{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:38:06Z","timestamp":1788777486457,"version":"build-2803163510"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["82260431"],"award-info":[{"award-number":["82260431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guizhou Province Science and Technology Support Plan","award":["Guizhou Science and Technology Cooperation Support [2023] General 196"],"award-info":[{"award-number":["Guizhou Science and Technology Cooperation Support [2023] General 196"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08017-0","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:06:35Z","timestamp":1773756395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting the PINK1\/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia"],"prefix":"10.1186","volume":"24","author":[{"given":"Mengyan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"8017_CR1","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s00198-017-4151-8]","volume":"28","author":"HP Hirschfeld","year":"2017","unstructured":"Hirschfeld HP, Kinsella R, Duque G. Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos Int. 2017;28:2781\u201390. PMID: 28733716IF: 5.4 Q1 B2.","journal-title":"Osteoporos Int"},{"key":"8017_CR2","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.3390\/ijms23105591]","volume":"23","author":"A Polito","year":"2022","unstructured":"Polito A, Barnaba L, Ciarapica D, Azzini E. Osteosarcopenia: a narrative review on clinical studies. Int J Mol Sci. 2022;23:5591. PMID: 35628399IF: 4.9 Q1 B3.","journal-title":"Int J Mol Sci"},{"key":"8017_CR3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3390\/cells10020237","volume":"10","author":"G Li","year":"2021","unstructured":"Li G, Zhang L, Ning K, Yang B, Acosta FM, Shang P, Jiang JX, Xu H. Osteocytic Connexin43 channels regulate bone-muscle crosstalk. Cells. 2021;10:237. PMID: 33530465IF: 5.2 Q2 B2.","journal-title":"Cells"},{"key":"8017_CR4","doi-asserted-by":"publisher","first-page":"1349253","DOI":"10.3389\/fphys.2024.1349253]","volume":"15","author":"H Sui","year":"2024","unstructured":"Sui H, Dou J, Shi B, Cheng X. The reciprocity of skeletal muscle and bone: an evolving view from mechanical coupling, secretory crosstalk to stem cell exchange. Front Physiol. 2024;15:1349253. PMID: 38505709IF: 3.4 Q1 B3.","journal-title":"Front Physiol"},{"key":"8017_CR5","doi-asserted-by":"publisher","first-page":"glae186","DOI":"10.1093\/gerona\/glae186]","volume":"79","author":"J Zhou","year":"2024","unstructured":"Zhou J, Tang R, Wang X, Ma H, Li X, Heianza Y, Qi L. Frailty status, sedentary behaviors, and risk of incident bone fractures. J Gerontol Biol Sci Med Sci. 2024;79:glae186. PMID: 39086331IF: 3.8 Q1 B2.","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"8017_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/bs.acc.2019.07.010]","volume":"94","author":"M Gomarasca","year":"2020","unstructured":"Gomarasca M, Banfi G, Lombardi G, Myokines. The endocrine coupling of skeletal muscle and bone. Adv Clin Chem. 2020;94:155\u2013218. PMID: 31952571IF: NA NA NA.","journal-title":"Adv Clin Chem"},{"key":"8017_CR7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s11914-020-00599-y]","volume":"18","author":"B Kirk","year":"2020","unstructured":"Kirk B, Feehan J, Lombardi G, Duque G. Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines. Curr Osteoporos Rep. 2020;18:388\u2013400. PMID: 32529456IF: 5.3 Q1 B2.","journal-title":"Curr Osteoporos Rep"},{"key":"8017_CR8","doi-asserted-by":"publisher","first-page":"10116","DOI":"10.3390\/ijms251810116","volume":"25","author":"C Zhao","year":"2024","unstructured":"Zhao C, Wu Y, Zhu S, Liu H, Xu S. Irisin protects musculoskeletal homeostasis via a mitochondrial quality control mechanism. Int J Mol Sci. 2024;25:10116. PMID: 39337601IF: 4.9 Q1 B3.","journal-title":"Int J Mol Sci"},{"key":"8017_CR9","doi-asserted-by":"publisher","first-page":"101679","DOI":"10.1016\/j.jbc.2022.101679]","volume":"298","author":"X He","year":"2022","unstructured":"He X, Hua Y, Li Q, Zhu W, Pan Y, Yang Y, Li X, Wu M, Wang J, Gan X. FNDC5\/irisin facilitates muscle\u2013adipose\u2013bone connectivity through ubiquitination-dependent activation of runt-related transcriptional factors RUNX1\/2. J Biol Chem. 2022;298:101679. PMID: 35124008IF: 3.9 Q2 B2..","journal-title":"J Biol Chem"},{"key":"8017_CR10","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3390\/biomedicines9060701]","volume":"9","author":"H Li","year":"2021","unstructured":"Li H, Qin S, Liang Q, Xi Y, Bo W, Cai M, Tian Z. Exercise training enhances myocardial mitophagy and improves cardiac function via Irisin\/FNDC5-PINK1\/Parkin pathway in MI mice. Biomedicines. 2021;9:701. PMID: 34205641IF: 3.9 Q1 B3.","journal-title":"Biomedicines"},{"key":"8017_CR11","doi-asserted-by":"publisher","first-page":"14006","DOI":"10.3390\/ijms232214006]","volume":"23","author":"A Picca","year":"2022","unstructured":"Picca A, Calvani R, Coelho-J\u00fanior HJ, Marini F, Landi F, Marzetti E. Circulating inflammatory, mitochondrial dysfunction, and senescence-related markers in older adults with physical frailty and sarcopenia: a BIOSPHERE exploratory study. Int J Mol Sci. 2022;23:14006. PMID: 36430485IF: 4.9 Q1 B3.","journal-title":"Int J Mol Sci"},{"key":"8017_CR12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3389\/fendo.2019.00255]","volume":"10","author":"EA Greco","year":"2019","unstructured":"Greco EA, Pietschmann P, Migliaccio S. Osteoporosis and sarcopenia increase frailty syndrome in the elderly. Front Endocrinol (Lausanne). 2019;10:255. PMID: 31068903IF: 4.6 Q1 B3.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"8017_CR13","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1038\/s41598-017-02557-8]","volume":"7","author":"G Colaianni","year":"2017","unstructured":"Colaianni G, Mongelli T, Cuscito C, Pignataro P, Lippo L, Spiro G, Notarnicola A, Severi I, Passeri G, Mori G, Brunetti G, Moretti B, Tarantino U, Colucci SC, Reseland JE, Vettor R, Cinti S, Grano M. Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice. Sci Rep. 2017;7:2811. PMID: 28588307IF: 3.9 Q1 B3.","journal-title":"Sci Rep"},{"key":"8017_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.mito.2023.07.003]","volume":"72","author":"GB Kubat","year":"2023","unstructured":"Kubat GB, Bouhamida E, Ulger O, Turkel I, Pedriali G, Ramaccini D, Ekinci O, Ozerklig B, Atalay O, Patergnani S, Nur Sahin B, Morciano G, Tuncer M, Tremoli E, Pinton P. Mitochondrial dysfunction and skeletal muscle atrophy: causes, mechanisms, and treatment strategies. Mitochondrion. 2023;72:33\u201358. PMID: 37451353IF: 4.5 Q1 B3.","journal-title":"Mitochondrion"},{"key":"8017_CR15","doi-asserted-by":"publisher","first-page":"e96553","DOI":"10.15252\/embj.201796553]","volume":"37","author":"A Rodr\u00edguez-Nuevo","year":"2018","unstructured":"Rodr\u00edguez-Nuevo A, D\u00edaz-Ramos A, Noguera E, D\u00edaz-S\u00e1ez F, Duran X, Mu\u00f1oz JP, Romero M, Plana N, Sebasti\u00e1n D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, Gonz\u00e1lez J, Borr\u00e0s M, Liesa M, Palac\u00edn M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018;37:e96553. PMID: 29632021IF: 8.3 Q1 B1.","journal-title":"EMBO J"},{"key":"8017_CR16","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1113\/JP275604","volume":"596","author":"G Gouspillou","year":"2018","unstructured":"Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves-Smith FM, Sgarioto N, Hepple RT, Burelle Y, Hussain SNA. Protective role of Parkin in skeletal muscle contractile and mitochondrial function. J Physiol. 2018;596:2565\u201379. PMID: 29682760IF: 4.4 Q1 B2.","journal-title":"J Physiol"},{"key":"8017_CR17","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.phrs.2018.02.020]","volume":"130","author":"Y Pan","year":"2018","unstructured":"Pan Y, Kong L-D. High fructose diet-induced metabolic syndrome: pathophysiological mechanism and treatment by traditional Chinese medicine. Pharmacol Res. 2018;130:438\u201350. PMID: 29471102IF: 10.5 Q1 B2.","journal-title":"Pharmacol Res"},{"key":"8017_CR18","doi-asserted-by":"publisher","first-page":"e924699","DOI":"10.12659\/MSM.924699","volume":"26","author":"Z Long","year":"2020","unstructured":"Long Z, Wu J, Xiang W, Zeng Z, Yu G, Li J. Exploring the mechanism of icariin in osteoporosis based on a network pharmacology strategy. Med Sci Monit. 2020;26:e924699. PMID: 33230092IF: 2.1 Q3 B4.","journal-title":"Med Sci Monit"},{"key":"8017_CR19","doi-asserted-by":"publisher","first-page":"1351376","DOI":"10.3389\/fmed.2024.1351376]","volume":"11","author":"A Sun","year":"2024","unstructured":"Sun A, Liu S, Yin F, Li Z, Liu Z. Circulating inflammatory cytokines and sarcopenia-related traits: a mendelian randomization analysis. Front Med (Lausanne). 2024;11:1351376. PMID: 39193020IF: 3.0 Q1 B3.","journal-title":"Front Med (Lausanne)"},{"key":"8017_CR20","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1681\/ASN.2016010098","volume":"27","author":"P Sekula","year":"2016","unstructured":"Sekula P, Del Greco MF, Pattaro C, K\u00f6ttgen A. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016;27:3253\u201365. PMID: 27486138IF: 9.4 Q1 B1.","journal-title":"J Am Soc Nephrol"},{"key":"8017_CR21","doi-asserted-by":"publisher","first-page":"e70540","DOI":"10.1002\/fsn3.70540]","volume":"13","author":"M Sun","year":"2025","unstructured":"Sun M, Wu T, Wang R, Ma Y, Han Y, Hou Y, Zhang Z. Four dairy products mitigates sarcopenia in mice by modulating muscle inflammation, autophagy, and protein degradation. Food Sci Nutr. 2025;13:e70540. PMID: 40661801IF: 3.8 Q2 B2.","journal-title":"Food Sci Nutr"},{"key":"8017_CR22","doi-asserted-by":"publisher","first-page":"1228937","DOI":"10.3389\/fendo.2023.1228937]","volume":"14","author":"S Weiwei, Wang","year":"2023","unstructured":"Weiwei, Wang S, Hou D, Zhan L. Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review. Front Endocrinol. 2023;14:1228937. PMID: 37964970IF: 4.6 Q1 B3.","journal-title":"Front Endocrinol"},{"key":"8017_CR23","doi-asserted-by":"publisher","unstructured":"Angeloni C, Barbalace MC, Hrelia S. Icariin and its metabolites as potential protective phytochemicals against Alzheimer\u2019s disease. Front Pharmacol. 2019;10. https:\/\/doi.org\/10.3389\/fphar.2019.00271.","DOI":"10.3389\/fphar.2019.00271"},{"key":"8017_CR24","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1093\/jpp\/rgae100]","volume":"76","author":"B Dik","year":"2024","unstructured":"Dik B, Parlak TM, Ates MB, Tufan O. Exploring the combined therapeutic efficacy of bexarotene and icariin in type 2 diabetic rats. J Pharm Pharmacol. 2024;76:1474\u201381. PMID: 39024515IF: 3.2 Q2 B4.","journal-title":"J Pharm Pharmacol"},{"key":"8017_CR25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature14893]","volume":"524","author":"M Lazarou","year":"2015","unstructured":"Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 2015;524:309\u201314. PMID: 26266977IF: 48.5 Q1 B1.","journal-title":"Nature"},{"key":"8017_CR26","doi-asserted-by":"crossref","unstructured":"Bock FJ, Tait SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020;21. PMID: 31636403IF: 90.2 Q1 B1.","DOI":"10.1038\/s41580-019-0173-8"},{"key":"8017_CR27","doi-asserted-by":"publisher","unstructured":"Lagunas-Rangel FA. Sirtuins in mitophagy: key gatekeepers of mitochondrial quality. Mol Cell Biochem (e-pub ahead of print) 2025 July 24. https:\/\/doi.org\/10.1007\/s11010-025-05358-0.","DOI":"10.1007\/s11010-025-05358-0"},{"key":"8017_CR28","doi-asserted-by":"crossref","unstructured":"Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM, Bohr VA. Protecting the mitochondrial powerhouse. Trends Cell Biol. 2015;25. PMID: 25499735IF: 18.1 Q1 B1.","DOI":"10.1016\/j.tcb.2014.11.002"},{"key":"8017_CR29","doi-asserted-by":"crossref","unstructured":"Wang L, Zhou X, Lu T. Role of mitochondria in physiological activities, diseases, and therapy. Mol Biomed. 2025;6. PMID: 40536597IF: 10.1 Q1 B2.","DOI":"10.1186\/s43556-025-00284-5"},{"key":"8017_CR30","unstructured":"Picard M, Shirihai OS. Mitochondrial signal transduction. Cell Metabolism. 2022;34. PMID: 36323233IF: 30.9 Q1 B1."},{"key":"8017_CR31","doi-asserted-by":"crossref","unstructured":"Li W, He P, Huang Y, Li YF, Lu J, Li M, Kurihara H, Luo Z, Meng T, Onishi M, Ma C, Jiang L, Hu Y, Gong Q, Zhu D, Xu Y, Liu R, Liu L, Yi C, Zhu Y, Ma N, Okamoto K, Xie Z, Liu J, He RR, Feng D. Selective autophagy of intracellular organelles: recent research advances. Theranostics. 2021; 11. PMID: 33391472IF: 13.3 Q1 B1.","DOI":"10.7150\/thno.49860"},{"key":"8017_CR32","doi-asserted-by":"crossref","unstructured":"Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K. Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021;40. PMID: 33438778IF: 8.3 Q1 B1.","DOI":"10.15252\/embj.2020104705"},{"key":"8017_CR33","doi-asserted-by":"crossref","unstructured":"Li WJ, Yang L, Han WF, Gao LJ, Xu ZG, Wang HL, Yang C, Liu HF. p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell Mol Biol Lett. 2016;21. PMID: 28536631IF: 10.2 Q1 B1.","DOI":"10.1186\/s11658-016-0031-z"},{"key":"8017_CR34","doi-asserted-by":"crossref","unstructured":"Li W, Wu M, Shi H, He M, Wang J, Huang Y, Xu D, Zhang J. Cadmium-induced apoptosis of granulosa cells is mediated by excessive activation of mitophagy and ROS-mediated mitochondrial dysfunction. Toxicol Appl Pharmacol. 2025;503. PMID: 40653115IF: 3.4 Q2 B3.","DOI":"10.1016\/j.taap.2025.117462"},{"key":"8017_CR35","doi-asserted-by":"crossref","unstructured":"Gu T, Kong M, Duan M, Chen L, Tian Y, Xu W, Zeng T, Lu L. Polystyrene microplastics exacerbate mitophagy through mitochondrial dysfunction in the duck lung. J Nanobiotechnology. 2025; 23. PMID: 40500713IF: 12.6 Q1 B1.","DOI":"10.1186\/s12951-025-03503-x"},{"key":"8017_CR36","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.3390\/ijms25116269]","volume":"25","author":"T Wang","year":"2024","unstructured":"Wang T, Gao T, Fujisawa M, Ohara T, Sakaguchi M, Yoshimura T, Matsukawa A. SPRED2 is a novel regulator of autophagy in hepatocellular carcinoma cells and normal hepatocytes. Int J Mol Sci. 2024;25:6269. PMID: 38892460IF: 4.9 Q1 B3.","journal-title":"Int J Mol Sci"},{"key":"8017_CR37","doi-asserted-by":"crossref","unstructured":"Kim YJ, Lee JR, Kim MR, Jeong JA, Kim JJ, Jeong KW. Protein kinase-mediated inhibition of autophagy by palmitic acid in hepatocytes. Eur J Pharmacol. 2025;998. PMID: 40113068IF: 4.7 Q1 B3 .","DOI":"10.1016\/j.ejphar.2025.177528"},{"key":"8017_CR38","doi-asserted-by":"publisher","first-page":"e102154","DOI":"10.15252\/embj.2019102154]","volume":"38","author":"H Li","year":"2019","unstructured":"Li H, Chen Q, Li C, Zhong R, Zhao Y, Zhang Q, Tong W, Zhu D, Zhang Y. Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice. EMBO J. 2019;38:e102154. PMID: 31736098IF: 8.3 Q1 B1.","journal-title":"EMBO J"},{"key":"8017_CR39","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1042\/BST20240201","volume":"52","author":"TP Saliu","year":"2024","unstructured":"Saliu TP, Goh J, Kang G, Burke BI, Ismaeel A, McCarthy JJ. Satellite cell dynamics during skeletal muscle hypertrophy. Biochem Soc Trans. 2024;52:1921\u20136. PMID: 39136196IF: 4.3 Q2 B2.","journal-title":"Biochem Soc Trans"},{"key":"8017_CR40","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.3390\/nu15071729","volume":"15","author":"A Dumond Bourie","year":"2023","unstructured":"Dumond Bourie A, Potier J-B, Pinget M, Bouzakri K. Myokines: crosstalk and consequences on liver physiopathology. Nutrients. 2023;15:1729. PMID: 37049569IF: 5.0 Q1 B2.","journal-title":"Nutrients"},{"key":"8017_CR41","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/biom15060893]","volume":"15","author":"C Zhu","year":"2025","unstructured":"Zhu C, Ding X, Chen M, Feng J, Zou J, Zhang L. Exercise-mediated skeletal muscle-derived IL-6 regulates bone metabolism: a new perspective on muscle\u2013bone crosstalk. Biomolecules. 2025;15:893. PMID: 40563533IF: 4.8 Q1 B2.","journal-title":"Biomolecules"},{"key":"8017_CR42","doi-asserted-by":"publisher","first-page":"668759","DOI":"10.3389\/fcell.2021.668759]","volume":"9","author":"L Liu","year":"2021","unstructured":"Liu L, Guo J, Chen X, Tong X, Xu J, Zou J. The role of irisin in exercise-mediated bone health. Front Cell Dev Biol. 2021;9:668759. PMID: 34017836IF: 4.3 Q1 B2.","journal-title":"Front Cell Dev Biology"},{"key":"8017_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.52547\/rbmb.10.1.13]","volume":"10","author":"A Badr Roomi","year":"2021","unstructured":"Badr Roomi A, Nori W, Mokram Hamed R. Lower serum irisin levels are associated with increased osteoporosis and oxidative stress in postmenopausal. Rep Biochem Mol Biol. 2021;10:13\u20139. PMID: 34277864IF: 1.2 Q4 B4.","journal-title":"Rep Biochem Mol Biol"},{"key":"8017_CR44","doi-asserted-by":"publisher","first-page":"e22547","DOI":"10.1016\/j.heliyon.2023.e22547]","volume":"10","author":"M Shao","year":"2024","unstructured":"Shao M, Wang Q, Lv Q, Zhang Y, Gao G, Lu S. Advances in the research on myokine-driven regulation of bone metabolism. Heliyon. 2024;10:e22547. PMID: 38226270IF: 3.6 Q1 B4.","journal-title":"Heliyon"},{"key":"8017_CR45","doi-asserted-by":"publisher","first-page":"1192458","DOI":"10.3389\/fendo.2023.1192458]","volume":"14","author":"X Yi","year":"2023","unstructured":"Yi X, Yang Y, Li T, Li M, Yao T, Hu G, Wan G, Chang B. Signaling metabolite \u03b2-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill. Front Endocrinol (Lausanne). 2023;14:1192458. PMID: 37313446IF: 4.6 Q1 B3.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"8017_CR46","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001]","volume":"22","author":"MP Jedrychowski","year":"2015","unstructured":"Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM. Detection and quantitation of circulating human irisin by tandem mass spectrometry. Cell Metab. 2015;22:734\u201340. PMID: 26278051IF: 30.9 Q1 B1.","journal-title":"Cell Metab"},{"key":"8017_CR47","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1111\/ggi.13030]","volume":"17","author":"JS Chang","year":"2017","unstructured":"Chang JS, Kim TH, Nguyen TT, Park K-S, Kim N, Kong ID. Circulating irisin levels as a predictive biomarker for sarcopenia: a cross-sectional community-based study. Geriatr Gerontol Int. 2017;17:2266\u201373. PMID: 28394089IF: 2.5 Q2 B3.","journal-title":"Geriatr Gerontol Int"},{"key":"8017_CR48","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/nu14091855","volume":"14","author":"TA Alsaawi","year":"2022","unstructured":"Alsaawi TA, Aldisi D, Abulmeaty MMA, Khattak MNK, Alnaami AM, Sabico S, Al-Daghri NM. Screening for sarcopenia among elderly arab females: influence of body composition, lifestyle, irisin, and vitamin D. Nutrients. 2022;14:1855. PMID: 35565822IF: 5.0 Q1 B2.","journal-title":"Nutrients"},{"key":"8017_CR49","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s12020-018-1814-y]","volume":"64","author":"H-S Park","year":"2019","unstructured":"Park H-S, Kim HC, Zhang D, Yeom H, Lim S-K. The novel myokine irisin: clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women. Endocrine. 2019;64:341\u20138. PMID: 30570737IF: 2.9 Q3 B3.","journal-title":"Endocrine"},{"key":"8017_CR50","doi-asserted-by":"publisher","first-page":"16093","DOI":"10.1038\/s41598-020-73176-z]","volume":"10","author":"M Zhao","year":"2020","unstructured":"Zhao M, Zhou X, Yuan C, Li R, Ma Y, Tang X. Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: a cross-sectional study. Sci Rep. 2020;10:16093. PMID: 32999391IF: 3.9 Q1 B3.","journal-title":"Sci Rep"},{"key":"8017_CR51","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.2147\/DMSO.S249090","volume":"13","author":"V Guarnotta","year":"2020","unstructured":"Guarnotta V, Prinzi A, Pitrone M, Pizzolanti G, Giordano C. Circulating Irisin levels as a marker of osteosarcopenic-obesity in cushing\u2019s disease. Diabetes Metab Syndr Obes. 2020;13:1565\u201374. PMID: 32494173IF: 3.0 Q2 B3.","journal-title":"Diabetes Metab Syndr Obes"},{"key":"8017_CR52","doi-asserted-by":"publisher","first-page":"572","DOI":"10.7150\/ijbs.63505]","volume":"18","author":"Y Xue","year":"2022","unstructured":"Xue Y, Hu S, Chen C, He J, Sun J, Jin Y, Zhang Y, Zhu G, Shi Q, Rui Y. Myokine Irisin promotes osteogenesis by activating BMP\/SMAD signaling via \u03b1V integrin and regulates bone mass in mice. Int J Biol Sci. 2022;18:572\u201384. PMID: 35002510IF: 10.0 Q1 B1.","journal-title":"Int J Biol Sci"},{"key":"8017_CR53","doi-asserted-by":"publisher","first-page":"155638","DOI":"10.1016\/j.metabol.2023.155638]","volume":"145","author":"E Gielen","year":"2023","unstructured":"Gielen E, Dupont J, Dejaeger M, Laurent MR. Sarcopenia, osteoporosis and frailty. Metabolism. 2023;145:155638. PMID: 37348597IF: 11.9 Q1 B1.","journal-title":"Metabolism"},{"key":"8017_CR54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41591-018-0275-4]","volume":"25","author":"MV Lourenco","year":"2019","unstructured":"Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gon\u00e7alves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer\u2019s models. Nat Med. 2019;25:165\u201375. PMID: 30617325IF: 50.0 Q1 B1.","journal-title":"Nat Med"},{"key":"8017_CR55","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777]","volume":"481","author":"P Bostr\u00f6m","year":"2012","unstructured":"Bostr\u00f6m P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostr\u00f6m EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, H\u00f8jlund K, Gygi SP, Spiegelman BM. A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463\u20138. PMID: 22237023IF: 48.5 Q1 B1.","journal-title":"Nature"},{"key":"8017_CR56","unstructured":"Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice."},{"key":"8017_CR57","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3390\/cells8050451","volume":"8","author":"G Colaianni","year":"2019","unstructured":"Colaianni G, Sanesi L, Storlino G, Brunetti G, Colucci S, Grano M. Irisin and bone: from preclinical studies to the evaluation of its circulating levels in different populations of human subjects. Cells. 2019;8:451. PMID: 31091695IF: 5.2 Q2 B2.","journal-title":"Cells"},{"key":"8017_CR58","doi-asserted-by":"crossref","unstructured":"Qiao X, Nie Y, Ma Y, Chen Y, Cheng R, Yin W, Hu Y, Xu W, Xu L. Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways. Sci Rep. 2016;6. PMID: 26738434IF: 3.9 Q1 B3.","DOI":"10.1038\/srep18732"},{"key":"8017_CR59","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/jcp.29894]","volume":"236","author":"X Zhu","year":"2021","unstructured":"Zhu X, Li X, Wang X, Chen T, Tao F, Liu C, Tu Q, Shen G, Chen JJ. Irisin deficiency disturbs bone metabolism. J Cell Physiol. 2021;236:664\u201376. PMID: 32572964IF: 4.0 Q1 B3.","journal-title":"J Cell Physiol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08017-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08017-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08017-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:52:35Z","timestamp":1773834755000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08017-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8017"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08017-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"7 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study was approved by the Experimental Animal Welfare Ethics Committee, Guizhou Medical University. The study was conducted in accordance with the local legislation and institutional requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The author(s) declare that no Generative AI was used in the creation of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Generative AI statement"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"389"}}