{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:11:51Z","timestamp":1784171511770,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171024"],"award-info":[{"award-number":["82171024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-07771-5","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:37:18Z","timestamp":1772098638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting lactylation in a novel metabolic-epigenetic-inflammatory axis mitigates inflammation and promotes healing following corneal injury"],"prefix":"10.1186","volume":"24","author":[{"given":"Yi","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-4222","authenticated-orcid":false,"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"issue":"1","key":"7771_CR1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3928\/1081597X-20191203-01","volume":"36","author":"RF Oliveira","year":"2020","unstructured":"Oliveira RF, et al. Transepithelial surface ablation with mitomycin C for the treatment of chronic central corneal scars following adenoviral keratoconjunctivitis. J Refract Surg. 2020;36(1):55\u201361.","journal-title":"J Refract Surg"},{"issue":"3","key":"7771_CR2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1167\/iovs.64.3.34","volume":"64","author":"X Yang","year":"2023","unstructured":"Yang X, et al. IFN-\u03b3 facilitates corneal epithelial cell pyroptosis through the JAK2\/STAT1 pathway in dry eye. Investig Ophthalmol Vis Sci. 2023;64(3):34.","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"9","key":"7771_CR3","first-page":"CD009379","volume":"9","author":"G Clare","year":"2022","unstructured":"Clare G, Bunce C, Tuft S. Amniotic membrane transplantation for acute ocular burns. Cochrane Database Syst Rev. 2022;9(9):CD009379.","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"7771_CR4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.survophthal.2017.09.005","volume":"63","author":"N Sharma","year":"2018","unstructured":"Sharma N, et al. Treatment of acute ocular chemical burns. Surv Ophthalmol. 2018;63(2):214\u201335.","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"7771_CR5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu X, et al. The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6(1):402.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"7771_CR6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.4A1015-483R","volume":"100","author":"PR Taylor","year":"2016","unstructured":"Taylor PR, et al. JAK\/STAT regulation of Aspergillus fumigatus corneal infections and IL-6\/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016;100(1):213\u201322.","journal-title":"J Leukoc Biol"},{"issue":"14","key":"7771_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1167\/iovs.61.14.24","volume":"61","author":"F Han","year":"2020","unstructured":"Han F, et al. TSLP produced by Aspergillus fumigatus-Stimulated DCs promotes a Th17 response through the JAK\/STAT signaling pathway in fungal keratitis. Investig Ophthalmol Vis Sci. 2020;61(14):24.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"7771_CR8","doi-asserted-by":"crossref","unstructured":"Guo C, et al. The potential inhibitory effects of miR-19b on ocular inflammation are mediated upstream of the JAK\/STAT pathway in a murine model of allergic conjunctivitis. Invest Ophthalmol Visual Sci. 2020;61:8.","DOI":"10.1167\/iovs.61.3.8"},{"issue":"1","key":"7771_CR9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1172\/JCI71488","volume":"124","author":"N Takahiro","year":"2014","unstructured":"Takahiro N. LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis. J Clin Investig. 2014;124(1):385\u201397.","journal-title":"J Clin Investig"},{"issue":"2","key":"7771_CR10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tig.2021.06.014","volume":"38","author":"RL Kan","year":"2022","unstructured":"Kan RL, Chen J, Sallam T. Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation. Trends Genet. 2022;38(2):182\u201393.","journal-title":"Trends Genet"},{"issue":"7608","key":"7771_CR11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18298","volume":"534","author":"X Wang","year":"2016","unstructured":"Wang X, et al. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature. 2016;534(7608):575\u20138.","journal-title":"Nature"},{"key":"7771_CR12","doi-asserted-by":"crossref","unstructured":"Han X et al. m6A-modified circSTX6 as a key regulator of cervical cancer malignancy via SPI1 and IL6\/JAK2\/STAT3 pathways. Oncogene. 2025.","DOI":"10.1038\/s41388-024-03260-5"},{"issue":"7667","key":"7771_CR13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature23450","volume":"548","author":"H-B Li","year":"2017","unstructured":"Li H-B, et al. m6A mRNA methylation controls T cell homeostasis by targeting the IL-7\/STAT5\/SOCS pathways. Nature. 2017;548(7667):338\u201342.","journal-title":"Nature"},{"issue":"11","key":"7771_CR14","first-page":"pe2412123","volume":"12","author":"Q Yao","year":"2025","unstructured":"Yao Q, et al. METTL3 potentiates M2 Macrophage-Driven MMT to aggravate renal allograft fibrosis via the TGF-\u03b21\/Smad3 pathway. Adv Sci (Weinheim Baden-Wurttemberg Germany). 2025;12(11):pe2412123.","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"issue":"13","key":"7771_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/iovs.65.13.9","volume":"65","author":"Y Jing","year":"2024","unstructured":"Jing Y, et al. Silencing METTL3 increases HSP70 expression and alleviates fibrosis in keratocytes. Investig Ophthalmol Vis Sci. 2024;65(13):9.","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"7771_CR16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ame2.12192","volume":"4","author":"K Pang","year":"2021","unstructured":"Pang K, Lennikov A, Yang M. Hypoxia adaptation in the cornea: current animal models and underlying mechanisms. Anim Model Exp Med. 2021;4(4):300\u201310.","journal-title":"Anim Model Exp Med"},{"key":"7771_CR17","doi-asserted-by":"crossref","first-page":"841267","DOI":"10.3389\/fphar.2022.841267","volume":"13","author":"P Wang","year":"2022","unstructured":"Wang P, et al. Targeting HMGB1-NF\u03bab axis and miR-21 by glycyrrhizin: role in amelioration of corneal injury in a mouse model of alkali burn. Front Pharmacol. 2022;13:841267.","journal-title":"Front Pharmacol"},{"issue":"1","key":"7771_CR18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s40123-018-0125-y","volume":"7","author":"M Moshirfar","year":"2018","unstructured":"Moshirfar M, et al. Ultramarathon-Induced bilateral corneal edema: A case report and a review of the literature. Ophthalmol Ther. 2018;7(1):197\u2013202.","journal-title":"Ophthalmol Ther"},{"key":"7771_CR19","doi-asserted-by":"crossref","first-page":"103194","DOI":"10.1016\/j.redox.2024.103194","volume":"74","author":"D Wu","year":"2024","unstructured":"Wu D, et al. Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury. Redox Biol. 2024;74:103194.","journal-title":"Redox Biol"},{"issue":"7779","key":"7771_CR20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574(7779):575\u201380.","journal-title":"Nature"},{"issue":"3","key":"7771_CR21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cmet.2023.12.023","volume":"36","author":"X Lin","year":"2024","unstructured":"Lin X, et al. Augmentation of scleral Glycolysis promotes myopia through histone lactylation. Cell Metab. 2024;36(3):511\u2013e5257.","journal-title":"Cell Metab"},{"issue":"2","key":"7771_CR22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","volume":"16","author":"X Chen","year":"2024","unstructured":"Chen X, et al. Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. EMBO Mol Med. 2024;16(2):294\u2013318.","journal-title":"EMBO Mol Med"},{"issue":"5","key":"7771_CR23","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1093\/nar\/gkad1193","volume":"52","author":"X Gu","year":"2024","unstructured":"Gu X, et al. Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A. Nucleic Acids Res. 2024;52(5):2273\u201389.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"7771_CR24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s10020-025-01173-x","volume":"31","author":"J Zhou","year":"2025","unstructured":"Zhou J, et al. METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2. Mol Med. 2025;31(1):118.","journal-title":"Mol Med"},{"issue":"6","key":"7771_CR25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.33549\/physiolres.935289","volume":"73","author":"J Meng","year":"2024","unstructured":"Meng J, Yan C, Liu J. LDHA- mediated histone lactylation promotes the nonalcoholic fatty liver disease progression through targeting the METTL3\/ YTHDF1\/SCD1 m6A axis. Physiol Res. 2024;73(6):985\u201399.","journal-title":"Physiol Res"},{"issue":"1","key":"7771_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","volume":"22","author":"J Yu","year":"2021","unstructured":"Yu J, et al. Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol. 2021;22(1):85.","journal-title":"Genome Biol"},{"issue":"9","key":"7771_CR27","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.molcel.2022.02.033","volume":"82","author":"J Xiong","year":"2022","unstructured":"Xiong J, et al. Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells. Mol Cell. 2022;82(9):1660\u2013e167710.","journal-title":"Mol Cell"},{"issue":"3","key":"7771_CR28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000268009","volume":"29","author":"C Laria","year":"1997","unstructured":"Laria C, Ali\u00f3 JL, Ruiz-Moreno JM. Combined non-steroidal therapy in experimental corneal injury. Ophthalmic Res. 1997;29(3):145\u201353.","journal-title":"Ophthalmic Res"},{"key":"7771_CR29","doi-asserted-by":"crossref","first-page":"106468","DOI":"10.1016\/j.intimp.2020.106468","volume":"83","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, et al. Blockade of extracellular high-mobility group box 1 attenuates inflammation-mediated damage and haze grade in mice with corneal wounds. Int Immunopharmacol. 2020;83:106468.","journal-title":"Int Immunopharmacol"},{"issue":"3613","key":"7771_CR30","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.143.3613.1457","volume":"143","author":"G Broder","year":"1964","unstructured":"Broder G, Weil MH. EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTS. Science. 1964;143(3613):1457\u20139.","journal-title":"Science"},{"issue":"34","key":"7771_CR31","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","volume":"25","author":"H Pelicano","year":"2006","unstructured":"Pelicano H, et al. Glycolysis Inhibition for anticancer treatment. Oncogene. 2006;25(34):4633\u201346.","journal-title":"Oncogene"},{"issue":"5\u20136","key":"7771_CR32","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1007\/s10495-025-02109-w","volume":"30","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, et al. Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting Glycolysis. Apoptosis. 2025;30(5\u20136):1440\u201352.","journal-title":"Apoptosis"},{"key":"7771_CR33","doi-asserted-by":"crossref","unstructured":"Qiao J et al. Histone H3K18 and Ezrin lactylation promote renal dysfunction in sepsis-associated acute kidney injury. Adv Sci (Weinh). 2024;e2307216.","DOI":"10.1002\/advs.202307216"},{"issue":"1","key":"7771_CR34","doi-asserted-by":"crossref","first-page":"10772","DOI":"10.1038\/s41598-025-93313-w","volume":"15","author":"M Sun","year":"2025","unstructured":"Sun M, et al. PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la\/ NF-\u03baB induced neuroinflammation and mitochondrial damage. Sci Rep. 2025;15(1):10772.","journal-title":"Sci Rep"},{"key":"7771_CR35","doi-asserted-by":"crossref","first-page":"116879","DOI":"10.1016\/j.bcp.2025.116879","volume":"236","author":"S Ge","year":"2025","unstructured":"Ge S, et al. Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation. Biochem Pharmacol. 2025;236:116879.","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"7771_CR36","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","volume":"35","author":"H Rho","year":"2023","unstructured":"Rho H, et al. Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis. Cell Metab. 2023;35(8):1406\u2013e14238.","journal-title":"Cell Metab"},{"key":"7771_CR37","doi-asserted-by":"crossref","first-page":"1221609","DOI":"10.3389\/fimmu.2023.1221609","volume":"14","author":"B Song","year":"2023","unstructured":"Song B, et al. Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications. Front Immunol. 2023;14:1221609.","journal-title":"Front Immunol"},{"issue":"7","key":"7771_CR38","doi-asserted-by":"crossref","first-page":"e52774","DOI":"10.15252\/embr.202152774","volume":"22","author":"S Nitsch","year":"2021","unstructured":"Nitsch S, Zorro L, Shahidian, Schneider R. Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism. EMBO Rep. 2021;22(7):e52774.","journal-title":"EMBO Rep"},{"key":"7771_CR39","doi-asserted-by":"crossref","first-page":"786666","DOI":"10.3389\/fimmu.2021.786666","volume":"12","author":"X Chu","year":"2021","unstructured":"Chu X, et al. Lactylated histone H3K18 as a potential biomarker for the diagnosis and predicting the severity of septic shock. Front Immunol. 2021;12:786666.","journal-title":"Front Immunol"},{"issue":"1","key":"7771_CR40","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s11033-025-10976-4","volume":"52","author":"L Yang","year":"2025","unstructured":"Yang L, et al. A systematic review of protein post-translational modifications in sepsis. Mol Biol Rep. 2025;52(1):865.","journal-title":"Mol Biol Rep"},{"key":"7771_CR41","doi-asserted-by":"crossref","first-page":"1284344","DOI":"10.3389\/fimmu.2023.1284344","volume":"14","author":"J Qu","year":"2023","unstructured":"Qu J, Li P, Sun Z. Histone lactylation regulates cancer progression by reshaping the tumor microenvironment. Front Immunol. 2023;14:1284344.","journal-title":"Front Immunol"},{"issue":"1","key":"7771_CR42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41420-025-02334-x","volume":"11","author":"Y Xu","year":"2025","unstructured":"Xu Y, et al. Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis. Cell Death Discov. 2025;11(1):54.","journal-title":"Cell Death Discov"},{"issue":"6","key":"7771_CR43","first-page":"471","volume":"27","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Cao L, Xu K. [Role and mechanism of lactylation in Cancer]. Zhongguo Fei Ai Za Zhi. 2024;27(6):471\u20139.","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"7771_CR44","doi-asserted-by":"crossref","unstructured":"Tang Y, et al. Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation. cell death and differentiation. 2025.","DOI":"10.1038\/s41418-025-01554-z"},{"issue":"46","key":"7771_CR45","doi-asserted-by":"crossref","first-page":"e2401399","DOI":"10.1002\/advs.202401399","volume":"11","author":"Y Lu","year":"2024","unstructured":"Lu Y, et al. Lactylation-Driven IGF2BP3-Mediated Serine metabolism reprogramming and RNA m6A-Modification promotes lenvatinib resistance in HCC. Adv Sci (Weinh). 2024;11(46):e2401399.","journal-title":"Adv Sci (Weinh)"},{"issue":"28","key":"7771_CR46","doi-asserted-by":"crossref","first-page":"e2309840","DOI":"10.1002\/advs.202309840","volume":"11","author":"B Chen","year":"2024","unstructured":"Chen B, et al. Metabolic recoding of NSUN2-Mediated m(5)C modification promotes the progression of colorectal cancer via the NSUN2\/YBX1\/m(5)C-ENO1 positive feedback loop. Adv Sci (Weinh). 2024;11(28):e2309840.","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"7771_CR47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41419-024-06509-9","volume":"15","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, et al. The m(6)A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis. Cell Death Dis. 2024;15(3):189.","journal-title":"Cell Death Dis"},{"issue":"640","key":"7771_CR48","doi-asserted-by":"crossref","first-page":"eabk2709","DOI":"10.1126\/scitranslmed.abk2709","volume":"14","author":"JN Wang","year":"2022","unstructured":"Wang JN, et al. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating table 3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med. 2022;14(640):eabk2709.","journal-title":"Sci Transl Med"},{"issue":"21","key":"7771_CR49","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","volume":"185","author":"RL Philips","year":"2022","unstructured":"Philips RL, et al. The JAK-STAT pathway at 30: much learned, much more to do. Cell. 2022;185(21):3857\u201376.","journal-title":"Cell"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-07771-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07771-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07771-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:01:52Z","timestamp":1774972912000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-07771-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7771"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-07771-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All mouse experiments were implemented in accordance with the Association for Research in Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Vision Research. All animal experiments were approved by the Experimental Animal Management Organization of the Nankai Center in Tianjin (approval no. NKYY-DWLL-2023-052).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have reviewed and approved the final version of the manuscript for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No conflict of interest was declared by the authors.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"452"}}