{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:33:10Z","timestamp":1792683190833,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07534-8","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T04:45:30Z","timestamp":1765773930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Single-cell and spatial atlas unveil tumor-specific microenvironment convergence and a prognosis-associated PLXDC1+ myofibroblast population in metastatic bladder cancer"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-812X","authenticated-orcid":false,"given":"Ziwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidie","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxiong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanliang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"7534_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.5732\/cjc.012.10312","volume":"33","author":"Z-L Zhang","year":"2014","unstructured":"Zhang Z-L, Dong P, Li Y-H, Liu Z-W, Yao K, Han H, et al. Radical cystectomy for bladder cancer: oncologic outcome in 271 Chinese patients. Chin J Cancer. 2014;33:165\u201371. https:\/\/doi.org\/10.5732\/cjc.012.10312.","journal-title":"Chin J Cancer"},{"key":"7534_CR2","doi-asserted-by":"publisher","unstructured":"Li W, Shangguan W, Huang W, Zhao J, Zhu Y, Xie M, et al. Gut parabacteroides distasonis-derived indole-3-acetic acid promotes phospholipid remodeling and enhances ferroptosis sensitivity via the AhR-FASN Axis in bladder cancer. Adv Sci (Weinh). 2025;e04688. https:\/\/doi.org\/10.1002\/advs.202504688.","DOI":"10.1002\/advs.202504688"},{"key":"7534_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ajur.2021.10.002","volume":"10","author":"V Chalfant","year":"2023","unstructured":"Chalfant V, Blute ML, Silberstein P. Treatment trends of muscle invasive bladder cancer: evidence from the surveillance, epidemiology, and end results database, 1988 to 2013. Asian J Urol. 2023;10:9\u201318. https:\/\/doi.org\/10.1016\/j.ajur.2021.10.002.","journal-title":"Asian J Urol"},{"key":"7534_CR4","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1056\/NEJMoa2408154","volume":"391","author":"T Powles","year":"2024","unstructured":"Powles T, Catto JWF, Galsky MD, Al-Ahmadie H, Meeks JJ, Nishiyama H, et al. Perioperative durvalumab with neoadjuvant chemotherapy in operable bladder cancer. N Engl J Med. 2024;391:1773\u201386. https:\/\/doi.org\/10.1056\/NEJMoa2408154.","journal-title":"N Engl J Med"},{"key":"7534_CR5","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1056\/NEJMoa2035807","volume":"384","author":"T Powles","year":"2021","unstructured":"Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Dur\u00e1n I, Lee J-L, et al. Enfortumab Vedotin in Previously treated advanced urothelial carcinoma. N Engl J Med. 2021;384:1125\u201335. https:\/\/doi.org\/10.1056\/NEJMoa2035807.","journal-title":"N Engl J Med"},{"key":"7534_CR6","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1038\/s42003-024-07343-7","volume":"7","author":"S Liu","year":"2024","unstructured":"Liu S, Feng C, Tan L, Zhang D, Li Y-X, Han Y, et al. Single-cell dissection of multifocal bladder cancer reveals malignant and immune cells variation between primary and recurrent tumor lesions. Commun Biol. 2024;7:1659. https:\/\/doi.org\/10.1038\/s42003-024-07343-7.","journal-title":"Commun Biol"},{"key":"7534_CR7","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1186\/s12967-024-05841-0","volume":"22","author":"Y Li","year":"2024","unstructured":"Li Y, Shi P, Ding Y, Yao Z, Liu L, Hu J, et al. Single cell analysis identified a basal cell transition state associated with the development and progression of bladder cancer. J Transl Med. 2024;22:1010. https:\/\/doi.org\/10.1186\/s12967-024-05841-0.","journal-title":"J Transl Med"},{"key":"7534_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41585-024-00951-2","volume":"22","author":"N Kl\u00fcmper","year":"2025","unstructured":"Kl\u00fcmper N, Cox A, Sj\u00f6dahl G, Roghmann F, Bolenz C, Hartmann A, et al. Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer. Nat Rev Urol. 2025;22:256\u201367. https:\/\/doi.org\/10.1038\/s41585-024-00951-2.","journal-title":"Nat Rev Urol"},{"key":"7534_CR9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol. 2024;42:293\u2013304. https:\/\/doi.org\/10.1038\/s41587-023-01767-y.","journal-title":"Nat Biotechnol"},{"key":"7534_CR10","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods. 2019;16:1289\u201396. https:\/\/doi.org\/10.1038\/s41592-019-0619-0.","journal-title":"Nat Methods"},{"key":"7534_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-1-0716-1534-8_10","volume":"2328","author":"N Kumar","year":"2021","unstructured":"Kumar N, Mishra B, Athar M, Mukhtar S. Inference of gene regulatory network from single-cell transcriptomic data using pySCENIC. Methods Mol Biol. 2021;2328:171\u201382. https:\/\/doi.org\/10.1007\/978-1-0716-1534-8_10.","journal-title":"Methods Mol Biol"},{"key":"7534_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s12859-022-04861-1","volume":"23","author":"M Bilous","year":"2022","unstructured":"Bilous M, Tran L, Cianciaruso C, Gabriel A, Michel H, Carmona SJ, et al. Metacells untangle large and complex single-cell transcriptome networks. BMC Bioinf. 2022;23:336. https:\/\/doi.org\/10.1186\/s12859-022-04861-1.","journal-title":"BMC Bioinf"},{"key":"7534_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys R, Saelens W, Saeys Y. NicheNet: modeling intercellular communication by linking ligands to target genes. Nat Methods. 2020;17:159\u201362. https:\/\/doi.org\/10.1038\/s41592-019-0667-5.","journal-title":"Nat Methods"},{"key":"7534_CR14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41587-021-01139-4","volume":"40","author":"V Kleshchevnikov","year":"2022","unstructured":"Kleshchevnikov V, Shmatko A, Dann E, Aivazidis A, King HW, Li T, et al. Cell2location maps fine-grained cell types in spatial transcriptomics. Nat Biotechnol. 2022;40:661\u201371. https:\/\/doi.org\/10.1038\/s41587-021-01139-4.","journal-title":"Nat Biotechnol"},{"key":"7534_CR15","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s43018-022-00356-3","volume":"3","author":"T Chu","year":"2022","unstructured":"Chu T, Wang Z, Pe\u2019er D, Danko CG. Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nat Cancer. 2022;3:505\u201317. https:\/\/doi.org\/10.1038\/s43018-022-00356-3.","journal-title":"Nat Cancer"},{"key":"7534_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13059-022-02663-5","volume":"23","author":"J Tanevski","year":"2022","unstructured":"Tanevski J, Flores ROR, Gabor A, Schapiro D, Saez-Rodriguez J. Explainable multiview framework for dissecting spatial relationships from highly multiplexed data. Genome Biol. 2022;23:97. https:\/\/doi.org\/10.1186\/s13059-022-02663-5.","journal-title":"Genome Biol"},{"key":"7534_CR17","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.1038\/s41467-022-35291-5","volume":"13","author":"L Ma","year":"2022","unstructured":"Ma L, Heinrich S, Wang L, Keggenhoff FL, Khatib S, Forgues M, et al. Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer. Nat Commun. 2022;13:7533. https:\/\/doi.org\/10.1038\/s41467-022-35291-5.","journal-title":"Nat Commun"},{"key":"7534_CR18","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1084\/jem.20121846","volume":"209","author":"Y Yu","year":"2012","unstructured":"Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, et al. Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012;209:2467\u201383. https:\/\/doi.org\/10.1084\/jem.20121846.","journal-title":"J Exp Med"},{"key":"7534_CR19","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1126\/science.ade2292","volume":"381","author":"R Bill","year":"2023","unstructured":"Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, et al. CXCL9: SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science. 2023;381:515\u201324. https:\/\/doi.org\/10.1126\/science.ade2292.","journal-title":"Science"},{"key":"7534_CR20","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/s41556-019-0361-y","volume":"21","author":"X Chen","year":"2019","unstructured":"Chen X, Li A, Sun B-F, Yang Y, Han Y-N, Yuan X, et al. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat Cell Biol. 2019;21:978\u201390. https:\/\/doi.org\/10.1038\/s41556-019-0361-y.","journal-title":"Nat Cell Biol"},{"key":"7534_CR21","doi-asserted-by":"publisher","first-page":"1250719","DOI":"10.3389\/fimmu.2023.1250719","volume":"14","author":"S Horiuchi","year":"2023","unstructured":"Horiuchi S, Koike T, Takebuchi H, Hoshino K, Sasaki I, Fukuda-Ohta Y, et al. SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells. Front Immunol. 2023;14:1250719. https:\/\/doi.org\/10.3389\/fimmu.2023.1250719.","journal-title":"Front Immunol"},{"key":"7534_CR22","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1038\/s41375-021-01198-1","volume":"35","author":"L Lla\u00f3-Cid","year":"2021","unstructured":"Lla\u00f3-Cid L, Roessner PM, Chapaprieta V, \u00d6zt\u00fcrk S, Roider T, Bordas M, et al. EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia. Leukemia. 2021;35:3152\u201362. https:\/\/doi.org\/10.1038\/s41375-021-01198-1.","journal-title":"Leukemia"},{"key":"7534_CR23","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1038\/s41467-021-25758-2","volume":"12","author":"J Zhang","year":"2021","unstructured":"Zhang J, Le Gras S, Pouxvielh K, Faure F, Fallone L, Kern N, et al. Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells. Nat Commun. 2021;12:5446. https:\/\/doi.org\/10.1038\/s41467-021-25758-2.","journal-title":"Nat Commun"},{"key":"7534_CR24","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/s41590-018-0238-4","volume":"19","author":"H Hosokawa","year":"2018","unstructured":"Hosokawa H, Romero-Wolf M, Yui MA, Ungerb\u00e4ck J, Quiloan MLG, Matsumoto M, et al. Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nat Immunol. 2018;19:1427\u201340. https:\/\/doi.org\/10.1038\/s41590-018-0238-4.","journal-title":"Nat Immunol"},{"key":"7534_CR25","doi-asserted-by":"publisher","first-page":"783780","DOI":"10.3389\/fimmu.2021.783780","volume":"12","author":"D Toobian","year":"2021","unstructured":"Toobian D, Ghosh P, Katkar GD. Parsing the role of PPARs in macrophage processes. Front Immunol. 2021;12:783780. https:\/\/doi.org\/10.3389\/fimmu.2021.783780.","journal-title":"Front Immunol"},{"key":"7534_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1538\/expanim.19-0076","volume":"69","author":"M Hamada","year":"2020","unstructured":"Hamada M, Tsunakawa Y, Jeon H, Yadav MK, Takahashi S. Role of MafB in macrophages. Exp Anim. 2020;69:1\u201310. https:\/\/doi.org\/10.1538\/expanim.19-0076.","journal-title":"Exp Anim"},{"key":"7534_CR27","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1074\/jbc.RA119.011822","volume":"295","author":"J Klomp","year":"2020","unstructured":"Klomp J, Hyun J, Klomp JE, Pajcini K, Rehman J, Malik AB. Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells. J Biol Chem. 2020;295:4796\u2013808. https:\/\/doi.org\/10.1074\/jbc.RA119.011822.","journal-title":"J Biol Chem"},{"key":"7534_CR28","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.immuni.2017.11.021","volume":"47","author":"K Man","year":"2017","unstructured":"Man K, Gabriel SS, Liao Y, Gloury R, Preston S, Henstridge DC, et al. Transcription factor IRF4 promotes CD8+ T cell exhaustion and limits the development of memory-like T cells during chronic infection. Immunity. 2017;47:1129\u201341.e5. https:\/\/doi.org\/10.1016\/j.immuni.2017.11.021.","journal-title":"Immunity"},{"key":"7534_CR29","doi-asserted-by":"publisher","first-page":"eadf6717","DOI":"10.1126\/sciimmunol.adf6717","volume":"8","author":"F Shan","year":"2023","unstructured":"Shan F, Cillo AR, Cardello C, Yuan DY, Kunning SR, Cui J, et al. Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells. Sci Immunol. 2023;8:eadf6717. https:\/\/doi.org\/10.1126\/sciimmunol.adf6717.","journal-title":"Sci Immunol"},{"key":"7534_CR30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s12931-019-1264-y","volume":"20","author":"I Wojahn","year":"2019","unstructured":"Wojahn I, L\u00fcdtke TH, Christoffels VM, Trowe M-O, Kispert A. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung. Respir Res. 2019;20:292. https:\/\/doi.org\/10.1186\/s12931-019-1264-y.","journal-title":"Respir Res"},{"key":"7534_CR31","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.ccell.2021.09.003","volume":"39","author":"H Hu","year":"2021","unstructured":"Hu H, Piotrowska Z, Hare PJ, Chen H, Mulvey HE, Mayfield A, et al. Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. Cancer Cell. 2021;39:1531\u201347.e10. https:\/\/doi.org\/10.1016\/j.ccell.2021.09.003.","journal-title":"Cancer Cell"},{"key":"7534_CR32","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1111\/jcmm.14914","volume":"24","author":"W-W Bai","year":"2020","unstructured":"Bai W-W, Tang Z-Y, Shan T-C, Jing X-J, Li P, Qin W-D, et al. Up-regulation of paired-related homeobox 2 promotes cardiac fibrosis in mice following myocardial infarction by targeting of Wnt5a. J Cell Mol Med. 2020;24:2319\u201329. https:\/\/doi.org\/10.1111\/jcmm.14914.","journal-title":"J Cell Mol Med"},{"key":"7534_CR33","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1038\/s41467-022-30484-4","volume":"13","author":"K-W Lee","year":"2022","unstructured":"Lee K-W, Yeo S-Y, Gong J-R, Koo O-J, Sohn I, Lee WY, et al. PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Nat Commun. 2022;13:2793. https:\/\/doi.org\/10.1038\/s41467-022-30484-4.","journal-title":"Nat Commun"},{"key":"7534_CR34","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1038\/s44319-024-00186-7","volume":"25","author":"C Menche","year":"2024","unstructured":"Menche C, Schuhwerk H, Armstark I, Gupta P, Fuchs K, van Roey R, et al. ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer. EMBO Rep. 2024;25:3406\u201331. https:\/\/doi.org\/10.1038\/s44319-024-00186-7.","journal-title":"EMBO Rep"},{"key":"7534_CR35","doi-asserted-by":"publisher","first-page":"14824","DOI":"10.1074\/jbc.M113.451336","volume":"288","author":"AC Midgley","year":"2013","unstructured":"Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, et al. Transforming growth factor-\u03b21 (TGF-\u03b21)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. J Biol Chem. 2013;288:14824\u201338. https:\/\/doi.org\/10.1074\/jbc.M113.451336.","journal-title":"J Biol Chem"},{"key":"7534_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu X, Li J, Fu M, Zhao X, Wang W. The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6:402. https:\/\/doi.org\/10.1038\/s41392-021-00791-1.","journal-title":"Signal Transduct Target Ther"},{"key":"7534_CR37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jconrel.2024.12.073","volume":"379","author":"S Chen","year":"2025","unstructured":"Chen S, Jiang Y, Zheng J, Li P, Liu M, Zhu Y, et al. Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer. J Control Release. 2025;379:89\u2013104. https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.073.","journal-title":"J Control Release"},{"key":"7534_CR38","doi-asserted-by":"publisher","first-page":"e009368","DOI":"10.1136\/jitc-2024-009368","volume":"12","author":"H Al-Janabi","year":"2024","unstructured":"Al-Janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, et al. Targeting a sting agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy. J Immunother Cancer. 2024;12:e009368. https:\/\/doi.org\/10.1136\/jitc-2024-009368.","journal-title":"J Immunother Cancer"},{"key":"7534_CR39","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/s1534-5807(02)00217-4","volume":"3","author":"NW Gale","year":"2002","unstructured":"Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002;3:411\u201323. https:\/\/doi.org\/10.1016\/s1534-5807(02)00217-4.","journal-title":"Dev Cell"},{"key":"7534_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3858\/emm.2012.44.1.025","volume":"44","author":"S De Falco","year":"2012","unstructured":"De Falco S. The discovery of placenta growth factor and its biological activity. Exp Mol Med. 2012;44:1\u20139. https:\/\/doi.org\/10.3858\/emm.2012.44.1.025.","journal-title":"Exp Mol Med"},{"key":"7534_CR41","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1007\/s00018-011-0781-8","volume":"68","author":"LB Rivera","year":"2011","unstructured":"Rivera LB, Bradshaw AD, Brekken RA. The regulatory function of SPARC in vascular biology. Cell Mol Life Sci. 2011;68:3165\u201373. https:\/\/doi.org\/10.1007\/s00018-011-0781-8.","journal-title":"Cell Mol Life Sci"},{"key":"7534_CR42","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ccell.2024.02.002","volume":"42","author":"H Zheng","year":"2024","unstructured":"Zheng H, An M, Luo Y, Diao X, Zhong W, Pang M, et al. PDGFR\u03b1+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. Cancer Cell. 2024;42:682\u2013700.e12. https:\/\/doi.org\/10.1016\/j.ccell.2024.02.002.","journal-title":"Cancer Cell"},{"key":"7534_CR43","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.ccell.2022.11.005","volume":"40","author":"Z Ma","year":"2022","unstructured":"Ma Z, Li X, Mao Y, Wei C, Huang Z, Li G, et al. Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer. Cancer Cell. 2022;40:1550\u201365.e7. https:\/\/doi.org\/10.1016\/j.ccell.2022.11.005.","journal-title":"Cancer Cell"},{"key":"7534_CR44","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1084\/jem.20122344","volume":"210","author":"EW Roberts","year":"2013","unstructured":"Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, et al. Depletion of stromal cells expressing fibroblast activation protein-\u03b1 from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med. 2013;210:1137\u201351. https:\/\/doi.org\/10.1084\/jem.20122344.","journal-title":"J Exp Med"},{"key":"7534_CR45","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1158\/0008-5472.CAN-21-3734","volume":"82","author":"U Ray","year":"2022","unstructured":"Ray U, Pathoulas CL, Thirusangu P, Purcell JW, Kannan N, Shridhar V. Exploiting LRRC15 as a novel therapeutic target in cancer. Cancer Res. 2022;82:1675\u201381. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-3734.","journal-title":"Cancer Res"},{"key":"7534_CR46","doi-asserted-by":"publisher","first-page":"216074","DOI":"10.1016\/j.canlet.2023.216074","volume":"556","author":"Z Jiang","year":"2023","unstructured":"Jiang Z, Zhou J, Li L, Liao S, He J, Zhou S, et al. Pericytes in the tumor microenvironment. Cancer Lett. 2023;556:216074. https:\/\/doi.org\/10.1016\/j.canlet.2023.216074.","journal-title":"Cancer Lett"},{"key":"7534_CR47","doi-asserted-by":"publisher","first-page":"L848","DOI":"10.1152\/ajplung.00296.2020","volume":"319","author":"SE Stephenson","year":"2020","unstructured":"Stephenson SE, Wilson CL, Bond NG, Kaur A, Alvarez X, Midkiff CC, et al. Pericytes as novel targets for HIV\/SIV infection in the lung. Am J Physiol Lung Cell Mol Physiol. 2020;319:L848\u201353. https:\/\/doi.org\/10.1152\/ajplung.00296.2020.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"7534_CR48","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.1038\/s41467-021-26259-y","volume":"12","author":"Y-M Meng","year":"2021","unstructured":"Meng Y-M, Jiang X, Zhao X, Meng Q, Wu S, Chen Y, et al. Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities. Nat Commun. 2021;12:6011. https:\/\/doi.org\/10.1038\/s41467-021-26259-y.","journal-title":"Nat Commun"},{"key":"7534_CR49","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1007\/s10565-023-09814-9","volume":"39","author":"LS Brown","year":"2023","unstructured":"Brown LS, King NE, Courtney J-M, Gasperini RJ, Foa L, Howells DW, et al. Brain pericytes in culture display diverse morphological and functional phenotypes. Cell Biol Toxicol. 2023;39:2999\u20133014. https:\/\/doi.org\/10.1007\/s10565-023-09814-9.","journal-title":"Cell Biol Toxicol"},{"key":"7534_CR50","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nprot.2017.158","volume":"13","author":"EE Crouch","year":"2018","unstructured":"Crouch EE, Doetsch F. FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc. 2018;13:738\u201351. https:\/\/doi.org\/10.1038\/nprot.2017.158.","journal-title":"Nat Protoc"},{"key":"7534_CR51","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-1-0716-1056-5_12","volume":"2235","author":"A Stefanska","year":"2021","unstructured":"Stefanska A, Briski A, Khan NS, Kenyon C, P\u00e9ault BM, Mullins JJ. Role of pericytes in the development of the Renin\/Angiotensin system: induction of functional Renin in cultures of pericytes. Methods Mol Biol. 2021;2235:169\u201380. https:\/\/doi.org\/10.1007\/978-1-0716-1056-5_12.","journal-title":"Methods Mol Biol"},{"key":"7534_CR52","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s00125-019-4865-6","volume":"62","author":"G Mangialardi","year":"2019","unstructured":"Mangialardi G, Ferland-McCollough D, Maselli D, Santopaolo M, Cordaro A, Spinetti G, et al. Bone marrow pericyte dysfunction in individuals with type 2 diabetes. Diabetologia. 2019;62:1275\u201390. https:\/\/doi.org\/10.1007\/s00125-019-4865-6.","journal-title":"Diabetologia"},{"key":"7534_CR53","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.omtm.2019.09.002","volume":"15","author":"CRM Ausems","year":"2019","unstructured":"Ausems CRM, Raaijmakers RHL, van den Broek WJAA, Willemse M, van Engelen BGM, Wansink DG, et al. Intrinsic myogenic potential of skeletal muscle-derived pericytes from patients with myotonic dystrophy type 1. Mol Ther Methods Clin Dev. 2019;15:120\u201332. https:\/\/doi.org\/10.1016\/j.omtm.2019.09.002.","journal-title":"Mol Ther Methods Clin Dev"},{"key":"7534_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.csbj.2018.11.004","volume":"17","author":"NR Maimela","year":"2019","unstructured":"Maimela NR, Liu S, Zhang Y. Fates of CD8+ T cells in tumor microenvironment. Comput Struct Biotechnol J. 2019;17:1\u201313. https:\/\/doi.org\/10.1016\/j.csbj.2018.11.004.","journal-title":"Comput Struct Biotechnol J"},{"key":"7534_CR55","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s42003-025-08094-9","volume":"8","author":"Z Liu","year":"2025","unstructured":"Liu Z, Mao X, Xie Y, Yan Y, Wang X, Mi J, et al. Single-cell rna sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer. Commun Biol. 2025;8:696. https:\/\/doi.org\/10.1038\/s42003-025-08094-9.","journal-title":"Commun Biol"},{"key":"7534_CR56","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","volume":"8","author":"D Jorgovanovic","year":"2020","unstructured":"Jorgovanovic D, Song M, Wang L, Zhang Y. Roles of IFN-\u03b3 in tumor progression and regression: a review. Biomark Res. 2020;8:49. https:\/\/doi.org\/10.1186\/s40364-020-00228-x.","journal-title":"Biomark Res"},{"key":"7534_CR57","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/s41598-021-04678-7","volume":"12","author":"E Olkhov-Mitsel","year":"2022","unstructured":"Olkhov-Mitsel E, Hodgson A, Liu SK, Vesprini D, Bayani J, Bartlett JMS, et al. Upregulation of IFN\u0263-mediated chemokines dominate the immune transcriptome of muscle-invasive urothelial carcinoma. Sci Rep. 2022;12:716. https:\/\/doi.org\/10.1038\/s41598-021-04678-7.","journal-title":"Sci Rep"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07534-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07534-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07534-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:39:40Z","timestamp":1768916380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07534-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7534"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07534-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"16 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients provided written informed consent prior to specimen collection. Sample collection followed a standardized protocol approved by the Ethics Committee of Changhai Hospital, Shanghai, China (Approval No. CHEC2023-306). All experiments were conducted in accordance with the International Ethical Guidelines for Biomedical Research Involving Human Subjects (CIOMS).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"88"}}