{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:28Z","timestamp":1791234748614,"version":"4.1.0"},"reference-count":212,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-07887-8","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:33:50Z","timestamp":1772271230000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting metabolic reprogramming to enhance adoptive immunotherapy: emerging mechanisms and translational perspectives"],"prefix":"10.1186","volume":"24","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"7887_CR1","doi-asserted-by":"crossref","unstructured":"Haddad FG, Kantarjian H, Short NJ, Jain N, Senapati J, Ravandi F, et al. Incorporation of immunotherapy into adult B-Cell acute lymphoblastic leukemia therapy. J Natl Compr Cancer Network. 2025;23(8).","DOI":"10.6004\/jnccn.2025.7050"},{"key":"7887_CR2","doi-asserted-by":"crossref","unstructured":"Roddie C, Dias J, O\u2019Reilly M, Abbasian M, Cadinanos-Garai A, Vispute K, et al. Matched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletion. Blood. 2025.","DOI":"10.1182\/blood.2025028790"},{"issue":"1","key":"7887_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13045-023-01492-8","volume":"16","author":"P Zhang","year":"2023","unstructured":"Zhang P, Zhang G, Wan X. Challenges and new technologies in adoptive cell therapy. J Hematol Oncol. 2023;16(1):97.","journal-title":"J Hematol Oncol"},{"issue":"7","key":"7887_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12032-025-02808-z","volume":"42","author":"A Dogra","year":"2025","unstructured":"Dogra A, Yadav RK, Singh H, Datt V. Emerging frontiers in adoptive cell therapies: innovations, challenges, and future perspectives. Med Oncol. 2025;42(7):261.","journal-title":"Med Oncol (Northwood, Lond, Engl)"},{"issue":"1","key":"7887_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41420-025-02403-1","volume":"11","author":"Y Shi","year":"2025","unstructured":"Shi Y, Zhang H, Miao C. Metabolic reprogram and T cell differentiation in inflammation: current evidence and future perspectives. Cell Death Discov. 2025;11(1):123.","journal-title":"Cell Death Discov"},{"key":"7887_CR6","doi-asserted-by":"crossref","unstructured":"Berahovich R, Liu X, Zhou H, Tsadik E, Xu S, Golubovskaya V, et al. Hypoxia selectively impairs CAR-T cells in vitro. Cancers. 2019;11(5).","DOI":"10.3390\/cancers11050602"},{"issue":"11","key":"7887_CR7","doi-asserted-by":"publisher","first-page":"108500","DOI":"10.1016\/j.celrep.2020.108500","volume":"33","author":"WJ Quinn 3rd","year":"2020","unstructured":"Quinn WJ 3rd, Jiao J, TeSlaa T, Stadanlick J, Wang Z, Wang L, et al. Lactate limits T cell proliferation via the NAD(H) redox state. Cell Rep. 2020;33(11):108500.","journal-title":"Cell Rep"},{"issue":"12","key":"7887_CR8","first-page":"785","volume":"21","author":"K DePeaux","year":"2021","unstructured":"DePeaux K, Delgoffe GM. Metabolic barriers to cancer immunotherapy, Nature reviews. Immunology. 2021;21(12):785\u201397.","journal-title":"Immunology"},{"issue":"4","key":"7887_CR9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41571-025-00992-5","volume":"22","author":"TJ Bock","year":"2025","unstructured":"Bock TJ, Colonne CK, Fiorenza S, Turtle CJ. Outcome correlates of approved CD19-targeted CAR T cells for large B cell lymphoma. Nat Rev Clin Oncol. 2025;22(4):241\u201361.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"7887_CR10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13045-024-01568-z","volume":"17","author":"R Zheng","year":"2024","unstructured":"Zheng R, Zhu X, Xiao Y. Advances in CAR-T-cell therapy in T-cell malignancies. J Hematol Oncol. 2024;17(1):49.","journal-title":"J Hematol Oncol"},{"key":"7887_CR11","doi-asserted-by":"crossref","unstructured":"O\u2019Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, et al. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med. 2017;9(399).","DOI":"10.1126\/scitranslmed.aaa0984"},{"issue":"11","key":"7887_CR12","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1158\/0008-5472.CAN-20-2701","volume":"81","author":"E Schoutrop","year":"2021","unstructured":"Schoutrop E, El-Serafi I, Poiret T, Zhao Y, Gultekin O, He R, et al. Mesothelin-specific CAR T cells target ovarian cancer. Cancer Res. 2021;81(11):3022\u201335.","journal-title":"Cancer Res"},{"issue":"8047","key":"7887_CR13","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/s41586-024-08261-8","volume":"637","author":"D Steffin","year":"2025","unstructured":"Steffin D, Ghatwai N, Montalbano A, Rathi P, Courtney AN, Arnett AB, et al. Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers. Nature. 2025;637(8047):940\u201346.","journal-title":"Nature"},{"key":"7887_CR14","doi-asserted-by":"crossref","unstructured":"Yamashita N, Long M, Fushimi A, Yamamoto M, Hata T, Hagiwara M, et al. MUC1-C integrates activation of the IFN-\u03b3 pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer. J Immunother Cancer. 2021;9(1).","DOI":"10.1136\/jitc-2020-002115"},{"key":"7887_CR15","doi-asserted-by":"publisher","first-page":"1560280","DOI":"10.3389\/fimmu.2025.1560280","volume":"16","author":"Q Shao","year":"2025","unstructured":"Shao Q, Deng J, Wu H, Huang Z. HER2-positive gastric cancer: from targeted therapy to CAR-T cell therapy. Front Immunol. 2025;16:1560280.","journal-title":"Front Immunol"},{"issue":"4","key":"7887_CR16","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41591-022-01726-1","volume":"28","author":"V Narayan","year":"2022","unstructured":"Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, Davis MM, et al. PSMA-targeting TGF\u03b2-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. Nat Med. 2022;28(4):724\u201334.","journal-title":"Nat Med"},{"issue":"1","key":"7887_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ccell.2023.11.011","volume":"42","author":"S Kaczanowska","year":"2024","unstructured":"Kaczanowska S, Murty T, Alimadadi A, Contreras CF, Duault C, Subrahmanyam PB, et al. Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy. Cancer Cell. 2024;42(1):35\u201351.e8.","journal-title":"Cancer Cell"},{"issue":"8","key":"7887_CR18","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1038\/s41591-024-03037-z","volume":"30","author":"C Qi","year":"2024","unstructured":"Qi C, Liu C, Gong J, Liu D, Wang X, Zhang P, et al. Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results. Nat Med. 2024;30(8):2224\u201334.","journal-title":"Nat Med"},{"key":"7887_CR19","doi-asserted-by":"crossref","unstructured":"Saberian C, Amaria RN, Najjar AM, Radvanyi LG, Haymaker CL, Forget MA, et al. Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma. J Immunother Cancer. 2021;9(5).","DOI":"10.1136\/jitc-2021-002449"},{"issue":"3","key":"7887_CR20","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1084\/jem.179.3.1005","volume":"179","author":"AB Bakker","year":"1994","unstructured":"Bakker AB, Schreurs MW, de Boer AJ, Kawakami Y, Rosenberg SA, Adema GJ, et al. Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J Exp Med. 1994;179(3):1005\u201309.","journal-title":"J Exp Med"},{"issue":"7","key":"7887_CR21","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1158\/2326-6066.CIR-18-0498","volume":"7","author":"E Reeves","year":"2019","unstructured":"Reeves E, Wood O, Ottensmeier CH, King EV, Thomas GJ, Elliott T, et al. HPV Epitope processing differences correlate with ERAP1 allotype and extent of CD8(+) T-cell tumor infiltration in OPSCC. Cancer Immunol Res. 2019;7(7):1202\u201313.","journal-title":"Cancer Immunol Res"},{"key":"7887_CR22","doi-asserted-by":"crossref","unstructured":"Albertsmeier M, Altendorf-Hofmann A, Lindner LH, Issels RD, Kampmann E, D\u00fcrr HR, et al. Cancer testis antigens and immunotherapy: expression of PRAME is associated with prognosis in soft tissue sarcoma. Cancers. 2020;12(12).","DOI":"10.3390\/cancers12123612"},{"key":"7887_CR23","doi-asserted-by":"crossref","unstructured":"\u010ceprnja T, Tomi\u0107 S, Peri\u0107 Balja M, Maru\u0161i\u0107 Z, Bla\u017ei\u0107evi\u0107 V, Spagnoli GC, et al. Prognostic value of \u201cbasal-like\u201d morphology, tumor-infiltrating lymphocytes and multi-MAGE-A expression in triple-negative breast cancer. Int J Mol Sci. 2024;25(8).","DOI":"10.3390\/ijms25084513"},{"issue":"23","key":"7887_CR24","doi-asserted-by":"publisher","first-page":"12826","DOI":"10.1073\/pnas.1921964117","volume":"117","author":"MJW Sim","year":"2020","unstructured":"Sim MJW, Lu J, Spencer M, Hopkins F, Tran E, Rosenberg SA, et al. High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D. Proc Natl Acad Sci USA. 2020;117(23):12826\u201335.","journal-title":"Proc Natl Acad Sci USA"},{"key":"7887_CR25","doi-asserted-by":"publisher","first-page":"104945","DOI":"10.1016\/j.oraloncology.2020.104945","volume":"111","author":"TC Chen","year":"2020","unstructured":"Chen TC, Wu CT, Wang CP, Lou PJ, Ko JY, Chang YL. The differences of immunologic and TP53 mutant phenotypes between synchronous and metachronous head and neck cancer and esophageal cancer. Oral Oncol. 2020;111:104945.","journal-title":"Oral Oncol"},{"key":"7887_CR26","doi-asserted-by":"publisher","first-page":"1493346","DOI":"10.3389\/fphar.2025.1493346","volume":"16","author":"W He","year":"2025","unstructured":"He W, Cui K, Farooq MA, Huang N, Zhu S, Jiang D, et al. TCR-T cell therapy for solid tumors: challenges and emerging solutions. Front Pharmacol. 2025;16:1493346.","journal-title":"Front Pharmacol"},{"issue":"1","key":"7887_CR27","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.1038\/s41467-022-32491-x","volume":"13","author":"A Gyurdieva","year":"2022","unstructured":"Gyurdieva A, Zajic S, Chang YF, Houseman EA, Zhong S, Kim J, et al. Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma. Nat Commun. 2022;13(1):5296.","journal-title":"Nat Commun"},{"key":"7887_CR28","doi-asserted-by":"crossref","unstructured":"Liu M, Akahori Y, Imai N, Wang L, Negishi K, Kato T, et al. MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity. J Immunother Cancer. 2024;12(11).","DOI":"10.1136\/jitc-2024-010248"},{"key":"7887_CR29","doi-asserted-by":"crossref","unstructured":"Xiong C, Huang L, Kou H, Wang C, Zeng X, Sun H, et al. Identification of novel HLA-A11: 01-restricted HPV16 E6\/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy. J Immunother Cancer. 2022;10(9).","DOI":"10.1136\/jitc-2022-004790"},{"issue":"10","key":"7887_CR30","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/s41423-024-01207-0","volume":"21","author":"L Peng","year":"2024","unstructured":"Peng L, Sferruzza G, Yang L, Zhou L, Chen S. CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors. Cellular Mol Immunol. 2024;21(10):1089\u2013108.","journal-title":"Cellular Mol Immunol"},{"key":"7887_CR31","doi-asserted-by":"crossref","unstructured":"Xian Y, Wen L. CAR Beyond \u03b1\u03b2 T cells: unleashing NK cells, macrophages, and \u03b3\u03b4 T lymphocytes against solid tumors. Nato Adv Sci Inst Se. 2025;13(6).","DOI":"10.3390\/vaccines13060654"},{"issue":"1","key":"7887_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41420-024-01815-9","volume":"10","author":"W Wang","year":"2024","unstructured":"Wang W, Liu Y, He Z, Li L, Liu S, Jiang M, et al. Breakthrough of solid tumor treatment: CAR-NK immunotherapy. Cell Death Discov. 2024;10(1):40.","journal-title":"Cell Death Discov"},{"issue":"1","key":"7887_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s40364-023-00537-x","volume":"11","author":"K Hadiloo","year":"2023","unstructured":"Hadiloo K, Taremi S, Heidari M, Esmaeilzadeh A. The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors. Biomarker Res. 2023;11(1):103.","journal-title":"Biomarker Res"},{"key":"7887_CR34","doi-asserted-by":"publisher","first-page":"1615760","DOI":"10.3389\/fimmu.2025.1615760","volume":"16","author":"A Morva","year":"2025","unstructured":"Morva A, Arroyo AB, Andreeva L, Tapia-Abell\u00e1n A, Luengo-Gil G. Unleashing the power of CAR-M therapy in solid tumors: a comprehensive review. Front Immunol. 2025;16:1615760.","journal-title":"Front Immunol"},{"issue":"7","key":"7887_CR35","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1182\/bloodadvances.2024015157","volume":"9","author":"S Shahid","year":"2025","unstructured":"Shahid S, Prockop SE, Flynn GC, Mauguen A, White CO, Bieler J, et al. Allogeneic off-the-shelf CAR T-cell therapy for relapsed or refractory B-cell malignancies. Blood Adv. 2025;9(7):1644\u201357.","journal-title":"Blood Adv"},{"issue":"1","key":"7887_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13045-024-01550-9","volume":"17","author":"Y Kang","year":"2024","unstructured":"Kang Y, Li C, Mei H. Off-the-shelf CAR-T cell therapies for relapsed or refractory B-cell malignancies: latest update from ASH, 2023 annual meeting. J Hematol Oncol. 2024;17(1):29.","journal-title":"J Hematol Oncol"},{"key":"7887_CR37","doi-asserted-by":"publisher","first-page":"927153","DOI":"10.3389\/fimmu.2022.927153","volume":"13","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhu L, Zhang H, Chen S, Xiao Y. CAR-T cell therapy in hematological malignancies: current opportunities and challenges. Front Immunol. 2022;13:927153.","journal-title":"Front Immunol"},{"issue":"12","key":"7887_CR38","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.7150\/ijbs.34213","volume":"15","author":"S Ma","year":"2019","unstructured":"Ma S, Li X, Wang X, Cheng L, Li Z, Zhang C, et al. Current progress in CAR-T cell therapy for solid tumors. Int J Biol Sci. 2019;15(12):2548\u201360.","journal-title":"Int J Biol Sci"},{"key":"7887_CR39","doi-asserted-by":"crossref","unstructured":"Lee A. Obecabtagene autoleucel: first approval, molecular diagnosis & therapy. 2025;29(3):419\u201323.","DOI":"10.1007\/s40291-025-00771-z"},{"issue":"1","key":"7887_CR40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41408-024-01082-y","volume":"14","author":"H Lin","year":"2024","unstructured":"Lin H, Cheng J, Zhu L, Zeng Y, Dai Z, Zhang Y, et al. Anti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control. Blood Cancer J. 2024;14(1):98.","journal-title":"Blood Cancer J"},{"issue":"1","key":"7887_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-024-01602-0","volume":"17","author":"R Tan","year":"2024","unstructured":"Tan R, Li R, Dai MY, Liu M, Zhao J. Redefining chimeric antigen receptor T-cell (CAR-T) regulation: China\u2019s responses to address secondary cancer risks of CAR-T therapy. J Hematol Oncol. 2024;17(1):90.","journal-title":"J Hematol Oncol"},{"issue":"14","key":"7887_CR42","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1056\/NEJMoa2210859","volume":"388","author":"F Del Bufalo","year":"2023","unstructured":"Del Bufalo F, De Angelis B, Caruana I, Del Baldo G, De Ioris MA, Serra A, et al. GD2-CART01 for relapsed or refractory high-risk neuroblastoma. NEJM Evid. 2023;388(14):1284\u201395.","journal-title":"NEJM Evid"},{"issue":"8","key":"7887_CR43","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.ccell.2024.07.002","volume":"42","author":"U Uslu","year":"2024","unstructured":"Uslu U, Castelli S, June CH. CAR T cell combination therapies to treat cancer. Cancer Cell. 2024;42(8):1319\u201325.","journal-title":"Cancer Cell"},{"key":"7887_CR44","doi-asserted-by":"crossref","unstructured":"Doeppner CA, Binder AK, Bremm F, Feuchter N, D\u00f6rrie J, Schaft N. Rendering NK cells antigen-specific for the therapy of solid tumours. Int J Mol Sci. 2025;26(13).","DOI":"10.3390\/ijms26136290"},{"issue":"1","key":"7887_CR45","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41420-024-02077-1","volume":"10","author":"Y Zhong","year":"2024","unstructured":"Zhong Y, Liu J. Emerging roles of CAR-NK cell therapies in tumor immunotherapy: current status and future directions. Cell Death Discov. 2024;10(1):318.","journal-title":"Cell Death Discov"},{"issue":"6","key":"7887_CR46","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1056\/NEJMoa1910607","volume":"382","author":"E Liu","year":"2020","unstructured":"Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, Basar R, et al. Use of CAR-Transduced Natural killer cells in CD19-positive lymphoid tumors. NEJM Evid. 2020;382(6):545\u201353.","journal-title":"NEJM Evid"},{"key":"7887_CR47","doi-asserted-by":"publisher","first-page":"1337557","DOI":"10.3389\/fimmu.2024.1337557","volume":"15","author":"X Lin","year":"2024","unstructured":"Lin X, Guan T, Li Y, Lin Y, Huang G, Lin Y, et al. Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma. Front Immunol. 2024;15:1337557.","journal-title":"Front Immunol"},{"issue":"11","key":"7887_CR48","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1093\/neuonc\/noad087","volume":"25","author":"MC Burger","year":"2023","unstructured":"Burger MC, Forster MT, Romanski A, Stra\u00dfheimer F, Macas J, Zeiner PS, et al. Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma. Neuro-Oncology. 2023;25(11):2058\u201371.","journal-title":"Neuro-Oncology"},{"key":"7887_CR49","doi-asserted-by":"publisher","first-page":"123300","DOI":"10.1016\/j.lfs.2024.123300","volume":"361","author":"Y Shi","year":"2025","unstructured":"Shi Y, Li X, Dong Y, Yuan H, Wang Y, Yang R. Exploring the potential of CAR-macrophage therapy. Life Sci. 2025;361:123300.","journal-title":"Life Sci"},{"key":"7887_CR50","doi-asserted-by":"publisher","first-page":"103873","DOI":"10.1016\/j.ebiom.2022.103873","volume":"76","author":"S Wang","year":"2022","unstructured":"Wang S, Yang Y, Ma P, Zha Y, Zhang J, Lei A, et al. CAR-macrophage: an extensive immune enhancer to fight cancer. EBioMedicine. 2022;76:103873.","journal-title":"EBioMedicine"},{"issue":"21","key":"7887_CR51","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1097\/CM9.0000000000002944","volume":"137","author":"B Yang","year":"2024","unstructured":"Yang B, Wang X, Wei X, Ma J. Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacy. Chin Med J. 2024;137(21):2590\u2013602.","journal-title":"Chin Med J"},{"key":"7887_CR52","doi-asserted-by":"crossref","unstructured":"Liu M, Liu J, Liang Z, Dai K, Gan J, Wang Q, et al. CAR-Macrophages and CAR-T cells synergistically kill tumor cells in vitro. Cells. 2022;11(22).","DOI":"10.3390\/cells11223692"},{"key":"7887_CR53","doi-asserted-by":"crossref","unstructured":"Yarza R, Bover M, Herrera-Juarez M, Rey-Cardenas M, Paz-Ares L, Lopez-Martin JA, et al. Efficacy of T-cell receptor-based adoptive cell therapy in cutaneous melanoma: a meta-analysis. Oncologist. 2023;28(6):e406\u201315.","DOI":"10.1093\/oncolo\/oyad078"},{"issue":"2","key":"7887_CR54","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/neuonc\/noad172","volume":"26","author":"C Kr\u00e4mer","year":"2024","unstructured":"Kr\u00e4mer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, et al. NLGN4X TCR transgenic T cells to treat gliomas. Neuro-oncology. 2024;26(2):266\u201378.","journal-title":"Neuro-oncology"},{"issue":"13","key":"7887_CR55","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1056\/NEJMoa2103485","volume":"385","author":"P Nathan","year":"2021","unstructured":"Nathan P, Hassel JC, Rutkowski P, Baurain JF, Butler MO, Schlaak M, et al. Overall survival benefit with tebentafusp in metastatic uveal melanoma. NEJM Evid. 2021;385(13):1196\u2013206.","journal-title":"NEJM Evid"},{"issue":"5","key":"7887_CR56","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00262-022-03335-w","volume":"72","author":"S Wang","year":"2023","unstructured":"Wang S, Zhang X, Zou X, Wen M, Gan C, Jiang X, et al. Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells. Cancer Immunol Immunother. 2023;72(5):1301\u201313","journal-title":"Cancer Immunol, Immunother: CII"},{"key":"7887_CR57","doi-asserted-by":"crossref","unstructured":"Wang S, Yu G, Dai Y, Gan C, Qiu S, Zhang X, et al. IND-Enabling studies for a TCR-T targeting a pancreatic cancer G12V KRAS mutation. Clin Cancer Res. 2025.","DOI":"10.1158\/1078-0432.c.8126038"},{"key":"7887_CR58","doi-asserted-by":"crossref","unstructured":"Champion PJ, Bluestein JR, Quinn AE, Bell SD, Kiley JH, Wakefield MR, et al. A consolidated review of contemporary targeted and immunotherapeutic options for melanoma. Biomedicines. 2025;13(6).","DOI":"10.3390\/biomedicines13061388"},{"key":"7887_CR59","doi-asserted-by":"crossref","unstructured":"World\u2019s first TIL therapy approved. Nat Biotechnol. 2024;42(3):349.","DOI":"10.1038\/s41587-024-02195-2"},{"key":"7887_CR60","doi-asserted-by":"crossref","unstructured":"Chen Z, Han F, Du Y, Shi H, Zhou W. Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions, signal transduction and targeted therapy. 2023;8(1):70.","DOI":"10.1038\/s41392-023-01332-8"},{"issue":"6","key":"7887_CR61","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","volume":"162","author":"CH Chang","year":"2015","unstructured":"Chang CH, Qiu J, O\u2019Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162(6):1229\u201341.","journal-title":"Cell"},{"issue":"6","key":"7887_CR62","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.celrep.2018.01.040","volume":"22","author":"AV Menk","year":"2018","unstructured":"Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, et al. Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions. Cell Rep. 2018;22(6):1509\u201321.","journal-title":"Cell Rep"},{"key":"7887_CR63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2147\/BTT.S365490","volume":"16","author":"YT Dabi","year":"2022","unstructured":"Dabi YT, Andualem H, Degechisa ST, Gizaw ST. Targeting metabolic reprogramming of T-cells for enhanced anti-tumor response. Biologics Targets Ther. 2022;16:35\u201345.","journal-title":"Biologics Targets Ther"},{"key":"7887_CR64","doi-asserted-by":"publisher","first-page":"1347181","DOI":"10.3389\/fimmu.2024.1347181","volume":"15","author":"L Xuekai","year":"2024","unstructured":"Xuekai L, Yan S, Jian C, Yifei S, Xinyue W, Wenyuan Z, et al. Advances in reprogramming of energy metabolism in tumor T cells. Front Immunol. 2024;15:1347181.","journal-title":"Front Immunol"},{"key":"7887_CR65","doi-asserted-by":"crossref","unstructured":"Corrado M, Pearce EL. Targeting memory T cell metabolism to improve immunity. J Clin Investigation. 2022;132(1).","DOI":"10.1172\/JCI148546"},{"issue":"5","key":"7887_CR66","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.devcel.2016.02.012","volume":"36","author":"AM Hosios","year":"2016","unstructured":"Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, et al. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev Cell. 2016;36(5):540\u201349.","journal-title":"Dev Cell"},{"key":"7887_CR67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mito.2017.10.006","volume":"41","author":"G Desd\u00edn-Mic\u00f3","year":"2018","unstructured":"Desd\u00edn-Mic\u00f3 G, Soto-Heredero G, Mittelbrunn M. Mitochondrial activity in T cells. Mitochondrion. 2018;41:51\u201357.","journal-title":"Mitochondrion"},{"key":"7887_CR68","doi-asserted-by":"crossref","unstructured":"Mah AY, Rashidi A, Keppel MP, Saucier N, Moore EK, Alinger JB, et al. Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control. JCI Insight. 2017;2(23).","DOI":"10.1172\/jci.insight.95128"},{"issue":"7","key":"7887_CR69","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/intimm\/dxaa036","volume":"32","author":"MP Plebanek","year":"2020","unstructured":"Plebanek MP, Sturdivant M, DeVito NC, Hanks BA. Role of dendritic cell metabolic reprogramming in tumor immune evasion. Int Immunol. 2020;32(7):485\u201391.","journal-title":"Int Immunol"},{"issue":"1","key":"7887_CR70","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/08830185.2014.969421","volume":"34","author":"L Zhu","year":"2015","unstructured":"Zhu L, Zhao Q, Yang T, Ding W, Zhao Y. Cellular metabolism and macrophage functional polarization. Int Rev Immunol. 2015;34(1):82\u2013100.","journal-title":"Int Rev Immunol"},{"key":"7887_CR71","doi-asserted-by":"crossref","unstructured":"Li J, Bolyard C, Xin G, Li Z. Targeting metabolic pathways of myeloid cells improves cancer immunotherapy, Frontiers in cell and developmental biology. 2021;9:747863.","DOI":"10.3389\/fcell.2021.747863"},{"issue":"8","key":"7887_CR72","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/CM9.0000000000003046","volume":"137","author":"S Liu","year":"2024","unstructured":"Liu S, Zhao Y, Gao Y, Li F, Zhang Y. Targeting metabolism to improve CAR-T cells therapeutic efficacy. Chin Med J. 2024;137(8):909\u201320.","journal-title":"Chin Med J"},{"issue":"1","key":"7887_CR73","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","volume":"16","author":"M Li","year":"2023","unstructured":"Li M, Yang Y, Xiong L, Jiang P, Wang J, Li C. Metabolism, metabolites, and macrophages in cancer. J Hematol Oncol. 2023;16(1):80.","journal-title":"J Hematol Oncol"},{"issue":"12","key":"7887_CR74","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-020-0793-3","volume":"21","author":"YR Yu","year":"2020","unstructured":"Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, et al. Disturbed mitochondrial dynamics in CD8(+) TILs reinforce T cell exhaustion. Nat Immunol. 2020;21(12):1540\u201351.","journal-title":"Nat Immunol"},{"key":"7887_CR75","doi-asserted-by":"crossref","unstructured":"Hu Z, Yu X, Ding R, Liu B, Gu C, Pan XW, et al. Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. J Clin Investigation. 2023;133(7).","DOI":"10.1172\/JCI166031"},{"key":"7887_CR76","doi-asserted-by":"crossref","unstructured":"Barba I, Carrillo-Bosch L, Seoane J. Targeting the Warburg effect in cancer: where do we stand? Int J Mol Sci. 2024;25(6).","DOI":"10.3390\/ijms25063142"},{"issue":"7","key":"7887_CR77","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1172\/JCI131859","volume":"130","author":"MH Oh","year":"2020","unstructured":"Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, et al. Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells. J Clin Investigation. 2020;130(7):3865\u201384.","journal-title":"J Clin Investigation"},{"issue":"7851","key":"7887_CR78","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","volume":"591","author":"MJ Watson","year":"2021","unstructured":"Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. 2021;591(7851):645\u201351.","journal-title":"Nature"},{"issue":"7","key":"7887_CR79","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.cmet.2023.06.003","volume":"35","author":"W Zou","year":"2023","unstructured":"Zou W, Green DR. Beggars banquet: metabolism in the tumor immune microenvironment and cancer therapy. Cell Metab. 2023;35(7):1101\u201313.","journal-title":"Cell Metab"},{"issue":"4","key":"7887_CR80","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00262-019-02457-y","volume":"69","author":"X Li","year":"2020","unstructured":"Li X, Zhang Y, Ma W, Fu Q, Liu J, Yin G, et al. Enhanced glucose metabolism mediated by CD147 contributes to immunosuppression in hepatocellular carcinoma. Cancer Immunol, Immunother: CII. 2020;69(4):535\u201348.","journal-title":"Cancer Immunol, Immunother: CII"},{"key":"7887_CR81","doi-asserted-by":"crossref","unstructured":"Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, et al. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8(+) T cells. Sci Immunol. 2019;4(31).","DOI":"10.1126\/sciimmunol.aap9520"},{"key":"7887_CR82","doi-asserted-by":"crossref","unstructured":"Verma S, Budhu S, Serganova I, Dong L, Mangarin LM, Khan JF, et al. Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models. J Clin Investigation. 2024;134(17).","DOI":"10.1172\/JCI177606"},{"issue":"2","key":"7887_CR83","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","volume":"22","author":"NE Scharping","year":"2021","unstructured":"Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, et al. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol. 2021;22(2):205\u201315.","journal-title":"Nat Immunol"},{"key":"7887_CR84","doi-asserted-by":"crossref","unstructured":"Kennedy PR, Arvindam US, Phung SK, Ettestad B, Feng X, Li Y, et al. Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments. Sci Adv. 2024;10(44):eadn 1849.","DOI":"10.1126\/sciadv.adn1849"},{"key":"7887_CR85","doi-asserted-by":"crossref","unstructured":"Zhou J, Gu J, Qian Q, Zhang Y, Huang T, Li X, et al. Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria. J Clin Investigation. 2024;134(20).","DOI":"10.1172\/JCI175897"},{"issue":"12","key":"7887_CR86","doi-asserted-by":"publisher","first-page":"110986","DOI":"10.1016\/j.celrep.2022.110986","volume":"39","author":"J Gu","year":"2022","unstructured":"Gu J, Zhou J, Chen Q, Xu X, Gao J, Li X, et al. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-\u03b2 signaling in regulatory T cells. Cell Rep. 2022;39(12):110986.","journal-title":"Cell Rep"},{"issue":"1","key":"7887_CR87","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13046-023-02845-4","volume":"42","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Yao Y, Ge T, Ge S, Jia R, Song X, et al. Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity. J Exp Clin Cancer Res. 2023;42(1):291.","journal-title":"J Exp Clin Cancer Res"},{"issue":"7","key":"7887_CR88","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.tips.2023.04.006","volume":"44","author":"TW Stone","year":"2023","unstructured":"Stone TW, Williams RO. Modulation of T cells by tryptophan metabolites in the kynurenine pathway. Trends Pharmacological Sci. 2023;44(7):442\u201356.","journal-title":"Trends Pharmacological Sci"},{"issue":"1","key":"7887_CR89","doi-asserted-by":"publisher","first-page":"1956143","DOI":"10.1080\/2162402X.2021.1956143","volume":"10","author":"A Sosnowska","year":"2021","unstructured":"Sosnowska A, Chlebowska-Tuz J, Matryba P, Pilch Z, Greig A, Wolny A, et al. Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. Oncoimmunology. 2021;10(1):1956143.","journal-title":"Oncoimmunology"},{"key":"7887_CR90","doi-asserted-by":"crossref","unstructured":"Jaune-Pons E, Vasseur S. Role of amino acids in regulation of ROS balance in cancer. Arch Biochem Biophys. 2020;689. 108438.","DOI":"10.1016\/j.abb.2020.108438"},{"issue":"7972","key":"7887_CR91","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41586-023-06299-8","volume":"620","author":"C Guo","year":"2023","unstructured":"Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, et al. SLC38A2 and glutamine signalling in cDc1s dictate anti-tumour immunity. Nature. 2023;620(7972):200\u201308.","journal-title":"Nature"},{"issue":"1","key":"7887_CR92","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40170-025-00393-3","volume":"13","author":"H Yin","year":"2025","unstructured":"Yin H, Shan Y, Zhu Q, Yuan L, Ju F, Shi Y, et al. Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells. Cancer Metab. 2025;13(1):24.","journal-title":"Cancer Metab"},{"issue":"1","key":"7887_CR93","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13045-021-01200-4","volume":"14","author":"W Yu","year":"2021","unstructured":"Yu W, Lei Q, Yang L, Qin G, Liu S, Wang D, et al. Contradictory roles of lipid metabolism in immune response within the tumor microenvironment. J Hematol Oncol. 2021;14(1):187.","journal-title":"J Hematol Oncol"},{"issue":"2","key":"7887_CR94","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jhep.2024.03.016","volume":"81","author":"L Xu","year":"2024","unstructured":"Xu L, Zhang Y, Lin Z, Deng X, Ren X, Huang M, et al. FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma. J Educ Chang Hepatol. 2024;81(2):265\u201377.","journal-title":"J Educ Chang Hepatol"},{"key":"7887_CR95","doi-asserted-by":"crossref","unstructured":"Vecchi L, Ara\u00fajo TG, Azevedo F, Mota STS, \u00c1vila VMR, Ribeiro MA, et al. Phospholipase A(2) drives tumorigenesis and cancer aggressiveness through its interaction with annexin A1. Cells. 2021;10(6).","DOI":"10.3390\/cells10061472"},{"issue":"1","key":"7887_CR96","doi-asserted-by":"publisher","first-page":"2085432","DOI":"10.1080\/2162402X.2022.2085432","volume":"11","author":"Z Liu","year":"2022","unstructured":"Liu Z, Gao Z, Li B, Li J, Ou Y, Yu X, et al. Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. Oncoimmunology. 2022;11(1):2085432.","journal-title":"Oncoimmunology"},{"issue":"6","key":"7887_CR97","first-page":"188984","volume":"1878","author":"S Goswami","year":"2023","unstructured":"Goswami S, Zhang Q, Celik CE, Reich EM, Yilmaz \u00d6H. Dietary fat and lipid metabolism in the tumor microenvironment, Biochimica et biophysica acta. Rev Cancer. 2023;1878(6):188984.","journal-title":"Rev Cancer"},{"issue":"11","key":"7887_CR98","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1038\/s41423-024-01224-z","volume":"21","author":"Y Tang","year":"2024","unstructured":"Tang Y, Chen Z, Zuo Q, Kang Y. Regulation of CD8+ T cells by lipid metabolism in cancer progression. Cellular Mol Immunol. 2024;21(11):1215\u201330.","journal-title":"Cellular Mol Immunol"},{"key":"7887_CR99","doi-asserted-by":"crossref","unstructured":"Bietz A, Zhu H, Xue M, Xu C. Cholesterol metabolism in T cells, Frontiers in immunology. 1664;8(2017).","DOI":"10.3389\/fimmu.2017.01664"},{"issue":"7596","key":"7887_CR100","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature17412","volume":"531","author":"W Yang","year":"2016","unstructured":"Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, et al. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature. 2016;531(7596):651\u201355.","journal-title":"Nature"},{"key":"7887_CR101","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jare.2024.02.009","volume":"68","author":"N Shao","year":"2025","unstructured":"Shao N, Qiu H, Liu J, Xiao D, Zhao J, Chen C, et al. Targeting lipid metabolism of macrophages: a new strategy for tumor therapy. J Adv Res. 2025;68:99\u2013114.","journal-title":"J Adv Res"},{"issue":"7","key":"7887_CR102","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1158\/0008-5472.CAN-19-2994","volume":"80","author":"P Su","year":"2020","unstructured":"Su P, Wang Q, Bi E, Ma X, Liu L, Yang M, et al. Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages. Cancer Res. 2020;80(7):1438\u201350.","journal-title":"Cancer Res"},{"key":"7887_CR103","doi-asserted-by":"publisher","first-page":"115574","DOI":"10.1016\/j.biopha.2023.115574","volume":"167","author":"Z Sun","year":"2023","unstructured":"Sun Z, Zhang L, Liu L. Reprogramming the lipid metabolism of dendritic cells in tumor immunomodulation and immunotherapy. Biomed Pharmacother. 2023;167:115574.","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"7887_CR104","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.cmet.2023.07.001","volume":"35","author":"L Wu","year":"2023","unstructured":"Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, et al. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-\u03b1. Cell Metab. 2023;35(9):1580\u201396.e9.","journal-title":"Cell Metab"},{"key":"7887_CR105","doi-asserted-by":"publisher","first-page":"1186383","DOI":"10.3389\/fimmu.2023.1186383","volume":"14","author":"W Li","year":"2023","unstructured":"Li W, Pan X, Chen L, Cui H, Mo S, Pan Y, et al. Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy. Front Immunol. 2023;14:1186383.","journal-title":"Front Immunol"},{"key":"7887_CR106","doi-asserted-by":"crossref","unstructured":"Hu W, Li F, Liang Y, Liu S, Wang S, Shen C, et al. Glut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors. J Immunother Cancer. 2025;13(1).","DOI":"10.1136\/jitc-2024-010540"},{"key":"7887_CR107","doi-asserted-by":"crossref","unstructured":"Yao L, Yang H, Shan F, Niu X, Wang Y, Zhang H, et al. T cell glycoengineering to modulate immune-tumor crosstalk: a universal non-genetic strategy for enhanced tumor immunotherapy. Adv Sci (Weinh). 2025;e05387.","DOI":"10.1002\/advs.202505387"},{"issue":"1","key":"7887_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1886844","volume":"13","author":"AH Mohseni","year":"2021","unstructured":"Mohseni AH, Casolaro V, Berm\u00fadez-Humar\u00e1n LG, Keyvani H, Taghinezhad SS. Modulation of the PI3K\/Akt\/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut Microbes. 2021;13(1):1\u201317.","journal-title":"Gut Microbes"},{"issue":"13","key":"7887_CR109","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.7150\/ijbs.99682","volume":"21","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Xu S, Shao J, Lu Y, Zhao L, Liang X, et al. TRAF2 promotes Liver fibrosis via regulation of the HIF-1\u03b1\/GLUT1-mediated glycolysis in hepatic stellate cells. Int J Biol Sci. 2025;21(13):5645\u201365.","journal-title":"Int J Biol Sci"},{"issue":"1","key":"7887_CR110","doi-asserted-by":"publisher","first-page":"9394","DOI":"10.1038\/s41467-024-53593-8","volume":"15","author":"H Shen","year":"2024","unstructured":"Shen H, Ojo OA, Ding H, Mullen LJ, Xing C, Hossain MI, et al. HIF1\u03b1-regulated glycolysis promotes activation-induced cell death and IFN-\u03b3 induction in hypoxic T cells. Nat Commun. 2024;15(1):9394.","journal-title":"Nat Commun"},{"issue":"6","key":"7887_CR111","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.cell.2015.08.012","volume":"162","author":"PC Ho","year":"2015","unstructured":"Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell. 2015;162(6):1217\u201328.","journal-title":"Cell"},{"key":"7887_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmet.2018.11.013","volume":"20","author":"M Yi","year":"2019","unstructured":"Yi M, Ban Y, Tan Y, Xiong W, Li G, Xiang B. 6-Phosphofructo-2-kinase\/fructose-2, 6-biphosphatase 3 and 4: a pair of valves for fine-tuning of glucose metabolism in human cancer. Mol Metab. 2019;20:1\u201313.","journal-title":"Mol Metab"},{"key":"7887_CR113","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1479-5876-10-95","volume":"10","author":"S Telang","year":"2012","unstructured":"Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, et al. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J Retailing Transl Med. 2012;10:95.","journal-title":"J Retailing Transl Med"},{"issue":"3","key":"7887_CR114","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s11427-022-2170-2","volume":"66","author":"Q Wen","year":"2023","unstructured":"Wen Q, Xu ZL, Wang Y, Lv M, Song Y, Lyv ZS, et al. Glucocorticoid and glycolysis inhibitors cooperatively abrogate acute graft-versus-host disease, Science China. Life Sci. 2023;66(3):528\u201344.","journal-title":"Life Sci"},{"issue":"7","key":"7887_CR115","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.4049\/jimmunol.1600474","volume":"197","author":"H Jiang","year":"2016","unstructured":"Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, et al. PFKFB3-driven macrophage glycolytic metabolism is a crucial component of innate antiviral defense. J Immuno. 2016;197(7):2880\u201390.","journal-title":"J Immuno"},{"issue":"3","key":"7887_CR116","first-page":"189089","volume":"1879","author":"S Upadhyay","year":"2024","unstructured":"Upadhyay S, Khan S, Hassan MI. Exploring the diverse role of pyruvate kinase M2 in cancer: navigating beyond glycolysis and the Warburg effect, Biochimica et biophysica acta. Rev Cancer. 2024;1879(3):189089.","journal-title":"Rev Cancer"},{"key":"7887_CR117","doi-asserted-by":"publisher","first-page":"216964","DOI":"10.1016\/j.canlet.2024.216964","volume":"593","author":"Y Yu","year":"2024","unstructured":"Yu Y, Liang Y, Xie F, Zhang Z, Zhang P, Zhao X, et al. Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation. Cancer Lett. 2024;593:216964.","journal-title":"Cancer Lett"},{"key":"7887_CR118","doi-asserted-by":"crossref","unstructured":"Puckett DL, Alquraishi M, Chowanadisai W, Bettaieb A. The role of PKM2 in metabolic reprogramming: insights into the regulatory roles of non-coding RNAs. Int J Mol Sci. 2021;22(3).","DOI":"10.3390\/ijms22031171"},{"issue":"12","key":"7887_CR119","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1111\/febs.17423","volume":"292","author":"M Iozzo","year":"2025","unstructured":"Iozzo M, Comito G, Ippolito L, Sandrini G, Pardella E, Pranzini E, et al. Sex-related changes in lactate dehydrogenase a expression differently impact the immune response in melanoma. The FEBS J. 2025;292(12):3056\u201371.","journal-title":"The FEBS J"},{"key":"7887_CR120","doi-asserted-by":"publisher","first-page":"1563303","DOI":"10.3389\/fimmu.2025.1563303","volume":"16","author":"XY Gu","year":"2025","unstructured":"Gu XY, Yang JL, Lai R, Zhou ZJ, Tang D, Hu L, et al. Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives. Front Immunol. 2025;16:1563303.","journal-title":"Front Immunol"},{"issue":"6311","key":"7887_CR121","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.aaf6284","volume":"354","author":"M Peng","year":"2016","unstructured":"Peng M, Yin N, Chhangawala S, Xu K, Leslie CS, Li MO. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016;354(6311):481\u201384.","journal-title":"Science"},{"issue":"7","key":"7887_CR122","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.4049\/jimmunol.180.7.4476","volume":"180","author":"SR Jacobs","year":"2008","unstructured":"Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immuno. 2008;180(7):4476\u201386.","journal-title":"J Immuno"},{"issue":"1","key":"7887_CR123","doi-asserted-by":"publisher","first-page":"6858","DOI":"10.1038\/s41467-023-42634-3","volume":"14","author":"H Wu","year":"2023","unstructured":"Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Kn\u00f6pper K, et al. Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1\u03b1-mediated glycolytic reprogramming. Nat Commun. 2023;14(1):6858.","journal-title":"Nat Commun"},{"key":"7887_CR124","doi-asserted-by":"crossref","unstructured":"Li F, Feng Y, Yin Z, Wang Y. Mitochondrial metabolism in T-Cell exhaustion. Int J Mol Sci. 2025;26(15).","DOI":"10.3390\/ijms26157400"},{"key":"7887_CR125","doi-asserted-by":"crossref","unstructured":"Hao ZN, Tan XP, Zhang Q, Li J, Xia R, Ma Z. Lactate and lactylation: dual regulators of T-Cell-mediated tumor immunity and immunotherapy. Biomolecules. 2024;14(12).","DOI":"10.3390\/biom14121646"},{"issue":"25","key":"7887_CR126","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1038\/s41388-025-03458-1","volume":"44","author":"J Saravia","year":"2025","unstructured":"Saravia J, Chi H. Immunometabolism of regulatory T cells in cancer. Oncogene. 2025;44(25):2011\u201324.","journal-title":"Oncogene"},{"key":"7887_CR127","doi-asserted-by":"publisher","first-page":"108994","DOI":"10.1016\/j.intimp.2022.108994","volume":"110","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang X, Meng Y, Xu X, Zuo D. The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype. Int Immunopharmacol. 2022;110:108994.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"7887_CR128","doi-asserted-by":"publisher","first-page":"111516","DOI":"10.1016\/j.celrep.2022.111516","volume":"41","author":"A Kumar","year":"2022","unstructured":"Kumar A, Yarosz EL, Andren A, Zhang L, Lyssiotis CA, Chang CH. NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function. Cell Rep. 2022;41(4):111516.","journal-title":"Cell Rep"},{"issue":"1","key":"7887_CR129","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12964-022-00909-0","volume":"20","author":"G Ma","year":"2022","unstructured":"Ma G, Zhang Z, Li P, Zhang Z, Zeng M, Liang Z, et al. Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment. Cell Commun Signaling. 2022;20(1):114.","journal-title":"Cell Commun Signaling"},{"key":"7887_CR130","doi-asserted-by":"publisher","first-page":"1221530","DOI":"10.3389\/fimmu.2023.1221530","volume":"14","author":"T Liu","year":"2023","unstructured":"Liu T, Ren S, Sun C, Zhao P, Wang H. Glutaminolysis and peripheral CD4(+) T cell differentiation: from mechanism to intervention strategy. Front Immunol. 2023;14:1221530.","journal-title":"Front Immunol"},{"issue":"7727","key":"7887_CR131","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41586-018-0597-x","volume":"562","author":"M Song","year":"2018","unstructured":"Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, et al. IRE1\u03b1-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature. 2018;562(7727):423\u201328.","journal-title":"Nature"},{"issue":"5","key":"7887_CR132","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.cell.2021.02.021","volume":"184","author":"H Huang","year":"2021","unstructured":"Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, et al. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions. Cell. 2021;184(5):1245\u201361.e21.","journal-title":"Cell"},{"key":"7887_CR133","doi-asserted-by":"crossref","unstructured":"Zheng S, Liu T, Li L, Liu Q, Huang C, Liang Y, et al. SLC1A5, unrelated to prognosis, was associated with CD8(+) T-cell exclusion in the tumor microenvironment of squamous cell carcinoma. Heliyon. 2023;9(3):e14571.","DOI":"10.1016\/j.heliyon.2023.e14571"},{"issue":"1","key":"7887_CR134","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","volume":"11","author":"LF Campesato","year":"2020","unstructured":"Campesato LF, Budhu S, Tchaicha J, Weng CH, Gigoux M, Cohen IJ, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11(1):4011.","journal-title":"Nat Commun"},{"issue":"1","key":"7887_CR135","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40364-023-00487-4","volume":"11","author":"W Sun","year":"2023","unstructured":"Sun W, Liu R, Gao X, Lin Z, Tang H, Cui H, et al. Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers. Biomarker Res. 2023;11(1):48.","journal-title":"Biomarker Res"},{"key":"7887_CR136","doi-asserted-by":"crossref","unstructured":"Hope HC, Salmond RJ. The role of non-essential amino acids in T cell function and anti-tumour immunity, archivum immunologiae et therapiae experimentalis. 2021;69(1):29.","DOI":"10.1007\/s00005-021-00633-6"},{"issue":"12","key":"7887_CR137","first-page":"769","volume":"21","author":"JD Chan","year":"2021","unstructured":"Chan JD, Lai J, Slaney CY, Kallies A, Beavis PA, Darcy PK. Cellular networks controlling T cell persistence in adoptive cell therapy. Nat Rev Immunology. 2021;21(12):769\u201384.","journal-title":"Immunology"},{"issue":"2","key":"7887_CR138","first-page":"594","volume":"123","author":"E Lugli","year":"2013","unstructured":"Lugli E, Dominguez MH, Gattinoni L, Chattopadhyay PK, Bolton DL, Song K, et al. Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Investigation. 2013;123(2):594\u201399.","journal-title":"J Clin Investigation"},{"issue":"1","key":"7887_CR139","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1172\/JCI32103","volume":"118","author":"C Berger","year":"2008","unstructured":"Berger C, Jensen MC, Lansdorp PM, Gough M, Elliott C, Riddell SR. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Investigation. 2008;118(1):294\u2013305.","journal-title":"J Clin Investigation"},{"issue":"1","key":"7887_CR140","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","volume":"36","author":"GJ van der Windt","year":"2012","unstructured":"van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity. 2012;36(1):68\u201378.","journal-title":"Immunity"},{"issue":"1","key":"7887_CR141","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.1038\/s41467-021-24619-2","volume":"12","author":"J He","year":"2021","unstructured":"He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, et al. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nat Commun. 2021;12(1):4371.","journal-title":"Nat Commun"},{"issue":"7","key":"7887_CR142","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/s41423-020-0365-3","volume":"18","author":"N Dumauthioz","year":"2021","unstructured":"Dumauthioz N, Tschumi B, Wenes M, Marti B, Wang H, Franco F, et al. Enforced PGC-1\u03b1 expression promotes CD8 T cell fitness, memory formation and antitumor immunity. Cellular Mol Immunol. 2021;18(7):1761\u201371.","journal-title":"Cellular Mol Immunol"},{"issue":"11","key":"7887_CR143","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1158\/2326-6066.CIR-18-0095","volume":"6","author":"PS Chowdhury","year":"2018","unstructured":"Chowdhury PS, Chamoto K, Kumar A, Honjo T. PPAR-Induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8(+) T cells and facilitates anti-PD-1 therapy. Cancer Immunol Res. 2018;6(11):1375\u201387.","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"7887_CR144","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.immuni.2016.07.009","volume":"45","author":"NE Scharping","year":"2016","unstructured":"Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity. 2016;45(2):374\u201388.","journal-title":"Immunity"},{"issue":"6","key":"7887_CR145","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.cmet.2020.11.004","volume":"32","author":"W Li","year":"2020","unstructured":"Li W, Cheng H, Li G, Zhang L. Mitochondrial damage and the Road to exhaustion. Cell Metab. 2020;32(6):905\u201307.","journal-title":"Cell Metab"},{"issue":"9","key":"7887_CR146","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/s41590-020-0725-2","volume":"21","author":"SA Vardhana","year":"2020","unstructured":"Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, et al. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nat Immunol. 2020;21(9):1022\u201333.","journal-title":"Nat Immunol"},{"issue":"7764","key":"7887_CR147","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","volume":"571","author":"O Khan","year":"2019","unstructured":"Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, et al. TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion. Nature. 2019;571(7764):211\u201318.","journal-title":"Nature"},{"issue":"7749","key":"7887_CR148","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41586-019-0985-x","volume":"567","author":"J Chen","year":"2019","unstructured":"Chen J, L\u00f3pez-Moyado IF, Seo H, Lio CJ, Hempleman LJ, Sekiya T, et al. NR4A transcription factors limit CAR T cell function in solid tumours. Nature. 2019;567(7749):530\u201334.","journal-title":"Nature"},{"issue":"1","key":"7887_CR149","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","volume":"18","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Zhang J, Zheng Y, Zhang Y, Zhang XJ, Wang H, et al. NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway. J Neuroinflammation. 2021;18(1):207.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"7887_CR150","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13045-022-01255-x","volume":"15","author":"Y Huang","year":"2022","unstructured":"Huang Y, Si X, Shao M, Teng X, Xiao G, Huang H. Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells. J Hematol Oncol. 2022;15(1):38.","journal-title":"J Hematol Oncol"},{"issue":"3","key":"7887_CR151","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/febs.16296","volume":"290","author":"X Zhou","year":"2023","unstructured":"Zhou X, Zhu X, Zeng H. Fatty acid metabolism in adaptive immunity. The FEBS J. 2023;290(3):584\u201399.","journal-title":"The FEBS J"},{"issue":"7","key":"7887_CR152","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.immuni.2021.05.003","volume":"54","author":"S Xu","year":"2021","unstructured":"Xu S, Chaudhary O, Rodr\u00edguez-Morales P, Sun X, Chen D, Zappasodi R, et al. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Immunity. 2021;54(7):1561\u201377.e7.","journal-title":"Immunity"},{"issue":"2","key":"7887_CR153","first-page":"189259","volume":"1880","author":"L Yang","year":"2025","unstructured":"Yang L, Wang X, Wang S, Shen J, Li Y, Wan S, et al. Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy. Biochim Biophys Acta Rev Cancer. 2025;1880(2):189259.","journal-title":"Rev Cancer"},{"issue":"1","key":"7887_CR154","first-page":"45","volume":"52","author":"K Zhao","year":"2021","unstructured":"Zhao K, Shi RC, Miao HM. [A review of the lipid metabolism reprogramming in tumor associated macrophages]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2021;52(1):45\u201349.","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"7887_CR155","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/imr.12655","volume":"283","author":"B Raud","year":"2018","unstructured":"Raud B, McGuire PJ, Jones RG, Sparwasser T, Berod L. Fatty acid metabolism in CD8(+) T cell memory: challenging current concepts. Immunological Rev. 2018;283(1):213\u201331.","journal-title":"Immunological Rev"},{"key":"7887_CR156","doi-asserted-by":"crossref","unstructured":"Xiao L, Ma X, Ye L, Su P, Xiong W, Bi E, et al. IL-9\/STAT3\/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity. J Clin Investigation. 2022;132(7).","DOI":"10.1172\/JCI153247"},{"issue":"24","key":"7887_CR157","doi-asserted-by":"publisher","first-page":"7726","DOI":"10.1111\/febs.16181","volume":"289","author":"W Zeng","year":"2022","unstructured":"Zeng W, Yin X, Jiang Y, Jin L, Liang W. PPAR\u03b1 at the crossroad of metabolic-immune regulation in cancer. FEBS J. 2022;289(24):7726\u201339.","journal-title":"The FEBS J"},{"issue":"2","key":"7887_CR158","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s42255-018-0025-4","volume":"1","author":"Y Endo","year":"2019","unstructured":"Endo Y, Onodera A, Obata-Ninomiya K, Koyama-Nasu R, Asou HK, Ito T, et al. ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis. Nat Metab. 2019;1(2):261\u201375.","journal-title":"Nat Metab"},{"key":"7887_CR159","doi-asserted-by":"publisher","first-page":"613492","DOI":"10.3389\/fimmu.2021.613492","volume":"12","author":"X Peng","year":"2021","unstructured":"Peng X, He Y, Huang J, Tao Y, Liu S. Metabolism of dendritic cells in tumor microenvironment: for immunotherapy. Front Immunol. 2021;12:613492.","journal-title":"Front Immunol"},{"issue":"6","key":"7887_CR160","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.4049\/jimmunol.1302801","volume":"192","author":"R Ramakrishnan","year":"2014","unstructured":"Ramakrishnan R, Tyurin VA, Veglia F, Condamine T, Amoscato A, Mohammadyani D, et al. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immuno. 2014;192(6):2920\u201331.","journal-title":"J Immuno"},{"issue":"7","key":"7887_CR161","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.ccell.2023.04.016","volume":"41","author":"C Yan","year":"2023","unstructured":"Yan C, Zheng L, Jiang S, Yang H, Guo J, Jiang LY, et al. Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity. Cancer Cell. 2023;41(7):1276\u201393.e11.","journal-title":"Cancer Cell"},{"issue":"1","key":"7887_CR162","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cmet.2019.04.002","volume":"30","author":"X Ma","year":"2019","unstructured":"Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, et al. Cholesterol induces CD8(+) T cell exhaustion in the tumor microenvironment. Cell Metab. 2019;30(1):143\u201356.e5.","journal-title":"Cell Metab"},{"issue":"1","key":"7887_CR163","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s40164-025-00719-3","volume":"14","author":"X Ji","year":"2025","unstructured":"Ji X, Xia L. Lactate and lactylation in cancer: drivers of immune suppression and microenvironmental reprogramming. Exp Hematol Oncol. 2025;14(1):128.","journal-title":"Exp Hematol Oncol"},{"issue":"1","key":"7887_CR164","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s13046-023-02815-w","volume":"42","author":"T Sun","year":"2023","unstructured":"Sun T, Liu B, Li Y, Wu J, Cao Y, Yang S, et al. Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation. J Exp Clin Cancer Res. 2023;42(1):253.","journal-title":"J Exp Clin Cancer Res"},{"key":"7887_CR165","doi-asserted-by":"crossref","unstructured":"Lopez E, Karattil R, Nannini F, Weng-Kit Cheung G, Denzler L, Galvez-Cancino F, et al. Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies. J Immunother Cancer. 2023;11(6).","DOI":"10.1136\/jitc-2022-006287"},{"issue":"6","key":"7887_CR166","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.cmet.2025.03.003","volume":"37","author":"SS Mortazavi Farsani","year":"2025","unstructured":"Mortazavi Farsani SS, Soni J, Jin L, Yadav AK, Bansal S, Mi T, et al. Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy. Cell Metab. 2025;37(6):1294\u2013310.e7.","journal-title":"Cell Metab"},{"issue":"1","key":"7887_CR167","doi-asserted-by":"publisher","first-page":"4665","DOI":"10.1038\/s41467-024-49059-6","volume":"15","author":"X Tang","year":"2024","unstructured":"Tang X, Mao X, Ling P, Yu M, Pan H, Wang J, et al. Glycolysis inhibition induces anti-tumor central memory CD8(+)T cell differentiation upon combination with microwave ablation therapy. Nat Commun. 2024;15(1):4665.","journal-title":"Nat Commun"},{"issue":"1","key":"7887_CR168","doi-asserted-by":"publisher","first-page":"6700","DOI":"10.1038\/s41467-025-61939-z","volume":"16","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wang Y, Xing Z, Li D, Wang R, Chen B, et al. Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex. Nat Commun. 2025;16(1):6700.","journal-title":"Nat Commun"},{"issue":"5","key":"7887_CR169","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.cmet.2022.03.013","volume":"34","author":"M Wenes","year":"2022","unstructured":"Wenes M, Jaccard A, Wyss T, Maldonado-P\u00e9rez N, Teoh ST, Lepez A, et al. The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function. Cell Metab. 2022;34(5):731\u201346.e9.","journal-title":"Cell Metab"},{"issue":"1","key":"7887_CR170","doi-asserted-by":"publisher","first-page":"8658","DOI":"10.1038\/s41467-024-52666-y","volume":"15","author":"JA Guerrero","year":"2024","unstructured":"Guerrero JA, Klysz DD, Chen Y, Malipatlolla M, Lone J, Fowler C, et al. GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency. Nat Commun. 2024;15(1):8658.","journal-title":"Nat Commun"},{"key":"7887_CR171","unstructured":"Valenti\u0107 B, Kelly A, Shestov AA, Gan Z, Shen F, Chatoff A, et al. O\u2019Connor, the glucose transporter 5 enhances CAR-T cell metabolic function and anti-tumour durability. Res Sq. 2024."},{"issue":"2","key":"7887_CR172","doi-asserted-by":"publisher","first-page":"382","DOI":"10.4161\/auto.27345","volume":"10","author":"Z Yang","year":"2014","unstructured":"Yang Z, Goronzy JJ, Weyand CM. The glycolytic enzyme PFKFB3\/phosphofructokinase regulates autophagy. Autophagy. 2014;10(2):382\u201383.","journal-title":"Autophagy"},{"issue":"1","key":"7887_CR173","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.1038\/s41467-023-41016-z","volume":"14","author":"S Inamdar","year":"2023","unstructured":"Inamdar S, Suresh AP, Mangal JL, Ng ND, Sundem A, Wu C, et al. Acharya, rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice. Nat Commun. 2023;14(1):5333.","journal-title":"Nat Commun"},{"issue":"3","key":"7887_CR174","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1158\/0008-5472.CAN-17-3053","volume":"79","author":"SD Saibil","year":"2019","unstructured":"Saibil SD, St Paul M, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, et al. Activation of Peroxisome Proliferator-activated receptors \u03b1 and \u03b4 synergizes with inflammatory signals to enhance adoptive cell therapy. Cancer Res. 2019;79(3):445\u201351.","journal-title":"Cancer Res"},{"key":"7887_CR175","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.2147\/OTT.S154853","volume":"11","author":"Q Mu","year":"2018","unstructured":"Mu Q, Jiang M, Zhang Y, Wu F, Li H, Zhang W, et al. Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells. OncoTargets Ther. 2018;11:1767\u201376.","journal-title":"OncoTargets Ther"},{"issue":"21","key":"7887_CR176","doi-asserted-by":"publisher","first-page":"6026","DOI":"10.1158\/1078-0432.CCR-21-0452","volume":"27","author":"Z Nian","year":"2021","unstructured":"Nian Z, Zheng X, Dou Y, Du X, Zhou L, Fu B, et al. Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells. Clin Cancer Res. 2021;27(21):6026\u201338.","journal-title":"Clin Cancer Res: Off J Am Assoc Cancer Res"},{"key":"7887_CR177","doi-asserted-by":"crossref","unstructured":"Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, et al. Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment. JCI Insight. 2024;9(7).","DOI":"10.1172\/jci.insight.177141"},{"issue":"1","key":"7887_CR178","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/cas.15999","volume":"115","author":"T Sugi","year":"2024","unstructured":"Sugi T, Katoh Y, Ikeda T, Seta D, Iwata T, Nishio H, et al. SCD1 inhibition enhances the effector functions of CD8(+) T cells via ACAT1-dependent reduction of esterified cholesterol. Cancer Sci. 2024;115(1):48\u201358.","journal-title":"Cancer Sci"},{"key":"7887_CR179","doi-asserted-by":"crossref","unstructured":"Su Q, Yao J, Farooq MA, Ajmal I, Duan Y, He C, et al. Modulating cholesterol metabolism via ACAT1 knockdown enhances anti-B-Cell lymphoma activities of CD19-specific chimeric antigen receptor T cells by improving the cell activation and proliferation. Cells. 2024;13(6).","DOI":"10.3390\/cells13060555"},{"issue":"1","key":"7887_CR180","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s11658-024-00561-1","volume":"29","author":"X Chen","year":"2024","unstructured":"Chen X, Zhong S, Zhan Y, Zhang X. CRISPR-Cas9 applications in T cells and adoptive T cell therapies. Cell Mol Biol Lett. 2024;29(1):52.","journal-title":"Cellular Mol Biol Lett"},{"issue":"1","key":"7887_CR181","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12967-025-06276-x","volume":"23","author":"Z Wu","year":"2025","unstructured":"Wu Z, Wang H, Zheng Z, Lin Y, Bian L, Geng H, et al. IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment. J Retailing Transl Med. 2025;23(1):275.","journal-title":"J Retailing Transl Med"},{"key":"7887_CR182","doi-asserted-by":"publisher","first-page":"617699","DOI":"10.3389\/fimmu.2020.617699","volume":"11","author":"V Vonwirth","year":"2020","unstructured":"Vonwirth V, B\u00fclb\u00fcl Y, Werner A, Echchannaoui H, Windschmitt J, Habermeier A, et al. Inhibition of arginase 1 liberates potent T cell immunostimulatory activity of human neutrophil granulocytes. Front Immunol. 2020;11:617699.","journal-title":"Front Immunol"},{"issue":"3","key":"7887_CR183","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1158\/1535-7163.MCT-20-0430","volume":"20","author":"S Varghese","year":"2021","unstructured":"Varghese S, Pramanik S, Williams LJ, Hodges HR, Hudgens CW, Fischer GM, et al. The glutaminase inhibitor CB-839 (telaglenastat) enhances the antimelanoma activity of T-cell-mediated immunotherapies. Mol Cancer Ther. 2021;20(3):500\u201311.","journal-title":"Mol Cancer Ther"},{"issue":"10","key":"7887_CR184","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1182\/blood.2019004500","volume":"136","author":"L Fultang","year":"2020","unstructured":"Fultang L, Booth S, Yogev O, Martins da Costa B, Tubb V, Panetti S, et al. Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. Blood. 2020;136(10):1155\u201360.","journal-title":"Blood"},{"issue":"1","key":"7887_CR185","doi-asserted-by":"publisher","first-page":"2055703","DOI":"10.1080\/2162402X.2022.2055703","volume":"11","author":"Q Yang","year":"2022","unstructured":"Yang Q, Hao J, Chi M, Wang Y, Xin B, Huang J, et al. Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism. Oncoimmunology. 2022;11(1):2055703.","journal-title":"Oncoimmunology"},{"issue":"9","key":"7887_CR186","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1182\/bloodadvances.2022008272","volume":"7","author":"S Panetti","year":"2023","unstructured":"Panetti S, McJannett N, Fultang L, Booth S, Gneo L, Scarpa U, et al. Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment. Blood Adv. 2023;7(9):1754\u201361.","journal-title":"Blood Adv"},{"issue":"4","key":"7887_CR187","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.cmet.2024.12.007","volume":"37","author":"AT Frisch","year":"2025","unstructured":"Frisch AT, Wang Y, Xie B, Yang A, Ford BR, Joshi S, et al. Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy. Cell Metab. 2025;37(4):870\u201385.e8.","journal-title":"Cell Metab"},{"issue":"1","key":"7887_CR188","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40360-021-00518-6","volume":"22","author":"B Sacks","year":"2021","unstructured":"Sacks B, Onal H, Martorana R, Sehgal A, Harvey A, Wastella C, et al. Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment. BMC Pharmacol & Toxicol. 2021;22(1):49.","journal-title":"BMC Pharmacol & Toxicol"},{"key":"7887_CR189","doi-asserted-by":"publisher","first-page":"1121565","DOI":"10.3389\/fimmu.2023.1121565","volume":"14","author":"PM Nanjireddy","year":"2023","unstructured":"Nanjireddy PM, Olejniczak SH, Buxbaum NP. Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes. Front Immunol. 2023;14:1121565.","journal-title":"Front Immunol"},{"key":"7887_CR190","doi-asserted-by":"crossref","unstructured":"Nakagawara K, Ando M, Srirat T, Mise-Omata S, Hayakawa T, Ito M, et al. NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors. J Immunother Cancer. 2024;12(8).","DOI":"10.1136\/jitc-2023-008665"},{"issue":"1","key":"7887_CR191","doi-asserted-by":"publisher","first-page":"4444","DOI":"10.1038\/s41467-024-48653-y","volume":"15","author":"MH Wu","year":"2024","unstructured":"Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, et al. Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8(+) T cell adoptive therapies in pre-clinical studies. Nat Commun. 2024;15(1):4444.","journal-title":"Nat Commun"},{"issue":"9","key":"7887_CR192","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1038\/s43018-025-00982-7","volume":"6","author":"HC Hope","year":"2025","unstructured":"Hope HC, de Sostoa J, Ginefra P, Andreatta M, Chiang YH, Ronet C, et al. Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure. Nat Cancer. 2025;6(9):1524\u201336.","journal-title":"Nat Cancer"},{"key":"7887_CR193","doi-asserted-by":"crossref","unstructured":"Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI Insight. 2023;8(20).","DOI":"10.1172\/jci.insight.163022"},{"key":"7887_CR194","doi-asserted-by":"crossref","unstructured":"Toledano Zur R, Atar O, Barliya T, Hoogi S, Abramovich I, Gottlieb E, et al. Genetically engineering glycolysis in T cells increases their antitumor function. J Immunother Cancer. 2024;12(7).","DOI":"10.1136\/jitc-2023-008434"},{"key":"7887_CR195","doi-asserted-by":"publisher","first-page":"115038","DOI":"10.1016\/j.ejmech.2022.115038","volume":"248","author":"M De Pascale","year":"2023","unstructured":"De Pascale M, Bissegger L, Tarantelli C, Beaufils F, Prescimone A, Mohamed Seid Hedad H, et al. Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor. Eur J Med Chem. 2023;248:115038.","journal-title":"Eur J Med Chem"},{"key":"7887_CR196","doi-asserted-by":"publisher","first-page":"114498","DOI":"10.1016\/j.ejmech.2022.114498","volume":"238","author":"P Oleksak","year":"2022","unstructured":"Oleksak P, Nepovimova E, Chrienova Z, Musilek K, Patocka J, Kuca K. Contemporary mTOR inhibitor scaffolds to diseases breakdown: a patent review (2015-2021). Eur J Med Chem. 2022;238:114498.","journal-title":"Eur J Med Chem"},{"key":"7887_CR197","doi-asserted-by":"crossref","unstructured":"Jhanwar-Uniyal M, Zeller SL, Spirollari E, Das M, Hanft SJ, Gandhi CD. Discrete mechanistic target of Rapamycin signaling pathways, stem cells, and therapeutic targets. Cells. 2024;13(5).","DOI":"10.3390\/cells13050409"},{"issue":"4","key":"7887_CR198","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1158\/2326-6066.CIR-19-0702","volume":"8","author":"R Lin","year":"2020","unstructured":"Lin R, Zhang H, Yuan Y, He Q, Zhou J, Li S, et al. Fatty acid oxidation controls CD8(+) tissue-resident memory T-cell survival in gastric adenocarcinoma. Cancer Immunol Res. 2020;8(4):479\u201392.","journal-title":"Cancer Immunol Res"},{"issue":"5","key":"7887_CR199","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.cmet.2024.02.009","volume":"36","author":"EG Hunt","year":"2024","unstructured":"Hunt EG, Hurst KE, Riesenberg BP, Kennedy AS, Gandy EJ, Andrews AM, et al. Acetyl-CoA carboxylase obstructs CD8(+) T cell lipid utilization in the tumor microenvironment. Cell Metab. 2024;36(5):969\u201383.e10.","journal-title":"Cell Metab"},{"issue":"5","key":"7887_CR200","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.immuni.2021.02.020","volume":"54","author":"M Tello-Lafoz","year":"2021","unstructured":"Tello-Lafoz M, Srpan K, Sanchez EE, Hu J, Remsik J, Romin Y, et al. Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity. 2021;54(5):1037\u201354.e7.","journal-title":"Immunity"},{"issue":"2","key":"7887_CR201","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1158\/0008-5472.CAN-20-2569","volume":"81","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zhang T, Zhang H, Li J, Zhou N, Fiskesund R, et al. Cell softness prevents cytolytic T-cell killing of tumor-repopulating cells. Cancer Res. 2021;81(2):476\u201388.","journal-title":"Cancer Res"},{"issue":"12","key":"7887_CR202","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/s41551-021-00826-6","volume":"5","author":"K Lei","year":"2021","unstructured":"Lei K, Kurum A, Kaynak M, Bonati L, Han Y, Cencen V, et al. Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy. Nat Biomed Eng. 2021;5(12):1411\u201325.","journal-title":"Nat Biomed Eng"},{"key":"7887_CR203","doi-asserted-by":"crossref","unstructured":"Alahdal M, Elkord E. Non-coding RNAs in cancer immunotherapy: predictive biomarkers and targets, clinical and translational medicine. 2023;13(9):e 1425.","DOI":"10.1002\/ctm2.1425"},{"issue":"8","key":"7887_CR204","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1158\/2326-6066.CIR-23-0339","volume":"12","author":"M Meng","year":"2024","unstructured":"Meng M, Zhong Z, Song L, Zhang Z, Yin X, Xie X, et al. Deng, mTOR signaling promotes rapid m6A mRNA methylation to regulate NK-Cell activation and effector functions. Cancer Immunol Res. 2024;12(8):1039\u201357.","journal-title":"Cancer Immunol Res"},{"key":"7887_CR205","doi-asserted-by":"publisher","first-page":"619195","DOI":"10.3389\/fimmu.2021.619195","volume":"12","author":"Z Wang","year":"2021","unstructured":"Wang Z, Guan D, Huo J, Biswas SK, Huang Y, Yang Y, et al. IL-10 enhances human Natural killer cell effector functions via metabolic reprogramming regulated by mTORC1 signaling. Front Immunol. 2021;12:619195.","journal-title":"Front Immunol"},{"issue":"9","key":"7887_CR206","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1002\/cam4.1713","volume":"7","author":"Y Long","year":"2018","unstructured":"Long Y, Gao Z, Hu X, Xiang F, Wu Z, Zhang J, et al. Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma. Cancer Med. 2018;7(9):4690\u2013700.","journal-title":"Cancer Med"},{"key":"7887_CR207","doi-asserted-by":"crossref","unstructured":"Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, et al. Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. EMBO Mol Med. 2019;11(11):e10698.","DOI":"10.15252\/emmm.201910698"},{"issue":"5","key":"7887_CR208","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1158\/2326-6066.CIR-19-0261","volume":"8","author":"L Wu","year":"2020","unstructured":"Wu L, Zhang X, Zheng L, Zhao H, Yan G, Zhang Q, et al. RIPK3 orchestrates fatty acid metabolism in tumor-associated macrophages and hepatocarcinogenesis. Cancer Immunol Res. 2020;8(5):710\u201321.","journal-title":"Cancer Immunol Res"},{"key":"7887_CR209","doi-asserted-by":"crossref","unstructured":"Luo J, Guo M, Huang M, Liu Y, Qian Y, Liu Q, et al. Neoleukin-2\/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc\/NRF1 activation. Signal Transduct Target Ther. 2025;10(1):78.","DOI":"10.1038\/s41392-025-02158-2"},{"key":"7887_CR210","doi-asserted-by":"publisher","first-page":"1600411","DOI":"10.3389\/fimmu.2025.1600411","volume":"16","author":"C Hu","year":"2025","unstructured":"Hu C, Lai W, Tian B, Xu X, Xie S, Zhong W, et al. Application and prospects of genetic engineering in CAR-NK cell therapy. Front Immunol. 2025;16:1600411.","journal-title":"Front Immunol"},{"key":"7887_CR211","doi-asserted-by":"publisher","first-page":"783305","DOI":"10.3389\/fimmu.2021.783305","volume":"12","author":"C Sloas","year":"2021","unstructured":"Sloas C, Gill S, Klichinsky M. Engineered CAR-Macrophages as adoptive Immunotherapies for solid tumors. Front Immunol. 2021;12:783305.","journal-title":"Front Immunol"},{"key":"7887_CR212","doi-asserted-by":"crossref","unstructured":"Wu J, Cheng J, Zhu L, Gao Q, Lin H, Zeng Y, et al. CD5 ablation enhances persistence and antitumor potency of engineered T cells by mitigating exhaustion and promoting cytotoxicity. J Immunother Cancer. 2025;13(11).","DOI":"10.1136\/jitc-2025-012243"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-07887-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07887-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07887-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:23:00Z","timestamp":1775571780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-07887-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":212,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7887"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-07887-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"12 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"476"}}