{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:48:46Z","timestamp":1784684926029,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Chongqing medical scientific research project","award":["2025QNXM048"],"award-info":[{"award-number":["2025QNXM048"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024MD754038"],"award-info":[{"award-number":["2024MD754038"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["82370968"],"award-info":[{"award-number":["82370968"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2022NSCQ-MSX1148"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1148"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07500-4","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:27:42Z","timestamp":1764394062000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multi-omics analysis reveals the association between intratumoral bacteria and somatic mutational signatures in oral squamous cell carcinoma"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-3359","authenticated-orcid":false,"given":"Yunmei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maofeng","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-2761","authenticated-orcid":false,"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"7500_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.oraloncology.2017.05.004","volume":"70","author":"J Ali","year":"2017","unstructured":"Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral Oncol. 2017;70:23\u20138.","journal-title":"Oral Oncol"},{"key":"7500_CR2","doi-asserted-by":"crossref","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2024.","DOI":"10.3322\/caac.21834"},{"issue":"1","key":"7500_CR3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. Cancer J Clin. 2024;74(1):12\u201349.","journal-title":"Cancer J Clin"},{"issue":"1","key":"7500_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41368-023-00265-w","volume":"16","author":"X Zhou","year":"2024","unstructured":"Zhou X, Cai X, Jing F, Li X, Zhang J, Zhang H, Li T. Genomic alterations in oral multiple primary cancers. Int J Oral Sci. 2024;16(1):13.","journal-title":"Int J Oral Sci"},{"key":"7500_CR5","doi-asserted-by":"crossref","unstructured":"Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023;15(1).","DOI":"10.1038\/s41368-023-00249-w"},{"key":"7500_CR6","doi-asserted-by":"publisher","first-page":"106717","DOI":"10.1016\/j.oraloncology.2024.106717","volume":"151","author":"AA Ahmed","year":"2024","unstructured":"Ahmed AA, Sborchia M, Bye H, Roman-Escorza M, Amar A, Henley-Smith R, Odell E, McGurk M, Simpson M, Ng T, et al. Mutation detection in saliva from oral cancer patients. Oral Oncol. 2024;151:106717.","journal-title":"Oral Oncol"},{"key":"7500_CR7","doi-asserted-by":"publisher","first-page":"105547","DOI":"10.1016\/j.oraloncology.2021.105547","volume":"122","author":"CT Liao","year":"2021","unstructured":"Liao CT, Yang LY, Lee LY, Lin CY, Wang HM, Ng SH, Yen TC, Fan WL, Hsieh JC. Whole-exome sequencing identifies biosignatures that predict adverse survival outcomes in surgically treated patients with oral cavity squamous cell carcinoma. Oral Oncol. 2021;122:105547.","journal-title":"Oral Oncol"},{"issue":"7","key":"7500_CR8","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1002\/mco2.636","volume":"5","author":"Y Dong","year":"2024","unstructured":"Dong Y, Zeng K, Ai R, Zhang C, Mao F, Dan H, Zeng X, Ji N, Li J, Jin X, et al. Single-cell transcriptome dissecting the microenvironment remodeled by PD1 Blockade combined with photodynamic therapy in a mouse model of oral carcinogenesis. MedComm (2020). 2024;5(7):e636.","journal-title":"MedComm (2020)"},{"issue":"6","key":"7500_CR9","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s43018-022-00382-1","volume":"3","author":"V Anagnostou","year":"2022","unstructured":"Anagnostou V, Bardelli A, Chan TA, Turajlic S. The status of tumor mutational burden and immunotherapy. Nat Cancer. 2022;3(6):652\u20136.","journal-title":"Nat Cancer"},{"key":"7500_CR10","doi-asserted-by":"crossref","unstructured":"Valero C, Golkaram M, Vos JL, Xu B, Fitzgerald C, Lee M, Kaplan S, Han CY, Pei X, Sarkar R, et al. Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma. J Clin Invest. 2023;133(19).","DOI":"10.1172\/JCI169823"},{"key":"7500_CR11","doi-asserted-by":"crossref","unstructured":"Haddad RI, Seiwert TY, Chow LQM, Gupta S, Weiss J, Gluck I, Eder JP, Burtness B, Tahara M, Keam B, et al. Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma. J Immunother Cancer. 2022;10(2).","DOI":"10.1136\/jitc-2021-003026"},{"issue":"7793","key":"7500_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","volume":"578","author":"LB Alexandrov","year":"2020","unstructured":"Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, et al. The repertoire of mutational signatures in human cancer. Nature. 2020;578(7793):94\u2013101.","journal-title":"Nature"},{"issue":"6494","key":"7500_CR13","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, et al. The human tumor Microbiome is composed of tumor type-specific intracellular bacteria. Science. 2020;368(6494):973\u201380.","journal-title":"Science"},{"key":"7500_CR14","doi-asserted-by":"crossref","unstructured":"Jiang Z, Zhang W, Zhang Z, Sha G, Wang D, Tang D. Intratumoral microbiota: A new force in diagnosing and treating pancreatic cancer. Cancer Lett. 2023;554.","DOI":"10.1016\/j.canlet.2022.216031"},{"key":"7500_CR15","doi-asserted-by":"crossref","unstructured":"Xie Y, Xie F, Zhou X, Zhang L, Yang B, Huang J, Wang F, Yan H, Zeng L, Zhang L, et al. Microbiota in tumors: from Understanding to application. Adv Sci. 2022;9(21).","DOI":"10.1002\/advs.202200470"},{"key":"7500_CR16","doi-asserted-by":"crossref","unstructured":"Yang L, Li A, Wang Y, Zhang Y. Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy. Signal Transduct Target Therapy. 2023;8(1).","DOI":"10.1038\/s41392-022-01304-4"},{"issue":"6","key":"7500_CR17","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","volume":"14","author":"D Lin","year":"2021","unstructured":"Lin D, Yang L, Wen L, Lu H, Chen Q, Wang Z. Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis. Mucosal Immunol. 2021;14(6):1247\u201358.","journal-title":"Mucosal Immunol"},{"issue":"7937","key":"7500_CR18","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s41586-022-05435-0","volume":"611","author":"JL Galeano Ni\u00f1o","year":"2022","unstructured":"Galeano Ni\u00f1o JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E, et al. Effect of the intratumoral microbiota on Spatial and cellular heterogeneity in cancer. Nature. 2022;611(7937):810\u20137.","journal-title":"Nature"},{"key":"7500_CR19","doi-asserted-by":"publisher","first-page":"105657","DOI":"10.1016\/j.oraloncology.2021.105657","volume":"124","author":"Y Dou","year":"2022","unstructured":"Dou Y, Ma C, Wang K, Liu S, Sun J, Tan W, Neckenig M, Wang Q, Dong Z, Gao W, et al. Dysbiotic tumor microbiota associates with head and neck squamous cell carcinoma outcomes. Oral Oncol. 2022;124:105657.","journal-title":"Oral Oncol"},{"key":"7500_CR20","doi-asserted-by":"crossref","unstructured":"Wang H, Funchain P, Bebek G, Altemus J, Zhang H, Niazi F, Peterson C, Lee WT, Burkey BB, Eng C. Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas. Genome Med. 2017;9(1).","DOI":"10.1186\/s13073-017-0405-5"},{"key":"7500_CR21","doi-asserted-by":"crossref","unstructured":"Cai L, Zhu H, Mou Q, Wong PY, Lan L, Ng CWK, Lei P, Cheung MK, Wang D, Wong EWY, et al. Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma. Npj Biofilms Microbiomes. 2024;10(1).","DOI":"10.1038\/s41522-024-00511-x"},{"key":"7500_CR22","doi-asserted-by":"crossref","unstructured":"Sun J, Tang Q, Yu S, Xie M, Zheng W, Chen G, Yin Y, Huang X, Wo K, Lei H, et al. F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. eBioMedicine. 2023;88.","DOI":"10.1016\/j.ebiom.2023.104444"},{"issue":"1","key":"7500_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40164-024-00500-y","volume":"13","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Qin Y, Ma J, Li Z, Heng W, Zhang L, Liu H, Li R, Zhang M, Peng Q, et al. Heat-killed prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment. Exp Hematol Oncol. 2024;13(1):33.","journal-title":"Exp Hematol Oncol"},{"key":"7500_CR24","doi-asserted-by":"crossref","unstructured":"Zhou J, Hu Z, Wang L, Hu Q, Chen Z, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z, et al. Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome. 2024;12(1).","DOI":"10.1186\/s40168-024-01907-9"},{"key":"7500_CR25","doi-asserted-by":"publisher","first-page":"106165","DOI":"10.1016\/j.ijsu.2021.106165","volume":"96","author":"G Mathew","year":"2021","unstructured":"Mathew G, Agha R, Albrecht J, Goel P, Mukherjee I, Pai P, D\u2019Cruz AK, Nixon IJ, Roberto K, Enam SA, et al. STROCSS 2021: strengthening the reporting of cohort, cross-sectional and case-control studies in surgery. Int J Surg (London England). 2021;96:106165.","journal-title":"Int J Surg (London England)"},{"key":"7500_CR26","doi-asserted-by":"crossref","unstructured":"Fuks G, Elgart M, Amir A, Zeisel A, Turnbaugh PJ, Soen Y, Shental N. Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling. Microbiome. 2018;6(1).","DOI":"10.1186\/s40168-017-0396-x"},{"issue":"2","key":"7500_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tim.2018.11.003","volume":"27","author":"R Eisenhofer","year":"2019","unstructured":"Eisenhofer R, Minich JJ, Marotz C, Cooper A, Knight R, Weyrich LS. Contamination in low microbial biomass Microbiome studies: issues and recommendations. Trends Microbiol. 2019;27(2):105\u201317.","journal-title":"Trends Microbiol"},{"key":"7500_CR28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.oraloncology.2019.05.002","volume":"94","author":"A Weckx","year":"2019","unstructured":"Weckx A, Riekert M, Grandoch A, Schick V, Z\u00f6ller JE, Kreppel M. Time to recurrence and patient survival in recurrent oral squamous cell carcinoma. Oral Oncol. 2019;94:8\u201313.","journal-title":"Oral Oncol"},{"issue":"10","key":"7500_CR29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41568-020-0290-x","volume":"20","author":"F Mart\u00ednez-Jim\u00e9nez","year":"2020","unstructured":"Mart\u00ednez-Jim\u00e9nez F, Mui\u00f1os F, Sent\u00eds I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, Mularoni L, Pich O, Bonet J, Kranas H, et al. A compendium of mutational cancer driver genes. Nat Rev Cancer. 2020;20(10):555\u201372.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"7500_CR30","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1038\/s41467-022-30062-8","volume":"13","author":"Q Zhao","year":"2022","unstructured":"Zhao Q, Wang F, Chen YX, Chen S, Yao YC, Zeng ZL, Jiang TJ, Wang YN, Wu CY, Jing Y, et al. Comprehensive profiling of 1015 patients\u2019 exomes reveals genomic-clinical associations in colorectal cancer. Nat Commun. 2022;13(1):2342.","journal-title":"Nat Commun"},{"issue":"5","key":"7500_CR31","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.cell.2017.09.048","volume":"171","author":"BB Campbell","year":"2017","unstructured":"Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin JA, Hodel KP, et al. Comprehensive analysis of hypermutation in human cancer. Cell. 2017;171(5):1042\u2013e10561010.","journal-title":"Cell"},{"issue":"6","key":"7500_CR32","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.trecan.2016.05.006","volume":"2","author":"EB Rankin","year":"2016","unstructured":"Rankin EB, Nam JM, Giaccia AJ. Hypoxia: signaling the metastatic cascade. Trends Cancer. 2016;2(6):295\u2013304.","journal-title":"Trends Cancer"},{"issue":"19","key":"7500_CR33","doi-asserted-by":"publisher","first-page":"4732","DOI":"10.1158\/1078-0432.CCR-10-1408","volume":"16","author":"GQ Zhu","year":"2010","unstructured":"Zhu GQ, Tang YL, Li L, Zheng M, Jiang J, Li XY, Chen SX, Liang XH. Hypoxia inducible factor 1alpha and hypoxia inducible factor 2alpha play distinct and functionally overlapping roles in oral squamous cell carcinoma. Clin Cancer Res. 2010;16(19):4732\u201341.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"7500_CR34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/jre.13173","volume":"58","author":"A Antezack","year":"2023","unstructured":"Antezack A, Etchecopar-Etchart D, La Scola B, Monnet-Corti V. New putative periodontopathogens and periodontal health-associated species: A systematic review and meta-analysis. J Periodontal Res. 2023;58(5):893\u2013906.","journal-title":"J Periodontal Res"},{"issue":"5","key":"7500_CR35","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/0022034519827565","volume":"98","author":"YJ Shin","year":"2019","unstructured":"Shin YJ, Choung HW, Lee JH, Rhyu IC, Kim HD. Association of periodontitis with oral cancer: A Case-Control study. J Dent Res. 2019;98(5):526\u201333.","journal-title":"J Dent Res"},{"issue":"5","key":"7500_CR36","doi-asserted-by":"publisher","first-page":"e0046922","DOI":"10.1128\/msystems.00469-22","volume":"7","author":"W Wei","year":"2022","unstructured":"Wei W, Li J, Shen X, Lyu J, Yan C, Tang B, Ma W, Xie H, Zhao L, Cheng L, et al. Oral microbiota from periodontitis promote oral squamous cell carcinoma development via \u03b3\u03b4 T cell activation. mSystems. 2022;7(5):e0046922.","journal-title":"mSystems"},{"issue":"1","key":"7500_CR37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1034\/j.1600-0765.2002.05019.x","volume":"37","author":"N Ghayoumi","year":"2002","unstructured":"Ghayoumi N, Chen C, Slots J. Dialister pneumosintes, a new putative periodontal pathogen. J Periodontal Res. 2002;37(1):75\u20138.","journal-title":"J Periodontal Res"},{"issue":"6","key":"7500_CR38","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","volume":"67","author":"OO Coker","year":"2018","unstructured":"Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, et al. Mucosal Microbiome dysbiosis in gastric carcinogenesis. Gut. 2018;67(6):1024\u201332.","journal-title":"Gut"},{"issue":"5","key":"7500_CR39","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/s41591-024-02963-2","volume":"30","author":"RY Tito","year":"2024","unstructured":"Tito RY, Verbandt S, Aguirre Vazquez M, Lahti L, Verspecht C, Llor\u00e9ns-Rico V, Vieira-Silva S, Arts J, Falony G, Dekker E, et al. Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development. Nat Med. 2024;30(5):1339\u201348.","journal-title":"Nat Med"},{"issue":"1","key":"7500_CR40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13195-024-01402-1","volume":"16","author":"C Qiu","year":"2024","unstructured":"Qiu C, Zhou W, Shen H, Wang J, Tang R, Wang T, Xie X, Hong B, Ren R, Wang G, et al. Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and alzheimer\u2019s disease. Alzheimers Res Ther. 2024;16(1):41.","journal-title":"Alzheimers Res Ther"},{"key":"7500_CR41","doi-asserted-by":"crossref","unstructured":"Herreros-Pomares A, Herv\u00e1s D, Bagan-Deb\u00f3n L, Jantus-Lewintre E, Gimeno-Cardona C, Bagan J. On the oral Microbiome of oral potentially malignant and malignant disorders: Dysbiosis, loss of diversity, and pathogens enrichment. Int J Mol Sci. 2023;24(4).","DOI":"10.3390\/ijms24043466"},{"issue":"4","key":"7500_CR42","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1002\/imt2.61","volume":"1","author":"D Wu","year":"2022","unstructured":"Wu D, Liu L, Jiao N, Zhang Y, Yang L, Tian C, Lan P, Zhu L, Loomba R, Zhu R. Targeting keystone species helps restore the dysbiosis of butyrate-producing bacteria in nonalcoholic fatty liver disease. iMeta. 2022;1(4):e61.","journal-title":"iMeta"},{"issue":"5788","key":"7500_CR43","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.1127059","volume":"313","author":"JP Nougayr\u00e8de","year":"2006","unstructured":"Nougayr\u00e8de JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 2006;313(5788):848\u201351.","journal-title":"Science"},{"key":"7500_CR44","doi-asserted-by":"crossref","unstructured":"Gao Y, Bi D, Xie R, Li M, Guo J, Liu H, Guo X, Fang J, Ding T, Zhu H, et al. Fusobacterium nucleatum enhances the efficacy of PD-L1 Blockade in colorectal cancer. Signal Transduct Target Therapy. 2021;6(1).","DOI":"10.1038\/s41392-021-00840-9"},{"key":"7500_CR45","doi-asserted-by":"crossref","unstructured":"Wang X, Fang Y, Liang W, Wong CC, Qin H, Gao Y, Liang M, Song L, Zhang Y, Fan M, et al. Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer. Cancer Cell. 2024.","DOI":"10.1016\/S0016-5085(24)00878-3"},{"issue":"18","key":"7500_CR46","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1158\/0008-5472.CAN-22-2593","volume":"83","author":"H Wu","year":"2023","unstructured":"Wu H, Leng XF, Liu QS, Mao TQ, Jiang T, Liu YQ, Li FF, Cao CH, Fan J, Chen L, et al. Intratumoral microbiota composition regulates chemoimmunotherapy response in esophageal squamous cell carcinoma. Cancer Res. 2023;83(18):3131\u201344.","journal-title":"Cancer Res"},{"issue":"9","key":"7500_CR47","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","volume":"186","author":"MJ Bender","year":"2023","unstructured":"Bender MJ, McPherson AC, Phelps CM, Pandey SP, Laughlin CR, Shapira JH, Medina Sanchez L, Rana M, Richie TG, Mims TS, et al. Dietary Tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Cell. 2023;186(9):1846\u2013e18621826.","journal-title":"Cell"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07500-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07500-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07500-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:45:47Z","timestamp":1767627947000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07500-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7500"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07500-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"1 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study conformed to the principles of the Declaration of Helsinki and was approved by the institutional ethical review boards of the Stomatological Hospital of Chongqing Medical University (Ethics No. 2024-087) and the Second Affiliated Hospital of Chongqing Medical University (Ethics No. 2024-064) for anonymous data analysis, and informed consent was waived for this retrospective study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and patient consent statement"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors included in this research declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}