{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:56:47Z","timestamp":1792727807538,"version":"4.5.0"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Host dependency factors (HDF) are essential for viral replication and are promising targets for broad-spectrum antivirals. However, most work has focused on individual viruses or individual data types, limiting our understanding of shared host mechanisms across viruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed a pan\u2013viral framework that integrates multi\u2013omics data\u2013including genome-wide perturbation screens, single\u2013cell transcriptomes and viral interactomes\u2013and combines graph\u2013based learning with classical machine\u2013learning models to prioritize HDF for four RNA viruses (SARS-CoV\u20132, influenza A virus, dengue virus and Zika virus).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across viruses, the framework achieved high discrimination, with area under the receiver operating characteristic curve (ROC\u2013AUC) greater than 0.90 on benchmark datasets, and identified a conserved signature of 118 genes shared by all four viruses and 427 genes shared by at least three. These genes converge on recurrent host programmes such as clathrin\u2013mediated entry and endomembrane trafficking, nuclear transport, RNA processing and stress granules, and proteostasis and ubiquitin\u2013proteasome signalling. The pan\u2013viral signature generalizes beyond the training set, as genes shared by three or more viruses are strongly enriched among top\u2013ranked Ebola virus candidates. We further provide a prioritized shortlist and an experimental validation roadmap to guide follow\u2013up perturbation studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our integrative multi-omics and machine-learning approach outlines a prediction-based, data-driven map of pan-viral host liabilities and highlights tractable opportunities for host-directed therapy against diverse RNA viruses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-026-08197-9","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:03:52Z","timestamp":1777734232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A pan-viral map of host dependency factors from multi-omics integration and machine learning across influenza A, SARS-CoV-2, Zika, and dengue viruses"],"prefix":"10.1186","volume":"24","author":[{"given":"Mohadeseh","family":"Naseri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Hiemisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Oswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-7667","authenticated-orcid":false,"given":"Rainer","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"8197_CR1","doi-asserted-by":"publisher","first-page":"110042","DOI":"10.1016\/j.virol.2024.110042","volume":"594","author":"S Li","year":"2024","unstructured":"Li S, Li H, Lian R, Xie J, Feng R. New perspective of small-molecule antiviral drugs development for RNA viruses. Virology [Internet]. 2024;594:110042. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0042682224000631. 2025 Oct 7.","journal-title":"Virology"},{"issue":"1","key":"8197_CR2","first-page":"1","volume":"15","author":"J Hou","year":"2024","unstructured":"Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang SZheng N, et al. Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Nat Commun [Internet]. 2024;15(1):1\u201314. Available from: https:\/\/www.nature.com\/articles\/s41467-023-44175-1. 2025 Oct 12.","journal-title":"Nat Commun"},{"issue":"1","key":"8197_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41467-019-13965-x","volume":"11","author":"B Li","year":"2020","unstructured":"Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, et al. Genome-wide CRISPR screen identifies host dependency factors for influenza a virus infection. Nat Commun. 2020;11(1):11. https:\/\/doi.org\/10.1038\/s41467-019-13965-x.","journal-title":"Nat Commun"},{"key":"8197_CR4","unstructured":"Dengue [Internet]. [https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue. 2025 Oct 12]."},{"key":"8197_CR5","unstructured":"Zika virus [Internet]. [https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/zika-virus. 2025 Oct 12]."},{"key":"8197_CR6","unstructured":"Ebola disease [Internet]. [https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ebola-disease. 2025 Oct 12]."},{"key":"8197_CR7","doi-asserted-by":"publisher","first-page":"935933","DOI":"10.3389\/fviro.2022.935933","volume":"2","author":"R Badia","year":"2022","unstructured":"Badia R, Garcia-Vidal E, Ballana E. Viral-host dependency factors as therapeutic targets to overcome antiviral drug-resistance: a focus on innate immune modulation. Front Virol [Internet]. 2022;2:935933. Available from: https:\/\/www.frontiersin.org. 2025 Oct 12.","journal-title":"Front Virol"},{"key":"8197_CR8","doi-asserted-by":"publisher","first-page":"102228","DOI":"10.1016\/j.mib.2022.102228","volume":"71","author":"J Adderley","year":"2023","unstructured":"Adderley J, Grau GE. Host-directed therapies for malaria: possible applications and lessons from other indications. Curr Opin Microbiol [Internet]. 2023;71:102228. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1369527422001126. 2025 Oct 7.","journal-title":"Curr Opin Microbiol"},{"key":"8197_CR9","doi-asserted-by":"publisher","unstructured":"Chitalia VC, Munawar AH. A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals. J Transl Med. 2020;18], 18, 181 [390\u2013 [Internet]. Available from: 1). https:\/\/doi.org\/10.1186\/s12967-020-02476-9. 2026 Feb 25.","DOI":"10.1186\/s12967-020-02476-9"},{"issue":"1","key":"8197_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrd.2017.162","volume":"17","author":"SHE Kaufmann","year":"2018","unstructured":"Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov [Internet]. 2018;17(1):35\u201356. Available from: https:\/\/doi.org\/10.1038\/nrd.2017.162.","journal-title":"Nat Rev Drug Discov"},{"key":"8197_CR11","doi-asserted-by":"crossref","unstructured":"Kumar N, Sharma S, Kumar R, Tripathi BN, Barua S, Ly H, et al. Host-directed antiviral therapy. Clin Microbiol Rev [Internet]. 2020;33(3):e00168\u201319. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7227448\/. 2026 Feb 25.","DOI":"10.1128\/CMR.00168-19"},{"issue":"8","key":"8197_CR12","doi-asserted-by":"publisher","first-page":"110475","DOI":"10.1016\/j.isci.2024.110475","volume":"27","author":"M Sakai","year":"2024","unstructured":"Sakai M, Masuda Y, Tarumoto Y, Aihara N, Tsunoda Y, Iwata M, et al. Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection. iScience [Internet]. 2024;27(8):110475. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2589004224017000. 2025 Oct 7.","journal-title":"iScience"},{"issue":"8","key":"8197_CR13","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41588-022-01110-2","volume":"54","author":"A Rebendenne","year":"2022","unstructured":"Rebendenne A, Roy P, Bonaventure B, Chaves Valad\u00e3o AL, Desmarets L, Arnaud-Arnould M, et al. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nat Genet. 2022;54(8):1090\u2013102. https:\/\/doi.org\/10.1038\/s41588-022-01110-2.","journal-title":"Nat Genet"},{"issue":"1","key":"8197_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-79033-3","volume":"10","author":"N Parkinson","year":"2020","unstructured":"Parkinson N, Rodgers N, Head Fourman M, Wang B, Zechner M, Swets MC, et al. Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19. Sci Rep [Internet]. 2020;10(1):1\u201312. Available from: https:\/\/www.nature.com\/articles\/s41598-020-79033-3. 2025 Sep 11.","journal-title":"Sci Rep"},{"issue":"5","key":"8197_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1128\/jvi.01857-23","volume":"98","author":"A Maes","year":"2024","unstructured":"Maes A, Botzki A, Mathys J, Impens F, Saelens X. Systematic review and meta-analysis of genome-wide pooled CRISPR screens to identify host factors involved in influenza a virus infection. J Virol. 2024;98(5):98. https:\/\/doi.org\/10.1128\/jvi.01857-23.","journal-title":"J Virol"},{"key":"8197_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fmicb.2023.1193320","volume":"14","author":"MA Kelch","year":"2023","unstructured":"Kelch MA, Vera-Guapi A, Beder T, Oswald M, Hiemisch A, Beil N, et al. Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies \u03b2-catenin\/CBP inhibitor PRI-724 as a potent antiviral. Front MicrobiolFront. Microbiol. 2023;14:14. https:\/\/doi.org\/10.3389\/fmicb.2023.1193320.","journal-title":"Front MicrobiolFront. Microbiol"},{"issue":"1","key":"8197_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L. Random forests. Mach Learn. 2001;45(1):5\u201332. Available from: https:\/\/doi.org\/10.1023\/A:1010933404324. 2025 Oct 13.","journal-title":"Mach Learn"},{"key":"8197_CR18","doi-asserted-by":"crossref","unstructured":"Chen T, Guestrin C. Xgboost: a scalable tree boosting system. Proc ACM SIGKDD Int Conf Knowl Discov Data Min [Internet]. 2016 [cited 2025 Oct 13];13-17-2016:785\u201394. https:\/\/arxiv.org\/pdf\/1603.02754.","DOI":"10.1145\/2939672.2939785"},{"issue":"12","key":"8197_CR19","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","volume":"15","author":"W Li","year":"2014","unstructured":"Li W, Xu H, Xiao T, Cong L, Love MI, Zhang F, et al. MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens. Genome Biol. 2014;15(12):554. https:\/\/doi.org\/10.1186\/s13059-014-0554-4.","journal-title":"Genome Biol"},{"issue":"51","key":"8197_CR20","doi-asserted-by":"publisher","first-page":"20380","DOI":"10.1073\/pnas.0810485105","volume":"105","author":"B Luo","year":"2008","unstructured":"Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, et al. Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci USA. 2008;105(51):20380\u201385. https:\/\/doi.org\/10.1073\/pnas.0810485105.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"8197_CR21","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nmeth1089","volume":"4","author":"R K\u00f6nig","year":"2007","unstructured":"K\u00f6nig R, Chiang CY, Tu BP, Yan SF, DeJesus PD, Romero A, et al. A probability-based approach for the analysis of large-scale RNAi screens. Nat Methods. 2007;4(10):847\u201349. https:\/\/doi.org\/10.1038\/nmeth1089.","journal-title":"Nat Methods"},{"issue":"2","key":"8197_CR22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol [Internet]. 2024;42(2):293\u2013304. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/37231261\/. 2025 Oct 13.","journal-title":"Nat Biotechnol"},{"issue":"11","key":"8197_CR23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/14786440109462720","volume":"2","author":"FRSKP Pearson","year":"1901","unstructured":"Pearson FRSKP. LIII. On lines and planes of closest fit to systems of points in space. London, Edinburgh, Dublin Lond, Edinburgh Dublin Phil Mag J Sci [Internet]. 1901;2(11):559\u201372. Available from: https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14786440109462720%3Fcasa_token%3DcsKufH62bkkAAAAA:Ndb5zioz-awGF7ocKeQELVUt6uee2hh-dwEfvEPeE-EebBwjEMy9gpCgdVje9prgn14xsjAuUKuX%26hl=en%26sa=T%26oi=ucasa%26ct=ucasa%26ei=QPrsaJuKD6SHieoP6KSBoQ4%26scisig=AAZF9b88ySA5pIhWXIoZdXcvB17z. 2025 Oct 13.","journal-title":"Lond, Edinburgh Dublin Phil Mag J Sci"},{"issue":"29","key":"8197_CR24","doi-asserted-by":"publisher","first-page":"861","DOI":"10.21105\/joss.00861","volume":"3","author":"L McInnes","year":"2018","unstructured":"McInnes L, Healy J, Saul N, Gro\u00dfberger L. UMAP: uniform manifold Approximation and projection for dimension reduction. 2018, Available from: J Educ Chang Open Source Softw. 2018;3(29):861. https:\/\/doi.org\/10.21105\/joss.00861.","journal-title":"J Educ Chang Open Source Softw"},{"issue":"6","key":"8197_CR25","doi-asserted-by":"publisher","first-page":"100498","DOI":"10.1016\/j.crmeth.2023.100498","volume":"3","author":"S Morabito","year":"2023","unstructured":"Morabito S, Reese F, Rahimzadeh N, Miyoshi E, Swarup V. hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell Rep Methods [Internet]. 2023;3(6):100498. Available from: https:\/\/doi.org\/10.1016\/j.crmeth.2023.100498.","journal-title":"Cell Rep Methods"},{"key":"8197_CR26","doi-asserted-by":"crossref","unstructured":"Verschueren E, Von Dollen J, Cimermancic P, Gulbahce N, Sali A, Krogan NJ. Scoring large-scale affinity purification mass spectrometry datasets with MiST. CP Bioinf [Internet]. 2015;49(1):8.19.1. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4378866\/. 2025 Oct 13.","DOI":"10.1002\/0471250953.bi0819s49"},{"key":"8197_CR27","doi-asserted-by":"crossref","unstructured":"Choi H, Liu G, Mellacheruvu D, Tyers M, Gingras AC, Nesvizhskii AI. Analyzing protein-protein interactions from affinity purification-mass spectrometry data with SAINT. Curr protoc bioinformatics [Internet]. 2012. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3446209\/. 2025 Oct 13.","DOI":"10.1002\/0471250953.bi0815s39"},{"issue":"4","key":"8197_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nargab\/lqab110","volume":"3","author":"T Beder","year":"2021","unstructured":"Beder T, Aromolaran O, D\u00f6nitz J, Tapanelli S, Adedeji EO, Adebiyi E, et al. Identifying essential genes across eukaryotes by machine learning. NAR Genomics Bioinf. 2021;3(4):1\u201313. https:\/\/doi.org\/10.1093\/nargab\/lqab110.","journal-title":"NAR Genomics Bioinf"},{"key":"8197_CR29","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.csbj.2020.02.022","volume":"18","author":"O Aromolaran","year":"2020","unstructured":"Aromolaran O, Beder T, Oswald M, Oyelade J, Adebiyi E, Koenig R. Essential gene prediction in drosophila melanogaster using machine learning approaches based on sequence and functional features. Comput Struct Biotechnol J [Internet]. 2020;18:612\u201321. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2001037019305628?via%3Dihub. 2025 Sep 24.","journal-title":"Comput Struct Biotechnol J"},{"key":"8197_CR30","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.1016\/j.csbj.2021.08.010","volume":"19","author":"O Aromolaran","year":"2021","unstructured":"Aromolaran O, Beder T, Adedeji E, Ajamma Y, Oyelade J, Adebiyi E, et al. Predicting host dependency factors of pathogens in drosophila melanogaster using machine learning. Comput Struct Biotechnol J [Internet]. 2021;19:4581\u201392. Available from: https:\/\/doi.org\/10.1016\/j.csbj.2021.08.010.","journal-title":"Comput Struct Biotechnol J"},{"issue":"4","key":"8197_CR31","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1093\/bioinformatics\/bti037","volume":"21","author":"D Charif","year":"2005","unstructured":"Charif D, Thioulouse J, Lobry JR, Perri\u00e8re G. Online synonymous codon usage analyses with the ade4 and seqinR packages. Bioinformatics [Internet]. 2005;21(4):545\u201347. Available from: https:\/\/doi.org\/10.1093\/bioinformatics\/bti037. 2025 Oct 13.","journal-title":"Bioinformatics"},{"issue":"11","key":"8197_CR32","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1093\/bioinformatics\/btv042","volume":"31","author":"N Xiao","year":"2015","unstructured":"Xiao N, Cao DS, Zhu MF, Xu Q-S. Protr\/ProtrWeb: R package and web server for generating various numerical representation schemes of protein sequences. Bioinformatics [Internet]. 2015;31(11):1857\u201359. Available from: https:\/\/doi.org\/10.1093\/bioinformatics\/btv042. 2025 Oct 13.","journal-title":"Bioinformatics"},{"key":"8197_CR33","doi-asserted-by":"crossref","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res [Internet]. 2023;51(D1):D638\u201346. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36370105\/. 2025 Dec 2.","DOI":"10.1093\/nar\/gkac1000"},{"key":"8197_CR34","doi-asserted-by":"publisher","unstructured":"H\u00f6rhold F, Eisel D, Oswald M, Kolte A, R\u00f6ll D, Osen W, et al. Reprogramming of macrophages employing gene regulatory and metabolic network models. PLoS Comput Biol [Internet]. 2020;16(2):e1007657. Available from: https:\/\/doi.org\/10.1371\/journal.pcbi.1007657. 2025 Nov 3.","DOI":"10.1371\/journal.pcbi.1007657"},{"issue":"1","key":"8197_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-10-22","volume":"10","author":"D Smedley","year":"2009","unstructured":"Smedley D, Haider S, Ballester B, Holland R, London D, Thorisson G, et al. BioMart \u2013 biological queries made easy. BMC Genomics [Internet]. 2009;10(1):1\u201312. Available from: https:\/\/doi.org\/10.1186\/1471-2164-10-22. 2025 Oct 13.","journal-title":"BMC Genomics"},{"key":"8197_CR36","doi-asserted-by":"publisher","unstructured":"Pruitt KD. NCBI Reference sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res [Internet]. 2004;33(Database issue):D501\u20134. Available from: https:\/\/doi.org\/10.1093\/nar\/gki025. 2025 Oct 13.","DOI":"10.1093\/nar\/gki025"},{"issue":"17","key":"8197_CR37","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res [Internet]. 1997;25(17):3389\u2013402. Available from: https:\/\/doi.org\/10.1093\/nar\/25.17.3389. 2025 Oct 13.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"8197_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/bib\/bbac456","volume":"23","author":"V Ravindran","year":"2022","unstructured":"Ravindran V, Wagoner J, Athanasiadis P, Den Hartigh AB, Sidorova JM, Ianevski A, et al. Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2\u2013host protein\u2013protein interaction network. Briefings Bioinf [Internet]. 2022;23(6):1\u201314. Available from: https:\/\/doi.org\/10.1093\/bib\/bbac456. 2025 Oct 13.","journal-title":"Briefings Bioinf"},{"issue":"7816","key":"8197_CR39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","volume":"583","author":"DE Gordon","year":"2020","unstructured":"Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020;583(7816):459\u201368. https:\/\/doi.org\/10.1038\/s41586-020-2286-9.","journal-title":"Nature"},{"key":"8197_CR40","first-page":"855","volume":"13-17","author":"A Grover","year":"2016","unstructured":"Grover A, Leskovec J. Node2vec: scalable feature learning for networks. Proc ACM SIGKDD Int Conf Knowl Discov Data Min. 2016;13-17:855\u201364.","journal-title":"Proc ACM SIGKDD Int Conf Knowl Discov Data Min"},{"issue":"21","key":"8197_CR41","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1093\/bioinformatics\/btx431","volume":"33","author":"JJ Almagro Armenteros","year":"2017","unstructured":"Almagro Armenteros JJ, S\u00f8nderby, S\u00f8nderby, Nielsen H, Winther O, S\u00f8nderby CK, et al. DeepLoc: prediction of protein subcellular localization using deep learning. Bioinformatics [Internet]. 2017;33(21):3387\u201395. Available from: https:\/\/doi.org\/10.1093\/bioinformatics\/btx431. 2025 Oct 13.","journal-title":"Bioinformatics"},{"key":"8197_CR42","doi-asserted-by":"crossref","unstructured":"Raudvere U, Kolberg L, Kuzmin I, Arak T, Adler P, Peterson H, et al. G: profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res [Internet]. 2019;47(W1):W191\u20138. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31066453\/. 2025 Nov 25.","DOI":"10.1093\/nar\/gkz369"},{"key":"8197_CR43","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.1016\/j.csbj.2025.11.035","volume":"27","author":"FD Keogh","year":"2025","unstructured":"Keogh FD, Marx J, Hiemisch A, Koenig R. Slimformer: an NLP-based web server for semantic categorization of gene sets. Comput Struct Biotechnol J [Internet]. 2025;27:5252\u201362. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2001037025005021. 2025 Nov 25.","journal-title":"Comput Struct Biotechnol J"},{"key":"8197_CR44","doi-asserted-by":"crossref","unstructured":"Zhang Y, Jia Z, Yuan G, Chen K, Cen J, Wang J, et al. HnRNPC triggers the degradation of MITA to suppress the interferon-mediated antiviral response. Vet Res [Internet]. 2025. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11854013\/. 2025 Nov 1.","DOI":"10.1186\/s13567-025-01463-6"},{"key":"8197_CR45","doi-asserted-by":"publisher","first-page":"100579","DOI":"10.1016\/j.jbc.2021.100579","volume":"296","author":"S Kesavardhana","year":"2021","unstructured":"Kesavardhana S, Samir P, Zheng M, Subbarao Malireddi RK, Karki R, Sharma BR, et al. DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response. J Biol Chem [Internet]. 2021;296:100579. https:\/\/pubmed.ncbi.nlm.nih.gov\/33766561\/. 2025 Nov 1].","journal-title":"J Biol Chem"},{"key":"8197_CR46","doi-asserted-by":"crossref","unstructured":"Yang SNY, Atkinson SC, Audsley MD, Heaton SM, Jans DA, Borg NA. RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X. Cells. 2020 [cited 2025 Nov 1];9(1):170. Available from: https:\/\/www.mdpi.com\/2073-4409\/9\/1\/170\/htm.","DOI":"10.3390\/cells9010170"},{"key":"8197_CR47","doi-asserted-by":"publisher","unstructured":"Landeras-Bueno S, Jorba N, P\u00e9rez-Cidoncha M, Ort\u00edn J. The splicing factor proline-glutamine rich (SFPQ\/PSF) is involved in influenza virus transcription. PLoS Pathog [Internet]. 2011;7(11):e1002397. Available from: https:\/\/doi.org\/10.1371\/journal.ppat.1002397. 2025 Nov 1.","DOI":"10.1371\/journal.ppat.1002397"},{"key":"8197_CR48","doi-asserted-by":"crossref","unstructured":"Labeau A, Fery-Simonian L, Lefevre-Utile A, Pourcelot M, Bonnet-Madin L, Soumelis V, et al. Characterization and functional interrogation of the SARS-CoV-2 RNA interactome. Cell Rep [Internet]. 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/35477000\/. 2025 Nov 1.","DOI":"10.1101\/2021.03.23.436611"},{"key":"8197_CR49","doi-asserted-by":"publisher","unstructured":"Wang G, Jiang L, Yan Y, Kong F, Li Q, Zhang J, et al. Cellular SLC35B4 promotes internalization during influenza A virus entry. Mbio [Internet]. 2025;16(5). https:\/\/doi.org\/10.1128\/mbio.00194-25. 2026 Mar 11.","DOI":"10.1128\/mbio.00194-25"},{"key":"8197_CR50","doi-asserted-by":"publisher","unstructured":"Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, et al. The G protein-coupled receptor FFAR2 promotes internalization during influenza a virus entry. J Virol [Internet]. 2020;94(2). https:\/\/doi.org\/10.1128\/JVI.01707-19. 2026 Mar 11.","DOI":"10.1128\/JVI.01707-19"},{"key":"8197_CR51","doi-asserted-by":"publisher","unstructured":"Ang F, Wong APY, Ng MML, Chu JJH. Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus. Virol J. 2010 [cited 2026 Mar 11];7:24\u2013. Available from: https:\/\/doi.org\/10.1186\/1743-422X-7-24","DOI":"10.1186\/1743-422X-7-24"},{"issue":"9","key":"8197_CR52","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1128\/JVI.02210-06","volume":"81","author":"MN Krishnan","year":"2007","unstructured":"Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, et al. Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol [Internet]. 2007;81(9):4881\u201385. Available from: https:\/\/doi.org\/10.1128\/JVI.02210-06. 2026 Mar 11.","journal-title":"J Virol"},{"key":"8197_CR53","doi-asserted-by":"crossref","unstructured":"Chen Y, Klute S, Sparrer KMJ, Serra-Moreno R. RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles. Mbio [Internet]. 2025. https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.03314-24?download=true. 2025 Nov 24].","DOI":"10.1128\/mbio.03314-24"},{"issue":"4","key":"8197_CR54","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1128\/jvi.69.4.2306-2312.1995","volume":"69","author":"R G","year":"1995","unstructured":"G R, C L. Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells. J Virol [Internet]. 1995;69(4):2306\u201312. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/7884876\/. 2026 Mar 11.","journal-title":"J Virol"},{"key":"8197_CR55","doi-asserted-by":"crossref","unstructured":"Sabino C, Basic M, Bender D, Elgner F, Himmelsbach K, Hildt E. Bafilomycin A1 and U18666A efficiently impair ZIKV infection. Viruses [Internet]. 2019. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6630673\/. 2026 Mar 11.","DOI":"10.3390\/v11060524"},{"key":"8197_CR56","doi-asserted-by":"crossref","unstructured":"Zhang C, Min YQ, Xue H, Zhang H, Liu K, Tian Y, et al. Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target. Nat Commun, 161 [Internet]. 2025 [cited 2026 Mar 14] 16(1):6326\u2013. Available from: https:\/\/www.nature.com\/articles\/s41467-025-61431-8.","DOI":"10.1038\/s41467-025-61431-8"},{"issue":"5","key":"8197_CR57","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1128\/JVI.02277-12","volume":"87","author":"E Sun","year":"2013","unstructured":"Sun E, He J, Zhuang X. Dissecting the role of COPI complexes in influenza virus infection. J Virol [Internet]. 2013;87(5):2673\u201385. Available from: https:\/\/doi.org\/10.1128\/JVI.02277-12. 2026 Mar 14.","journal-title":"J Virol"},{"issue":"1","key":"8197_CR58","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0168-1702(01)00263-5","volume":"77","author":"K Watanabe","year":"2001","unstructured":"Watanabe K, Takizawa N, Katoh M, Hoshida K, Kobayashi N, Nagata K. Inhibition of nuclear export of ribonucleoprotein complexes of influenza virus by leptomycin B. Virus Res [Internet]. 2001;77(1):31\u201342. Available from: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0168170201002635?via%3Dihub. 2026 Mar 14.","journal-title":"Virus Res"},{"key":"8197_CR59","doi-asserted-by":"crossref","unstructured":"Kashyap T, Murray J, Walker CJ, Chang H, Tamir S, Hou B, et al. Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral res [Internet]. 2021 [cited 2026 Mar 14], 192, 105115. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8213878\/.","DOI":"10.1016\/j.antiviral.2021.105115"},{"key":"8197_CR60","doi-asserted-by":"publisher","unstructured":"Itoh Y, Miyamoto Y, Tokunaga M, Suzuki T, Takada A, Ninomiya A, et al. Importin-7-dependent nuclear translocation of the flavivirus core protein is required for infectious virus production. PLoS Pathog [Internet]. 2024;20(8):e1012409. Available from: https:\/\/doi.org\/10.1371\/journal.ppat.1012409. 2025 Oct 13.","DOI":"10.1371\/journal.ppat.1012409"},{"issue":"12","key":"8197_CR61","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/v9120388","volume":"9","author":"PD Slaine","year":"2017","unstructured":"Slaine PD, Kleer M, Smith NK, Khaperskyy DA, McCormick C. Stress granule-inducing eukaryotic translation initiation factor 4A inhibitors block influenza a virus replication. Viruses [Internet]. 2017;9(12):388. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5744162\/. 2026 Mar 14.","journal-title":"Viruses"},{"key":"8197_CR62","doi-asserted-by":"publisher","first-page":"105012","DOI":"10.1016\/j.antiviral.2021.105012","volume":"186","author":"C M\u00fcller","year":"2021","unstructured":"M\u00fcller C, Obermann W, Karl N, Wendel HG, Taroncher-Oldenburg G, Pleschka S, et al. The rocaglate CR-31-B (\u2212) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo. Antiviral Res [Internet]. 2021;186. Available from: https:\/\/doi.org\/10.1016\/j.antiviral.2021.105012. 2026 Mar 14.","journal-title":"Antiviral Res"},{"issue":"3","key":"8197_CR63","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1099\/vir.0.007021-0","volume":"90","author":"C Polacek","year":"2009","unstructured":"Polacek C, Friebe P, Harris E. Poly(A)-binding protein binds to the non-polyadenylated 3\u2032 untranslated region of dengue virus and modulates translation efficiency. J Gener Virol [Internet]. 2009;90(3):687\u201392. Available from: https:\/\/doi.org\/10.1099\/vir.0.007021-0. 2026 Mar 14.","journal-title":"J Gener Virol"},{"issue":"3","key":"8197_CR64","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41564-020-00846-z","volume":"6","author":"N Schmidt","year":"2020","unstructured":"Schmidt N, Lareau CA, Keshishian H, Ganskih S, Schneider C, Hennig T, et al. The SARS-CoV-2 RNA\u2013protein interactome in infected human cells. Nat Microbiol, 63 [Internet]. 2020 [cited 2026 Mar 14]; 6(3):339\u201353. Available from: https:\/\/www.nature.com\/articles\/s41564-020-00846-z.","journal-title":"Nat Microbiol"},{"issue":"17","key":"8197_CR65","doi-asserted-by":"publisher","first-page":"9876","DOI":"10.1021\/acs.jmedchem.0c01039","volume":"63","author":"V Riva","year":"2020","unstructured":"Riva V, Garbelli A, Brai A, Casiraghi F, Fazi R, Trivisani CI, et al. Unique domain for a Unique target: selective inhibitors of host cell DDX3X to fight Emerging viruses. J Med Chem [Internet]. 2020;63(17):9876\u201387. Available from: https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01039. 2026 Mar 14.","journal-title":"J Med Chem"},{"key":"8197_CR66","doi-asserted-by":"crossref","unstructured":"Vesuna F, Akhrymuk I, Smith A, Winnard PT, Lin S-C, Scharpf R, et al. RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2. bioRxiv prepr serv biol [Internet]. 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/35262079\/. 2026 Mar 14];.","DOI":"10.1101\/2022.02.28.482334"},{"issue":"10","key":"8197_CR67","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ni.3830","volume":"18","author":"Q Zheng","year":"2017","unstructured":"Zheng Q, Hou J, Zhou Y, Li Z, Cao X. The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus. Nat Immunol [Internet]. 2017;18(10):1094\u2013103. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28846086\/. 2025 Oct 13.","journal-title":"Nat Immunol"},{"key":"8197_CR68","doi-asserted-by":"publisher","unstructured":"Dechtawewat T, Songprakhon P, Limjindaporn T, Puttikhunt C, Kasinrerk W, Saitornuang S, et al. Role of human heterogeneous nuclear ribonucleoprotein C1\/C2 in dengue virus replication. Virol J, 121 [Internet]. 2015 [cited 2026 Mar 14] 12(1):14\u2013. Available from: https:\/\/doi.org\/10.1186\/s12985-014-0219-7.","DOI":"10.1186\/s12985-014-0219-7"},{"issue":"1","key":"8197_CR69","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1080\/22221751.2022.2032372","volume":"11","author":"X Zhang","year":"2022","unstructured":"Zhang X, Chu H, Chik KKH, Wen L, Shuai H, Yang D, et al. hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRnas and cognitive mRNAs. Emerging Microbes Infections [Internet]. 2022;11(1):519. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8843244\/. 2026 Mar 14.","journal-title":"Emerging Microbes Infections"},{"key":"8197_CR70","doi-asserted-by":"publisher","unstructured":"Anderson DE, Cui J, Ye Q, Huang B, Tan Y, Jiang C, et al. Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. Proc Natl Acad Sci USA [Internet]. 2021;118(39):e2104759118. Available from: https:\/\/doi.org\/10.1073\/pnas.2104759118. 2026 Mar 14.","DOI":"10.1073\/pnas.2104759118"},{"issue":"10","key":"8197_CR71","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3390\/v10100559","volume":"10","author":"G Sager","year":"2018","unstructured":"Sager G, Gabaglio S, Sztul E, Belov GA. Role of host cell secretory machinery in Zika virus life cycle. Viruses [Internet]. 2018;10(10):559. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6213159\/. 2026 Mar 14.","journal-title":"Viruses"},{"key":"8197_CR72","doi-asserted-by":"crossref","unstructured":"Li J, Gui Q, Liang F-X, Sall J, Zhang Q, Duan Y, et al. The REEP5\/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication. J Virol [Internet]. 2023. https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.00507-23?download=true. 2025 Nov 24.","DOI":"10.1128\/jvi.00507-23"},{"key":"8197_CR73","doi-asserted-by":"crossref","unstructured":"Rao Y, Qin C, Espinosa B, Wang TY, Feng S, Savas AC, et al. Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection. Mbio [Internet]. 2025. https:\/\/pubmed.ncbi.nlm.nih.gov\/40298378\/. 2025 Oct 13.","DOI":"10.1128\/mbio.00649-25"},{"issue":"2","key":"8197_CR74","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1128\/JVI.00877-10","volume":"85","author":"K Xu","year":"2011","unstructured":"Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng B-J, et al. Modification of Nonstructural protein 1 of influenza a virus by SUMO1. J Virol [Internet]. 2011;85(2):1086\u201398. Available from: https:\/\/doi.org\/10.1128\/JVI.00877-10. 2026 Mar 14.","journal-title":"J Virol"},{"issue":"7","key":"8197_CR75","doi-asserted-by":"publisher","first-page":"2104126","DOI":"10.1002\/advs.202104126","volume":"9","author":"Y Fan","year":"2022","unstructured":"Fan Y, Li X, Zhang L, Zong Z, Wang F, Huang J, et al. Sumoylation in viral replication and antiviral defense. Adv Sci [Internet]. 2022;9(7):2104126. Available from: https:\/\/doi.org\/10.1002\/advs.202104126. 2026 Mar 14.","journal-title":"Adv Sci"},{"issue":"17","key":"8197_CR76","doi-asserted-by":"publisher","first-page":"9122","DOI":"10.1128\/JVI.00789-12","volume":"86","author":"D Moisy","year":"2012","unstructured":"Moisy D, Avilov S V, Jacob Y, Laoide BM, Ge X, Baudin F, et al. HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. J Virol [Internet]. 2012;86(17):9122\u201333. Available from: https:\/\/doi.org\/10.1128\/JVI.00789-12. 2026 Mar 14.","journal-title":"J Virol"},{"issue":"1","key":"8197_CR77","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.celrep.2016.06.028","volume":"16","author":"G Savidis","year":"2016","unstructured":"Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, et al. Identification of Zika Virus and dengue virus dependency factors using functional Genomics. Cell Rep [Internet]. 2016;16(1):232\u201346. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/27342126\/. 2025 Sep 9.","journal-title":"Cell Rep"},{"issue":"1","key":"8197_CR78","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tcb.2005.11.001","volume":"16","author":"DS Carney","year":"2006","unstructured":"Carney DS, Davies BA, Horazdovsky BF. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Trends Cell Biol [Internet]. 2006;16(1):27\u201335. Available from: https:\/\/www.cell.com\/action\/showFullText?pii=S0962892405002989. 2026 Mar 14.","journal-title":"Trends Cell Biol"},{"key":"8197_CR79","doi-asserted-by":"publisher","unstructured":"Tapescu I, Cherry S. DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunity. J Virol [Internet]. 2024;98(10). https:\/\/doi.org\/10.1128\/jvi.00040-24. 2025 Nov 3];.","DOI":"10.1128\/jvi.00040-24"},{"key":"8197_CR80","doi-asserted-by":"publisher","first-page":"407205","DOI":"10.3389\/fcimb.2018.00396","volume":"8","author":"Y Fan","year":"2018","unstructured":"Fan Y, Sanyal S, Bruzzone R. Breaking bad: how viruses subvert the cell cycle. Front Cell Infect Microbiol. 2018;8:407205. https:\/\/doi.org\/10.3389\/fcimb.2018.00396.","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"8197_CR81","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.dnarep.2009.04.016","volume":"8","author":"MS Chaurushiya","year":"2009","unstructured":"Chaurushiya MS, Weitzman MD. Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) [Internet]. 2009;8(9):1166. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2725192\/. 2025 Nov 3.","journal-title":"DNA Repair (Amst)"},{"key":"8197_CR82","doi-asserted-by":"crossref","unstructured":"Puerta-Guardo H, Biering SB, de Sousa FTG, Shu J, Glasner DR, Li J, et al. Flavivirus NS1 triggers tissue-specific disassembly of intercellular Junctions leading to barrier dysfunction and Vascular leak in a GSK-3\u03b2-dependent manner. Pathogens. 2022 [cited 2025 Nov 23], 11, [Internet]. 615. Available from: https:\/\/www.mdpi.com\/2076-0817\/11\/6\/615\/htm.","DOI":"10.3390\/pathogens11060615"},{"key":"8197_CR83","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1093\/infdis\/jix041","volume":"215","author":"S Suwarto","year":"2017","unstructured":"Suwarto S, Sasmono RT, Sinto R, Ibrahim E, Suryamin M. Association of Endothelial Glycocalyx and tight and adherens junctions with severity of plasma leakage in dengue infection. The J Infect Dis [Internet]. 2017;215:992\u201399. Available from: https:\/\/doi.org\/10.1093\/infdis\/jix041. 2025 Oct 11.","journal-title":"The J Infect Dis"},{"key":"8197_CR84","doi-asserted-by":"crossref","unstructured":"Boudreault S, Roy P, Lemay G, Bisaillon M. Viral modulation of cellular RNA alternative splicing: a new key player in virus\u2013host interactions? WIREs RNA [Internet]. 2019;10(5):e1543. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6767064\/. 2025 Nov 23.","DOI":"10.1002\/wrna.1543"},{"issue":"3","key":"8197_CR85","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/wrna.1162","volume":"4","author":"RE Lloyd","year":"2013","unstructured":"Lloyd RE. Regulation of stress granules and P-bodies during RNA virus infection. WIREs RNA [Internet]. 2013;4(3):317. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3652661\/. 2025 Nov 23.","journal-title":"WIREs RNA"},{"key":"8197_CR86","doi-asserted-by":"crossref","unstructured":"Kim J, Song CH. Stress granules in infectious disease: cellular principles and dynamic roles in immunity and organelles. Int J Mol Sci. 2024 [cited 2025 Nov 23];25:12950. Available from: https:\/\/www.mdpi.com\/1422-0067\/25\/23\/12950\/htm.","DOI":"10.3390\/ijms252312950"},{"key":"8197_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coviro.2015.09.005","volume":"17","author":"H Luo","year":"2016","unstructured":"Luo H. Interplay between the virus and the ubiquitin\u2013proteasome system: molecular mechanism of viral pathogenesis. Curr Opin Virol [Internet]. 2016;17:1\u201310. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1879625715001406?utm_source=chatgpt.com. 2025 Nov 23.","journal-title":"Curr Opin Virol"},{"issue":"3","key":"8197_CR88","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/boc.201100105","volume":"104","author":"YE Wang","year":"2012","unstructured":"Wang YE, Pernet O, Lee B. Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biol Cell [Internet]. 2012;104(3):121. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3625690\/. 2025 Nov 23.","journal-title":"Biol Cell"},{"issue":"1","key":"8197_CR89","first-page":"1","volume":"16","author":"Z Lu","year":"2025","unstructured":"Lu Z, Song G, Zhu H, Lei C, Sun X, Wang K, et al. DTIAM: a unified framework for predicting drug-target interactions, binding affinities and drug mechanisms. Nat Commun [Internet]. 2025;16(1):1\u201317. Available from: https:\/\/www.nature.com\/articles\/s41467-025-57828-0. 2025 Oct 13.","journal-title":"Nat Commun"},{"key":"8197_CR90","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.antiviral.2018.07.006","volume":"157","author":"T Schr\u00e4der","year":"2018","unstructured":"Schr\u00e4der T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S. The clinically approved MEK inhibitor trametinib efficiently blocks influenza a virus propagation and cytokine expression. Antiviral Res [Internet]. 2018;157:80\u201392. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29990517\/. 2025 Oct 13.","journal-title":"Antiviral Res"},{"key":"8197_CR91","doi-asserted-by":"crossref","unstructured":"Valencia HJ, de Aguiar MCAM, Costa MA, Mendon\u00e7a DC, Reis EV, Arias NEC, et al. Evaluation of kinase inhibitors as potential therapeutics for flavivirus infections. Arch Virol. 2021 [cited 2025 Oct 13];166:1433. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7938686.","DOI":"10.1007\/s00705-021-05021-1"},{"key":"8197_CR92","doi-asserted-by":"crossref","unstructured":"de Wispelaere M, LaCroix AJ, Yang PL, de Wispelaere M. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via fyn kinase. J Virol [Internet]. 2013;87(13):7367. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3700292\/. 2025 Oct 13.","DOI":"10.1128\/JVI.00632-13"},{"issue":"9","key":"8197_CR93","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.1073\/pnas.0611681104","volume":"104","author":"JJH Chu","year":"2007","unstructured":"Chu JJH, Yang PL. C-src protein kinase inhibitors block assembly and maturation of dengue virus. Proc Natl Acad Sci USA [Internet]. 2007;104(9):3520\u201325. Available from: https:\/\/doi.org\/10.1073\/pnas.0611681104. 2025 Oct 13.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"8197_CR94","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1038\/s41401-020-00556-6","volume":"42","author":"L Yang","year":"2021","unstructured":"Yang L, Pei R-J, Li H, Ma X-N, Zhou Y, Zhu F-H, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin [Internet]. 2021;42(8):1347\u201353. Available from: https:\/\/www.nature.com\/articles\/s41401-020-00556-6. 2025 Oct 13.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"8197_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-09664-1","volume":"12","author":"R Strobelt","year":"2022","unstructured":"Strobelt R, Adler J, Paran N, Yahalom-Ronen Y, Melamed S, Politi B, et al. Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism. Sci Rep [Internet]. 2022;12(1):1\u201311. Available from: https:\/\/www.nature.com\/articles\/s41598-022-09664-1. 2025 Oct 13.","journal-title":"Sci Rep"},{"key":"8197_CR96","doi-asserted-by":"crossref","unstructured":"Carre\u00f1o-Fl\u00f3rez GP, Cuartas-L\u00f3pez AM, Boudreau RL, Vicente-Manzanares M, Gallego-G\u00f3mez JC. Role of c-ABL in DENV-2 infection and actin remodeling in Vero cells. Int J Mol Sci. 2025 [cited 2025 Oct 13];26:4206. Available from: https:\/\/www.mdpi.com\/1422-0067\/26\/9\/4206\/htm.","DOI":"10.3390\/ijms26094206"},{"key":"8197_CR97","doi-asserted-by":"publisher","first-page":"105137","DOI":"10.1016\/j.antiviral.2021.105137","volume":"193","author":"F Touret","year":"2021","unstructured":"Touret F, Driouich JS, Cochin M, Petit PR, Gilles M, Barth\u00e9l\u00e9my K, et al. Preclinical evaluation of imatinib does not support its use as an antiviral drug against SARS-CoV-2. Antiviral Res [Internet]. 2021;193:105137. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8274277\/. 2025 Oct 13.","journal-title":"Antiviral Res"},{"key":"8197_CR98","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.lfs.2017.10.027","volume":"191","author":"A Duran","year":"2017","unstructured":"Duran A, Valero N, Mosquera J, Fuenmayor E, Alvarez-Mon M. Gefitinib and pyrrolidine dithiocarbamate decrease viral replication and cytokine production in dengue virus infected human monocyte cultures. Life Sci [Internet]. 2017;191:180\u201385. Available from: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0024320517305416?via%3Dihub. 2025 Oct 13.","journal-title":"Life Sci"},{"key":"8197_CR99","doi-asserted-by":"publisher","unstructured":"Han Y, Kim S, Park T, Hwang H, Park S, Kim J, et al. Reduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection by blocking the epidermal growth factor receptor (EGFR) pathway. Microbiol. Spectr [Internet]. 2024;12(11). https:\/\/doi.org\/10.1128\/spectrum.01583-24. 2025 Oct 13];.","DOI":"10.1128\/spectrum.01583-24"},{"key":"8197_CR100","doi-asserted-by":"publisher","first-page":"586572","DOI":"10.3389\/fimmu.2020.586572","volume":"11","author":"X Xiao","year":"2020","unstructured":"Xiao X, Wang C, Chang D, Wang Y, Dong X, Jiao T, et al. Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2. Front Immunol [Internet]. 2020;11:586572. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7723961\/. 2025 Oct 13.","journal-title":"Front Immunol"},{"key":"8197_CR101","doi-asserted-by":"crossref","unstructured":"Lin X, Ke X, Jian X, Xia L, Yang Y, Zhang T, et al. Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19. Sci Bull. 2022 [cited 2025 Oct 13];67:1022. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8837489\/","DOI":"10.1016\/j.scib.2022.02.002"},{"key":"8197_CR102","unstructured":"Eyr NS, Kirb EN, Anfiteatr DR, Bracho G, Russ AG, Whit PA, et al. Identification of estrogen receptor modulators as inhibitors of flavivirus infection. Antimicrob agents chemother [Internet]. 2020. https:\/\/pubmed.ncbi.nlm.nih.gov\/32482672\/. 2025 Oct 13."},{"key":"8197_CR103","unstructured":"Estrogen protects women against the flu, study finds | infection control today [Internet]. [ https:\/\/www.infectioncontroltoday.com\/view\/estrogen-protects-women-against-flu-study-finds. 2025 Dec 8]."},{"key":"8197_CR104","doi-asserted-by":"crossref","unstructured":"Iaconis D, Bordi L, Matusali G, Talarico C, Manelfi C, Cesta MC, et al. Characterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants. Cell death dis [Internet]. 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/35614039\/. 2025 Oct 13].","DOI":"10.1038\/s41419-022-04961-z"},{"issue":"6","key":"8197_CR105","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1021\/acsptsci.0c00131","volume":"3","author":"G Bocci","year":"2020","unstructured":"Bocci G, Bradfute SB, Ye C, Garcia MJ, Parvathareddy J, Reichard W, et al. Virtual and in vitro antiviral screening revive therapeutic drugs for COVID-19. ACS Pharmacol Transl Sci [Internet]. 2020;3(6):1278\u201392. Available from: https:\/\/doi.org\/10.1021\/acsptsci.0c00131. 2025 Oct 13.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"8197_CR106","doi-asserted-by":"crossref","unstructured":"LoMascolo NJ, Cruz-Pulido YE, Mounce BC. Bisacodyl limits Chikungunya virus replication in vitro and is broadly antiviral. Antimicrob agents chemother [Internet]. 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/35652314\/. 2025 Oct 13.","DOI":"10.1128\/aac.00292-22"},{"issue":"7","key":"8197_CR107","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1083\/jcb.200311064","volume":"164","author":"AA Peden","year":"2004","unstructured":"Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol [Internet]. 2004;164(7):1065\u201376. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/15051738\/. 2025 Nov 24.","journal-title":"J Cell Biol"},{"key":"8197_CR108","doi-asserted-by":"publisher","unstructured":"Van Der Schaar HM, Rust MJ, Chen C, van der Ende-Metselaar H, Wilschut J, Zhuang X, et al. Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathog [Internet]. 2008;4(12):e1000244. Available from: https:\/\/doi.org\/10.1371\/journal.ppat.1000244. 2025 Nov 24.","DOI":"10.1371\/journal.ppat.1000244"},{"issue":"6","key":"8197_CR109","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.celrep.2019.01.036","volume":"26","author":"H Puerta-Guardo","year":"2019","unstructured":"Puerta-Guardo H, Glasner DR, Espinosa DA, Biering SB, Patana M, Ratnasiri K, et al. Flavivirus NS1 triggers tissue-specific vascular endothelial dysfunction reflecting disease tropism. Cell Rep [Internet]. 2019;26(6):1598\u2013613.e8. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30726741\/. 2025 Nov 3.","journal-title":"Cell Rep"},{"issue":"7","key":"8197_CR110","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","volume":"139","author":"AL Brass","year":"2009","unstructured":"Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, et al. The IFITM proteins mediate cellular resistance to influenza a H1N1 virus, West Nile virus, and dengue virus. Cell [Internet]. 2009;139(7):1243\u201354. Available from: https:\/\/doi.org\/10.1016\/j.cell.2009.12.017.","journal-title":"Cell"},{"issue":"2","key":"8197_CR111","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1128\/JVI.06519-11","volume":"87","author":"S Huang","year":"2013","unstructured":"Huang S, Chen J, Chen Q, Wang H, Yao Y, Chen J, et al. A second CRM1-dependent nuclear export signal in the influenza a virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins. J Virol [Internet]. 2013;87(2):767. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3554077\/. 2025 Oct 13.","journal-title":"J Virol"},{"key":"8197_CR112","doi-asserted-by":"crossref","unstructured":"Tsai PL, Chiou NT, Kuss S, Garc\u00eda-Sastre A, Lynch KW, Fontoura BMA. Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza a virus RNA splicing. PLoS pathog [Internet]. 2013. https:\/\/pubmed.ncbi.nlm.nih.gov\/23825951\/. 2025 Oct 13];.","DOI":"10.1371\/journal.ppat.1003460"},{"key":"8197_CR113","doi-asserted-by":"crossref","unstructured":"Firdaus MER, Dukhno E, Kapoor R, Gerlach P. Two birds with one stone: RNA virus strategies to manipulate G3BP1 and other stress granule components. WIREs RNA [Internet]. 2025;16(2):e70005. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11962251\/. 2025 Oct 13.","DOI":"10.1002\/wrna.70005"},{"issue":"16","key":"8197_CR114","doi-asserted-by":"publisher","first-page":"9379","DOI":"10.1128\/JVI.00509-14","volume":"88","author":"Q Han","year":"2014","unstructured":"Han Q, Chang C, Li L, Klenk C, Cheng J, Chen Y, et al. Sumoylation of influenza a virus nucleoprotein is essential for intracellular trafficking and virus growth. J Virol [Internet]. 2014;88(16):9379\u201390. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/24920808\/. 2025 Nov 24.","journal-title":"J Virol"},{"issue":"9","key":"8197_CR115","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.1128\/JVI.00223-16","volume":"90","author":"C-I Su","year":"2016","unstructured":"Su C-I, Tseng C-H, Yu C-Y, Lai MMC, Jung JU. SUMO Modification stabilizes dengue virus nonstructural protein 5 to support virus replication. J Virol [Internet]. 2016;90(9):4308\u201319. Available from: https:\/\/doi.org\/10.1128\/JVI.00223-16. 2025 Nov 24.","journal-title":"J Virol"},{"key":"8197_CR116","doi-asserted-by":"crossref","unstructured":"Ren J, Wang S, Zong Z, Pan T, Liu S, Mao W, et al. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Nat Commun, 151 [Internet]. 2024 [cited 2025 Nov 24], 15(1):244\u2013. Available from: https:\/\/www.nature.com\/articles\/s41467-023-44502-6.","DOI":"10.1038\/s41467-023-44502-6"},{"issue":"15","key":"8197_CR117","doi-asserted-by":"publisher","first-page":"8700","DOI":"10.1093\/nar\/gkac645","volume":"50","author":"D Zhou","year":"2022","unstructured":"Zhou D, Wu Z, Park JG, Fiches GN, Li TW, Ma Q, et al. FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling. Nucleic Acids Res [Internet]. 2022;50(15):8700\u201318. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35904816\/. 2025 Nov 24.","journal-title":"Nucleic Acids Res"},{"key":"8197_CR118","doi-asserted-by":"crossref","unstructured":"Dong Y, Ming B, Dong L. The role of HMGB1 in rheumatic diseases. Front immunol [Internet]. 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/35250993\/. 2025 Nov 24.","DOI":"10.3389\/fimmu.2022.815257"},{"key":"8197_CR119","doi-asserted-by":"crossref","unstructured":"Yang J, Tian B, Wang P, Chen R, Xiao K, Long X, et al. SARS-CoV-2 NSP3\/4 control formation of replication organelle and recruitment of RNA polymerase NSP12. J cell biol [Internet]. 2025. https:\/\/pubmed.ncbi.nlm.nih.gov\/39737877\/. 2025 Nov 24];.","DOI":"10.1083\/jcb.202306101"},{"key":"8197_CR120","doi-asserted-by":"crossref","unstructured":"Fang J, Pietzsch C, Ramanathan P, Santos RI, Ilinykh PA, Garcia-Blanco MA, et al. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. Mbio [Internet]. 2018. https:\/\/pubmed.ncbi.nlm.nih.gov\/30301857\/. 2025 Sep 10.","DOI":"10.1128\/mBio.01771-18"},{"issue":"5","key":"8197_CR121","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1189\/jlb.4RI0316-099RR","volume":"100","author":"A Rivera","year":"2016","unstructured":"Rivera A, Messaoudi I. Molecular mechanisms of Ebola pathogenesis. J Leukoc Biol [Internet]. 2016;100(5):889. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6608070\/. 2025 Oct 12.","journal-title":"J Leukoc Biol"},{"issue":"12","key":"8197_CR122","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1074\/mcp.M110.003418","volume":"9","author":"KB Spurgers","year":"2010","unstructured":"Spurgers KB, Alefantis T, Peyser BD, Ruthel GT, Bergeron AA, Costantino JA, et al. Identification of essential filovirion-associated host factors by serial Proteomic analysis and RNAi screen. Mol Cellular Proteomics [Internet]. 2010;9(12):2690. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3101857\/. 2025 Oct 12.","journal-title":"Mol Cellular Proteomics"},{"issue":"2","key":"8197_CR123","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.antiviral.2010.04.015","volume":"87","author":"DR Smith","year":"2010","unstructured":"Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, et al. Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Res [Internet]. 2010;87(2):187\u201394. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/20452380\/. 2025 Oct 12.","journal-title":"Antiviral Res"},{"issue":"12","key":"8197_CR124","doi-asserted-by":"publisher","first-page":"110544","DOI":"10.1016\/j.celrep.2022.110544","volume":"38","author":"J Fang","year":"2022","unstructured":"Fang J, Pietzsch C, Tsaprailis G, Crynen G, Cho KF, Ting AY, et al. Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication. Cell Rep [Internet]. 2022;38(12):110544. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10496643\/. 2025 Oct 12.","journal-title":"Cell Rep"},{"issue":"2","key":"8197_CR125","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0166-3542(00)00066-8","volume":"45","author":"M Bray","year":"2000","unstructured":"Bray M, Driscoll J, Huggins JW. Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. Antiviral Res [Internet]. 2000;45(2):135\u201347. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/10809022\/. 2025 Oct 12.","journal-title":"Antiviral Res"},{"key":"8197_CR126","doi-asserted-by":"crossref","unstructured":"Spence JS, Krause TB, Mittler E, Jangra RK, Chandran K. Direct visualization of Ebola virus fusion triggering in the endocytic pathway. Mbio [Internet]. 2016. https:\/\/pubmed.ncbi.nlm.nih.gov\/26861015\/. 2025 Oct 12.","DOI":"10.1128\/mBio.01857-15"},{"key":"8197_CR127","doi-asserted-by":"publisher","first-page":"101304","DOI":"10.1016\/j.coviro.2023.101304","volume":"59","author":"S Ludwig","year":"2023","unstructured":"Ludwig S, Pleschka S, Planz O. MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases. Curr Opin Virol [Internet]. 2023;59:101304. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1879625723000044?utm_source=chatgpt.com. 2025 Oct 13.","journal-title":"Curr Opin Virol"},{"key":"8197_CR128","doi-asserted-by":"crossref","unstructured":"Hajjo R, Sabbah DA, Abusara OH, Kharmah R, Bardaweel S. Targeting human proteins for antiviral drug discovery and repurposing efforts: a focus on protein kinases. Viruses. 2023 [cited 2025 Nov 3];15:568. Available from: https:\/\/www.mdpi.com\/1999-4915\/15\/2\/568\/htm","DOI":"10.3390\/v15020568"},{"key":"8197_CR129","doi-asserted-by":"crossref","unstructured":"O\u2019Donovan SM, Imami A, Eby H, Henkel ND, Creeden JF, Asah S, et al. Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach. Sci Rep. 2021 [cited 2025 Nov 3];11:1\u201312. Available from: https:\/\/www.nature.com\/articles\/s41598-021-84044-9","DOI":"10.1038\/s41598-021-84044-9"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08197-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08197-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08197-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:02:55Z","timestamp":1779264175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08197-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,2]]},"references-count":129,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8197"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08197-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,2]]},"assertion":[{"value":"8 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"685"}}