{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:14:52Z","timestamp":1776442492271,"version":"3.51.2"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Famous Doctor Project of the Xingdian Talent Support Program of Yunnan Province","award":["XDYC-MY-2022-0042"],"award-info":[{"award-number":["XDYC-MY-2022-0042"]}]},{"name":"The Key Joint Special Project for Basic Research of Kunming Medical University","award":["202501AY070001-030"],"award-info":[{"award-number":["202501AY070001-030"]}]},{"name":"The Science and Technology Talent and Platform Program of Yunnan Province","award":["202205AF150011"],"award-info":[{"award-number":["202205AF150011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08059-4","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:49:19Z","timestamp":1776358159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-cell and spatial transcriptomic analysis reveals PAX5\u2019s role and regulatory mechanisms in gastric adenocarcinoma lymph node metastasis"],"prefix":"10.1186","volume":"24","author":[{"given":"Shi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiXing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YiJun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QingWen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LinXing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuXing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShuMin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"8059_CR1","doi-asserted-by":"publisher","first-page":"646818","DOI":"10.3389\/fgene.2021.646818","volume":"12","author":"S HAN","year":"2021","unstructured":"HAN S, ZHU W, YANG W, et al. A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma[J]. Front Genet. 2021;12:646818. https:\/\/doi.org\/10.3389\/fgene.2021.646818.","journal-title":"Front Genet"},{"issue":"8","key":"8059_CR2","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.ccell.2023.06.005","volume":"41","author":"R WANG","year":"2023","unstructured":"WANG R, SONG S, QIN J, et al. Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression[J]. Cancer Cell. 2023;41(8):1407\u2013e14261409. https:\/\/doi.org\/10.1016\/j.ccell.2023.06.005.","journal-title":"Cancer Cell"},{"issue":"3","key":"8059_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H SUNG","year":"2021","unstructured":"SUNG H, FERLAY J, SIEGEL RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin. 2021;71(3):209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"8059_CR4","doi-asserted-by":"publisher","first-page":"e730","DOI":"10.1002\/ctm2.730","volume":"12","author":"H JIANG","year":"2022","unstructured":"JIANG H, YU D, YANG P, et al. Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing[J]. Clin Transl Med. 2022;12(2):e730. https:\/\/doi.org\/10.1002\/ctm2.730.","journal-title":"Clin Transl Med"},{"issue":"1","key":"8059_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","volume":"21","author":"J CHANG","year":"2023","unstructured":"CHANG J, WU H, WU J, et al. Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma[J]. J Transl Med. 2023;21(1):191. https:\/\/doi.org\/10.1186\/s12967-023-04033-6.","journal-title":"J Transl Med"},{"issue":"1","key":"8059_CR6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12916-024-03319-w","volume":"22","author":"Y LIU","year":"2024","unstructured":"LIU Y, HE M, TANG H, et al. Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma[J]. BMC Med. 2024;22(1):200. https:\/\/doi.org\/10.1186\/s12916-024-03319-w.","journal-title":"BMC Med"},{"issue":"3","key":"8059_CR7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/sj.bjc.6601571","volume":"90","author":"JD SHIELDS","year":"2004","unstructured":"SHIELDS JD, BORSETTI M, RIGBY H, et al. Lymphatic density and metastatic spread in human malignant melanoma[J]. Br J Cancer. 2004;90(3):693\u2013700. https:\/\/doi.org\/10.1038\/sj.bjc.6601571.","journal-title":"Br J Cancer"},{"issue":"3","key":"8059_CR8","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1182\/blood-2006-05-021758","volume":"109","author":"S HIRAKAWA","year":"2007","unstructured":"HIRAKAWA S, BROWN LF. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites[J]. Blood. 2007;109(3):1010\u20137. https:\/\/doi.org\/10.1182\/blood-2006-05-021758.","journal-title":"Blood"},{"issue":"7","key":"8059_CR9","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1084\/jem.20041896","volume":"201","author":"S HIRAKAWA","year":"2005","unstructured":"HIRAKAWA S, KODAMA S, KUNSTFELD R, et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis[J]. J Exp Med. 2005;201(7):1089\u201399. https:\/\/doi.org\/10.1084\/jem.20041896.","journal-title":"J Exp Med"},{"issue":"1","key":"8059_CR10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41467-023-36325-2","volume":"14","author":"T HIRZ","year":"2023","unstructured":"HIRZ T, MEI S, SARKAR H, et al. Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses[J]. Nat Commun. 2023;14(1):663. https:\/\/doi.org\/10.1038\/s41467-023-36325-2.","journal-title":"Nat Commun"},{"issue":"7","key":"8059_CR11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41575-022-00591-0","volume":"19","author":"Y ZAVROS","year":"2022","unstructured":"ZAVROS Y, MERCHANT JL. The immune microenvironment in gastric adenocarcinoma[J]. Nat Rev Gastroenterol Hepatol. 2022;19(7):451\u201367. https:\/\/doi.org\/10.1038\/s41575-022-00591-0.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6434","key":"8059_CR12","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1126\/science.aaw1219","volume":"363","author":"SG RODRIQUES","year":"2019","unstructured":"RODRIQUES SG, STICKELS RR. Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution[J]. Science. 2019;363(6434):1463\u20137. https:\/\/doi.org\/10.1126\/science.aaw1219.","journal-title":"Science"},{"issue":"1","key":"8059_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41392-022-00960-w","volume":"7","author":"L ZHANG","year":"2022","unstructured":"ZHANG L, CHEN D, SONG D, et al. Clinical and translational values of spatial transcriptomics[J]. Signal Transduct Target Ther. 2022;7(1):111. https:\/\/doi.org\/10.1038\/s41392-022-00960-w.","journal-title":"Signal Transduct Target Ther"},{"issue":"17","key":"8059_CR14","doi-asserted-by":"publisher","first-page":"e37092","DOI":"10.1016\/j.heliyon.2024.e37092","volume":"10","author":"H LU","year":"2024","unstructured":"LU H, XU Z. High infiltration of immune cells with lower immune activity mediated the heterogeneity of gastric adenocarcinoma and promoted metastasis[J]. Heliyon. 2024;10(17):e37092. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e37092.","journal-title":"Heliyon"},{"issue":"8","key":"8059_CR15","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/ijc.34172","volume":"151","author":"Y QIAN","year":"2022","unstructured":"QIAN Y, ZHAI E, CHEN S, et al. Single-cell RNA-seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer[J]. Int J Cancer. 2022;151(8):1367\u201381. https:\/\/doi.org\/10.1002\/ijc.34172.","journal-title":"Int J Cancer"},{"issue":"5","key":"8059_CR16","doi-asserted-by":"publisher","first-page":"e70622","DOI":"10.1002\/cam4.70622","volume":"14","author":"L MA","year":"2025","unstructured":"MA L, LUAN Y. Analyze the Diversity and Function of Immune Cells in the Tumor Microenvironment From the Perspective of Single-Cell RNA Sequencing[J]. Cancer Med. 2025;14(5):e70622. https:\/\/doi.org\/10.1002\/cam4.70622.","journal-title":"Cancer Med"},{"issue":"5","key":"8059_CR17","doi-asserted-by":"publisher","first-page":"100756","DOI":"10.1016\/j.mcpro.2024.100756","volume":"23","author":"Z LI","year":"2024","unstructured":"LI Z, LIU S, GAO Z, et al. Dynamic Proteomic Changes in Tumor and Immune Organs Reveal Systemic Immune Response to Tumor Development[J]. Mol Cell Proteom. 2024;23(5):100756. https:\/\/doi.org\/10.1016\/j.mcpro.2024.100756.","journal-title":"Mol Cell Proteom"},{"issue":"9","key":"8059_CR18","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1158\/1078-0432.Ccr-21-1130","volume":"28","author":"M LAUSS","year":"2022","unstructured":"LAUSS M, DONIA M, SVANE IM, et al. B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?[J]. Clin Cancer Res. 2022;28(9):1751\u20138. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-21-1130.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"8059_CR19","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1164\/rccm.201309-1611OC","volume":"189","author":"C GERMAIN","year":"2014","unstructured":"GERMAIN C, GNJATIC S, TAMZALIT F, et al. Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer[J]. Am J Respir Crit Care Med. 2014;189(7):832\u201344. https:\/\/doi.org\/10.1164\/rccm.201309-1611OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"8059_CR20","doi-asserted-by":"publisher","first-page":"605","DOI":"10.7150\/thno.105423","volume":"15","author":"X WU","year":"2025","unstructured":"WU X, HUANG Q, CHEN X, et al. B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications[J]. Theranostics. 2025;15(2):605\u201331. https:\/\/doi.org\/10.7150\/thno.105423.","journal-title":"Theranostics"},{"key":"8059_CR21","doi-asserted-by":"publisher","unstructured":"YANG H, CHEN K, MENG Y, et al. Review: radiotherapy-mediated B cells within the TLS influence the tumor microenvironment[J]. J Immunother Cancer. 2025;13(7). https:\/\/doi.org\/10.1136\/jitc-2025-011617.","DOI":"10.1136\/jitc-2025-011617"},{"key":"8059_CR22","doi-asserted-by":"publisher","unstructured":"WANG R, LAN C, BENLAGHA K, et al. The interaction of innate immune and adaptive immune system[J]. MedComm (2020). 2024; 5(10): e714. https:\/\/doi.org\/10.1002\/mco2.714","DOI":"10.1002\/mco2.714"},{"key":"8059_CR23","doi-asserted-by":"publisher","first-page":"155169","DOI":"10.1016\/j.prp.2024.155169","volume":"255","author":"N CHANDNANI","year":"2024","unstructured":"CHANDNANI N, GUPTA I, MANDAL A, et al. Participation of B cell in immunotherapy of cancer[J]. Pathol - Res Pract. 2024;255:155169. https:\/\/doi.org\/10.1016\/j.prp.2024.155169.","journal-title":"Pathol - Res Pract"},{"issue":"8","key":"8059_CR24","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/cmi.2017.35","volume":"14","author":"A SARVARIA","year":"2017","unstructured":"SARVARIA A, MADRIGAL JA. B cell regulation in cancer and anti-tumor immunity[J]. Cell Mol Immunol. 2017;14(8):662\u201374. https:\/\/doi.org\/10.1038\/cmi.2017.35.","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"8059_CR25","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1182\/blood-2003-05-1465","volume":"103","author":"C MONTESINOS-RONGEN M, VAN ROOST D, S","year":"2004","unstructured":"MONTESINOS-RONGEN M, VAN ROOST D, SCHALLER C, et al. Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation[J]. Blood. 2004;103(5):1869\u201375. https:\/\/doi.org\/10.1182\/blood-2003-05-1465.","journal-title":"Blood"},{"issue":"8","key":"8059_CR26","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1111\/cas.15856","volume":"114","author":"T WANG","year":"2023","unstructured":"WANG T, CHEN Z, LI C, et al. PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1[J]. Cancer Sci. 2023;114(8):3203\u201315. https:\/\/doi.org\/10.1111\/cas.15856.","journal-title":"Cancer Sci"},{"issue":"2","key":"8059_CR27","doi-asserted-by":"publisher","first-page":"498","DOI":"10.7150\/ijbs.55636","volume":"17","author":"SL LIU","year":"2021","unstructured":"LIU SL, CAI C, YANG ZY, et al. DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163\/TOP2A and activating Wnt\/\u03b2-catenin pathway[J]. Int J Biol Sci. 2021;17(2):498\u2013513. https:\/\/doi.org\/10.7150\/ijbs.55636.","journal-title":"Int J Biol Sci"},{"issue":"24","key":"8059_CR28","doi-asserted-by":"publisher","first-page":"7345","DOI":"10.1158\/0008-5472.Can-11-1874","volume":"71","author":"P O\u2019BRIEN","year":"2011","unstructured":"O\u2019BRIEN P, OUELLETTE MORINPJR. The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease[J]. Cancer Res. 2011;71(24):7345\u201350. https:\/\/doi.org\/10.1158\/0008-5472.Can-11-1874.","journal-title":"Cancer Res"},{"key":"8059_CR29","doi-asserted-by":"publisher","unstructured":"NASRI NASRABADI P MARTIND. The Pleiotropy of PAX5 Gene Products and Function[J]. Int J Mol Sci. 2022;23(17). https:\/\/doi.org\/10.3390\/ijms231710095.","DOI":"10.3390\/ijms231710095"},{"issue":"6","key":"8059_CR30","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N FERRARA","year":"2003","unstructured":"FERRARA N, GERBER HP, LECOUTER J. The biology of VEGF and its receptors[J]. Nat Med. 2003;9(6):669\u201376. https:\/\/doi.org\/10.1038\/nm0603-669.","journal-title":"Nat Med"},{"issue":"3","key":"8059_CR31","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/sj.bjc.6601145","volume":"89","author":"SE DUFF","year":"2003","unstructured":"DUFF SE, LI C, JEZIORSKA M, et al. Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy[J]. Br J Cancer. 2003;89(3):426\u201330. https:\/\/doi.org\/10.1038\/sj.bjc.6601145.","journal-title":"Br J Cancer"},{"issue":"5","key":"8059_CR32","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41388-020-01539-x","volume":"40","author":"D KONG","year":"2021","unstructured":"KONG D, ZHOU H. VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk[J]. Oncogene. 2021;40(5):964\u201379. https:\/\/doi.org\/10.1038\/s41388-020-01539-x.","journal-title":"Oncogene"},{"issue":"2","key":"8059_CR33","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/jso.1133","volume":"78","author":"T ICHIKURA","year":"2001","unstructured":"ICHIKURA T, TOMIMATSU S. Prognostic significance of the expression of vascular endothelial growth factor (VEGF) and VEGF-C in gastric carcinoma[J]. J Surg Oncol. 2001;78(2):132\u20137. https:\/\/doi.org\/10.1002\/jso.1133.","journal-title":"J Surg Oncol"},{"issue":"7","key":"8059_CR34","first-page":"1823","volume":"5","author":"Y YONEMURA","year":"1999","unstructured":"YONEMURA Y, ENDO Y, FUJITA H, et al. Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer[J]. Clin Cancer Res. 1999;5(7):1823\u20139.","journal-title":"Clin Cancer Res"},{"issue":"7484","key":"8059_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature12912","volume":"505","author":"MS LAWRENCE","year":"2014","unstructured":"LAWRENCE MS, STOJANOV P, MERMEL CH, et al. Discovery and saturation analysis of cancer genes across 21 tumour types[J]. Nature. 2014;505(7484):495\u2013501. https:\/\/doi.org\/10.1038\/nature12912.","journal-title":"Nature"},{"issue":"1","key":"8059_CR36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","volume":"6","author":"Y HE","year":"2021","unstructured":"HE Y, SUN MM, ZHANG GG, et al. Targeting PI3K\/Akt signal transduction for cancer therapy[J]. Signal Transduct Target Therapy. 2021;6(1):425. https:\/\/doi.org\/10.1038\/s41392-021-00828-5.","journal-title":"Signal Transduct Target Therapy"},{"key":"8059_CR37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.canlet.2019.01.008","volume":"447","author":"B WANG","year":"2019","unstructured":"WANG B, ZHAO CH. IL-17 induces the proliferation and migration of glioma cells through the activation of PI3K\/Akt1\/NF-\u03baB-p65[J]. Cancer Lett. 2019;447:93\u2013104. https:\/\/doi.org\/10.1016\/j.canlet.2019.01.008.","journal-title":"Cancer Lett"},{"issue":"3","key":"8059_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/cbf.3176","volume":"34","author":"H AKRAMI","year":"2016","unstructured":"AKRAMI H, MAHMOODI F, HAVASI S, et al. PlGF knockdown inhibited tumor survival and migration in gastric cancer cell via PI3K\/Akt and p38MAPK pathways[J]. Cell Biochem Funct. 2016;34(3):173\u201380. https:\/\/doi.org\/10.1002\/cbf.3176.","journal-title":"Cell Biochem Funct"},{"issue":"21","key":"8059_CR39","doi-asserted-by":"publisher","first-page":"5856","DOI":"10.1158\/1078-0432.Ccr-12-0662","volume":"18","author":"BM SLOMOVITZ","year":"2012","unstructured":"SLOMOVITZ BM, COLEMAN RL. The PI3K\/AKT\/mTOR pathway as a therapeutic target in endometrial cancer[J]. Clin Cancer Res. 2012;18(21):5856\u201364. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-12-0662.","journal-title":"Clin Cancer Res"},{"issue":"51","key":"8059_CR40","doi-asserted-by":"publisher","first-page":"51267","DOI":"10.1074\/jbc.M310678200","volume":"278","author":"R ZHANG","year":"2003","unstructured":"ZHANG R, XU Y, EKMAN N, et al. Etk\/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway[J]. J Biol Chem. 2003;278(51):51267\u201376. https:\/\/doi.org\/10.1074\/jbc.M310678200.","journal-title":"J Biol Chem"},{"issue":"4","key":"8059_CR41","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1582-4934.2005.tb00379.x","volume":"9","author":"HARMEYJH BYRNE AM, BOUCHIER-HAYES DJ","year":"2005","unstructured":"BYRNE AM, BOUCHIER-HAYES DJ HARMEYJH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)[J]. J Cell Mol Med. 2005;9(4):777\u201394. https:\/\/doi.org\/10.1111\/j.1582-4934.2005.tb00379.x.","journal-title":"J Cell Mol Med"},{"issue":"11","key":"8059_CR42","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s00432-011-1049-2","volume":"137","author":"C ZHU","year":"2011","unstructured":"ZHU C, QI X, CHEN Y, et al. PI3K\/Akt and MAPK\/ERK1\/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer[J]. J Cancer Res Clin Oncol. 2011;137(11):1587\u201394. https:\/\/doi.org\/10.1007\/s00432-011-1049-2.","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08059-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08059-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08059-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:29:22Z","timestamp":1776439762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08059-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8059"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08059-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"26 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has obtained approval from the Experimental Animal Welfare and Ethics Committee of the Second Affiliated Hospital of Kunming Medical University (Approval No.: kyfey2025041) and the Medical Ethics Committee of the Second Affiliated Hospital of Kunming Medical University (Review Date: August 22, 2022; Approval Date: August 30, 2022; Approval No.: Shen-PJ-Ke-2022-159). All experimental procedures in this study were conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to sample collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have given consent to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"538"}}