{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:44:35Z","timestamp":1793727875071,"version":"4.6.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Youth Science and Technology Project of Lianyungang Health Commission","award":["QN202513"],"award-info":[{"award-number":["QN202513"]}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["XZSYSKF2025015"],"award-info":[{"award-number":["XZSYSKF2025015"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009159","name":"Lianyungang Science and Technology Bureau","doi-asserted-by":"publisher","award":["25LCJCYJ018"],"award-info":[{"award-number":["25LCJCYJ018"]}],"id":[{"id":"10.13039\/501100009159","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["M82510"],"award-info":[{"award-number":["M82510"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-07880-1","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:06:36Z","timestamp":1771923996000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanism of ASIC4 in regulating MHC-I-mediated immune evasion in pancreatic cancer"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3787-6275","authenticated-orcid":false,"given":"Qi","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwu","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-8364","authenticated-orcid":false,"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"1","key":"7880_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13073-019-0642-x","volume":"11","author":"G Ehx","year":"2019","unstructured":"Ehx G, Perreault C. Discovery and characterization of actionable tumor antigens[J]. Genome Med. 2019;11(1):29.","journal-title":"Genome Med"},{"issue":"9","key":"7880_CR2","doi-asserted-by":"publisher","first-page":"e1476816","DOI":"10.1080\/2162402X.2018.1476816","volume":"7","author":"M Poch","year":"2018","unstructured":"Poch M, Hall M, Joerger A, et al. Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer[J]. Oncoimmunology. 2018;7(9):e1476816.","journal-title":"Oncoimmunology"},{"issue":"1","key":"7880_CR3","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1038\/s41467-018-05570-1","volume":"9","author":"A Chakravarthy","year":"2018","unstructured":"Chakravarthy A, Furness A, Joshi K, et al. Pan-cancer Deconvolution of tumour composition using DNA methylation[J]. Nat Commun. 2018;9(1):3220.","journal-title":"Nat Commun"},{"issue":"13","key":"7880_CR4","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1158\/1078-0432.CCR-17-2961","volume":"24","author":"HA Yu","year":"2018","unstructured":"Yu HA, Suzawa K, Jordan E, et al. Concurrent alterations in EGFR-Mutant lung cancers associated with resistance to EGFR kinase inhibitors and characterization of MTOR as a mediator of resistance[J]. Clin Cancer Res. 2018;24(13):3108\u201318.","journal-title":"Clin Cancer Res"},{"issue":"8","key":"7880_CR5","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","volume":"15","author":"EJ Wherry","year":"2015","unstructured":"Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion[J]. Nat Rev Immunol. 2015;15(8):486\u201399.","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"7880_CR6","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","volume":"56","author":"I Mellman","year":"2023","unstructured":"Mellman I, Chen DS, Powles T, et al. The cancer-immunity cycle: Indication, genotype, and immunotype[J]. Immunity. 2023;56(10):2188\u2013205.","journal-title":"Immunity"},{"key":"7880_CR7","doi-asserted-by":"publisher","first-page":"6012810","DOI":"10.1155\/2017\/6012810","volume":"2017","author":"J Zhao","year":"2017","unstructured":"Zhao J, Li J, Schlosser HA, et al. Targeting cancer stem cells and their niche: current therapeutic implications and challenges in pancreatic cancer[J]. Stem Cells Int. 2017;2017:6012810.","journal-title":"Stem Cells Int"},{"key":"7880_CR8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12974-015-0465-7","volume":"12","author":"YC Wang","year":"2015","unstructured":"Wang YC, Li WZ, Wu Y, et al. Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons[J]. J Neuroinflammation. 2015;12:246.","journal-title":"J Neuroinflammation"},{"issue":"18","key":"7880_CR9","doi-asserted-by":"publisher","first-page":"18783","DOI":"10.1074\/jbc.M401477200","volume":"279","author":"M Paukert","year":"2004","unstructured":"Paukert M, Sidi S, Russell C, et al. A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication[J]. J Biol Chem. 2004;279(18):18783\u201391.","journal-title":"J Biol Chem"},{"issue":"6621","key":"7880_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/386173a0","volume":"386","author":"R Waldmann","year":"1997","unstructured":"Waldmann R, Champigny G, Bassilana F, et al. A proton-gated cation channel involved in acid-sensing[J]. Nature. 1997;386(6621):173\u20137.","journal-title":"Nature"},{"issue":"4","key":"7880_CR11","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1073\/pnas.94.4.1459","volume":"94","author":"J Garcia-Anoveros","year":"1997","unstructured":"Garcia-Anoveros J, Derfler B, Neville-Golden J, et al. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels[J]. Proc Natl Acad Sci U S A. 1997;94(4):1459\u201364.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"7880_CR12","doi-asserted-by":"publisher","first-page":"7879","DOI":"10.1074\/jbc.271.14.7879","volume":"271","author":"MP Price","year":"1996","unstructured":"Price MP, Snyder PM, Welsh MJ. Cloning and expression of a novel human brain Na+ channel[J]. J Biol Chem. 1996;271(14):7879\u201382.","journal-title":"J Biol Chem"},{"key":"7880_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuropharm.2014.12.011","volume":"94","author":"SH Lin","year":"2015","unstructured":"Lin SH, Sun WH, Chen CC. Genetic exploration of the role of acid-sensing ion channels[J]. Neuropharmacology. 2015;94:99\u2013118.","journal-title":"Neuropharmacology"},{"issue":"3","key":"7880_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0959-4388(98)80070-6","volume":"8","author":"R Waldmann","year":"1998","unstructured":"Waldmann R, Lazdunski M. H(+)-gated cation channels: neuronal acid sensors in the NaC\/DEG family of ion channels[J]. Curr Opin Neurobiol. 1998;8(3):418\u201324.","journal-title":"Curr Opin Neurobiol"},{"issue":"4","key":"7880_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1161\/CIRCRESAHA.117.310450","volume":"120","author":"T Saito","year":"2017","unstructured":"Saito T, Sadoshima J. Unexpected functional consequences of the loss of the Autophagy-Related conjugation System[J]. Circ Res. 2017;120(4):610\u20132.","journal-title":"Circ Res"},{"key":"7880_CR16","doi-asserted-by":"publisher","first-page":"576547","DOI":"10.3389\/fphar.2020.576547","volume":"11","author":"C Bai","year":"2020","unstructured":"Bai C, Zhang Z, Zhou L, et al. Repurposing Ziyuglycoside II against colorectal cancer via orchestrating apoptosis and Autophagy[J]. Front Pharmacol. 2020;11:576547.","journal-title":"Front Pharmacol"},{"issue":"7806","key":"7880_CR17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","volume":"581","author":"K Yamamoto","year":"2020","unstructured":"Yamamoto K, Venida A, Yano J, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I[J]. Nature. 2020;581(7806):100\u20135.","journal-title":"Nature"},{"key":"7880_CR18","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3389\/fimmu.2020.00746","volume":"11","author":"N Geng","year":"2020","unstructured":"Geng N, Wang X, Yu X, et al. Staphylococcus aureus avoids autophagy clearance of bovine mammary epithelial cells by impairing lysosomal Function[J]. Front Immunol. 2020;11:746.","journal-title":"Front Immunol"},{"issue":"4","key":"7880_CR19","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41418-019-0297-6","volume":"26","author":"N Germic","year":"2019","unstructured":"Germic N, Frangez Z, Yousefi S, et al. Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation[J]. Cell Death Differ. 2019;26(4):715\u201327.","journal-title":"Cell Death Differ"},{"issue":"1","key":"7880_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","volume":"17","author":"E Becht","year":"2016","unstructured":"Becht E, Giraldo NA, Lacroix L, et al. Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression[J]. Genome Biol. 2016;17(1):218.","journal-title":"Genome Biol"},{"issue":"14","key":"7880_CR21","doi-asserted-by":"publisher","first-page":"i436","DOI":"10.1093\/bioinformatics\/btz363","volume":"35","author":"G Sturm","year":"2019","unstructured":"Sturm G, Finotello F, Petitprez F, et al. Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology[J]. Bioinformatics. 2019;35(14):i436\u201345.","journal-title":"Bioinformatics"},{"issue":"9","key":"7880_CR22","doi-asserted-by":"publisher","first-page":"e1621677","DOI":"10.1080\/2162402X.2019.1621677","volume":"8","author":"C Zhu","year":"2019","unstructured":"Zhu C, Zou C, Guan G, et al. Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma[J]. Oncoimmunology. 2019;8(9):e1621677.","journal-title":"Oncoimmunology"},{"issue":"1","key":"7880_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1053\/j.gastro.2017.03.008","volume":"153","author":"SH Jiang","year":"2017","unstructured":"Jiang SH, Li J, Dong FY, et al. Increased serotonin signaling contributes to the Warburg effect in pancreatic tumor cells under metabolic stress and promotes growth of pancreatic tumors in Mice[J]. Gastroenterology. 2017;153(1):277\u201391.","journal-title":"Gastroenterology"},{"issue":"1","key":"7880_CR24","doi-asserted-by":"publisher","first-page":"4622","DOI":"10.1038\/s41467-019-12525-7","volume":"10","author":"R Nicolle","year":"2019","unstructured":"Nicolle R, Ayadi M, Gomez-Brouchet A, et al. Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression[J]. Nat Commun. 2019;10(1):4622.","journal-title":"Nat Commun"},{"issue":"1","key":"7880_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13073-019-0638-6","volume":"11","author":"F Finotello","year":"2019","unstructured":"Finotello F, Mayer C, Plattner C, et al. Molecular and Pharmacological modulators of the tumor immune contexture revealed by Deconvolution of RNA-seq data[J]. Genome Med. 2019;11(1):34.","journal-title":"Genome Med"},{"issue":"1","key":"7880_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape[J]. Genome Biol. 2017;18(1):220.","journal-title":"Genome Biol"},{"issue":"4","key":"7880_CR27","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/eji.200535326","volume":"36","author":"D Rajagopal","year":"2006","unstructured":"Rajagopal D, Bal V, Mayor S, et al. A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules[J]. Eur J Immunol. 2006;36(4):828\u201341.","journal-title":"Eur J Immunol"},{"issue":"3","key":"7880_CR28","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00251-018-1082-2","volume":"71","author":"A Kelly","year":"2019","unstructured":"Kelly A, Trowsdale J. Genetics of antigen processing and presentation[J]. Immunogenetics. 2019;71(3):161\u201370.","journal-title":"Immunogenetics"},{"issue":"1","key":"7880_CR29","first-page":"60","volume":"1","author":"C Watts","year":"1999","unstructured":"Watts C, Powis S. Pathways of antigen processing and presentation[J]. Rev Immunogenet. 1999;1(1):60\u201374.","journal-title":"Rev Immunogenet"},{"issue":"6052","key":"7880_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1209202","volume":"334","author":"L Abi-Rached","year":"2011","unstructured":"Abi-Rached L, Jobin MJ, Kulkarni S, et al. The shaping of modern human immune systems by multiregional admixture with archaic humans[J]. Science. 2011;334(6052):89\u201394.","journal-title":"Science"},{"issue":"3","key":"7880_CR31","first-page":"731","volume":"45","author":"G Jiang","year":"2020","unstructured":"Jiang G, Xin R, Yuan W, et al. Ligustrazine ameliorates acute kidney injury through downregulation of NOD2\u2013mediated inflammation[J]. Int J Mol Med. 2020;45(3):731\u201342.","journal-title":"Int J Mol Med"},{"issue":"5","key":"7880_CR32","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s13402-023-00829-2","volume":"46","author":"L Zhu","year":"2023","unstructured":"Zhu L, Li B, Li R, et al. METTL3 suppresses pancreatic ductal adenocarcinoma progression through activating endogenous dsRNA-induced anti-tumor immunity[J]. Cell Oncol (Dordr). 2023;46(5):1529\u201341.","journal-title":"Cell Oncol (Dordr)"},{"key":"7880_CR33","doi-asserted-by":"crossref","unstructured":"Ho T, Nasti A, Seki A, et al. Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis[J]. J Immunother Cancer. 2020;8(2).","DOI":"10.1136\/jitc-2020-001367"},{"issue":"15","key":"7880_CR34","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1093\/cvr\/cvab334","volume":"118","author":"H Yang","year":"2022","unstructured":"Yang H, Tenorio LL, Barioni NO, et al. The molecular makeup of peripheral and central baroreceptors: stretching a role for transient receptor potential (TRP), epithelial sodium channel (ENaC), acid sensing ion channel (ASIC), and piezo channels[J]. Cardiovasc Res. 2022;118(15):3052\u201370.","journal-title":"Cardiovasc Res"},{"key":"7880_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuropharm.2014.12.016","volume":"94","author":"S Grunder","year":"2015","unstructured":"Grunder S, Pusch M. Biophysical properties of acid-sensing ion channels (ASICs)[J]. Neuropharmacology. 2015;94:9\u201318.","journal-title":"Neuropharmacology"},{"issue":"22","key":"7880_CR36","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1038\/emboj.2008.213","volume":"27","author":"E Deval","year":"2008","unstructured":"Deval E, Noel J, Lay N, et al. ASIC3, a sensor of acidic and primary inflammatory pain[J]. EMBO J. 2008;27(22):3047\u201355.","journal-title":"EMBO J"},{"issue":"6","key":"7880_CR37","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","volume":"118","author":"ZG Xiong","year":"2004","unstructured":"Xiong ZG, Zhu XM, Chu XP, et al. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels[J]. Cell. 2004;118(6):687\u201398.","journal-title":"Cell"},{"issue":"Pt 1","key":"7880_CR38","first-page":"151","volume":"130","author":"G Pignataro","year":"2007","unstructured":"Pignataro G, Simon RP, Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia[J]. Brain. 2007;130(Pt 1):151\u20138.","journal-title":"Brain"},{"issue":"7","key":"7880_CR39","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/nn.2132","volume":"11","author":"AE Ziemann","year":"2008","unstructured":"Ziemann AE, Schnizler MK, Albert GW, et al. Seizure termination by acidosis depends on ASIC1a[J]. Nat Neurosci. 2008;11(7):816\u201322.","journal-title":"Nat Neurosci"},{"issue":"3","key":"7880_CR40","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s12035-011-8204-2","volume":"44","author":"YZ Wang","year":"2011","unstructured":"Wang YZ, Xu TL. Acidosis, acid-sensing ion channels, and neuronal cell death[J]. Mol Neurobiol. 2011;44(3):350\u20138.","journal-title":"Mol Neurobiol"},{"issue":"1\u20132","key":"7880_CR41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11010-010-0412-y","volume":"340","author":"FL Yuan","year":"2010","unstructured":"Yuan FL, Chen FH, Lu WG, et al. Acid-sensing ion channel 1a mediates acid-induced increases in intracellular calcium in rat articular chondrocytes[J]. Mol Cell Biochem. 2010;340(1\u20132):153\u20139.","journal-title":"Mol Cell Biochem"},{"key":"7880_CR42","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.2147\/OTT.S157129","volume":"11","author":"J Wu","year":"2018","unstructured":"Wu J, Wang J, Su Q, et al. Traditional Chinese medicine astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis[J]. Onco Targets Ther. 2018;11:2685\u201398.","journal-title":"Onco Targets Ther"},{"key":"7880_CR43","doi-asserted-by":"publisher","first-page":"3186328","DOI":"10.1155\/2017\/3186328","volume":"2017","author":"WL Fan","year":"2017","unstructured":"Fan WL, Shiao MS, Hui RC, et al. HLA association with Drug-Induced adverse Reactions[J]. J Immunol Res. 2017;2017:3186328.","journal-title":"J Immunol Res"},{"key":"7880_CR44","doi-asserted-by":"publisher","first-page":"10582","DOI":"10.1038\/ncomms10582","volume":"7","author":"DB Johnson","year":"2016","unstructured":"Johnson DB, Estrada MV, Salgado R, et al. Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1\/PD-L1 therapy[J]. Nat Commun. 2016;7:10582.","journal-title":"Nat Commun"},{"issue":"1","key":"7880_CR45","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1038\/s41467-017-01460-0","volume":"8","author":"M Lauss","year":"2017","unstructured":"Lauss M, Donia M, Harbst K, et al. Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma[J]. Nat Commun. 2017;8(1):1738.","journal-title":"Nat Commun"},{"key":"7880_CR46","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1038\/s41467-017-01460-0","volume":"8","author":"M Lauss","year":"2017","unstructured":"Lauss M, Donia M, Harbst K, Andersen R, Mitra S, Rosengren F, et al. Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma. Nat Commun. 2017;8:1738.","journal-title":"Nat Commun"},{"issue":"9","key":"7880_CR47","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1158\/1078-0432.CCR-15-2294","volume":"22","author":"LD Rothermel","year":"2016","unstructured":"Rothermel LD, Sabesan AC, Stephens DJ, et al. Identification of an Immunogenic subset of metastatic uveal Melanoma[J]. Clin Cancer Res. 2016;22(9):2237\u201349.","journal-title":"Clin Cancer Res"},{"issue":"18","key":"7880_CR48","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1016\/j.cell.2023.07.016","volume":"186","author":"X Chen","year":"2023","unstructured":"Chen X, Lu Q, Zhou H, et al. A membrane-associated MHC-I inhibitory axis for cancer immune evasion[J]. Cell. 2023;186(18):3903\u201320.","journal-title":"Cell"},{"issue":"1","key":"7880_CR49","doi-asserted-by":"publisher","first-page":"7041","DOI":"10.1038\/s41467-021-27349-7","volume":"12","author":"Y Deng","year":"2021","unstructured":"Deng Y, Xia X, Zhao Y, et al. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance[J]. Nat Commun. 2021;12(1):7041.","journal-title":"Nat Commun"},{"issue":"1","key":"7880_CR50","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/s41467-018-03225-9","volume":"9","author":"D Chen","year":"2018","unstructured":"Chen D, Xie J, Fiskesund R, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype[J]. Nat Commun. 2018;9(1):873.","journal-title":"Nat Commun"},{"issue":"13","key":"7880_CR51","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1158\/1078-0432.CCR-19-4042","volume":"26","author":"HJ Zeh","year":"2020","unstructured":"Zeh HJ, Bahary N, Boone BA, et al. A randomized phase II preoperative study of autophagy Inhibition with High-Dose hydroxychloroquine and Gemcitabine\/Nab-Paclitaxel in pancreatic cancer Patients[J]. Clin Cancer Res. 2020;26(13):3126\u201334.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"7880_CR52","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1001\/jamaoncol.2019.0684","volume":"5","author":"TB Karasic","year":"2019","unstructured":"Karasic TB, O\u2019Hara MH, Loaiza-Bonilla A, et al. Effect of gemcitabine and nab-Paclitaxel with or without hydroxychloroquine on patients with advanced pancreatic cancer: A phase 2 randomized clinical Trial[J]. JAMA Oncol. 2019;5(7):993\u20138.","journal-title":"JAMA Oncol"},{"issue":"3","key":"7880_CR53","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/s41418-019-0444-0","volume":"27","author":"CA Hubner","year":"2020","unstructured":"Hubner CA, Dikic I. ER-phagy and human diseases[J]. Cell Death Differ. 2020;27(3):833\u201342.","journal-title":"Cell Death Differ"},{"issue":"3","key":"7880_CR54","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.devcel.2018.09.015","volume":"47","author":"PD Velentzas","year":"2018","unstructured":"Velentzas PD, Zhang L, Das G, et al. The Proton-Coupled monocarboxylate transporter Hermes is necessary for autophagy during cell Death[J]. Dev Cell. 2018;47(3):281\u201393.","journal-title":"Dev Cell"},{"issue":"13","key":"7880_CR55","first-page":"7520","volume":"48","author":"SL Schwartz","year":"2020","unstructured":"Schwartz SL, Park EN, Vachon VK, et al. Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs[J]. Nucleic Acids Res. 2020;48(13):7520\u201331.","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-07880-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07880-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07880-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:03:33Z","timestamp":1772467413000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-07880-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7880"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-07880-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7975326\/v1","asserted-by":"object"}]},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no competing interest exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"304"}}