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Ethics approval was granted by the Human Research Ethics Committee of The second Affiliated Hospital of Kunming Medical University (CTR2400084950), ensuring adherence to the ethical standards of the 1964 Declaration of Helsinki and its later amendments. All animal experiment procedures were conducted in accordance with the guidelines of the Animal Ethics, was approved by Institutional Animal Care and Use Commission, Kunming Medical University (approval ID: kmmu20230108) and were compliant with to the \u201cGuide for the Care and Use of Laboratory Animals\u201d (revised 1996).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"271"}}