{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:44:17Z","timestamp":1792500257032,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07357-7","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:21:40Z","timestamp":1763547700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The epidermal growth factor receptor regulates YAP signalling and promotes diabetic retinal fibrosis by modulating the degradation of SAV1"],"prefix":"10.1186","volume":"23","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"7357_CR1","doi-asserted-by":"publisher","unstructured":"Soare C, Grimaldi G, Rees A. Late recurrence of acute retinal necrosis within retinal scars. Ophthalmology. 2020 Dec;127(12):1754. https:\/\/doi.org\/10.1016\/j.ophtha.2020.07.034.","DOI":"10.1016\/j.ophtha.2020.07.034"},{"key":"7357_CR2","doi-asserted-by":"publisher","first-page":"100966","DOI":"10.1016\/j.preteyeres.2021.100966","volume":"85","author":"I Van Hove","year":"2021","unstructured":"Van Hove I, Hu TT, Beets K, et al. Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration. Prog Retin Eye Res. 2021 Nov;85:100966. https:\/\/doi.org\/10.1016\/j.preteyeres.2021.100966.","journal-title":"Prog Retin Eye Res"},{"key":"7357_CR3","doi-asserted-by":"publisher","first-page":"100906","DOI":"10.1016\/j.preteyeres.2020.100906","volume":"82","author":"PS Mettu","year":"2021","unstructured":"Mettu PS, Allingham MJ, Cousins SW. Incomplete response to anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities. Prog Retin Eye Res. 2021 May;82:100906. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100906.","journal-title":"Prog Retin Eye Res"},{"key":"7357_CR4","doi-asserted-by":"publisher","unstructured":"Juncheed K, Kohlstrunk B, Friebe S, et al. Employing nanostructured scaffolds to investigate the mechanical properties of adult mammalian retinae under tension. Int J Mol Sci. 2020 May 29;21(11). https:\/\/doi.org\/10.3390\/ijms21113889.","DOI":"10.3390\/ijms21113889"},{"key":"7357_CR5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.omtn.2021.12.019","volume":"27","author":"Y Liu","year":"2022","unstructured":"Liu Y, Yang Q, Fu H, et al. M\u00fcller glia-derived exosomal miR-9-3p promotes angiogenesis by restricting sphingosine-1-phosphate receptor S1P(1) in diabetic retinopathy. Mol Ther Nucleic Acids. 2022 Mar 8;27:491\u2013504. https:\/\/doi.org\/10.1016\/j.omtn.2021.12.019.","journal-title":"Mol Ther Nucleic Acids"},{"key":"7357_CR6","doi-asserted-by":"publisher","unstructured":"Chan CM, Hsiao CY, Li HJ, Fang JY, Chang DC, Hung CF. The inhibitory effects of gold nanoparticles on VEGF-A-induced cell migration in choroid-Retina endothelial cells. Int J Mol Sci. 2019 Dec 23;21(1). https:\/\/doi.org\/10.3390\/ijms21010109.","DOI":"10.3390\/ijms21010109"},{"key":"7357_CR7","doi-asserted-by":"publisher","unstructured":"Carpi-Santos R, de Melo Reis RA, Gomes FCA, Calaza KC. Contribution of M\u00fcller cells in the diabetic retinopathy development: focus on oxidative stress and inflammation. Antioxidants (Basel). 2022 Mar 23;11(4). https:\/\/doi.org\/10.3390\/antiox11040617.","DOI":"10.3390\/antiox11040617"},{"issue":"1","key":"7357_CR8","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/s41598-022-05284-x","volume":"12","author":"JS Albert-Garay","year":"2022","unstructured":"Albert-Garay JS, Riesgo-Escovar JR, Salceda R. High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat M\u00fcller retinal cells in vitro. Sci Rep. 2022 Jan 24;12(1):1261. https:\/\/doi.org\/10.1038\/s41598-022-05284-x.","journal-title":"Sci Rep"},{"issue":"1","key":"7357_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1186\/s12974-020-02033-7","volume":"17","author":"K Little","year":"2020","unstructured":"Little K, Llori\u00e1n-Salvador M, Tang M, et al. Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration. J Neuroinflammation. 2020 Nov 25;17(1):355. https:\/\/doi.org\/10.1186\/s12974-020-02033-7.","journal-title":"J Neuroinflammation"},{"issue":"6","key":"7357_CR10","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.survophthal.2021.03.001","volume":"66","author":"Y Tan","year":"2021","unstructured":"Tan Y, Fukutomi A, Sun MT, Durkin S, Gilhotra J, Chan WO. Anti-VEGF crunch syndrome in proliferative diabetic retinopathy: a review. Surv Ophthalmol. 2021 Nov-Dec;66(6):926\u201332. https:\/\/doi.org\/10.1016\/j.survophthal.2021.03.001.","journal-title":"Surv Ophthalmol"},{"issue":"8","key":"7357_CR11","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s41419-021-04041-8","volume":"12","author":"Z Zheng","year":"2021","unstructured":"Zheng Z, Li C, Shao G, et al. Hippo-YAP\/MCP-1 mediated tubular maladaptive repair promote inflammation in renal failed recovery after ischemic AKI. Cell Death Dis. 2021 Jul 30;12(8):754. https:\/\/doi.org\/10.1038\/s41419-021-04041-8.","journal-title":"Cell Death Dis"},{"key":"7357_CR12","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.2147\/dmso.S302466","volume":"14","author":"M Hu","year":"2021","unstructured":"Hu M, Wang H, Li S, et al. Yes-associated protein is involved in myocardial fibrosis in rats with diabetic cardiomyopathy. Diabetes Metab Syndr Obes. 2021;14:2133\u201343. https:\/\/doi.org\/10.2147\/dmso.S302466.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"1","key":"7357_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s11658-025-00760-4","volume":"30","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, He P, Yang L, Gong J, Qin R, Wang M. Posttranslational modifications of YAP\/TAZ: molecular mechanisms and therapeutic opportunities. Cell Mol Biol Lett. 2025 Jul 17;30(1):83. https:\/\/doi.org\/10.1186\/s11658-025-00760-4.","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"7357_CR14","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s13287-025-04438-8","volume":"16","author":"SM Alnasser","year":"2025","unstructured":"Alnasser SM, Alrobian AS, Alfayez MS, Almutairi OT, Almutairi SS, Alkeraidees TS. Pharmacological modulation of stem cells signaling pathway for therapeutic applications. STEM Cell Res Ther. 2025 Jul 1;16(1):327. https:\/\/doi.org\/10.1186\/s13287-025-04438-8.","journal-title":"STEM Cell Res Ther"},{"key":"7357_CR15","doi-asserted-by":"publisher","unstructured":"Li S, Hao L, Li N, et al. Targeting the Hippo\/YAP1 signaling pathway in hepatocellular carcinoma: from mechanisms to therapeutic drugs (Review). Int J Oncol. 2024 Sep;65(3). https:\/\/doi.org\/10.3892\/ijo.2024.5676.","DOI":"10.3892\/ijo.2024.5676"},{"issue":"8","key":"7357_CR16","doi-asserted-by":"publisher","first-page":"116076","DOI":"10.1016\/j.celrep.2025.116076","volume":"44","author":"X Huang","year":"2025","unstructured":"Huang X, Wang J, Liu Y, Pan H, Zheng K, Liu B. The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. Cell Rep. 2025 Jul 26;44(8):116076. https:\/\/doi.org\/10.1016\/j.celrep.2025.116076.","journal-title":"Cell Rep"},{"key":"7357_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2025.05.017","author":"X Cao","year":"2025","unstructured":"Cao X, Lu Z, Fang Y, et al. RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1\/2. Dev Cell. 2025 Jun 19. https:\/\/doi.org\/10.1016\/j.devcel.2025.05.017.","journal-title":"Dev Cell"},{"key":"7357_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-025-01099-2","author":"J Wang","year":"2025","unstructured":"Wang J, Jing K, Mitrokhin V, et al. Crosstalk between MST1-Hippo and Wnt\/\u03b2-catenin, notch, and PI3K\/Akt pathways in cardiac physiology and pathology. J Physiol Biochem. 2025 Jun 9. https:\/\/doi.org\/10.1007\/s13105-025-01099-2.","journal-title":"J Physiol Biochem"},{"key":"7357_CR19","doi-asserted-by":"publisher","first-page":"657378","DOI":"10.3389\/fphys.2021.657378","volume":"12","author":"J Xiong","year":"2021","unstructured":"Xiong J, Dong X, Li S, et al. Effects of (Pro)renin receptor on diabetic cardiomyopathy pathological processes in rats via the PRR-AMPK-YAP pathway. Front Physiol. 2021;12:657378. https:\/\/doi.org\/10.3389\/fphys.2021.657378.","journal-title":"Front Physiol"},{"key":"7357_CR20","doi-asserted-by":"publisher","first-page":"3399357","DOI":"10.1155\/2021\/3399357","volume":"2021","author":"C Li","year":"2021","unstructured":"Li C, Zhang R, Zhan Y, Zheng J. Resveratrol inhibits hepatic stellate cell activation via the Hippo Pathway. Mediators Inflamm. 2021;2021:3399357. https:\/\/doi.org\/10.1155\/2021\/3399357.","journal-title":"Mediators Inflamm"},{"key":"7357_CR21","doi-asserted-by":"publisher","first-page":"103452","DOI":"10.1016\/j.ebiom.2021.103452","volume":"69","author":"W Ou","year":"2021","unstructured":"Ou W, Xu W, Liu F, et al. Increased expression of yes-associated protein\/YAP and transcriptional coactivator with PDZ-binding motif\/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn\u2019s disease. EBioMedicine. 2021 Jul;69:103452. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103452.","journal-title":"EBioMedicine"},{"issue":"9","key":"7357_CR22","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2337\/db17-1513","volume":"67","author":"Z Li","year":"2018","unstructured":"Li Z, Li Y, Overstreet JM, et al. Inhibition of epidermal growth factor receptor activation is associated with improved diabetic nephropathy and insulin resistance in type 2 diabetes. Diabetes. 2018 Sep;67(9):1847\u201357. https:\/\/doi.org\/10.2337\/db17-1513.","journal-title":"Diabetes"},{"issue":"3","key":"7357_CR23","doi-asserted-by":"publisher","first-page":"37010","DOI":"10.1289\/ehp8222","volume":"129","author":"JE Hardesty","year":"2021","unstructured":"Hardesty JE, Wahlang B, Prough RA, et al. Effect of epidermal growth factor treatment and polychlorinated biphenyl exposure in a dietary-exposure mouse Model of steatohepatitis. Environ Health Perspect. 2021 Mar;129(3):37010. https:\/\/doi.org\/10.1289\/ehp8222.","journal-title":"Environ Health Perspect"},{"issue":"1","key":"7357_CR24","doi-asserted-by":"publisher","first-page":"7316","DOI":"10.1038\/s41467-021-27612-x","volume":"12","author":"J Zindel","year":"2021","unstructured":"Zindel J, Mittner J, Bayer J, et al. Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling. Nat Commun. 2021 Dec 16;12(1):7316. https:\/\/doi.org\/10.1038\/s41467-021-27612-x.","journal-title":"Nat Commun"},{"key":"7357_CR25","doi-asserted-by":"publisher","unstructured":"Chiusa M, Hu W, Zienkiewicz J, et al. EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling. J Cell Biol. 2020 Sep 7;219(9). https:\/\/doi.org\/10.1083\/jcb.202001120.","DOI":"10.1083\/jcb.202001120"},{"key":"7357_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fcell.2020.00079","volume":"8","author":"M Mossahebi-Mohammadi","year":"2020","unstructured":"Mossahebi-Mohammadi M, Quan M, Zhang JS, Li X. FGF signaling pathway: a key regulator of stem cell pluripotency. Front Cell Dev Biol. 2020;8:79. https:\/\/doi.org\/10.3389\/fcell.2020.00079.","journal-title":"Front. Cell Dev. Biol"},{"issue":"9","key":"7357_CR27","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.7150\/thno.31424","volume":"9","author":"L Xu","year":"2019","unstructured":"Xu L, Li X, Zhang F, Wu L, Dong Z, Zhang D. EGFR drives the progression of AKI to CKD through HIPK2 overexpression. Theranostics. 2019;9(9):2712\u201326. https:\/\/doi.org\/10.7150\/thno.31424.","journal-title":"Theranostics"},{"issue":"1","key":"7357_CR28","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/s42003-021-02386-6","volume":"4","author":"P Shang","year":"2021","unstructured":"Shang P, Stepicheva N, Teel K, et al. \u03b2A3\/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021 Jul 8;4(1):850. https:\/\/doi.org\/10.1038\/s42003-021-02386-6.","journal-title":"Commun Biol"},{"issue":"4","key":"7357_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.18240\/ijo.2021.04.02","volume":"14","author":"T Li","year":"2021","unstructured":"Li T, Zhang HB, Meng JM, et al. YM155 inhibits retinal pigment epithelium cell survival through EGFR\/MAPK signaling pathway. Int J Ophthalmol. 2021;14(4):489\u201396. https:\/\/doi.org\/10.18240\/ijo.2021.04.02.","journal-title":"Int J Ophthalmol"},{"issue":"11","key":"7357_CR30","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1038\/s41556-020-00588-4","volume":"22","author":"A Aharonov","year":"2020","unstructured":"Aharonov A, Shakked A, Umansky KB, et al. ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol. 2020 Nov;22(11):1346\u201356. https:\/\/doi.org\/10.1038\/s41556-020-00588-4.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"7357_CR31","doi-asserted-by":"publisher","first-page":"114087","DOI":"10.1016\/j.yexcr.2024.114087","volume":"439","author":"Z Chen","year":"2024","unstructured":"Chen Z, Liu B, Zhou D, et al. AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4. Exp Cell Res. 2024 May 11;439(1):114087. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114087.","journal-title":"Exp Cell Res"},{"issue":"10","key":"7357_CR32","doi-asserted-by":"publisher","first-page":"e23671","DOI":"10.1096\/fj.202301922RR","volume":"38","author":"S Gao","year":"2024","unstructured":"Gao S, Li N, Lin Z, Zhong Y, Wang Y, Shen X. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in M\u00fcller glia. Faseb J. 2024 May 31;38(10):e23671. https:\/\/doi.org\/10.1096\/fj.202301922RR.","journal-title":"Faseb J"},{"issue":"21","key":"7357_CR33","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1111\/jcmm.15739","volume":"24","author":"W Zhang","year":"2020","unstructured":"Zhang W, Kong Y. YAP is essential for TGF-\u03b2-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of M\u00fcller cells. J Cell Mol Med. 2020 Nov;24(21):12390\u2013400. https:\/\/doi.org\/10.1111\/jcmm.15739.","journal-title":"J Cell Mol Med"},{"key":"7357_CR34","doi-asserted-by":"publisher","first-page":"108677","DOI":"10.1016\/j.exer.2021.108677","volume":"209","author":"W Zhang","year":"2021","unstructured":"Zhang W, Han H. Targeting matrix stiffness-induced activation of retinal pigment epithelial cells through the RhoA\/YAP pathway ameliorates proliferative vitreoretinopathy. Exp Eye Res. 2021 Aug;209:108677. https:\/\/doi.org\/10.1016\/j.exer.2021.108677.","journal-title":"Exp Eye Res"},{"issue":"8","key":"7357_CR35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.63.8.24","volume":"63","author":"W Zhang","year":"2022","unstructured":"Zhang W, Li J. EGF receptor signaling modulates YAP activation and promotes experimental proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):24. https:\/\/doi.org\/10.1167\/iovs.63.8.24.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"7357_CR36","doi-asserted-by":"publisher","first-page":"e112863","DOI":"10.15252\/embj.2022112863","volume":"42","author":"TT Bonello","year":"2023","unstructured":"Bonello TT, Cai D, Fletcher GC, et al. Phase separation of Hippo signalling complexes. EMBO J. 2023 Mar 15;42(6):e112863. https:\/\/doi.org\/10.15252\/embj.2022112863.","journal-title":"The EMBO J"},{"issue":"9","key":"7357_CR37","doi-asserted-by":"publisher","first-page":"111296","DOI":"10.1016\/j.celrep.2022.111296","volume":"40","author":"Y Gu","year":"2022","unstructured":"Gu Y, Wang Y, Sha Z, et al. Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP\/TAZ-active cancers. Cell Rep. 2022 Aug 30;40(9):111296. https:\/\/doi.org\/10.1016\/j.celrep.2022.111296.","journal-title":"Cell Rep"},{"issue":"3","key":"7357_CR38","first-page":"864","volume":"43","author":"GA Limb","year":"2002","unstructured":"Limb GA, Salt TE, Munro PM, Moss SE, Khaw PT. In vitro characterization of a spontaneously immortalized human M\u00fcller cell line (MIO-M1). Invest Ophthalmol Vis Sci. 2002 Mar;43(3):864\u201369.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7357_CR39","doi-asserted-by":"publisher","first-page":"101927","DOI":"10.1016\/j.molmet.2024.101927","volume":"83","author":"J Li","year":"2024","unstructured":"Li J, Huang Y, Yang X, et al. Tyrosine-phosphorylated dner sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3. Mol Metab. 2024 May;83:101927. https:\/\/doi.org\/10.1016\/j.molmet.2024.101927.","journal-title":"Mol Metab"},{"issue":"10","key":"7357_CR40","doi-asserted-by":"publisher","first-page":"13654","DOI":"10.1096\/fj.202001095RR","volume":"34","author":"L Dong","year":"2020","unstructured":"Dong L, Shi XH, Li YF, et al. Blockade of epidermal growth factor and its receptor and axial elongation in experimental myopia. Faseb J. 2020 Oct;34(10):13654\u201370. https:\/\/doi.org\/10.1096\/fj.202001095RR.","journal-title":"Faseb J"},{"issue":"6","key":"7357_CR41","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1681\/asn.2015040415","volume":"27","author":"J Chen","year":"2016","unstructured":"Chen J, Harris RC. Interaction of the EGF receptor and the Hippo pathway in the diabetic kidney. J Am Soc Nephrol. 2016 Jun;27(6):1689\u2013700. https:\/\/doi.org\/10.1681\/asn.2015040415.","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"7357_CR42","doi-asserted-by":"publisher","first-page":"349","DOI":"10.21037\/tcr-20-698","volume":"10","author":"F Huang","year":"2021","unstructured":"Huang F, Tang X, Sun T, Wang G, Ru Q, Zheng Y. SAV1, regulated by HERC4, inhibits the proliferation, migration, and invasion of hepatocellular carcinoma. Transl Cancer Res. 2021 Jan;10(1):349\u201360. https:\/\/doi.org\/10.21037\/tcr-20-698.","journal-title":"Transl Cancer Res"},{"issue":"1","key":"7357_CR43","doi-asserted-by":"publisher","first-page":"9334","DOI":"10.1038\/s41467-024-53601-x","volume":"15","author":"Y Lei","year":"2024","unstructured":"Lei Y, Liu Q, Chen B, et al. Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy. Nat Commun. 2024 Oct 29;15(1):9334. https:\/\/doi.org\/10.1038\/s41467-024-53601-x.","journal-title":"Nat Commun"},{"key":"7357_CR44","doi-asserted-by":"publisher","unstructured":"Papavassiliou KA, Sofianidi AA, Spiliopoulos FG, Gogou VA, Gargalionis AN, Papavassiliou AG. YAP\/TAZ signaling in the pathobiology of pulmonary fibrosis. Cells. 2024 Sep 10;13(18). https:\/\/doi.org\/10.3390\/cells13181519.","DOI":"10.3390\/cells13181519"},{"issue":"3","key":"7357_CR45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s12264-024-01308-w","volume":"41","author":"L Lin","year":"2025","unstructured":"Lin L, Yuan Y, Huang Z, Wang Y. YAP signaling in glia: pivotal roles in neurological development, regeneration and diseases. Neurosci Bull. 2025 Mar;41(3):501\u201319. https:\/\/doi.org\/10.1007\/s12264-024-01308-w.","journal-title":"Neurosci Bull"},{"key":"7357_CR46","doi-asserted-by":"publisher","unstructured":"Zhong B, Du J, Liu F, Sun S. The role of yes-associated protein in inflammatory diseases and cancer. MedComm (2020). 2025 Mar;6(3):e70128. https:\/\/doi.org\/10.1002\/mco2.70128.","DOI":"10.1002\/mco2.70128"},{"key":"7357_CR47","doi-asserted-by":"publisher","DOI":"10.1681\/asn.0000000830","author":"J Chen","year":"2025","unstructured":"Chen J, Peng F, Jiang M, et al. Epidermal growth factor receptor activation stimulates SOX9 expression in injured renal proximal tubule epithelial cells. J Am Soc Nephrol. 2025 Sep 2. https:\/\/doi.org\/10.1681\/asn.0000000830.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"7357_CR48","doi-asserted-by":"publisher","first-page":"428","DOI":"10.34172\/apb.43809","volume":"15","author":"A Somayaji","year":"2025","unstructured":"Somayaji A, Shastry CS. Synergistic enhancement of osimertinib efficacy in non-small cell lung cancer cells through epigallocatechin-3-gallate: mechanistic insights into YAP\/TEAD\/CTGF axis inhibition. Adv Pharm Bull. 2025 Jul;15(2):428\u201339. https:\/\/doi.org\/10.34172\/apb.43809.","journal-title":"Adv Pharm Bull"},{"issue":"1","key":"7357_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10799893.2020.1783556","volume":"41","author":"L Zhou","year":"2021","unstructured":"Zhou L, Zhang S, Zhang L, Li F, Sun H, Feng J. MiR-199a-3p inhibits the proliferation, migration, and invasion of endothelial cells and retinal pericytes of diabetic retinopathy rats through regulating FGF7 via EGFR\/PI3K\/AKT pathway. J Recept Signal Transduct Res. 2021 Feb;41(1):19\u201331. https:\/\/doi.org\/10.1080\/10799893.2020.1783556.","journal-title":"J Recept Signal Transduct Res"},{"issue":"1","key":"7357_CR50","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1038\/s41467-019-09780-z","volume":"10","author":"E Kim","year":"2019","unstructured":"Kim E, Lisby A, Ma C, et al. Promotion of growth factor signaling as a critical function of \u03b2-catenin during HCC progression. Nat Commun. 2019 Apr 23;10(1):1909. https:\/\/doi.org\/10.1038\/s41467-019-09780-z.","journal-title":"Nat Commun"},{"issue":"11","key":"7357_CR51","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/s41419-021-04350-y","volume":"12","author":"AW Qiu","year":"2021","unstructured":"Qiu AW, Huang DR, Li B, Fang Y, Zhang WW, Liu QH. IL-17A injury to retinal ganglion cells is mediated by retinal M\u00fcller cells in diabetic retinopathy. Cell Death Dis. 2021 Nov 8;12(11):1057. https:\/\/doi.org\/10.1038\/s41419-021-04350-y.","journal-title":"Cell Death Dis"},{"issue":"2","key":"7357_CR52","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/jme-21-0123","volume":"68","author":"J Zhang","year":"2022","unstructured":"Zhang J, Chen C, Wu L, et al. Synoviolin inhibits the inflammatory cytokine secretion of M\u00fcller cells by reducing NLRP3. J Mol Endocrinol. 2022 Jan 25;68(2):125\u201336. https:\/\/doi.org\/10.1530\/jme-21-0123.","journal-title":"J Mol Endocrinol"},{"issue":"8","key":"7357_CR53","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1080\/08916934.2021.1969551","volume":"54","author":"J Zhang","year":"2021","unstructured":"Zhang J, Chen C, Zhang S, Chen J, Wu L, Chen Z. LncRNA xist restrains the activation of M\u00fcller cells and inflammation in diabetic retinopathy via stabilizing SIRT1. Autoimmunity. 2021 Dec;54(8):504\u201313. https:\/\/doi.org\/10.1080\/08916934.2021.1969551.","journal-title":"Autoimmunity"},{"issue":"9","key":"7357_CR54","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1681\/asn.2017121272","volume":"29","author":"J Chen","year":"2018","unstructured":"Chen J, You H, Li Y, Xu Y, He Q, Harris RC. EGF receptor-dependent YAP activation is important for renal recovery from AKI. J Am Soc Nephrol. 2018 Sep;29(9):2372\u201385. https:\/\/doi.org\/10.1681\/asn.2017121272.","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"7357_CR55","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.7150\/ijbs.64943","volume":"18","author":"T Yu","year":"2022","unstructured":"Yu T, Yao L, Yin H, Teng Y, Hong M, Wu Q. ALKBH5 promotes multiple myeloma tumorigenicity through inducing m(6)A-demethylation of SAV1 mRNA and myeloma stem cell phenotype. Int J Biol Sci. 2022;18(6):2235\u201348. https:\/\/doi.org\/10.7150\/ijbs.64943.","journal-title":"Int J Biol Sci"},{"key":"7357_CR56","doi-asserted-by":"publisher","first-page":"114423","DOI":"10.1016\/j.bcp.2021.114423","volume":"185","author":"S Tan","year":"2021","unstructured":"Tan S, Zhao Z, Qiao Y, et al. Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis. Biochem Pharmacol. 2021 Mar;185:114423. https:\/\/doi.org\/10.1016\/j.bcp.2021.114423.","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"7357_CR57","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.7150\/ijbs.73428","volume":"18","author":"T Liu","year":"2022","unstructured":"Liu T, Guo W, Luo K, et al. Smoke-induced SAV1 gene promoter hypermethylation disrupts YAP negative feedback and promotes malignant progression of non-small cell lung cancer. Int J Biol Sci. 2022;18(11):4497\u2013512. https:\/\/doi.org\/10.7150\/ijbs.73428.","journal-title":"Int J Biol Sci"},{"key":"7357_CR58","doi-asserted-by":"publisher","unstructured":"Sharifi-Sanjani M, Berman M, Goncharov D, et al. Yes-associated protein (YAP) is up-regulated in heart failure and promotes cardiac fibroblast proliferation. Int J Mol Sci. 2021 Jun 7;22(11). https:\/\/doi.org\/10.3390\/ijms22116164.","DOI":"10.3390\/ijms22116164"},{"issue":"6","key":"7357_CR59","doi-asserted-by":"publisher","first-page":"e0131113","DOI":"10.1371\/journal.pone.0131113","volume":"10","author":"BL Aerne","year":"2015","unstructured":"Aerne BL, Gailite I, Sims D, Tapon N. Hippo stabilises its adaptor salvador by antagonising the hect ubiquitin ligase Herc4. PLoS One. 2015;10(6):e0131113. https:\/\/doi.org\/10.1371\/journal.pone.0131113.","journal-title":"PLoS One"},{"issue":"9","key":"7357_CR60","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tcb.2015.05.002","volume":"25","author":"CG Hansen","year":"2015","unstructured":"Hansen CG, Moroishi T, Guan KL. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol. 2015 Sep;25(9):499\u2013513. https:\/\/doi.org\/10.1016\/j.tcb.2015.05.002.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"7357_CR61","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00441-020-03332-4","volume":"384","author":"AE Dillinger","year":"2021","unstructured":"Dillinger AE, Kuespert S, Froemel F, Tamm ER, Fuchshofer R. CCN2\/CTGF promotor activity in the developing and adult mouse eye. Cell Tissue Res. 2021 Jun;384(3):625\u201341. https:\/\/doi.org\/10.1007\/s00441-020-03332-4.","journal-title":"Cell Tissue Res"},{"issue":"3","key":"7357_CR62","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/carcin\/bgad009","volume":"44","author":"F Chen","year":"2023","unstructured":"Chen F, Aye L, Yu L, et al. SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis. Carcinogenesis. 2023 May 27;44(3):232\u201341. https:\/\/doi.org\/10.1093\/carcin\/bgad009.","journal-title":"Carcinogenesis"},{"issue":"6","key":"7357_CR63","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1152\/jn.00627.2024","volume":"133","author":"Q Wang","year":"2025","unstructured":"Wang Q, Aye L, Schumacher JG, et al. Dysregulated angiogenin and related pathways in the ventral midbrain of \u201credhead\u201d mice with MC1R disruption. J Neurophysiol. 2025 Jun 1;133(6):1740\u201348. https:\/\/doi.org\/10.1152\/jn.00627.2024.","journal-title":"J Neurophysiol"},{"key":"7357_CR64","doi-asserted-by":"publisher","unstructured":"Lou S, Zhang R, Xia C, et al. Resveratrol oligomers trans-gnetin H promotes reactive oxygen species generation and rictor degradation to suppress cancer cell viability. ICell. 2025;2(1). https:\/\/doi.org\/10.71373\/UGHK9221.","DOI":"10.71373\/UGHK9221"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07357-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07357-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07357-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:21:41Z","timestamp":1763547701000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07357-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7357"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07357-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"27 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethics Committee of People\u2019s Hospital of Hotan District.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors of this article give their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors state that they do not have any financial interest or other relationships with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which include unlabelled, unapproved, or investigative products or devices.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare that no competing interest exists.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1319"}}