{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:16:08Z","timestamp":1770275768672,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2021ZH0015"],"award-info":[{"award-number":["WJ2021ZH0015"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371079"],"award-info":[{"award-number":["82371079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100823"],"award-info":[{"award-number":["82100823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501021"],"award-info":[{"award-number":["82501021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFB271"],"award-info":[{"award-number":["2025AFB271"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07214-7","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:36:37Z","timestamp":1763462197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kynurenine-mediated redox regulation provides neuroprotection in central retinal artery occlusion"],"prefix":"10.1186","volume":"23","author":[{"given":"Linwei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuedang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anhuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-8689","authenticated-orcid":false,"given":"Xuan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"issue":"4","key":"7214_CR1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.18502\/jovr.v19i4.16559","volume":"19","author":"HJ Yu","year":"2024","unstructured":"Yu HJ, Choi S, Guiseppi R, Banaee T. Retinal artery occlusion: a review of current management practices. J Ophthalmic Vis Res. 2024;19(4):488\u2013507.","journal-title":"J Ophthalmic Vis Res"},{"issue":"1","key":"7214_CR2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s12967-024-05260-1","volume":"22","author":"J Wu","year":"2024","unstructured":"Wu J, Zhang D, Liu H, Li J, Li T, Wu J, et al. Neuroprotective effects of apigenin on retinal ganglion cells in ischemia\/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models. J Transl Med. 2024;22(1):447.","journal-title":"J Transl Med"},{"key":"7214_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/EB.S454977","volume":"16","author":"Y Yao","year":"2024","unstructured":"Yao Y, Song Q, Zhang J, Wen Y, Dou X. Retina-Brain homology: the correlation between ophthalmic or retinal artery occlusion and ischemic stroke. Eye Brain. 2024;16:25\u201338.","journal-title":"Eye Brain"},{"key":"7214_CR4","doi-asserted-by":"crossref","unstructured":"Roskal-Walek J, Ruzik A, Kubis N, Teper M, Wesolowski M, Wujec Z et al. Therapeutic strategies for retinal artery occlusion-A literature review. J Clin Med 2024;13(22).","DOI":"10.3390\/jcm13226813"},{"issue":"2","key":"7214_CR5","doi-asserted-by":"publisher","first-page":"e6081","DOI":"10.1002\/bmc.6081","volume":"39","author":"Z Ying","year":"2025","unstructured":"Ying Z, Pu J, Hu Y, Qian J, Luo S, Ni F, et al. Multimodal metabolomics analysis reveals that classic Decoction mitigates myocardial Ischemia-Induced damage by modulating energy and Branched-Chain amino acid metabolism. Biomed Chromatogr. 2025;39(2):e6081.","journal-title":"Biomed Chromatogr"},{"key":"7214_CR6","doi-asserted-by":"crossref","unstructured":"Yue Z, Zhang Y, Zhang W, Zheng N, Wen J, Ren L, et al. Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway. J Adv Res. 2024.","DOI":"10.1016\/j.jare.2024.10.037"},{"issue":"2","key":"7214_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41419-023-05616-3","volume":"14","author":"Y Yang","year":"2023","unstructured":"Yang Y, Wang N, Xu L, Liu Y, Huang L, Gu M, et al. Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia\/reperfusion injury. Cell Death Dis. 2023;14(2):92.","journal-title":"Cell Death Dis"},{"issue":"8","key":"7214_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/tvst.13.8.8","volume":"13","author":"W Mu","year":"2024","unstructured":"Mu W, Han X, Tong M, Ben S, Yao M, Zhao Y, et al. Identification of the metabolic signature of aging retina. Transl Vis Sci Technol. 2024;13(8):8.","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"7214_CR9","doi-asserted-by":"publisher","first-page":"e70703","DOI":"10.1002\/cam4.70703","volume":"14","author":"Z Lu","year":"2025","unstructured":"Lu Z, Zhang C, Zhang J, Su W, Wang G, Wang Z. The kynurenine pathway and Indole pathway in tryptophan metabolism influence tumor progression. Cancer Med. 2025;14(6):e70703.","journal-title":"Cancer Med"},{"issue":"1","key":"7214_CR10","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1038\/s41467-022-31126-5","volume":"13","author":"T Huang","year":"2022","unstructured":"Huang T, Song J, Gao J, Cheng J, Xie H, Zhang L, et al. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR\/STAT3\/IL-6 signaling. Nat Commun. 2022;13(1):3489.","journal-title":"Nat Commun"},{"issue":"7","key":"7214_CR11","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1136\/gutjnl-2022-327337","volume":"72","author":"C Michaudel","year":"2023","unstructured":"Michaudel C, Danne C, Agus A, Magniez A, Aucouturier A, Spatz M, et al. Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases. Gut. 2023;72(7):1296\u2013307.","journal-title":"Gut"},{"key":"7214_CR12","doi-asserted-by":"crossref","unstructured":"Wang Y, Li Y, Feng J, Wang C, Wan Y, Lv B et al. Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion. Elife. 2024;13.","DOI":"10.7554\/eLife.98949"},{"issue":"41","key":"7214_CR13","doi-asserted-by":"publisher","first-page":"e2407043","DOI":"10.1002\/advs.202407043","volume":"11","author":"X Zhou","year":"2024","unstructured":"Zhou X, Rong R, Liang G, Wu Y, Xu C, Xiao H, et al. Self-assembly hypoxic and ROS dual response nano prodrug as a new therapeutic approach for glaucoma treatments. Adv Sci (Weinh). 2024;11(41):e2407043.","journal-title":"Adv Sci (Weinh)"},{"key":"7214_CR14","doi-asserted-by":"publisher","first-page":"102687","DOI":"10.1016\/j.redox.2023.102687","volume":"62","author":"Z Zeng","year":"2023","unstructured":"Zeng Z, You M, Fan C, Rong R, Li H, Xia X. Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma. Redox Biol. 2023;62:102687.","journal-title":"Redox Biol"},{"key":"7214_CR15","doi-asserted-by":"publisher","first-page":"155351","DOI":"10.1016\/j.metabol.2022.155351","volume":"139","author":"H Xie","year":"2023","unstructured":"Xie H, Wang YH, Liu X, Gao J, Yang C, Huang T, et al. SUMOylation of ERp44 enhances Ero1alpha ER retention contributing to the pathogenesis of obesity and insulin resistance. Metabolism. 2023;139:155351.","journal-title":"Metabolism"},{"issue":"2","key":"7214_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s42255-024-01210-9","volume":"7","author":"Y Wang","year":"2025","unstructured":"Wang Y, Xie H, Liu Q, Wang N, Luo X, Sun F, et al. Kdm2a Inhibition in skeletal muscle improves metabolic flexibility in obesity. Nat Metab. 2025;7(2):383\u2013400.","journal-title":"Nat Metab"},{"issue":"1","key":"7214_CR17","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","volume":"11","author":"LF Campesato","year":"2020","unstructured":"Campesato LF, Budhu S, Tchaicha J, Weng CH, Gigoux M, Cohen IJ, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11(1):4011.","journal-title":"Nat Commun"},{"key":"7214_CR18","doi-asserted-by":"publisher","first-page":"115258","DOI":"10.1016\/j.ejmech.2023.115258","volume":"251","author":"H Shen","year":"2023","unstructured":"Shen H, Xu X, Bai Y, Wang X, Wu Y, Zhong J, et al. Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases. Eur J Med Chem. 2023;251:115258.","journal-title":"Eur J Med Chem"},{"key":"7214_CR19","doi-asserted-by":"publisher","first-page":"101617","DOI":"10.1016\/j.molmet.2022.101617","volume":"66","author":"H Li","year":"2022","unstructured":"Li H, Yuan Y, Chen H, Dai H, Li J. Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal\/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway. Mol Metab. 2022;66:101617.","journal-title":"Mol Metab"},{"issue":"1","key":"7214_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/bph.16208","volume":"181","author":"L Han","year":"2024","unstructured":"Han L, Ma C, Wu Z, Xu H, Li H, Pan G. AhR-STAT3-HO-1\/COX-2 signalling pathway May restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver. Br J Pharmacol. 2024;181(1):125\u201341.","journal-title":"Br J Pharmacol"},{"issue":"6","key":"7214_CR21","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/s41401-021-00781-7","volume":"43","author":"YY Li","year":"2022","unstructured":"Li YY, Wang XJ, Su YL, Wang Q, Huang SW, Pan ZF, et al. Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR\/IL-22 pathway in ILC3s. Acta Pharmacol Sin. 2022;43(6):1495\u2013507.","journal-title":"Acta Pharmacol Sin"},{"issue":"35","key":"7214_CR22","doi-asserted-by":"publisher","first-page":"e2204697","DOI":"10.1002\/advs.202204697","volume":"9","author":"B Xu","year":"2022","unstructured":"Xu B, Zhang P, Tang X, Wang S, Shen J, Zheng Y, et al. Metabolic rewiring of kynurenine pathway during hepatic Ischemia-Reperfusion injury exacerbates liver damage by impairing NAD homeostasis. Adv Sci (Weinh). 2022;9(35):e2204697.","journal-title":"Adv Sci (Weinh)"},{"issue":"9","key":"7214_CR23","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s41419-023-06135-x","volume":"14","author":"T Li","year":"2023","unstructured":"Li T, Zhao L, Li Y, Dang M, Lu J, Lu Z, et al. PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons. Cell Death Dis. 2023;14(9):634.","journal-title":"Cell Death Dis"},{"key":"7214_CR24","doi-asserted-by":"publisher","first-page":"107313","DOI":"10.1016\/j.phrs.2024.107313","volume":"207","author":"XP Wang","year":"2024","unstructured":"Wang XP, Yan D, Jin XP, Zhang WY, Shi T, Wang X, et al. The role of amino acid metabolism alterations in acute ischemic stroke: from mechanism to application. Pharmacol Res. 2024;207:107313.","journal-title":"Pharmacol Res"},{"issue":"1","key":"7214_CR25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41392-022-00971-7","volume":"7","author":"F Zhang","year":"2022","unstructured":"Zhang F, Hu G, Chen X, Zhang L, Guo L, Li C, et al. Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction. Signal Transduct Target Ther. 2022;7(1):171.","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"7214_CR26","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","volume":"35","author":"C Xue","year":"2023","unstructured":"Xue C, Li G, Zheng Q, Gu X, Shi Q, Su Y, et al. Tryptophan metabolism in health and disease. Cell Metab. 2023;35(8):1304\u201326.","journal-title":"Cell Metab"},{"issue":"10","key":"7214_CR27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.nutres.2010.09.009","volume":"30","author":"DM Christmas","year":"2010","unstructured":"Christmas DM, Badawy AA, Hince D, Davies SJ, Probert C, Creed T, et al. Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome. Nutr Res. 2010;30(10):678\u201388.","journal-title":"Nutr Res"},{"issue":"8","key":"7214_CR28","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1111\/j.1460-9568.2007.05838.x","volume":"26","author":"LG Darlington","year":"2007","unstructured":"Darlington LG, Mackay GM, Forrest CM, Stoy N, George C, Stone TW. Altered kynurenine metabolism correlates with infarct volume in stroke. Eur J Neurosci. 2007;26(8):2211\u201321.","journal-title":"Eur J Neurosci"},{"issue":"9","key":"7214_CR29","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s11064-010-0187-2","volume":"35","author":"R Brouns","year":"2010","unstructured":"Brouns R, Verkerk R, Aerts T, De Surgeloose D, Wauters A, Scharpe S, et al. The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. Neurochem Res. 2010;35(9):1315\u201322.","journal-title":"Neurochem Res"},{"issue":"1","key":"7214_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41421-024-00709-5","volume":"10","author":"H Li","year":"2024","unstructured":"Li H, Du Y, Cheng K, Chen Y, Wei L, Pei Y, et al. Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis. Cell Discov. 2024;10(1):89.","journal-title":"Cell Discov"},{"issue":"5","key":"7214_CR31","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.molcel.2022.02.007","volume":"82","author":"A Fiore","year":"2022","unstructured":"Fiore A, Zeitler L, Russier M, Gross A, Hiller MK, Parker JL, et al. Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling. Mol Cell. 2022;82(5):920\u2013e932927.","journal-title":"Mol Cell"},{"issue":"5","key":"7214_CR32","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3109\/13813455.2011.623705","volume":"117","author":"PK Munipally","year":"2011","unstructured":"Munipally PK, Agraharm SG, Valavala VK, Gundae S, Turlapati NR. Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients. Arch Physiol Biochem. 2011;117(5):254\u20138.","journal-title":"Arch Physiol Biochem"},{"key":"7214_CR33","doi-asserted-by":"crossref","unstructured":"Teunis C, Nieuwdorp M, Hanssen N. Interactions between tryptophan metabolism, the gut microbiome and the immune system as potential drivers of non-alcoholic fatty liver disease (NAFLD) and metabolic diseases. Metabolites. 2022;12(6).","DOI":"10.3390\/metabo12060514"},{"issue":"1","key":"7214_CR34","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1186\/s12967-023-04543-3","volume":"21","author":"J Wu","year":"2023","unstructured":"Wu J, Duan C, Yang Y, Wang Z, Tan C, Han C, et al. Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation. J Transl Med. 2023;21(1):712.","journal-title":"J Transl Med"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07214-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07214-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07214-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:03:33Z","timestamp":1763507013000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07214-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7214"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07214-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All serum were come from Renmin Hospital of Wuhan University. This study was approved by the Institutional Review Board of Renmin Hospital of Wuhan University (Wuhan, China; approval number: WDRY2022-K278). The study protocol and procedures of animals were approved by the Experimental Animal Ethics Committee of Renmin Hospital, Wuhan University (Approval No. WDRM-20231007F).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"All authors agree to publish and have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1299"}}