{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:56:20Z","timestamp":1790445380259,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203935"],"award-info":[{"award-number":["82203935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J01745"],"award-info":[{"award-number":["2022J01745"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018541","name":"Science Fund for Distinguished Young Scholars of Jiangsu Province","doi-asserted-by":"publisher","award":["2022XH027"],"award-info":[{"award-number":["2022XH027"]}],"id":[{"id":"10.13039\/501100018541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020754","name":"Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China","doi-asserted-by":"publisher","award":["2023Y9195"],"award-info":[{"award-number":["2023Y9195"]}],"id":[{"id":"10.13039\/100020754","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Startup Fund for scientific research,Fujian Medical University","award":["2023QH1022"],"award-info":[{"award-number":["2023QH1022"]}]},{"name":"The investigator initiation Fund project of Fujian Medical University Union Hospital","award":["2023XH012"],"award-info":[{"award-number":["2023XH012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07491-2","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:34:43Z","timestamp":1764236083000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single-cell and spatial transcriptomics reveal TNC-positive cancer-associated fibroblasts that mediate immunosuppression and promote tumor progression in basal cell carcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Min","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwei","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinger","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-7095","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"issue":"2","key":"7491_CR1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jaad.2021.03.109","volume":"85","author":"P Aggarwal","year":"2021","unstructured":"Aggarwal P, Knabel P, Fleischer AB. United States burden of melanoma and non-melanoma skin cancer from 1990 to 2019. J Am Acad Dermatol. 2021;85(2):388\u201395.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"7491_CR2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/bjd.19809","volume":"185","author":"J Thomson","year":"2021","unstructured":"Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ. Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments. Br J Dermatol. 2021;185(3):499\u2013511.","journal-title":"Br J Dermatol"},{"issue":"8","key":"7491_CR3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/jdv.18048","volume":"36","author":"PN Lacerda","year":"2022","unstructured":"Lacerda PN, Lange EP, Luna NM, Miot HA, Nogueira VSN, Abbade LPF. Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta-analysis. J Eur Acad Dermatology Venereology: JEADV. 2022;36(8):1178\u201390.","journal-title":"J Eur Acad Dermatology Venereology: JEADV"},{"issue":"2","key":"7491_CR4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jaad.2018.03.060","volume":"80","author":"MC Cameron","year":"2019","unstructured":"Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, et al. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol. 2019;80(2):303\u201317.","journal-title":"J Am Acad Dermatol"},{"key":"7491_CR5","doi-asserted-by":"crossref","unstructured":"Ascierto PA, Schadendorf D. Update in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma. J Immunother Cancer. 2022;10(12).","DOI":"10.1136\/jitc-2022-005082"},{"key":"7491_CR6","doi-asserted-by":"crossref","first-page":"113254","DOI":"10.1016\/j.ejca.2023.113254","volume":"192","author":"K Peris","year":"2023","unstructured":"Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, et al. European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer. 2023;192:113254.","journal-title":"Eur J Cancer"},{"issue":"5","key":"7491_CR7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s40257-024-00870-3","volume":"25","author":"AS Farberg","year":"2024","unstructured":"Farberg AS, Portela D, Sharma D, Kheterpal M. Evaluation of the tolerability of Hedgehog pathway inhibitors in the treatment of advanced basal cell carcinoma: A narrative review of treatment strategies. Am J Clin Dermatol. 2024;25(5):779\u201394.","journal-title":"Am J Clin Dermatol"},{"issue":"6","key":"7491_CR8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S1470-2045(21)00126-1","volume":"22","author":"AJ Stratigos","year":"2021","unstructured":"Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, et al. Cemiplimab in locally advanced basal cell carcinoma after Hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial. Lancet Oncol. 2021;22(6):848\u201357.","journal-title":"Lancet Oncol"},{"issue":"728","key":"7491_CR9","doi-asserted-by":"crossref","first-page":"eadg3840","DOI":"10.1126\/scitranslmed.adg3840","volume":"16","author":"JJF Sleeboom","year":"2024","unstructured":"Sleeboom JJF, van Tienderen GS, Schenke-Layland K, van der Laan LJW, Khalil AA, Verstegen MMA. The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets. Sci Transl Med. 2024;16(728):eadg3840.","journal-title":"Sci Transl Med"},{"issue":"1","key":"7491_CR10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12943-023-01860-5","volume":"22","author":"H Zhang","year":"2023","unstructured":"Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N, et al. Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials. Mol Cancer. 2023;22(1):159.","journal-title":"Mol Cancer"},{"issue":"5","key":"7491_CR11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/bjd\/ljae258","volume":"191","author":"M Esposito","year":"2024","unstructured":"Esposito M, Yerly L, Shukla P, Hermes V, Sella F, Balazs Z, et al. COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma. Br J Dermatol. 2024;191(5):775\u201390.","journal-title":"Br J Dermatol"},{"issue":"2","key":"7491_CR12","doi-asserted-by":"crossref","first-page":"e2313326120","DOI":"10.1073\/pnas.2313326120","volume":"121","author":"C Ganier","year":"2024","unstructured":"Ganier C, Mazin P, Herrera-Oropeza G, Du-Harpur X, Blakeley M, Gabriel J, et al. Multiscale Spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma. Proc Natl Acad Sci U S A. 2024;121(2):e2313326120.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"7491_CR13","doi-asserted-by":"crossref","first-page":"eabm7981","DOI":"10.1126\/sciadv.abm7981","volume":"8","author":"CF Guerrero-Juarez","year":"2022","unstructured":"Guerrero-Juarez CF, Lee GH, Liu Y, Wang S, Karikomi M, Sha Y, et al. Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment. Sci Adv. 2022;8(23):eabm7981.","journal-title":"Sci Adv"},{"issue":"1","key":"7491_CR14","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1038\/s41467-022-32670-w","volume":"13","author":"L Yerly","year":"2022","unstructured":"Yerly L, Pich-Bavastro C, Di Domizio J, Wyss T, Tissot-Renaud S, Cangkrama M, et al. Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma. Nat Commun. 2022;13(1):4897.","journal-title":"Nat Commun"},{"issue":"8","key":"7491_CR15","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41587-022-01233-1","volume":"40","author":"R Wei","year":"2022","unstructured":"Wei R, He S, Bai S, Sei E, Hu M, Thompson A, et al. Spatial charting of single-cell transcriptomes in tissues. Nat Biotechnol. 2022;40(8):1190\u20139.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"7491_CR16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411\u201320.","journal-title":"Nat Biotechnol"},{"issue":"12","key":"7491_CR17","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, et al. Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods. 2019;16(12):1289\u201396.","journal-title":"Nat Methods"},{"issue":"10","key":"7491_CR18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA, et al. Reversed graph embedding resolves complex single-cell trajectories. Nat Methods. 2017;14(10):979\u201382.","journal-title":"Nat Methods"},{"issue":"11","key":"7491_CR19","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar S, Gonz\u00e1lez-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, et al. SCENIC: single-cell regulatory network inference and clustering. Nat Methods. 2017;14(11):1083\u20136.","journal-title":"Nat Methods"},{"issue":"1","key":"7491_CR20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan C-H, et al. Inference and analysis of cell-cell communication using cellchat. Nat Commun. 2021;12(1):1088.","journal-title":"Nat Commun"},{"issue":"9","key":"7491_CR21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.ccell.2024.08.011","volume":"42","author":"L Cords","year":"2024","unstructured":"Cords L, de Souza N, Bodenmiller B. Classifying cancer-associated fibroblasts-The good, the bad, and the target. Cancer Cell. 2024;42(9):1480\u20135.","journal-title":"Cancer Cell"},{"key":"7491_CR22","doi-asserted-by":"crossref","first-page":"114504","DOI":"10.1016\/j.addr.2022.114504","volume":"189","author":"R Rimal","year":"2022","unstructured":"Rimal R, Desai P, Daware R, Hosseinnejad A, Prakash J, Lammers T, et al. Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting. Adv Drug Deliv Rev. 2022;189:114504.","journal-title":"Adv Drug Deliv Rev"},{"issue":"7","key":"7491_CR23","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s43018-022-00411-z","volume":"3","author":"D Lavie","year":"2022","unstructured":"Lavie D, Ben-Shmuel A, Erez N, Scherz-Shouval R. Cancer-associated fibroblasts in the single-cell era. Nat Cancer. 2022;3(7):793\u2013807.","journal-title":"Nat Cancer"},{"issue":"1","key":"7491_CR24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13059-020-02210-0","volume":"21","author":"S He","year":"2020","unstructured":"He S, Wang L-H, Liu Y, Li Y-Q, Chen H-T, Xu J-H, et al. Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs. Genome Biol. 2020;21(1):294.","journal-title":"Genome Biol"},{"issue":"1","key":"7491_CR25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s12967-021-03119-3","volume":"19","author":"M Xu","year":"2021","unstructured":"Xu M, Huang S, Chen J, Xu W, Xiang R, Piao Y, et al. Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR screen could predict prognosis of ovarian cancer patients with distant metastasis. J Transl Med. 2021;19(1):447.","journal-title":"J Transl Med"},{"issue":"11","key":"7491_CR26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.tips.2024.09.005","volume":"45","author":"Z Kaul","year":"2024","unstructured":"Kaul Z, Schwartzberg PL. Balancing immune activation with Itk. Trends Pharmacol Sci. 2024;45(11):958\u201360.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"7491_CR27","doi-asserted-by":"crossref","first-page":"10462","DOI":"10.1038\/s41598-019-45627-9","volume":"9","author":"M Raab","year":"2019","unstructured":"Raab M, Strebhardt K, Rudd CE. Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells. Sci Rep. 2019;9(1):10462.","journal-title":"Sci Rep"},{"key":"7491_CR28","doi-asserted-by":"crossref","first-page":"703534","DOI":"10.3389\/fimmu.2021.703534","volume":"12","author":"N Dadwal","year":"2021","unstructured":"Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, et al. The multiple roles of the cytosolic adapter proteins ADAP, SKAP1 and SKAP2 for TCR\/CD3 -Mediated signaling events. Front Immunol. 2021;12:703534.","journal-title":"Front Immunol"},{"issue":"1","key":"7491_CR29","doi-asserted-by":"crossref","first-page":"20617","DOI":"10.1038\/s41598-023-46794-6","volume":"13","author":"X Li","year":"2023","unstructured":"Li X, Yue Z, Wang D, Zhou L. PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma. Sci Rep. 2023;13(1):20617.","journal-title":"Sci Rep"},{"issue":"1","key":"7491_CR30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40364-024-00570-4","volume":"12","author":"D Hu","year":"2024","unstructured":"Hu D, Zhang Z, Luo X, Li S, Jiang J, Zhang J, et al. Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy. Biomark Res. 2024;12(1):21.","journal-title":"Biomark Res"},{"issue":"8","key":"7491_CR31","doi-asserted-by":"crossref","first-page":"10595","DOI":"10.1007\/s13277-016-4927-z","volume":"37","author":"M Sand","year":"2016","unstructured":"Sand M, Bechara FG, Sand D, Gambichler T, Hahn SA, Bromba M, et al. Long-noncoding RNAs in basal cell carcinoma. Tumour Biol. 2016;37(8):10595\u2013608.","journal-title":"Tumour Biol"},{"key":"7491_CR32","doi-asserted-by":"crossref","unstructured":"Chastney MR, Kaivola J, Lepp\u00e4nen V-M, Ivaska J. The role and regulation of integrins in cell migration and invasion. Nat Rev Mol Cell Biol. 2024.","DOI":"10.1038\/s41580-024-00777-1"},{"issue":"7","key":"7491_CR33","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.7150\/thno.94207","volume":"14","author":"X Jin","year":"2024","unstructured":"Jin X, Deng Q, Ye S, Liu S, Fu Y, Liu Y, et al. Cancer-associated fibroblast-derived Periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling. Theranostics. 2024;14(7):3014\u201328.","journal-title":"Theranostics"},{"issue":"6","key":"7491_CR34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41422-020-0324-7","volume":"30","author":"N Ohkura","year":"2020","unstructured":"Ohkura N, Sakaguchi S. Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases. Cell Res. 2020;30(6):465\u201374.","journal-title":"Cell Res"},{"key":"7491_CR35","doi-asserted-by":"crossref","unstructured":"Wang Z, Ji X, Zhang Y, Yang F, Su H, Zhang H, et al. Interactions between LAMP3\u2009+\u2009dendritic cells and T-cell subpopulations promote immune evasion in papillary thyroid carcinoma. J Immunother Cancer. 2024;12(5).","DOI":"10.1136\/jitc-2024-008983"},{"issue":"2","key":"7491_CR36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.annonc.2023.10.123","volume":"35","author":"KD Lewis","year":"2024","unstructured":"Lewis KD, Peris K, Sekulic A, Stratigos AJ, Dunn L, Eroglu Z, et al. Final analysis of phase II results with Cemiplimab in metastatic basal cell carcinoma after Hedgehog pathway inhibitors. Ann Oncol. 2024;35(2):221\u20138.","journal-title":"Ann Oncol"},{"issue":"6S","key":"7491_CR37","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.jaad.2022.03.022","volume":"86","author":"M Wilson","year":"2022","unstructured":"Wilson M, Johnson RP, Senft SC, Pan EY, Krakowski AC. Advanced basal cell carcinoma: what dermatologists need to know about treatment. J Am Acad Dermatol. 2022;86(6S):S14\u201324.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"7491_CR38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser KE, Joyce JA. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41(3):374\u2013403.","journal-title":"Cancer Cell"},{"issue":"1","key":"7491_CR39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12943-019-0994-2","volume":"18","author":"ME Fiori","year":"2019","unstructured":"Fiori ME, Di Franco S, Villanova L, Bianca P, Stassi G, De Maria R. Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance. Mol Cancer. 2019;18(1):70.","journal-title":"Mol Cancer"},{"key":"7491_CR40","doi-asserted-by":"crossref","unstructured":"Liu Y, Zhang X, Gu W, Su H, Wang X, Wang X, et al. Unlocking the crucial role of cancer-associated fibroblasts in tumor metastasis: mechanisms and therapeutic prospects. J Adv Res. 2024.","DOI":"10.1016\/j.jare.2024.05.031"},{"issue":"12","key":"7491_CR41","doi-asserted-by":"crossref","first-page":"166554","DOI":"10.1016\/j.bbadis.2022.166554","volume":"1868","author":"Z Cong","year":"2022","unstructured":"Cong Z, Yuan F, Wang H, Cai X, Zhu J, Tang T, et al. BTB domain and CNC homolog 1 promotes glioma invasion mainly through regulating extracellular matrix and increases ferroptosis sensitivity. Biochim Biophys Acta Mol Basis Dis. 2022;1868(12):166554.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"11","key":"7491_CR42","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.jid.2018.04.029","volume":"138","author":"F Kuonen","year":"2018","unstructured":"Kuonen F, Surbeck I, Sarin KY, Dontenwill M, R\u00fcegg C, Gilliet M, et al. TGF\u03b2, fibronectin and integrin \u03b15\u03b21 promote invasion in basal cell carcinoma. J Invest Dermatol. 2018;138(11):2432\u201342.","journal-title":"J Invest Dermatol"},{"key":"7491_CR43","doi-asserted-by":"crossref","first-page":"108024","DOI":"10.1016\/j.pharmthera.2021.108024","volume":"233","author":"K Sumaiya","year":"2022","unstructured":"Sumaiya K, Langford D, Natarajaseenivasan K, Shanmughapriya S. Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies. Pharmacol Ther. 2022;233:108024.","journal-title":"Pharmacol Ther"},{"issue":"6","key":"7491_CR44","doi-asserted-by":"crossref","first-page":"189181","DOI":"10.1016\/j.bbcan.2024.189181","volume":"1879","author":"E Nonnast","year":"2024","unstructured":"Nonnast E, Mira E, Ma\u00f1es S. Biomechanical properties of laminins and their impact on cancer progression. Biochim Biophys Acta Rev Cancer. 2024;1879(6):189181.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"5","key":"7491_CR45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10585-015-9705-6","volume":"32","author":"H Sato","year":"2015","unstructured":"Sato H, Higashi S, Miyazaki K. Amino-terminal fragments of laminin \u03b32 chain stimulate migration of metastatic breast cancer cells by interacting with CD44. Clin Exp Metastasis. 2015;32(5):405\u201315.","journal-title":"Clin Exp Metastasis"},{"issue":"1","key":"7491_CR46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13046-016-0475-z","volume":"36","author":"F Bozzi","year":"2017","unstructured":"Bozzi F, Mogavero A, Varinelli L, Belfiore A, Manenti G, Caccia C, et al. MIF\/CD74 axis is a target for novel therapies in colon carcinomatosis. J Exp Clin Cancer Res. 2017;36(1):16.","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07491-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07491-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07491-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T20:03:13Z","timestamp":1767470593000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07491-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7491"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07491-2","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"6 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for the study was obtained from the Ethics Committee and Institutional Review Board of Union Hospital, Fujian Medical University (Fujian, China), and all participants provided written informed consent (approval number: 2025KY002). This study was conducted in accordance with institutional guidelines and the ethical principles of the Declaration of Helsinki (1964) and its subsequent amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}