{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:52:27Z","timestamp":1794379947667,"version":"4.9.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2024206476"],"award-info":[{"award-number":["H2024206476"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Science Research Project of Hebei","award":["20241174"],"award-info":[{"award-number":["20241174"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-07875-y","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:24:05Z","timestamp":1771493045000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glutamine-mediated crosstalk between M2 macrophages and tumor cells via the SLC38A5\/FOXM1\/CNIH4 axis promotes oral squamous cell carcinoma progression"],"prefix":"10.1186","volume":"24","author":[{"given":"Yuanhang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-815X","authenticated-orcid":false,"given":"Yongle","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"7875_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6:92.","journal-title":"Nat Rev Dis Primers"},{"key":"7875_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","volume":"15","author":"Y Tan","year":"2023","unstructured":"Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023;15:44.","journal-title":"Int J Oral Sci"},{"key":"7875_CR3","doi-asserted-by":"crossref","unstructured":"Arboleda LPA, de Carvalho GB, Santos-Silva AR, Fernandes GA, Vartanian JG, Conway DI, Virani S, Brennan P, Kowalski LP, Curado MP. Squamous cell carcinoma of the oral cavity, oropharynx, and larynx: a scoping review of treatment guidelines worldwide. Cancers (Basel). 2023;15.","DOI":"10.3390\/cancers15174405"},{"key":"7875_CR4","doi-asserted-by":"crossref","unstructured":"Tomita H, Yamashiro T, Heianna J, Nakasone T, Kobayashi T, Mishiro S, Hirahara D, Takaya E, Mimura H, Murayama S, Kobayashi Y. Deep learning for the preoperative diagnosis of metastatic cervical lymph nodes on contrast-enhanced computed tomography in patients with oral squamous cell carcinoma. Cancers (Basel). 2021;13.","DOI":"10.3390\/cancers13040600"},{"key":"7875_CR5","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12943-024-02064-1","volume":"23","author":"X Chu","year":"2024","unstructured":"Chu X, Tian Y, Lv C. Decoding the Spatiotemporal heterogeneity of tumor-associated macrophages. Mol Cancer. 2024;23:150.","journal-title":"Mol Cancer"},{"key":"7875_CR6","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.7150\/thno.51777","volume":"11","author":"D Chen","year":"2021","unstructured":"Chen D, Zhang X, Li Z, Zhu B. Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages. Theranostics. 2021;11:1016\u201330.","journal-title":"Theranostics"},{"key":"7875_CR7","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","volume":"79","author":"DC Hinshaw","year":"2019","unstructured":"Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79:4557\u201366.","journal-title":"Cancer Res"},{"key":"7875_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13046-020-01786-6","volume":"40","author":"W Fang","year":"2021","unstructured":"Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, Zeng Q, Wang Y, Jin F, Chai C, Chen T. Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8(+) T cell exclusion. J Exp Clin Cancer Res. 2021;40:4.","journal-title":"J Exp Clin Cancer Res"},{"key":"7875_CR9","doi-asserted-by":"crossref","unstructured":"Yahaya MAF, Lila MAM, Ismail S, Zainol M, Afizan N. Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them. J Immunol Res. 2019;2019:2368249.","DOI":"10.1155\/2019\/2368249"},{"key":"7875_CR10","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/1878-0261.12644","volume":"14","author":"H Dan","year":"2020","unstructured":"Dan H, Liu S, Liu J, Liu D, Yin F, Wei Z, Wang J, Zhou Y, Jiang L, Ji N, et al. RACK1 promotes cancer progression by increasing the M2\/M1 macrophage ratio via the NF-kappaB pathway in oral squamous cell carcinoma. Mol Oncol. 2020;14:795\u2013807.","journal-title":"Mol Oncol"},{"key":"7875_CR11","doi-asserted-by":"publisher","first-page":"110972","DOI":"10.1016\/j.intimp.2023.110972","volume":"124","author":"Y Lin","year":"2023","unstructured":"Lin Y, Qi Y, Jiang M, Huang W, Li B. Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB\/CD44 axis in oral squamous cell carcinoma. Int Immunopharmacol. 2023;124:110972.","journal-title":"Int Immunopharmacol"},{"key":"7875_CR12","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1038\/s41418-023-01217-x","volume":"30","author":"J Ning","year":"2023","unstructured":"Ning J, Hou X, Hao J, Zhang W, Shi Y, Huang Y, Ruan X, Zheng X, Gao M. METTL3 Inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer. Cell Death Differ. 2023;30:2265\u201379.","journal-title":"Cell Death Differ"},{"key":"7875_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.taap.2018.12.013","volume":"364","author":"X Xu","year":"2019","unstructured":"Xu X, Ye J, Huang C, Yan Y, Li J. M2 macrophage-derived IL6 mediates resistance of breast cancer cells to Hedgehog Inhibition. Toxicol Appl Pharmacol. 2019;364:77\u201382.","journal-title":"Toxicol Appl Pharmacol"},{"key":"7875_CR14","doi-asserted-by":"publisher","first-page":"14611","DOI":"10.1038\/s41598-019-51149-1","volume":"9","author":"A Haque","year":"2019","unstructured":"Haque A, Moriyama M, Kubota K, Ishiguro N, Sakamoto M, Chinju A, Mochizuki K, Sakamoto T, Kaneko N, Munemura R, et al. CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production. Sci Rep. 2019;9:14611.","journal-title":"Sci Rep"},{"key":"7875_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40164-024-00550-2","volume":"13","author":"W Chen","year":"2024","unstructured":"Chen W, Chen M, Hong L, Xiahenazi A, Huang M, Tang N, Yang X, She F, Chen Y. M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis. Exp Hematol Oncol. 2024;13:83.","journal-title":"Exp Hematol Oncol"},{"key":"7875_CR16","doi-asserted-by":"crossref","unstructured":"Zheng R, Zhang Y, Tsuji T, Gao X, Shamsi F, Wagner A, Yosef N, Cui K, Chen H, Kiebish MA, et al. MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq. Nucleic Acids Res. 2025;53.","DOI":"10.1093\/nar\/gkaf569"},{"key":"7875_CR17","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1158\/0008-5472.CAN-20-4028","volume":"81","author":"A El-Kenawi","year":"2021","unstructured":"El-Kenawi A, Dominguez-Viqueira W, Liu M, Awasthi S, Abraham-Miranda J, Keske A, Steiner KK, Noel L, Serna AN, Dhillon J, et al. Macrophage-Derived cholesterol contributes to therapeutic resistance in prostate cancer. Cancer Res. 2021;81:5477\u201390.","journal-title":"Cancer Res"},{"key":"7875_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s41586-021-04082-1","volume":"599","author":"B Zhang","year":"2021","unstructured":"Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, et al. B cell-derived GABA elicits IL-10(+) macrophages to limit anti-tumour immunity. Nature. 2021;599:471\u20136.","journal-title":"Nature"},{"key":"7875_CR19","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1126\/science.aav2588","volume":"366","author":"RD Leone","year":"2019","unstructured":"Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, et al. Glutamine Blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013\u201321.","journal-title":"Science"},{"key":"7875_CR20","doi-asserted-by":"publisher","first-page":"115064","DOI":"10.1016\/j.celrep.2024.115064","volume":"43","author":"Y Mao","year":"2024","unstructured":"Mao Y, Xia Z, Xia W, Jiang P. Metabolic reprogramming, sensing, and cancer therapy. Cell Rep. 2024;43:115064.","journal-title":"Cell Rep"},{"key":"7875_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12964-024-02018-6","volume":"23","author":"D Nan","year":"2025","unstructured":"Nan D, Yao W, Huang L, Liu R, Chen X, Xia W, Sheng H, Zhang H, Liang X, Lu Y. Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Commun Signal. 2025;23:45.","journal-title":"Cell Commun Signal"},{"key":"7875_CR22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41586-020-2857-9","volume":"587","author":"M Shang","year":"2020","unstructured":"Shang M, Cappellesso F, Amorim R, Serneels J, Virga F, Eelen G, Carobbio S, Rincon MY, Maechler P, De Bock K, et al. Macrophage-derived glutamine boosts satellite cells and muscle regeneration. Nature. 2020;587:626\u201331.","journal-title":"Nature"},{"key":"7875_CR23","doi-asserted-by":"crossref","unstructured":"Dussold C, Zilinger K, Turunen J, Heimberger AB, Miska J. Modulation of macrophage metabolism as an emerging immunotherapy strategy for cancer. J Clin Invest. 2024;134.","DOI":"10.1172\/JCI175445"},{"key":"7875_CR24","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s12272-025-01561-1","volume":"48","author":"A Vasukutty","year":"2025","unstructured":"Vasukutty A, Bhattarai PY, Choi HS. Enhancer regulation in cancer: from epigenetics to m(6)A RNA modification. Arch Pharm Res. 2025;48:706\u201335.","journal-title":"Arch Pharm Res"},{"key":"7875_CR25","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1038\/s41467-021-24813-2","volume":"12","author":"B Ye","year":"2021","unstructured":"Ye B, Fan D, Xiong W, Li M, Yuan J, Jiang Q, Zhao Y, Lin J, Liu J, Lv Y, et al. Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis. Nat Commun. 2021;12:4457.","journal-title":"Nat Commun"},{"key":"7875_CR26","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","volume":"107","author":"MP Creyghton","year":"2010","unstructured":"Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A. 2010;107:21931\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7875_CR27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.biochem.78.071107.134639","volume":"78","author":"OJ Rando","year":"2009","unstructured":"Rando OJ, Chang HY. Genome-wide views of chromatin structure. Annu Rev Biochem. 2009;78:245\u201371.","journal-title":"Annu Rev Biochem"},{"key":"7875_CR28","doi-asserted-by":"crossref","unstructured":"Lin HJ, Liu Y, Lofland D, Lin J. Breast cancer tumor microenvironment and molecular aberrations hijack tumoricidal immunity. Cancers (Basel). 2022;14.","DOI":"10.3390\/cancers14020285"},{"key":"7875_CR29","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/ncb3629","volume":"19","author":"MA Reid","year":"2017","unstructured":"Reid MA, Dai Z, Locasale JW. The impact of cellular metabolism on chromatin dynamics and epigenetics. Nat Cell Biol. 2017;19:1298\u2013306.","journal-title":"Nat Cell Biol"},{"key":"7875_CR30","doi-asserted-by":"crossref","unstructured":"Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184:3573\u2013e35873529.","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"7875_CR31","doi-asserted-by":"publisher","first-page":"100498","DOI":"10.1016\/j.crmeth.2023.100498","volume":"3","author":"S Morabito","year":"2023","unstructured":"Morabito S, Reese F, Rahimzadeh N, Miyoshi E, Swarup V. HdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell Rep Methods. 2023;3:100498.","journal-title":"Cell Rep Methods"},{"key":"7875_CR32","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/j.csbj.2024.06.035","volume":"23","author":"H Liu","year":"2024","unstructured":"Liu H, Zhang W, Zhang Y, Adegboro AA, Fasoranti DO, Dai L, Pan Z, Liu H, Xiong Y, Li W, et al. Mime: A flexible machine-learning framework to construct and visualize models for clinical characteristics prediction and feature selection. Comput Struct Biotechnol J. 2024;23:2798\u2013810.","journal-title":"Comput Struct Biotechnol J"},{"key":"7875_CR33","doi-asserted-by":"publisher","first-page":"e00461","DOI":"10.1002\/advs.202500461","volume":"12","author":"M Yuan","year":"2025","unstructured":"Yuan M, Chen S, Lin Z, Yu R, Chao K, Ye S, Li Q, Ke H, Zhang C, Huang J, et al. ACSS2-Mediated histone H4 lysine 12 crotonylation (H4K12cr) alleviates colitis via enhancing transcription of CLDN7. Adv Sci (Weinh). 2025;12:e00461.","journal-title":"Adv Sci (Weinh)"},{"key":"7875_CR34","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1038\/s41418-025-01533-4","volume":"32","author":"C Zhang","year":"2025","unstructured":"Zhang C, Yu R, Li S, Yuan M, Hu T, Liu J, Ke H, Ye S, Yun J, Huang J, et al. KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression. Cell Death Differ. 2025;32:2225\u201338.","journal-title":"Cell Death Differ"},{"key":"7875_CR35","doi-asserted-by":"publisher","first-page":"D61","DOI":"10.1093\/nar\/gkad1069","volume":"52","author":"L Taing","year":"2024","unstructured":"Taing L, Dandawate A, L\u2019Yi S, Gehlenborg N, Brown M, Meyer CA. Cistrome data browser: integrated search, analysis and visualization of chromatin data. Nucleic Acids Res. 2024;52:D61\u20136.","journal-title":"Nucleic Acids Res"},{"key":"7875_CR36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ccell.2021.11.002","volume":"40","author":"H Li","year":"2022","unstructured":"Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, et al. The allergy mediator Histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage Histamine receptor H1. Cancer Cell. 2022;40:36\u2013e5239.","journal-title":"Cancer Cell"},{"key":"7875_CR37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s10565-019-09470-y","volume":"35","author":"D Song","year":"2019","unstructured":"Song D, Yang D, Powell CA, Wang X. Cell-cell communication: old mystery and new opportunity. Cell Biol Toxicol. 2019;35:89\u201393.","journal-title":"Cell Biol Toxicol"},{"key":"7875_CR38","doi-asserted-by":"crossref","unstructured":"Krawczynska N, Wang Y, Lim K, Das Gupta A, Molino R, Lenczowski A, Abughazaleh M, Bendre SV, Fei Y, Kim H, et al. Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells. Cancer Lett. 2025:218105.","DOI":"10.1016\/j.canlet.2025.218105"},{"key":"7875_CR39","doi-asserted-by":"publisher","first-page":"1649468","DOI":"10.3389\/fimmu.2025.1649468","volume":"16","author":"W Shi","year":"2025","unstructured":"Shi W, Zhang Z, Xu X, Tian Y, Feng L, Huang X, Du Y, Li Z. Single-cell and Spatial transcriptomics integration: new frontiers in tumor microenvironment and cellular communication. Front Immunol. 2025;16:1649468.","journal-title":"Front Immunol"},{"key":"7875_CR40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12943-019-0965-7","volume":"18","author":"S Maacha","year":"2019","unstructured":"Maacha S, Bhat AA, Jimenez L, Raza A, Haris M, Uddin S, Grivel JC. Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance. Mol Cancer. 2019;18:55.","journal-title":"Mol Cancer"},{"key":"7875_CR41","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1161\/CIRCRESAHA.122.321723","volume":"132","author":"K Cui","year":"2023","unstructured":"Cui K, Gao X, Wang B, Wu H, Arulsamy K, Dong Y, Xiao Y, Jiang X, Malovichko MV, Li K, et al. Epsin nanotherapy regulates cholesterol transport to fortify atheroma regression. Circ Res. 2023;132:e22\u201342.","journal-title":"Circ Res"},{"key":"7875_CR42","doi-asserted-by":"publisher","first-page":"1562261","DOI":"10.3389\/fphar.2025.1562261","volume":"16","author":"Q Liu","year":"2025","unstructured":"Liu Q, Chen H, Tang D, Zhang H, Chen S, Meng Y, Zheng B, Liu F, Zhou J, Zhang W. Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma. Front Pharmacol. 2025;16:1562261.","journal-title":"Front Pharmacol"},{"key":"7875_CR43","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.7150\/thno.89805","volume":"14","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Fang S, Fan B, Xu K, Xu L, Wang L, Zhu L, Chen C, Wu R, Ni J, Wang J. Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer. Theranostics. 2024;14:1683\u2013700.","journal-title":"Theranostics"},{"key":"7875_CR44","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.ccell.2025.03.015","volume":"43","author":"Y Zhu","year":"2025","unstructured":"Zhu Y, Zhou Z, Du X, Lin X, Liang ZM, Chen S, Sun Y, Wang Y, Na Z, Wu Z, et al. Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion. Cancer Cell. 2025;43:1045\u2013e10601047.","journal-title":"Cancer Cell"},{"key":"7875_CR45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","volume":"136","author":"P Nicklin","year":"2009","unstructured":"Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009;136:521\u201334.","journal-title":"Cell"},{"key":"7875_CR46","doi-asserted-by":"crossref","unstructured":"Qureshi T, Bjorkmo M, Nordengen K, Gundersen V, Utheim TP, Watne LO, Storm-Mathisen J, Hassel B, Chaudhry FA. Slc38a1 conveys astroglia-derived glutamine into GABAergic interneurons for neurotransmitter GABA synthesis. Cells. 2020;9.","DOI":"10.3390\/cells9071686"},{"key":"7875_CR47","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41586-023-06299-8","volume":"620","author":"C Guo","year":"2023","unstructured":"Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620:200\u20138.","journal-title":"Nature"},{"key":"7875_CR48","doi-asserted-by":"publisher","first-page":"C550","DOI":"10.1152\/ajpcell.00169.2023","volume":"325","author":"G Taurino","year":"2023","unstructured":"Taurino G, Chiu M, Bianchi MG, Griffini E, Bussolati O. The SLC38A5\/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment. Am J Physiol Cell Physiol. 2023;325:C550\u201362.","journal-title":"Am J Physiol Cell Physiol"},{"key":"7875_CR49","doi-asserted-by":"crossref","unstructured":"Li X, Moller SH, Park J, Chuang YM, Hsueh PC, Chang TH, Kao KC, Gallart-Ayala H, Wang YH, Peng JJ, et al. Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages. J Exp Med. 2025;222.","DOI":"10.1084\/jem.20241426"},{"key":"7875_CR50","doi-asserted-by":"crossref","unstructured":"Cosin-Roger J, Ortiz-Masia D, Barrachina MD, Calatayud S. Metabolite sensing gpcrs: promising therapeutic targets for cancer treatment? Cells. 2020;9.","DOI":"10.3390\/cells9112345"},{"key":"7875_CR51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2022.12.007","volume":"186","author":"C Correia-Melo","year":"2023","unstructured":"Correia-Melo C, Kamrad S, Tengolics R, Messner CB, Trebulle P, Townsend S, Jayasree Varma S, Freiwald A, Heineike BM, Campbell K, et al. Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan. Cell. 2023;186:63\u2013e7921.","journal-title":"Cell"},{"key":"7875_CR52","doi-asserted-by":"publisher","first-page":"104802","DOI":"10.1016\/j.jbc.2023.104802","volume":"299","author":"Y Xu","year":"2023","unstructured":"Xu Y, Kusuyama J, Osana S, Matsuhashi S, Li L, Takada H, Inada H, Nagatomi R. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. J Biol Chem. 2023;299:104802.","journal-title":"J Biol Chem"},{"key":"7875_CR53","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2022.02.015","volume":"34","author":"SM Hochrein","year":"2022","unstructured":"Hochrein SM, Wu H, Eckstein M, Arrigoni L, Herman JS, Schumacher F, Gerecke C, Rosenfeldt M, Grun D, Kleuser B, et al. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab. 2022;34:516\u2013e532511.","journal-title":"Cell Metab"},{"key":"7875_CR54","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.1038\/s41388-019-0845-z","volume":"38","author":"S Mishra","year":"2019","unstructured":"Mishra S, Bernal C, Silvano M, Anand S, Ruiz i Altaba A. The protein secretion modulator TMED9 drives CNIH4\/TGFalpha\/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Oncogene. 2019;38:5817\u201337.","journal-title":"Oncogene"},{"key":"7875_CR55","doi-asserted-by":"publisher","first-page":"146961","DOI":"10.1016\/j.gene.2022.146961","volume":"850","author":"H Zhang","year":"2023","unstructured":"Zhang H, Lin Y, Zhuang M, Zhu L, Dai Y, Lin M. Screening and identification of CNIH4 gene associated with cell proliferation in gastric cancer based on a large-scale CRISPR-Cas9 screening database DepMap. Gene. 2023;850:146961.","journal-title":"Gene"},{"key":"7875_CR56","doi-asserted-by":"publisher","first-page":"12943","DOI":"10.1002\/cam4.5947","volume":"12","author":"Z Fang","year":"2023","unstructured":"Fang Z, Kong F, Zeng J, Zhang Z, Wang Y, Wang Y, Duan J, Chen L, Wang J, Liu F. Integrated analysis based on vesicle trafficking-related genes identifying CNIH4 as a novel therapeutic target for glioma. Cancer Med. 2023;12:12943\u201359.","journal-title":"Cancer Med"},{"key":"7875_CR57","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3233\/CBM-220143","volume":"35","author":"H Liu","year":"2022","unstructured":"Liu H, Li Y. Potential roles of Cornichon family AMPA receptor auxiliary protein 4 (CNIH4) in head and neck squamous cell carcinoma. Cancer Biomark. 2022;35:439\u201350.","journal-title":"Cancer Biomark"},{"key":"7875_CR58","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1038\/s41467-020-17181-w","volume":"11","author":"MB Ishak Gabra","year":"2020","unstructured":"Ishak Gabra MB, Yang Y, Li H, Senapati P, Hanse EA, Lowman XH, Tran TQ, Zhang L, Doan LT, Xu X, et al. Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth. Nat Commun. 2020;11:3326.","journal-title":"Nat Commun"},{"key":"7875_CR59","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ni.3796","volume":"18","author":"PS Liu","year":"2017","unstructured":"Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, et al. alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985\u201394.","journal-title":"Nat Immunol"},{"key":"7875_CR60","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1111\/cas.14884","volume":"112","author":"A Okabe","year":"2021","unstructured":"Okabe A, Kaneda A. Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer. Cancer Sci. 2021;112:2081\u20138.","journal-title":"Cancer Sci"},{"key":"7875_CR61","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pharmthera.2019.02.014","volume":"199","author":"P Thandapani","year":"2019","unstructured":"Thandapani P. Super-enhancers in cancer. Pharmacol Ther. 2019;199:129\u201338.","journal-title":"Pharmacol Ther"},{"key":"7875_CR62","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/21541264.2020.1713682","volume":"11","author":"J Yao","year":"2020","unstructured":"Yao J, Chen J, Li LY, Wu M. Epigenetic plasticity of enhancers in cancer. Transcription. 2020;11:26\u201336.","journal-title":"Transcription"},{"key":"7875_CR63","doi-asserted-by":"publisher","first-page":"106418","DOI":"10.1016\/j.phrs.2022.106418","volume":"184","author":"M Hashemi","year":"2022","unstructured":"Hashemi M, Moosavi MS, Abed HM, Dehghani M, Aalipour M, Heydari EA, Behroozaghdam M, Entezari M, Salimimoghadam S, Gunduz ES, et al. Long non-coding RNA (lncRNA) H19 in human cancer: from proliferation and metastasis to therapy. Pharmacol Res. 2022;184:106418.","journal-title":"Pharmacol Res"},{"key":"7875_CR64","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/s41419-021-04421-0","volume":"12","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Zhao H, Chen Y, Li K, Li T, Chen J, Zhang B, Guo C, Qing L, Shen J, et al. Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p\/FOXM1 axis. Cell Death Dis. 2021;12:1129.","journal-title":"Cell Death Dis"},{"key":"7875_CR65","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1080\/15548627.2022.2062875","volume":"18","author":"C Bodineau","year":"2022","unstructured":"Bodineau C, Tome M, Murdoch PDS, Duran RV. Glutamine, MTOR and autophagy: a multiconnection relationship. Autophagy. 2022;18:2749\u201350.","journal-title":"Autophagy"},{"key":"7875_CR66","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1038\/s41467-022-30130-z","volume":"13","author":"HM La","year":"2022","unstructured":"La HM, Liao J, Legrand JMD, Rossello FJ, Chan AL, Vaghjiani V, Cain JE, Papa A, Lee TL, Hobbs RM. Distinctive molecular features of regenerative stem cells in the damaged male germline. Nat Commun. 2022;13:2500.","journal-title":"Nat Commun"},{"key":"7875_CR67","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.mam.2016.09.001","volume":"54","author":"X Gao","year":"2017","unstructured":"Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017;54:50\u20137.","journal-title":"Mol Aspects Med"},{"key":"7875_CR68","doi-asserted-by":"publisher","first-page":"115836","DOI":"10.1016\/j.bone.2020.115836","volume":"145","author":"S Lee","year":"2021","unstructured":"Lee S, Kim HS, Kim MJ, Min KY, Choi WS, You JS. Glutamine metabolite alpha-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation. Bone. 2021;145:115836.","journal-title":"Bone"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-07875-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07875-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07875-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:08:18Z","timestamp":1774530498000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-07875-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7875"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-07875-y","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"30 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"423"}}