{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:01:22Z","timestamp":1793746882937,"version":"4.6.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Guangxi Key Research and Development Project","award":["No.AB24010149"],"award-info":[{"award-number":["No.AB24010149"]}]},{"name":"The Guangxi Clinical Research Center for Enhanced Recovery after Surgery, Guangxi Science and Technology Base and Talent Project","award":["No.AD19245196"],"award-info":[{"award-number":["No.AD19245196"]}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["No.YCBZ2025110"],"award-info":[{"award-number":["No.YCBZ2025110"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07463-6","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:16:11Z","timestamp":1763806571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression"],"prefix":"10.1186","volume":"24","author":[{"given":"Jian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantian","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-3537","authenticated-orcid":false,"given":"Junqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"issue":"3","key":"7463_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"7463_CR2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","volume":"39","author":"RE Sexton","year":"2020","unstructured":"Sexton RE, Al Hallak MN, Diab M, et al. Gastric cancer: a comprehensive review of current and future treatment strategies. Cancer Metastasis Rev. 2020;39(4):1179\u2013203.","journal-title":"Cancer Metastasis Rev"},{"issue":"7","key":"7463_CR3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.trecan.2024.03.008","volume":"10","author":"T Yasuda","year":"2024","unstructured":"Yasuda T, Wang YA. Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development. Trends Cancer. 2024;10(7):627\u201342.","journal-title":"Trends Cancer"},{"issue":"4","key":"7463_CR4","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.7150\/ijbs.56735","volume":"17","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhang L, Yang Y, et al. Progress of gastric cancer surgery in the era of precision medicine. Int J Biol Sci. 2021;17(4):1041\u20139.","journal-title":"Int J Biol Sci"},{"key":"7463_CR5","doi-asserted-by":"crossref","unstructured":"Del D\u00edaz C, Fern\u00e1ndez Ace\u00f1ero MJ, Ortega Medina L. Molecular classifications in gastric cancer: a call for interdisciplinary collaboration. Int J Mol Sci. 2024;25(5).","DOI":"10.3390\/ijms25052649"},{"issue":"14","key":"7463_CR6","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1158\/1078-0432.CCR-19-3018","volume":"26","author":"G Galletti","year":"2020","unstructured":"Galletti G, Zhang C, Gjyrezi A, et al. Microtubule engagement with taxane is altered in taxane-Resistant gastric cancer. Clin Cancer Research: Official J Am Association Cancer Res. 2020;26(14):3771\u201383.","journal-title":"Clin Cancer Research: Official J Am Association Cancer Res"},{"issue":"10251","key":"7463_CR7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer. Lancet. 2020;396(10251):635\u201348.","journal-title":"Lancet"},{"issue":"10","key":"7463_CR8","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","volume":"33","author":"F Lordick","year":"2022","unstructured":"Lordick F, Carneiro F, Cascinu S, et al. Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Annals Oncology: Official J Eur Soc Med Oncol. 2022;33(10):1005\u201320.","journal-title":"Annals Oncology: Official J Eur Soc Med Oncol"},{"key":"7463_CR9","doi-asserted-by":"crossref","unstructured":"Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression. Science. 2020;368(6487).","DOI":"10.1126\/science.aaw5473"},{"issue":"3","key":"7463_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","volume":"41","author":"MV Liberti","year":"2016","unstructured":"Liberti MV, Locasale JW. The Warburg effect: how does it benefit cancer cells?. Trends Biochem Sci. 2016;41(3):211\u20138.","journal-title":"Trends Biochem Sci"},{"key":"7463_CR11","doi-asserted-by":"crossref","unstructured":"Liao M, Yao D, Wu L, et al. Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer. Acta Pharm Sin B. 2024;14(3).","DOI":"10.1016\/j.apsb.2023.12.003"},{"issue":"1","key":"7463_CR12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-020-01629-4","volume":"39","author":"J Feng","year":"2020","unstructured":"Feng J, Li J, Wu L, et al. Emerging roles and the regulation of aerobic Glycolysis in hepatocellular carcinoma. J Experimental Clin Cancer Research: CR. 2020;39(1):126.","journal-title":"J Experimental Clin Cancer Research: CR"},{"issue":"1","key":"7463_CR13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13045-022-01358-5","volume":"15","author":"X Zhong","year":"2022","unstructured":"Zhong X, He X, Wang Y, et al. Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications. J Hematol Oncol. 2022;15(1):160.","journal-title":"J Hematol Oncol"},{"issue":"2","key":"7463_CR14","first-page":"861","volume":"12","author":"X Chang","year":"2022","unstructured":"Chang X, Liu X, Wang H, et al. Glycolysis in the progression of pancreatic cancer. Am J Cancer Res. 2022;12(2):861\u201372.","journal-title":"Am J Cancer Res"},{"key":"7463_CR15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.canlet.2020.11.018","volume":"503","author":"S Zhu","year":"2021","unstructured":"Zhu S, Guo Y, Zhang X, et al. Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. Cancer Lett. 2021;503:240\u20138.","journal-title":"Cancer Lett"},{"issue":"4","key":"7463_CR16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2012.07.018","volume":"150","author":"W Yang","year":"2012","unstructured":"Yang W, Xia Y, Hawke D, et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell. 2012;150(4):685\u201396.","journal-title":"Cell"},{"key":"7463_CR17","doi-asserted-by":"crossref","unstructured":"Wu B, Liang Z, Lan H, et al. The role of PKM2 in cancer progression and its structural and biological basis. J Physiol Biochem. 2024.","DOI":"10.1007\/s13105-024-01007-0"},{"issue":"1","key":"7463_CR18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41421-023-00633-0","volume":"10","author":"L-J Liang","year":"2024","unstructured":"Liang L-J, Yang F-Y, Wang D, et al. CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer. Cell Discov. 2024;10(1):13.","journal-title":"Cell Discov"},{"issue":"2","key":"7463_CR19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s13105-024-01007-0","volume":"80","author":"B Wu","year":"2024","unstructured":"Wu B, Liang Z, Lan H, et al. The role of PKM2 in cancer progression and its structural and biological basis. J Physiol Biochem. 2024;80(2):261\u201375.","journal-title":"J Physiol Biochem"},{"issue":"5","key":"7463_CR20","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.molcel.2014.02.015","volume":"53","author":"KE Keller","year":"2014","unstructured":"Keller KE, Doctor ZM, Dwyer ZW, et al. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Mol Cell. 2014;53(5):700\u20139.","journal-title":"Mol Cell"},{"issue":"2","key":"7463_CR21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbcan.2019.02.003","volume":"1871","author":"S Amin","year":"2019","unstructured":"Amin S, Yang P, Li Z. Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression. Biochim Et Biophys Acta Reviews Cancer. 2019;1871(2):331\u201341.","journal-title":"Biochim Et Biophys Acta Reviews Cancer"},{"issue":"1","key":"7463_CR22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41392-022-01096-7","volume":"7","author":"G Zhao","year":"2022","unstructured":"Zhao G, Yuan H, Li Q, et al. DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2. Signal Transduct Target Ther. 2022;7(1):275.","journal-title":"Signal Transduct Target Ther"},{"key":"7463_CR23","doi-asserted-by":"crossref","first-page":"111920","DOI":"10.1016\/j.bios.2019.111920","volume":"150","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Bracken H, Woolhead C, et al. Functionalisation of human chloride intracellular ion channels in microfluidic droplet-interface-bilayers. Biosens Bioelectron. 2020;150:111920.","journal-title":"Biosens Bioelectron"},{"issue":"1","key":"7463_CR24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00249-009-0450-0","volume":"39","author":"SC Goodchild","year":"2009","unstructured":"Goodchild SC, Howell MW, Cordina NM, et al. Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane. Eur Biophys J. 2009;39(1):129\u201338.","journal-title":"Eur Biophys J"},{"key":"7463_CR25","doi-asserted-by":"crossref","first-page":"101560","DOI":"10.1016\/j.tranon.2022.101560","volume":"27","author":"H Geng","year":"2023","unstructured":"Geng H, Feng C, Sun Z, et al. Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling. Transl Oncol. 2023;27:101560.","journal-title":"Transl Oncol"},{"key":"7463_CR26","doi-asserted-by":"crossref","unstructured":"Peng J-M, Lin S-H, Yu M-C, et al. CLIC1 recruits PIP5K1A\/C to induce cell-matrix adhesions for tumor metastasis. J Clin Investig. 2021;131(1).","DOI":"10.1172\/JCI133525"},{"issue":"1","key":"7463_CR27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canlet.2009.02.020","volume":"281","author":"J-W Wang","year":"2009","unstructured":"Wang J-W, Peng S-Y, Li J-T, et al. Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1. Cancer Lett. 2009;281(1):71\u201381.","journal-title":"Cancer Lett"},{"issue":"6","key":"7463_CR28","first-page":"616","volume":"32","author":"J Lu","year":"2015","unstructured":"Lu J, Dong Q, Zhang B, et al. Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer. Med Oncol. 2015;32(6):616.","journal-title":"Med Oncol"},{"key":"7463_CR29","first-page":"247","volume":"14","author":"J Xia","year":"2022","unstructured":"Xia J, Wang Q, Ju F, et al. Chloride intracellular channel 1 is a potential biomarker for breast cancer. Breast Cancer (Dove Med Press). 2022;14:247\u201358.","journal-title":"Breast Cancer (Dove Med Press)"},{"issue":"24","key":"7463_CR30","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.3748\/wjg.v18.i24.3070","volume":"18","author":"P-F Ma","year":"2012","unstructured":"Ma P-F, Chen J-Q, Wang Z, et al. Function of chloride intracellular channel 1 in gastric cancer cells. World J Gastroenterol. 2012;18(24):3070\u201380.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"7463_CR31","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s12094-020-02445-0","volume":"23","author":"Y Qiu","year":"2021","unstructured":"Qiu Y, Mao YT, Zhu JH, et al. CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression. Clin Transl Oncol. 2021;23(3):514\u201325.","journal-title":"Clin Transl Oncol"},{"issue":"3","key":"7463_CR32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41419-021-04446-5","volume":"13","author":"B Li","year":"2022","unstructured":"Li B, Chen Y, Liang L, et al. Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1\/miR-556-3p\/CLIC1 axis. Cell Death Dis. 2022;13(3):217.","journal-title":"Cell Death Dis"},{"key":"7463_CR33","doi-asserted-by":"crossref","first-page":"108918","DOI":"10.1016\/j.intimp.2022.108918","volume":"111","author":"B Li","year":"2022","unstructured":"Li B, Liang L, Chen Y, et al. Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent Inhibition of CLIC1. Int Immunopharmacol. 2022;111:108918.","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"7463_CR34","doi-asserted-by":"crossref","first-page":"114633","DOI":"10.1016\/j.celrep.2024.114633","volume":"43","author":"J-H Zheng","year":"2024","unstructured":"Zheng J-H, Zhu Y-H, Yang J, et al. A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer. Cell Rep. 2024;43(8):114633.","journal-title":"Cell Rep"},{"issue":"1","key":"7463_CR35","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1186\/s12885-023-11550-6","volume":"23","author":"Y-Y Chen","year":"2023","unstructured":"Chen Y-Y, Li B-P, Wang J-F, et al. Investigating the prognostic and predictive value of the type II Cystatin genes in gastric cancer. BMC Cancer. 2023;23(1):1122.","journal-title":"BMC Cancer"},{"key":"7463_CR36","doi-asserted-by":"crossref","unstructured":"Dai S, Peng Y, Zhu Y, et al. Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine. Biomed Pharmacother. 2020;121:109521.","DOI":"10.1016\/j.biopha.2019.109521"},{"key":"7463_CR37","doi-asserted-by":"crossref","first-page":"1200538","DOI":"10.3389\/fphar.2023.1200538","volume":"14","author":"K Wang","year":"2023","unstructured":"Wang K, Lu H, Wang X, et al. Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC. Front Pharmacol. 2023;14:1200538.","journal-title":"Front Pharmacol"},{"issue":"1","key":"7463_CR38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1165\/rcmb.2022-0111OC","volume":"68","author":"MM Alzaydi","year":"2023","unstructured":"Alzaydi MM, Abdul-Salam VB, Whitwell HJ, et al. Intracellular chloride channels regulate endothelial metabolic reprogramming in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2023;68(1):103\u201315.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"7463_CR39","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s13402-020-00582-w","volume":"44","author":"W Wang","year":"2021","unstructured":"Wang W, Li X, Xu Y, et al. Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-\u03baB. Cell Oncol (Dordrecht). 2021;44(3):557\u201368.","journal-title":"Cell Oncol (Dordrecht)"},{"issue":"2","key":"7463_CR40","first-page":"294","volume":"64","author":"L Qu","year":"2022","unstructured":"Qu L, Liu B, Bi X, et al. CLIC1 promotes the progression of cervical cancer through the PTEN\/PI3K\/AKT pathway. Panminerva Med. 2022;64(2):294\u20135.","journal-title":"Panminerva Med"},{"issue":"8","key":"7463_CR41","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3748\/wjg.v20.i8.2071","volume":"20","author":"P Wang","year":"2014","unstructured":"Wang P, Zeng Y, Liu T, et al. Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS\/ERK pathway. World J Gastroenterol. 2014;20(8):2071\u20138.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"7463_CR42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/15384101.2022.2112132","volume":"22","author":"D Li","year":"2023","unstructured":"Li D, Shen Y, Ren H, et al. Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p\/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer. Cell Cycle (Georgetown Tex). 2023;22(2):255\u201368.","journal-title":"Cell Cycle (Georgetown Tex)"},{"key":"7463_CR43","doi-asserted-by":"crossref","unstructured":"Zhao K, Wang Z, Li X, et al. Exosome-mediated transfer of CLIC1 contributes to the vincristine-resistance in gastric cancer. Mol Cell Biochem. 2019;462(1\u20132).","DOI":"10.1007\/s11010-019-03613-9"},{"key":"7463_CR44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s42003-019-0343-4","volume":"2","author":"T-J Chen","year":"2019","unstructured":"Chen T-J, Wang H-J, Liu J-S, et al. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun Biol. 2019;2:105.","journal-title":"Commun Biol"},{"issue":"1","key":"7463_CR45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12929-025-01170-6","volume":"32","author":"T-J Chen","year":"2025","unstructured":"Chen T-J, Wu C-H, Hung M-C, et al. Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator. J Biomed Sci. 2025;32(1):75.","journal-title":"J Biomed Sci"},{"issue":"7","key":"7463_CR46","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cac2.12158","volume":"41","author":"J-Z Wang","year":"2021","unstructured":"Wang J-Z, Zhu W, Han J, et al. The role of the HIF-1\u03b1\/ALYREF\/PKM2 axis in Glycolysis and tumorigenesis of bladder cancer. Cancer Commun (Lond). 2021;41(7):560\u201375.","journal-title":"Cancer Commun (Lond)"},{"key":"7463_CR47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fonc.2020.00159","volume":"10","author":"K Zahra","year":"2020","unstructured":"Zahra K, Dey T, Ashish, et al. Pyruvate kinase M2 and cancer: the role of PKM2 in promoting tumorigenesis. Front Oncol. 2020;10:159.","journal-title":"Front Oncol"},{"issue":"10","key":"7463_CR48","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nchembio.1060","volume":"8","author":"D Anastasiou","year":"2012","unstructured":"Anastasiou D, Yu Y, Israelsen WJ, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012;8(10):839\u201347.","journal-title":"Nat Chem Biol"},{"issue":"1","key":"7463_CR49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1073\/pnas.1311249111","volume":"111","author":"H-J Wang","year":"2013","unstructured":"Wang H-J, Hsieh Y-J, Cheng W-C, et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1\u03b1-mediated glucose metabolism. Proc Natl Acad Sci USA. 2013;111(1):279\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"7463_CR50","doi-asserted-by":"crossref","first-page":"676","DOI":"10.7150\/thno.30224","volume":"9","author":"M Chen","year":"2019","unstructured":"Chen M, Sheng X-J, Qin Y-Y, et al. TBC1D8 amplification drives tumorigenesis through metabolism reprogramming in ovarian cancer. Theranostics. 2019;9(3):676\u201390.","journal-title":"Theranostics"},{"issue":"12","key":"7463_CR51","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ncb2629","volume":"14","author":"W Yang","year":"2012","unstructured":"Yang W, Zheng Y, Xia Y, et al. ERK1\/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012;14(12):1295\u2013304.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"7463_CR52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-022-01304-4","volume":"8","author":"L Yang","year":"2023","unstructured":"Yang L, Li A, Wang Y, et al. Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy. Signal Transduct Target Ther. 2023;8(1):35.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"7463_CR53","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1158\/0008-5472.CAN-24-2580","volume":"85","author":"T Zhang","year":"2025","unstructured":"Zhang T, Li Y, Zhai E, et al. Intratumoral Fusobacterium nucleatum recruits Tumor-Associated neutrophils to promote gastric cancer progression and immune evasion. Cancer Res. 2025;85(10):1819\u201341.","journal-title":"Cancer Res"},{"issue":"1","key":"7463_CR54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s40168-024-01907-9","volume":"12","author":"J Zhou","year":"2024","unstructured":"Zhou J, Hu Z, Wang L, et al. Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome. 2024;12(1):193.","journal-title":"Microbiome"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07463-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T19:02:14Z","timestamp":1767466934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07463-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7463"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07463-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1"}}