 2020;24:209\u201317.","journal-title":"J Orthop Translat"},{"issue":"3","key":"7212_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.spinee.2013.06.075","volume":"14","author":"AJ Fields","year":"2014","unstructured":"Fields AJ, Liebenberg EC, Lotz JC. Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc. Spine J. 2014;14(3):513\u201321.","journal-title":"Spine J"},{"issue":"1","key":"7212_CR11","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1038\/s41467-019-13476-9","volume":"10","author":"S Ni","year":"2019","unstructured":"Ni S, et al. Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. Nat Commun. 2019;10(1):5643.","journal-title":"Nat Commun"},{"key":"7212_CR12","doi-asserted-by":"crossref","unstructured":"Pan D, et al. Senescence of endplate osteoclasts induces sensory innervation and spinal pain. Elife. 2024; 12.","DOI":"10.7554\/eLife.92889.3"},{"issue":"8","key":"7212_CR13","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","volume":"28","author":"S Chaib","year":"2022","unstructured":"Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28(8):1556\u201368.","journal-title":"Nat Med"},{"issue":"2","key":"7212_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1177\/1074248406288757","volume":"11","author":"BQ Zhu","year":"2006","unstructured":"Zhu BQ, et al. Comparison of pyrroloquinoline Quinone and\/or Metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia\/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006;11(2):119\u201328.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"7212_CR15","doi-asserted-by":"crossref","unstructured":"Cores \u00c1, et al. Quinones as neuroprotective agents. Antioxidants (Basel). 2023;12(7).","DOI":"10.3390\/antiox12071464"},{"issue":"5","key":"7212_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41401-020-0487-2","volume":"42","author":"Q Cheng","year":"2021","unstructured":"Cheng Q, et al. Pyrroloquinoline Quinone promotes mitochondrial biogenesis in rotenone-induced parkinson\u2019s disease model via AMPK activation. Acta Pharmacol Sin. 2021;42(5):665\u201378.","journal-title":"Acta Pharmacol Sin"},{"key":"7212_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1750-1326-5-20","volume":"5","author":"J Kim","year":"2010","unstructured":"Kim J, et al. The inhibitory effect of pyrroloquinoline Quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein. Mol Neurodegener. 2010;5:20.","journal-title":"Mol Neurodegener"},{"key":"7212_CR18","doi-asserted-by":"publisher","first-page":"1200025","DOI":"10.3389\/fmolb.2023.1200025","volume":"10","author":"NS Mohamad Ishak","year":"2023","unstructured":"Mohamad Ishak NS, Ikemoto K. Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression. Front Mol Biosci. 2023;10:1200025.","journal-title":"Front Mol Biosci"},{"issue":"3","key":"7212_CR19","first-page":"1614","volume":"40","author":"R Wu","year":"2018","unstructured":"Wu R, et al. Apoptotic effect of pyrroloquinoline Quinone on chondrosarcoma cells through activation of the mitochondrial caspase\u2013dependent and caspase\u2013independent pathways. Oncol Rep. 2018;40(3):1614\u201320.","journal-title":"Oncol Rep"},{"issue":"1","key":"7212_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7150\/ijbs.25783","volume":"15","author":"Q Geng","year":"2019","unstructured":"Geng Q, et al. Pyrroloquinoline Quinone prevents Estrogen Deficiency-Induced osteoporosis by inhibiting oxidative stress and osteocyte senescence. Int J Biol Sci. 2019;15(1):58\u201368.","journal-title":"Int J Biol Sci"},{"issue":"22","key":"7212_CR21","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1097\/00007632-200111150-00004","volume":"26","author":"K Ariga","year":"2001","unstructured":"Ariga K, et al. The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine (Phila Pa 1976). 2001;26(22):2414\u201320.","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"7212_CR22","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1038\/s41467-024-47317-1","volume":"15","author":"Y Fan","year":"2024","unstructured":"Fan Y, et al. Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice. Nat Commun. 2024;15(1):2939.","journal-title":"Nat Commun"},{"issue":"7","key":"7212_CR23","first-page":"4232","volume":"11","author":"Q Geng","year":"2019","unstructured":"Geng Q, et al. A soluble bone morphogenetic protein type 1A receptor fusion protein treatment prevents glucocorticoid-Induced bone loss in mice. Am J Transl Res. 2019;11(7):4232\u201347.","journal-title":"Am J Transl Res"},{"issue":"3","key":"7212_CR24","first-page":"743","volume":"12","author":"S Wang","year":"2020","unstructured":"Wang S, et al. Treatment with soluble bone morphogenetic protein type 1A receptor fusion protein alleviates irradiation-induced bone loss in mice through increased bone formation and reduced bone resorption. Am J Transl Res. 2020;12(3):743\u201357.","journal-title":"Am J Transl Res"},{"issue":"3","key":"7212_CR25","doi-asserted-by":"publisher","first-page":"e21414","DOI":"10.1096\/fj.202002524R","volume":"35","author":"X Lv","year":"2021","unstructured":"Lv X, et al. Resveratrol-enhanced SIRT1-mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors. Faseb J. 2021;35(3):e21414.","journal-title":"Faseb J"},{"issue":"1","key":"7212_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/01.brs.0000148152.04401.20","volume":"30","author":"K Masuda","year":"2005","unstructured":"Masuda K, et al. A novel rabbit model of mild, reproducible disc degeneration by an Anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976). 2005;30(1):5\u201314.","journal-title":"Spine (Phila Pa 1976)"},{"issue":"24","key":"7212_CR27","doi-asserted-by":"publisher","first-page":"e2300330","DOI":"10.1002\/mnfr.202300330","volume":"67","author":"S Wang","year":"2023","unstructured":"Wang S, et al. Lycopene improves bone quality in SAMP6 mice by inhibiting oxidative Stress, cellular Senescence, and the SASP. Mol Nutr Food Res. 2023;67(24):e2300330.","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"7212_CR28","doi-asserted-by":"publisher","first-page":"30417","DOI":"10.1038\/s41598-024-82262-5","volume":"14","author":"S Wang","year":"2024","unstructured":"Wang S, et al. Senolytic cocktail dasatinib and Quercetin attenuates chronic high altitude hypoxia associated bone loss in mice. Sci Rep. 2024;14(1):30417.","journal-title":"Sci Rep"},{"issue":"22","key":"7212_CR29","doi-asserted-by":"publisher","first-page":"11770","DOI":"10.1039\/D2FO01673G","volume":"13","author":"Q Geng","year":"2022","unstructured":"Geng Q, et al. Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP. Food Funct. 2022;13(22):11770\u20139.","journal-title":"Food Funct"},{"issue":"10289","key":"7212_CR30","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","volume":"397","author":"MA Fitzcharles","year":"2021","unstructured":"Fitzcharles MA, et al. Nociplastic pain: towards an Understanding of prevalent pain conditions. Lancet. 2021;397(10289):2098\u2013110.","journal-title":"Lancet"},{"issue":"4","key":"7212_CR31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2017.05.012","volume":"94","author":"RA Hand","year":"2017","unstructured":"Hand RA, Kolodkin AL. Netrin-Mediated axon guidance to the CNS midline revisited. Neuron. 2017;94(4):691\u20133.","journal-title":"Neuron"},{"issue":"3","key":"7212_CR32","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1172\/JCI121561","volume":"129","author":"S Zhu","year":"2019","unstructured":"Zhu S, et al. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019;129(3):1076\u201393.","journal-title":"J Clin Invest"},{"issue":"6887","key":"7212_CR33","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature748","volume":"417","author":"C Forcet","year":"2002","unstructured":"Forcet C, et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature. 2002;417(6887):443\u20137.","journal-title":"Nature"},{"issue":"7492","key":"7212_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature13145","volume":"507","author":"AP Kusumbe","year":"2014","unstructured":"Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014;507(7492):323\u20138.","journal-title":"Nature"},{"issue":"8","key":"7212_CR35","doi-asserted-by":"publisher","first-page":"Itc113","DOI":"10.7326\/AITC202108170","volume":"174","author":"R Chou","year":"2021","unstructured":"Chou R. Low back pain. Ann Intern Med. 2021;174(8):Itc113\u201328.","journal-title":"Ann Intern Med"},{"issue":"9","key":"7212_CR36","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1038\/s41591-024-03096-2","volume":"30","author":"JN Farr","year":"2024","unstructured":"Farr JN, et al. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nat Med. 2024;30(9):2605\u201312.","journal-title":"Nat Med"},{"key":"7212_CR37","doi-asserted-by":"crossref","unstructured":"Zhu Y, et al. Past and future directions for research on cellular senescence. Cold Spring Harb Perspect Med. 2024;14(2).","DOI":"10.1101\/cshperspect.a041205"},{"issue":"10","key":"7212_CR38","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","volume":"18","author":"W Huang","year":"2022","unstructured":"Huang W, et al. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022;18(10):611\u201327.","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"7212_CR39","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1007\/s10753-024-02014-5","volume":"47","author":"S Guo","year":"2024","unstructured":"Guo S, et al. ROS-Induced gingival fibroblast senescence: implications in exacerbating inflammatory responses in periodontal disease. Inflammation. 2024;47(6):1918\u201335.","journal-title":"Inflammation"},{"issue":"1","key":"7212_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","volume":"17","author":"PR Coryell","year":"2021","unstructured":"Coryell PR, Diekman BO, Loeser RF. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat Rev Rheumatol. 2021;17(1):47\u201357.","journal-title":"Nat Rev Rheumatol"},{"key":"7212_CR41","doi-asserted-by":"publisher","first-page":"101915","DOI":"10.1016\/j.redox.2021.101915","volume":"41","author":"Y Guo","year":"2021","unstructured":"Guo Y, et al. Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis. Redox Biol. 2021;41:101915.","journal-title":"Redox Biol"},{"issue":"1","key":"7212_CR42","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1038\/s41467-017-01509-0","volume":"8","author":"C Li","year":"2017","unstructured":"Li C, et al. Programmed cell senescence in skeleton during late puberty. Nat Commun. 2017;8(1):1312.","journal-title":"Nat Commun"},{"issue":"10","key":"7212_CR43","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1016\/j.ymthe.2022.05.021","volume":"30","author":"J Wu","year":"2022","unstructured":"Wu J, et al. Self-amplifying loop of NF-\u03baB and Periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration. Mol Ther. 2022;30(10):3241\u201356.","journal-title":"Mol Ther"},{"issue":"1","key":"7212_CR44","doi-asserted-by":"publisher","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","volume":"12","author":"EJ Novais","year":"2021","unstructured":"Novais EJ, et al. Long-term treatment with senolytic drugs dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12(1):5213.","journal-title":"Nat Commun"},{"issue":"Suppl 2","key":"7212_CR45","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1007\/s00586-003-0593-0","volume":"12","author":"M Benoist","year":"2003","unstructured":"Benoist M. Natural history of the aging spine. Eur Spine J. 2003;12(Suppl 2):S86\u20139.","journal-title":"Eur Spine J"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07212-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07212-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07212-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:05:59Z","timestamp":1760702759000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07212-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7212"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07212-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"4 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the Institutional Animal Care and Use Committee of Pizhou Hospital (Ethics No. 2024-01-13).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1119"}}