{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:23:54Z","timestamp":1780475034343,"version":"3.54.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Heilongjiang Charity Federation","award":["2022HX012"],"award-info":[{"award-number":["2022HX012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07590-0","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:05:35Z","timestamp":1765987535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baicalin affects the progression of diabetic retinopathy through the RAGE\/PXDN\/PI3K\/AKT pathway"],"prefix":"10.1186","volume":"24","author":[{"given":"Yi","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"7590_CR1","doi-asserted-by":"publisher","first-page":"111976","DOI":"10.1016\/j.celrep.2022.111976","volume":"42","author":"C Guo","year":"2023","unstructured":"Guo C, Deshpande M, Niu Y, Kachwala I, Flores-Bellver M, Megarity H, et al. HIF-1\u03b1 accumulation in response to transient hypoglycemia May worsen diabetic eye disease. Cell Rep. 2023;42:111976.","journal-title":"Cell Rep"},{"key":"7590_CR2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11892-012-0289-0","volume":"12","author":"S Wang","year":"2012","unstructured":"Wang S, Park JK, Duh EJ. Novel targets against retinal angiogenesis in diabetic retinopathy. Curr Diab Rep. 2012;12:355\u201363.","journal-title":"Curr Diab Rep"},{"key":"7590_CR3","unstructured":"Zhen Ling T, Yih-Chung T, Marco Y, Miao Li C, Tyler Hyungtaek R, Ning C, et al. Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology. 2021;128(11)."},{"key":"7590_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/cells14050376","volume":"14","author":"H Seo","year":"2025","unstructured":"Seo H, Park S-J, Song M. Diabetic retinopathy (DR): Mechanisms, current Therapies, and emerging strategies. Cells. 2025;14:376.","journal-title":"Cells"},{"key":"7590_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S2213-8587(19)30411-5","volume":"8","author":"S Vujosevic","year":"2020","unstructured":"Vujosevic S, Aldington SJ, Silva P, Hern\u00e1ndez C, Scanlon P, Peto T, et al. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol. 2020;8:337\u201347.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"7590_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s13410-023-01272-7","volume":"44","author":"AH Mahdizade","year":"2024","unstructured":"Mahdizade AH, Bahreiny SS, Bastani M-N, Dabbagh MR, Aghaei M, Ali Malayeri F, et al. The influence of CDKAL1 (rs7754840) gene polymorphism on susceptibility to gestational diabetes mellitus in pregnant women: a systematic review and meta-analysis. Int J Diabetes Dev Ctries. 2024;44:3\u201312.","journal-title":"Int J Diabetes Dev Ctries"},{"key":"7590_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11892-021-01403-6","volume":"21","author":"LA Everett","year":"2021","unstructured":"Everett LA, Paulus YM. Laser therapy in the treatment of diabetic retinopathy and diabetic macular edema. Curr Diab Rep. 2021;21:35.","journal-title":"Curr Diab Rep"},{"key":"7590_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11892-019-1276-5","volume":"19","author":"MP Ellis","year":"2019","unstructured":"Ellis MP, Lent-Schochet D, Lo T, Yiu G. Emerging concepts in the treatment of diabetic retinopathy. Curr Diab Rep. 2019;19:137.","journal-title":"Curr Diab Rep"},{"key":"7590_CR9","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10456-024-09943-7","volume":"27","author":"Y-L Liao","year":"2024","unstructured":"Liao Y-L, Fang Y-F, Sun J-X, Dou G-R. Senescent endothelial cells: a potential target for diabetic retinopathy. Angiogenesis. 2024;27:663\u201379.","journal-title":"Angiogenesis"},{"key":"7590_CR10","doi-asserted-by":"publisher","first-page":"e70015","DOI":"10.1111\/acel.70015","volume":"24","author":"AU Gurkar","year":"2025","unstructured":"Gurkar AU, Okawa S, Guillermier C, Chaddha K, Steinhauser ML. Large-Scale clustered transcriptional Silencing associated with cellular senescence. Aging Cell. 2025;24:e70015.","journal-title":"Aging Cell"},{"key":"7590_CR11","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1089\/rej.2022.0021","volume":"25","author":"Y Pan","year":"2022","unstructured":"Pan Y, Gu Z, Lyu Y, Yang Y, Chung M, Pan X, et al. Link between senescence and cell fate: senescence-Associated secretory phenotype and its effects on stem cell fate transition. Rejuvenation Res. 2022;25:160\u201372.","journal-title":"Rejuvenation Res"},{"key":"7590_CR12","doi-asserted-by":"publisher","first-page":"e70488","DOI":"10.1002\/hsr2.70488","volume":"8","author":"M Aghaei","year":"2025","unstructured":"Aghaei M, Bahreiny SS, Zayeri ZD, Davari N, Abolhasani MM, Saki N. Evaluation of complete blood count parameters in patients with diabetes mellitus: A systematic review. Health Sci Rep. 2025;8:e70488.","journal-title":"Health Sci Rep"},{"key":"7590_CR13","doi-asserted-by":"publisher","first-page":"eaay5356","DOI":"10.1126\/science.aay5356","volume":"369","author":"F Binet","year":"2020","unstructured":"Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, et al. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science. 2020;369:eaay5356.","journal-title":"Science"},{"key":"7590_CR14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41420-024-01954-z","volume":"10","author":"D Ramini","year":"2024","unstructured":"Ramini D, Giuliani A, Kwiatkowska KM, Guescini M, Storci G, Mens\u00e0 E, et al. Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells. Cell Death Discov. 2024;10:184.","journal-title":"Cell Death Discov"},{"key":"7590_CR15","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.3390\/ijms26115211","volume":"26","author":"M Gandhi","year":"2025","unstructured":"Gandhi M, Haider S, Chang HZY, Kazlauskas A. The role of endothelial senescence in the pathogenesis of diabetic retinopathy. Int J Mol Sci. 2025;26:5211.","journal-title":"Int J Mol Sci"},{"key":"7590_CR16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tjog.2023.10.003","volume":"63","author":"SS Bahreiny","year":"2024","unstructured":"Bahreiny SS, Bastani M-N, Aghaei M, Dabbagh MR, Mahdizade AH. Circulating Galectin-3 levels in women with polycystic ovary syndrome: A meta-analysis. Taiwan J Obstet Gynecol. 2024;63:37\u201345.","journal-title":"Taiwan J Obstet Gynecol"},{"key":"7590_CR17","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","volume":"33","author":"S Crespo-Garcia","year":"2021","unstructured":"Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, et al. Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL Inhibition. Cell Metab. 2021;33:818\u2013e8327.","journal-title":"Cell Metab"},{"key":"7590_CR18","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.3389\/fphys.2019.01523","volume":"10","author":"J Sabbatinelli","year":"2019","unstructured":"Sabbatinelli J, Prattichizzo F, Olivieri F, Procopio AD, Rippo MR, Giuliani A. Where metabolism Meets senescence: focus on endothelial cells. Front Physiol. 2019;10:1523.","journal-title":"Front Physiol"},{"key":"7590_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","volume":"17","author":"DA Antonetti","year":"2021","unstructured":"Antonetti DA, Silva PS, Stitt AW. Current Understanding of the molecular and cellular pathology of diabetic retinopathy. Nat Rev Endocrinol. 2021;17:195\u2013206.","journal-title":"Nat Rev Endocrinol"},{"key":"7590_CR20","doi-asserted-by":"publisher","first-page":"1415971","DOI":"10.3389\/fphar.2024.1415971","volume":"15","author":"L Si","year":"2024","unstructured":"Si L, Lai Y. Pharmacological mechanisms by which Baicalin ameliorates cardiovascular disease. Front Pharmacol. 2024;15:1415971.","journal-title":"Front Pharmacol"},{"key":"7590_CR21","doi-asserted-by":"publisher","first-page":"9317","DOI":"10.3390\/ijms24119317","volume":"24","author":"Y Wen","year":"2023","unstructured":"Wen Y, Wang Y, Zhao C, Zhao B, Wang J. The Pharmacological efficacy of Baicalin in inflammatory diseases. Int J Mol Sci. 2023;24:9317.","journal-title":"Int J Mol Sci"},{"key":"7590_CR22","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1007\/s43032-023-01447-x","volume":"31","author":"SS Bahreiny","year":"2024","unstructured":"Bahreiny SS, Ahangarpour A, Saki N, Dabbagh MR, Ebrahimi R, Mahdizade AH, et al. Association of free radical product and polycystic ovary syndrome: A systematic review and Meta-analysis. Reprod Sci. 2024;31:1486\u201395.","journal-title":"Reprod Sci"},{"key":"7590_CR23","doi-asserted-by":"publisher","first-page":"105444","DOI":"10.1016\/j.phrs.2021.105444","volume":"165","author":"Q Hu","year":"2021","unstructured":"Hu Q, Zhang W, Wu Z, Tian X, Xiang J, Li L, et al. Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. Pharmacol Res. 2021;165:105444.","journal-title":"Pharmacol Res"},{"key":"7590_CR24","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1080\/13880209.2020.1779318","volume":"58","author":"M Xu","year":"2020","unstructured":"Xu M, Li X, Song L. Baicalin regulates macrophages polarization and alleviates myocardial ischaemia\/reperfusion injury via inhibiting JAK\/STAT pathway. Pharm Biol. 2020;58:655\u201363.","journal-title":"Pharm Biol"},{"key":"7590_CR25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.5483\/BMBRep.2015.48.5.131","volume":"48","author":"H Jo","year":"2015","unstructured":"Jo H, Jung SH, Yim HB, Lee SJ, Kang KD. The effect of Baicalin in a mouse model of retinopathy of prematurity. BMB Rep. 2015;48:271\u20136.","journal-title":"BMB Rep"},{"key":"7590_CR26","doi-asserted-by":"publisher","first-page":"1443472","DOI":"10.3389\/fphar.2024.1443472","volume":"15","author":"H Yu","year":"2024","unstructured":"Yu H, Zhou D, Wang W, Wang Q, Li M, Ma X. Protective effect of Baicalin on oxidative stress injury in retinal ganglion cells through the JAK\/STAT signaling pathway in vitro and in vivo. Front Pharmacol. 2024;15:1443472.","journal-title":"Front Pharmacol"},{"key":"7590_CR27","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s11011-014-9601-9","volume":"30","author":"C Chen","year":"2015","unstructured":"Chen C, Li X, Gao P, Tu Y, Zhao M, Li J, et al. Baicalin attenuates Alzheimer-like pathological changes and memory deficits induced by amyloid \u03b21\u201342 protein. Metab Brain Dis. 2015;30:537\u201344.","journal-title":"Metab Brain Dis"},{"key":"7590_CR28","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s12967-022-03659-2","volume":"20","author":"J Liu","year":"2022","unstructured":"Liu J, Liu M, Feng J, Zhu H, Wu J, Zhang H, et al. Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN\/HOCL\/ERK signaling pathways. J Transl Med. 2022;20:461.","journal-title":"J Transl Med"},{"key":"7590_CR29","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2022.02.026","volume":"182","author":"G Cheng","year":"2022","unstructured":"Cheng G, Shi R. Mammalian Peroxidasin (PXDN): from physiology to pathology. Free Radic Biol Med. 2022;182:100\u20137.","journal-title":"Free Radic Biol Med"},{"key":"7590_CR30","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.3390\/ijms20246144","volume":"20","author":"H-K Kim","year":"2019","unstructured":"Kim H-K, Ham KA, Lee S-W, Choi HS, Kim H-S, Kim HK, et al. Biallelic deletion of Pxdn in mice leads to anophthalmia and severe eye malformation. Int J Mol Sci. 2019;20:6144.","journal-title":"Int J Mol Sci"},{"key":"7590_CR31","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1186\/s12885-024-13097-6","volume":"24","author":"Y Tian","year":"2024","unstructured":"Tian Y, Qiu S, Yang S, Jiang Y, Hu H, Yang C, et al. The oncogenic role and prognostic value of PXDN in human stomach adenocarcinoma. BMC Cancer. 2024;24:1463.","journal-title":"BMC Cancer"},{"key":"7590_CR32","doi-asserted-by":"publisher","first-page":"116572","DOI":"10.1016\/j.biopha.2024.116572","volume":"174","author":"M-H Cheng","year":"2024","unstructured":"Cheng M-H, Kuo H-F, Chang C-Y, Chang J-C, Liu I-F, Hsieh C-C, et al. Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p\/DNMT3A axis. Biomed Pharmacother. 2024;174:116572.","journal-title":"Biomed Pharmacother"},{"key":"7590_CR33","doi-asserted-by":"publisher","first-page":"121824","DOI":"10.1016\/j.lfs.2023.121824","volume":"328","author":"Y Guo","year":"2023","unstructured":"Guo Y, Zhou A, Zhang Y, Chen Y, Chen Y, Gao Y, et al. Serum response factor activates Peroxidasin transcription to block senescence of hepatic stellate cells. Life Sci. 2023;328:121824.","journal-title":"Life Sci"},{"key":"7590_CR34","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/0955-0674(94)90090-6","volume":"6","author":"JR Potts","year":"1994","unstructured":"Potts JR, Campbell ID. Fibronectin structure and assembly. Curr Opin Cell Biol. 1994;6:648\u201355.","journal-title":"Curr Opin Cell Biol"},{"key":"7590_CR35","doi-asserted-by":"publisher","first-page":"100584","DOI":"10.1016\/j.jbc.2021.100584","volume":"296","author":"M Usuelli","year":"2021","unstructured":"Usuelli M, Meyer T, Mezzenga R, Mitsi M. VEGF and VEGFR2 bind to similar pH-sensitive sites on fibronectin, exposed by heparin-mediated conformational changes. J Biol Chem. 2021;296:100584.","journal-title":"J Biol Chem"},{"key":"7590_CR36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1161\/CIRCULATIONAHA.117.031358","volume":"138","author":"D Sawaki","year":"2018","unstructured":"Sawaki D, Czibik G, Pini M, Ternacle J, Suffee N, Mercedes R, et al. Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production. Circulation. 2018;138:809\u201322.","journal-title":"Circulation"},{"key":"7590_CR37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejphar.2018.06.001","volume":"833","author":"D Sanajou","year":"2018","unstructured":"Sanajou D, Ghorbani Haghjo A, Argani H, Aslani S. AGE-RAGE axis Blockade in diabetic nephropathy: current status and future directions. Eur J Pharmacol. 2018;833:158\u201364.","journal-title":"Eur J Pharmacol"},{"key":"7590_CR38","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/s41401-020-00538-8","volume":"42","author":"X Wang","year":"2021","unstructured":"Wang X, Chen X, Yu H, Tan Y, Lin Q, Keller BB, et al. Engineered cardiac tissues: a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy. Acta Pharmacol Sin. 2021;42:932\u201341.","journal-title":"Acta Pharmacol Sin"},{"key":"7590_CR39","doi-asserted-by":"publisher","first-page":"102031","DOI":"10.1016\/j.redox.2021.102031","volume":"45","author":"G Jing Cao, Zhang","year":"2021","unstructured":"Jing Cao, Zhang G, Liu Z, Xu Q, Li C, Cheng G, et al. Peroxidasin promotes diabetic vascular endothelial dysfunction induced by advanced glycation end products via NOX2\/HOCl\/Akt\/eNOS pathway. Redox Biol. 2021;45:102031.","journal-title":"Redox Biol"},{"key":"7590_CR40","doi-asserted-by":"publisher","first-page":"102460","DOI":"10.1016\/j.redox.2022.102460","volume":"56","author":"K Liu","year":"2022","unstructured":"Liu K, Gao X, Hu C, Gui Y, Gui S, Ni Q, et al. Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress. Redox Biol. 2022;56:102460.","journal-title":"Redox Biol"},{"key":"7590_CR41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.63.3.7","volume":"63","author":"Y-J Qin","year":"2022","unstructured":"Qin Y-J, Xiao K, Zhong Z, Zhao Y, Yu T, Sun X-F. LECT2 ameliorates Blood\u2013Retinal barrier impairment secondary to diabetes via activation of the Tie2\/Akt\/mTOR signaling pathway. Investig Opthalmology Vis Sci. 2022;63:7.","journal-title":"Investig Opthalmology Vis Sci"},{"key":"7590_CR42","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1186\/s12967-024-05287-4","volume":"22","author":"R Wang","year":"2024","unstructured":"Wang R, Xue W, Kan F, Zhang H, Wang D, Wang L, et al. NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation. J Transl Med. 2024;22:476.","journal-title":"J Transl Med"},{"key":"7590_CR43","doi-asserted-by":"publisher","first-page":"156108","DOI":"10.1016\/j.metabol.2024.156108","volume":"164","author":"J-S Kim","year":"2025","unstructured":"Kim J-S, Jun JH, Lee J, Park S, Kim E, Hwang SJ, et al. HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy. Metabolism. 2025;164:156108.","journal-title":"Metabolism"},{"key":"7590_CR44","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/jcp.29047","volume":"235","author":"N Han","year":"2020","unstructured":"Han N, Tian W, Yu N, Yu L. YAP1 is required for the angiogenesis in retinal microvascular endothelial cells via the Inhibition of MALAT1-mediated miR\u2010200b\u20103p in high glucose\u2010induced diabetic retinopathy. J Cell Physiol. 2020;235:1309\u201320.","journal-title":"J Cell Physiol"},{"key":"7590_CR45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cmet.2019.05.006","volume":"30","author":"C Aguayo-Mazzucato","year":"2019","unstructured":"Aguayo-Mazzucato C, Andle J, Lee TB, Midha A, Talemal L, Chipashvili V, et al. Acceleration of \u03b2 cell aging determines diabetes and Senolysis improves disease outcomes. Cell Metab. 2019;30:129\u2013e1424.","journal-title":"Cell Metab"},{"key":"7590_CR46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10522-011-9361-4","volume":"13","author":"HA Lim","year":"2012","unstructured":"Lim HA, Lee EK, Kim JM, Park MH, Kim DH, Choi YJ, et al. PPAR\u03b3 activation by Baicalin suppresses NF-\u03baB-mediated inflammation in aged rat kidney. Biogerontology. 2012;13:133\u201345.","journal-title":"Biogerontology"},{"key":"7590_CR47","doi-asserted-by":"publisher","first-page":"e70155","DOI":"10.1111\/acel.70155","volume":"24","author":"H Liu","year":"2025","unstructured":"Liu H, Sun L, Mi Y, Gao Y, Luo J, Kang F, et al. SIRT1 prevents lens epithelial cell senescence during Age-Related cataract via regulating p66Shc. Aging Cell. 2025;24:e70155.","journal-title":"Aging Cell"},{"key":"7590_CR48","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.2147\/DDDT.S319260","volume":"15","author":"L Ma","year":"2021","unstructured":"Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F. Baicalin alleviates oxidative stress and inflammation in diabetic nephropathy via Nrf2 and MAPK signaling pathway. Drug Des Devel Ther. 2021;15:3207\u201321.","journal-title":"Drug Des Devel Ther"},{"key":"7590_CR49","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1142\/S0192415X14500463","volume":"42","author":"W Min","year":"2014","unstructured":"Min W, Liu X, Qian Q, Lin B, Wu D, Wang M, et al. The effects of Baicalin against UVA-Induced Photoaging in skin fibroblasts. Am J Chin Med. 2014;42:709\u201327.","journal-title":"Am J Chin Med"},{"key":"7590_CR50","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.freeradbiomed.2020.04.024","volume":"155","author":"MJ Smith","year":"2020","unstructured":"Smith MJ, Fowler M, Naftalin RJ, Siow RCM. UVA irradiation increases ferrous iron release from human skin fibroblast and endothelial cell ferritin: consequences for cell senescence and aging. Free Radic Biol Med. 2020;155:49\u201357.","journal-title":"Free Radic Biol Med"},{"key":"7590_CR51","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3390\/ijms19041215","volume":"19","author":"E Shosha","year":"2018","unstructured":"Shosha E, Xu Z, Narayanan SP, Lemtalsi T, Fouda AY, Rojas M, et al. Mechanisms of Diabetes-Induced endothelial cell senescence: role of arginase 1. Int J Mol Sci. 2018;19:1215.","journal-title":"Int J Mol Sci"},{"key":"7590_CR52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2174\/138945009787122905","volume":"10","author":"K Sourris","year":"2009","unstructured":"Sourris K, Forbes J. Interactions between advanced glycation End-Products (AGE) and their receptors in the development and progression of diabetic Nephropathy \u2013 are these receptors valid therapeutic targets. Curr Drug Targets. 2009;10:42\u201350.","journal-title":"Curr Drug Targets"},{"key":"7590_CR53","doi-asserted-by":"publisher","first-page":"19891","DOI":"10.3390\/ijms141019891","volume":"14","author":"G Daffu","year":"2013","unstructured":"Daffu G, Del Pozo C, O\u2019Shea K, Ananthakrishnan R, Ramasamy R, Schmidt A. Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int J Mol Sci. 2013;14:19891\u2013910.","journal-title":"Int J Mol Sci"},{"key":"7590_CR54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2174\/138161208783597416","volume":"14","author":"S Yamagishi","year":"2008","unstructured":"Yamagishi S, Nakamura K, Matsui T, Noda Y, Imaizumi T. Receptor for advanced glycation end products (RAGE): A novel therapeutic target for diabetic vascular complication. Curr Pharm Des. 2008;14:487\u201395.","journal-title":"Curr Pharm Des"},{"key":"7590_CR55","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.exger.2010.11.007","volume":"46","author":"S Yamagishi","year":"2011","unstructured":"Yamagishi S. Role of advanced glycation end products (AGEs) and receptor for ages (RAGE) in vascular damage in diabetes. Exp Gerontol. 2011;46:217\u201324.","journal-title":"Exp Gerontol"},{"key":"7590_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0047-6374(01)00366-9","volume":"1","author":"D Stern","year":"2002","unstructured":"Stern D, Yan S, Yan S, Schmidt A. Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes. Ageing Res Rev. 2002;1:1\u201315.","journal-title":"Ageing Res Rev"},{"key":"7590_CR57","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1016\/j.bbadis.2018.08.036","volume":"1864","author":"S Rowan","year":"2018","unstructured":"Rowan S, Bejarano E, Taylor A. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochim Biophys Acta BBA - Mol Basis Dis. 2018;1864:3631\u201343.","journal-title":"Biochim Biophys Acta BBA - Mol Basis Dis"},{"key":"7590_CR58","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.18632\/aging.205664","volume":"16","author":"L Zhou","year":"2024","unstructured":"Zhou L, Zhai G, Tian G. CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN. Aging. 2024;16:5567\u201380.","journal-title":"Aging"},{"key":"7590_CR59","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/iovs.66.3.10","volume":"66","author":"D Liu","year":"2025","unstructured":"Liu D, Meng Z, Jin C, Chen F, Pu L, Wu Z, et al. Fibronectin mediates Endothelial-to-Mesenchymal transition in retina angiogenesis. Invest Ophthalmol Vis Sci. 2025;66:10.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7590_CR60","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s10238-025-01755-3","volume":"25","author":"SS Bahreiny","year":"2025","unstructured":"Bahreiny SS, Khaksar MA, Karamali N, Dabbagh MR, Hoseinnejad A, Mohammadpour Fard R, et al. Integrative regression modeling of insulin sensitivity, resistance, and beta-cell dysfunction in predicting female infertility: a cross-sectional NHANES study. Clin Exp Med. 2025;25:224.","journal-title":"Clin Exp Med"},{"key":"7590_CR61","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.freeradbiomed.2025.03.042","volume":"233","author":"H-Y Li","year":"2025","unstructured":"Li H-Y, Wang J, Xiao T, Gu Q, Fan Y, Ge P, et al. STING immune activation of microglia aggravating neurovascular unit damage in diabetic retinopathy. Free Radic Biol Med. 2025;233:86\u2013101.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"7590_CR62","first-page":"CD013775","volume":"2","author":"J Perais","year":"2023","unstructured":"Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, et al. Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy. Cochrane Database Syst Rev. 2023;2(2):CD013775.","journal-title":"Cochrane Database Syst Rev"},{"key":"7590_CR63","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s11154-008-9090-4","volume":"9","author":"SA Madsen-Bouterse","year":"2008","unstructured":"Madsen-Bouterse SA, Kowluru RA. Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord. 2008;9:315\u201327.","journal-title":"Rev Endocr Metab Disord"},{"key":"7590_CR64","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.3390\/cells11142213","volume":"11","author":"LK Stabenow","year":"2022","unstructured":"Stabenow LK, Zibrova D, Ender C, Helbing DL, Spengler K, Marx C, et al. Oxidative glucose metabolism promotes senescence in vascular endothelial cells. Cells. 2022;11:2213.","journal-title":"Cells"},{"key":"7590_CR65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/antiox7040047","volume":"7","author":"S Elshaer","year":"2018","unstructured":"Elshaer S, Lemtalsi T, El-Remessy A. High Glucose-Mediated tyrosine nitration of PI3-Kinase: A molecular switch of survival and apoptosis in endothelial cells. Antioxidants. 2018;7:47.","journal-title":"Antioxidants"},{"key":"7590_CR66","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/antiox11061037","volume":"11","author":"G Matacchione","year":"2022","unstructured":"Matacchione G, Valli D, Silvestrini A, Giuliani A, Sabbatinelli J, Giordani C, et al. Curcumin, Polydatin and Quercetin synergistic activity protects from High-Glucose-Induced inflammation and oxidative stress. Antioxidants. 2022;11:1037.","journal-title":"Antioxidants"},{"key":"7590_CR67","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1242\/dev.137075","volume":"143","author":"JSL Yu","year":"2016","unstructured":"Yu JSL, Cui W. Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination. Development. 2016;143:3050\u201360.","journal-title":"Development"},{"key":"7590_CR68","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41420-023-01717-2","volume":"9","author":"J Li","year":"2023","unstructured":"Li J, Chen K, Li X, Zhang X, Zhang L, Yang Q, et al. Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell Death Discov. 2023;9:418.","journal-title":"Cell Death Discov"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07590-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07590-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07590-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:02:45Z","timestamp":1769000565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07590-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7590"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07590-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"1 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The human studies involved in this research strictly adhered to the principles of the Declaration of Helsinki. All studies involving human participants obtained written informed consent from all participants and were approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University (Approval No.: 2025207). Animal experiments were conducted in accordance with the Association for Research in Vision and Ophthalmology (ARVO) Statement for the Use of Animals in Ophthalmic and Vision Research, and were also approved by the same ethics committee (Approval No.: 2024076).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors read and approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"95"}}