{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:57:53Z","timestamp":1781067473335,"version":"3.54.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":51,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Sibylla-Hesse Foundation","award":["Sibylla-Hesse Foundation"],"award-info":[{"award-number":["Sibylla-Hesse Foundation"]}]},{"name":"The Open Medicine Foundation Canada","award":["The Open Medicine Foundation Canada"],"award-info":[{"award-number":["The Open Medicine Foundation Canada"]}]},{"DOI":"10.13039\/501100009307","name":"Parkinson Canada","doi-asserted-by":"crossref","award":["Parkinson Canada"],"award-info":[{"award-number":["Parkinson Canada"]}],"id":[{"id":"10.13039\/501100009307","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lapar\u00e9 and Legault Funds in Biochemistry for Research in RNA Biology and Neurodegenerative Diseases","award":["Lapar\u00e9 and Legault Funds in Biochemistry for Research in RNA Biology and Neurodegenerative Diseases"],"award-info":[{"award-number":["Lapar\u00e9 and Legault Funds in Biochemistry for Research in RNA Biology and Neurodegenerative Diseases"]}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["PJT 186036"],"award-info":[{"award-number":["PJT 186036"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bristol-Myers-Squibb Chair in Molecular Biology at the Universit\u00e9 de Montr\u00e9al","award":["Bristol-Myers-Squibb Chair in Molecular Biology at the Universit\u00e9 de Montr\u00e9al"],"award-info":[{"award-number":["Bristol-Myers-Squibb Chair in Molecular Biology at the Universit\u00e9 de Montr\u00e9al"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08162-6","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:39:09Z","timestamp":1776713949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PTPRN2 hypomethylation and PHB2-associated miR-153-3p maturation define dual epigenetic features linked to symptom variability in Myalgic encephalomyelitis"],"prefix":"10.1186","volume":"24","author":[{"given":"Lynda","family":"Chalder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam","family":"Elremaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iurie","family":"Caraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Leveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elbakry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Godbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Di Tomasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evguenia","family":"Nepotchatykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Rostami-Afshari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Legault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1144-6174","authenticated-orcid":false,"given":"Alain","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"9","key":"8162_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nrn3087","volume":"12","author":"ST Holgate","year":"2011","unstructured":"Holgate ST, Komaroff AL, Mangan D, Wessely S. Chronic fatigue syndrome: understanding a complex illness. Nat Rev Neurosci. 2011;12(9):539\u201344.","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"8162_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12967-020-02455-0","volume":"18","author":"EJ Lim","year":"2020","unstructured":"Lim EJ, Son CG. Review of case definitions for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). J Transl Med. 2020;18(1):289.","journal-title":"J Transl Med"},{"key":"8162_CR3","doi-asserted-by":"crossref","unstructured":"Holtzman CS, Bhatia S, Cotler J, Jason LA. Assessment of post-exertional malaise (PEM) in patients with myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS): a patient-driven survey. Diagnostics (Basel). 2019;9(1).","DOI":"10.3390\/diagnostics9010026"},{"key":"8162_CR4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fped.2019.00082","volume":"7","author":"TE Davenport","year":"2019","unstructured":"Davenport TE, Lehnen M, Stevens SR, VanNess JM, Stevens J, Snell CRJF. Chronotropic intolerance: an overlooked determinant of symptoms and activity limitation in myalgic encephalomyelitis\/chronic fatigue syndrome? Front Pead. 2019;7:82.","journal-title":"Front Pead"},{"key":"8162_CR5","doi-asserted-by":"crossref","unstructured":"Baraniuk JN. Review of the midbrain ascending arousal network nuclei and implications for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), gulf war illness (GWI) and postexertional malaise (PEM). Brain Sci. 2022;12(2).","DOI":"10.3390\/brainsci12020132"},{"key":"8162_CR6","doi-asserted-by":"publisher","first-page":"100995","DOI":"10.1016\/j.yfrne.2022.100995","volume":"66","author":"N Thomas","year":"2022","unstructured":"Thomas N, Gurvich C, Huang K, Gooley PR, Armstrong, CWJFin. The underlying sex differences in neuroendocrine adaptations relevant to myalgic encephalomyelitis chronic fatigue syndrome. Front Neuroendocr. 2022;66:100995.","journal-title":"Front Neuroendocr"},{"key":"8162_CR7","doi-asserted-by":"crossref","unstructured":"Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis\/chronic fatigue syndrome: a comprehensive review. Diagnostics (Basel). 2019;9(3).","DOI":"10.3390\/diagnostics9030091"},{"key":"8162_CR8","doi-asserted-by":"crossref","unstructured":"Sweetman E, Noble A, Edgar C, Mackay A, Helliwell A, Vallings R, et al. Current research provides insight into the biological basis and diagnostic potential for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Diagnostics (Basel). 2019;9(3).","DOI":"10.3390\/diagnostics9030073"},{"key":"8162_CR9","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3389\/fimmu.2019.00796","volume":"10","author":"JM Cliff","year":"2019","unstructured":"Cliff JM, King EC, Lee JS, Sep\u00falveda N, Wolf AS, Kingdon C, et al. Cellular Immune Function in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). Front Immunol. 2019;10:796.","journal-title":"Front Immunol"},{"issue":"5","key":"8162_CR10","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/s41591-022-01810-6","volume":"28","author":"J Choutka","year":"2022","unstructured":"Choutka J, Jansari V, Hornig M, Iwasaki A. Unexplained post-acute infection syndromes. Nat Med. 2022;28(5):911\u201323.","journal-title":"Nat Med"},{"key":"8162_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fped.2019.00012","volume":"7","author":"L Chu","year":"2019","unstructured":"Chu L, Valencia IJ, Garvert DW, Montoya JG. Onset Patterns and Course of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome. Front Pediatr. 2019;7:12.","journal-title":"Front Pediatr"},{"issue":"1","key":"8162_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12920-017-0248-3","volume":"10","author":"WC de Vega","year":"2017","unstructured":"de Vega WC, Herrera S, Vernon SD, McGowan PO. Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). BMC Med Genomics. 2017;10(1):11.","journal-title":"BMC Med Genomics"},{"issue":"12","key":"8162_CR13","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1080\/15592294.2018.1549769","volume":"13","author":"S Herrera","year":"2018","unstructured":"Herrera S, de Vega WC, Ashbrook D, Vernon SD, McGowan PO. Genome-epigenome interactions associated with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome. Epigenetics. 2018;13(12):1174\u201390.","journal-title":"Epigenetics"},{"issue":"1","key":"8162_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13148-020-00960-z","volume":"12","author":"AM Helliwell","year":"2020","unstructured":"Helliwell AM, Sweetman EC, Stockwell PA, Edgar CD, Chatterjee A, Tate WP. Changes in DNA methylation profiles of myalgic encephalomyelitis\/chronic fatigue syndrome patients reflect systemic dysfunctions. Clin Epigenetics. 2020;12(1):167.","journal-title":"Clin Epigenetics"},{"issue":"7","key":"8162_CR15","doi-asserted-by":"publisher","first-page":"e0201066","DOI":"10.1371\/journal.pone.0201066","volume":"13","author":"MS Trivedi","year":"2018","unstructured":"Trivedi MS, Oltra E, Sarria L, Rose N, Beljanski V, Fletcher MA, et al. Identification of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome-associated DNA methylation patterns. PLoS ONE. 2018;13(7):e0201066.","journal-title":"PLoS ONE"},{"issue":"4","key":"8162_CR16","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.clinthera.2019.02.012","volume":"41","author":"E Almenar-P\u00e9rez","year":"2019","unstructured":"Almenar-P\u00e9rez E, Ovejero T, S\u00e1nchez-Fito T, Espejo JA, Nathanson L, Oltra E. Epigenetic Components of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation. Clin Ther. 2019;41(4):675\u201398.","journal-title":"Clin Ther"},{"issue":"3","key":"8162_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/bcpt.12721","volume":"121","author":"SAS Langie","year":"2017","unstructured":"Langie SAS, Moisse M, Declerck K, Koppen G, Godderis L, Vanden Berghe W, et al. Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification. Basic Clin Pharmacol Toxicol. 2017;121(3):93\u2013101.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"8162_CR18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/ajmg.b.32278","volume":"168b","author":"AK Smith","year":"2015","unstructured":"Smith AK, Kilaru V, Klengel T, Mercer KB, Bradley B, Conneely KN, et al. DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain. Am J Med Genet B Neuropsychiatr Genet. 2015;168b(1):36\u201344.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1","key":"8162_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41398-019-0376-y","volume":"9","author":"PR Braun","year":"2019","unstructured":"Braun PR, Han S, Hing B, Nagahama Y, Gaul LN, Heinzman JT, et al. Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals. Transl Psychiatry. 2019;9(1):47.","journal-title":"Transl Psychiatry"},{"issue":"24","key":"8162_CR20","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","volume":"25","author":"JE Ware","year":"2000","unstructured":"Ware JE. Jr. SF-36 health survey update. Spine (Phila Pa 1976). 2000;25(24):3130\u20139.","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"8162_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","volume":"39","author":"EM Smets","year":"1995","unstructured":"Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39(3):315\u201325.","journal-title":"J Psychosom Res"},{"key":"8162_CR22","doi-asserted-by":"crossref","unstructured":"Jason LA, Sunnquist M, Brown A, Furst J, Cid M, Farietta J, et al. Factor analysis of the depaul symptom questionnaire: identifying core domains. J Neurol Neurobiol. 2015;1(4).","DOI":"10.16966\/2379-7150.114"},{"issue":"1","key":"8162_CR23","doi-asserted-by":"publisher","first-page":"e12615","DOI":"10.2196\/12615","volume":"2","author":"S Groppell","year":"2019","unstructured":"Groppell S, Soto-Ruiz KM, Flores B, Dawkins W, Smith I, Eagleman DM, et al. A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study. JMIR Aging. 2019;2(1):e12615.","journal-title":"JMIR Aging"},{"issue":"7","key":"8162_CR24","doi-asserted-by":"publisher","first-page":"e0179352","DOI":"10.1371\/journal.pone.0179352","volume":"12","author":"S Yang","year":"2017","unstructured":"Yang S, Flores B, Magal R, Harris K, Gross J, Ewbank A, et al. Diagnostic accuracy of tablet-based software for the detection of concussion. PLoS ONE. 2017;12(7):e0179352.","journal-title":"PLoS ONE"},{"key":"8162_CR25","doi-asserted-by":"crossref","unstructured":"Azimi G, Elremaly W, Elbakry M, Franco A, Godbout C, Moreau A. Circulating FGF-21 as a disease-modifying factor associated with distinct symptoms and cognitive profiles in myalgic encephalomyelitis and fibromyalgia. Int J Mol Sci. 2025;26(16).","DOI":"10.3390\/ijms26167670"},{"issue":"3","key":"8162_CR26","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1093\/bioinformatics\/btt684","volume":"30","author":"TJ Morris","year":"2014","unstructured":"Morris TJ, Butcher LM, Feber A, Teschendorff AE, Chakravarthy AR, Wojdacz TK, et al. ChAMP: 450k Chip Analysis Methylation Pipeline. Bioinformatics. 2014;30(3):428\u201330.","journal-title":"Bioinformatics"},{"issue":"10","key":"8162_CR27","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","volume":"30","author":"MJ Aryee","year":"2014","unstructured":"Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30(10):1363\u20139.","journal-title":"Bioinformatics"},{"issue":"4","key":"8162_CR28","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","volume":"33","author":"J-P Fortin","year":"2017","unstructured":"Fortin J-P, Triche TJ Jr, Hansen KDJB. Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi. Bioinformatics. 2017;33(4):558\u201360.","journal-title":"Bioinformatics"},{"issue":"4","key":"8162_CR29","first-page":"e22","volume":"45","author":"W Zhou","year":"2017","unstructured":"Zhou W, Laird PW, Shen H. Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes. Nucleic Acids Res. 2017;45(4):e22.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"8162_CR30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","volume":"29","author":"AE Teschendorff","year":"2013","unstructured":"Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D, et al. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics. 2013;29(2):189\u201396.","journal-title":"Bioinformatics"},{"key":"8162_CR31","unstructured":"Leek J, Johnson W, Parker H, Fertig E, Jaffe A, Storey J, et al. sva: Surrogate Variable Analysis. R package version 3.24. 4. 2017."},{"issue":"1","key":"8162_CR32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson WE, Li C, Rabinovic AJB. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8(1):118\u201327.","journal-title":"Biostatistics"},{"key":"8162_CR33","doi-asserted-by":"publisher","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004;3:Article3.","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"18","key":"8162_CR34","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.1093\/bioinformatics\/bth449","volume":"20","author":"JM Wettenhall","year":"2004","unstructured":"Wettenhall JM, Smyth GK. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics. 2004;20(18):3705\u20136.","journal-title":"Bioinformatics"},{"issue":"1","key":"8162_CR35","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/ije\/dyr238","volume":"41","author":"AE Jaffe","year":"2012","unstructured":"Jaffe AE, Murakami P, Lee H, Leek JT, Fallin MD, Feinberg AP, et al. Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol. 2012;41(1):200\u20139.","journal-title":"Int J Epidemiol"},{"key":"8162_CR36","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/1471-2105-11-587","volume":"11","author":"P Du","year":"2010","unstructured":"Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, Hou L, et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"8162_CR37","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13148-022-01403-7","volume":"14","author":"R Grolaux","year":"2022","unstructured":"Grolaux R, Hardy A, Olsen C, Van Dooren S, Smits G, Defrance M. Identification of differentially methylated regions in rare diseases from a single-patient perspective. Clin Epigenetics. 2022;14(1):174.","journal-title":"Clin Epigenetics"},{"issue":"3","key":"8162_CR38","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1158\/1055-9965.EPI-14-0853","volume":"24","author":"YB Shvetsov","year":"2015","unstructured":"Shvetsov YB, Song MA, Cai Q, Tiirikainen M, Xiang YB, Shu XO, et al. Intraindividual variation and short-term temporal trend in DNA methylation of human blood. Cancer Epidemiol Biomarkers Prev. 2015;24(3):490\u20137.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"8162_CR39","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10529-011-0813-3","volume":"34","author":"X Luo","year":"2012","unstructured":"Luo X, Zhang J, Wang H, Du Y, Yang L, Zheng F, et al. PolyA RT-PCR-based quantification of microRNA by using universal TaqMan probe. Biotechnol Lett. 2012;34(4):627\u201333.","journal-title":"Biotechnol Lett"},{"issue":"4","key":"8162_CR40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"7","key":"8162_CR41","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s00125-013-2901-5","volume":"56","author":"W Mandemakers","year":"2013","unstructured":"Mandemakers W, Abuhatzira L, Xu H, Caromile LA, H\u00e9bert SS, Snellinx A, et al. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 \u03b2: identification of miR-153 target genes with functions related to IA-2\u03b2 in pancreas and brain. Diabetologia. 2013;56(7):1547\u201356.","journal-title":"Diabetologia"},{"key":"8162_CR42","doi-asserted-by":"publisher","first-page":"122371","DOI":"10.1016\/j.lfs.2023.122371","volume":"338","author":"B Zhang","year":"2024","unstructured":"Zhang B, Li W, Cao J, Zhou Y, Yuan X. Prohibitin 2: A key regulator of cell function. Life Sci. 2024;338:122371.","journal-title":"Life Sci"},{"key":"8162_CR43","doi-asserted-by":"publisher","first-page":"714228","DOI":"10.3389\/fgene.2021.714228","volume":"12","author":"M Belser","year":"2021","unstructured":"Belser M, Walker DW. Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases. Front Genet. 2021;12:714228.","journal-title":"Front Genet"},{"issue":"1","key":"8162_CR44","doi-asserted-by":"publisher","first-page":"9115","DOI":"10.1038\/s41598-017-09481-x","volume":"7","author":"M Lach\u00e9n-Montes","year":"2017","unstructured":"Lach\u00e9n-Montes M, Gonz\u00e1lez-Morales A, Zelaya MV, P\u00e9rez-Valderrama E, Aus\u00edn K, Ferrer I, et al. Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer\u2019s disease progression. Sci Rep. 2017;7(1):9115.","journal-title":"Sci Rep"},{"key":"8162_CR45","doi-asserted-by":"publisher","first-page":"9233749","DOI":"10.1155\/2022\/9233749","volume":"2022","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wu J, Jin W, Shen M, Yin S, Lai X, et al. Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson\u2019s Disease Model. Oxid Med Cell Longev. 2022;2022:9233749.","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"8162_CR46","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.2337\/db13-0152","volume":"62","author":"S Supale","year":"2013","unstructured":"Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, et al. Loss of prohibitin induces mitochondrial damages altering \u03b2-cell function and survival and is responsible for gradual diabetes development. Diabetes. 2013;62(10):3488\u201399.","journal-title":"Diabetes"},{"key":"8162_CR47","doi-asserted-by":"crossref","unstructured":"Qi A, Lamont L, Liu E, Murray SD, Meng X, Yang S. Essential protein PHB2 and its regulatory mechanisms in cancer. Cells. 2023;12(8).","DOI":"10.3390\/cells12081211"},{"issue":"1","key":"8162_CR48","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/imr.12059","volume":"253","author":"Y Bronevetsky","year":"2013","unstructured":"Bronevetsky Y, Ansel KM. Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev. 2013;253(1):304\u201316.","journal-title":"Immunol Rev"},{"issue":"9","key":"8162_CR49","doi-asserted-by":"publisher","first-page":"15592","DOI":"10.3390\/ijms150915592","volume":"15","author":"D Campos-Melo","year":"2014","unstructured":"Campos-Melo D, Droppelmann CA, Volkening K, Strong MJ. Comprehensive luciferase-based reporter gene assay reveals previously masked up-regulatory effects of miRNAs. Int J Mol Sci. 2014;15(9):15592\u2013602.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"8162_CR50","first-page":"4390","volume":"45","author":"I Mendizabal","year":"2017","unstructured":"Mendizabal I, Zeng J, Keller TE, Yi SV. Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation. Nucleic Acids Res. 2017;45(8):4390\u2013400.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"8162_CR51","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13148-022-01382-9","volume":"14","author":"Q Wang","year":"2022","unstructured":"Wang Q, Xiong F, Wu G, Liu W, Chen J, Wang B, et al. Gene body methylation in cancer: molecular mechanisms and clinical applications. Clin Epigenetics. 2022;14(1):154.","journal-title":"Clin Epigenetics"},{"issue":"4","key":"8162_CR52","doi-asserted-by":"publisher","first-page":"e0176067","DOI":"10.1371\/journal.pone.0176067","volume":"12","author":"G Navarro","year":"2017","unstructured":"Navarro G, Mart\u00ednez-Pinilla E, S\u00e1nchez-Melgar A, Ortiz R, No\u00e9 V, Mart\u00edn M, et al. A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression. PLoS ONE. 2017;12(4):e0176067.","journal-title":"PLoS ONE"},{"issue":"4","key":"8162_CR53","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/acn3.745","volume":"6","author":"EL van der Ende","year":"2019","unstructured":"van der Ende EL, Meeter LH, Stingl C, van Rooij JGJ, Stoop MP, Nijholt DAT, et al. Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics. Ann Clin Transl Neurol. 2019;6(4):698\u2013707.","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"8162_CR54","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41398-020-01060-5","volume":"10","author":"J Linthorst","year":"2020","unstructured":"Linthorst J, Meert W, Hestand MS, Korlach J, Vermeesch JR, Reinders MJT, et al. Extreme enrichment of VNTR-associated polymorphicity in human subtelomeres: genes with most VNTRs are predominantly expressed in the brain. Transl Psychiatry. 2020;10(1):369.","journal-title":"Transl Psychiatry"},{"issue":"1","key":"8162_CR55","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41531-022-00355-2","volume":"8","author":"J Kochmanski","year":"2022","unstructured":"Kochmanski J, Kuhn NC, Bernstein AI. Parkinson\u2019s disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2\u03b2), and NR4A2 (NURR1) in cortical neurons. NPJ Parkinsons Dis. 2022;8(1):120.","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"8162_CR56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13024-024-00705-z","volume":"19","author":"S Mravinacov\u00e1","year":"2024","unstructured":"Mravinacov\u00e1 S, Alanko V, Bergstr\u00f6m S, Bridel C, Pijnenburg Y, Hagman G, et al. CSF protein ratios with enhanced potential to reflect Alzheimer\u2019s disease pathology and neurodegeneration. Mol Neurodegener. 2024;19(1):15.","journal-title":"Mol Neurodegener"},{"issue":"1","key":"8162_CR57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00592-015-0750-z","volume":"53","author":"T Cai","year":"2016","unstructured":"Cai T, Notkins AL. Pathophysiologic changes in IA-2\/IA-2\u03b2 null mice are secondary to alterations in the secretion of hormones and neurotransmitters. Acta Diabetol. 2016;53(1):7\u201312.","journal-title":"Acta Diabetol"},{"issue":"10","key":"8162_CR58","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.tem.2010.06.003","volume":"21","author":"J Suckale","year":"2010","unstructured":"Suckale J, Solimena M. The insulin secretory granule as a signaling hub. Trends Endocrinol Metab. 2010;21(10):599\u2013609.","journal-title":"Trends Endocrinol Metab"},{"issue":"9","key":"8162_CR59","first-page":"992","volume":"52","author":"PC Shen","year":"2022","unstructured":"Shen PC, Wang YF, Chang HC, Huang WY, Lo CH, Su YF, et al. Developing a novel DNA methylation risk score for survival and identification of prognostic gene mutations in endometrial cancer: a study based on TCGA data. Jpn J Clin Oncol. 2022;52(9):992\u20131000.","journal-title":"Jpn J Clin Oncol"},{"issue":"6","key":"8162_CR60","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1080\/15592294.2021.1950991","volume":"17","author":"AG Izquierdo","year":"2022","unstructured":"Izquierdo AG, Boughanem H, Diaz-Lagares A, Arranz-Salas I, Esteller M, Tinahones FJ, et al. DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer. Epigenetics. 2022;17(6):665\u201376.","journal-title":"Epigenetics"},{"issue":"16","key":"8162_CR61","doi-asserted-by":"publisher","first-page":"5524","DOI":"10.1002\/cam4.4078","volume":"10","author":"J Yin","year":"2021","unstructured":"Yin J, Guo Y. HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2. Cancer Med. 2021;10(16):5524\u201333.","journal-title":"Cancer Med"},{"issue":"1","key":"8162_CR62","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s40478-021-01177-8","volume":"9","author":"L Zhang","year":"2021","unstructured":"Zhang L, Young JI, Gomez L, Silva TC, Schmidt MA, Cai J, et al. Sex-specific DNA methylation differences in Alzheimer\u2019s disease pathology. Acta Neuropathol Commun. 2021;9(1):77.","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"8162_CR63","doi-asserted-by":"publisher","first-page":"5022","DOI":"10.1038\/s41598-021-83185-1","volume":"11","author":"YC Chen","year":"2021","unstructured":"Chen YC, Tsai YH, Wang CC, Liu SF, Chen TW, Fang WF, et al. Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes. Sci Rep. 2021;11(1):5022.","journal-title":"Sci Rep"},{"key":"8162_CR64","doi-asserted-by":"crossref","unstructured":"Honkova K, Rossnerova A, Chvojkova I, Milcova A, Margaryan H, Pastorkova A, et al. Genome-wide DNA methylation in policemen working in cities differing by major sources of air pollution. Int J Mol Sci. 2022;23(3).","DOI":"10.3390\/ijms23031666"},{"issue":"10","key":"8162_CR65","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1007\/s00125-015-3683-8","volume":"58","author":"H Xu","year":"2015","unstructured":"Xu H, Abuhatzira L, Carmona GN, Vadrevu S, Satin LS, Notkins AL. The Ia-2\u03b2 intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice. Diabetologia. 2015;58(10):2298\u2013306.","journal-title":"Diabetologia"},{"key":"8162_CR66","doi-asserted-by":"publisher","first-page":"985897","DOI":"10.3389\/fonc.2022.985897","volume":"12","author":"S Yousefnia","year":"2022","unstructured":"Yousefnia S. A comprehensive review on miR-153: Mechanistic and controversial roles of miR-153 in tumorigenicity of cancer cells. Front Oncol. 2022;12:985897.","journal-title":"Front Oncol"},{"key":"8162_CR67","doi-asserted-by":"publisher","first-page":"1271404","DOI":"10.3389\/fgene.2024.1271404","volume":"15","author":"S Amber","year":"2024","unstructured":"Amber S, Zahid S. An in silico approach to identify potential downstream targets of miR-153 involved in Alzheimer\u2019s disease. Front Genet. 2024;15:1271404.","journal-title":"Front Genet"},{"key":"8162_CR68","doi-asserted-by":"publisher","first-page":"738140","DOI":"10.3389\/fphys.2021.738140","volume":"12","author":"I Duroux-Richard","year":"2021","unstructured":"Duroux-Richard I, Apparailly F, Khoury M. Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation. Front Physiol. 2021;12:738140.","journal-title":"Front Physiol"},{"key":"8162_CR69","doi-asserted-by":"publisher","first-page":"663322","DOI":"10.3389\/fphar.2021.663322","volume":"12","author":"GQ Zhang","year":"2021","unstructured":"Zhang GQ, Wang SQ, Chen Y, Fu LY, Xu YN, Li L, et al. MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases. Front Pharmacol. 2021;12:663322.","journal-title":"Front Pharmacol"},{"issue":"12","key":"8162_CR70","doi-asserted-by":"publisher","first-page":"e0143969","DOI":"10.1371\/journal.pone.0143969","volume":"10","author":"KS Patil","year":"2015","unstructured":"Patil KS, Basak I, Pal R, Ho HP, Alves G, Chang EJ, et al. A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells. PLoS ONE. 2015;10(12):e0143969.","journal-title":"PLoS ONE"},{"issue":"2","key":"8162_CR71","doi-asserted-by":"publisher","first-page":"4493","DOI":"10.1080\/21655979.2022.2033409","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, Yang Y, Zhou C, Zhu R, Xiao X, Zhou B, et al. LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p\/alpha-synuclein axis in Parkinson\u2019s disease. Bioengineered. 2022;13(2):4493\u2013516.","journal-title":"Bioengineered"},{"key":"8162_CR72","doi-asserted-by":"publisher","first-page":"109900","DOI":"10.1016\/j.cbi.2022.109900","volume":"358","author":"Y Li","year":"2022","unstructured":"Li Y, Peng B, Li Y, Huang A, Peng Y, Yu Q, et al. MiR-203a-3p\/153-3p improves cognitive impairments induced by ischemia\/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke. Chem Biol Interact. 2022;358:109900.","journal-title":"Chem Biol Interact"},{"issue":"21","key":"8162_CR73","first-page":"13304","volume":"16","author":"Q Gao","year":"2024","unstructured":"Gao Q, Li X, Huang T, Gao L, Wang S, Deng Y, et al. Angiotensin-(1\u20137) relieves behavioral defects and \u03b1-synuclein expression through NEAT1\/miR-153-3p axis in Parkinson\u2019s disease. Aging. 2024;16(21):13304\u201322.","journal-title":"Aging"},{"issue":"1","key":"8162_CR74","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12964-020-00551-8","volume":"18","author":"ML Yan","year":"2020","unstructured":"Yan ML, Zhang S, Zhao HM, Xia SN, Jin Z, Xu Y, et al. MicroRNA-153 impairs presynaptic plasticity by blocking vesicle release following chronic brain hypoperfusion. Cell Commun Signal. 2020;18(1):57.","journal-title":"Cell Commun Signal"},{"key":"8162_CR75","doi-asserted-by":"crossref","unstructured":"Zhao M, Wang W, Lu Y, Wang N, Kong D, Shan L. MicroRNA\u2013153 attenuates hypoxia\u2013induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3. Mol Med Rep. 2021;23(3).","DOI":"10.3892\/mmr.2021.11833"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08162-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08162-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08162-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:08:24Z","timestamp":1781064504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08162-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8162"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08162-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"2 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of CHU Sainte-Justine (protocol #4047). Informed consent was obtained from all participants involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"AM is the Director of the Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis (ICanCME) Research Network, a national research network funded by The Canadian Institutes of Health Research (grant MNC\u2013196095 and MNC\u2013196095 to A.M.) and a member of the Scientific Advisory Board of the Open Medicine Foundation (USA).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"752"}}