{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:16:41Z","timestamp":1789611401401,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500718"],"award-info":[{"award-number":["31500718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004610","name":"Science and Technology Support Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231203"],"award-info":[{"award-number":["BK20231203"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SYW2025032"],"award-info":[{"award-number":["SYW2025032"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016803","name":"Natural Science Foundation of Suzhou Municipality","doi-asserted-by":"publisher","award":["SYW2025119"],"award-info":[{"award-number":["SYW2025119"]}],"id":[{"id":"10.13039\/100016803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08151-9","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:53:27Z","timestamp":1778169207000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["B7-H3 interaction with cMet enhances lipolysis to drive malignant progression of glioma via pSTAT3-ATGL axis"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaohan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-054X","authenticated-orcid":false,"given":"Yunyun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"issue":"3","key":"8151_CR1","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/neuonc\/noad207","volume":"26","author":"J DeSisto","year":"2024","unstructured":"DeSisto J, Donson AM, Griesinger AM, Fu R, Riemondy K, Mulcahy Levy J, Siegenthaler JA, Foreman NK, Vibhakar R, Green AL. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma. Neuro Oncol. 2024;26(3):538\u201352.","journal-title":"Neuro Oncol"},{"issue":"1","key":"8151_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13287-025-04352-z","volume":"16","author":"J He","year":"2025","unstructured":"He J, Yan X, Hu S. Glioma stem cells: drivers of tumor progression and recurrence. Stem Cell Res Ther. 2025;16(1):293.","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"8151_CR3","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.7150\/thno.41219","volume":"10","author":"B Han","year":"2020","unstructured":"Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, Zha C, Ye Q, Jiang C, Cai J, et al. ATRX\/EZH2 complex epigenetically regulates FADD\/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10(7):3351\u201365.","journal-title":"Theranostics"},{"issue":"4","key":"8151_CR4","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/neuonc\/noad233","volume":"26","author":"J Zhang","year":"2024","unstructured":"Zhang J, Liu B, Xu C, Ji C, Yin A, Liu Y, Yao Y, Li B, Chen T, Shen L, et al. Cholesterol homeostasis confers glioma malignancy triggered by hnRNPA2B1-dependent regulation of SREBP2 and LDLR. Neuro Oncol. 2024;26(4):684\u2013700.","journal-title":"Neuro Oncol"},{"key":"8151_CR5","doi-asserted-by":"crossref","unstructured":"Vijayanathan Y, Ho IAW. The impact of metabolic rewiring in glioblastoma: the immune landscape and therapeutic strategies. Int J Mol Sci. 2025;26(2).","DOI":"10.3390\/ijms26020669"},{"issue":"1","key":"8151_CR6","doi-asserted-by":"publisher","first-page":"2422268","DOI":"10.1080\/17590914.2024.2422268","volume":"16","author":"DC Lee","year":"2024","unstructured":"Lee DC, Ta L, Mukherjee P, Duraj T, Domin M, Greenwood B, Karmacharya S, Narain NR, Kiebish M, Chinopoulos C, et al. Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells. ASN Neuro. 2024;16(1):2422268.","journal-title":"ASN Neuro"},{"issue":"1","key":"8151_CR7","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1158\/2159-8290.CD-22-0750","volume":"13","author":"NA Vitanza","year":"2023","unstructured":"Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, et al. Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety. Cancer Discov. 2023;13(1):114\u201331.","journal-title":"Cancer Discov"},{"issue":"9","key":"8151_CR8","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.7150\/jca.90819","volume":"15","author":"Y Wu","year":"2024","unstructured":"Wu Y, Han W, Tang X, Liu J, Guo Z, Li Z, Cai C, Que L. B7-H3 suppresses CD8(+) T cell immunologic function through reprogramming glycolytic metabolism. J Cancer. 2024;15(9):2505\u201317.","journal-title":"J Cancer"},{"issue":"17","key":"8151_CR9","doi-asserted-by":"publisher","first-page":"eabm7012","DOI":"10.1126\/sciadv.abm7012","volume":"8","author":"E Picarda","year":"2022","unstructured":"Picarda E, Galbo PM Jr., Zong H, Rajan MR, Wallenius V, Zheng D, Borgeson E, Singh R, Pessin J, Zang X. The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development. Sci Adv. 2022;8(17):eabm7012.","journal-title":"Sci Adv"},{"key":"8151_CR10","doi-asserted-by":"crossref","unstructured":"Xu Y, Lou D, Chen P, Li G, Usoskin D, Pan J, Li F, Huang S, Hess C, Tang R, et al. Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity. Dev Cell. 2025.","DOI":"10.1016\/j.devcel.2025.04.013"},{"issue":"1","key":"8151_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1158\/0008-5472.CAN-14-3595","volume":"76","author":"C Xing","year":"2016","unstructured":"Xing C, Lu XX, Guo PD, Shen T, Zhang S, He XS, Gan WJ, Li XM, Wang JR, Zhao YY, et al. Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. Cancer Res. 2016;76(1):83\u201395.","journal-title":"Cancer Res"},{"issue":"6","key":"8151_CR12","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.ccell.2019.05.003","volume":"35","author":"P Chen","year":"2019","unstructured":"Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35(6):868\u201384. e866.","journal-title":"Cancer Cell"},{"key":"8151_CR13","doi-asserted-by":"crossref","unstructured":"Zhang J, Li H, Tao W, Zhou JJMR. GseaVis: An R package for enhanced visualization of gene set enrichment analysis in biomedicine. 2025.","DOI":"10.1002\/mdr2.70000"},{"issue":"12","key":"8151_CR14","doi-asserted-by":"publisher","first-page":"100910","DOI":"10.1016\/j.crmeth.2024.100910","volume":"4","author":"D Zeng","year":"2024","unstructured":"Zeng D, Fang Y, Qiu W, Luo P, Wang S, Shen R, Gu W, Huang X, Mao Q, Wang G, et al. Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0. Cell Rep Methods. 2024;4(12):100910.","journal-title":"Cell Rep Methods"},{"key":"8151_CR15","doi-asserted-by":"crossref","unstructured":"Cao L, Xu Y, Hu Y, Huang X, Fu F, Zhan S, Huang L, Feng Y, Irene Y, Li H, et al. Identification of c-Met on tumor cells as a novel receptor for B7-H3 entails implications for cancer cell stemness and targeted therapy. MedComm. 2025;6(9):e70332.","DOI":"10.1002\/mco2.70332"},{"issue":"8","key":"8151_CR16","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/j.cmet.2024.06.015","volume":"36","author":"P Sun","year":"2024","unstructured":"Sun P, Ma L, Lu Z. Lactylation: Linking the Warburg effect to DNA damage repair. Cell Metab. 2024;36(8):1637\u20139.","journal-title":"Cell Metab"},{"issue":"1","key":"8151_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.molcel.2019.07.007","volume":"76","author":"X Wang","year":"2019","unstructured":"Wang X, Liu R, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, et al. alpha-Ketoglutarate-Activated NF-kappaB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development. Mol Cell. 2019;76(1):148\u2013e162147.","journal-title":"Mol Cell"},{"issue":"5","key":"8151_CR18","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.immuni.2024.04.006","volume":"57","author":"A De Leo","year":"2024","unstructured":"De Leo A, Ugolini A, Yu X, Scirocchi F, Scocozza D, Peixoto B, Pace A, D\u2019Angelo L, Liu JKC, Etame AB, et al. Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma. Immunity. 2024;57(5):1105\u201323. e1108.","journal-title":"Immunity"},{"key":"8151_CR19","doi-asserted-by":"publisher","first-page":"113062","DOI":"10.1016\/j.intimp.2024.113062","volume":"142Pt A","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Yao L, Ma T, Wang Z, Yin Y, Yang J, Zhang X, Zhang M, Qin G, Ma J, et al. Indoleamine 2,3-dioxygenase-1 involves in CD8(+)T cell exhaustion in glioblastoma via regulating tryptophan levels. Int Immunopharmacol. 2024;142Pt A:113062.","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"8151_CR20","doi-asserted-by":"publisher","first-page":"168013","DOI":"10.1016\/j.bbadis.2025.168013","volume":"1871","author":"Z Zhou","year":"2025","unstructured":"Zhou Z, Wang Y, Wang Y, Yuan C, Lin J, Bai X, Chen Y, Hu M, Ding X. Glioma cells produce soluble PD-L1 via the Wnt\/beta-catenin signaling pathway to suppress CD8\u2009+\u2009T cell activity. Biochim Biophys Acta Mol Basis Dis. 2025;1871(8):168013.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"8151_CR21","doi-asserted-by":"publisher","first-page":"114890","DOI":"10.1016\/j.biopha.2023.114890","volume":"163","author":"K Mortezaee","year":"2023","unstructured":"Mortezaee K. B7-H3 immunoregulatory roles in cancer. Biomed Pharmacother. 2023;163:114890.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"8151_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1158\/2326-6066.CIR-21-0407","volume":"10","author":"T Miyamoto","year":"2022","unstructured":"Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, et al. B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression. Cancer Immunol Res. 2022;10(1):56\u201369.","journal-title":"Cancer Immunol Res"},{"issue":"3","key":"8151_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41423-019-0305-2","volume":"17","author":"D Cai","year":"2020","unstructured":"Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, Li P, Lyu N, Sun T, Xie S, et al. Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cell Mol Immunol. 2020;17(3):227\u201336.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"8151_CR24","doi-asserted-by":"publisher","first-page":"6891","DOI":"10.18632\/oncotarget.6902","volume":"7","author":"CE Nunes-Xavier","year":"2016","unstructured":"Nunes-Xavier CE, Karlsen KF, Tekle C, Pedersen C, Oyjord T, Hongisto V, Nesland JM, Tan M, Sahlberg KK, Fodstad O. Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT\/mTOR inhibitors. Oncotarget. 2016;7(6):6891\u2013901.","journal-title":"Oncotarget"},{"issue":"6","key":"8151_CR25","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.7150\/thno.105947","volume":"15","author":"Z Ma","year":"2025","unstructured":"Ma Z, Yang J, Jia W, Li L, Li Y, Hu J, Luo W, Li R, Ye D, Lan P. Histone lactylation-driven B7-H3 expression promotes tumor immune evasion. Theranostics. 2025;15(6):2338\u201359.","journal-title":"Theranostics"},{"issue":"4","key":"8151_CR26","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41419-019-1549-6","volume":"10","author":"T Shi","year":"2019","unstructured":"Shi T, Ma Y, Cao L, Zhan S, Xu Y, Fu F, Liu C, Zhang G, Wang Z, Wang R, et al. B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2. Cell Death Dis. 2019;10(4):308.","journal-title":"Cell Death Dis"},{"issue":"5","key":"8151_CR27","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1158\/0008-5472.CAN-23-0555","volume":"84","author":"D Awad","year":"2024","unstructured":"Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, et al. Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity. Cancer Res. 2024;84(5):703\u201324.","journal-title":"Cancer Res"},{"key":"8151_CR28","doi-asserted-by":"publisher","first-page":"110719","DOI":"10.1016\/j.cellsig.2023.110719","volume":"108","author":"J Tian","year":"2023","unstructured":"Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, et al. Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism. Cell Signal. 2023;108:110719.","journal-title":"Cell Signal"},{"issue":"33","key":"8151_CR29","doi-asserted-by":"publisher","first-page":"eado1533","DOI":"10.1126\/sciadv.ado1533","volume":"10","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Chu P, Wang Y, Li N, Gao Q, Wang S, Wei J, Xue G, Zhao Y, Jia H, et al. Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22-mediated lipolysis circuit. Sci Adv. 2024;10(33):eado1533.","journal-title":"Sci Adv"},{"issue":"12","key":"8151_CR30","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrm1261","volume":"4","author":"C Birchmeier","year":"2003","unstructured":"Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4(12):915\u201325.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"8151_CR31","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13046-019-1264-2","volume":"38","author":"R Vengoji","year":"2019","unstructured":"Vengoji R, Macha MA, Nimmakayala RK, Rachagani S, Siddiqui JA, Mallya K, Gorantla S, Jain M, Ponnusamy MP, Batra SK, et al. Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells. J Exp Clin Cancer Res. 2019;38(1):266.","journal-title":"J Exp Clin Cancer Res"},{"key":"8151_CR32","doi-asserted-by":"publisher","first-page":"20484","DOI":"10.1038\/srep20484","volume":"6","author":"J Hu","year":"2016","unstructured":"Hu J, Che L, Li L, Pilo MG, Cigliano A, Ribback S, Li X, Latte G, Mela M, Evert M, et al. Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1\/FASN pathway in mice. Sci Rep. 2016;6:20484.","journal-title":"Sci Rep"},{"issue":"1","key":"8151_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41591-019-0716-8","volume":"26","author":"A Drilon","year":"2020","unstructured":"Drilon A, Clark JW, Weiss J, Ou SI, Camidge DR, Solomon BJ, Otterson GA, Villaruz LC, Riely GJ, Heist RS, et al. Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration. Nat Med. 2020;26(1):47\u201351.","journal-title":"Nat Med"},{"issue":"6","key":"8151_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.trecan.2018.03.010","volume":"4","author":"K Flem-Karlsen","year":"2018","unstructured":"Flem-Karlsen K, Fodstad O, Tan M, Nunes-Xavier CE. B7-H3 in Cancer - Beyond Immune Regulation. Trends Cancer. 2018;4(6):401\u20134.","journal-title":"Trends Cancer"},{"issue":"11","key":"8151_CR35","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1093\/cvr\/cvab182","volume":"118","author":"A Thiele","year":"2022","unstructured":"Thiele A, Luettges K, Ritter D, Beyhoff N, Smeir E, Grune J, Steinhoff JS, Schupp M, Klopfleisch R, Rothe M, et al. Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage. Cardiovasc Res. 2022;118(11):2488\u2013505.","journal-title":"Cardiovasc Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08151-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08151-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08151-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:22:32Z","timestamp":1782951752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08151-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8151"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08151-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was carried out in accordance with guidelines outlined in the Declaration of Helsinki and approved by the First Hospital Affiliated to Soochow University for the Biomedical Research Ethics Committee. And all animal experiments were done in the animal laboratory center as per the study protocol according to the NIH Guide for the Care and Use of Laboratory Animals, approved by the Animal Care and Use Committee of Soochow University (SUDA20250507A05).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"840"}}