{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:39:00Z","timestamp":1781660340596,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07296-3","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:23:55Z","timestamp":1762417435000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of prenatal bifidobacterium supplementation on the gut microbiome in preterm infants of preeclamptic mothers"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8270-7859","authenticated-orcid":false,"given":"Linlin","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"issue":"7","key":"7296_CR1","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","volume":"124","author":"S Rana","year":"2019","unstructured":"Rana S, Lemoine E, Granger JP, et al. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094\u2013112","journal-title":"Circ Res"},{"issue":"10","key":"7296_CR2","first-page":"649","volume":"100","author":"L Croke","year":"2019","unstructured":"Croke L. Gestational hypertension and preeclampsia: a practice bulletin from ACOG. Am Fam Physician. 2019;100(10):649\u201350","journal-title":"Am Fam Physician"},{"issue":"19","key":"7296_CR3","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1056\/NEJMra2109523","volume":"386","author":"LA Magee","year":"2022","unstructured":"Magee LA, Nicolaides KH, von Dadelszen P. Preeclampsia. N Engl J Med. 2022;386(19):1817\u201332","journal-title":"N Engl J Med"},{"issue":"4","key":"7296_CR4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00404-016-4178-7","volume":"294","author":"J von Ehr","year":"2016","unstructured":"von Ehr J, von Versen-H\u00f6ynck F. Implications of maternal conditions and pregnancy course on offspring\u2019s medical problems in adult life. Arch Gynecol Obstet. 2016;294(4):673\u201379","journal-title":"Arch Gynecol Obstet"},{"key":"7296_CR5","first-page":"47","volume-title":"Preeclampsia; short and long-term consequences for mother and neonate","author":"A Bokslag","year":"2016","unstructured":"Bokslag A, van Weissenbruch M, Mol BW, et al. Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev; Vol. 102. 2016; p. 47\u201350"},{"issue":"3","key":"7296_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","volume":"159","author":"E Jim\u00e9nez","year":"2008","unstructured":"Jim\u00e9nez E, Mar\u00edn ML, Mart\u00edn R, et al. Is meconium from healthy newborns actually sterile? Res Microbiol. 2008;159(3):187\u201393. https:\/\/doi.org\/10.1016\/j.resmic.2007.12.007","journal-title":"Res Microbiol"},{"key":"7296_CR7","doi-asserted-by":"publisher","first-page":"579766","DOI":"10.3389\/fcimb.2021.579766","volume":"11","author":"CH Yin","year":"2021","unstructured":"Yin CH, Chen JR, Wu XN, et al. Preterm birth is correlated with increased oral originated microbiome in the gut. Front Cell Infect Microbiol. 2021;11:579766. https:\/\/doi.org\/10.3389\/fcimb.2021.579766","journal-title":"Front Cell Infect Microbiol"},{"key":"7296_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","volume":"159","author":"E Jim\u00e9nez","year":"2008","unstructured":"Jim\u00e9nez E, Mar\u00edn ML, Mart\u00edn R, et al. Is meconium from healthy newborns actually sterile? Res Microbiol. 2008;159:187\u201393. https:\/\/doi.org\/10.1016\/j.resmic.2007.12.007","journal-title":"Res Microbiol"},{"key":"7296_CR9","doi-asserted-by":"publisher","first-page":"e66986","DOI":"10.1371\/journal.pone.0066986","volume":"8","author":"L Moles","year":"2013","unstructured":"Moles L, G\u00f3mez M, Heilig H, et al. Bacterial diversity in meconium of preterm neonates and evolution of their fecal microbiota during the first month of life. PLoS One. 2013;8:e66986. https:\/\/doi.org\/10.1371\/journal.pone.0066986","journal-title":"PLoS One"},{"key":"7296_CR10","doi-asserted-by":"publisher","first-page":"e90784","DOI":"10.1371\/journal.pone.0090784","volume":"9","author":"AN Ardissone","year":"2014","unstructured":"Ardissone AN, de la Cruz DM, Davis-Richardson AG, et al. Meconium microbiome analysis identifies bacteria correlated with premature birth. PLoS One. 2014;9:e90784. https:\/\/doi.org\/10.1371\/journal.pone.0090784","journal-title":"PLoS One"},{"issue":"4","key":"7296_CR11","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/14767058.2017.1387888","volume":"32","author":"P Wilczy\u0144ska","year":"2019","unstructured":"Wilczy\u0144ska P, Skar\u017cy\u0144ska E, Lisowska-Myjak B. Meconium microbiome as a new source of information about long-term health and disease: questions and answers. J Matern Fetal Neonatal Med. 2019;32(4):681\u201386. https:\/\/doi.org\/10.1080\/14767058.2017.1387888","journal-title":"J Matern Fetal Neonatal Med"},{"key":"7296_CR12","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1126\/science.aad9378","volume":"352","author":"T Gensollen","year":"2016","unstructured":"Gensollen T, Iyer SS, Kasper DL, et al. How colonization by microbiota in early life shapes the immune system. Science. 2016;352:539\u201344. https:\/\/doi.org\/10.1126\/science.aad9378","journal-title":"Science"},{"key":"7296_CR13","doi-asserted-by":"publisher","first-page":"708472","DOI":"10.3389\/fimmu.2021.708472","volume":"12","author":"Y Yao","year":"2021","unstructured":"Yao Y, Cai X, Ye Y, et al. The role of microbiota in infant health: from early life to adulthood. Front Immunol. 2021;12:708472. https:\/\/doi.org\/10.3389\/fimmu.2021.708472","journal-title":"Front Immunol"},{"issue":"3","key":"7296_CR14","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/ncp.10490","volume":"35","author":"FR Kapourchali","year":"2020","unstructured":"Kapourchali FR, Cresci GAM. Early-life gut microbiome-the importance of maternal and infant factors in its establishment. Nutr Clin Pract. 2020;35(3):386\u2013405. https:\/\/doi.org\/10.1002\/ncp.10490","journal-title":"Nutr Clin Pract"},{"issue":"8","key":"7296_CR15","doi-asserted-by":"publisher","first-page":"e3056","DOI":"10.1371\/journal.pone.0003056","volume":"3","author":"DB DiGiulio","year":"2008","unstructured":"DiGiulio DB, Romero R, Amogan HP, et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One. 2008;3(8):e3056. https:\/\/doi.org\/10.1371\/journal.pone.0003056","journal-title":"PLoS One"},{"issue":"237","key":"7296_CR16","doi-asserted-by":"publisher","first-page":"237ra65","DOI":"10.1126\/scitranslmed.3008599","volume":"6","author":"K Aagaard","year":"2014","unstructured":"Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6(237):237ra65. https:\/\/doi.org\/10.1126\/scitranslmed.3008599","journal-title":"Sci Transl Med"},{"issue":"4","key":"7296_CR17","doi-asserted-by":"publisher","first-page":"e00036","DOI":"10.1128\/MMBR.00036-17","volume":"81","author":"C Milani","year":"2017","unstructured":"Milani C, Duranti S, Bottacini F, et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev. 2017;81(4):e00036\u201317. https:\/\/doi.org\/10.1128\/MMBR.00036-17","journal-title":"Microbiol Mol Biol Rev"},{"key":"7296_CR18","doi-asserted-by":"publisher","first-page":"226.e1","DOI":"10.1016\/j.ajog.2013.01.018","volume":"208","author":"MJ Stout","year":"2013","unstructured":"Stout MJ, Conlon B, Landeau M, et al. Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations. Am J Obstet Gynecol. 2013;208:226.e1\u2013226. https:\/\/doi.org\/10.1016\/j.ajog.2013.01.018","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"7296_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s40168-019-0766-7","volume":"7","author":"R Maqsood","year":"2019","unstructured":"Maqsood R, Rodgers R, Rodriguez C, et al. Discordant transmission of bacteria and viruses from mothers to babies at birth. Microbiome. 2019;7(1):156. https:\/\/doi.org\/10.1186\/s40168-019-0766-7","journal-title":"Microbiome"},{"issue":"1","key":"7296_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12967-025-06120-2","volume":"23","author":"Y Chen","year":"2025","unstructured":"Chen Y, Yi ZT, Yu HL, et al. Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? J Transl Med. 2025;23(1):84. https:\/\/doi.org\/10.1186\/s12967-025-06120-2","journal-title":"J Transl Med"},{"issue":"1","key":"7296_CR21","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12916-021-01991-w","volume":"19","author":"T Chen","year":"2021","unstructured":"Chen T, Qin Y, Chen M, et al. Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome. BMC Med. 2021;19(1):120. https:\/\/doi.org\/10.1186\/s12916-021-01991-w","journal-title":"BMC Med"},{"issue":"1","key":"7296_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/AOG.0000000000003018","volume":"133","author":"Obstetricians ACo","year":"2019","unstructured":"Obstetricians ACo. Gynecologists: ACOG practice bulletin no 202: gestational hypertension and preeclampsia. Obstet Gynecol. 2019;133(1):1\u201325. https:\/\/doi.org\/10.1097\/AOG.0000000000003018","journal-title":"Obstet Gynecol"},{"issue":"6","key":"7296_CR23","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.chom.2015.05.012","volume":"17","author":"F Backhed","year":"2015","unstructured":"Backhed F, Roswall J, Peng Y, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe. 2015;17(6):852. https:\/\/doi.org\/10.1016\/j.chom.2015.05.012","journal-title":"Cell Host Microbe"},{"issue":"7","key":"7296_CR24","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.4014\/jmb.2002.02042","volume":"30","author":"HJ Ku","year":"2020","unstructured":"Ku HJ, Kim YT, Lee JH. Microbiome study of initial gut microbiota from newborn infants to children reveals that diet determines its compositional development. J Microbiol Biotechnol. 2020;30(7):1067\u201371. https:\/\/doi.org\/10.4014\/jmb.2002.02042","journal-title":"J Microbiol Biotechnol"},{"issue":"10","key":"7296_CR25","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3390\/cells11101624","volume":"11","author":"L S\u00faken\u00edkov\u00e1","year":"2022","unstructured":"S\u00faken\u00edkov\u00e1 L, \u010cern\u00fd V, V\u011bcek J, et al. The impact of escherichia coli probiotic strain O83: K24: H31 on the maturation of dendritic cells and immunoregulatory functions in vitro and in vivo. Cells. 2022;11(10):1624. https:\/\/doi.org\/10.3390\/cells11101624","journal-title":"Cells"},{"issue":"1","key":"7296_CR26","doi-asserted-by":"publisher","first-page":"2095775","DOI":"10.1080\/19490976.2022.2095775","volume":"14","author":"R Jokela","year":"2022","unstructured":"Jokela R, Korpela K, Jian C, et al. Quantitative insights into effects of intrapartum antibiotics and birth mode on infant gut microbiota in relation to well-being during the first year of life. Gut Microbes. 2022;14(1):2095775. https:\/\/doi.org\/10.1080\/19490976.2022.2095775","journal-title":"Gut Microbes"},{"issue":"4","key":"7296_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/metabo10040133","volume":"10","author":"C Ceccarani","year":"2020","unstructured":"Ceccarani C, Bassanini G, Montanari C, et al. Proteobacteria overgrowth and butyrate-producing taxa depletion in the gut microbiota of glycogen storage disease type 1 patients. Metabolites. 2020;10(4):133. https:\/\/doi.org\/10.3390\/metabo10040133","journal-title":"Metabolites"},{"issue":"11","key":"7296_CR28","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.chom.2022.09.014","volume":"30","author":"S Cuesta","year":"2022","unstructured":"Cuesta S, Burdisso P, Segev A, et al. Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses. Cell Host Microbe. 2022;30(11):1615\u201329. https:\/\/doi.org\/10.1016\/j.chom.2022.09.014","journal-title":"Cell Host Microbe"},{"issue":"1","key":"7296_CR29","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13059-023-03056-y","volume":"24","author":"P Zhang","year":"2023","unstructured":"Zhang P, Wang X, Li S, et al. Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease. Genome Biol. 2023;24(1):226. https:\/\/doi.org\/10.1186\/s13059-023-03056-y","journal-title":"Genome Biol"},{"issue":"1","key":"7296_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41522-024-00499-4","volume":"10","author":"J Liu","year":"2024","unstructured":"Liu J, Yan Q, Li S, et al. Integrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis. NPJ Biofilms Microb. 2024;10(1):29. https:\/\/doi.org\/10.1038\/s41522-024-00499-4","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"10","key":"7296_CR31","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nrgastro.2016.119","volume":"13","author":"DF Ni\u00f1o","year":"2016","unstructured":"Ni\u00f1o DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nat Rev Gastroenterol Hepatol. 2016;13(10):590\u2013600. https:\/\/doi.org\/10.1038\/nrgastro.2016.119","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"7296_CR32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1042\/CS20191253","volume":"134","author":"YL Chang","year":"2020","unstructured":"Chang YL, Chen YY, Zhou Q, et al. Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia. Clin Sci (lond). 2020;134(2):289\u2013302. https:\/\/doi.org\/10.1042\/CS20191253","journal-title":"Clin Sci (lond)"},{"issue":"2","key":"7296_CR33","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/jam.14304","volume":"127","author":"W Zhang","year":"2019","unstructured":"Zhang W, Ma C, Xie P, et al. Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances. J Appl Microbiol. 2019;127(2):354\u201369. https:\/\/doi.org\/10.1111\/jam.14304","journal-title":"J Appl Microbiol"},{"key":"7296_CR34","doi-asserted-by":"publisher","unstructured":"Nordqvist M, Jacobsson B, Brants\u00e6ter AL, et al. Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway. BMJ Open. 2018; 8:e018021. https:\/\/doi.org\/10.1136\/bmjopen-2017-018021","DOI":"10.1136\/bmjopen-2017-018021"},{"issue":"5","key":"7296_CR35","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/gut.2010.223263","volume":"60","author":"M Joossens","year":"2011","unstructured":"Joossens M, Huys G, Cnockaert M, et al. Dysbiosis of the faecal microbiota in patients with Crohn\u2019s disease and their unaffected relatives. Gut. 2011;60(5):631\u201337. https:\/\/doi.org\/10.1136\/gut.2010.223263","journal-title":"Gut"},{"issue":"7480","key":"7296_CR36","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","volume":"504","author":"N Arpaia","year":"2013","unstructured":"Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480):451\u201355. https:\/\/doi.org\/10.1038\/nature12726","journal-title":"Nature"},{"issue":"2","key":"7296_CR37","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1111\/jam.15279","volume":"132","author":"W Yong","year":"2022","unstructured":"Yong W, Zhao Y, Jiang X, Li P. Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production. J Appl Microbiol. 2022;132(2):1370\u201383. https:\/\/doi.org\/10.1111\/jam.15279","journal-title":"J Appl Microbiol"},{"issue":"11","key":"7296_CR38","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.3390\/nu13114068","volume":"13","author":"C Chi","year":"2021","unstructured":"Chi C, Fan Y, Li C, et al. Early gut microbiota colonisation of premature infants Fed with breastmilk or formula with or without probiotics: a cohort study. Nutrients. 2021;13(11):4068. https:\/\/doi.org\/10.3390\/nu13114068","journal-title":"Nutrients"},{"issue":"1","key":"7296_CR39","doi-asserted-by":"publisher","first-page":"G59","DOI":"10.1152\/ajpgi.00213.2013","volume":"306","author":"ML Jensen","year":"2014","unstructured":"Jensen ML, Thymann T, Cilieborg MS, et al. Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. Am J Physiol Gastrointest Liver Physiol. 2014;306(1):G59\u201371. https:\/\/doi.org\/10.1152\/ajpgi.00213.2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7946","key":"7296_CR40","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s41586-022-05620-1","volume":"614","author":"M Valles-Colomer","year":"2023","unstructured":"Valles-Colomer M, Blanco-M\u00edguez A, Manghi P, et al. The person-to-person transmission landscape of the gut and oral microbiomes. Nature. 2023;614(7946):125\u201335. https:\/\/doi.org\/10.1038\/s41586-022-05620-1","journal-title":"Nature"},{"key":"7296_CR41","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3389\/fphys.2019.01015","volume":"10","author":"H Liu","year":"2019","unstructured":"Liu H, Pan LL, Lv S, et al. Alterations of gut microbiota and blood lipidome in gestational diabetes mellitus with hyperlipidemia. Front Physiol. 2019;10:1015. https:\/\/doi.org\/10.3389\/fphys.2019.01015","journal-title":"Front Physiol"},{"issue":"3","key":"7296_CR42","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/gutjnl-2019-319101","volume":"69","author":"X Chen","year":"2020","unstructured":"Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation. Gut. 2020;69(3):513\u201322. https:\/\/doi.org\/10.1136\/gutjnl-2019-319101","journal-title":"Gut"},{"issue":"6","key":"7296_CR43","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fcimb.2019.00224","volume":"26","author":"LJ Lv","year":"2019","unstructured":"Lv LJ, Li SH, Li SC, et al. Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women. Front Cell Infect Microbiol. 2019;26(6):224. https:\/\/doi.org\/10.3389\/fcimb.2019.00224","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07296-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07296-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07296-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:23:56Z","timestamp":1762417436000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07296-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7296"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07296-3","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"An informed consent form was signed by all volunteers and all experiments were performed in accordance with the Declaration of Helsinki. The study was approved by the Medical Ethics Committee of Chengdu Pidu District Maternal and Child Health Hospital (Approval No. 2025-56).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors have no competing interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1237"}}