{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:43:23Z","timestamp":1776347003866,"version":"3.51.2"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803061"],"award-info":[{"award-number":["81803061"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009812","name":"Chinese Society of Clinical Oncology","doi-asserted-by":"publisher","award":["Z-2017-24-2108"],"award-info":[{"award-number":["Z-2017-24-2108"]}],"id":[{"id":"10.13039\/501100009812","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Commission of Hubei Province Scientific Research Project","award":["WJ2023M068"],"award-info":[{"award-number":["WJ2023M068"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08097-y","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:47:08Z","timestamp":1775821628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Gan","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyi","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-lin","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-3108","authenticated-orcid":false,"given":"Qiuji","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"8097_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","volume":"9","author":"Q Li","year":"2024","unstructured":"Li Q, Geng S, Luo H, Wang W, Mo YQ, Luo Q, Wang L, Song GB, Sheng JP, Xu B. Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy. Signal Transduct Target Ther. 2024;9:266. https:\/\/doi.org\/10.1038\/s41392-024-01953-7.","journal-title":"Signal Transduct Target Ther"},{"key":"8097_CR2","doi-asserted-by":"publisher","first-page":"eadk0642","DOI":"10.1126\/scitranslmed.adk0642","volume":"16","author":"JC Jagodinsky","year":"2024","unstructured":"Jagodinsky JC, Vera JM, Jin WJ, Shea AG, Clark PA, Sriramaneni RN, Havighurst TC, Chakravarthy I, Allawi RH, Kim K, et al. Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade. Sci Transl Med. 2024;16:eadk0642. https:\/\/doi.org\/10.1126\/scitranslmed.adk0642.","journal-title":"Sci Transl Med"},{"key":"8097_CR3","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.ccell.2021.08.008","volume":"39","author":"Y Lan","year":"2021","unstructured":"Lan Y, Moustafa M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung TL, Hasheminasab SM, Jenkins MH, Meister S, et al. Simultaneous targeting of TGF-beta\/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion. Cancer Cell. 2021;39:1388\u2013e14031310. https:\/\/doi.org\/10.1016\/j.ccell.2021.08.008.","journal-title":"Cancer Cell"},{"key":"8097_CR4","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.1158\/1078-0432.CCR-18-1038","volume":"24","author":"A Oweida","year":"2018","unstructured":"Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, et al. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018;24:5368\u201380. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-1038.","journal-title":"Clin Cancer Res"},{"key":"8097_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2022.09.022","volume":"151","author":"EM Mace","year":"2023","unstructured":"Mace EM. Human natural killer cells: Form, function, and development. J Allergy Clin Immunol. 2023;151:371\u201385. https:\/\/doi.org\/10.1016\/j.jaci.2022.09.022.","journal-title":"J Allergy Clin Immunol"},{"key":"8097_CR6","doi-asserted-by":"publisher","first-page":"896228","DOI":"10.3389\/fimmu.2022.896228","volume":"13","author":"A Ramirez-Labrada","year":"2022","unstructured":"Ramirez-Labrada A, Pesini C, Santiago L, Hidalgo S, Calvo-Perez A, Onate C, Andres-Tovar A, Garzon-Tituana M, Uranga-Murillo I, Arias MA, et al. All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity. Front Immunol. 2022;13:896228. https:\/\/doi.org\/10.3389\/fimmu.2022.896228.","journal-title":"Front Immunol"},{"key":"8097_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41573-022-00413-7","volume":"21","author":"NA Maskalenko","year":"2022","unstructured":"Maskalenko NA, Zhigarev D, Campbell KS. Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders. Nat Rev Drug Discov. 2022;21:559\u201377. https:\/\/doi.org\/10.1038\/s41573-022-00413-7.","journal-title":"Nat Rev Drug Discov"},{"key":"8097_CR8","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41590-018-0132-0","volume":"19","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, et al. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018;19:723\u201332. https:\/\/doi.org\/10.1038\/s41590-018-0132-0.","journal-title":"Nat Immunol"},{"key":"8097_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fimmu.2020.00167","volume":"11","author":"M Khan","year":"2020","unstructured":"Khan M, Arooj S, Wang H. NK Cell-Based Immune Checkpoint Inhibition. Front Immunol. 2020;11:167. https:\/\/doi.org\/10.3389\/fimmu.2020.00167.","journal-title":"Front Immunol"},{"key":"8097_CR10","doi-asserted-by":"publisher","first-page":"575609","DOI":"10.3389\/fimmu.2020.575609","volume":"11","author":"H Alfarra","year":"2020","unstructured":"Alfarra H, Weir J, Grieve S, Reiman T. Targeting NK Cell Inhibitory Receptors for Precision Multiple Myeloma Immunotherapy. Front Immunol. 2020;11:575609. https:\/\/doi.org\/10.3389\/fimmu.2020.575609.","journal-title":"Front Immunol"},{"key":"8097_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","volume":"18","author":"JA Myers","year":"2021","unstructured":"Myers JA, Miller JS. Exploring the NK cell platform for cancer immunotherapy. Nat Rev Clin Oncol. 2021;18:85\u2013100. https:\/\/doi.org\/10.1038\/s41571-020-0426-7.","journal-title":"Nat Rev Clin Oncol"},{"key":"8097_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","volume":"20","author":"Y Wolf","year":"2020","unstructured":"Wolf Y, Anderson AC, Kuchroo VK. TIM3 comes of age as an inhibitory receptor. Nat Rev Immunol. 2020;20:173\u201385. https:\/\/doi.org\/10.1038\/s41577-019-0224-6.","journal-title":"Nat Rev Immunol"},{"key":"8097_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.immuni.2024.01.010","volume":"57","author":"N Joller","year":"2024","unstructured":"Joller N, Anderson AC, Kuchroo VK. LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation. Immunity. 2024;57:206\u201322. https:\/\/doi.org\/10.1016\/j.immuni.2024.01.010.","journal-title":"Immunity"},{"key":"8097_CR14","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1182\/blood-2011-11-392951","volume":"119","author":"LC Ndhlovu","year":"2012","unstructured":"Ndhlovu LC, Lopez-Verges S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012;119:3734\u201343. https:\/\/doi.org\/10.1182\/blood-2011-11-392951.","journal-title":"Blood"},{"key":"8097_CR15","doi-asserted-by":"publisher","first-page":"eadp7302","DOI":"10.1126\/sciimmunol.adp7302","volume":"9","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Ren C, Xiao R, Ma S, Liu H, Dou Y, Fan Y, Wang S, Zhan P, Gao C, et al. Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity. Sci Immunol. 2024;9:eadp7302. https:\/\/doi.org\/10.1126\/sciimmunol.adp7302.","journal-title":"Sci Immunol"},{"key":"8097_CR16","doi-asserted-by":"publisher","unstructured":"Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, et al. The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Sci Immunol. 2016;1. https:\/\/doi.org\/10.1126\/sciimmunol.aai8593.","DOI":"10.1126\/sciimmunol.aai8593"},{"key":"8097_CR17","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/s41586-018-0206-z","volume":"558","author":"N Chihara","year":"2018","unstructured":"Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, et al. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018;558:454\u20139. https:\/\/doi.org\/10.1038\/s41586-018-0206-z.","journal-title":"Nature"},{"key":"8097_CR18","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1158\/0008-5472.CAN-19-2332","volume":"80","author":"S Tan","year":"2020","unstructured":"Tan S, Xu Y, Wang Z, Wang T, Du X, Song X, Guo X, Peng J, Zhang J, Liang Y, et al. Tim-3 Hampers Tumor Surveillance of Liver-Resident and Conventional NK Cells by Disrupting PI3K Signaling. Cancer Res. 2020;80:1130\u201342. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-2332.","journal-title":"Cancer Res"},{"key":"8097_CR19","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.intimp.2015.09.017","volume":"29","author":"L Xu","year":"2015","unstructured":"Xu L, Huang Y, Tan L, Yu W, Chen D, Lu C, He J, Wu G, Liu X, Zhang Y. Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma. Int Immunopharmacol. 2015;29:635\u201341. https:\/\/doi.org\/10.1016\/j.intimp.2015.09.017.","journal-title":"Int Immunopharmacol"},{"key":"8097_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12967-019-1917-0","volume":"17","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Li Y, Lian J, Yang H, Li F, Zhao S, Qi Y, Zhang Y, Huang L. TNF-alpha-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer. J Transl Med. 2019;17:165. https:\/\/doi.org\/10.1186\/s12967-019-1917-0.","journal-title":"J Transl Med"},{"key":"8097_CR21","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1158\/2326-6066.CIR-13-0171","volume":"2","author":"IP da Silva","year":"2014","unstructured":"da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol Res. 2014;2:410\u201322. https:\/\/doi.org\/10.1158\/2326-6066.CIR-13-0171.","journal-title":"Cancer Immunol Res"},{"key":"8097_CR22","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10555-023-10153-8","volume":"43","author":"S Anand","year":"2024","unstructured":"Anand S, Vikramdeo KS, Sudan SK, Sharma A, Acharya S, Khan MA, Singh S, Singh AP. From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies. Cancer Metastasis Rev. 2024;43:409\u201321. https:\/\/doi.org\/10.1007\/s10555-023-10153-8.","journal-title":"Cancer Metastasis Rev"},{"key":"8097_CR23","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1158\/2326-6066.CIR-22-0912","volume":"11","author":"M van Gogh","year":"2023","unstructured":"van Gogh M, Glaus Garzon JF, Sahin D, Knopfova L, Benes P, Boyman O, Jurisica I, Borsig L. Tumor Cell-Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model. Cancer Immunol Res. 2023;11:1432\u201344. https:\/\/doi.org\/10.1158\/2326-6066.CIR-22-0912.","journal-title":"Cancer Immunol Res"},{"key":"8097_CR24","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.neo.2021.01.002","volume":"23","author":"M Ducka","year":"2021","unstructured":"Ducka M, Kucerikova M, Trcka F, Cervinka J, Biglieri E, Smarda J, Borsig L, Benes P, Knopfova L. c-Myb interferes with inflammatory IL1alpha-NF-kappaB pathway in breast cancer cells. Neoplasia. 2021;23:326\u201336. https:\/\/doi.org\/10.1016\/j.neo.2021.01.002.","journal-title":"Neoplasia"},{"key":"8097_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41586-022-05105-1","volume":"609","author":"C Tsui","year":"2022","unstructured":"Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knopper K, Utzschneider DT, Nussing S, Liao Y, Mason T, et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. 2022;609:354\u201360. https:\/\/doi.org\/10.1038\/s41586-022-05105-1.","journal-title":"Nature"},{"key":"8097_CR26","doi-asserted-by":"publisher","first-page":"e464","DOI":"10.1002\/ctm2.464","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F. c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p\/SPOP\/PD-L1 axis. Clin Transl Med. 2021;11:e464. https:\/\/doi.org\/10.1002\/ctm2.464.","journal-title":"Clin Transl Med"},{"key":"8097_CR27","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.bbrc.2018.08.044","volume":"503","author":"HW Shin","year":"2018","unstructured":"Shin HW, Lee YJ, Kim J. Role of c-Myb in the regulation of natural killer cell activity. Biochem Biophys Res Commun. 2018;503:2807\u201313. https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.044.","journal-title":"Biochem Biophys Res Commun"},{"key":"8097_CR28","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1158\/0008-5472.CAN-12-0210","volume":"72","author":"I Verbrugge","year":"2012","unstructured":"Verbrugge I, Hagekyriakou J, Sharp LL, Galli M, West A, McLaughlin NM, Duret H, Yagita H, Johnstone RW, Smyth MJ, et al. Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Cancer Res. 2012;72:3163\u201374. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-0210.","journal-title":"Cancer Res"},{"key":"8097_CR29","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1158\/0008-5472.CAN-11-0096","volume":"71","author":"SF Ngiow","year":"2011","unstructured":"Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res. 2011;71:3540\u201351. https:\/\/doi.org\/10.1158\/0008-5472.CAN-11-0096.","journal-title":"Cancer Res"},{"key":"8097_CR30","doi-asserted-by":"publisher","first-page":"e1261779","DOI":"10.1080\/2162402X.2016.1261779","volume":"6","author":"G Shayan","year":"2017","unstructured":"Shayan G, Srivastava R, Li J, Schmitt N, Kane LP, Ferris RL. Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Oncoimmunology. 2017;6:e1261779. https:\/\/doi.org\/10.1080\/2162402X.2016.1261779.","journal-title":"Oncoimmunology"},{"key":"8097_CR31","doi-asserted-by":"publisher","unstructured":"Stepanyan L, Sargsyan T, Mittova V, Tsetskhladze ZR, Motsonelidze N, Gorgoshidze E, Nova N, Israyelyan M, Simonyan H, Bisceglie F, et al. The Synthesis, characterization, and biological evaluation of a fluorenyl-methoxycarbonyl-containing thioxo-triazole-bearing dipeptide: antioxidant, antimicrobial, and BSA\/DNA binding studies for potential therapeutic applications in ROS scavenging and drug transport. Biomolecules. 2025;15. https:\/\/doi.org\/10.3390\/biom15070933.","DOI":"10.3390\/biom15070933"},{"key":"8097_CR32","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.ijrobp.2021.12.162","volume":"112","author":"SS Du","year":"2022","unstructured":"Du SS, Chen GW, Yang P, Chen YX, Hu Y, Zhao QQ, Zhang Y, Liu R, Zheng DX, Zhou J, et al. Radiation Therapy Promotes Hepatocellular Carcinoma Immune Cloaking via PD-L1 Upregulation Induced by cGAS-STING Activation. Int J Radiat Oncol Biol Phys. 2022;112:1243\u201355. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.12.162.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"8097_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.12.034","volume":"529","author":"G Tan","year":"2022","unstructured":"Tan G, Lin C, Huang C, Chen B, Chen J, Shi Y, Zhi F. Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E. Cancer Lett. 2022;529:1\u201310. https:\/\/doi.org\/10.1016\/j.canlet.2021.12.034.","journal-title":"Cancer Lett"},{"key":"8097_CR34","doi-asserted-by":"publisher","unstructured":"Makowska A, Lelabi N, Nothbaum C, Shen L, Busson P, Tran TTB, Eble M, Kontny U. Radiotherapy combined with PD-1 inhibition increases NK cell cytotoxicity towards nasopharyngeal carcinoma cells. Cells. 2021;10. https:\/\/doi.org\/10.3390\/cells10092458.","DOI":"10.3390\/cells10092458"},{"key":"8097_CR35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.jcyt.2022.05.004","volume":"24","author":"EK Jung","year":"2022","unstructured":"Jung EK, Chu TH, Vo MC, Nguyen HPQ, Lee DH, Lee JK, Lim SC, Jung SH, Yoon TM, Yoon MS, et al. Natural killer cells have a synergistic anti-tumor effect in combination with chemoradiotherapy against head and neck cancer. Cytotherapy. 2022;24:905\u201315. https:\/\/doi.org\/10.1016\/j.jcyt.2022.05.004.","journal-title":"Cytotherapy"},{"key":"8097_CR36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fonc.2015.00035","volume":"5","author":"M de Bruyn","year":"2015","unstructured":"de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E. The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Front Oncol. 2015;5:35. https:\/\/doi.org\/10.3389\/fonc.2015.00035.","journal-title":"Front Oncol"},{"key":"8097_CR37","doi-asserted-by":"publisher","first-page":"705361","DOI":"10.3389\/fimmu.2021.705361","volume":"12","author":"M Zhu","year":"2021","unstructured":"Zhu M, Yang M, Zhang J, Yin Y, Fan X, Zhang Y, Qin S, Zhang H, Yu F. Immunogenic Cell Death Induction by Ionizing Radiation. Front Immunol. 2021;12:705361. https:\/\/doi.org\/10.3389\/fimmu.2021.705361.","journal-title":"Front Immunol"},{"key":"8097_CR38","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.3389\/fimmu.2018.03077","volume":"9","author":"TB Dar","year":"2018","unstructured":"Dar TB, Henson RM, Shiao SL. Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy. Front Immunol. 2018;9:3077. https:\/\/doi.org\/10.3389\/fimmu.2018.03077.","journal-title":"Front Immunol"},{"key":"8097_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/emm.2006.56","volume":"38","author":"JY Kim","year":"2006","unstructured":"Kim JY, Son YO, Park SW, Bae JH, Chung JS, Kim HH, Chung BS, Kim SH, Kang CD. Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation. Exp Mol Med. 2006;38:474\u201384. https:\/\/doi.org\/10.1038\/emm.2006.56.","journal-title":"Exp Mol Med"},{"key":"8097_CR40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40779-018-0156-7","volume":"5","author":"R Yahyapour","year":"2018","unstructured":"Yahyapour R, Amini P, Rezapour S, Cheki M, Rezaeyan A, Farhood B, Shabeeb D, Musa AE, Fallah H, Najafi M. Radiation-induced inflammation and autoimmune diseases. Mil Med Res. 2018;5:9. https:\/\/doi.org\/10.1186\/s40779-018-0156-7.","journal-title":"Mil Med Res"},{"key":"8097_CR41","doi-asserted-by":"publisher","unstructured":"Wang J, Li H, Kulkarni A, Anderson JL, Upadhyay P, Onyekachi OV, Arantes L, Banerjee H, Kane LP, Zhang X, et al. Differential impact of TIM-3 ligands on NK cell function. J Immunother Cancer. 2025;13. https:\/\/doi.org\/10.1136\/jitc-2024-010618.","DOI":"10.1136\/jitc-2024-010618"},{"key":"8097_CR42","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.jhep.2009.12.005","volume":"52","author":"Y Ju","year":"2010","unstructured":"Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, Liu Y, Zhu F, Zhang L, Sun W, et al. T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol. 2010;52:322\u20139. https:\/\/doi.org\/10.1016\/j.jhep.2009.12.005.","journal-title":"J Hepatol"},{"key":"8097_CR43","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI67313","volume":"124","author":"L Deng","year":"2014","unstructured":"Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124:687\u201395. https:\/\/doi.org\/10.1172\/JCI67313.","journal-title":"J Clin Invest"},{"key":"8097_CR44","doi-asserted-by":"publisher","first-page":"5458","DOI":"10.1158\/0008-5472.CAN-14-1258","volume":"74","author":"SJ Dovedi","year":"2014","unstructured":"Dovedi SJ, Adlard AL, Lipowska-Bhalla G, McKenna C, Jones S, Cheadle EJ, Stratford IJ, Poon E, Morrow M, Stewart R, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 2014;74:5458\u201368. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-1258.","journal-title":"Cancer Res"},{"key":"8097_CR45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00262-022-03227-z","volume":"72","author":"K Zhao","year":"2023","unstructured":"Zhao K, Jiang L, Si Y, Zhou S, Huang Z, Meng X. TIGIT blockade enhances tumor response to radiotherapy via a CD103\u2009+\u2009dendritic cell-dependent mechanism. Cancer Immunol Immunother. 2023;72:193\u2013209. https:\/\/doi.org\/10.1007\/s00262-022-03227-z.","journal-title":"Cancer Immunol Immunother"},{"key":"8097_CR46","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.canlet.2020.01.039","volume":"479","author":"MV Yusenko","year":"2020","unstructured":"Yusenko MV, Trentmann A, Andersson MK, Ghani LA, Jakobs A, Arteaga Paz MF, Mikesch JH, von Peter J, Stenman G, Klempnauer KH. Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells. Cancer Lett. 2020;479:61\u201370. https:\/\/doi.org\/10.1016\/j.canlet.2020.01.039.","journal-title":"Cancer Lett"},{"key":"8097_CR47","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.7150\/ijbs.72386","volume":"18","author":"K Du","year":"2022","unstructured":"Du K, Sun S, Jiang T, Liu T, Zuo X, Xia X, Liu X, Wang Y, Bu Y. E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. Int J Biol Sci. 2022;18:4151\u201370. https:\/\/doi.org\/10.7150\/ijbs.72386.","journal-title":"Int J Biol Sci"},{"key":"8097_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41389-021-00309-y","volume":"10","author":"Y Ciciro","year":"2021","unstructured":"Ciciro Y, Sala A. MYB oncoproteins: emerging players and potential therapeutic targets in human cancer. Oncogenesis. 2021;10:19. https:\/\/doi.org\/10.1038\/s41389-021-00309-y.","journal-title":"Oncogenesis"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08097-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08097-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08097-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:47:51Z","timestamp":1776343671000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08097-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8097"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08097-y","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"11 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University (Approval No. 2025115K). Written informed consent was obtained from all patients prior to the collection of CRC samples. In vivo experiments were conducted following the guidelines and approval from the Animal Ethics Committee of Wuhan University (Approval No. ZN2025091).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"521"}}