{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:37:49Z","timestamp":1794011869858,"version":"4.8.0"},"reference-count":224,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traditionally viewed as a localized \u201cwear-and-tear\u201d pathology, osteoarthritis (OA) is now increasingly recognized as a complex systemic disorder driven by metabolic and inflammatory dysregulation. This review synthesizes emerging evidence to redefine the pathogenesis of OA from a \u201cwhole-joint\u201d to a \u201cwhole-body\u201d perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>We first examine local degradation mechanisms, identifying synovial macrophage polarization, mitochondrial dysfunction, and autophagy defects as critical drivers of a pro-inflammatory milieu. Furthermore, we elucidate the mechanism of inflammatory \u201cspillover,\u201d wherein intra-articular cytokines (e.g. IL-1\u03b2, TNF-\u03b1) and extracellular vesicles (EVs) enter the circulation, contributing to a state of low-grade systemic inflammation. This systemic inflammatory burden is closely associated with a cascade of comorbidities, including endothelial dysfunction and atherosclerosis potentially mediated by shared mechanisms such as the \u201cbone-vascular axis,\u201d sarcopenia through the pain-disuse cycle, and central sensitization coupled with HPA axis dysregulation. Conversely, systemic metabolic disorders, particularly obesity-induced \u201cmetaflammation\u201d and insulin resistance, exacerbate joint degeneration through adipokines (e.g. leptin, resistin), forming a vicious bidirectional cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We conclude by discussing how this systemic paradigm necessitates a shift in therapeutic strategies, moving from symptomatic management to holistic interventions. These include targeting metabolic pathways (e.g. metformin), clearing senescent cells (senolytics), and adopting a multidisciplinary precision medicine approach based on inflammatory and metabolic phenotyping.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-026-08277-w","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:35:04Z","timestamp":1779726904000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation"],"prefix":"10.1186","volume":"24","author":[{"given":"Jing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongkai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0322-878X","authenticated-orcid":false,"given":"Bin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"issue":"6","key":"8277_CR1","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1001\/jama.2020.22171","volume":"325","author":"JN Katz","year":"2021","unstructured":"Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021, Feb, 9;325(6):568\u201378. https:\/\/doi.org\/10.1001\/jama.2020.22171.","journal-title":"JAMA"},{"issue":"7","key":"8277_CR2","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","volume":"73","author":"M Cross","year":"2014","unstructured":"Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheumatic Dis. 2014, July;73(7):1323\u201330. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204763.","journal-title":"Ann Rheumatic Dis"},{"issue":"24","key":"8277_CR3","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.1016\/j.cell.2021.11.003","volume":"184","author":"CG Boer","year":"2021","unstructured":"Boer CG, Hatzikotoulas K, Southam L, Stef\u00e1nsd\u00f3ttir L, Zhang Y, Coutinho de Almeida R, et al. Deciphering osteoarthritis genetics across 826, 690 individuals from 9 populations. Cell. 2021, Nov, 24;184(24):6003\u201305. https:\/\/doi.org\/10.1016\/j.cell.2021.11.003.","journal-title":"Cell"},{"key":"8277_CR4","doi-asserted-by":"publisher","first-page":"145619","DOI":"10.1016\/j.gene.2021.145619","volume":"785","author":"V Arora","year":"2021","unstructured":"Arora V, Singh G, O-Sullivan I, Ma K, Natarajan Anbazhagan A, Votta-Velis EG, et al. Gut-microbiota modulation: the impact of thegut-microbiotaon osteoarthritis. Gene. 2021, June, 15;785:145619. https:\/\/doi.org\/10.1016\/j.gene.2021.145619.","journal-title":"Gene"},{"issue":"9","key":"8277_CR5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41584-024-01126-4","volume":"20","author":"A Mobasheri","year":"2024","unstructured":"Mobasheri A, Loeser R. Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development. Nat Rev Rheumatol. 2024, Sept;20(9):525\u201326. https:\/\/doi.org\/10.1038\/s41584-024-01126-4.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"8277_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1186\/s13018-025-06134-y","volume":"20","author":"X Zhang","year":"2025","unstructured":"Zhang X, Shi K, Ruan A, Chen P, Zhang T, Wang Q. Expression characteristics of miR-502-5p\/p53\/NF-\u03baB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodological limitations. J Orthop Surg Res. 2025, Aug, 20;20(1):781. https:\/\/doi.org\/10.1186\/s13018-025-06134-y.","journal-title":"J Orthop Surg Res"},{"key":"8277_CR7","doi-asserted-by":"publisher","first-page":"1633334","DOI":"10.3389\/fimmu.2025.1633334","volume":"16","author":"H Lee","year":"2025","unstructured":"Lee H, Han SJ, Ok S, Lee KM, Choi S, Yoon I, et al. A novel carboxamide bromodomain inhibitor attenuates osteoarthritis via epigenetic repression of NF-\u03baB and MAPK signaling. Front Immunol. 2025;16:1633334. https:\/\/doi.org\/10.3389\/fimmu.2025.1633334.","journal-title":"Front Immunol"},{"key":"8277_CR8","doi-asserted-by":"publisher","first-page":"117453","DOI":"10.1016\/j.taap.2025.117453","volume":"502","author":"Y Wang","year":"2025","unstructured":"Wang Y, Ji J, Abudukeremu A, Ma D, Yin Z, Xu K, et al. Deguelin inhibits IL-1\u03b2-induced chondrocyte inflammation in vitro and ameliorates murine osteoarthritis in vivo. Toxicol Appl Pharm. 2025, Sept;502:117453. https:\/\/doi.org\/10.1016\/j.taap.2025.117453.","journal-title":"Toxicol Appl Pharm"},{"key":"8277_CR9","doi-asserted-by":"publisher","first-page":"115296","DOI":"10.1016\/j.intimp.2025.115296","volume":"163","author":"J Li","year":"2025","unstructured":"Li J, Zeng Y, Wang S, Chen X, Huang H, Gan X, et al. CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways. Int Immunopharmacol. 2025, July, 31;163:115296. https:\/\/doi.org\/10.1016\/j.intimp.2025.115296.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"8277_CR10","doi-asserted-by":"publisher","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","volume":"2","author":"J Martel-Pelletier","year":"2016","unstructured":"Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, et al. Osteoarthritis. Nat Rev Dis Primers. 2016, Oct, 13;2(1):16072. https:\/\/doi.org\/10.1038\/nrdp.2016.72.","journal-title":"Nat Rev Dis Primers"},{"issue":"17","key":"8277_CR11","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.3390\/jcm14175931","volume":"14","author":"S Rusac-Kuki\u0107","year":"2025","unstructured":"Rusac-Kuki\u0107 S, Vi\u0161ni\u0107 A, Vidakovi\u0107 MR, Bobek D. Serum levels of HMGB1, hS100A8\/A9, and sRAGE in patients with knee and hip osteoarthritis: inflammatory biomarkers of disease activity. JCM. 2025, Aug, 22;14(17):5931. https:\/\/doi.org\/10.3390\/jcm14175931.","journal-title":"JCM"},{"issue":"5","key":"8277_CR12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.joca.2020.01.011","volume":"28","author":"Y Wang","year":"2020","unstructured":"Wang Y, Zhao X, Liu-Bryan R. Role of TLR2 and TLR4 in regulation of articular chondrocyte homeostasis. Osteoarthr Cartil. 2020, May;28(5):669\u201374. https:\/\/doi.org\/10.1016\/j.joca.2020.01.011.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"8277_CR13","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s10020-025-01335-x","volume":"31","author":"L Yu","year":"2025","unstructured":"Yu L, Su Z, Tian D, Liu S, Zhang L, Wang Z, et al. Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis. Mol Med. 2025, Aug, 2;31(1):272. https:\/\/doi.org\/10.1186\/s10020-025-01335-x.","journal-title":"Mol Med"},{"issue":"7","key":"8277_CR14","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.17305\/bb.2024.11437","volume":"25","author":"D Zhao","year":"2025","unstructured":"Zhao D, Xing S, Qi J, Wei Z, Huang J, Sun J, et al. Alleviating the IL-1\u03b2-stimulated extracellular matrix degradation in osteoarthritis, and chondrocyte inflammation by morinda officinalis polysaccharide via the SIRT6\/NF-\u03baB pathway. Biomol Biomed. 2025, May, 8;25(7):1610\u201320. https:\/\/doi.org\/10.17305\/bb.2024.11437.","journal-title":"Biomol Biomed"},{"issue":"195","key":"8277_CR15","doi-asserted-by":"publisher","first-page":"685","DOI":"10.24976\/Discov.Med.202537195.59","volume":"37","author":"J Tie","year":"2025","unstructured":"Tie J, Guo J, Yuan J, Wang J. Sirtuin1 promotes the migration of cells and reduces the accumulation of extracellular matrix in trabecular meshwork cells induced by transform growth factor-\u03b2 via smads system. Discov Med. 2025, Apr;37(195):685\u201394. https:\/\/doi.org\/10.24976\/Discov.Med.202537195.59.","journal-title":"Discov Med"},{"issue":"Pt 3","key":"8277_CR16","doi-asserted-by":"publisher","first-page":"146900","DOI":"10.1016\/j.ijbiomac.2025.146900","volume":"322","author":"Q Li","year":"2025","unstructured":"Li Q, Gu H, Song K, Kong X, Li Y, Liu Z, et al. Lentinan rewrites extracellular matrix homeostasis by activating mitophagy via mTOR\/PINK1\/parkin pathway in cartilage to alleviating osteoarthritis. Int J Biol Macromolecules. 2025, Aug, 15;322(Pt 3):146900. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.146900.","journal-title":"Int J Biol Macromolecules"},{"key":"8277_CR17","doi-asserted-by":"publisher","unstructured":"Han Y, Cheng F, Li X, Yu J, Li G, Chen W, et al. The mechanosensitive ion channel Piezo1 regulates chondrocyte homeostasis through the PI3K\/AKT\/mTORC1 pathway in osteoarthritis. J Cellular Mol Medi. 2025, Aug;29(15):e70734. https:\/\/doi.org\/10.1111\/jcmm.70734.","DOI":"10.1111\/jcmm.70734"},{"issue":"9","key":"8277_CR18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","volume":"16","author":"LAJ O\u2019Neill","year":"2016","unstructured":"O\u2019Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016, Sept;16(9):553\u201365. https:\/\/doi.org\/10.1038\/nri.2016.70.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"8277_CR19","doi-asserted-by":"publisher","first-page":"30288","DOI":"10.1038\/s41598-025-16078-2","volume":"15","author":"S Semenistaja","year":"2025","unstructured":"Semenistaja S, Sokolovska L, Svirskis S, Studers P, Groma V, Skuja S. Distinct late-stage osteoarthritis profiles identified through NF-\u03baB, TNF-\u03b1, and TGF-\u03b2\u2013driven synovial inflammation and pain. Sci Rep. 2025, Aug, 19;15(1):30288. https:\/\/doi.org\/10.1038\/s41598-025-16078-2.","journal-title":"Sci Rep"},{"issue":"3","key":"8277_CR20","doi-asserted-by":"publisher","first-page":"100653","DOI":"10.1016\/j.ocarto.2025.100653","volume":"7","author":"V Kreutzinger","year":"2025","unstructured":"Kreutzinger V, Ziegeler K, Joseph GB, Lynch JA, Akkaya Z, Lane NE, et al. Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis \u2013 4-year follow-up data from the osteoarthritis initiative. Osteoarthr Cartil Open. 2025, Sept;7(3):100653. https:\/\/doi.org\/10.1016\/j.ocarto.2025.100653.","journal-title":"Osteoarthr Cartil Open"},{"issue":"11","key":"8277_CR21","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1007\/s00256-025-04908-3","volume":"54","author":"D Hayashi","year":"2025","unstructured":"Hayashi D, Tu K, Roemer FW, Guermazi A. Recent evolution in imaging techniques for assessment of synovitis in osteoarthritis. Skeletal Radiol. 2025, Nov;54(11):2329\u201338. https:\/\/doi.org\/10.1007\/s00256-025-04908-3.","journal-title":"Skeletal Radiol"},{"issue":"1","key":"8277_CR22","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41598-018-36909-9","volume":"9","author":"AR Sun","year":"2019","unstructured":"Sun AR, Wu X, Liu B, Chen Y, Armitage CW, Kollipara A, et al. Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation. Sci Rep. 2019, Jan, 23;9(1):426. https:\/\/doi.org\/10.1038\/s41598-018-36909-9.","journal-title":"Sci Rep"},{"key":"8277_CR23","doi-asserted-by":"publisher","first-page":"1327852","DOI":"10.3389\/fimmu.2023.1327852","volume":"14","author":"D Jiang","year":"2024","unstructured":"Jiang D, Guo J, Liu Y, Li W, Lu D. Glycolysis: an emerging regulator of osteoarthritis. Front Immunol. 2024, Jan, 9;14:1327852. https:\/\/doi.org\/10.3389\/fimmu.2023.1327852.","journal-title":"Front Immunol"},{"issue":"5","key":"8277_CR24","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.14336\/AD.2019.1127","volume":"11","author":"S An","year":"2020","unstructured":"An S, Hu H, Li Y, Hu Y. Pyroptosis plays a role in osteoarthritis. Aging Disease. 2020, Oct;11(5):1146\u201357. https:\/\/doi.org\/10.14336\/AD.2019.1127.","journal-title":"Aging Disease"},{"issue":"1","key":"8277_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13075-025-03573-0","volume":"27","author":"X Du","year":"2025","unstructured":"Du X, Liu R, Jiang Z, Zhang C, Yang Z, Hu S, et al. Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1. Arthritis Res Ther. 2025, May, 15;27(1):104. https:\/\/doi.org\/10.1186\/s13075-025-03573-0.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"8277_CR26","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3390\/biom15060874","volume":"15","author":"M Alad","year":"2025","unstructured":"Alad M, Yousef F, Epure LM, Lui A, Grant MP, Merle G, et al. Unraveling osteoarthritis: mechanistic insights and emerging therapies targeting pain and inflammation. Biomolecules. 2025, June, 16;15(6):874. https:\/\/doi.org\/10.3390\/biom15060874.","journal-title":"Biomolecules"},{"key":"8277_CR27","doi-asserted-by":"publisher","first-page":"115472","DOI":"10.1016\/j.intimp.2025.115472","volume":"165","author":"Z Shen","year":"2025","unstructured":"Shen Z, Chen H, Wang S, Yu T, Yang Z, Huang H, et al. Dimethyl fumarate mitigates osteoarthritis progression through Nrf2 activation-mediated suppression of oxidative stress and subchondral osteoclastogenesis. Int Immunopharmacol. 2025, Nov, 14;165:115472. https:\/\/doi.org\/10.1016\/j.intimp.2025.115472.","journal-title":"Int Immunopharmacol"},{"key":"8277_CR28","doi-asserted-by":"publisher","first-page":"109948","DOI":"10.1016\/j.cellsig.2021.109948","volume":"82","author":"R Sohn","year":"2021","unstructured":"Sohn R, R\u00f6sch G, Junker M, Meurer A, Zaucke F, Jenei-Lanzl Z. Adrenergic signalling in osteoarthritis. Cellular Signalling. 2021, June;82:109948. https:\/\/doi.org\/10.1016\/j.cellsig.2021.109948.","journal-title":"Cellular Signalling"},{"issue":"17","key":"8277_CR29","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.3390\/cells11172760","volume":"11","author":"Q Sun","year":"2022","unstructured":"Sun Q, Zhang Y, Ding Y, Xie W, Li H, Li S, et al. Inhibition of PGE2 in subchondral bone attenuates osteoarthritis. Cells. 2022, Sept, 5;11(17):2760. https:\/\/doi.org\/10.3390\/cells11172760.","journal-title":"Cells"},{"issue":"11","key":"8277_CR30","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1136\/ard.2006.063354","volume":"66","author":"S Suri","year":"2007","unstructured":"Suri S, Gill SE, Massena de Camin S, McWilliams D, Wilson DF, Walsh DA. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheumatic Dis. 2007, Nov;66(11):1423\u201328. https:\/\/doi.org\/10.1136\/ard.2006.063354.","journal-title":"Ann Rheumatic Dis"},{"key":"8277_CR31","doi-asserted-by":"publisher","unstructured":"Su W, Liu G, Liu X, Zhou Y, Sun Q, Zhen G, et al. Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development. JCI Insight. 2020, Apr, 23;5(8):e135446. https:\/\/doi.org\/10.1172\/jci.insight.135446.","DOI":"10.1172\/jci.insight.135446"},{"issue":"7","key":"8277_CR32","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","volume":"8","author":"PI Mapp","year":"2012","unstructured":"Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012, May, 29;8(7):390\u201398. https:\/\/doi.org\/10.1038\/nrrheum.2012.80.","journal-title":"Nat Rev Rheumatol"},{"key":"8277_CR33","doi-asserted-by":"publisher","first-page":"1047943","DOI":"10.3389\/fendo.2022.1047943","volume":"13","author":"M Morgan","year":"2022","unstructured":"Morgan M, Nazemian V, Harrington K, Ivanusic JJ. Mini review: the role of sensory innervation to subchondral bone in osteoarthritis pain. Front. Endocrinol. 2022;13:1047943. https:\/\/doi.org\/10.3389\/fendo.2022.1047943.","journal-title":"Front. Endocrinol"},{"issue":"9","key":"8277_CR34","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.joca.2020.05.010","volume":"28","author":"K Aso","year":"2020","unstructured":"Aso K, Shahtaheri SM, Hill R, Wilson D, McWilliams DF, Nwosu LN, et al. Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats. Osteoarthr Cartil. 2020, Sept;28(9):1245\u201354. https:\/\/doi.org\/10.1016\/j.joca.2020.05.010.","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"8277_CR35","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41584-025-01280-3","volume":"21","author":"V Batchelor","year":"2025","unstructured":"Batchelor V, Perry TA, Cader MZ, Vincent TL. Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain. Nat Rev Rheumatol. 2025, Sept;21(9):526\u201345. https:\/\/doi.org\/10.1038\/s41584-025-01280-3.","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"8277_CR36","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/j.pain.0000000000002355","volume":"163","author":"M Morgan","year":"2022","unstructured":"Morgan M, Thai J, Nazemian V, Song R, Ivanusic JJ. Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis. Pain. 2022, Feb, 1;163(2):390\u2013402. https:\/\/doi.org\/10.1097\/j.pain.0000000000002355.","journal-title":"Pain"},{"issue":"25","key":"8277_CR37","first-page":"01165","volume":"S1063-4584","author":"J Ivanusic","year":"2025","unstructured":"Ivanusic J, Imlach W, Thai J, Bos J, Hart J, Fuller-Jackson JP. Loss of peptidergic innervation of the subchondral bone in a murine model of MIA-induced osteoarthritis. Osteoarthr Cartil. 2025, Oct, 4;S1063-4584(25):01165\u20133.","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"8277_CR38","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/ijms18050931","volume":"18","author":"S Gr\u00e4ssel","year":"2017","unstructured":"Gr\u00e4ssel S, Muschter D. Peripheral nerve fibers and their neurotransmitters in osteoarthritis pathology. IJMS. 2017, Apr, 28;18(5):931. https:\/\/doi.org\/10.3390\/ijms18050931.","journal-title":"IJMS"},{"issue":"1","key":"8277_CR39","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13287-025-04155-2","volume":"16","author":"S St\u00f6ckl","year":"2025","unstructured":"St\u00f6ckl S, Taheri S, Maier V, Asid A, Toelge M, Clausen-Schaumann H, et al. Effects of intra-articular applied rat BMSCs expressing alpha-calcitonin gene-related peptide or substance P on osteoarthritis pathogenesis in a murine surgical osteoarthritis model. STEM Cell Res Ther. 2025, Mar, 5;16(1):117. https:\/\/doi.org\/10.1186\/s13287-025-04155-2.","journal-title":"STEM Cell Res Ther"},{"issue":"1","key":"8277_CR40","doi-asserted-by":"publisher","first-page":"8861347","DOI":"10.1155\/2020\/8861347","volume":"2020","author":"M Li","year":"2020","unstructured":"Li M, Xie WQ, He M, Yu DJ, Xu DQ, Xiao WF, et al. Characterization of the subchondral bone and pain behavior changes in a novel bipedal standing mouse model of facet joint osteoarthritis. Biomed Res Int. 2020;2020(1):8861347. https:\/\/doi.org\/10.1155\/2020\/8861347.","journal-title":"Biomed Res Int"},{"issue":"5","key":"8277_CR41","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.berh.2018.04.001","volume":"31","author":"A Courties","year":"2017","unstructured":"Courties A, Sellam J, Berenbaum F. Role of the autonomic nervous system in osteoarthritis. Best Pract ResearchClin Rheumatol. 2017, Oct;31(5):661\u201375. https:\/\/doi.org\/10.1016\/j.berh.2018.04.001.","journal-title":"Best Pract ResearchClin Rheumatol"},{"issue":"10182","key":"8277_CR42","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019, Apr, 27;393(10182):1745\u201359. https:\/\/doi.org\/10.1016\/S0140-6736(19)30417-9.","journal-title":"Lancet"},{"issue":"1","key":"8277_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/BOR.0000000000000353","volume":"29","author":"CR Scanzello","year":"2017","unstructured":"Scanzello CR. Role of low-grade inflammation in osteoarthritis. Curr Opin Rheumatol. 2017, Jan;29(1):79\u201385. https:\/\/doi.org\/10.1097\/BOR.0000000000000353.","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"8277_CR44","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.3390\/ijms18061272","volume":"18","author":"A Corrado","year":"2017","unstructured":"Corrado A, Maruotti N, Cantatore FP. Osteoblast role in rheumatic diseases. IJMS. 2017, June, 15;18(6):1272. https:\/\/doi.org\/10.3390\/ijms18061272.","journal-title":"IJMS"},{"issue":"7","key":"8277_CR45","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1002\/art.24598","volume":"60","author":"G Livshits","year":"2009","unstructured":"Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FMK, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the chingford study. Arthritis Rheumatism. 2009, July;60(7):2037\u201345. https:\/\/doi.org\/10.1002\/art.24598.","journal-title":"Arthritis Rheumatism"},{"key":"8277_CR46","doi-asserted-by":"publisher","unstructured":"Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther. 2006, 8 Suppl 2(Suppl 2): 8(Suppl 2):S3. https:\/\/doi.org\/10.1186\/ar1917.","DOI":"10.1186\/ar1917"},{"key":"8277_CR47","doi-asserted-by":"publisher","unstructured":"Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, et al. Exosomes from IL-1\u03b2 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther. 2014, Aug, 4;16(4):R163. https:\/\/doi.org\/10.1186\/ar4679.","DOI":"10.1186\/ar4679"},{"key":"8277_CR48","doi-asserted-by":"publisher","first-page":"1027917","DOI":"10.3389\/fmolb.2022.1027917","volume":"9","author":"G Yang","year":"2022","unstructured":"Yang G, Kang HC, Cho YY, Lee HS, Lee JY. Inflammasomes and their roles in arthritic disease pathogenesis. Front Mol Biosci. 2022;9:1027917. https:\/\/doi.org\/10.3389\/fmolb.2022.1027917.","journal-title":"Front Mol Biosci"},{"issue":"2","key":"8277_CR49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/biom15020231","volume":"15","author":"M Malaguarnera","year":"2025","unstructured":"Malaguarnera M, Cauli O, Cabrera-Pastor A. Obesity and adipose-derived extracellular vesicles: implications for metabolic regulation and disease. Biomolecules. 2025, Feb, 5;15(2):231. https:\/\/doi.org\/10.3390\/biom15020231.","journal-title":"Biomolecules"},{"key":"8277_CR50","doi-asserted-by":"publisher","first-page":"1674028","DOI":"10.3389\/fendo.2025.1674028","volume":"16","author":"S Liu","year":"2025","unstructured":"Liu S, Pan Z, Chen X, Wang Z, Zhong W, Ling J, et al. The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects. Front. Endocrinol. 2025, Oct, 7;16:1674028. https:\/\/doi.org\/10.3389\/fendo.2025.1674028.","journal-title":"Front. Endocrinol"},{"key":"8277_CR51","doi-asserted-by":"publisher","first-page":"111263","DOI":"10.1016\/j.mad.2020.111263","volume":"189","author":"R Wallis","year":"2020","unstructured":"Wallis R, Mizen H, Bishop CL. The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype. Mechanisms Ageing Devel. 2020, July;189:111263. https:\/\/doi.org\/10.1016\/j.mad.2020.111263.","journal-title":"Mechanisms Ageing Devel"},{"key":"8277_CR52","doi-asserted-by":"publisher","first-page":"1549833","DOI":"10.3389\/fimmu.2025.1549833","volume":"16","author":"P Chen","year":"2025","unstructured":"Chen P, Zeng L, Wang T, He J, Xiong S, Chen G, et al. The communication role of extracellular vesicles in the osteoarthritis microenvironment. Front Immunol. 2025, Mar, 17;16:1549833. https:\/\/doi.org\/10.3389\/fimmu.2025.1549833.","journal-title":"Front Immunol"},{"issue":"12","key":"8277_CR53","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrrheum.2012.135","volume":"8","author":"Q Zhuo","year":"2012","unstructured":"Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012, Dec;8(12):729\u201337. https:\/\/doi.org\/10.1038\/nrrheum.2012.135.","journal-title":"Nat Rev Rheumatol"},{"key":"8277_CR54","doi-asserted-by":"publisher","unstructured":"Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Geron Biol Sci Med Sci. 2014, June, 1;69(Suppl 1):S4\u20139. https:\/\/doi.org\/10.1093\/gerona\/glu057.","DOI":"10.1093\/gerona\/glu057"},{"issue":"3","key":"8277_CR55","doi-asserted-by":"publisher","first-page":"319","DOI":"10.5312\/wjo.v5.i3.319","volume":"5","author":"T Poonpet","year":"2014","unstructured":"Poonpet T. Adipokines: biomarkers for osteoarthritis? WJO. 2014, July, 18;5(3):319\u201327. https:\/\/doi.org\/10.5312\/wjo.v5.i3.319.","journal-title":"WJO"},{"key":"8277_CR56","doi-asserted-by":"publisher","unstructured":"Yan M, Zhang J, Yang H, Sun Y. The role of leptin in osteoarthritis. Med (Baltim). 2018, Apr;97(14):e 0257. https:\/\/doi.org\/10.1097\/MD.0000000000010257.","DOI":"10.1097\/MD.0000000000010257"},{"issue":"1","key":"8277_CR57","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/BOR.0000000000000681","volume":"32","author":"LJ Favazzo","year":"2020","unstructured":"Favazzo LJ, Hendesi H, Villani DA, Soniwala S, Dar QA, Schott EM, et al. The gut microbiome-joint connection: implications in osteoarthritis. Curr Opin Rheumatol. 2020, Jan;32(1):92\u2013101. https:\/\/doi.org\/10.1097\/BOR.0000000000000681.","journal-title":"Curr Opin Rheumatol"},{"key":"8277_CR58","doi-asserted-by":"publisher","first-page":"1605860","DOI":"10.3389\/fcimb.2025.1605860","volume":"15","author":"N Sun","year":"2025","unstructured":"Sun N, Zhao Y, Zhang A, He Y. Gut microbiota and osteoarthritis: epidemiology, mechanistic analysis, and new horizons for pharmacological interventions. Front Cell Infect Microbiol. 2025, July, 16;15:1605860. https:\/\/doi.org\/10.3389\/fcimb.2025.1605860.","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"8277_CR59","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/rheumatology\/keu464","volume":"54","author":"E Thijssen","year":"2015","unstructured":"Thijssen E, van Caam A, van der Kraan PM. Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatol (Oxford). 2015, Apr;54(4):588\u2013600. https:\/\/doi.org\/10.1093\/rheumatology\/keu464.","journal-title":"Rheumatol (Oxford)"},{"issue":"11","key":"8277_CR60","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.3390\/ijms24119352","volume":"24","author":"P Gonz\u00e1lez","year":"2023","unstructured":"Gonz\u00e1lez P, Lozano P, Ros G, Solano F. Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. IJMS. 2023, May, 27;24(11):9352. https:\/\/doi.org\/10.3390\/ijms24119352.","journal-title":"IJMS"},{"issue":"4","key":"8277_CR61","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.joca.2015.10.017","volume":"24","author":"M Ribeiro","year":"2016","unstructured":"Ribeiro M, L\u00f3pez de Figueroa P, Blanco FJ, Mendes AF, Caram\u00e9s B. Insulin decreases autophagy and leads to cartilage degradation. Osteoarthr Cartil. 2016, Apr;24(4):731\u201339. https:\/\/doi.org\/10.1016\/j.joca.2015.10.017.","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"8277_CR62","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/19476035231194771","volume":"15","author":"W Xu","year":"2024","unstructured":"Xu W, Wang J, Cui L, Huang C, Xia N, Xie M, et al. Il-1\u03b2 promotes superficial zone cells senescence in articular cartilage by inhibiting autophagy. Cartilage. 2024, Dec;15(4):428\u201339. https:\/\/doi.org\/10.1177\/19476035231194771.","journal-title":"Cartilage"},{"key":"8277_CR63","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bone.2016.01.019","volume":"85","author":"M Rahmati","year":"2016","unstructured":"Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone. 2016, Apr;85:81\u201390. https:\/\/doi.org\/10.1016\/j.bone.2016.01.019.","journal-title":"Bone"},{"issue":"1","key":"8277_CR64","doi-asserted-by":"publisher","first-page":"20220747","DOI":"10.1515\/biol-2022-0747","volume":"18","author":"J Xiao","year":"2023","unstructured":"Xiao J, Zhang P, Cai FL, Luo CG, Pu T, Pan XL, et al. IL-17 in osteoarthritis: a narrative review. Open Life Sci. 2023;18(1):20220747. https:\/\/doi.org\/10.1515\/biol-2022-0747.","journal-title":"Open Life Sci"},{"issue":"1","key":"8277_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/os.14302","volume":"17","author":"X Zou","year":"2025","unstructured":"Zou X, Xu H, Qian W. Macrophage polarization in the osteoarthritis pathogenesis and treatment. Orthop Surg. 2025, Jan;17(1):22\u201335. https:\/\/doi.org\/10.1111\/os.14302.","journal-title":"Orthop Surg"},{"key":"8277_CR66","doi-asserted-by":"publisher","first-page":"1393418","DOI":"10.3389\/fimmu.2024.1393418","volume":"15","author":"Z Wen","year":"2024","unstructured":"Wen Z, Qiu L, Ye Z, Tan X, Xu X, Lu M, et al. The role of th\/treg immune cells in osteoarthritis. Front Immunol. 2024;15:1393418. https:\/\/doi.org\/10.3389\/fimmu.2024.1393418.","journal-title":"Front Immunol"},{"issue":"1","key":"8277_CR67","doi-asserted-by":"publisher","first-page":"650","DOI":"10.4049\/jimmunol.166.1.650","volume":"166","author":"K Shi","year":"2001","unstructured":"Shi K, Hayashida K, Kaneko M, Hashimoto J, Tomita T, Lipsky PE, et al. Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol. 2001, Jan, 1;166(1):650\u201355. https:\/\/doi.org\/10.4049\/jimmunol.166.1.650.","journal-title":"J Immunol"},{"issue":"11","key":"8277_CR68","first-page":"1377","volume":"79","author":"V Krenn","year":"1999","unstructured":"Krenn V, Hensel F, Kim HJ, Souto Carneiro MM, Starostik P, Ristow G, et al. Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response. Lab Invest. 1999, Nov;79(11):1377\u201384.","journal-title":"Lab Invest"},{"issue":"17","key":"8277_CR69","doi-asserted-by":"publisher","first-page":"8742","DOI":"10.3390\/ijms26178742","volume":"26","author":"MO Korovina","year":"2025","unstructured":"Korovina MO, Valeeva AR, Akhtyamov IF, Brooks W, Renaudineau Y, Manukyan G, et al. Joint tissues: convergence and divergence of the pathogenetic mechanisms of rheumatoid arthritis and osteoarthritis. IJMS. 2025, Sept, 8;26(17):8742. https:\/\/doi.org\/10.3390\/ijms26178742.","journal-title":"IJMS"},{"key":"8277_CR70","doi-asserted-by":"publisher","first-page":"1159167","DOI":"10.3389\/fgene.2023.1159167","volume":"14","author":"X Han","year":"2023","unstructured":"Han X, Lin D, Huang W, Li D, Li N, Xie X. Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: a review of TCM intervention. Front Genet. 2023;14:1159167. https:\/\/doi.org\/10.3389\/fgene.2023.1159167.","journal-title":"Front Genet"},{"key":"8277_CR71","doi-asserted-by":"publisher","unstructured":"Koskinen A, Vuolteenaho K, Nieminen R, Moilanen T, Moilanen E. 011 Proinflammatory and catabolic role of leptin in osteoarthritis. Correlation with il-6, mmp-1 and mmp-3 in synovial fluid and effects in human oa cartilage. Osteoarthr Cartil. 2010;18(1):S13\u201314. https:\/\/doi.org\/10.1016\/S1063-4584(10)60038-6.","DOI":"10.1016\/S1063-4584(10)60038-6"},{"key":"8277_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/345838","volume":"2009","author":"K Vuolteenaho","year":"2009","unstructured":"Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, P\u00e4iv\u00e4rinta U, Moilanen T, et al. Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage\u2014mediator role of NO in leptin-induced PGE 2, IL-6, and IL-8 production. Mediators Inflammation. 2009;2009:1\u201310. https:\/\/doi.org\/10.1155\/2009\/345838.","journal-title":"Mediators Inflammation"},{"issue":"4","key":"8277_CR73","doi-asserted-by":"publisher","first-page":"100405","DOI":"10.1016\/j.ocarto.2023.100405","volume":"5","author":"TKY Chong","year":"2023","unstructured":"Chong TKY, Tan JR, Ma CA, Wong SBS, Leung YY. Association of adipokines with severity of knee osteoarthritis assessed clinically and on magnetic resonance imaging. Osteoarthr Cartil Open. 2023, Dec;5(4):100405. https:\/\/doi.org\/10.1016\/j.ocarto.2023.100405.","journal-title":"Osteoarthr Cartil Open"},{"issue":"3","key":"8277_CR74","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/jor.21000","volume":"28","author":"R Gandhi","year":"2010","unstructured":"Gandhi R, Takahashi M, Syed K, Davey JR, Mahomed NN. Relationship between body habitus and joint leptin levels in a knee osteoarthritis population. J Orthopaedic Res. 2010, Mar;28(3):329\u201333. https:\/\/doi.org\/10.1002\/jor.21000.","journal-title":"J Orthopaedic Res"},{"issue":"4","key":"8277_CR75","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00296-010-1731-8","volume":"32","author":"Y Duan","year":"2012","unstructured":"Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, et al. Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int. 2012, Apr;32(4):985\u201390. https:\/\/doi.org\/10.1007\/s00296-010-1731-8.","journal-title":"Rheumatol Int"},{"issue":"8","key":"8277_CR76","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/biomedicines9081019","volume":"9","author":"SN Lambova","year":"2021","unstructured":"Lambova SN, Batsalova T, Moten D, Stoyanova S, Georgieva E, Belenska-Todorova L, et al. Serum leptin and resistin levels in knee osteoarthritis\u2014clinical and radiologic links: towards precise definition of metabolic type knee osteoarthritis. Biomedicines. 2021, Aug, 15;9(8):1019. https:\/\/doi.org\/10.3390\/biomedicines9081019.","journal-title":"Biomedicines"},{"issue":"5","key":"8277_CR77","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/annrheumdis-2019-216713","volume":"79","author":"J Li","year":"2020","unstructured":"Li J, Zhang B, Liu WX, Lu K, Pan H, Wang T, et al. Metformin limits osteoarthritis development and progression through activation of AMPK signalling. Ann Rheumatic Dis. 2020, May;79(5):635\u201345. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216713.","journal-title":"Ann Rheumatic Dis"},{"issue":"1","key":"8277_CR78","doi-asserted-by":"publisher","first-page":"20220922","DOI":"10.1515\/biol-2022-0922","volume":"19","author":"T Xu","year":"2024","unstructured":"Xu T, Liu K, Fan J, Jia X, Guo X, Zhao X, et al. Metformin mitigates osteoarthritis progression by modulating the PI3K\/AKT\/mTOR signaling pathway and enhancing chondrocyte autophagy. Open Life Sci. 2024;19(1):20220922. https:\/\/doi.org\/10.1515\/biol-2022-0922.","journal-title":"Open Life Sci"},{"issue":"3","key":"8277_CR79","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3892\/etm.2022.11146","volume":"23","author":"J Yan","year":"2022","unstructured":"Yan J, Ding D, Feng G, Yang Y, Zhou Y, Ma L, et al. Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation. Exp Ther Med. 2022, Mar;23(3):222. https:\/\/doi.org\/10.3892\/etm.2022.11146.","journal-title":"Exp Ther Med"},{"issue":"5","key":"8277_CR80","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.3390\/ijms22052411","volume":"22","author":"A Cordero-Barreal","year":"2021","unstructured":"Cordero-Barreal A, Gonz\u00e1lez-Rodr\u00edguez M, Ruiz-Fern\u00e1ndez C, Eldjoudi DA, AbdElhafez YRF, Lago F, et al. An update on the role of leptin in the immuno-metabolism of cartilage. IJMS. 2021, Feb, 27;22(5):2411. https:\/\/doi.org\/10.3390\/ijms22052411.","journal-title":"IJMS"},{"issue":"19","key":"8277_CR81","doi-asserted-by":"publisher","first-page":"10865","DOI":"10.3390\/ijms251910865","volume":"25","author":"A Economou","year":"2024","unstructured":"Economou A, Mallia I, Fioravanti A, Gentileschi S, Nacci F, Bellando Randone S, et al. The role of adipokines between genders in the pathogenesis of osteoarthritis. IJMS. 2024, Oct, 9;25(19):10865. https:\/\/doi.org\/10.3390\/ijms251910865.","journal-title":"IJMS"},{"issue":"1","key":"8277_CR82","doi-asserted-by":"publisher","first-page":"7264704","DOI":"10.1155\/2024\/7264704","volume":"2024","author":"J Conde-Aranda","year":"2024","unstructured":"Conde-Aranda J, Scotece M, Varela-Garc\u00eda M, Torrijos-Pulp\u00f3n C, Arosa L, Camba-G\u00f3mez M, et al. Lipocalin-2 serum levels in rheumatoid arthritis patients treated with adalimumab and its correlation with proinflammatory factors. Mediators Inflammation. 2024;2024(1):7264704. https:\/\/doi.org\/10.1155\/2024\/7264704.","journal-title":"Mediators Inflammation"},{"key":"8277_CR83","doi-asserted-by":"publisher","unstructured":"Iwata M, Hara K, Kamura Y, Honoki H, Fujisaka S, Ishiki M, et al. Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance. PLoS One. 2018;13(3):e0192609. https:\/\/doi.org\/10.1371\/journal.pone.0192609.","DOI":"10.1371\/journal.pone.0192609"},{"issue":"4","key":"8277_CR84","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/rheumatology\/kev408","volume":"55","author":"J Martel-Pelletier","year":"2016","unstructured":"Martel-Pelletier J, Raynauld JP, Dorais M, Abram F, Pelletier JP. The levels of the adipokines adipsin and leptin are associated with knee osteoarthritis progression as assessed by MRI and incidence of total knee replacement in symptomatic osteoarthritis patients: a post hoc analysis. Rheumatol (Oxford). 2016, Apr;55(4):680\u201388. https:\/\/doi.org\/10.1093\/rheumatology\/kev408.","journal-title":"Rheumatol (Oxford)"},{"key":"8277_CR85","doi-asserted-by":"publisher","first-page":"109187","DOI":"10.1016\/j.clim.2022.109187","volume":"246","author":"R Abdelnaby","year":"2023","unstructured":"Abdelnaby R, Sonbol YT, Dardeer KT, Elgenidy A, Ebrahim MA, Elmenawi KA, et al. Could osteopontin be a useful biomarker in the diagnosis and severity assessment of osteoarthritis? A systematic review and meta-analysis of recent evidence. Clin Immunol. 2023, Jan;246:109187. https:\/\/doi.org\/10.1016\/j.clim.2022.109187.","journal-title":"Clin Immunol"},{"issue":"4","key":"8277_CR86","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00011-020-01326-0","volume":"69","author":"M Scotece","year":"2020","unstructured":"Scotece M, Koskinen-Kolasa A, Pemmari A, Lepp\u00e4nen T, H\u00e4m\u00e4l\u00e4inen M, Moilanen T, et al. Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients. Inflamm Res. 2020, Apr;69(4):415\u201321. https:\/\/doi.org\/10.1007\/s00011-020-01326-0.","journal-title":"Inflamm Res"},{"key":"8277_CR87","doi-asserted-by":"publisher","first-page":"155368","DOI":"10.1016\/j.cyto.2020.155368","volume":"138","author":"BH Sobieh","year":"2021","unstructured":"Sobieh BH, Kassem DH, Zakaria ZM, El-Mesallamy HO. Potential emerging roles of the novel adipokines adipolin\/CTRP12 and meteorin-like\/METRNL in obesity-osteoarthritis interplay. Cytokine. 2021, Feb;138:155368. https:\/\/doi.org\/10.1016\/j.cyto.2020.155368.","journal-title":"Cytokine"},{"key":"8277_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/631251","volume":"2013","author":"L Jiang","year":"2013","unstructured":"Jiang L, Bao J, Zhou X, Xiong Y, Wu L. Increased serum levels and chondrocyte expression of nesfatin-1 in patients with osteoarthritis and its relation with BMI, hsCRP, and IL-18. Mediators Inflammation. 2013;2013:1\u20139. https:\/\/doi.org\/10.1155\/2013\/631251.","journal-title":"Mediators Inflammation"},{"issue":"1","key":"8277_CR89","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cger.2014.08.019","volume":"31","author":"SR Piva","year":"2015","unstructured":"Piva SR, Susko AM, Khoja SS, Josbeno DA, Fitzgerald GK, Toledo FGS. Links between osteoarthritis and diabetes: implications for management from a physical activity perspective. Clinics Geriatric Med. 2015, Feb;31(1):67\u201387, viii. https:\/\/doi.org\/10.1016\/j.cger.2014.08.019.","journal-title":"Clinics Geriatric Med"},{"key":"8277_CR90","doi-asserted-by":"publisher","unstructured":"Louati K, Vidal C, Berenbaum F, Sellam J. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. RMD Open. 2015;1(1):e000077. https:\/\/doi.org\/10.1136\/rmdopen-2015-000077.","DOI":"10.1136\/rmdopen-2015-000077"},{"issue":"6","key":"8277_CR91","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/art.40087","volume":"69","author":"J Niu","year":"2017","unstructured":"Niu J, Clancy M, Aliabadi P, Vasan R, Felson DT. Metabolic syndrome, its components, and knee osteoarthritis: the framingham osteoarthritis study. Arthritis & Rheumatol. 2017, June;69(6):1194\u2013203. https:\/\/doi.org\/10.1002\/art.40087.","journal-title":"Arthritis & Rheumatol"},{"issue":"6","key":"8277_CR92","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/art.39561","volume":"68","author":"D Hamada","year":"2016","unstructured":"Hamada D, Maynard R, Schott E, Drinkwater CJ, Ketz JP, Kates SL, et al. Suppressive effects of insulin on Tumor Necrosis factor\u2013dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus. Arthritis & Rheumatol. 2016, June;68(6):1392\u2013402. https:\/\/doi.org\/10.1002\/art.39561.","journal-title":"Arthritis & Rheumatol"},{"issue":"1","key":"8277_CR93","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/art.21523","volume":"54","author":"MMC Steenvoorden","year":"2006","unstructured":"Steenvoorden MMC, Huizinga TWJ, Verzijl N, Bank RA, Ronday HK, Luning HAF, et al. Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis Rheumatism. 2006, Jan;54(1):253\u201363. https:\/\/doi.org\/10.1002\/art.21523.","journal-title":"Arthritis Rheumatism"},{"issue":"1038","key":"8277_CR94","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1136\/pgmj.2010.146399rep","volume":"88","author":"F Berenbaum","year":"2012","unstructured":"Berenbaum F. Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Postgrad Med J. 2012, Apr;88(1038):240\u201342. https:\/\/doi.org\/10.1136\/pgmj.2010.146399rep.","journal-title":"Postgrad Med J"},{"issue":"9","key":"8277_CR95","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.joca.2015.04.026","volume":"23","author":"MC Laiguillon","year":"2015","unstructured":"Laiguillon MC, Courties A, Houard X, Auclair M, Sautet A, Capeau J, et al. Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis. Osteoarthr Cartil. 2015, Sept;23(9):1513\u201322. https:\/\/doi.org\/10.1016\/j.joca.2015.04.026.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"8277_CR96","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.joca.2018.03.010","volume":"26","author":"J Neumann","year":"2018","unstructured":"Neumann J, Hofmann FC, Heilmeier U, Ashmeik W, Tang K, Gersing AS, et al. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the osteoarthritis initiative. Osteoarthr Cartil. 2018, June;26(6):751\u201361. https:\/\/doi.org\/10.1016\/j.joca.2018.03.010.","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"8277_CR97","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/antiox11040628","volume":"11","author":"M Pi\u00f1eiro-Ramil","year":"2022","unstructured":"Pi\u00f1eiro-Ramil M, Burguera EF, Hermida-G\u00f3mez T, Caram\u00e9s B, Oreiro-Villar N, Meijide-Fa\u00edlde R, et al. Reduced levels of H2S in diabetes-associated osteoarthritis are linked to hyperglycaemia, nrf-2\/HO-1 signalling downregulation and chondrocyte dysfunction. Antioxid (Basel). 2022, Mar, 25;11(4):628. https:\/\/doi.org\/10.3390\/antiox11040628.","journal-title":"Antioxid (Basel)"},{"issue":"2","key":"8277_CR98","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/BOR.0000000000000373","volume":"29","author":"A Courties","year":"2017","unstructured":"Courties A, Sellam J, Berenbaum F. Metabolic syndrome-associated osteoarthritis. Curr Opin Rheumatol. 2017, Mar;29(2):214\u201322. https:\/\/doi.org\/10.1097\/BOR.0000000000000373.","journal-title":"Curr Opin Rheumatol"},{"key":"8277_CR99","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.diabres.2016.10.021","volume":"122","author":"A Courties","year":"2016","unstructured":"Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: what are the links? Diabetes ResearchClin Pr. 2016, Dec;122:198\u2013206. https:\/\/doi.org\/10.1016\/j.diabres.2016.10.021.","journal-title":"Diabetes ResearchClin Pr"},{"key":"8277_CR100","doi-asserted-by":"publisher","unstructured":"Bradley D. The intriguing intersection of type 2 diabetes, obesity-related insulin resistance, and osteoarthritis. J CLIN ENDOCR Metab. 2021, Apr, 23;106(5):e2370\u20132. https:\/\/doi.org\/10.1210\/clinem\/dgab009.","DOI":"10.1210\/clinem\/dgab009"},{"issue":"16","key":"8277_CR101","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"KGMM Alberti","year":"2009","unstructured":"Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009, Oct, 20;120(16):1640\u201345. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192644.","journal-title":"Circulation"},{"issue":"6","key":"8277_CR102","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jbspin.2018.12.005","volume":"86","author":"A Courties","year":"2019","unstructured":"Courties A, Berenbaum F, Sellam J. The phenotypic approach to osteoarthritis: a look at metabolic syndrome-associated osteoarthritis. Joint Bone Spine. 2019, Nov;86(6):725\u201330. https:\/\/doi.org\/10.1016\/j.jbspin.2018.12.005.","journal-title":"Joint Bone Spine"},{"key":"8277_CR103","doi-asserted-by":"publisher","first-page":"865370","DOI":"10.3389\/fbioe.2022.865370","volume":"10","author":"C Zhang","year":"2022","unstructured":"Zhang C, Lin Y, Yan CH, Zhang W. Adipokine signaling pathways in osteoarthritis. Front Bioeng Biotechnol. 2022;10:865370. https:\/\/doi.org\/10.3389\/fbioe.2022.865370.","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"8277_CR104","doi-asserted-by":"publisher","first-page":"19747","DOI":"10.1038\/s41598-025-95344-9","volume":"15","author":"S Zheng","year":"2025","unstructured":"Zheng S, Shao L, Zhu J, Sun J, Chen Z, Cao X, et al. Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data. Sci Rep. 2025, June, 5;15(1):19747. https:\/\/doi.org\/10.1038\/s41598-025-95344-9.","journal-title":"Sci Rep"},{"key":"8277_CR105","doi-asserted-by":"publisher","first-page":"215145932513603","DOI":"10.1177\/21514593251360384","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Gao G, Zhu Z. The correlations of sarcopenia and obesity status with prevalence of osteoarthritis in older adults. Geriatr Orthop Surg Rehabil. 2025;16:21514593251360384. https:\/\/doi.org\/10.1177\/21514593251360384.","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"15","key":"8277_CR106","doi-asserted-by":"publisher","first-page":"7573","DOI":"10.3390\/ijms26157573","volume":"26","author":"A Falvino","year":"2025","unstructured":"Falvino A, Bonanni R, Tarantino U, Tancredi V, Cariati I. Which approach to choose to counteract musculoskeletal aging? A comprehensive review on the multiple effects of exercise. IJMS. 2025, Aug, 5;26(15):7573. https:\/\/doi.org\/10.3390\/ijms26157573.","journal-title":"IJMS"},{"issue":"1","key":"8277_CR107","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s40520-025-03012-9","volume":"37","author":"J Liu","year":"2025","unstructured":"Liu J, Xia X, Wang Z, Wang Y, Qin G. Osteosarcopenia, osteoarthritis and frailty: a two-sample mendelian randomization study. Aging Clin Exp Res. 2025, Apr, 21;37(1):132. https:\/\/doi.org\/10.1007\/s40520-025-03012-9.","journal-title":"Aging Clin Exp Res"},{"key":"8277_CR108","doi-asserted-by":"publisher","first-page":"112788","DOI":"10.1016\/j.exger.2025.112788","volume":"206","author":"Z Liu","year":"2025","unstructured":"Liu Z, Chen X, Ruan Z, Wang C, Yuan D, Xiao W, et al. Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis. Exp Gerontology. 2025, July;206:112788. https:\/\/doi.org\/10.1016\/j.exger.2025.112788.","journal-title":"Exp Gerontology"},{"key":"8277_CR109","doi-asserted-by":"publisher","unstructured":"Zhang C, Xiong B, Shi Y, Tian T, Wang R, Zhang G, et al. Causal association between sarcopenia-related traits and osteoarthritis: a bidirectional 2-sample mendelian randomization study. Med (Baltim). 2025, July, 11;104(28):e43069. https:\/\/doi.org\/10.1097\/MD.0000000000043069.","DOI":"10.1097\/MD.0000000000043069"},{"key":"8277_CR110","doi-asserted-by":"publisher","first-page":"111993","DOI":"10.1016\/j.mad.2024.111993","volume":"222","author":"M Kalykaki","year":"2024","unstructured":"Kalykaki M, Rubio-Tom\u00e1s T, Tavernarakis N. The role of mitochondria in cytokine and chemokine signalling during ageing. Mechanisms Ageing Devel. 2024, Dec;222:111993. https:\/\/doi.org\/10.1016\/j.mad.2024.111993.","journal-title":"Mechanisms Ageing Devel"},{"issue":"1","key":"8277_CR111","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s13018-025-05847-4","volume":"20","author":"Y Khani","year":"2025","unstructured":"Khani Y, Salmani A, Elahi M, Elahi Vahed I, Sadooghi Rad E, Bahrami Samani A, et al. Peri-operative protein or amino acid supplementation for total joint arthroplasty: a systematic review and meta-analysis. J Orthop Surg Res. 2025, May, 2;20(1):439. https:\/\/doi.org\/10.1186\/s13018-025-05847-4.","journal-title":"J Orthop Surg Res"},{"issue":"6","key":"8277_CR112","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1136\/ard-2023-224997","volume":"83","author":"K Moradi","year":"2024","unstructured":"Moradi K, Kwee RM, Mohajer B, Guermazi A, Roemer FW, Ibad HA, et al. Erosive hand osteoarthritis and sarcopenia: data from osteoarthritis initiative cohort. Ann Rheumatic Dis. 2024, May, 15;83(6):799\u2013806. https:\/\/doi.org\/10.1136\/ard-2023-224997.","journal-title":"Ann Rheumatic Dis"},{"issue":"4","key":"8277_CR113","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3390\/jcm13041107","volume":"13","author":"J Rentflejsz","year":"2024","unstructured":"Rentflejsz J, Wojszel ZB. Diabetes mellitus should be considered while analysing sarcopenia-related biomarkers. JCM. 2024, Feb, 15;13(4):1107. https:\/\/doi.org\/10.3390\/jcm13041107.","journal-title":"JCM"},{"issue":"11","key":"8277_CR114","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2174\/0113894501383329250616070727","volume":"26","author":"J Guan","year":"2025","unstructured":"Guan J, Chen C, Wu S, Zhu H. The role of PGE2 in age-related diseases. CDT. 2025, June, 24;26(11):757\u201369. https:\/\/doi.org\/10.2174\/0113894501383329250616070727.","journal-title":"CDT"},{"key":"8277_CR115","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jot.2025.06.013","volume":"53","author":"DK Lee","year":"2025","unstructured":"Lee DK, Kim HS, Ko KR, Yoon JP, Yoo JI. Why muscle strengthening exercises should target the quadriceps and gluteus maximus in patients with knee osteoarthritis?: effects of knee pain on muscle volume and fatty degeneration based on AI-assisted cross-sectional analysis. J Orthopaedic Transl. 2025, July;53:221\u201330. https:\/\/doi.org\/10.1016\/j.jot.2025.06.013.","journal-title":"J Orthopaedic Transl"},{"key":"8277_CR116","doi-asserted-by":"publisher","first-page":"1570131","DOI":"10.3389\/fcell.2025.1570131","volume":"13","author":"Z Xiang","year":"2025","unstructured":"Xiang Z, Mei H, Wang H, Yao X, Rao J, Zhang W, et al. Cuproptosis and its potential role in musculoskeletal disease. Front. Cell Dev. Biol. 2025;13:1570131. https:\/\/doi.org\/10.3389\/fcell.2025.1570131.","journal-title":"Front. Cell Dev. Biol"},{"issue":"11","key":"8277_CR117","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3390\/antiox9111050","volume":"9","author":"HY Luk","year":"2020","unstructured":"Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, et al. Impacts of Green tea on joint and skeletal muscle health: prospects of translational nutrition. Antioxid (Basel). 2020, Oct, 28;9(11):1050. https:\/\/doi.org\/10.3390\/antiox9111050.","journal-title":"Antioxid (Basel)"},{"key":"8277_CR118","doi-asserted-by":"publisher","first-page":"1189731","DOI":"10.3389\/fphys.2023.1189731","volume":"14","author":"TR Lavorgna","year":"2023","unstructured":"Lavorgna TR, Gressett TE, Chastain WH, Bix GJ. Perlecan: a review of its role in neurologic and musculoskeletal disease. Front. Physiol. 2023;14:1189731. https:\/\/doi.org\/10.3389\/fphys.2023.1189731.","journal-title":"Front. Physiol"},{"key":"8277_CR119","doi-asserted-by":"publisher","unstructured":"Yin P, Jiang Y, Fang X, Wang D, Li Y, Chen M, et al. Cell-based therapies for degenerative musculoskeletal diseases. Adv Sci. 2023, July;10(21):e2207050. https:\/\/doi.org\/10.1002\/advs.202207050.","DOI":"10.1002\/advs.202207050"},{"issue":"7","key":"8277_CR120","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2183\/pjab.101.027","volume":"101","author":"H Asahara","year":"2025","unstructured":"Asahara H. Molecular basis of individual locomotor function: integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system. Proc Jpn Acad, Ser B. 2025;101(7):373\u201393. https:\/\/doi.org\/10.2183\/pjab.101.027.","journal-title":"Proc Jpn Acad, Ser B"},{"issue":"11","key":"8277_CR121","doi-asserted-by":"publisher","first-page":"105263","DOI":"10.1016\/j.jamda.2024.105263","volume":"25","author":"T Iidaka","year":"2024","unstructured":"Iidaka T, Horii C, Tanegashima G, Muraki S, Oka H, Kawaguchi H, et al. Ten-year incidence of sarcopenia in a population-based cohort: results from the research on osteoarthritis\/osteoporosis against disability study. J Am Med Dir Assoc. 2024, Nov;25(11):105263. https:\/\/doi.org\/10.1016\/j.jamda.2024.105263.","journal-title":"J Am Med Dir Assoc"},{"issue":"4","key":"8277_CR122","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s10067-020-05419-3","volume":"40","author":"O Wada","year":"2021","unstructured":"Wada O, Yamada M, Kamitani T, Mizuno K, Kurita N. The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study. Clin Rheumatol. 2021, Apr;40(4):1539\u201346. https:\/\/doi.org\/10.1007\/s10067-020-05419-3.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"8277_CR123","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.semarthrit.2016.04.002","volume":"46","author":"N Veronese","year":"2016","unstructured":"Veronese N, Cereda E, Maggi S, Luchini C, Solmi M, Smith T, et al. Osteoarthritis and mortality: a prospective cohort study and systematic review with meta-analysis. Semin Arthritis Rheumatism. 2016, Oct;46(2):160\u201367. https:\/\/doi.org\/10.1016\/j.semarthrit.2016.04.002.","journal-title":"Semin Arthritis Rheumatism"},{"key":"8277_CR124","doi-asserted-by":"publisher","first-page":"102821","DOI":"10.1016\/j.arr.2025.102821","volume":"110","author":"ELP Ramos","year":"2025","unstructured":"Ramos ELP, Sousa Neto IVD, de, Pinto AP, Cintra DE, Ropelle ER, Pauli JR, et al. Mechanisms underlying the interplay between autophagy and the inflammasome in age-related diseases: implications for exercise immunology. Ageing Res Rev. 2025, Aug;110:102821. https:\/\/doi.org\/10.1016\/j.arr.2025.102821.","journal-title":"Ageing Res Rev"},{"key":"8277_CR125","doi-asserted-by":"publisher","unstructured":"D\u2019Souza CA, Zhao FL, Li X, Xu Y, Dunn SE, Zhang L. OGR1\/GPR68 modulates the severity of experimental autoimmune encephalomyelitis and regulates nitric oxide production by macrophages. PLoS One. 2016, Feb, 1;11(2):e0148439. https:\/\/doi.org\/10.1371\/journal.pone.0148439. Platten, M, editor.","DOI":"10.1371\/journal.pone.0148439"},{"key":"8277_CR126","doi-asserted-by":"publisher","unstructured":"Yuan J, Dong X, Gao Y, Nao J. Pleiotropic regulatory mechanisms and targeted therapeutic prospects of galectin-3 in aging-related diseases. Neurotherapeutics. 2025, Sept, 22;22(6):e00744. https:\/\/doi.org\/10.1016\/j.neurot.2025.e00744.","DOI":"10.1016\/j.neurot.2025.e00744"},{"issue":"1","key":"8277_CR127","doi-asserted-by":"publisher","first-page":"34061","DOI":"10.1038\/s41598-025-14465-3","volume":"15","author":"J Shen","year":"2025","unstructured":"Shen J, Zhou J, Xue F, Shen W, Geng L, Zhang H. Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999\u20132018 cohort. Sci Rep. 2025, Sept, 30;15(1):34061. https:\/\/doi.org\/10.1038\/s41598-025-14465-3.","journal-title":"Sci Rep"},{"key":"8277_CR128","doi-asserted-by":"publisher","first-page":"108684","DOI":"10.1016\/j.maturitas.2025.108684","volume":"201","author":"T Wu","year":"2025","unstructured":"Wu T, Xiong Y, Wang L, Zhou E, He M, Ren T, et al. Associations of neutrophil-based inflammatory markers with all-cause and cardiovascular mortality in individuals with osteoarthritis. Maturitas. 2025, Oct;201:108684. https:\/\/doi.org\/10.1016\/j.maturitas.2025.108684.","journal-title":"Maturitas"},{"key":"8277_CR129","doi-asserted-by":"publisher","unstructured":"Li R, Feng C, Lin K, Wang N, Fan X. Association of endothelial activation and stress index with risk of cardiovascular disease and all-cause mortality in patients with osteoarthritis. Arq Bras Cardiol. 2025, June;122(7):e20250012. https:\/\/doi.org\/10.36660\/abc.20250012i.","DOI":"10.36660\/abc.20250012i"},{"key":"8277_CR130","doi-asserted-by":"publisher","first-page":"152804","DOI":"10.1016\/j.semarthrit.2025.152804","volume":"74","author":"AV Perruccio","year":"2025","unstructured":"Perruccio AV, Kral C, Yip C, Eder L, Power JD, Canizares M, et al. The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: a population-based cohort study using the CLSA. Semin Arthritis Rheumatism. 2025, Oct;74:152804. https:\/\/doi.org\/10.1016\/j.semarthrit.2025.152804.","journal-title":"Semin Arthritis Rheumatism"},{"issue":"11","key":"8277_CR131","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41584-018-0073-x","volume":"14","author":"F Berenbaum","year":"2018","unstructured":"Berenbaum F, Wallace IJ, Lieberman DE, Felson DT. Modern-day environmental factors in the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2018, Nov;14(11):674\u201381. https:\/\/doi.org\/10.1038\/s41584-018-0073-x.","journal-title":"Nat Rev Rheumatol"},{"key":"8277_CR132","doi-asserted-by":"publisher","unstructured":"Turner L, Wanasinghe AI, Brunori P, Santosa S. Is adipose tissue inflammation the culprit of obesity-associated comorbidities? Obes Rev. 2025, Nov;26(11):e13956. https:\/\/doi.org\/10.1111\/obr.13956.","DOI":"10.1111\/obr.13956"},{"key":"8277_CR133","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.17179\/excli2025-8703","volume":"24","author":"R Chalotra","year":"2025","unstructured":"Chalotra R, Gupta A, Singh TG, Singh R. Metabolic syndrome: risk factors and molecular drug targets. Excli J. 2025;24:1193\u2013223. https:\/\/doi.org\/10.17179\/excli2025-8703.","journal-title":"Excli J"},{"key":"8277_CR134","doi-asserted-by":"publisher","unstructured":"Hart HF, White DK, Reichert SM, Stefanik JJ. Associations of physical activity, sedentary behaviour, pain, function and quality of life with diabetes and knee osteoarthritis: data from the osteoarthritis initiative. Musculoskeletal Care. 2025, June;23(2):e70128. https:\/\/doi.org\/10.1002\/msc.70128.","DOI":"10.1002\/msc.70128"},{"issue":"Pt C","key":"8277_CR135","doi-asserted-by":"publisher","first-page":"103664","DOI":"10.1016\/j.gerinurse.2025.103664","volume":"66","author":"G Dong","year":"2025","unstructured":"Dong G, Li N, Li J, Tan P, Lu Y, Liang Q, et al. Prevalence and factors affecting sarcopenia in middle-aged and older adults with knee osteoarthritis: a multicenter cross-sectional study from south China. Geriatric Nurs. 2025, Oct, 18;66(Pt C):103664. https:\/\/doi.org\/10.1016\/j.gerinurse.2025.103664.","journal-title":"Geriatric Nurs"},{"key":"8277_CR136","doi-asserted-by":"publisher","first-page":"1642749","DOI":"10.3389\/fnut.2025.1642749","volume":"12","author":"C Du","year":"2025","unstructured":"Du C, Zhou T, Ji X, Tang X, Yang H, Ma Z, et al. Association of life\u2019s essential 8 and genetic predisposition with the risk of osteoarthritis: a prospective cohort study. Front Nutr. 2025;12:1642749. https:\/\/doi.org\/10.3389\/fnut.2025.1642749.","journal-title":"Front Nutr"},{"key":"8277_CR137","doi-asserted-by":"publisher","unstructured":"Wang N, Lu N, Zhang J, Lu C, Sha T, Wang H. Association of a healthy lifestyle with mortality risk among individuals with osteoarthritis: a prospective cohort study of the Uk biobank. BMJ Open. 2025, Aug, 28;15(8):e092558. https:\/\/doi.org\/10.1136\/bmjopen-2024-092558.","DOI":"10.1136\/bmjopen-2024-092558"},{"issue":"10","key":"8277_CR138","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s40265-025-02234-5","volume":"85","author":"C Beaudart","year":"2025","unstructured":"Beaudart C, Brabant C, Alokail M, Reginster JY, Bruy\u00e8re O. Current evidence on celecoxib safety in the management of chronic musculoskeletal conditions: an umbrella review. Drugs. 2025, Oct;85(10):1289\u2013306. https:\/\/doi.org\/10.1007\/s40265-025-02234-5.","journal-title":"Drugs"},{"issue":"8","key":"8277_CR139","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3390\/biology13080565","volume":"13","author":"SR Gheorghe","year":"2024","unstructured":"Gheorghe SR, Cr\u0103ciun AM, Ily\u00e9s T, Tisa IB, Sur L, Lupan I, et al. Converging mechanisms of vascular and cartilaginous calcification. Biol (Basel). 2024, July, 26;13(8):565. https:\/\/doi.org\/10.3390\/biology13080565.","journal-title":"Biol (Basel)"},{"issue":"3","key":"8277_CR140","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/rheumatology\/keae237","volume":"64","author":"Pa de Jong","year":"2025","unstructured":"de Jong Pa, Harlianto NI, Foppen W, Renkli N\u00d6, Spiering W, Weinans H, et al. Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis. Rheumatol (Oxford). 2025, Mar, 1;64(3):1493\u201399. https:\/\/doi.org\/10.1093\/rheumatology\/keae237.","journal-title":"Rheumatol (Oxford)"},{"issue":"18","key":"8277_CR141","doi-asserted-by":"publisher","first-page":"9182","DOI":"10.3390\/ijms26189182","volume":"26","author":"MM Smith","year":"2025","unstructured":"Smith MM, Melrose J. COMP is a biomarker of cartilage destruction, extracellular matrix and vascular remodeling and tissue repair. IJMS. 2025, Sept, 19;26(18):9182. https:\/\/doi.org\/10.3390\/ijms26189182.","journal-title":"IJMS"},{"issue":"6","key":"8277_CR142","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3390\/biom15060856","volume":"15","author":"M Chen","year":"2025","unstructured":"Chen M, Li W, Lei L, Zhang L. Role of SOST in response to mechanical stimulation in bone and extraosseous organs. Biomolecules. 2025, June, 11;15(6):856. https:\/\/doi.org\/10.3390\/biom15060856.","journal-title":"Biomolecules"},{"issue":"8","key":"8277_CR143","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","volume":"24","author":"M Xu","year":"2018","unstructured":"Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018, Aug;24(8):1246\u201356. https:\/\/doi.org\/10.1038\/s41591-018-0092-9.","journal-title":"Nat Med"},{"key":"8277_CR144","unstructured":"Farrington G, Tonge L, Branagan T, Sudirman S, Fang C, Luk L, et al. The roles of EDA2R in ageing and disease. Aging cell. 2025 Nov 4;e70282."},{"issue":"9","key":"8277_CR145","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3899\/jrheum.100985","volume":"38","author":"D Misra","year":"2011","unstructured":"Misra D, Booth SL, Crosier MD, Ordovas JM, Felson DT, Neogi T. Matrix gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis. J Rheumatol. 2011, Sept;38(9):1960\u201365. https:\/\/doi.org\/10.3899\/jrheum.100985.","journal-title":"J Rheumatol"},{"key":"8277_CR146","doi-asserted-by":"publisher","first-page":"1693456","DOI":"10.3389\/fmolb.2025.1693456","volume":"12","author":"Y Liu","year":"2025","unstructured":"Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li YW. Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies. Front Mol Biosci. 2025;12:1693456. https:\/\/doi.org\/10.3389\/fmolb.2025.1693456.","journal-title":"Front Mol Biosci"},{"key":"8277_CR147","doi-asserted-by":"publisher","first-page":"1660319","DOI":"10.3389\/fendo.2025.1660319","volume":"16","author":"Y Zou","year":"2025","unstructured":"Zou Y, Zhang Y, Sun X, Zhao W, Zhang G. Osteoarthritis as a clinical marker of cardiovascular-kidney-metabolic multimorbidity: a population-based cohort study in China. Front. Endocrinol. 2025;16:1660319. https:\/\/doi.org\/10.3389\/fendo.2025.1660319.","journal-title":"Front. Endocrinol"},{"key":"8277_CR148","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.2147\/DMSO.S520465","volume":"18","author":"M Brom","year":"2025","unstructured":"Brom M, Saxer F, Mindeholm L, Schieker M, Conaghan PG. Is it time to revisit the role of interleukin-1 inhibitors in osteoarthritis? DMSO. 2025;18:1753\u201364. https:\/\/doi.org\/10.2147\/DMSO.S520465.","journal-title":"DMSO"},{"issue":"9","key":"8277_CR149","doi-asserted-by":"publisher","first-page":"103864","DOI":"10.1016\/j.autrev.2025.103864","volume":"24","author":"E Bilgin","year":"2025","unstructured":"Bilgin E, Venerito V, Bogdanos DP. Glucagon-like peptide-1 (GLP-1) receptor agonists in rheumatology: a review of current evidence and future directions. Autoimmun Rev. 2025, Aug, 29;24(9):103864. https:\/\/doi.org\/10.1016\/j.autrev.2025.103864.","journal-title":"Autoimmun Rev"},{"issue":"9","key":"8277_CR150","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1111\/ajt.17102","volume":"22","author":"CM Liao","year":"2022","unstructured":"Liao CM, Wulfmeyer VC, Chen R, Erlangga Z, Sinning J, Von M\u00e4ssenhausen A, et al. Induction of ferroptosis selectively eliminates senescent tubular cells. Am J Transpl. 2022, Sept;22(9):2158\u201368. https:\/\/doi.org\/10.1111\/ajt.17102.","journal-title":"Am J Transpl"},{"issue":"9","key":"8277_CR151","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","volume":"10","author":"A Latremoliere","year":"2009","unstructured":"Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Sport Hist Pain. 2009, Sept;10(9):895\u2013926. https:\/\/doi.org\/10.1016\/j.jpain.2009.06.012.","journal-title":"J Sport Hist Pain"},{"issue":"5","key":"8277_CR152","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1365-2982.2010.01491.x","volume":"22","author":"S Bradesi","year":"2010","unstructured":"Bradesi S. Role of spinal cord glia in the central processing of peripheral pain perception. Neurogastroenterology Motil. 2010, May;22(5):499\u2013511. https:\/\/doi.org\/10.1111\/j.1365-2982.2010.01491.x.","journal-title":"Neurogastroenterology Motil"},{"issue":"5","key":"8277_CR153","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1097\/j.pain.0000000000001209","volume":"159","author":"WJ Cottam","year":"2018","unstructured":"Cottam WJ, Iwabuchi SJ, Drabek MM, Reckziegel D, Auer DP. Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. Pain. 2018, May;159(5):929\u201338. https:\/\/doi.org\/10.1097\/j.pain.0000000000001209.","journal-title":"Pain"},{"issue":"10","key":"8277_CR154","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/j.1532-2149.2014.499.x","volume":"18","author":"E Lluch","year":"2014","unstructured":"Lluch E, Torres R, Nijs J, Van Oosterwijck J. Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review. Eur J Pain. 2014, Nov;18(10):1367\u201375. https:\/\/doi.org\/10.1002\/j.1532-2149.2014.499.x.","journal-title":"Eur J Pain"},{"key":"8277_CR155","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2147\/CEOR.S189610","volume":"11","author":"T Tsuji","year":"2019","unstructured":"Tsuji T, Nakata K, Vietri J, Jaffe DH. The added burden of depression in patients with osteoarthritis in Japan. CEOR. 2019, 11: 411\u201321. https:\/\/doi.org\/10.2147\/CEOR.S189610.","journal-title":"CEOR"},{"issue":"13","key":"8277_CR156","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.3390\/ijms20133130","volume":"20","author":"S Yang","year":"2019","unstructured":"Yang S, Chang MC. Chronic pain: structural and functional changes in brain structures and associated negative affective states. IJMS. 2019, June, 26;20(13):3130. https:\/\/doi.org\/10.3390\/ijms20133130.","journal-title":"IJMS"},{"issue":"1","key":"8277_CR157","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri.2015.5","volume":"16","author":"AH Miller","year":"2016","unstructured":"Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016, Jan;16(1):22\u201334. https:\/\/doi.org\/10.1038\/nri.2015.5.","journal-title":"Nat Rev Immunol"},{"key":"8277_CR158","doi-asserted-by":"publisher","first-page":"174480692412750","DOI":"10.1177\/17448069241275097","volume":"20","author":"E Hazrati","year":"2024","unstructured":"Hazrati E, Eftekhar SP, Mosaed R, Shiralizadeh Dini S, Namazi M. Understanding the kynurenine pathway: a narrative review on its impact across chronic pain conditions. Mol Pain. 2024;20:17448069241275097. https:\/\/doi.org\/10.1177\/17448069241275097.","journal-title":"Mol Pain"},{"key":"8277_CR159","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fimmu.2020.00249","volume":"11","author":"L Lanser","year":"2020","unstructured":"Lanser L, Kink P, Egger EM, Willenbacher W, Fuchs D, Weiss G, et al. Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer. Front Immunol. 2020;11:249. https:\/\/doi.org\/10.3389\/fimmu.2020.00249.","journal-title":"Front Immunol"},{"key":"8277_CR160","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/104024","volume":"2013","author":"R Lugo-Huitr\u00f3n","year":"2013","unstructured":"Lugo-Huitr\u00f3n R, Ugalde Mu\u00f1iz P, Pineda B, Pedraza-Chaverr\u00ed J, R\u00edos C, P\u00e9rez-de la Cruz V. Quinolinic acid: an endogenous neurotoxin with multiple targets. Oxidative Med Cellular Longevity. 2013;2013:1\u201314. https:\/\/doi.org\/10.1155\/2013\/104024.","journal-title":"Oxidative Med Cellular Longevity"},{"key":"8277_CR161","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jpsychires.2015.05.007","volume":"68","author":"GZ R\u00e9us","year":"2015","unstructured":"R\u00e9us GZ, Jansen K, Titus S, Carvalho AF, Gabbay V, Quevedo J. Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies. J Psychiatric Res. 2015, Sept;68:316\u201328. https:\/\/doi.org\/10.1016\/j.jpsychires.2015.05.007.","journal-title":"J Psychiatric Res"},{"issue":"12","key":"8277_CR162","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.2522\/ptj.20130597","volume":"94","author":"KE Hannibal","year":"2014","unstructured":"Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014, Dec;94(12):1816\u201325. https:\/\/doi.org\/10.2522\/ptj.20130597.","journal-title":"Phys Ther"},{"issue":"10","key":"8277_CR163","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.psyneuen.2005.04.006","volume":"30","author":"E Fries","year":"2005","unstructured":"Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology. 2005, Nov;30(10):1010\u201316. https:\/\/doi.org\/10.1016\/j.psyneuen.2005.04.006.","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"8277_CR164","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.joca.2016.06.018","volume":"24","author":"LC Carlesso","year":"2016","unstructured":"Carlesso LC, Sturgeon JA, Zautra AJ. Exploring the relationship between disease-related pain and cortisol levels in women with osteoarthritis. Osteoarthr Cartil. 2016, Dec;24(12):2048\u201354. https:\/\/doi.org\/10.1016\/j.joca.2016.06.018.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"8277_CR165","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12882-024-03672-1","volume":"25","author":"K Gao","year":"2024","unstructured":"Gao K, Zhang C, Zhang Y, Zhang L, Xu J, Xue H, et al. Is chronic kidney disease associated with osteoarthritis? The United States national health and nutrition examination survey 2011\u20132020. BMC Nephrol. 2024, July, 25;25(1):236. https:\/\/doi.org\/10.1186\/s12882-024-03672-1.","journal-title":"BMC Nephrol"},{"issue":"1","key":"8277_CR166","doi-asserted-by":"publisher","first-page":"12540","DOI":"10.1038\/s41598-025-97756-z","volume":"15","author":"L Pang","year":"2025","unstructured":"Pang L, Wu K, Zhu Y, Wang Q, Zheng Z, Lv C, et al. Osteoarthritis is a risk factor for renal function injury based on the national health and nutrition examination survey and mendelian randomized study. Sci Rep. 2025, Apr, 12;15(1):12540. https:\/\/doi.org\/10.1038\/s41598-025-97756-z.","journal-title":"Sci Rep"},{"issue":"1","key":"8277_CR167","first-page":"102","volume":"80","author":"S Sharma","year":"2025","unstructured":"Sharma S, Rampal S, Jaiman A, Saravanamuttu SL, Jaiman A, Kamaruzaman L, et al. Exploring musculoskeletal disorders in end-stage kidney disease: a systematic review. Med J Malaysia. 2025, Jan;80(1):102\u201307.","journal-title":"Med J Malaysia"},{"issue":"1","key":"8277_CR168","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/CORR.0000000000003592","volume":"484","author":"CM Chou","year":"2026","unstructured":"Chou CM, Chuang TC, Chiang CH. Factors that increase the risk of prosthetic joint infection within 90 days after THA and TKA: a nationwide population-based study. Clin Orthop Relat Res. 2026, June, 26;484(1):109\u201316. https:\/\/doi.org\/10.1097\/CORR.0000000000003592.","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"8277_CR169","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.3390\/jcm14041187","volume":"14","author":"D Maman","year":"2025","unstructured":"Maman D, Eynhoren G, Ben-Zvi L, Steinfeld Y, Yonai Y, Berkovich Y. Impact of bariatric surgery on postoperative outcomes, complications, and revision rates in total knee arthroplasty: a big data analysis. JCM. 2025, Feb, 11;14(4):1187. https:\/\/doi.org\/10.3390\/jcm14041187.","journal-title":"JCM"},{"issue":"9","key":"8277_CR170","doi-asserted-by":"publisher","first-page":"107526","DOI":"10.1016\/j.cdnut.2025.107526","volume":"9","author":"S Dewar","year":"2025","unstructured":"Dewar S, Janevic MR, Batsis JA, Alexander NB. The optimal health weight and lifestyle (OHWL) clinic: comprehensive, multidisciplinary and geriatric-focused care for multimorbid older adults with obesity. Curr Developments Nutr. 2025, Sept;9(9):107526. https:\/\/doi.org\/10.1016\/j.cdnut.2025.107526.","journal-title":"Curr Developments Nutr"},{"issue":"4","key":"8277_CR171","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3390\/ijms26041567","volume":"26","author":"RS Yang","year":"2025","unstructured":"Yang RS, Chan DC, Chung YP, Liu SH. Chronic kidney disease and osteoarthritis: current understanding and future research directions. IJMS. 2025, Feb, 13;26(4):1567. https:\/\/doi.org\/10.3390\/ijms26041567.","journal-title":"IJMS"},{"issue":"5","key":"8277_CR172","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1002\/ptr.8455","volume":"39","author":"SN Rahaman","year":"2025","unstructured":"Rahaman SN, Lishadevi M, Anandasadagopan SK. Unraveling the molecular mechanisms of osteoarthritis: the potential of polyphenols as therapeutic agents. Phytotherapy Res. 2025, May;39(5):2038\u201371. https:\/\/doi.org\/10.1002\/ptr.8455.","journal-title":"Phytotherapy Res"},{"issue":"1","key":"8277_CR173","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1186\/s12889-023-16490-1","volume":"23","author":"B Al-Omari","year":"2023","unstructured":"Al-Omari B, Farhat J, Khan M, Grancharov H, Zahr ZA, Hanna S, et al. Exploring patient treatment decision making for osteoarthritis in the UAE: a cross-sectional adaptive choice-based conjoint study. BMC Public Health. 2023, Aug, 12;23(1):1542. https:\/\/doi.org\/10.1186\/s12889-023-16490-1.","journal-title":"BMC Public Health"},{"issue":"1","key":"8277_CR174","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12967-024-04941-1","volume":"22","author":"Z Lu","year":"2024","unstructured":"Lu Z, Li X, Qi Y, Li B, Chen L. Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders. J Transl Med. 2024, Feb, 6;22(1):138. https:\/\/doi.org\/10.1186\/s12967-024-04941-1.","journal-title":"J Transl Med"},{"key":"8277_CR175","doi-asserted-by":"publisher","first-page":"109223","DOI":"10.1016\/j.jnutbio.2022.109223","volume":"112","author":"Y Min","year":"2023","unstructured":"Min Y, Ahn D, Truong TMT, Kim M, Heo Y, Jee Y, et al. Excessive sucrose exacerbates high fat diet-induced hepatic inflammation and fibrosis promoting osteoarthritis in mice model. The J Nutritional Biochem. 2023, Feb;112:109223. https:\/\/doi.org\/10.1016\/j.jnutbio.2022.109223.","journal-title":"The J Nutritional Biochem"},{"issue":"5","key":"8277_CR176","doi-asserted-by":"publisher","first-page":"6439","DOI":"10.1007\/s11357-025-01816-1","volume":"47","author":"M Del Rio-Moreno","year":"2025","unstructured":"Del Rio-Moreno M, Poudel SB, Stilgenbauer L, Cordoba-Chacon J, Sadagurski M, Kineman RD, et al. Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis. Geroscience. 2025, July, 26;47(5):6439\u201354. https:\/\/doi.org\/10.1007\/s11357-025-01816-1.","journal-title":"Geroscience"},{"key":"8277_CR177","doi-asserted-by":"publisher","unstructured":"Yu S, Liu Y, Xue B, Zhang X, Gao M, Lu D. The impact of BMI on the causal relationship between NAFLD and OA: a 2-sample mendelian randomization study exploring gene interactions and metabolic pathways. Med (Baltim). 2025, Oct, 10;104(41):e45123. https:\/\/doi.org\/10.1097\/MD.0000000000045123.","DOI":"10.1097\/MD.0000000000045123"},{"key":"8277_CR178","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jor.2025.06.027","volume":"65","author":"C Hand","year":"2025","unstructured":"Hand C, Bohn C, Sasaki J, Angotti M, Eilen H, Forsythe B. Complication profiles after total hip arthroplasty in non-cirrhotic NAFLD versus cirrhotic patients: a national matched cohort comparison. J Educ Chang Orthop. 2025, July;65:346\u201350. https:\/\/doi.org\/10.1016\/j.jor.2025.06.027.","journal-title":"J Educ Chang Orthop"},{"key":"8277_CR179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9091605","volume":"2022","author":"O Rahimi","year":"2022","unstructured":"Rahimi O, Asadi Louie N, Salehi A, Faed Maleki F. Hepatorenal protective effects of hydroalcoholic extract of solidago canadensis L. against paracetamol-induced toxicity in mice. J Toxicol. 2022;2022:1\u201311. https:\/\/doi.org\/10.1155\/2022\/9091605.","journal-title":"J Toxicol"},{"issue":"1","key":"8277_CR180","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41533-018-0101-y","volume":"28","author":"B St\u00e4llberg","year":"2018","unstructured":"St\u00e4llberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, et al. Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients. Npj Prim Care Research Med. 2018, Sept, 10;28(1):33. https:\/\/doi.org\/10.1038\/s41533-018-0101-y.","journal-title":"Npj Prim Care Research Med"},{"issue":"4","key":"8277_CR181","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3390\/healthcare10040736","volume":"10","author":"SK Kim","year":"2022","unstructured":"Kim SK, Kwak SG, Choe JY. Decline of lung function in knee and spine osteoarthritis in the Korean population: cross-sectional analysis of data from the Korea national health and nutrition examination survey. Healthcare (Basel). 2022, Apr, 15;10(4):736. https:\/\/doi.org\/10.3390\/healthcare10040736.","journal-title":"Healthcare (Basel)"},{"issue":"12","key":"8277_CR182","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1093\/rheumatology\/keaa166","volume":"59","author":"MM Ward","year":"2020","unstructured":"Ward MM, A S. Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis. Rheumatology (Oxford, England) [Internet]. Rheumatology. 2020, Jan, 12;59(12). Available from: 3817\u201325. https:\/\/doi.org\/10.1093\/rheumatology\/keaa166. https:\/\/pubmed.ncbi.nlm.nih.gov\/32442295\/. 2025 Nov 7.","journal-title":"Rheumatology"},{"key":"8277_CR183","unstructured":"K E, C D, K E, S S, C M. Pierre-marie bamberger syndrome leading to the diagnosis and surgical treatment of a localized lung cancer. Cureus [Internet]. 2023, Nov, 18;15(11). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/38111395\/. 2025 Nov 7."},{"issue":"6","key":"8277_CR184","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.4103\/jcrt.JCRT_469_19","volume":"17","author":"R Subhashini","year":"2021","unstructured":"Subhashini R, Srinivasamurthy BC, Bhat RV, Kaliaperumal A, Sivagurunathan GM. Metastatic adenocarcinoma presenting as monoarticular arthritis of the knee: a case report with review of literature. J Cancer Res Ther. 2021;17(6):1562\u201364. https:\/\/doi.org\/10.4103\/jcrt.JCRT_469_19.","journal-title":"J Cancer Res Ther"},{"issue":"8","key":"8277_CR185","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.12998\/wjcc.v9.i8.2015","volume":"9","author":"DS Moon","year":"2021","unstructured":"Moon DS, Yoon SH, Lee SI, Park SG, Na YS. Interstitial lung disease induced by the roots of achyranthes japonica nakai: three case reports. WJCC. 2021, Mar, 16;9(8):2015\u201321. https:\/\/doi.org\/10.12998\/wjcc.v9.i8.2015.","journal-title":"WJCC"},{"key":"8277_CR186","doi-asserted-by":"publisher","first-page":"116801","DOI":"10.1016\/j.lfs.2019.116801","volume":"254","author":"H Li","year":"2020","unstructured":"Li H, Xie S, Li H, Zhang R, Zhang H. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K\/akt\/mTOR axis. Life Sci. 2020, Aug, 1;254:116801. https:\/\/doi.org\/10.1016\/j.lfs.2019.116801.","journal-title":"Life Sci"},{"issue":"5","key":"8277_CR187","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00402-020-03485-5","volume":"141","author":"R Dukan","year":"2021","unstructured":"Dukan R, Mal H, Castier Y, Rousseau MA, Boyer P. Safety of shoulder arthroplasty in lung transplant recipients. Arch Orthop Trauma Surg. 2021, May;141(5):795\u2013801. https:\/\/doi.org\/10.1007\/s00402-020-03485-5.","journal-title":"Arch Orthop Trauma Surg"},{"issue":"1","key":"8277_CR188","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13075-019-1915-x","volume":"21","author":"Y Wang","year":"2019","unstructured":"Wang Y, Hussain SM, Wluka AE, Lim YZ, Abram F, Pelletier JP, et al. Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the osteoarthritis initiative\u2014a prospective cohort study. Arthritis Res Ther. 2019, Dec;21(1):127. https:\/\/doi.org\/10.1186\/s13075-019-1915-x.","journal-title":"Arthritis Res Ther"},{"issue":"20","key":"8277_CR189","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1001\/jama.2025.3471","volume":"333","author":"F Pan","year":"2025","unstructured":"Pan F, Wang Y, Lim YZ, Urquhart DM, Estee MM, Wluka AE, et al. Metformin for knee osteoarthritis in patients with overweight or obesity: a randomized clinical trial. JAMA. 2025, May, 27;333(20):1804. https:\/\/doi.org\/10.1001\/jama.2025.3471.","journal-title":"JAMA"},{"issue":"7","key":"8277_CR190","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","volume":"12","author":"RF Loeser","year":"2016","unstructured":"Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016, July;12(7):412\u201320. https:\/\/doi.org\/10.1038\/nrrheum.2016.65.","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"8277_CR191","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1016\/j.joca.2016.07.017","volume":"24","author":"MA Karsdal","year":"2016","unstructured":"Karsdal MA, Michaelis M, Ladel C, Siebuhr AS, Bihlet AR, Andersen JR, et al. Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future. Osteoarthr Cartil. 2016, Dec;24(12):2013\u201321. https:\/\/doi.org\/10.1016\/j.joca.2016.07.017.","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"8277_CR192","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1136\/annrheumdis-2014-205348","volume":"74","author":"X Chevalier","year":"2015","unstructured":"Chevalier X, Ravaud P, Maheu E, Baron G, Rialland A, Vergnaud P, et al. Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial. Ann Rheumatic Dis. 2015, Sept;74(9):1697\u2013705. https:\/\/doi.org\/10.1136\/annrheumdis-2014-205348.","journal-title":"Ann Rheumatic Dis"},{"issue":"7","key":"8277_CR193","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1002\/art.40840","volume":"71","author":"RM Fleischmann","year":"2019","unstructured":"Fleischmann RM, Bliddal H, Blanco FJ, Schnitzer TJ, Peterfy C, Chen S, et al. A phase II trial of Lutikizumab, an anti\u2013Interleukin-1\u03b1\/\u03b2 dual variable Domain immunoglobulin, in knee osteoarthritis patients with synovitis. Arthritis Rheumatol. 2019, July;71(7):1056\u201369. https:\/\/doi.org\/10.1002\/art.40840.","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"8277_CR194","doi-asserted-by":"publisher","first-page":"509","DOI":"10.7326\/M20-0527","volume":"173","author":"M Schieker","year":"2020","unstructured":"Schieker M, Conaghan PG, Mindeholm L, Praestgaard J, Solomon DH, Scotti C, et al. Effects of interleukin-1\u03b2 inhibition on incident hip and knee replacement: exploratory analyses from a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2020, Oct, 6;173(7):509\u201315. https:\/\/doi.org\/10.7326\/M20-0527.","journal-title":"Ann Intern Med"},{"issue":"1","key":"8277_CR195","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3899\/jrheum.2023-0816","volume":"51","author":"P Sengprasert","year":"2024","unstructured":"Sengprasert P, Kamenkit O, Tanavalee A, Reantragoon R. The immunological facets of chondrocytes in osteoarthritis: a narrative review. J Rheumatol. 2024, Nov, 1;jrheum. 51(1):13\u201324. https:\/\/doi.org\/10.3899\/jrheum.2023-0816.","journal-title":"J Rheumatol"},{"issue":"1","key":"8277_CR196","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.joca.2024.10.003","volume":"33","author":"HD Welhaven","year":"2025","unstructured":"Welhaven HD, Welfley AH, June RK. Osteoarthritis year in review 2024: molecular biomarkers of osteoarthritis. Osteoarthr Cartil. 2025, Jan;33(1):67\u201387. https:\/\/doi.org\/10.1016\/j.joca.2024.10.003.","journal-title":"Osteoarthr Cartil"},{"key":"8277_CR197","doi-asserted-by":"publisher","unstructured":"Wangzhou A, Price TJ. Reinvigorating drug development around NGF signaling for pain. J Clin Investigation. 2025, Feb, 17;135(4):e189029. https:\/\/doi.org\/10.1172\/JCI189029.","DOI":"10.1172\/JCI189029"},{"issue":"10","key":"8277_CR198","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.joca.2025.06.004","volume":"33","author":"D Ca\u00f1ada-Garc\u00eda","year":"2025","unstructured":"Ca\u00f1ada-Garc\u00eda D, Calvo-Enrique L, Lisa S, Sousa-Valente J, L\u00f3pez-Garc\u00eda M, Arisi I, et al. Gene expression analyses in mouse sensory ganglia determine a crucial role of NGF\/TrkA in knee osteoarthritis chronification. Osteoarthr Cartil. 2025, Oct;33(10):1180\u201393. https:\/\/doi.org\/10.1016\/j.joca.2025.06.004.","journal-title":"Osteoarthr Cartil"},{"key":"8277_CR199","doi-asserted-by":"publisher","first-page":"1201328","DOI":"10.3389\/fphys.2023.1201328","volume":"14","author":"S Menges","year":"2023","unstructured":"Menges S, Michaelis M, Kleinschmidt-D\u00f6rr K. Anti-NGF treatment worsens subchondral bone and cartilage measures while improving symptoms in floor-housed rabbits with osteoarthritis. Front. Physiol. 2023;14:1201328. https:\/\/doi.org\/10.3389\/fphys.2023.1201328.","journal-title":"Front. Physiol"},{"issue":"16","key":"8277_CR200","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","volume":"363","author":"NE Lane","year":"2010","unstructured":"Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, Smith MD, et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med. 2010, Oct, 14;363(16):1521\u201331. https:\/\/doi.org\/10.1056\/NEJMoa0901510.","journal-title":"N Engl J Med"},{"issue":"6","key":"8277_CR201","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.joca.2011.01.009","volume":"19","author":"TJ Schnitzer","year":"2011","unstructured":"Schnitzer TJ, Lane NE, Birbara C, Smith MD, Simpson SL, Brown MT. Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain. Osteoarthr Cartil. 2011, June;19(6):639\u201346. https:\/\/doi.org\/10.1016\/j.joca.2011.01.009.","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"8277_CR202","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/art.41674","volume":"73","author":"MC Hochberg","year":"2021","unstructured":"Hochberg MC, Carrino JA, Schnitzer TJ, Guermazi A, Walsh DA, White A, et al. Long-term safety and efficacy of subcutaneous tanezumab versus nonsteroidal antiinflammatory drugs for hip or knee osteoarthritis: a randomized trial. Arthritis & Rheumatol. 2021, July;73(7):1167\u201377. https:\/\/doi.org\/10.1002\/art.41674.","journal-title":"Arthritis & Rheumatol"},{"key":"8277_CR203","doi-asserted-by":"publisher","first-page":"1069057","DOI":"10.3389\/fendo.2022.1069057","volume":"13","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, Ren Q, Jiao L, Huang J, Yi J, Chen J, et al. The potential roles of JAK\/STAT signaling in the progression of osteoarthritis. Front. Endocrinol. 2022;13:1069057. https:\/\/doi.org\/10.3389\/fendo.2022.1069057.","journal-title":"Front. Endocrinol"},{"key":"8277_CR204","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jaut.2016.10.008","volume":"77","author":"J Lin","year":"2017","unstructured":"Lin J, He Y, Chen J, Zeng Z, Yang B, Ou Q. A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6. J autoimmunity. 2017, Feb;77:67\u201375. https:\/\/doi.org\/10.1016\/j.jaut.2016.10.008.","journal-title":"J autoimmunity"},{"issue":"12","key":"8277_CR205","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1038\/nm.2543","volume":"17","author":"Q Wang","year":"2011","unstructured":"Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2011, Nov, 6;17(12):1674\u201379. https:\/\/doi.org\/10.1038\/nm.2543.","journal-title":"Nat Med"},{"issue":"2","key":"8277_CR206","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1136\/annrheumdis-2012-201703","volume":"72","author":"AD Cook","year":"2013","unstructured":"Cook AD, Pobjoy J, Sarros S, Steidl S, D\u00fcrr M, Lacey DC, et al. Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheumatic Dis. 2013, Feb;72(2):265\u201370. https:\/\/doi.org\/10.1136\/annrheumdis-2012-201703.","journal-title":"Ann Rheumatic Dis"},{"issue":"11","key":"8277_CR207","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/j.joca.2015.05.016","volume":"23","author":"A Courties","year":"2015","unstructured":"Courties A, Gualillo O, Berenbaum F, Sellam J. Metabolic stress-induced joint inflammation and osteoarthritis. Osteoarthr Cartil. 2015, Nov;23(11):1955\u201365. https:\/\/doi.org\/10.1016\/j.joca.2015.05.016.","journal-title":"Osteoarthr Cartil"},{"key":"8277_CR208","doi-asserted-by":"publisher","first-page":"1003370","DOI":"10.3389\/fphar.2022.1003370","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Deng C, Ma X, Wu Q, Zhou F, Liu X. The association between statin use and osteoarthritis-related outcomes: an updated systematic review and meta-analysis. Front Pharmacol. 2022;13:1003370. https:\/\/doi.org\/10.3389\/fphar.2022.1003370.","journal-title":"Front Pharmacol"},{"issue":"4","key":"8277_CR209","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/antiox14040492","volume":"14","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Zhang Z, Tu C, Chen X, He R. Advanced glycation end products in disease development and potential interventions. Antioxid (Basel). 2025, Apr, 18;14(4):492. https:\/\/doi.org\/10.3390\/antiox14040492.","journal-title":"Antioxid (Basel)"},{"issue":"2","key":"8277_CR210","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/acel.12562","volume":"16","author":"K McCulloch","year":"2017","unstructured":"McCulloch K, Litherland GJ, Rai TS. Cellular senescence in osteoarthritis pathology. Aging Cell. 2017, Apr;16(2):210\u201318. https:\/\/doi.org\/10.1111\/acel.12562.","journal-title":"Aging Cell"},{"issue":"1","key":"8277_CR211","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9 JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol Mech Dis. 2010;5(1):99\u2013118. https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102144.","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"6","key":"8277_CR212","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nm.4324","volume":"23","author":"OH Jeon","year":"2017","unstructured":"Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017, June;23(6):775\u201381. https:\/\/doi.org\/10.1038\/nm.4324.","journal-title":"Nat Med"},{"issue":"6","key":"8277_CR213","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s12272-025-01551-3","volume":"48","author":"Z Jenei-Lanzl","year":"2025","unstructured":"Jenei-Lanzl Z, Maurer S, Brenner RE, Zaucke F, Fuchs M, Riegger J. Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs \u2013 a more refined perspective. Arch. Pharm. Res. 2025, June;48(6):467\u201394. https:\/\/doi.org\/10.1007\/s12272-025-01551-3.","journal-title":"Arch. Pharm. Res"},{"issue":"5","key":"8277_CR214","first-page":"3","volume":"120","author":"GA Hawker","year":"2019","unstructured":"Hawker GA. Osteoarthritis is a serious disease. Clin Exp Rheumatol. 2019, 37 Suppl 120(5):3\u20136.","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"8277_CR215","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","volume":"15","author":"PG Conaghan","year":"2019","unstructured":"Conaghan PG, Cook AD, Hamilton JA, Tak PP. Therapeutic options for targeting inflammatory osteoarthritis pain. Nat Rev Rheumatol. 2019, June;15(6):355\u201363. https:\/\/doi.org\/10.1038\/s41584-019-0221-y.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"8277_CR216","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/acr.23239","volume":"70","author":"AM Rathbun","year":"2018","unstructured":"Rathbun AM, Stuart EA, Shardell M, Yau MS, Baumgarten M, Hochberg MC. Dynamic effects of depressive symptoms on osteoarthritis knee pain. Arthritis Care Res (Hoboken). 2018, Jan;70(1):80\u201388. https:\/\/doi.org\/10.1002\/acr.23239.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"8277_CR217","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12891-016-1286-2","volume":"17","author":"A Dell\u2019isola","year":"2016","unstructured":"Dell\u2019isola A, Allan R, Smith SL, Marreiros SSP, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016, Oct, 12;17(1):425. https:\/\/doi.org\/10.1186\/s12891-016-1286-2.","journal-title":"BMC Musculoskelet Disord"},{"issue":"8","key":"8277_CR218","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.joca.2015.03.036","volume":"23","author":"VB Kraus","year":"2015","unstructured":"Kraus VB, Blanco FJ, Englund M, Karsdal MA, Lohmander LS. Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthr Cartil. 2015, Aug;23(8):1233\u201341. https:\/\/doi.org\/10.1016\/j.joca.2015.03.036.","journal-title":"Osteoarthr Cartil"},{"issue":"12","key":"8277_CR219","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.joca.2009.06.001","volume":"17","author":"MF Sowers","year":"2009","unstructured":"Sowers MF, Karvonen-Gutierrez CA, Yosef M, Jannausch M, Jiang Y, Garnero P, et al. Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women. Osteoarthr Cartil. 2009, Dec;17(12):1609\u201314. https:\/\/doi.org\/10.1016\/j.joca.2009.06.001.","journal-title":"Osteoarthr Cartil"},{"key":"8277_CR220","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.2147\/JIR.S499835","volume":"18","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Zhao Y, Li LF, Fan QQ, Huang BB, Du HZ, et al. Metabolism-related adipokines and metabolic diseases: their role in osteoarthritis. JIR. 2025;18:1207\u201333. https:\/\/doi.org\/10.2147\/JIR.S499835.","journal-title":"JIR"},{"issue":"11","key":"8277_CR221","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.joca.2023.08.005","volume":"31","author":"M Liu","year":"2023","unstructured":"Liu M, Haque N, Huang J, Zhai G. Osteoarthritis year in review 2023: metabolite and protein biomarkers. Osteoarthr Cartil. 2023, Nov;31(11):1437\u201353. https:\/\/doi.org\/10.1016\/j.joca.2023.08.005.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"8277_CR222","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.berh.2014.02.002","volume":"28","author":"FW Roemer","year":"2014","unstructured":"Roemer FW, Eckstein F, Hayashi D, Guermazi A. The role of imaging in osteoarthritis. Best Pract ResearchClin Rheumatol. 2014, Feb;28(1):31\u201360. https:\/\/doi.org\/10.1016\/j.berh.2014.02.002.","journal-title":"Best Pract ResearchClin Rheumatol"},{"issue":"1","key":"8277_CR223","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cpet.2022.09.002","volume":"18","author":"M Jarraya","year":"2023","unstructured":"Jarraya M, Roemer FW, B\u00e4uerle T, Kogan F, Guermazi A. PET imaging in osteoarthritis. PET Clin. 2023, Jan;18(1):21\u201329. https:\/\/doi.org\/10.1016\/j.cpet.2022.09.002.","journal-title":"PET Clin"},{"issue":"3","key":"8277_CR224","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.joca.2017.11.014","volume":"26","author":"AE Nelson","year":"2018","unstructured":"Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthr Cartil. 2018, Mar;26(3):319\u201325. https:\/\/doi.org\/10.1016\/j.joca.2017.11.014.","journal-title":"Osteoarthr Cartil"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08277-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08277-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08277-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:02:55Z","timestamp":1782331375000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08277-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":224,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8277"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08277-w","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"808"}}