{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:12:44Z","timestamp":1790302364126,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370323"],"award-info":[{"award-number":["82370323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07356-8","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:32:08Z","timestamp":1763548328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Renal denervation attenuates cardiac inflammatory responses via the afferent renal-splenic nerve axis after myocardial ischemic injury"],"prefix":"10.1186","volume":"23","author":[{"given":"Youming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-9305","authenticated-orcid":false,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"issue":"27","key":"7356_CR1","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","volume":"43","author":"S Frantz","year":"2022","unstructured":"Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J. 2022;43(27):2549\u201361.","journal-title":"EUR HEART J"},{"issue":"1","key":"7356_CR2","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1038\/s41467-022-32284-2","volume":"13","author":"SH Jung","year":"2022","unstructured":"Jung SH, Hwang BH, Shin S, Park EH, Park SH, Kim CW, Kim E, Choo E, Choi IJ, Swirski FK, et al. Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2(hi) macrophages in infarcted hearts. Nat Commun. 2022;13(1):4580.","journal-title":"NAT COMMUN"},{"issue":"1","key":"7356_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00395-022-00943-6","volume":"117","author":"SR Selejan","year":"2022","unstructured":"Selejan SR, Linz D, Mauz M, Hohl M, Huynh A, Speer T, Wintrich J, Kazakov A, Werner C, Mahfoud F, et al. Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome. Basic Res Cardiol. 2022;117(1):36.","journal-title":"BASIC RES CARDIOL"},{"issue":"2","key":"7356_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00395-020-0776-4","volume":"115","author":"X Sun","year":"2020","unstructured":"Sun X, Wei Z, Li Y, Wang J, Hu J, Yin Y, Xie J, Xu B. Renal denervation restrains the inflammatory response in myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2020;115(2):15.","journal-title":"BASIC RES CARDIOL"},{"issue":"9","key":"7356_CR5","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.jacc.2015.12.048","volume":"67","author":"P Libby","year":"2016","unstructured":"Libby P, Nahrendorf M, Swirski FK. Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: an expanded cardiovascular continuum. J AM Coll Cardiol. 2016;67(9):1091\u2013103.","journal-title":"J AM COLL CARDIOL"},{"issue":"2","key":"7356_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jcmg.2014.10.009","volume":"8","author":"H Emami","year":"2015","unstructured":"Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, et al. Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC-Cardiovasc Imag. 2015;8(2):121\u201330.","journal-title":"JACC-CARDIOVASC IMAG"},{"issue":"10","key":"7356_CR7","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1161\/CIRCRESAHA.115.307024","volume":"117","author":"YX Ye","year":"2015","unstructured":"Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, P\u00e9rez-Medina C, Mani V, et al. Imaging macrophage and hematopoietic progenitor proliferation in atherosclerosis. CIRC Res. 2015;117(10):835\u201345.","journal-title":"CIRC RES"},{"issue":"5940","key":"7356_CR8","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","volume":"325","author":"FK Swirski","year":"2009","unstructured":"Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, et al. Identification of Splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325(5940):612\u20136.","journal-title":"Science"},{"key":"7356_CR9","doi-asserted-by":"crossref","unstructured":"Halade GV, Norris PC, Kain V, Serhan CN, Ingle KA. Splenic leukocytes define the resolution of inflammation in heart failure. Sci Signal. 2018, 11(520).","DOI":"10.1126\/scisignal.aao1818"},{"issue":"18","key":"7356_CR10","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1161\/CIRCULATIONAHA.118.035628","volume":"138","author":"D Carnevale","year":"2018","unstructured":"Carnevale D. G Lembo 2018 Heart, Spleen, brain. Circulation 138 18 1917\u20139.","journal-title":"Circulation"},{"issue":"11","key":"7356_CR11","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1161\/CIRCRESAHA.123.322791","volume":"132","author":"SK Mohanta","year":"2023","unstructured":"Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht A. Cardiovascular brain circuits. Circ Res. 2023;132(11):1546\u201365.","journal-title":"CIRC RES"},{"issue":"3","key":"7356_CR12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41583-021-00555-4","volume":"23","author":"S Udit","year":"2022","unstructured":"Udit S, Blake K, Chiu IM. Somatosensory and autonomic neuronal regulation of the immune response. Nat Rev Neurosci. 2022;23(3):157\u201371.","journal-title":"NAT REV NEUROSCI"},{"issue":"39","key":"7356_CR13","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1093\/eurheartj\/ehab371","volume":"42","author":"J Hinterdobler","year":"2021","unstructured":"Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, M\u00fcller P, Mauersberger C, Vilne B, et al. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J. 2021;42(39):4077\u201388.","journal-title":"EUR HEART J"},{"issue":"5","key":"7356_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nm.4326","volume":"23","author":"K Fujiu","year":"2017","unstructured":"Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, et al. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation. Nat Med. 2017;23(5):611\u201322.","journal-title":"NAT MED"},{"key":"7356_CR15","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.3389\/fimmu.2018.03143","volume":"9","author":"LM Ince","year":"2018","unstructured":"Ince LM, Weber J, Scheiermann C. Control of leukocyte trafficking by Stress-Associated hormones. Front Immunol. 2018;9:3143.","journal-title":"FRONT IMMUNOL"},{"issue":"6","key":"7356_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41569-022-00678-w","volume":"19","author":"D Carnevale","year":"2022","unstructured":"Carnevale D. Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications. Nat Rev Cardiol. 2022;19(6):379\u201394.","journal-title":"NAT REV CARDIOL"},{"issue":"17","key":"7356_CR17","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1016\/j.jacc.2017.08.056","volume":"70","author":"DJ Polhemus","year":"2017","unstructured":"Polhemus DJ, Trivedi RK, Gao J, Li Z, Scarborough AL, Goodchild TT, Varner KJ, Xia H, Smart FW, Kapusta DR, et al. Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney. J AM Coll Cardiol. 2017;70(17):2139\u201353.","journal-title":"J AM COLL CARDIOL"},{"issue":"21","key":"7356_CR18","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.jacc.2018.08.2186","volume":"72","author":"TR Sharp","year":"2018","unstructured":"Sharp TR, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, White CJ, Kapusta DR, Lefer DJ, Goodchild TT. Renal denervation prevents heart failure progression via Inhibition of the Renin-Angiotensin system. J AM Coll Cardiol. 2018;72(21):2609\u201321.","journal-title":"J AM COLL CARDIOL"},{"issue":"2","key":"7356_CR19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1161\/HYPERTENSIONAHA.116.08373","volume":"69","author":"MT Zaldivia","year":"2017","unstructured":"Zaldivia MT, Rivera J, Hering D, Marusic P, Sata Y, Lim B, Eikelis N, Lee R, Lambert GW, Esler MD, et al. Renal denervation reduces monocyte activation and monocyte-Platelet aggregate formation: an anti-Inflammatory effect relevant for cardiovascular risk. Hypertension. 2017;69(2):323\u201331.","journal-title":"Hypertension"},{"key":"7356_CR20","doi-asserted-by":"crossref","unstructured":"Kiuchi MG, Esler MD, Fink GD, Osborn JW, Banek CT, B\u00f6hm M, Denton KM, DiBona GF, Everett TT, Grassi G et al. Renal denervation update from the International Sympathetic Nervous System Summit: JACC state-of-the-art review. J Am Coll Cardiol. 2019, 73(23):3006\u20133017.","DOI":"10.1016\/j.jacc.2019.04.015"},{"issue":"12","key":"7356_CR21","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1038\/s41440-023-01380-1","volume":"46","author":"X Hu","year":"2023","unstructured":"Hu X, Zhou H, Chen W, Li D, Du H, Xia T, Yin Y. Current problems in renal denervation and a hope to break the stage. Hypertens Res. 2023;46(12):2654\u201360.","journal-title":"HYPERTENS RES"},{"key":"7356_CR22","doi-asserted-by":"crossref","unstructured":"Evans LC, Dayton A, Osborn JW. Renal nerves in physiology, pathophysiology and interoception. Nat Rev Nephrol; 2024.","DOI":"10.1038\/s41581-024-00893-3"},{"issue":"9","key":"7356_CR23","doi-asserted-by":"publisher","first-page":"H1103","DOI":"10.1152\/ajpheart.00862.2014","volume":"308","author":"B Xu","year":"2015","unstructured":"Xu B, Zheng H, Liu X, Patel KP. Activation of afferent renal nerves modulates RVLM-projecting PVN neurons. AM J Physiol-Heart C. 2015;308(9):H1103\u201311.","journal-title":"AM J PHYSIOL-HEART C"},{"key":"7356_CR24","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fphys.2015.00224","volume":"6","author":"AM Schiller","year":"2015","unstructured":"Schiller AM, Pellegrino PR, Zucker IH. The renal nerves in chronic heart failure: efferent and afferent mechanisms. Front Physiol. 2015;6:224.","journal-title":"FRONT PHYSIOL"},{"issue":"1","key":"7356_CR25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12951-021-01016-x","volume":"19","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Cai Z, Shen Y, Lu Q, Gao W, Zhong X, Yao K, Yuan J, Liu H. Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction. J Nanobiotechnol. 2021;19(1):271.","journal-title":"J NANOBIOTECHNOL"},{"issue":"5","key":"7356_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE B\u00f8tker","year":"2018","unstructured":"B\u00f8tker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, et al. Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol. 2018;113(5):39.","journal-title":"BASIC RES CARDIOL"},{"key":"7356_CR27","doi-asserted-by":"crossref","unstructured":"Wang M, Zhang S, Han W, Ye M, Qu X, Han W. Improved renal denervation mitigated hypertension induced by angiotensin II infusion. Jove-J Vis Exp 2022;183.","DOI":"10.3791\/63719"},{"issue":"7807","key":"7356_CR28","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41586-020-2235-7","volume":"581","author":"X Zhang","year":"2020","unstructured":"Zhang X, Lei B, Yuan Y, Zhang L, Hu L, Jin S, Kang B, Liao X, Sun W, Xu F, et al. Brain control of humoral immune responses amenable to behavioural modulation. Nature. 2020;581(7807):204\u20138.","journal-title":"Nature"},{"issue":"3","key":"7356_CR29","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.immuni.2025.02.013","volume":"58","author":"S Perrotta","year":"2025","unstructured":"Perrotta S, Carnevale L, Perrotta M, Pallante F, Miko\u0142ajczyk TP, Fardella V, Migliaccio A, Fardella S, Nejat S, Kapelak B, et al. A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress. Immunity. 2025;58(3):648\u201365.","journal-title":"Immunity"},{"issue":"2","key":"7356_CR30","first-page":"R112","volume":"308","author":"JD Foss","year":"2015","unstructured":"Foss JD, Wainford RD, Engeland WC, Fink GD, Osborn JW. A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin. Am J Physiol-Reg I. 2015;308(2):R112\u201322.","journal-title":"AM J PHYSIOL-REG I"},{"key":"7356_CR31","doi-asserted-by":"publisher","first-page":"874947","DOI":"10.1155\/2014\/874947","volume":"2014","author":"Y Jin","year":"2014","unstructured":"Jin Y, Fan J, Li F, Bi L, Pei G. Local sympathetic denervation of femoral artery in a rabbit model by using 6-hydroxydopamine in situ. Biomed Res Int. 2014;2014:874947.","journal-title":"BIOMED RES INT"},{"issue":"2","key":"7356_CR32","doi-asserted-by":"publisher","first-page":"e21266","DOI":"10.1096\/fj.202001101R","volume":"35","author":"K Petkevicius","year":"2021","unstructured":"Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck X, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Faseb J. 2021;35(2):e21266.","journal-title":"FASEB J"},{"issue":"1","key":"7356_CR33","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/cvr\/cvac151","volume":"119","author":"Z Li","year":"2023","unstructured":"Li Z, Solomonidis EG, Berkeley B, Tang M, Stewart KR, Perez-Vicencio D, McCracken IR, Spiroski AM, Gray GA, Barton AK, et al. Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart. Cardiovasc Res. 2023;119(1):136\u201354.","journal-title":"CARDIOVASC RES"},{"issue":"11","key":"7356_CR34","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrneph.2017.132","volume":"13","author":"MD Okusa","year":"2017","unstructured":"Okusa MD, Rosin DL, Tracey KJ. Targeting neural reflex circuits in immunity to treat kidney disease. Nat Rev Nephrol. 2017;13(11):669\u201380.","journal-title":"NAT REV NEPHROL"},{"issue":"1","key":"7356_CR35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41392-023-01402-x","volume":"8","author":"W Cao","year":"2023","unstructured":"Cao W, Yang Z, Liu X, Ren S, Su H, Yang B, Liu Y, Wilcox CS, Hou FF. A kidney-brain neural circuit drives progressive kidney damage and heart failure. Signal Transduct Tar. 2023;8(1):184.","journal-title":"SIGNAL TRANSDUCT TAR"},{"issue":"1","key":"7356_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1161\/ATVBAHA.123.318230","volume":"44","author":"S Perrotta","year":"2024","unstructured":"Perrotta S, Carnevale D. Brain-Splenic immune system interactions in hypertension: cellular and molecular mechanisms. Arterioscl Throm Vas. 2024;44(1):65\u201375.","journal-title":"ARTERIOSCL THROM VAS"},{"issue":"6","key":"7356_CR37","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","volume":"46","author":"SS Chavan","year":"2017","unstructured":"Chavan SS, Pavlov VA, Tracey KJ. Mechanisms and therapeutic relevance of Neuro-immune communication. Immunity. 2017;46(6):927\u201342.","journal-title":"Immunity"},{"issue":"7","key":"7356_CR38","doi-asserted-by":"publisher","first-page":"e182416","DOI":"10.1371\/journal.pone.0182416","volume":"12","author":"K Murray","year":"2017","unstructured":"Murray K, Godinez DR, Brust-Mascher I, Miller EN, Gareau MG, Reardon C. Neuroanatomy of the spleen: mapping the relationship between sympathetic neurons and lymphocytes. PLoS One. 2017;12(7):e182416.","journal-title":"PLoS ONE"},{"issue":"11","key":"7356_CR39","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41577-023-00857-x","volume":"23","author":"YO Alexandre","year":"2023","unstructured":"Alexandre YO, Mueller SN. Splenic stromal niches in homeostasis and immunity. Nat Rev Immunol. 2023;23(11):705\u201319.","journal-title":"NAT REV IMMUNOL"},{"issue":"6052","key":"7356_CR40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1209985","volume":"334","author":"M Rosas-Ballina","year":"2011","unstructured":"Rosas-Ballina M, Olofsson PS, Ochani M, Vald\u00e9s-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011;334(6052):98\u2013101.","journal-title":"Science"},{"issue":"2","key":"7356_CR41","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/cvr\/cvx227","volume":"114","author":"KA Ziegler","year":"2018","unstructured":"Ziegler KA, Ahles A, Wille T, Kerler J, Ramanujam D, Engelhardt S. Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice. Cardiovasc Res. 2018;114(2):291\u20139.","journal-title":"CARDIOVASC RES"},{"issue":"9","key":"7356_CR42","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nri2156","volume":"7","author":"K Ley","year":"2007","unstructured":"Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7(9):678\u201389.","journal-title":"NAT REV IMMUNOL"},{"issue":"6359","key":"7356_CR43","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1126\/science.aam9690","volume":"358","author":"J Wang","year":"2017","unstructured":"Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the function and fate of neutrophils in sterile injury and repair. Science. 2017;358(6359):111\u20136.","journal-title":"Science"},{"issue":"4","key":"7356_CR44","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.immuni.2023.01.024","volume":"56","author":"H Janssen","year":"2023","unstructured":"Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D\u2019Souza D, McAlpine CS, Halle L, Poller WC, et al. Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Immunity. 2023;56(4):783\u201396.","journal-title":"Immunity"},{"issue":"5","key":"7356_CR45","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.smim.2014.01.003","volume":"26","author":"CJ Padro","year":"2014","unstructured":"Padro CJ, Sanders VM. Neuroendocrine regulation of inflammation. Semin Immunol. 2014;26(5):357\u201368.","journal-title":"SEMIN IMMUNOL"},{"issue":"2","key":"7356_CR46","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1161\/CIRCULATIONAHA.116.022304","volume":"134","author":"LA Grisanti","year":"2016","unstructured":"Grisanti LA, Gumpert AM, Traynham CJ, Gorsky JE, Repas AA, Gao E, Carter RL, Yu D, Calvert JW, Garc\u00eda AP, et al. Leukocyte-Expressed \u03b22-Adrenergic receptors are essential for survival after acute myocardial injury. Circulation. 2016;134(2):153\u201367.","journal-title":"Circulation"},{"issue":"12","key":"7356_CR47","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1038\/s41588-022-01191-z","volume":"54","author":"J Ablain","year":"2022","unstructured":"Ablain J, Al MA, Rothschild H, Prasad M, Aires S, Yang S, Dokukin ME, Xu S, Dang M, Sokolov I, et al. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 2022;54(12):1839\u201352.","journal-title":"NAT GENET"},{"issue":"1","key":"7356_CR48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/sj.mt.6300009","volume":"15","author":"Z Yu","year":"2007","unstructured":"Yu Z, Adusumilli PS, Eisenberg DP, Darr E, Ghossein RA, Li S, Liu S, Singh B, Shah JP, Fong Y, et al. Nectin-1 expression by squamous cell carcinoma is a predictor of herpes oncolytic sensitivity. Mol Ther. 2007;15(1):103\u201313.","journal-title":"MOL THER"},{"key":"7356_CR49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ijbiomac.2021.07.170","volume":"188","author":"T Zhang","year":"2021","unstructured":"Zhang T, Liu Y, Chen Y, Wang J, Feng H, Wei Q, Zhao S, Yang S, Liu D, Zhang G. A monoclonal antibody neutralizes pesudorabies virus by blocking gD binding to the receptor nectin-1. Int J Biol Macromol. 2021;188:359\u201368.","journal-title":"INT J BIOL MACROMOL"},{"issue":"6","key":"7356_CR50","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cell.2008.01.043","volume":"132","author":"T Satoh","year":"2008","unstructured":"Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, et al. PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell. 2008;132(6):935\u201344.","journal-title":"Cell"},{"issue":"11","key":"7356_CR51","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s00018-022-04557-y","volume":"79","author":"N Navarro","year":"2022","unstructured":"Navarro N, Molist C, Sansa-Girona J, Zarzosa P, Gallo-Oller G, Pons G, Magdaleno A, Guill\u00e9n G, Hladun R, Garrido M, et al. Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma. Cell Mol Life Sci. 2022;79(11):546.","journal-title":"CELL MOL LIFE SCI"},{"issue":"14","key":"7356_CR52","doi-asserted-by":"publisher","first-page":"5935","DOI":"10.1167\/iovs.16-20130","volume":"57","author":"GJ Kang","year":"2016","unstructured":"Kang GJ, Truong T, Huang E, Su V, Ge S, Chen L. Integrin alpha 9 Blockade suppresses lymphatic valve formation and promotes transplant survival. Invest Ophth Vis Sci. 2016;57(14):5935\u20139.","journal-title":"INVEST OPHTH VIS SCI"},{"issue":"10","key":"7356_CR53","doi-asserted-by":"publisher","first-page":"7131","DOI":"10.3168\/jds.2022-22709","volume":"106","author":"B Zhang","year":"2023","unstructured":"Zhang B, Zhang W, He Y, Ma X, Li M, Jiang Q, Loor JJ, Lv X, Yang W, Xu C. Store-operated Ca(2+) entry-sensitive Glycolysis regulates neutrophil adhesion and phagocytosis in dairy cows with subclinical hypocalcemia. J Dairy Sci. 2023;106(10):7131\u201346.","journal-title":"J DAIRY SCI"},{"key":"7356_CR54","doi-asserted-by":"publisher","first-page":"117487","DOI":"10.1016\/j.cca.2023.117487","volume":"548","author":"V Singh","year":"2023","unstructured":"Singh V, Kaur R, Kumari P, Pasricha C, Singh R. ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders. Clin Chim Acta. 2023;548:117487.","journal-title":"CLIN CHIM ACTA"},{"issue":"6","key":"7356_CR55","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","volume":"33","author":"M Algoet","year":"2023","unstructured":"Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J, Oosterlinck W. Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovas Med. 2023;33(6):357\u201366.","journal-title":"TRENDS CARDIOVAS MED"},{"issue":"18","key":"7356_CR56","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1093\/cvr\/cvae196","volume":"120","author":"W Hu","year":"2025","unstructured":"Hu W, Tu H, Wadman MC, Li YL, Zhang D. Renal denervation achieves its antiarrhythmic effect through attenuating macrophage activation and neuroinflammation in stellate ganglia in chronic heart failure. Cardiovasc Res. 2025;120(18):2420\u201333.","journal-title":"CARDIOVASC RES"},{"issue":"7","key":"7356_CR57","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/ejhf.2209","volume":"23","author":"F M\u00e1lek","year":"2021","unstructured":"M\u00e1lek F, Gajewski P, Zymli\u0144ski R, Janczak D, Chabowski M, Fudim M, Martinca T, Neu\u017eil P, Biegus J, Mates M, et al. Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first-in-human clinical trial. Eur J Heart Fail. 2021;23(7):1134\u201343.","journal-title":"EUR J HEART FAIL"},{"key":"7356_CR58","doi-asserted-by":"crossref","unstructured":"Wang XL, Wang JX, Chen JL, Hao WY, Xu WZ, Xu ZQ, Jiang YT, Luo PQ, Chen Q, Li YH et al. Asprosin in the paraventricular nucleus induces sympathetic activation and pressor responses via cAMP-Dependent ROS production. Int J Mol Sci 2022;23(20).","DOI":"10.3390\/ijms232012595"},{"key":"7356_CR59","doi-asserted-by":"publisher","first-page":"858941","DOI":"10.3389\/fphys.2022.858941","volume":"13","author":"B Savi\u0107","year":"2022","unstructured":"Savi\u0107 B, Murphy D, Japund\u017ei\u0107-\u017digon N. The paraventricular nucleus of the hypothalamus in control of blood pressure and blood pressure variability. Front Physiol. 2022;13:858941.","journal-title":"FRONT PHYSIOL"},{"issue":"1","key":"7356_CR60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s12264-018-0316-5","volume":"35","author":"JJ Zhou","year":"2019","unstructured":"Zhou JJ, Ma HJ, Shao JY, Pan HL, Li DP. Impaired hypothalamic regulation of sympathetic outflow in primary hypertension. Neurosci Bull. 2019;35(1):124\u201332.","journal-title":"NEUROSCI BULL"},{"issue":"1","key":"7356_CR61","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41573-021-00284-4","volume":"21","author":"RJ Slack","year":"2022","unstructured":"Slack RJ, Macdonald S, Roper JA, Jenkins RG, Hatley R. Emerging therapeutic opportunities for integrin inhibitors. Nat Rev Drug Discov. 2022;21(1):60\u201378.","journal-title":"NAT REV DRUG DISCOV"},{"key":"7356_CR62","doi-asserted-by":"crossref","unstructured":"Kong DH, Kim YK, Kim MR, Jang JH, Lee S. Emerging roles of vascular cell adhesion Molecule-1 (VCAM-1) in immunological disorders and cancer. Int J Mol Sci 2018, 19(4).","DOI":"10.3390\/ijms19041057"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07356-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07356-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07356-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:04:28Z","timestamp":1763553868000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07356-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7356"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07356-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Institutional Animal Care and Use Committee of Tongji University and conformed to the guidelines of Directive 2010\/63\/EU of the European Parliament for the protection of animals used for scientific purposes and the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1320"}}