{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:28:49Z","timestamp":1776454129018,"version":"3.51.2"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72374227"],"award-info":[{"award-number":["72374227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220818103608017"],"award-info":[{"award-number":["JCYJ20220818103608017"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"name":"President Foundation of The Third Affiliated Hospital of Southern Medical University","award":["YQ202410"],"award-info":[{"award-number":["YQ202410"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07565-1","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T03:17:05Z","timestamp":1765941425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased first-trimester CA125 levels associated with the development of preeclampsia"],"prefix":"10.1186","volume":"24","author":[{"given":"Aiqi","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonian","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-5994","authenticated-orcid":false,"given":"Jianmin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"7565_CR1","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1056\/NEJMra2109523","volume":"386","author":"LA Magee","year":"2022","unstructured":"Magee LA, Nicolaides KH. Von Dadelszen P: preeclampsia. N Engl J Med. 2022;386:1817\u201332.","journal-title":"N Engl J Med"},{"key":"7565_CR2","doi-asserted-by":"publisher","first-page":"103780","DOI":"10.1016\/j.ebiom.2021.103780","volume":"75","author":"TM MacDonald","year":"2021","unstructured":"MacDonald TM, Walker SP, Hannan NJ, Tong S. Kaitu\u2019U-Lino TJ: clinical tools and biomarkers to predict preeclampsia. EBioMedicine. 2021;75:103780.","journal-title":"EBioMedicine"},{"key":"7565_CR3","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","volume":"398","author":"LC Chappell","year":"2021","unstructured":"Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia. Lancet. 2021;398:341\u201354.","journal-title":"Lancet"},{"key":"7565_CR4","unstructured":"Myatt L. The prediction of preeclampsia: the way forward. Am J Obstet Gynecol 2020."},{"key":"7565_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","volume":"9","author":"E Dimitriadis","year":"2023","unstructured":"Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco R, Whitehead C, Hyett J, Da SCF, Nicolaides K, Menkhorst E. Pre-eclampsia. Nat Rev Dis Primers. 2023;9:8.","journal-title":"Nat Rev Dis Primers"},{"key":"7565_CR6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s10020-024-01050-z","volume":"30","author":"C Li","year":"2024","unstructured":"Li C, Meng Y, Zhou B, Zhang Y, Xia Q, Huang Y, Meng L, Shan C, Xia J, Zhang X, et al. ITGB3 is reduced in pregnancies with preeclampsia and its influence on biological behavior of trophoblast cells. Mol Med. 2024;30:275.","journal-title":"Mol Med"},{"key":"7565_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.preghy.2020.03.011","volume":"20","author":"S Suvakov","year":"2020","unstructured":"Suvakov S, Bonner E, Nikolic V, Jerotic D, Simic TP, Garovic VD, Lopez-Campos G, McClements L. Overlapping pathogenic signalling pathways and biomarkers in preeclampsia and cardiovascular disease. Pregnancy Hypertens. 2020;20:131\u20136.","journal-title":"Pregnancy Hypertens"},{"key":"7565_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1159\/000064032","volume":"23","author":"TJ O\u2019Brien","year":"2002","unstructured":"O\u2019Brien TJ, Beard JB, Underwood LJ, Shigemasa K. The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumour Biol. 2002;23:154\u201369.","journal-title":"Tumour Biol"},{"key":"7565_CR9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/ijc.10250","volume":"98","author":"BW Yin","year":"2002","unstructured":"Yin BW, Dnistrian A, Lloyd KO. Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. Int J Cancer. 2002;98:737\u201340.","journal-title":"Int J Cancer"},{"key":"7565_CR10","doi-asserted-by":"publisher","first-page":"188503","DOI":"10.1016\/j.bbcan.2021.188503","volume":"1875","author":"M Zhang","year":"2021","unstructured":"Zhang M, Cheng S, Jin Y, Zhao Y, Wang Y. Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer. Biochim Biophys Acta Rev Cancer. 2021;1875:188503.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"7565_CR11","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/j.1432-0436.2008.00295.x","volume":"76","author":"Y Wang","year":"2008","unstructured":"Wang Y, Cheon DJ, Lu Z, Cunningham SL, Chen CM, Luo RZ, Xing D, Orsulic S, Bast RJ, Behringer RR. MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse. Differentiation. 2008;76:1081\u201392.","journal-title":"Differentiation"},{"key":"7565_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/00004347-198303000-00005","volume":"2","author":"SE Kabawat","year":"1983","unstructured":"Kabawat SE, Bast RJ, Bhan AK, Welch WR, Knapp RC, Colvin RB. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol. 1983;2:275\u201385.","journal-title":"Int J Gynecol Pathol"},{"key":"7565_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.abb.2018.06.017","volume":"653","author":"N Mitic","year":"2018","unstructured":"Mitic N, Kosanovic M, Milutinovic B, Goc S, Mladenovic D, Grubisa I, Jankovic M. Nano-sized CA125 antigen glycocamouflage: Mucin - Extracellular vesicles alliance to watch? Arch Biochem Biophys. 2018;653:113\u201320.","journal-title":"Arch Biochem Biophys"},{"key":"7565_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0028-2243(93)90131-U","volume":"49","author":"P Bischof","year":"1993","unstructured":"Bischof P. What do we know about the origin of CA 125? Eur J Obstet Gynecol Reprod Biol. 1993;49:93\u20138.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"7565_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2217\/bmm-2017-0452","volume":"12","author":"F Falcao","year":"2018","unstructured":"Falcao F, de Oliveira F, Da SM, Sobral FD. Carbohydrate antigen 125: a promising tool for risk stratification in heart diseases. Biomark Med. 2018;12:367\u201381.","journal-title":"Biomark Med"},{"key":"7565_CR16","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/ejhf.2295","volume":"23","author":"J Nunez","year":"2021","unstructured":"Nunez J, de la Espriella R, Minana G, Santas E, Llacer P, Nunez E, Palau P, Bodi V, Chorro FJ, Sanchis J, et al. Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review. Eur J Heart Fail. 2021;23:1445\u201357.","journal-title":"Eur J Heart Fail"},{"key":"7565_CR17","doi-asserted-by":"crossref","unstructured":"de la Espriella R, Bayes-Genis A, Llacer P, Palau P, Minana G, Santas E, Pellicer M, Gonzalez M, Gorriz JL, Bodi V et al. Prognostic value of NT-proBNP and CA125 across glomerular filtration rate categories in acute heart failure. Eur J Intern Med 2021.","DOI":"10.1016\/j.ejim.2021.08.024"},{"key":"7565_CR18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clinbiochem.2020.12.010","volume":"89","author":"A Sahin","year":"2021","unstructured":"Sahin A, Kaya H, Avci O. Cancer antigen-125 is a predictor of mortality in patients with pulmonary arterial hypertension. Clin Biochem. 2021;89:58\u201362.","journal-title":"Clin Biochem"},{"key":"7565_CR19","doi-asserted-by":"publisher","first-page":"11016","DOI":"10.1038\/s41598-020-67548-8","volume":"10","author":"F Falcao","year":"2020","unstructured":"Falcao F, Oliveira F, Cantarelli F, Cantarelli R, Brito JP, Lemos H, Silva P, Camboim I, Freire MC, Carvalho O, Sobral FD. Carbohydrate antigen 125 for mortality risk prediction following acute myocardial infarction. Sci Rep. 2020;10:11016.","journal-title":"Sci Rep"},{"key":"7565_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.4103\/npmj.npmj_241_20","volume":"27","author":"BM Sayyadi","year":"2020","unstructured":"Sayyadi BM, Takai IU, Ibrahim SA, Abdulsalam K, Ibrahim UM. CA125 levels in pregnancy: A case-control study amongst pregnant women in Aminu Kano teaching hospital, North-West Nigeria. Niger Postgrad Med J. 2020;27:325\u201330.","journal-title":"Niger Postgrad Med J"},{"key":"7565_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/10641955.2018.1460667","volume":"37","author":"GE Osanyin","year":"2018","unstructured":"Osanyin GE, Okunade KS, Ayotunde OA. Association between serum CA125 levels in preeclampsia and its severity among women in Lagos, South-West Nigeria. Hypertens Pregnancy. 2018;37:93\u20137.","journal-title":"Hypertens Pregnancy"},{"key":"7565_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.preghy.2013.08.003","volume":"4","author":"E Karaman","year":"2014","unstructured":"Karaman E, Karaman Y, Alkis I, Han A, Yildirim G, Ark HC. Maternal serum CA-125 level is elevated in severe preeclampsia. Pregnancy Hypertens. 2014;4:29\u201333.","journal-title":"Pregnancy Hypertens"},{"key":"7565_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00404-010-1736-2","volume":"284","author":"M Ozat","year":"2011","unstructured":"Ozat M, Kanat-Pektas M, Yenicesu O, Gungor T, Danisman N, Mollamahmutoglu L. Serum concentrations of CA-125 in normal and preeclamptic pregnancies. Arch Gynecol Obstet. 2011;284:607\u201312.","journal-title":"Arch Gynecol Obstet"},{"key":"7565_CR24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/10641950802601187","volume":"28","author":"FB Cebesoy","year":"2009","unstructured":"Cebesoy FB, Balat O, Dikensoy E, Kalayci H, Ibar Y. CA-125 and CRP are elevated in preeclampsia. Hypertens Pregnancy. 2009;28:201\u201311.","journal-title":"Hypertens Pregnancy"},{"key":"7565_CR25","doi-asserted-by":"publisher","first-page":"e13380","DOI":"10.1111\/ijcp.13380","volume":"73","author":"I Bellos","year":"2019","unstructured":"Bellos I, Pergialiotis V, Loutradis D, Papapanagiotou A, Daskalakis G. Serum CA-125 levels in preeclampsia: A systematic review and meta-analysis. Int J Clin Pract. 2019;73:e13380.","journal-title":"Int J Clin Pract"},{"key":"7565_CR26","doi-asserted-by":"crossref","unstructured":"ACOG Practice Bulletin No. 203: Chronic Hypertension in Pregnancy. Obstet Gynecol. 2019, 133:e26-e50.","DOI":"10.1097\/AOG.0000000000003020"},{"key":"7565_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/uog.22134","volume":"56","author":"CC Lees","year":"2020","unstructured":"Lees CC, Stampalija T, Baschat A, Da SCF, Ferrazzi E, Figueras F, Hecher K, Kingdom J, Poon LC, Salomon LJ, Unterscheider J. ISUOG practice guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction. Ultrasound Obstet Gynecol. 2020;56:298\u2013312.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"Suppl 1","key":"7565_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ijgo.13522","volume":"152","author":"N Melamed","year":"2021","unstructured":"Melamed N, Baschat A, Yinon Y, Athanasiadis A, Mecacci F, Figueras F, Berghella V, Nazareth A, Tahlak M, McIntyre HD, et al. FIGO (international federation of gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction. Int J Gynaecol Obstet. 2021;152(Suppl 1):3\u201357.","journal-title":"Int J Gynaecol Obstet"},{"key":"7565_CR29","doi-asserted-by":"publisher","first-page":"959239","DOI":"10.3389\/fcell.2022.959239","volume":"10","author":"A Yin","year":"2022","unstructured":"Yin A, Guan X, Zhang JV, Niu J. Focusing on the role of secretin\/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia. Front Cell Dev Biol. 2022;10:959239.","journal-title":"Front Cell Dev Biol"},{"key":"7565_CR30","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1161\/HYPERTENSIONAHA.124.24117","volume":"82","author":"G Santulli","year":"2025","unstructured":"Santulli G, Kansakar U, Varzideh F. Epidemiology and pathophysiology of preeclampsia: new mechanistic insights. Hypertension. 2025;82:800\u20133.","journal-title":"Hypertension"},{"key":"7565_CR31","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1186\/s12916-024-03797-y","volume":"22","author":"D Westergaard","year":"2024","unstructured":"Westergaard D, Lundgaard AT, Vomstein K, Fich L, Hviid K, Egerup P, Christiansen AH, Nielsen JR, Lindman J, Holm PC, et al. Immune changes in pregnancy: associations with pre-existing conditions and obstetrical complications at the 20th gestational week-a prospective cohort study. BMC Med. 2024;22:583.","journal-title":"BMC Med"},{"key":"7565_CR32","doi-asserted-by":"crossref","unstructured":"Illarionov RA, Maltseva AR, Pachuliia OV, Postnikova TB, Vashukova ES, Popova AK, Nasykhova YA, Bespalova ON, Glotov AS. Urinary MiRNA expression in pre-eclampsia during early and mid-pregnancy. Noncoding RNA 2024, 10.","DOI":"10.3390\/ncrna10060061"},{"issue":"Suppl 1","key":"7565_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijgo.12802","volume":"145","author":"LC Poon","year":"2019","unstructured":"Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, Da SCF, von Dadelszen P, McIntyre HD, et al. The international federation of gynecology and obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 2019;145(Suppl 1):1\u201333.","journal-title":"Int J Gynaecol Obstet"},{"key":"7565_CR34","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.119.13763","volume":"75","author":"H Stepan","year":"2020","unstructured":"Stepan H, Hund M, Andraczek T. Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the Angiogenic-Placental syndrome. Hypertension. 2020;75:918\u201326.","journal-title":"Hypertension"},{"key":"7565_CR35","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/HYPERTENSIONAHA.119.13360","volume":"74","author":"S Agrawal","year":"2019","unstructured":"Agrawal S, Shinar S, Cerdeira AS, Redman C, Vatish M. Predictive performance of PlGF (Placental growth Factor) for screening preeclampsia in asymptomatic women: A systematic review and Meta-Analysis. Hypertension. 2019;74:1124\u201335.","journal-title":"Hypertension"},{"key":"7565_CR36","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1056\/NEJMoa031884","volume":"350","author":"RJ Levine","year":"2004","unstructured":"Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672\u201383.","journal-title":"N Engl J Med"},{"key":"7565_CR37","doi-asserted-by":"crossref","unstructured":"Vornic I, Caprariu R, Novacescu D, Barb AC, Buciu V, Baloi A, Szekely D, Suciu CS, Dumitru C, Patrascu R et al. Molecular insights into human placentation: from villous morphogenesis to pathological pathways and translational biomarkers. Int J Mol Sci. 2025;26.","DOI":"10.3390\/ijms26199483"},{"key":"7565_CR38","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/uog.15807","volume":"47","author":"D Wright","year":"2016","unstructured":"Wright D, Gallo DM, Gil PS, Casanova C, Nicolaides KH. Contingent screening for preterm pre-eclampsia. Ultrasound Obstet Gynecol. 2016;47:554\u20139.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7565_CR39","first-page":"651","volume":"22","author":"H Gholami","year":"2024","unstructured":"Gholami H, Garrosi L, Tofighi S, Ghadimi Z. The association among cancer-antigen-125 and pre-eclampsia and estimated fetal weight: A case-control study. Int J Reprod Biomed. 2024;22:651\u201360.","journal-title":"Int J Reprod Biomed"},{"key":"7565_CR40","doi-asserted-by":"crossref","unstructured":"Balint O, Secosan C, Pirtea L. Role of CA-125 level as a marker in the management of severe pre-eclampsia. Healthc (Basel). 2022;10.","DOI":"10.3390\/healthcare10122474"},{"key":"7565_CR41","doi-asserted-by":"crossref","unstructured":"Santas E, Marti-Martinez A, Villar S, de la Espriella R, Rodriguez-Borja E, Revuelta-Lopez E, Gonzalez-Miqueo A, Bayes-Genis A, Sanchis J, Nunez J. Cytokine networks and heart failure outcomes: CA125 as a Bridge between congestion and inflammation. Int J Mol Sci. 2025;26.","DOI":"10.3390\/ijms26199527"},{"key":"7565_CR42","doi-asserted-by":"crossref","unstructured":"Santas E, Marti-Martinez A, Revuelta-Lopez E, Villar S, de la Espriella R, Palau P, Llacer P, Minana G, Rodriguez-Borja E, Carratala A, et al. Modulating effect of carbohydrate antigen 125 on the prognostic value of high-sensitivity C-reactive protein in heart failure. Biomolecules. 2025;15.","DOI":"10.3390\/biom15091260"},{"key":"7565_CR43","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1186\/s12967-024-05351-z","volume":"22","author":"S Eiras","year":"2024","unstructured":"Eiras S, de la Espriella R, Fu X, Iglesias-Alvarez D, Basdas R, Nunez-Caamano JR, Martinez-Cereijo JM, Reija L, Fernandez AL, Sanchez-Lopez D, et al. Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers. J Transl Med. 2024;22:619.","journal-title":"J Transl Med"},{"key":"7565_CR44","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1242\/jcs.00312","volume":"116","author":"C Seelenmeyer","year":"2003","unstructured":"Seelenmeyer C, Wegehingel S, Lechner J, Nickel W. The cancer antigen CA125 represents a novel counter receptor for galectin-1. J Cell Sci. 2003;116:1305\u201318.","journal-title":"J Cell Sci"},{"key":"7565_CR45","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s40842-024-00212-6","volume":"10","author":"R Vamja","year":"2024","unstructured":"Vamja R, M Y, Patel M, Vala V, Ramachandran A, Surati B, Nagda J. Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study. Clin Diabetes Endocrinol. 2024;10:50.","journal-title":"Clin Diabetes Endocrinol"},{"key":"7565_CR46","doi-asserted-by":"publisher","first-page":"1489097","DOI":"10.3389\/fendo.2024.1489097","volume":"15","author":"Z Wang","year":"2024","unstructured":"Wang Z, Guo S, Xie Y, Tong Y, Qi W, Wang Z. Endometrial expression of ERRbeta and errgamma: prognostic significance and clinical correlations in severe endometriosis. Front Endocrinol (Lausanne). 2024;15:1489097.","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07565-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07565-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07565-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:28:49Z","timestamp":1768994929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07565-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7565"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07565-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"23 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study utilized data from the Birth Cohort in Shenzhen (BiCoS), a prospective birth cohort study conducted by Shenzhen Maternity & Child Healthcare Hospital. The study protocol was approved by the Institutional Review Board of Shenzhen Maternity & Child Healthcare Hospital (Approval No. 23) and strictly adhered to the ethical principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"97"}}