{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:08:17Z","timestamp":1794474497993,"version":"4.9.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-07953-1","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:57:24Z","timestamp":1773910644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The microbiome of host saliva, gastric fluid, and gastric mucosa as accurate diagnostic tools for gastric cancer detection"],"prefix":"10.1186","volume":"24","author":[{"given":"Changzhen","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruotang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianji","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daojun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"issue":"3","key":"7953_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"7953_CR2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","volume":"135","author":"C Xia","year":"2022","unstructured":"Xia C, Dong X, Li H, Cao M, Sun D, He S, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl). 2022;135(5):584\u201390.","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"7953_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.gtc.2013.01.002","volume":"42","author":"P Correa","year":"2013","unstructured":"Correa P. Gastric cancer: overview. Gastroenterol Clin N Am. 2013;42(2):211\u201317.","journal-title":"Gastroenterol Clin N Am"},{"issue":"9","key":"7953_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41571-025-01049-3","volume":"22","author":"JB Xavier","year":"2025","unstructured":"Xavier JB. Ecological management of the microbiota in patients with cancer. Nat Rev Clin Oncol. 2025;22(9):627\u201339.","journal-title":"Nat Rev Clin Oncol"},{"issue":"10","key":"7953_CR5","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1158\/0008-5472.CAN-24-2580","volume":"85","author":"T Zhang","year":"2025","unstructured":"Zhang T, Li Y, Zhai E, Zhao R, Qian Y, Huang Z, et al. Intratumoral Fusobacterium nucleatum recruits tumor-associated neutrophils to promote gastric cancer progression and immune evasion. Cancer Res. 2025;85(10):1819\u201341.","journal-title":"Cancer Res"},{"issue":"4","key":"7953_CR6","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2024.01.004","volume":"187","author":"K Fu","year":"2024","unstructured":"Fu K, Cheung AHK, Wong CC, Liu W, Zhou Y, Wang F, et al. Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. Cell. 2024;187(4):882\u201396.e17.","journal-title":"Cell"},{"issue":"11","key":"7953_CR7","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1158\/2159-8290.CD-24-0835","volume":"14","author":"CC Wong","year":"2024","unstructured":"Wong CC, Yu J. Redefining the gastric Microbes in promoting gastric tumorigenesis: the rise of the non-H. pylori microbiome. Cancer Discov. 2024;14(11):2051\u201354.","journal-title":"Cancer Discov"},{"key":"7953_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40168-023-01730-8","volume":"12","author":"J Chen","year":"2024","unstructured":"Chen J, Sun Y, Li J, et al. In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study. Microbiome. 2024;12:6.","journal-title":"Microbiome"},{"issue":"1","key":"7953_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40168-023-01730-8","volume":"12","author":"J Chen","year":"2024","unstructured":"Chen J, Sun Y, Li J, Lyu M, Yuan L, Sun J, et al. In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study. Microbiome. 2024;12(1):6.","journal-title":"Microbiome"},{"issue":"9","key":"7953_CR10","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.14309\/ajg.0000000000003279","volume":"120","author":"F Sadeghi","year":"2024","unstructured":"Sadeghi F, Sohrabi A, Zagai U, Andreasson A, Vieth M, Talley NJ, et al. Oral microbiome dysbiosis is associated with precancerous lesions and disorders of upper Gastrointestinal tract: a population-based study. Am J Gastroenterol. 2024;120(9):2173\u201385.","journal-title":"Am. J. Gastroenterol"},{"issue":"Pt 3","key":"7953_CR11","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.semcancer.2021.11.002","volume":"86","author":"M Stasiewicz","year":"2022","unstructured":"Stasiewicz M, Karpi\u0144ski TM. The oral microbiota and its role in carcinogenesis. Semin Cancer Biol. 2022;86(Pt 3):633\u201342.","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"7953_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.4103\/ijdr.IJDR_802_20","volume":"34","author":"AA Ras","year":"2023","unstructured":"Ras AA, Kheir El Din NH, Talaat AM, Hussein RR, Khalil E. Mucocutaneous changes in end-stage renal disease under regular hemodialysis - a cross-sectional study. Indian J Dent Res. 2023;34(2):130\u201335.","journal-title":"Indian J Dent Res"},{"issue":"10","key":"7953_CR13","doi-asserted-by":"publisher","first-page":"300060524128929","DOI":"10.1177\/03000605241289292","volume":"52","author":"D Ghalwash","year":"2024","unstructured":"Ghalwash D, El-Gawish A, Ammar A, Hamdy A, Ghanem R, Ghanem M, et al. Epidemiology of Sjogren\u2019s syndrome in a sample of the Egyptian population: a cross-sectional study. J Int Med Res. 2024;52(10):3000605241289292.","journal-title":"J Int Med Res"},{"issue":"2","key":"7953_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1574-6976.2010.00251.x","volume":"35","author":"D Knights","year":"2011","unstructured":"Knights D, Costello EK, Knight R. Supervised classification of human microbiota. FEMS Microbiol Rev. 2011;35(2):343\u201359.","journal-title":"FEMS Microbiol Rev"},{"key":"7953_CR15","doi-asserted-by":"crossref","unstructured":"Zhou T, Zhao F. AI-empowered human microbiome research. Gut. 2025.","DOI":"10.1136\/gutjnl-2025-335946"},{"key":"7953_CR16","doi-asserted-by":"publisher","first-page":"102884","DOI":"10.1016\/j.copbio.2022.102884","volume":"79","author":"F Salim","year":"2023","unstructured":"Salim F, Mizutani S, Zolfo M, Yamada T. Recent advances of machine learning applications in human gut microbiota study: from observational analysis toward causal inference and clinical intervention. Curr Opin Biotechnol. 2023;79:102884.","journal-title":"Curr Opin Biotechnol"},{"issue":"1","key":"7953_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s43705-022-00182-9","volume":"2","author":"Hern\u00e1ndez Medina","year":"2022","unstructured":"Hern\u00e1ndez Medina, Kutuzova S, Nielsen KN, Johansen J, Hansen LH, Nielsen M, et al. Machine learning and deep learning applications in microbiome research. ISME Commun. 2022;2(1):98.","journal-title":"ISME Commun"},{"issue":"2","key":"7953_CR18","first-page":"93","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin. 2017;67(2):93\u201399.","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"7953_CR19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/1751-2980.12705","volume":"20","author":"YC Shi","year":"2019","unstructured":"Shi YC, Wang ZK, Yang YS. Consensus on standard biobanking of gut microbiota. J Dig Dis. 2019;20(3):114\u201321.","journal-title":"J Dig Dis"},{"issue":"8","key":"7953_CR20","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019;37(8):852\u201357.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"7953_CR21","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/brv.12252","volume":"92","author":"CM Tucker","year":"2017","unstructured":"Tucker CM, Cadotte MW, Carvalho SB, Davies TJ, Ferrier S, Fritz SA, et al. A guide to phylogenetic metrics for conservation, community ecology and macroecology. Biol Rev Camb Philos Soc. 2017;92(2):698\u2013715.","journal-title":"Biol Rev Camb Philos Soc"},{"key":"7953_CR22","doi-asserted-by":"crossref","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12(6):R60.","DOI":"10.1186\/gb-2011-12-6-r60"},{"issue":"6","key":"7953_CR23","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1136\/gutjnl-2022-327156","volume":"72","author":"C Kong","year":"2023","unstructured":"Kong C, Liang L, Liu G, Du L, Yang Y, Liu J, et al. Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer. Gut. 2023;72(6):1129\u201342.","journal-title":"Gut"},{"issue":"6","key":"7953_CR24","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1136\/gutjnl-2017-315084","volume":"68","author":"Z Ren","year":"2019","unstructured":"Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, et al. Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma. Gut. 2019;68(6):1014\u201323.","journal-title":"Gut"},{"issue":"7","key":"7953_CR25","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1053\/j.gastro.2022.02.015","volume":"162","author":"CB Zhou","year":"2022","unstructured":"Zhou CB, Pan SY, Jin P, Deng JW, Xue JH, Ma XY, et al. Fecal signatures of Streptococcus anginosus and Streptococcus constellatus for noninvasive screening and early warning of gastric cancer. Gastroenterology. 2022;162(7):1933\u201347.e18.","journal-title":"Gastroenterology"},{"issue":"1","key":"7953_CR26","doi-asserted-by":"publisher","first-page":"2375483","DOI":"10.1080\/19490976.2024.2375483","volume":"16","author":"A Villani","year":"2024","unstructured":"Villani A, Fontana A, Panebianco C, Ferro C, Copetti M, Pavlovic R, et al. A powerful machine learning approach to identify interactions of differentially abundant gut microbial subsets in patients with metastatic and non-metastatic pancreatic cancer. Gut Microbes. 2024;16(1):2375483.","journal-title":"Gut Microbes"},{"key":"7953_CR27","doi-asserted-by":"publisher","first-page":"217456","DOI":"10.1016\/j.canlet.2025.217456","volume":"612","author":"P Li","year":"2025","unstructured":"Li P, Zhang H, Chen L, Gao X, Hu Y, Xu Q, et al. Oral and fecal microbiota as accurate non-invasive tools for detection of pancreatic cancer in the Chinese population. Cancer Lett. 2025;612:217456.","journal-title":"Cancer Lett"},{"issue":"1","key":"7953_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12967-024-05989-9","volume":"23","author":"S Oh","year":"2025","unstructured":"Oh S, Kim J, Shin CM, Lee HJ, Lee HS, Park KU. Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case-control study. J Transl Med. 2025;23(1):20.","journal-title":"J Transl Med"},{"issue":"6","key":"7953_CR29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","volume":"67","author":"OO Coker","year":"2018","unstructured":"Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018;67(6):1024\u201332.","journal-title":"Gut"},{"issue":"1","key":"7953_CR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40168-023-01534-w","volume":"11","author":"B Oosterlinck","year":"2023","unstructured":"Oosterlinck B, Ceuleers H, Arras W, De Man JG, Geboes K, De Schepper H, et al. Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer. Microbiome. 2023;11(1):86.","journal-title":"Microbiome"},{"issue":"1","key":"7953_CR31","doi-asserted-by":"publisher","first-page":"2186677","DOI":"10.1080\/19490976.2023.2186677","volume":"15","author":"A Mannion","year":"2023","unstructured":"Mannion A, Sheh A, Shen Z, Dzink-Fox J, Piazuelo MB, Wilson KT, et al. Shotgun metagenomics of gastric biopsies reveals compositional and functional microbiome shifts in high- and low-gastric-cancer-risk populations from Colombia, South America. Gut Microbes. 2023;15(1):2186677.","journal-title":"Gut Microbes"},{"issue":"8","key":"7953_CR32","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1136\/gutjnl-2019-319188","volume":"69","author":"PP Erawijantari","year":"2020","unstructured":"Erawijantari PP, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, et al. Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles. Gut. 2020;69(8):1404\u201315.","journal-title":"Gut"},{"key":"7953_CR33","doi-asserted-by":"crossref","unstructured":"Chen Y, Lei L, Xia M, Cheng R, Cai H, Hu T. The association between oral microbiome and gastric precancerous lesions. mSystems. 2025;10(1):e0132224.","DOI":"10.1128\/msystems.01322-24"},{"issue":"1","key":"7953_CR34","doi-asserted-by":"publisher","first-page":"2554196","DOI":"10.1080\/19490976.2025.2554196","volume":"17","author":"R Zhou","year":"2025","unstructured":"Zhou R, Ng SK, Sung JJY, Wong SH, Goh WWB. Detecting and mitigating doppelg\u00e4nger bias in microbiome data: impacts on machine learning and disease classification. Gut Microbes. 2025;17(1):2554196.","journal-title":"Gut Microbes"},{"key":"7953_CR35","doi-asserted-by":"publisher","first-page":"640309","DOI":"10.3389\/fcimb.2021.640309","volume":"11","author":"K Huang","year":"2021","unstructured":"Huang K, Gao X, Wu L, Yan B, Wang Z, Zhang X, et al. Salivary microbiota for gastric cancer prediction: an exploratory study. Front Cell Infect Microbiol. 2021;11:640309.","journal-title":"Front Cell Infect Microbiol"},{"key":"7953_CR36","doi-asserted-by":"publisher","first-page":"830684","DOI":"10.3389\/fcimb.2022.830684","volume":"12","author":"C Zhang","year":"2022","unstructured":"Zhang C, Hu A, Li J, Zhang F, Zhong P, Li Y, et al. Combined non-invasive prediction and New biomarkers of oral and fecal microbiota in patients with gastric and colorectal cancer. Front Cell Infect Microbiol. 2022;12:830684.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"7953_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41522-024-00623-4","volume":"11","author":"M Xia","year":"2025","unstructured":"Xia M, Lei L, Zhao L, Xu W, Zhang H, Li M, et al. The dynamic oral-gastric microbial axis connects oral and gastric health: current evidence and disputes. NPJ Biofilms Microbiomes. 2025;11(1):1.","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"9","key":"7953_CR38","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1136\/gutjnl-2019-319826","volume":"69","author":"JJY Sung","year":"2020","unstructured":"Sung JJY, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, et al. Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication. Gut. 2020;69(9):1572\u201380.","journal-title":"Gut"},{"issue":"21","key":"7953_CR39","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.7150\/jca.25280","volume":"9","author":"J Wu","year":"2018","unstructured":"Wu J, Xu S, Xiang C, Cao Q, Li Q, Huang J, et al. Tongue coating microbiota community and risk effect on gastric cancer. J Cancer. 2018;9(21):4039\u201348.","journal-title":"J Cancer"},{"issue":"22","key":"7953_CR40","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1002\/cncr.32403","volume":"125","author":"D Shao","year":"2019","unstructured":"Shao D, Vogtmann E, Liu A, Qin J, Chen W, Abnet CC, et al. Microbial characterization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-risk region of China. Cancer. 2019;125(22):3993\u20134002.","journal-title":"Cancer"},{"key":"7953_CR41","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3389\/fmicb.2020.00997","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z, Gao X, Zeng R, Wu Q, Sun H, Wu W, et al. Changes of the gastric mucosal microbiome associated with histological stages of gastric carcinogenesis. Front Microbiol. 2020;11:997.","journal-title":"Front Microbiol"},{"key":"7953_CR42","doi-asserted-by":"crossref","unstructured":"Seyyedsalehi MS, Mohebbi E, Tourang F, Sasanfar B, Boffetta P, Zendehdel K. Association of dietary nitrate, nitrite, and N-Nitroso compounds intake and Gastrointestinal cancers: a systematic review and meta-analysis. Toxics. 2023;11(2).","DOI":"10.3390\/toxics11020190"},{"issue":"7","key":"7953_CR43","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1136\/gutjnl-2021-324755","volume":"71","author":"E Kartal","year":"2022","unstructured":"Kartal E, Schmidt TSB, Molina-Montes E, Rodr\u00edguez-Perales S, Wirbel J, Maistrenko OM, et al. A faecal microbiota signature with high specificity for pancreatic cancer. Gut. 2022;71(7):1359\u201372.","journal-title":"Gut"},{"issue":"1","key":"7953_CR44","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1038\/s41598-021-82465-0","volume":"11","author":"MA Osman","year":"2021","unstructured":"Osman MA, Neoh HM, Ab Mutalib NS, Chin SF, Mazlan L, Raja Ali RA, et al. Parvimonas micra, Peptostreptococcus stomatis, Fusobacterium nucleatum and Akkermansia muciniphila as a four-bacteria biomarker panel of colorectal cancer. Sci Rep. 2021;11(1):2925.","journal-title":"Sci Rep"},{"issue":"1","key":"7953_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s44342-024-00001-8","volume":"22","author":"AR Nath","year":"2024","unstructured":"Nath AR, Natarajan J. Gut metagenomic analysis of gastric cancer patients reveals Akkermansia, Gammaproteobacteria, and Veillonella microbiota as potential non-invasive biomarkers. Genomics Inf. 2024;22(1):1.","journal-title":"Genomics Inf"},{"key":"7953_CR46","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3389\/fmicb.2019.01261","volume":"10","author":"XH Chen","year":"2019","unstructured":"Chen XH, Wang A, Chu AN, Gong YH, Yuan Y. Mucosa-associated microbiota in gastric cancer Tissues compared with non-cancer Tissues. Front Microbiol. 2019;10:1261.","journal-title":"Front Microbiol"},{"key":"7953_CR47","doi-asserted-by":"publisher","first-page":"1435334","DOI":"10.3389\/fimmu.2024.1435334","volume":"15","author":"C Qian","year":"2024","unstructured":"Qian C, Hui J, Peng Z, et al. Mucosal microbiota characterization in gastric cancer identifies immune-activated-related transcripts relevant gastric microbiome signatures. Front Immunol. 2024;15:1435334.","journal-title":"Front Immunol"},{"issue":"1","key":"7953_CR48","doi-asserted-by":"publisher","first-page":"2432222","DOI":"10.1080\/20565623.2024.2432222","volume":"11","author":"D Ghalwash","year":"2025","unstructured":"Ghalwash D, Ammar A, Abou-Bakr A, Diab AH, El-Gawish A. Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population. Future Sci OA. 2025;11(1):2432222.","journal-title":"Future Sci OA"},{"issue":"2","key":"7953_CR49","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1053\/j.gastro.2020.11.041","volume":"160","author":"V Matson","year":"2021","unstructured":"Matson V, Chervin CS, Gajewski TF. Cancer and the microbiome-influence of the commensal microbiota on cancer, immune responses, and immunotherapy. Gastroenterology. 2021;160(2):600\u201313.","journal-title":"Gastroenterology"},{"issue":"5","key":"7953_CR50","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s42255-025-01287-w","volume":"7","author":"A Nobels","year":"2025","unstructured":"Nobels A, van Marcke C, Jordan BF, Van Hul M, Cani PD. The gut microbiome and cancer: from tumorigenesis to therapy. Nat Metab. 2025;7(5):895\u2013917.","journal-title":"Nat Metab"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-07953-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07953-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-07953-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:02:31Z","timestamp":1784098951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-07953-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7953"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-07953-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Written informed consent for the use of patient specimens was obtained from each participant. The study protocols were approved by the Research Ethics Committee of Shanghai General Hospital and Jinhua Hospital of Zhejiang University.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"912"}}