{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:51:41Z","timestamp":1781751101362,"version":"3.54.5"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271114"],"award-info":[{"award-number":["82271114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08198-8","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:15:03Z","timestamp":1777536903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cargo molecules in plasma neural-derived extracellular vesicles reveal pathological signatures of primary open-angle glaucoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiang-Yuan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Lan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Yun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Wu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Kang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-6425","authenticated-orcid":false,"given":"Zai-Long","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"8198_CR1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng C-Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081\u201390.","journal-title":"Ophthalmology"},{"key":"8198_CR2","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/j.ophtha.2021.04.009","volume":"128","author":"Z Soh","year":"2021","unstructured":"Soh Z, Yu M, Betzler BK, Majithia S, Thakur S, Tham YC, Wong TY, Aung T, Friedman DS, Cheng CY. The global extent of undetected glaucoma in adults: a systematic review and meta-analysis. Ophthalmology. 2021;128:1393\u2013404.","journal-title":"Ophthalmology"},{"key":"8198_CR3","doi-asserted-by":"publisher","first-page":"100875","DOI":"10.1016\/j.preteyeres.2020.100875","volume":"80","author":"G Beykin","year":"2021","unstructured":"Beykin G, Norcia AM, Srinivasan VJ, Dubra A, Goldberg JL. Discovery and clinical translation of novel glaucoma biomarkers. Prog Ret Eye Res. 2021;80:100875.","journal-title":"Prog Ret Eye Res"},{"key":"8198_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.67","volume":"2","author":"RN Weinreb","year":"2016","unstructured":"Weinreb RN, Leung CK, Crowston JG, Medeiros FA, Friedman DS, Wiggs JL, Martin KR. Primary open-angle glaucoma. Nat Rev Dis Primers. 2016;2:1\u201319.","journal-title":"Nat Rev Dis Primers"},{"key":"8198_CR5","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.4103\/1673-5374.338989","volume":"17","author":"B Martinez","year":"2022","unstructured":"Martinez B, Peplow PV. MicroRNAs as biomarkers in glaucoma and potential therapeutic targets. Neural Regener Res. 2022;17:2368\u201375.","journal-title":"Neural Regener Res"},{"key":"8198_CR6","doi-asserted-by":"publisher","first-page":"125826","DOI":"10.1016\/j.talanta.2024.125826","volume":"273","author":"M Botello-Marabotto","year":"2024","unstructured":"Botello-Marabotto M, Mart\u00ednez-Bisbal MC, Pinazo-Dur\u00e1n MD, Mart\u00ednez-M\u00e1nez R. Tear metabolomics for the diagnosis of primary open-angle glaucoma. Talanta. 2024;273:125826.","journal-title":"Talanta"},{"key":"8198_CR7","doi-asserted-by":"publisher","first-page":"114566","DOI":"10.1016\/j.bios.2022.114566","volume":"215","author":"S Gao","year":"2022","unstructured":"Gao S, Li Q, Zhang S, Sun X, Zheng X, Qian H, Wu J. One-step high-throughput detection of low-abundance biomarker BDNF using a biolayer interferometry-based 3D aptasensor. Biosens Bioelectron. 2022;215:114566.","journal-title":"Biosens Bioelectron"},{"key":"8198_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1021\/acssensors.5c02768","volume":"11","author":"J Tao","year":"2025","unstructured":"Tao J, Yang L, Chen J, Yue S, Song C, Liang C, Zhou J, Wang H. Autocatalytic signal amplification via orthogonal recognition of dual proteins on the surface of serum extracellular vesicles for precise diagnosis of prostate cancer. ACS Sens. 2025;11:181\u20139.","journal-title":"ACS Sens"},{"key":"8198_CR9","doi-asserted-by":"publisher","first-page":"102904","DOI":"10.1016\/j.arr.2025.102904","volume":"113","author":"J Pei","year":"2025","unstructured":"Pei J, Perumal N, Meng P, Long Q, Chella Perumal DP. Extracellular vesicle-based biosensors for Alzheimer\u2019s disease: A new frontier in precision diagnostics. Ageing Res Rev. 2025;113:102904.","journal-title":"Ageing Res Rev"},{"key":"8198_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12974-025-03555-8","volume":"22","author":"FJD Machado","year":"2025","unstructured":"Machado FJD, Marta-Enguita J, Herrera M, Marta-Moreno J, P\u00e1ramo JA, Segura T, Serrano-Heras G, Hern\u00e1ndez-Fern\u00e1ndez F, Arias-Salazar L, Y\u00e9lamos-Sanz B, et al. Transcriptomic profiling of thrombus-derived extracellular vesicles reveals PECAM-1 as a potential inflammatory marker for cardioembolic stroke patients. J Neuroinflamm. 2025;22:229.","journal-title":"J Neuroinflamm"},{"key":"8198_CR11","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1186\/s12951-025-03768-2","volume":"23","author":"B Li","year":"2025","unstructured":"Li B, Wu W, Xu W, Qian H, Ji C. Advances of extracellular vesicles isolation and detection frontier technology: from heterogeneity analysis to clinical application. J Nanobiotechnol. 2025;23:678.","journal-title":"J Nanobiotechnol"},{"key":"8198_CR12","doi-asserted-by":"publisher","first-page":"e70156","DOI":"10.1002\/jev2.70156","volume":"14","author":"S Remans","year":"2025","unstructured":"Remans S, Van den Brande S, Vanden Broeck J, Santos D. Extracellular vesicles in arthropods: biogenesis, functions, isolation methods and applications. J Extracell Vesicles. 2025;14:e70156.","journal-title":"J Extracell Vesicles"},{"key":"8198_CR13","doi-asserted-by":"publisher","first-page":"e70160","DOI":"10.1002\/jev2.70160","volume":"14","author":"M Zhen","year":"2025","unstructured":"Zhen M, Xie J, Yang R, Liu L, Liu H, He X, Gao S, Zhu J, Li J, Shu B. Epidermal stem cell-derived extracellular vesicles induce fibroblasts mesenchymal\u2010epidermal transition to alleviate hypertrophic scar formation via miR\u2010200s inhibition of ZEB1 and 2. J Extracell Vesicles. 2025;14:e70160.","journal-title":"J Extracell Vesicles"},{"key":"8198_CR14","doi-asserted-by":"publisher","first-page":"5277","DOI":"10.7150\/thno.113650","volume":"15","author":"J Li","year":"2025","unstructured":"Li J, Wang A, Guo H, Zheng W, Chen R, Miao C, Zheng D, Peng J, Wang J, Chen Z. Exosomes: innovative biomarkers leading the charge in non-invasive cancer diagnostics. Theranostics. 2025;15:5277.","journal-title":"Theranostics"},{"key":"8198_CR15","doi-asserted-by":"publisher","first-page":"28021","DOI":"10.1021\/acsnano.5c00706","volume":"19","author":"HL Tran","year":"2025","unstructured":"Tran HL, Zheng W, Issadore DA, Im H, Cho Y-K, Zhang Y, Liu D, Liu Y, Li B, Liu F. Extracellular vesicles for clinical diagnostics: from bulk measurements to single-vesicle analysis. ACS Nano. 2025;19:28021\u2013109.","journal-title":"ACS Nano"},{"key":"8198_CR16","doi-asserted-by":"publisher","first-page":"e2414982","DOI":"10.1002\/advs.202414982","volume":"12","author":"C Zhao","year":"2025","unstructured":"Zhao C, Wang Z, Kim H, Kong H, Lee J, Yang JZ, Wang A, Zhang RY, Ju Y, Kim J, et al. Identification of tumor-specific surface proteins enables quantification of extracellular vesicle subtypes for early detection of pancreatic ductal adenocarcinoma. Adv Sci. 2025;12:e2414982.","journal-title":"Adv Sci"},{"key":"8198_CR17","doi-asserted-by":"publisher","first-page":"2309307","DOI":"10.1002\/advs.202309307","volume":"11","author":"T Li","year":"2024","unstructured":"Li T, Zhang WM, Wang J, Liu BJ, Gao Q, Zhang J, Qian HD, Pan JY, Liu M, Huang Q. Circulating small extracellular vesicles involved in systemic regulation respond to RGC degeneration in glaucoma. Adv Sci. 2024;11:2309307.","journal-title":"Adv Sci"},{"key":"8198_CR18","doi-asserted-by":"publisher","first-page":"438","DOI":"10.20517\/evcna.2024.45","volume":"5","author":"SL Xu","year":"2024","unstructured":"Xu SL, Li JH, Zhang WM, Fu MJ, Xing HM, Ma H, Gong XH, Wu RH, Liang YB, Cui RZ. Transcriptomic analysis of plasma-derived small extracellular vesicles reveals the pathological characteristics of normal tension glaucoma. Extracell vesicles circ nucleic acids. 2024;5:438.","journal-title":"Extracell vesicles circ nucleic acids"},{"key":"8198_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40035-024-00418-9","volume":"13","author":"JK Bravo-Miana RdC, Arizaga-Echebarria","year":"2024","unstructured":"Bravo-Miana RdC, Arizaga-Echebarria JK, Otaegui D. Central nervous system-derived extracellular vesicles: the next generation of neural circulating biomarkers? Transl Neurodegener. 2024;13:32.","journal-title":"Transl Neurodegener"},{"key":"8198_CR20","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13195-023-01303-9","volume":"15","author":"F Delgado-Peraza","year":"2023","unstructured":"Delgado-Peraza F, Nogueras-Ortiz C, Simonsen AH, Knight DLD, Yao PJ, Goetzl EJ, Jensen CS, H\u00f8gh P, Gottrup H, Vestergaard K. Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer\u2019s disease. Alzheimer\u2019s Res Ther. 2023;15:156.","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"8198_CR21","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.7150\/thno.112396","volume":"15","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, Lai M, Shu B, Wang B, Wang D, Liu H, Li B, Guo J, Hu D, Li M. Unraveling \u03b1-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson\u2019s disease. Theranostics. 2025;15:7409.","journal-title":"Theranostics"},{"key":"8198_CR22","doi-asserted-by":"publisher","first-page":"e12459","DOI":"10.1002\/jev2.12459","volume":"13","author":"CJ Nogueras-Ortiz","year":"2024","unstructured":"Nogueras-Ortiz CJ, Eren E, Yao P, Calzada E, Dunn C, Volpert O, Delgado\u2010Peraza F, Mustapic M, Lyashkov A, Rubio FJ. Single\u2010extracellular vesicle (EV) analyses validate the use of L1 cell adhesion molecule (L1CAM) as a reliable biomarker of neuron\u2010derived EVs. J Extracell Vesicles. 2024;13:e12459.","journal-title":"J Extracell Vesicles"},{"key":"8198_CR23","doi-asserted-by":"publisher","first-page":"103192","DOI":"10.1016\/j.ebiom.2020.103192","volume":"63","author":"A Kumar","year":"2021","unstructured":"Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu F-C. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021;63:103192.","journal-title":"EBioMedicine"},{"key":"8198_CR24","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41592-021-01174-8","volume":"18","author":"M Norman","year":"2021","unstructured":"Norman M, Ter-Ovanesyan D, Trieu W, Lazarovits R, Kowal EJ, Lee JH, Chen-Plotkin AS, Regev A, Church GM, Walt DR. L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma. Nat Methods. 2021;18:631\u20134.","journal-title":"Nat Methods"},{"key":"8198_CR25","doi-asserted-by":"publisher","first-page":"eadi3647","DOI":"10.1126\/sciadv.adi3647","volume":"9","author":"Y You","year":"2023","unstructured":"You Y, Zhang Z, Sultana N, Ericsson M, Martens YA, Sun M, Kanekiyo T, Ikezu S, Shaffer SA, Ikezu T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023;9:eadi3647.","journal-title":"Sci Adv"},{"key":"8198_CR26","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1002\/alz.13055","volume":"19","author":"A Kumar","year":"2023","unstructured":"Kumar A, Su Y, Sharma M, Singh S, Kim S, Peavey JJ, Suerken CK, Lockhart SN, Whitlow CT, Craft S. MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer\u2019s disease. Alzheimer\u2019s Dement. 2023;19:4952\u201366.","journal-title":"Alzheimer\u2019s Dement"},{"key":"8198_CR27","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/cells9071618","volume":"9","author":"CJ Nogueras-Ortiz","year":"2020","unstructured":"Nogueras-Ortiz CJ, Mahairaki V, Delgado-Peraza F, Das D, Avgerinos K, Eren E, Hentschel M, Goetzl EJ, Mattson MP, Kapogiannis D. Astrocyte-and neuron-derived extracellular vesicles from Alzheimer\u2019s disease patients effect complement-mediated neurotoxicity. Cells. 2020;9:1618.","journal-title":"Cells"},{"key":"8198_CR28","doi-asserted-by":"publisher","first-page":"1506560","DOI":"10.3389\/fendo.2025.1506560","volume":"16","author":"Y Shi","year":"2025","unstructured":"Shi Y, He X, Liu W, Hu J, Qiu WQ, Zhang X, Fan Z. Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer\u2019s disease: a large cohort study in UK biobank. Front Endocrinol. 2025;16:1506560.","journal-title":"Front Endocrinol"},{"key":"8198_CR29","doi-asserted-by":"publisher","first-page":"102572","DOI":"10.1016\/j.arr.2024.102572","volume":"102","author":"SP Panda","year":"2024","unstructured":"Panda SP, Kesharwani A, Singh B, Marisetti AL, Chaitanya M, Dahiya S, Ponnusankar S, Kumar S, Singh M, Shakya PK. 14-3-3 protein and its isoforms: A common diagnostic marker for Alzheimer\u2019s disease, Parkinson\u2019s disease and glaucomatous neurodegeneration. Ageing Res Rev. 2024;102:102572.","journal-title":"Ageing Res Rev"},{"key":"8198_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13059-018-1495-0","volume":"19","author":"A Fishman","year":"2018","unstructured":"Fishman A, Light D, Lamm AT. QsRNA-seq: a method for high-throughput profiling and quantifying small RNAs. Genome Biol. 2018;19:113.","journal-title":"Genome Biol"},{"key":"8198_CR31","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.","journal-title":"Nucleic Acids Res"},{"key":"8198_CR32","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","volume":"13","author":"J Cox","year":"2014","unstructured":"Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M. Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed maxLFQ. Mol Cell Proteom. 2014;13:2513\u201326.","journal-title":"Mol Cell Proteom"},{"key":"8198_CR33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature10098","volume":"473","author":"B Schwanh\u00e4usser","year":"2011","unstructured":"Schwanh\u00e4usser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, Chen W, Selbach M. Global quantification of mammalian gene expression control. Nature. 2011;473:337\u201342.","journal-title":"Nature"},{"key":"8198_CR34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.66.13.24","volume":"66","author":"AP Nair","year":"2025","unstructured":"Nair AP, Tejwani S, Dinakaran S, Shetty N, Shetty R, Ghosh A, Sethu S. Elevated neurodegeneration markers in the aqueous humor of primary open angle and normal tension glaucoma patients correlate with disease severity. Invest Ophthalmol Vis Sci. 2025;66:24.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8198_CR35","doi-asserted-by":"publisher","first-page":"128438","DOI":"10.1016\/j.talanta.2025.128438","volume":"296","author":"E Povedano","year":"2026","unstructured":"Povedano E, Rejas-Gonz\u00e1lez R, Montero-Calle A, Ar\u00e9valo B, Valverde A, Salvador NP, Crespo Carball\u00e9s MJ, S\u00e1nchez-Naves J, Pingarr\u00f3n JM, Barderas R, et al. Electrochemical immunosensing for rapid glaucoma disease diagnosis through simultaneous determination of SPP1 and GAS6 proteins in ocular fluids. Talanta. 2026;296:128438.","journal-title":"Talanta"},{"key":"8198_CR36","doi-asserted-by":"publisher","first-page":"eaba5714","DOI":"10.1126\/sciadv.aba5714","volume":"6","author":"Y Vinik","year":"2020","unstructured":"Vinik Y, Ortega FG, Mills GB, Lu Y, Jurkowicz M, Halperin S, Aharoni M, Gutman M, Lev S. Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response. Sci Adv. 2020;6:eaba5714.","journal-title":"Sci Adv"},{"key":"8198_CR37","doi-asserted-by":"publisher","first-page":"105605","DOI":"10.1016\/j.ebiom.2025.105605","volume":"113","author":"J Chen","year":"2025","unstructured":"Chen J, Tian C, Xiong X, Yang Y, Zhang J. Extracellular vesicles: New horizons in neurodegeneration. EBioMedicine. 2025;113:105605.","journal-title":"EBioMedicine"},{"key":"8198_CR38","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3233\/JPD-223481","volume":"14","author":"A Chrysou","year":"2024","unstructured":"Chrysou A, Heikka T, van der Zee S, Boertien JM, Jansonius NM, van Laar T. Reduced thickness of the retina in de novo Parkinson\u2019s Disease shows a distinct pattern, different from Glaucoma. J Parkinson Dis. 2024;14:507\u201319.","journal-title":"J Parkinson Dis"},{"key":"8198_CR39","doi-asserted-by":"publisher","first-page":"13853","DOI":"10.1021\/acsnano.9b04397","volume":"13","author":"G Morad","year":"2019","unstructured":"Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park T-E, Ingber DE, Daisy CC, Moses MA. Tumor-derived extracellular vesicles breach the intact blood\u2013brain barrier via transcytosis. ACS Nano. 2019;13:13853\u201365.","journal-title":"ACS Nano"},{"key":"8198_CR40","first-page":"2242","volume":"40","author":"RS Harwerth","year":"1999","unstructured":"Harwerth RS, Carter-Dawson L, Shen F, Smith EL, Crawford M. Ganglion cell losses underlying visual field defects from experimental glaucoma. Invest ophthalmol Visual Sci. 1999;40:2242\u201350.","journal-title":"Invest ophthalmol Visual Sci"},{"key":"8198_CR41","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1038\/s41591-022-02075-9","volume":"28","author":"K Horie","year":"2022","unstructured":"Horie K, Barth\u00e9lemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM. CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. Nat Med. 2022;28:2547\u201354.","journal-title":"Nat Med"},{"key":"8198_CR42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E. Tau in physiology and pathology. Nat Rev Neurosci. 2016;17:22\u201335.","journal-title":"Nat Rev Neurosci"},{"key":"8198_CR43","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA. Reactive astrocytes: production, function, and therapeutic potential. Immunity. 2017;46:957\u201367.","journal-title":"Immunity"},{"key":"8198_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12974-025-03482-8","volume":"22","author":"C Guan","year":"2025","unstructured":"Guan C, Zhang L, Fomo KN, Yang J, Pfeiffer N, Grus FH. Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection. J Neuroinflamm. 2025;22:159.","journal-title":"J Neuroinflamm"},{"key":"8198_CR45","doi-asserted-by":"publisher","first-page":"eadi4386","DOI":"10.1126\/sciadv.adi4386","volume":"9","author":"MM Barnett","year":"2023","unstructured":"Barnett MM, Reay WR, Geaghan MP, Kiltschewskij DJ, Green MJ, Weidenhofer J, Glatt SJ, Cairns MJ. miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease. Sci Adv. 2023;9:eadi4386.","journal-title":"Sci Adv"},{"key":"8198_CR46","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1242\/dev.144337","volume":"144","author":"M Rajman","year":"2017","unstructured":"Rajman M, Schratt G. MicroRNAs in neural development: from master regulators to fine-tuners. Development. 2017;144:2310\u201322.","journal-title":"Development"},{"key":"8198_CR47","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s12035-019-01717-3","volume":"57","author":"SA Banks","year":"2020","unstructured":"Banks SA, Pierce ML, Soukup GA. Sensational microRNAs: neurosensory roles of the microRNA-183 family. Mol Neurobiol. 2020;57:358\u201371.","journal-title":"Mol Neurobiol"},{"key":"8198_CR48","doi-asserted-by":"crossref","first-page":"E507","DOI":"10.1073\/pnas.1210457110","volume":"110","author":"S Lumayag","year":"2013","unstructured":"Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D. Inactivation of the microRNA-183\/96\/182 cluster results in syndromic retinal degeneration. P Natl Sci. 2013;110:E507\u201316.","journal-title":"P Natl Sci"},{"key":"8198_CR49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12974-024-03162-z","volume":"21","author":"C Song","year":"2024","unstructured":"Song C, Li S, Mai Y, Li L, Dai G, Zhou Y, Liang X, Zou OM, Wang Y, Zhou L. Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology. J Neuroinflamm. 2024;21:167.","journal-title":"J Neuroinflamm"},{"key":"8198_CR50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainresbull.2022.11.007","volume":"192","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Su Q, Xia W, Jia K, Meng D, Wang X, Ni X, Su Z. MiR-140\u20133p directly targets Tyro3 to regulate OGD\/R-induced neuronal injury through the PI3K\/Akt pathway. Brain Res Bull. 2023;192:93\u2013106.","journal-title":"Brain Res Bull"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08198-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08198-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08198-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:04:31Z","timestamp":1781748271000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08198-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8198"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08198-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol received approval from the Medical Ethics Committee of the Eye Hospital of Wenzhou Medical University (Approval No.: 2023-126-K-101-02) and adhered to the principles outlined in the Declaration of Helsinki. Informed consent was obtained from the subject. All animal experiments in our research were conducted in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research and approved by the Animal Care and Use Committee of Wenzhou Medical University (approval No. wydw2022-0115).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have consented to the publication of the research findings.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"778"}}