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The study was approved by the Ethics Committee of Tongji Hospital (Approval No. TJ-IRB202505059). Written informed consent was obtained from all participants. Animal experiments were performed at the Laboratory Animal Center of Tongji Hospital, Wuhan, China. The animals were housed in an SPF barrier facility. All procedures followed the National Guidelines for the Care and Use of Laboratory Animals of China. Ethical approval was granted by the Ethics Committee of the Laboratory Animal Center of Tongji Hospital (Approval No. TJH-202501031). Animals were purchased from Wuhan Norming Biotechnology Co., Ltd. and had free access to food and water.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This study did not include any individual person\u2019s identifiable data, images, or case reports. Only anonymized tissue samples and clinical measurements were used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"418"}}