{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:00:39Z","timestamp":1774526439372,"version":"3.50.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-07655-0","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T10:25:24Z","timestamp":1771496724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous-structural bilamellar bionic scaffold for integrated regeneration of tarso-conjunctival composite tissue"],"prefix":"10.1186","volume":"24","author":[{"given":"Xing","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengling","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feixue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-6798","authenticated-orcid":false,"given":"Xusong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"issue":"5","key":"7655_CR1","doi-asserted-by":"publisher","first-page":"101407","DOI":"10.1016\/j.clae.2021.01.002","volume":"44","author":"MK Walker","year":"2021","unstructured":"Walker MK, Schornack MM, Vincent SJ. Anatomical and physiological considerations in scleral lens wear: eyelids and tear film. Cont Lens Anterior Eye. 2021;44(5):101407.","journal-title":"Cont Lens Anterior Eye"},{"key":"7655_CR2","doi-asserted-by":"publisher","first-page":"101148","DOI":"10.1016\/j.preteyeres.2022.101148","volume":"95","author":"N Di Girolamo","year":"2023","unstructured":"Di Girolamo N, Park M. Cell identity changes in ocular surface Epithelia. Prog Retin Eye Res. 2023;95:101148.","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"7655_CR3","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s40123-022-00533-8","volume":"11","author":"Y Yan","year":"2022","unstructured":"Yan Y, Fu R, Ji Q, Liu C, Yang J, Yin X, et al. Surgical strategies for eyelid defect reconstruction: a review on principles and techniques. Ophthalmol Ther. 2022;11(4):1383\u2013408.","journal-title":"Ophthalmol Ther"},{"issue":"3","key":"7655_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.cjprs.2021.09.007","volume":"3","author":"X Huang","year":"2021","unstructured":"Huang X, Ding Y, Lu L, Jin R, Di S, Yang J, et al. Biomaterials for tarsal plate reconstruction and our innovative work. Chin J Plast Reconstructive Surg. 2021;3(3):150\u201354.","journal-title":"Chin J Plast Reconstructive Surg"},{"issue":"2","key":"7655_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10561-017-9618-5","volume":"18","author":"K Jirsova","year":"2017","unstructured":"Jirsova K, Jones GLA. Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting-a review. Cell Tissue Bank. 2017;18(2):193\u2013204.","journal-title":"Cell Tissue Bank"},{"issue":"4","key":"7655_CR6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s10561-020-09848-x","volume":"21","author":"N Sabater-Cruz","year":"2020","unstructured":"Sabater-Cruz N, Figueras-Roca M, Gonz\u00e1lez Ventosa A, Padr\u00f3-Pitarch L, Tort J, Casaroli-Marano RP. Current clinical application of sclera and amniotic membrane for ocular tissue bio-replacement. Cell Tissue Bank. 2020;21(4):597\u2013603.","journal-title":"Cell Tissue Bank"},{"issue":"19","key":"7655_CR7","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1039\/C5TB00285K","volume":"3","author":"Q Gao","year":"2015","unstructured":"Gao Q, Hu B, Ning Q, Ye C, Xie J, Ye J, et al. A primary study of poly(propylene fumarate)-2-hydroxyethyl methacrylate copolymer scaffolds for tarsal plate repair and reconstruction in rabbit eyelids. J Mater Chem B. 2015;3(19):4052\u201362.","journal-title":"J Mater Chem B"},{"key":"7655_CR8","doi-asserted-by":"publisher","first-page":"1129606","DOI":"10.3389\/fmed.2023.1129606","volume":"10","author":"P Xu","year":"2023","unstructured":"Xu P, Chen P, Gao Q, Sun Y, Cao J, Wu H, et al. Azithromycin-carrying and microtubule-orientated biomimetic poly (lactic-co-glycolic acid) scaffolds for eyelid reconstruction. Front Med (Lausanne). 2023;10:1129606.","journal-title":"Front Med (Lausanne)"},{"key":"7655_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fbioe.2020.00219","volume":"8","author":"L Chen","year":"2020","unstructured":"Chen L, Yan D, Wu N, Zhang W, Yan C, Yao Q, et al. 3D-Printed poly-caprolactone scaffolds modified with biomimetic extracellular matrices for tarsal plate tissue engineering. Front Bioeng Biotechnol. 2020;8:219.","journal-title":"Front Bioeng Biotechnol"},{"key":"7655_CR10","doi-asserted-by":"crossref","unstructured":"Lee H, Park YH, Kang HJ, Lee H. Three-dimensional bioprinting of tarsal plates with adipose-derived mesenchymal stem cells: evaluation of meibomian gland reconstruction in a rat model. Biomedicines. 2024;12(11).","DOI":"10.3390\/biomedicines12112567"},{"issue":"8","key":"7655_CR11","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1039\/C9BM00431A","volume":"7","author":"P Xu","year":"2019","unstructured":"Xu P, Gao Q, Feng X, Lou L, Zhu T, Gao C, et al. A biomimetic tarso-conjunctival biphasic scaffold for eyelid reconstruction in vivo. Biomater Sci. 2019;7(8):3373\u201385.","journal-title":"Biomater Sci"},{"issue":"4","key":"7655_CR12","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1097\/PRS.0000000000005410","volume":"143","author":"PS Cottler","year":"2019","unstructured":"Cottler PS, Olenczak JB, Ning B, Seaman SA, Thuman JM, Sun N, et al. Fenestration improves acellular dermal matrix biointegration: an investigation of revascularization with photoacoustic microscopy. Plast Reconstr Surg. 2019;143(4):971\u201381.","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"7655_CR13","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.bjoms.2023.06.001","volume":"61","author":"U Rehman","year":"2023","unstructured":"Rehman U, Shemie M, Sarwar MS, Adebayo O, Brennan PA. Use of biomaterials in the reconstruction of posterior lamellar eyelid defects: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2023;61(7):464\u201374.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"7655_CR14","doi-asserted-by":"publisher","first-page":"938798","DOI":"10.3389\/fbioe.2022.938798","volume":"10","author":"X Huang","year":"2022","unstructured":"Huang X, Ding Y, Pan W, Lu L, Jin R, Liang X, et al. A Comparative study on two types of porcine acellular dermal matrix sponges prepared by thermal crosslinking and thermal-glutaraldehyde crosslinking matrix microparticles. Front Bioeng Biotechnol. 2022;10:938798.","journal-title":"Front Bioeng Biotechnol"},{"issue":"7","key":"7655_CR15","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1302\/2046-3758.107.BJR-2020-0370.R1","volume":"10","author":"H Binder","year":"2021","unstructured":"Binder H, Hoffman L, Zak L, Tiefenboeck T, Aldrian S, Albrecht C. Clinical evaluation after matrix-associated autologous chondrocyte transplantation: a comparison of four different graft types. Bone Joint Res. 2021;10(7):370\u201379.","journal-title":"Bone Joint Res"},{"issue":"5 Suppl 2","key":"7655_CR16","doi-asserted-by":"publisher","first-page":"18s","DOI":"10.1097\/PRS.0b013e31825efea6","volume":"130","author":"RM Dunn","year":"2012","unstructured":"Dunn RM. Cross-linking in biomaterials: a primer for clinicians. Plast Reconstr Surg. 2012;130(5 Suppl 2):18s\u201326s.","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"7655_CR17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tibtech.2018.10.007","volume":"37","author":"L Gu","year":"2019","unstructured":"Gu L, Shan T, Ma YX, Tay FR, Niu L. Novel biomedical applications of crosslinked collagen. Trends Biotechnol. 2019;37(5):464\u201391.","journal-title":"Trends Biotechnol"},{"key":"7655_CR18","doi-asserted-by":"publisher","first-page":"rbac053","DOI":"10.1093\/rb\/rbac053","volume":"9","author":"X Huang","year":"2022","unstructured":"Huang X, Zhu Z, Lu L, Jin R, Sun D, Luo X. Frozen bean curd-inspired xenogeneic acellular dermal matrix with triple pretreatment approach of freeze-thaw, laser drilling and ADSCs pre-culture for promoting early vascularization and integration. Regen Biomater. 2022;9:rbac053.","journal-title":"Regen Biomater"},{"issue":"6","key":"7655_CR19","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1039\/D1BM01651B","volume":"10","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang M, Cheng D, Xu S, Du C, Xie L, et al. Applications of electrospun scaffolds with enlarged pores in tissue engineering. Biomater Sci. 2022;10(6):1423\u201347.","journal-title":"Biomater Sci"},{"key":"7655_CR20","doi-asserted-by":"publisher","first-page":"114550","DOI":"10.1016\/j.colsurfb.2025.114550","volume":"250","author":"W Deng","year":"2025","unstructured":"Deng W, Yang X, Yu J, Omari-Siaw E, Xu X. Recent advances of physiochemical cues on surfaces for directing cell fates. Colloids Surf B Biointerfaces. 2025;250:114550.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"7655_CR21","doi-asserted-by":"publisher","first-page":"881523","DOI":"10.3389\/fbioe.2022.881523","volume":"10","author":"K Liu","year":"2022","unstructured":"Liu K, He Y, Lu F. Research progress on the immunogenicity and regeneration of acellular adipose matrix: a mini review. Front Bioeng Biotechnol. 2022;10:881523.","journal-title":"Front Bioeng Biotechnol"},{"issue":"15","key":"7655_CR22","doi-asserted-by":"publisher","first-page":"8572","DOI":"10.1021\/acsomega.9b04421","volume":"5","author":"Y Ji","year":"2020","unstructured":"Ji Y, Yang X, Ji Z, Zhu L, Ma N, Chen D, et al. DFT-Calculated IR spectrum amide I, II, and III band contributions of N-methylacetamide fine components. ACS Omega. 2020;5(15):8572\u201378.","journal-title":"ACS Omega"},{"key":"7655_CR23","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1016\/j.ijbiomac.2021.05.189","volume":"182","author":"X Zheng","year":"2021","unstructured":"Zheng X, Chen Y, Dan N, Dan W, Li Z. Highly stable collagen scaffolds crosslinked with an epoxidized natural polysaccharide for wound healing. Int J Biol Macromol. 2021;182:1994\u20132002.","journal-title":"Int J Biol Macromol"},{"issue":"Pt 1","key":"7655_CR24","doi-asserted-by":"publisher","first-page":"131688","DOI":"10.1016\/j.ijbiomac.2024.131688","volume":"268","author":"C Meng","year":"2024","unstructured":"Meng C, Liu X, Li R, Malekmohammadi S, Feng Y, Song J, et al. 3D Poly (L-lactic acid) fibrous sponge with interconnected porous structure for bone tissue scaffold. Int J Biol Macromol. 2024;268(Pt 1):131688.","journal-title":"Int J Biol Macromol"},{"issue":"28","key":"7655_CR25","doi-asserted-by":"publisher","first-page":"6729","DOI":"10.1016\/j.biomaterials.2011.05.065","volume":"32","author":"J Rnjak-Kovacina","year":"2011","unstructured":"Rnjak-Kovacina J, Wise SG, Li Z, Maitz PK, Young CJ, Wang Y, et al. Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering. Biomaterials. 2011;32(28):6729\u201336.","journal-title":"Biomaterials"},{"issue":"18","key":"7655_CR26","doi-asserted-by":"publisher","first-page":"e2100644","DOI":"10.1002\/adhm.202100644","volume":"10","author":"AJ Seymour","year":"2021","unstructured":"Seymour AJ, Shin S, Heilshorn SC. 3D printing of microgel scaffolds with tunable void fraction to promote cell infiltration. Adv Healthc Mater. 2021;10(18):e2100644.","journal-title":"Adv Healthc Mater"},{"key":"7655_CR27","doi-asserted-by":"crossref","unstructured":"Pais AI, Belinha J, Alves JL. Advances in computational techniques for bio-inspired cellular materials in the field of biomechanics: current trends and prospects. Materials (Basel). 2023;16(11).","DOI":"10.3390\/ma16113946"},{"issue":"12","key":"7655_CR28","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1016\/j.jbiomech.2015.05.037","volume":"48","author":"MT Sun","year":"2015","unstructured":"Sun MT, Pham DT, O\u2019Connor AJ, Wood J, Casson R, Selva D, et al. The Biomechanics of eyelid tarsus tissue. J Biomech. 2015;48(12):3455\u201359.","journal-title":"J Biomech"},{"issue":"1","key":"7655_CR29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s13046-023-02934-4","volume":"42","author":"R Melchionna","year":"2023","unstructured":"Melchionna R, Trono P, Di Carlo A, Di Modugno F, Nistic\u00f2 P. Transcription factors in fibroblast plasticity and caf heterogeneity. J Exp Clin Cancer Res. 2023;42(1):347.","journal-title":"J Exp Clin Cancer Res"},{"key":"7655_CR30","doi-asserted-by":"publisher","first-page":"122078","DOI":"10.1016\/j.biomaterials.2023.122078","volume":"296","author":"A Pattnaik","year":"2023","unstructured":"Pattnaik A, Sanket AS, Pradhan S, Sahoo R, Das S, Pany S, et al. Designing of gradient scaffolds and their applications in tissue regeneration. Biomaterials. 2023;296:122078.","journal-title":"Biomaterials"},{"issue":"9","key":"7655_CR31","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41401-020-0381-y","volume":"41","author":"BY Zhou","year":"2020","unstructured":"Zhou BY, Wang WB, Wu XL, Zhang WJ, Zhou GD, Gao Z, et al. Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization. Acta Pharmacol Sin. 2020;41(9):1234\u201345.","journal-title":"Acta Pharmacol Sin"},{"issue":"7","key":"7655_CR32","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1016\/j.apsb.2025.04.020","volume":"15","author":"J Cheng","year":"2025","unstructured":"Cheng J, Chen Z, Lin D, Yang Y, Bai Y, Wang L, et al. A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers. Acta Pharm Sin B. 2025;15(7):3767\u201387.","journal-title":"Acta Pharm Sin B"},{"key":"7655_CR33","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.actbio.2024.09.052","volume":"189","author":"H Alkazemi","year":"2024","unstructured":"Alkazemi H, Mitchell GM, Lokmic-Tomkins Z, Heath DE, O\u2019Connor AJ. Hierarchically vascularized and suturable tissue constructs created through angiogenesis from tissue-engineered vascular grafts. Acta Biomater. 2024;189:168\u201378.","journal-title":"Acta Biomater"},{"issue":"10","key":"7655_CR34","doi-asserted-by":"publisher","first-page":"e2105152","DOI":"10.1002\/advs.202105152","volume":"9","author":"R Li","year":"2022","unstructured":"Li R, Liu K, Huang X, Li D, Ding J, Liu B, et al. Bioactive materials promote wound healing through modulation of cell behaviors. Adv Sci (Weinh). 2022;9(10):e2105152.","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"7655_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/02713683.2020.1712423","volume":"45","author":"M Borrelli","year":"2020","unstructured":"Borrelli M, Geerling G, Spaniol K, Witt J. Eye socket regeneration and reconstruction. Curr Eye Res. 2020;45(3):253\u201364.","journal-title":"Curr Eye Res"},{"issue":"8","key":"7655_CR36","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1167\/iovs.09-5108","volume":"51","author":"S Liu","year":"2010","unstructured":"Liu S, Hatton MP, Khandelwal P, Sullivan DA. Culture, immortalization, and characterization of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci. 2010;51(8):3993\u20134005.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"7655_CR37","doi-asserted-by":"publisher","first-page":"7417","DOI":"10.1167\/iovs.13-12916","volume":"54","author":"SH Brown","year":"2013","unstructured":"Brown SH, Kunnen CM, Duchoslav E, Dolla NK, Kelso MJ, Papas EB, et al. A comparison of patient matched meibum and tear lipidomes. Invest Ophthalmol Vis Sci. 2013;54(12):7417\u201324.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"7655_CR38","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.exer.2018.02.009","volume":"170","author":"X Han","year":"2018","unstructured":"Han X, Liu Y, Kam WR, Sullivan DA. Effect of brimonidine, an \u03b12 adrenergic agonist, on human meibomian gland epithelial cells. Exp Eye Res. 2018;170:20\u201328.","journal-title":"Exp Eye Res"},{"issue":"6","key":"7655_CR39","doi-asserted-by":"publisher","first-page":"e0128096","DOI":"10.1371\/journal.pone.0128096","volume":"10","author":"U Hampel","year":"2015","unstructured":"Hampel U, Schr\u00f6der A, Mitchell T, Brown S, Snikeris P, Garreis F, et al. Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line. PLoS One. 2015;10(6):e0128096.","journal-title":"PLoS One"},{"issue":"2","key":"7655_CR40","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1021\/am302272k","volume":"5","author":"J Qiu","year":"2013","unstructured":"Qiu J, Li J, Wang G, Zheng L, Ren N, Liu H, et al. In vitro investigation on the biodegradability and biocompatibility of genipin cross-linked porcine acellular dermal matrix with intrinsic fluorescence. ACS Appl Mater Interface. 2013;5(2):344\u201350.","journal-title":"ACS Appl Mater Interface"},{"key":"7655_CR41","doi-asserted-by":"crossref","unstructured":"Wen N, Qian E, Kang Y. Effects of macro-\/micro-channels on vascularization and immune response of tissue engineering scaffolds. Cells. 2021;10(6).","DOI":"10.3390\/cells10061514"},{"key":"7655_CR42","doi-asserted-by":"publisher","first-page":"0071","DOI":"10.34133\/bmr.0071","volume":"28","author":"Y Ostadi","year":"2024","unstructured":"Ostadi Y, Khanali J, Tehrani FA, Yazdanpanah G, Bahrami S, Niazi F, et al. Decellularized extracellular matrix scaffolds for soft tissue augmentation: from host-scaffold interactions to bottlenecks in clinical translation. Biomater Res. 2024;28:0071.","journal-title":"Biomater Res"},{"issue":"4","key":"7655_CR43","doi-asserted-by":"publisher","first-page":"20210043","DOI":"10.1002\/EXP.20210043","volume":"3","author":"Y Peng","year":"2023","unstructured":"Peng Y, Zhuang Y, Liu Y, Le H, Li D, Zhang M, et al. Bioinspired gradient scaffolds for osteochondral tissue engineering. Exploration (Beijing). 2023;3(4):20210043.","journal-title":"Exploration (beijing)"},{"key":"7655_CR44","doi-asserted-by":"crossref","unstructured":"Cao W, Zhang Y, Li L, Liu B, Ding J, Chen X. Physical cues of scaffolds promote peripheral nerve regeneration. Appl Phys Rev. 2024;11(2).","DOI":"10.1063\/5.0189181"},{"issue":"15","key":"7655_CR45","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1039\/D0CS00103A","volume":"49","author":"M Rahmati","year":"2020","unstructured":"Rahmati M, Silva EA, Reseland JE, Ah C, Haugen HJ. Biological responses to physicochemical properties of biomaterial surface. Chem Soc Rev. 2020;49(15):5178\u2013224.","journal-title":"Chem Soc Rev"},{"issue":"1","key":"7655_CR46","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1089\/jop.2021.0050","volume":"38","author":"W Huang","year":"2022","unstructured":"Huang W, Huang L, Li W, Saglam MS, Tourmouzis K, Goldstein SM, et al. Once-daily topical phosphosulindac is efficacious in the treatment of dry eye disease: studies in rabbit models of its main clinical subtypes. J Ocul Pharmacol Ther. 2022;38(1):102\u201313.","journal-title":"J Ocul Pharmacol Ther"},{"key":"7655_CR47","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jtos.2025.05.006","volume":"37","author":"R Shi","year":"2025","unstructured":"Shi R, Jin M, Jin J, Xu L, Liu Z, Zheng L, et al. Retinoic acid promotes conjunctival epithelium differentiation and goblet cell regeneration: evidence from novel 3D conjunctival organoids and whole-mount PAS staining. Ocul Surf. 2025;37:301\u201313.","journal-title":"Ocul Surf"},{"key":"7655_CR48","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jtos.2023.08.005","volume":"30","author":"L Xu","year":"2023","unstructured":"Xu L, Wang G, Shi R, Zeng B, Zhang Y, Liu Z, et al. A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells. Ocul Surf. 2023;30:107\u201318.","journal-title":"Ocul Surf"},{"key":"7655_CR49","doi-asserted-by":"publisher","first-page":"121786","DOI":"10.1016\/j.biomaterials.2022.121786","volume":"289","author":"M Brown","year":"2022","unstructured":"Brown M, Li J, Moraes C, Tabrizian M, Li-Jessen NYK. Decellularized extracellular matrix: new promising and challenging biomaterials for regenerative medicine. Biomaterials. 2022;289:121786.","journal-title":"Biomaterials"},{"issue":"1","key":"7655_CR50","doi-asserted-by":"publisher","first-page":"20210170","DOI":"10.1002\/EXP.20210170","volume":"3","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xu Y, Kong H, Zhang J, Chan HF, Wang J, et al. Microneedle system for tissue engineering and regenerative medicine. Exploration (Beijing). 2023;3(1):20210170.","journal-title":"Exploration (beijing)"},{"key":"7655_CR51","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jtos.2024.03.003","volume":"32","author":"J Bu","year":"2024","unstructured":"Bu J, Guo Y, Wu Y, Zhang R, Zhuang J, Zhao J, et al. Models for meibomian gland dysfunction: in vivo and in vitro. Ocul Surf. 2024;32:154\u201365.","journal-title":"Ocul Surf"},{"key":"7655_CR52","doi-asserted-by":"crossref","unstructured":"Butovich IA, Wilkerson A. Dynamic changes in the Gene expression patterns and lipid profiles in the developing and maturing meibomian glands. Int J Mol Sci. 2022;23(14).","DOI":"10.3390\/ijms23147884"},{"key":"7655_CR53","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jtos.2021.11.012","volume":"23","author":"MAT Phan","year":"2022","unstructured":"Phan MAT, Madigan MC, Stapleton F, Willcox M, Golebiowski B. Human meibomian gland epithelial cell culture models: current progress, challenges, and future directions. Ocul Surf. 2022;23:96\u2013113.","journal-title":"Ocul Surf"},{"key":"7655_CR54","doi-asserted-by":"publisher","first-page":"109851","DOI":"10.1016\/j.exer.2024.109851","volume":"241","author":"R Liu","year":"2024","unstructured":"Liu R, Tu M, Xue J, Xiao B, Li J, Liang L. Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells. Exp Eye Res. 2024;241:109851.","journal-title":"Exp Eye Res"},{"issue":"5","key":"7655_CR55","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.63.5.6","volume":"63","author":"R Liu","year":"2022","unstructured":"Liu R, Li J, Xu Y, Chen Z, Ye H, Tang J, et al. Melatonin attenuates LPS-Induced proinflammatory cytokine response and lipogenesis in human meibomian gland epithelial cells via MAPK\/NF-\u03baB pathway. Invest Ophthalmol Vis Sci. 2022;63(5):6.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"7655_CR56","doi-asserted-by":"publisher","first-page":"Des192","DOI":"10.1167\/iovs.17-23651","volume":"59","author":"T Yamaguchi","year":"2018","unstructured":"Yamaguchi T. Inflammatory response in dry eye. Invest Ophthalmol Vis Sci. 2018;59(14):Des192\u2013Des9.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"7655_CR57","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3346\/jkms.2011.26.7.938","volume":"26","author":"MH Kang","year":"2011","unstructured":"Kang MH, Kim MK, Lee HJ, Lee HI, Wee WR, Lee JH. Interleukin-17 in various ocular surface inflammatory diseases. J Korean Med Sci. 2011;26(7):938\u201344.","journal-title":"J Korean Med Sci"},{"issue":"29","key":"7655_CR58","doi-asserted-by":"publisher","first-page":"7512","DOI":"10.1016\/j.biomaterials.2010.06.044","volume":"31","author":"J Zhou","year":"2010","unstructured":"Zhou J, Peng SW, Wang YY, Zheng SB, Wang Y, Chen GQ. The use of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tarsal repair in eyelid reconstruction in the rat. Biomaterials. 2010;31(29):7512\u201318.","journal-title":"Biomaterials"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-07655-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07655-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-07655-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:02:26Z","timestamp":1774522946000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-07655-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7655"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-07655-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Tissues were harvested from patients who provided written informed consent with ethics approval from the Ethics Committee (No.SH9H-2020-T341-2). All animal protocols were permitted by the Ethics Committee of Shanghai Ninth People\u2019s Hospital (No.SH9H-2023-A886-1) and performed in accordance with the guidelines of the National Institutes of Health Guide for the Care and Use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have no financial interest to declare in relation to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"420"}}