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All participants provided written informed consent in compliance with the Declaration of Helsinki. Animal experiments were performed in compliance with institutional guidelines. The study protocol was reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of Shanghai Yishang Biotechnology Co., Ltd. (Approval No. IACUC-2025-NI-055).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication was obtained as part of the informed consent process approved by the Ethics Committee of Shanghai Sixth People\u2019s Hospital (Approval No. 2025-KY-010[K]). All participants provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"885"}}