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All animal experimental protocols were approved by the First Hospital of Lanzhou University Ethics Committee (Number: LDYYLL-2024-681).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Zhou Chen, Yan Wang and Yunjiu Gou conceived the idea and designed the experiments; Zhou Chen, Dacheng Jin, Hu Wang and Qizhou Bai led the experiments; Zhou Chen and Dacheng Jin contributed to data analysis and interpretation; Zhou Chen wrote the paper; Yunjiu Gou and Yan Wang supervised the entire project. All authors read and approved the final manuscript. The authors declare no conflict of interest. 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