{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:20:34Z","timestamp":1790781634154,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Leading alents Program of Zheiiang Province","award":["2024C03185"],"award-info":[{"award-number":["2024C03185"]}]},{"name":"the National Key R&D Program of China","award":["2023YFC2507100"],"award-info":[{"award-number":["2023YFC2507100"]}]},{"name":"National Nature Fund Youth Fund of China","award":["82400125"],"award-info":[{"award-number":["82400125"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07382-6","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:11:48Z","timestamp":1764072708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u03b2-Nicotinamide mononucleotide activates the SIRT1\/NF-\u03baB pathway to alleviate ischemia reperfusion injury after lung transplantation"],"prefix":"10.1186","volume":"23","author":[{"given":"Ganggui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiong","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqin","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-2254","authenticated-orcid":false,"given":"Man","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"8","key":"7382_CR1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.healun.2022.05.013","volume":"41","author":"M Capuzzimati","year":"2022","unstructured":"Capuzzimati M, Hough O, Liu M. Cell death and ischemia-reperfusion injury in lung transplantation. J Heart Lung Transpl. 2022;41(8):1003\u201313. https:\/\/doi.org\/10.1016\/j.healun.2022.05.013.","journal-title":"J Heart Lung Transpl"},{"key":"7382_CR2","doi-asserted-by":"publisher","unstructured":"Chen-Yoshikawa TF. Ischemia-reperfusion injury in lung transplantation. Cells. 2021;10(6). https:\/\/doi.org\/10.3390\/cells10061333.","DOI":"10.3390\/cells10061333"},{"issue":"1","key":"7382_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.18388\/abp.2017_2312","volume":"65","author":"A Ostrozka-Cieslik","year":"2018","unstructured":"Ostrozka-Cieslik A, Dolinska B, Ryszka F. Tips for optimizing organ preservation solutions. Acta Biochim Pol. 2018;65(1):9\u201315. https:\/\/doi.org\/10.18388\/abp.2017_2312.","journal-title":"Acta Biochim Pol"},{"issue":"4","key":"7382_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S2213-2600(12)70064-4","volume":"1","author":"L Munshi","year":"2013","unstructured":"Munshi L, Keshavjee S, Cypel M. Donor management and lung preservation for lung transplantation. Lancet Respir Med. 2013;1(4):318\u201328. https:\/\/doi.org\/10.1016\/S2213-2600(12)70064-4.","journal-title":"Lancet Respir Med"},{"key":"7382_CR5","doi-asserted-by":"publisher","unstructured":"Wong A, Zamel R, Yeung J, et al. Potential therapeutic targets for lung repair during human ex vivo lung perfusion. Eur Respir J. 2020;55(4). https:\/\/doi.org\/10.1183\/13993003.02222-2019.","DOI":"10.1183\/13993003.02222-2019"},{"issue":"3","key":"7382_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.healun.2013.10.031","volume":"33","author":"W Gao","year":"2014","unstructured":"Gao W, Zhao J, Kim H, et al. alpha1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death. J Heart Lung Transpl. 2014;33(3):309\u201315. https:\/\/doi.org\/10.1016\/j.healun.2013.10.031.","journal-title":"J Heart Lung Transpl"},{"issue":"6","key":"7382_CR7","doi-asserted-by":"publisher","first-page":"L979","DOI":"10.1152\/ajplung.00516.2020","volume":"320","author":"L Jing","year":"2021","unstructured":"Jing L, Konoeda H, Keshavjee S, Liu M. Using nutrient-rich solutions and adding multiple cytoprotective agents as new strategies to develop lung preservation solutions. Am J Physiol Lung Cell Mol Physiol. 2021;320(6):L979\u201389. https:\/\/doi.org\/10.1152\/ajplung.00516.2020.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"7382_CR8","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.advnut.2023.08.008","volume":"14","author":"Q Song","year":"2023","unstructured":"Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update. Adv Nutr. 2023;14(6):1416\u201335. https:\/\/doi.org\/10.1016\/j.advnut.2023.08.008.","journal-title":"Adv Nutr"},{"issue":"10","key":"7382_CR9","doi-asserted-by":"publisher","first-page":"9737","DOI":"10.1007\/s11033-022-07459-1","volume":"49","author":"M Soma","year":"2022","unstructured":"Soma M, Lalam SK. The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. Mol Biol Rep. 2022;49(10):9737\u201348. https:\/\/doi.org\/10.1007\/s11033-022-07459-1.","journal-title":"Mol Biol Rep"},{"issue":"1","key":"7382_CR10","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1038\/s41467-019-13694-1","volume":"10","author":"E Migliavacca","year":"2019","unstructured":"Migliavacca E, Tay SKH, Patel HP, et al. Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities. Nat Commun. 2019;10(1):5808. https:\/\/doi.org\/10.1038\/s41467-019-13694-1.","journal-title":"Nat Commun"},{"issue":"3","key":"7382_CR11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","volume":"27","author":"L Rajman","year":"2018","unstructured":"Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-Boosting molecules: the in vivo evidence. Cell Metab. 2018;27(3):529\u201347. https:\/\/doi.org\/10.1016\/j.cmet.2018.02.011.","journal-title":"Cell Metab"},{"key":"7382_CR12","doi-asserted-by":"publisher","unstructured":"Deng H, Ding D, Ma Y, et al. Nicotinamide mononucleotide: research process in cardiovascular diseases. Int J Mol Sci. 2024;25(17). https:\/\/doi.org\/10.3390\/ijms25179526.","DOI":"10.3390\/ijms25179526"},{"issue":"3","key":"7382_CR13","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","volume":"92","author":"R Nogueiras","year":"2012","unstructured":"Nogueiras R, Habegger KM, Chaudhary N, et al. Sirtuin 1 and Sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012;92(3):1479\u2013514. https:\/\/doi.org\/10.1152\/physrev.00022.2011.","journal-title":"Physiol Rev"},{"key":"7382_CR14","doi-asserted-by":"publisher","first-page":"154365","DOI":"10.1016\/j.phymed.2022.154365","volume":"105","author":"M Hao","year":"2022","unstructured":"Hao M, Ding C, Peng X, et al. Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K\/AKT\/mTOR pathway, SIRT1\/NF-kappaB pathway and intestinal flora. Phytomedicine. 2022;105:154365. https:\/\/doi.org\/10.1016\/j.phymed.2022.154365.","journal-title":"Phytomedicine"},{"key":"7382_CR15","doi-asserted-by":"publisher","first-page":"108568","DOI":"10.1016\/j.jnutbio.2020.108568","volume":"89","author":"G Luo","year":"2021","unstructured":"Luo G, Xiao L, Wang D, et al. Resveratrol attenuates excessive ethanol exposure-induced beta-cell senescence in rats: A critical role for the NAD(+)\/SIRT1-p38MAPK\/p16 pathway. J Nutr Biochem. 2021;89:108568. https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108568.","journal-title":"J Nutr Biochem"},{"key":"7382_CR16","doi-asserted-by":"publisher","unstructured":"Xu C, Dai J, Ai H, Du W, Ji H. beta-Nicotinamide mononucleotide promotes cell proliferation and hair growth by reducing oxidative stress. Molecules. 2024;29(4). https:\/\/doi.org\/10.3390\/molecules29040798.","DOI":"10.3390\/molecules29040798"},{"issue":"5","key":"7382_CR17","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s11357-019-00074-2","volume":"41","author":"T Kiss","year":"2019","unstructured":"Kiss T, Balasubramanian P, Valcarcel-Ares MN, et al. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Geroscience. 2019;41(5):619\u201330. https:\/\/doi.org\/10.1007\/s11357-019-00074-2.","journal-title":"Geroscience"},{"issue":"1","key":"7382_CR18","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41598-017-00851-z","volume":"7","author":"CC Wei","year":"2017","unstructured":"Wei CC, Kong YY, Li GQ, Guan YF, Wang P, Miao CY. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2\/HO-1 signaling pathway. Sci Rep. 2017;7(1):717. https:\/\/doi.org\/10.1038\/s41598-017-00851-z.","journal-title":"Sci Rep"},{"key":"7382_CR19","doi-asserted-by":"publisher","unstructured":"Saren G, Wong A, Lu YB, et al. Ischemia-reperfusion injury in a simulated lung transplant setting differentially regulates transcriptomic profiles between human lung endothelial and epithelial cells. Cells. 2021;10(10). https:\/\/doi.org\/10.3390\/cells10102713.","DOI":"10.3390\/cells10102713"},{"issue":"4","key":"7382_CR20","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1152\/jappl.2000.89.4.1553","volume":"89","author":"JA Cardella","year":"2000","unstructured":"Cardella JA, Keshavjee S, Mourgeon E, et al. A novel cell culture model for studying ischemia-reperfusion injury in lung transplantation. J Appl Physiol (1985). 2000;89(4):1553\u201360. https:\/\/doi.org\/10.1152\/jappl.2000.89.4.1553.","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"7382_CR21","doi-asserted-by":"publisher","first-page":"L78","DOI":"10.1152\/ajplung.00221.2019","volume":"318","author":"K Moskowitzova","year":"2020","unstructured":"Moskowitzova K, Orfany A, Liu K, et al. Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2020;318(1):L78\u201388. https:\/\/doi.org\/10.1152\/ajplung.00221.2019.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"7382_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.molimm.2020.01.017","volume":"120","author":"T Zhan","year":"2020","unstructured":"Zhan T, Wei T, Dong L, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83\u201392. https:\/\/doi.org\/10.1016\/j.molimm.2020.01.017.","journal-title":"Mol Immunol"},{"key":"7382_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fimmu.2020.00235","volume":"11","author":"Z Qin","year":"2020","unstructured":"Qin Z, Wang PY, Wan JJ, et al. MicroRNA124-IL6R mediates the effect of nicotine in inflammatory bowel disease by shifting Th1\/Th2 balance toward Th1. Front Immunol. 2020;11:235. https:\/\/doi.org\/10.3389\/fimmu.2020.00235.","journal-title":"Front Immunol"},{"issue":"1","key":"7382_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12967-024-05024-x","volume":"22","author":"D Bojic","year":"2024","unstructured":"Bojic D, Aujla T, Sugihara J, Wong A, Keshavjee S, Liu M. Thyroid hormone protects human lung epithelial cells from cold preservation and warm reperfusion-induced injury. J Transl Med. 2024;22(1):221. https:\/\/doi.org\/10.1186\/s12967-024-05024-x.","journal-title":"J Transl Med"},{"issue":"10","key":"7382_CR25","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1097\/tp.0000000000004638","volume":"107","author":"J Zhao","year":"2023","unstructured":"Zhao J, Li J, Wei D, et al. Liproxstatin-1 alleviates lung Transplantation-induced cold Ischemia-Reperfusion injury by inhibiting ferroptosis. Transplantation. 2023;107(10):2190\u2013202. https:\/\/doi.org\/10.1097\/tp.0000000000004638. (In eng).","journal-title":"Transplantation"},{"issue":"5","key":"7382_CR26","doi-asserted-by":"publisher","first-page":"e0126952","DOI":"10.1371\/journal.pone.0126952","volume":"10","author":"L Zhang","year":"2015","unstructured":"Zhang L, Li M, Zhan L, et al. Plasma metabolomic profiling of patients with diabetes-associated cognitive decline. PLoS ONE. 2015;10(5):e0126952. https:\/\/doi.org\/10.1371\/journal.pone.0126952.","journal-title":"PLoS ONE"},{"key":"7382_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.aca.2019.03.012","volume":"1063","author":"C Li","year":"2019","unstructured":"Li C, Zhang J, Wu R, et al. A novel strategy for rapidly and accurately screening biomarkers based on ultraperformance liquid chromatography-mass spectrometry metabolomics data. Anal Chim Acta. 2019;1063:47\u201356. https:\/\/doi.org\/10.1016\/j.aca.2019.03.012.","journal-title":"Anal Chim Acta"},{"issue":"1","key":"7382_CR28","doi-asserted-by":"publisher","first-page":"13660","DOI":"10.1038\/s41598-020-70520-1","volume":"10","author":"J Pan","year":"2020","unstructured":"Pan J, Li Z, Dai S, et al. Integrative analyses of transcriptomics and metabolomics upon seed germination of Foxtail millet in response to salinity. Sci Rep. 2020;10(1):13660. https:\/\/doi.org\/10.1038\/s41598-020-70520-1.","journal-title":"Sci Rep"},{"issue":"1","key":"7382_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/10715762.2020.1863393","volume":"55","author":"F Yang","year":"2021","unstructured":"Yang F, Yan J, Lu Y, Wang D, Liu L, Wang Z. MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury. Free Radic Res. 2021;55(1):71\u201382. https:\/\/doi.org\/10.1080\/10715762.2020.1863393.","journal-title":"Free Radic Res"},{"key":"7382_CR30","doi-asserted-by":"publisher","first-page":"102745","DOI":"10.1016\/j.redox.2023.102745","volume":"63","author":"HR Li","year":"2023","unstructured":"Li HR, Liu Q, Zhu CL, et al. beta-Nicotinamide mononucleotide activates NAD+\/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox Biol. 2023;63:102745. https:\/\/doi.org\/10.1016\/j.redox.2023.102745.","journal-title":"Redox Biol"},{"issue":"1","key":"7382_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1080\/13880209.2023.2292256","volume":"62","author":"S He","year":"2024","unstructured":"He S, Jiang X, Yang J, et al. Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1\/NF-kappaB pathway. Pharm Biol. 2024;62(1):22\u201332. https:\/\/doi.org\/10.1080\/13880209.2023.2292256.","journal-title":"Pharm Biol"},{"key":"7382_CR32","doi-asserted-by":"publisher","first-page":"702107","DOI":"10.3389\/fmolb.2021.702107","volume":"8","author":"J Liu","year":"2021","unstructured":"Liu J, Zong Z, Zhang W, et al. Nicotinamide mononucleotide alleviates LPS-Induced inflammation and oxidative stress via decreasing COX-2 expression in macrophages. Front Mol Biosci. 2021;8:702107. https:\/\/doi.org\/10.3389\/fmolb.2021.702107.","journal-title":"Front Mol Biosci"},{"key":"7382_CR33","doi-asserted-by":"publisher","unstructured":"Ehrsam JP, Chen J, Rodriguez Cetina Biefer H, Opitz I, Arni S, Inci I. Ex vivo lung perfusion with beta-Nicotinamide adenine dinucleotide (NAD(+)) improves ischemic lung function. Antioxid (Basel). 2022;11(5). https:\/\/doi.org\/10.3390\/antiox11050843.","DOI":"10.3390\/antiox11050843"},{"issue":"1","key":"7382_CR34","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12931-024-02776-4","volume":"25","author":"HQ Ta","year":"2024","unstructured":"Ta HQ, Kuppusamy M, Sonkusare SK, Roeser ME, Laubach VE. The endothelium: gatekeeper to lung ischemia-reperfusion injury. Respir Res. 2024;25(1):172. https:\/\/doi.org\/10.1186\/s12931-024-02776-4.","journal-title":"Respir Res"},{"key":"7382_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03748-7","author":"MA Bejeshk","year":"2025","unstructured":"Bejeshk MA, Najafipour H, Khaksari M, et al. Myrtenol-loaded niosomes can prevent lung ischemia-reperfusion injury model in rats by balancing the Nrf2\/Keap1 and NF-kappaB signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2025. https:\/\/doi.org\/10.1007\/s00210-024-03748-7.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"8","key":"7382_CR36","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s10157-021-02057-0","volume":"25","author":"A Raji-Amirhasani","year":"2021","unstructured":"Raji-Amirhasani A, Khaksari M, Darvishzadeh Mahani F, Hajializadeh Z. Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury). Clin Exp Nephrol. 2021;25(8):807\u201321. https:\/\/doi.org\/10.1007\/s10157-021-02057-0.","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"7382_CR37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13020-025-01166-2","volume":"20","author":"M Xu","year":"2025","unstructured":"Xu M, Sun X, Ma X, et al. Sodium Tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1. Chin Med. 2025;20(1):142. https:\/\/doi.org\/10.1186\/s13020-025-01166-2. (In eng).","journal-title":"Chin Med"},{"issue":"8","key":"7382_CR38","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.it.2023.05.007","volume":"44","author":"J Huyghe","year":"2023","unstructured":"Huyghe J, Priem D, Bertrand MJM. Cell death checkpoints in the TNF pathway. Trends Immunol. 2023;44(8):628\u201343. https:\/\/doi.org\/10.1016\/j.it.2023.05.007.","journal-title":"Trends Immunol"},{"key":"7382_CR39","doi-asserted-by":"publisher","first-page":"103231","DOI":"10.1016\/j.redox.2024.103231","volume":"74","author":"J Yu","year":"2024","unstructured":"Yu J, Fu Y, Gao J, et al. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury. Redox Biol. 2024;74:103231. https:\/\/doi.org\/10.1016\/j.redox.2024.103231. (In eng).","journal-title":"Redox Biol"},{"issue":"12suppl","key":"7382_CR40","doi-asserted-by":"publisher","first-page":"S593","DOI":"10.1177\/09603271211043480","volume":"40","author":"L Jia","year":"2021","unstructured":"Jia L, Cui W, Chen J, et al. Erythropoietin alleviates acute lung injury induced by ischemia-reperfusion through blocking p38 MAPK signaling. Hum Exp Toxicol. 2021;40(12suppl):S593\u2013602. https:\/\/doi.org\/10.1177\/09603271211043480. (In eng).","journal-title":"Hum Exp Toxicol"},{"issue":"8","key":"7382_CR41","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.healun.2013.05.005","volume":"32","author":"J Tan","year":"2013","unstructured":"Tan J, Liu D, Lv X, et al. MAPK mediates inflammatory response and cell death in rat pulmonary microvascular endothelial cells in an ischemia-reperfusion model of lung transplantation. J Heart Lung Transpl. 2013;32(8):823\u201331. https:\/\/doi.org\/10.1016\/j.healun.2013.05.005. (In eng).","journal-title":"J Heart Lung Transpl"},{"issue":"2","key":"7382_CR42","doi-asserted-by":"publisher","first-page":"926","DOI":"10.3892\/ijmm.2018.3674","volume":"42","author":"Z Yang","year":"2018","unstructured":"Yang Z, Zhang XR, Zhao Q, et al. Knockdown of TNF\u2013\u03b1 alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL\u201310 expression. Int J Mol Med. 2018;42(2):926\u201334. https:\/\/doi.org\/10.3892\/ijmm.2018.3674. (In eng).","journal-title":"Int J Mol Med"},{"key":"7382_CR43","doi-asserted-by":"publisher","unstructured":"Wang H, Sun Y, Pi C, et al. Nicotinamide mononucleotide supplementation improves mitochondrial dysfunction and rescues cellular senescence by NAD(+)\/Sirt3 pathway in mesenchymal stem cells. Int J Mol Sci. 2022;23(23). https:\/\/doi.org\/10.3390\/ijms232314739.","DOI":"10.3390\/ijms232314739"},{"key":"7382_CR44","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.freeradbiomed.2020.11.014","volume":"162","author":"Z Zong","year":"2021","unstructured":"Zong Z, Liu J, Wang N, et al. Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE(2) degradation. Free Radic Biol Med. 2021;162:571\u201381. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.11.014. (In eng).","journal-title":"Free Radic Biol Med"},{"key":"7382_CR45","doi-asserted-by":"publisher","unstructured":"Wang L, Zhao M, Qian R, et al. Nicotinamide mononucleotide ameliorates silica-induced lung injury through the Nrf2-regulated glutathione metabolism pathway in mice. Nutrients. 2022;15(1). https:\/\/doi.org\/10.3390\/nu15010143. (In eng).","DOI":"10.3390\/nu15010143"},{"issue":"11","key":"7382_CR46","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1177\/0960327115626254","volume":"35","author":"DB Conze","year":"2016","unstructured":"Conze DB, Crespo-Barreto J, Kruger CL. Safety assessment of nicotinamide riboside, a form of vitamin B(3). Hum Exp Toxicol. 2016;35(11):1149\u201360. https:\/\/doi.org\/10.1177\/0960327115626254. (In eng).","journal-title":"Hum Exp Toxicol"},{"issue":"6","key":"7382_CR47","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1681\/asn.2020081188","volume":"32","author":"I Yasuda","year":"2021","unstructured":"Yasuda I, Hasegawa K, Sakamaki Y, et al. Pre-emptive Short-term nicotinamide mononucleotide treatment in a mouse model of diabetic nephropathy. J Am Soc Nephrol. 2021;32(6):1355\u201370. https:\/\/doi.org\/10.1681\/asn.2020081188. (In eng).","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"7382_CR48","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12931-017-0557-2","volume":"18","author":"GC Wu","year":"2017","unstructured":"Wu GC, Liao WI, Wu SY, et al. Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia\/reperfusion in rats. Respir Res. 2017;18(1):71. https:\/\/doi.org\/10.1186\/s12931-017-0557-2.","journal-title":"Respir Res"},{"issue":"2","key":"7382_CR49","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/ana.22236","volume":"69","author":"P Wang","year":"2011","unstructured":"Wang P, Xu TY, Guan YF, et al. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol. 2011;69(2):360\u201374. https:\/\/doi.org\/10.1002\/ana.22236.","journal-title":"Ann Neurol"},{"issue":"7","key":"7382_CR50","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.7150\/thno.94482","volume":"14","author":"Y Chen","year":"2024","unstructured":"Chen Y, Wang T, Liang F, et al. Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice. Theranostics. 2024;14(7):2794\u2013815. https:\/\/doi.org\/10.7150\/thno.94482.","journal-title":"Theranostics"},{"key":"7382_CR51","doi-asserted-by":"publisher","unstructured":"Dong L, Liang F, Lou Z, et al. Necrostatin-1 alleviates lung ischemia-reperfusion injury via inhibiting necroptosis and apoptosis of lung epithelial cells. Cells. 2022;11(19). https:\/\/doi.org\/10.3390\/cells11193139.","DOI":"10.3390\/cells11193139"},{"issue":"1","key":"7382_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12931-025-03151-7","volume":"26","author":"X Gao","year":"2025","unstructured":"Gao X, Tang M, Li J, Ma J, Liu Z, Liu W. Activation of Nrf2 pathway by 4-Octyl Itaconate enhances donor lung function in cold preservation settings. Respir Res. 2025;26(1):69. https:\/\/doi.org\/10.1186\/s12931-025-03151-7.","journal-title":"Respir Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07382-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07382-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07382-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:11:49Z","timestamp":1764072709000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-07382-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7382"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07382-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"11 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Experimental Animal Ethics Committee at the Second Affiliated Hospital of Zhejiang University approved the animal experiments (AIRB-2024-125).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None relevant to the content of this paper to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1349"}}