{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:14:46Z","timestamp":1790126086985,"version":"4.0.1"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82173452"],"award-info":[{"award-number":["No.82173452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Excellent Young Talent Cultivation Program of the Fujian Medical University Union Hospital","award":["2022XH034"],"award-info":[{"award-number":["2022XH034"]}]},{"name":"High-level Talent Development Program of Fujian Cancer Hospital","award":["2024YNG13"],"award-info":[{"award-number":["2024YNG13"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J011286"],"award-info":[{"award-number":["2023J011286"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Work Program for Young and Middle-aged Talents in Medical and Health Care of Fujian Province to conduct overseas (abroad) study and training","award":["the Work Program for Young and Middle-aged Talents in Medical and Health Care of Fujian Province to conduct overseas (abroad) study and training"],"award-info":[{"award-number":["the Work Program for Young and Middle-aged Talents in Medical and Health Care of Fujian Province to conduct overseas (abroad) study and training"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08309-5","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:27:19Z","timestamp":1779776839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of lactate and lipid metabolism in microglia upon cognitive impairment following radiation-induced brain injury"],"prefix":"10.1186","volume":"24","author":[{"given":"Zeyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2892-9620","authenticated-orcid":false,"given":"Rong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"8309_CR1","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.prro.2024.08.005","volume":"15","author":"O Haisraely","year":"2025","unstructured":"Haisraely O, Mayer A, Jaffe M, Ben-Ayun M, Dubinsky S, Taliansky A, et al. Memory tract sparing using diffusion tensor imaging in radiation planning of primary brain tumors. Pract Radiat Oncol. 2025;15:e3\u20139. https:\/\/doi.org\/10.1016\/j.prro.2024.08.005.","journal-title":"Pract Radiat Oncol"},{"key":"8309_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00073","author":"D Greene-Schloesser","year":"2012","unstructured":"Greene-Schloesser D, Robbins ME, Peiffer AM, Shaw EG, Wheeler KT, Chan MD. Radiation-induced brain injury: a review. Front Oncol [Internet]. 2012. https:\/\/doi.org\/10.3389\/fonc.2012.00073. [cited 2025 Sept 23];2.","journal-title":"Front Oncol [Internet]"},{"key":"8309_CR3","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s11065-021-09522-3","volume":"32","author":"KE Pike","year":"2022","unstructured":"Pike KE, Cavuoto MG, Li L, Wright BJ, Kinsella GJ. Subjective Cognitive Decline: Level of Risk for Future Dementia and Mild Cognitive Impairment, a Meta-Analysis of Longitudinal Studies. Neuropsychol Rev. 2022;32:703\u201335. https:\/\/doi.org\/10.1007\/s11065-021-09522-3.","journal-title":"Neuropsychol Rev"},{"key":"8309_CR4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.14283\/jpad.2021.27","volume":"8","author":"X-T Wang","year":"2021","unstructured":"Wang X-T, Wang Z-T, Hu H-Y, Qu Y, Wang M, Shen X-N, et al. Association of subjective cognitive decline with risk of cognitive impairment and dementia: a systematic review and meta-analysis of prospective longitudinal studies. J Prev Alzheimer\u2019s Dis. 2021;8:277\u201385. https:\/\/doi.org\/10.14283\/jpad.2021.27.","journal-title":"J Prev Alzheimer\u2019s Dis"},{"key":"8309_CR5","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/mrm.27112","volume":"80","author":"J Constanzo","year":"2018","unstructured":"Constanzo J, Dumont M, Lebel R, Tremblay L, Whittingstall K, Masson-C\u00f4t\u00e9 L, et al. Diffusion MRI monitoring of specific structures in the irradiated rat brain. Magn Reson Med. 2018;80:1614\u201325. https:\/\/doi.org\/10.1002\/mrm.27112.","journal-title":"Magn Reson Med"},{"key":"8309_CR6","doi-asserted-by":"publisher","first-page":"9392","DOI":"10.12659\/MSM.917537","volume":"25","author":"C Ma","year":"2019","unstructured":"Ma C, Zhou J, Xu X, Wang L, Qin S, Hu C, et al. The construction of a radiation-induced brain injury model and preliminary study on the effect of human recombinant endostatin in treating radiation-induced brain injury. Med Sci Monit. 2019;25:9392\u2013401. https:\/\/doi.org\/10.12659\/MSM.917537.","journal-title":"Med Sci Monit"},{"key":"8309_CR7","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","volume":"34","author":"R-Y Pan","year":"2022","unstructured":"Pan R-Y, He L, Zhang J, Liu X, Liao Y, Gao J, et al. Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in alzheimer\u2019s disease. Cell Metab. 2022;34:634\u2013e6486. https:\/\/doi.org\/10.1016\/j.cmet.2022.02.013.","journal-title":"Cell Metab"},{"key":"8309_CR8","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1158\/1078-0432.CCR-11-2903","volume":"19","author":"D Greene-Schloesser","year":"2013","unstructured":"Greene-Schloesser D, Moore E, Robbins ME. Molecular pathways: radiation-induced cognitive impairment. Clin Cancer Res. 2013;19:2294\u2013300. https:\/\/doi.org\/10.1158\/1078-0432.CCR-11-2903.","journal-title":"Clin Cancer Res"},{"key":"8309_CR9","doi-asserted-by":"publisher","first-page":"102875","DOI":"10.1016\/j.arr.2025.102875","volume":"112","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Luo B, Sun X, Nagashima H, Wu Y, Liang G, et al. Non-histone lysine lactylation: emerging roles in tumor biology and therapeutic implications. Ageing Res Rev. 2025;112:102875. https:\/\/doi.org\/10.1016\/j.arr.2025.102875.","journal-title":"Ageing Res Rev"},{"key":"8309_CR10","doi-asserted-by":"publisher","first-page":"e70922","DOI":"10.1096\/fj.202501615R","volume":"39","author":"R Chen","year":"2025","unstructured":"Chen R, Xu R, Ma J. The role of lactate in drug addiction. FASEB J. 2025;39:e70922. https:\/\/doi.org\/10.1096\/fj.202501615R.","journal-title":"FASEB J"},{"key":"8309_CR11","doi-asserted-by":"publisher","first-page":"2200102","DOI":"10.1002\/prca.202200102","volume":"17","author":"Y Rong","year":"2023","unstructured":"Rong Y, Dong F, Zhang G, Tang M, Zhao X, Zhang Y, et al. The crosstalking of lactate-histone lactylation and tumor. Proteom Clin Apps. 2023;17:2200102. https:\/\/doi.org\/10.1002\/prca.202200102.","journal-title":"Proteom Clin Apps"},{"key":"8309_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41419-023-06211-2","volume":"14","author":"S Liu","year":"2023","unstructured":"Liu S, Wang W, Hu S, Jia B, Tuo B, Sun H, et al. Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity. Cell Death Dis. 2023;14:679. https:\/\/doi.org\/10.1038\/s41419-023-06211-2.","journal-title":"Cell Death Dis"},{"key":"8309_CR13","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s12974-024-03303-4","volume":"21","author":"Y Wang","year":"2024","unstructured":"Wang Y, Li P, Xu Y, Feng L, Fang Y, Song G, et al. Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms. J Neuroinflammation. 2024;21:308. https:\/\/doi.org\/10.1186\/s12974-024-03303-4.","journal-title":"J Neuroinflammation"},{"key":"8309_CR14","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.3390\/antiox12122087","volume":"12","author":"Q Shang","year":"2023","unstructured":"Shang Q, Bian X, Zhu L, Liu J, Wu M, Lou S. Lactate mediates high-intensity interval training\u2014induced promotion of hippocampal mitochondrial function through the GPR81-ERK1\/2 pathway. Antioxidants. 2023;12:2087. https:\/\/doi.org\/10.3390\/antiox12122087.","journal-title":"Antioxidants"},{"key":"8309_CR15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12974-023-02879-7","volume":"20","author":"L Wei","year":"2023","unstructured":"Wei L, Yang X, Wang J, Wang Z, Wang Q, Ding Y, et al. H3K18 lactylation of senescent microglia potentiates brain aging and alzheimer\u2019s disease through the NF\u03baB signaling pathway. J Neuroinflammation. 2023;20:208. https:\/\/doi.org\/10.1186\/s12974-023-02879-7.","journal-title":"J Neuroinflammation"},{"key":"8309_CR16","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1021\/acschemneuro.6b00120","volume":"7","author":"A Roux","year":"2016","unstructured":"Roux A, Jackson SN, Muller L, Barbacci D, O\u2019Rourke J, Thanos PK, et al. Ethanol induced brain lipid changes in mice assessed by mass spectrometry. ACS Chem Neurosci. 2016;7:1148\u201356. https:\/\/doi.org\/10.1021\/acschemneuro.6b00120.","journal-title":"ACS Chem Neurosci"},{"key":"8309_CR17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","volume":"105","author":"AA Nugent","year":"2020","unstructured":"Nugent AA, Lin K, Van Lengerich B, Lianoglou S, Przybyla L, Davis SS, et al. TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge. Neuron. 2020;105:837\u2013e8549. https:\/\/doi.org\/10.1016\/j.neuron.2019.12.007.","journal-title":"Neuron"},{"key":"8309_CR18","doi-asserted-by":"publisher","first-page":"e20210227","DOI":"10.1084\/jem.20210227","volume":"218","author":"G Gouna","year":"2021","unstructured":"Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, et al. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021;218:e20210227. https:\/\/doi.org\/10.1084\/jem.20210227.","journal-title":"J Exp Med"},{"key":"8309_CR19","doi-asserted-by":"publisher","first-page":"953534","DOI":"10.3389\/fncel.2022.953534","volume":"16","author":"C Li","year":"2022","unstructured":"Li C, Wang Y, Xing Y, Han J, Zhang Y, Zhang A, et al. Regulation of microglia phagocytosis and potential involvement of exercise. Front Cell Neurosci. 2022;16:953534. https:\/\/doi.org\/10.3389\/fncel.2022.953534.","journal-title":"Front Cell Neurosci"},{"key":"8309_CR20","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/jrr\/rraa023","volume":"61","author":"S Pathikonda","year":"2020","unstructured":"Pathikonda S, Cheng SH, Yu KN. Role of PARP1 regulation in radiation-induced rescue effect. J Radiat Res. 2020;61:352\u201367. https:\/\/doi.org\/10.1093\/jrr\/rraa023.","journal-title":"J Radiat Res"},{"key":"8309_CR21","doi-asserted-by":"publisher","first-page":"101117","DOI":"10.1016\/j.plipres.2021.101117","volume":"84","author":"M Sz\u00e1nt\u00f3","year":"2021","unstructured":"Sz\u00e1nt\u00f3 M, Gupte R, Kraus WL, Pacher P, Bai P. PARPs in lipid metabolism and related diseases. Prog Lipid Res. 2021;84:101117. https:\/\/doi.org\/10.1016\/j.plipres.2021.101117.","journal-title":"Prog Lipid Res"},{"key":"8309_CR22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/cells10020198","volume":"10","author":"BA Loving","year":"2021","unstructured":"Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, et al. Lipoprotein lipase regulates microglial lipid droplet accumulation. Cells. 2021;10:198. https:\/\/doi.org\/10.3390\/cells10020198.","journal-title":"Cells"},{"key":"8309_CR23","doi-asserted-by":"publisher","first-page":"101339","DOI":"10.1016\/j.redox.2019.101339","volume":"28","author":"A Young","year":"2020","unstructured":"Young A, Oldford C, Mailloux RJ. Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues. Redox Biol. 2020;28:101339. https:\/\/doi.org\/10.1016\/j.redox.2019.101339.","journal-title":"Redox Biol"},{"key":"8309_CR24","doi-asserted-by":"publisher","first-page":"12494","DOI":"10.3390\/ijms222212494","volume":"22","author":"R Reiter","year":"2021","unstructured":"Reiter R, Sharma R, Rosales-Corral S, Manucha W, Chuffa LGDA, Zuccari DAPDC. Melatonin and pathological cell interactions: mitochondrial glucose processing in cancer cells. Int J Mol Sci. 2021;22:12494. https:\/\/doi.org\/10.3390\/ijms222212494.","journal-title":"Int J Mol Sci"},{"key":"8309_CR25","doi-asserted-by":"publisher","first-page":"12740","DOI":"10.3390\/ijms252312740","volume":"25","author":"AV Panov","year":"2024","unstructured":"Panov AV, Mayorov VI, Dikalov SI. Role of fatty acids \u03b2-oxidation in the metabolic interactions between organs. Int J Mol Sci. 2024;25:12740. https:\/\/doi.org\/10.3390\/ijms252312740.","journal-title":"Int J Mol Sci"},{"key":"8309_CR26","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1186\/s12967-024-05543-7","volume":"22","author":"D Wu","year":"2024","unstructured":"Wu D, Wang S, Wang F, Zhang Q, Zhang Z, Li X. Lactate dehydrogenase a (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension. J Transl Med. 2024;22:738. https:\/\/doi.org\/10.1186\/s12967-024-05543-7.","journal-title":"J Transl Med"},{"key":"8309_CR27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41586-025-09297-0","volume":"645","author":"J Gautam","year":"2025","unstructured":"Gautam J, Wu J, Lally JSV, McNicol JD, Fayyazi R, Ahmadi E, et al. ACLY inhibition promotes tumour immunity and suppresses liver cancer. Nature. 2025;645:507\u201317. https:\/\/doi.org\/10.1038\/s41586-025-09297-0.","journal-title":"Nature"},{"key":"8309_CR28","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/s42255-024-01011-0","volume":"6","author":"X Liu","year":"2024","unstructured":"Liu X, Li S, Cui Q, Guo B, Ding W, Liu J, et al. Activation of GPR81 by lactate drives tumour-induced cachexia. Nat Metab. 2024;6:708\u201323. https:\/\/doi.org\/10.1038\/s42255-024-01011-0.","journal-title":"Nat Metab"},{"key":"8309_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fimmu.2017.00517","volume":"8","author":"K Lumniczky","year":"2017","unstructured":"Lumniczky K, Szatm\u00e1ri T, S\u00e1fr\u00e1ny G. Ionizing radiation-induced immune and inflammatory reactions in the brain. Front Immunol. 2017;8:517. https:\/\/doi.org\/10.3389\/fimmu.2017.00517.","journal-title":"Front Immunol"},{"key":"8309_CR30","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/genes10090640","volume":"10","author":"A Michaelidesov\u00e1","year":"2019","unstructured":"Michaelidesov\u00e1 A, Kon\u00ed\u0159ov\u00e1 J, Bart\u016fn\u011bk P, Z\u00edkov\u00e1 M. Effects of radiation therapy on neural stem cells. Genes. 2019;10:640. https:\/\/doi.org\/10.3390\/genes10090640.","journal-title":"Genes"},{"key":"8309_CR31","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.2174\/1389450111009011413","volume":"11","author":"ME Robbins","year":"2010","unstructured":"Robbins ME, Zhao W, Garcia-Espinosa MA, Diz DI. Renin-angiotensin system blockers and modulation of radiation-induced brain injury. Curr Drug Targets. 2010;11:1413\u201322. https:\/\/doi.org\/10.2174\/1389450111009011413.","journal-title":"Curr Drug Targets"},{"key":"8309_CR32","doi-asserted-by":"publisher","first-page":"27796","DOI":"10.3390\/ijms161126068","volume":"16","author":"S Balentova","year":"2015","unstructured":"Balentova S, Adamkov M. Molecular, cellular and functional effects of radiation-induced brain injury: a review. Int J Mol Sci. 2015;16:27796\u2013815. https:\/\/doi.org\/10.3390\/ijms161126068.","journal-title":"Int J Mol Sci"},{"key":"8309_CR33","doi-asserted-by":"publisher","first-page":"vdaa057","DOI":"10.1093\/noajnl\/vdaa057","volume":"2","author":"C Turnquist","year":"2020","unstructured":"Turnquist C, Harris BT, Harris CC. Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation. Neuro-Oncol Adv. 2020;2:vdaa057. https:\/\/doi.org\/10.1093\/noajnl\/vdaa057.","journal-title":"Neuro-Oncol Adv"},{"key":"8309_CR34","first-page":"3275","volume":"13","author":"C Gan","year":"2023","unstructured":"Gan C, Li W, Xu J, Pang L, Tang L, Yu S, et al. Advances in the study of the molecular biological mechanisms of radiation-induced brain injury. Am J Cancer Res. 2023;13:3275\u201399.","journal-title":"Am J Cancer Res"},{"key":"8309_CR35","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3390\/brainsci14121295","volume":"14","author":"M Li","year":"2024","unstructured":"Li M, Tong F, Wu B, Dong X. Radiation-induced brain injury: mechanistic insights and the promise of gut\u2013brain axis therapies. Brain Sci. 2024;14:1295. https:\/\/doi.org\/10.3390\/brainsci14121295.","journal-title":"Brain Sci"},{"key":"8309_CR36","doi-asserted-by":"publisher","first-page":"1252796","DOI":"10.3389\/fneur.2023.1252796","volume":"14","author":"D Lendvai-Emmert","year":"2023","unstructured":"Lendvai-Emmert D, Magyar-Sumegi ZD, Hegedus E, Szarka N, Fazekas B, Amrein K, et al. Mild traumatic brain injury-induced persistent blood\u2013brain barrier disruption is prevented by cyclosporine a treatment in hypertension. Front Neurol. 2023;14:1252796. https:\/\/doi.org\/10.3389\/fneur.2023.1252796.","journal-title":"Front Neurol"},{"key":"8309_CR37","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1006\/bbrc.2000.2975","volume":"273","author":"Y Kataoka","year":"2000","unstructured":"Kataoka Y, Cui Y, Yamada H, Utsunomiya K, Niiya H, Yanase H, et al. Neovascularization with blood-brain barrier breakdown in delayed neuronal death. Biochem Biophys Res Commun. 2000;273:637\u201341. https:\/\/doi.org\/10.1006\/bbrc.2000.2975.","journal-title":"Biochem Biophys Res Commun"},{"key":"8309_CR38","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.jsxm.2019.08.015","volume":"16","author":"RC Wortel","year":"2019","unstructured":"Wortel RC, Mizrachi A, Li H, Markovsky E, Enyedi B, Jacobi J, et al. Sildenafil protects endothelial cells from radiation-induced oxidative stress. J Sex Med. 2019;16:1721\u201333. https:\/\/doi.org\/10.1016\/j.jsxm.2019.08.015.","journal-title":"J Sex Med"},{"key":"8309_CR39","doi-asserted-by":"publisher","first-page":"e1130","DOI":"10.1038\/cddis.2014.99","volume":"5","author":"NT Martin","year":"2014","unstructured":"Martin NT, Nakamura K, Paila U, Woo J, Brown C, Wright JA, et al. Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks. Cell Death Dis. 2014;5:e1130\u20131130. https:\/\/doi.org\/10.1038\/cddis.2014.99.","journal-title":"Cell Death Dis"},{"key":"8309_CR40","doi-asserted-by":"publisher","first-page":"1062491","DOI":"10.3389\/fcvm.2023.1062491","volume":"10","author":"M Xiang","year":"2023","unstructured":"Xiang M, Wu X, Jing H, Novakovic VA, Shi J. The intersection of obesity and (long) COVID-19: hypoxia, thrombotic inflammation, and vascular endothelial injury. Front Cardiovasc Med. 2023;10:1062491. https:\/\/doi.org\/10.3389\/fcvm.2023.1062491.","journal-title":"Front Cardiovasc Med"},{"key":"8309_CR41","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/s41392-025-02375-9","volume":"10","author":"Y Shang","year":"2025","unstructured":"Shang Y, Hu X, Ren M, Ma L, Zhao X, Gao C, et al. Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs. Signal Transduct Target Ther. 2025;10:286. https:\/\/doi.org\/10.1038\/s41392-025-02375-9.","journal-title":"Signal Transduct Target Ther"},{"key":"8309_CR42","doi-asserted-by":"publisher","first-page":"8286","DOI":"10.3390\/ijms23158286","volume":"23","author":"Q Liu","year":"2022","unstructured":"Liu Q, Huang Y, Duan M, Yang Q, Ren B, Tang F. Microglia as therapeutic target for radiation-induced brain injury. Int J Mol Sci. 2022;23:8286. https:\/\/doi.org\/10.3390\/ijms23158286.","journal-title":"Int J Mol Sci"},{"key":"8309_CR43","doi-asserted-by":"publisher","first-page":"e14794","DOI":"10.1111\/cns.14794","volume":"30","author":"Y Wang","year":"2024","unstructured":"Wang Y, Tian J, Liu D, Li T, Mao Y, Zhu C. Microglia in radiation-induced brain injury: Cellular and molecular mechanisms and therapeutic potential. CNS Neurosci Ther. 2024;30:e14794. https:\/\/doi.org\/10.1111\/cns.14794.","journal-title":"CNS Neurosci Ther"},{"key":"8309_CR44","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2174\/1570159X18666200620230321","volume":"18","author":"Y Huang","year":"2020","unstructured":"Huang Y, Chen S, Luo Y, Han Z. Crosstalk between inflammation and the BBB in stroke. Curr Neuropharmacol. 2020;18:1227\u201336. https:\/\/doi.org\/10.2174\/1570159X18666200620230321.","journal-title":"Curr Neuropharmacol"},{"key":"8309_CR45","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/glia.23961","volume":"69","author":"AD Umpierre","year":"2021","unstructured":"Umpierre AD, Wu L. How microglia sense and regulate neuronal activity. Glia. 2021;69:1637\u201353. https:\/\/doi.org\/10.1002\/glia.23961.","journal-title":"Glia"},{"key":"8309_CR46","doi-asserted-by":"publisher","first-page":"101340","DOI":"10.1016\/j.bbrep.2022.101340","volume":"32","author":"T Du","year":"2022","unstructured":"Du T, Zhou X, Zhang RDY, Du X-F. Roles of Ca2\u2009+\u2009activity in injury-induced migration of microglia in zebrafish in vivo. Biochem Biophys Rep. 2022;32:101340. https:\/\/doi.org\/10.1016\/j.bbrep.2022.101340.","journal-title":"Biochem Biophys Rep"},{"key":"8309_CR47","doi-asserted-by":"publisher","first-page":"10045","DOI":"10.3390\/ijms221810045","volume":"22","author":"PT Do","year":"2021","unstructured":"Do PT, Wu C-C, Chiang Y-H, Hu C-J, Chen K-Y. Mesenchymal stem\/stromal cell therapy in blood\u2013brain barrier preservation following ischemia: molecular mechanisms and prospects. Int J Mol Sci. 2021;22:10045. https:\/\/doi.org\/10.3390\/ijms221810045.","journal-title":"Int J Mol Sci"},{"key":"8309_CR48","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12974-020-01790-9","volume":"17","author":"BD Allen","year":"2020","unstructured":"Allen BD, Syage AR, Maroso M, Baddour AAD, Luong V, Minasyan H, et al. Mitigation of helium irradiation-induced brain injury by microglia depletion. J Neuroinflammation. 2020;17:159. https:\/\/doi.org\/10.1186\/s12974-020-01790-9.","journal-title":"J Neuroinflammation"},{"key":"8309_CR49","doi-asserted-by":"publisher","first-page":"4845","DOI":"10.1038\/s41467-018-07295-7","volume":"9","author":"H Lund","year":"2018","unstructured":"Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, et al. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nat Commun. 2018;9:4845. https:\/\/doi.org\/10.1038\/s41467-018-07295-7.","journal-title":"Nat Commun"},{"key":"8309_CR50","doi-asserted-by":"publisher","first-page":"iv37","DOI":"10.1093\/neuonc\/nos196","volume":"14","author":"D Greene-Schloesser","year":"2012","unstructured":"Greene-Schloesser D, Robbins ME. Radiation-induced cognitive impairment-from bench to bedside. Neuro-oncol. 2012;14:iv37\u201344. https:\/\/doi.org\/10.1093\/neuonc\/nos196.","journal-title":"Neuro-oncol"},{"key":"8309_CR51","doi-asserted-by":"publisher","unstructured":"Huang Q, Wang Y, Chen S, Liang F. Glycometabolic reprogramming of microglia in neurodegenerative diseases: insights from neuroinflammation. Aging Dis. 2023;0. https:\/\/doi.org\/10.14336\/AD.2023.0807.","DOI":"10.14336\/AD.2023.0807"},{"key":"8309_CR52","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12974-024-03296-0","volume":"21","author":"M Sadeghdoust","year":"2024","unstructured":"Sadeghdoust M, Das A, Kaushik DK. Fueling neurodegeneration: metabolic insights into microglia functions. J Neuroinflammation. 2024;21:300. https:\/\/doi.org\/10.1186\/s12974-024-03296-0.","journal-title":"J Neuroinflammation"},{"key":"8309_CR53","doi-asserted-by":"publisher","first-page":"100629","DOI":"10.1016\/j.jlr.2024.100629","volume":"65","author":"Z Lan","year":"2024","unstructured":"Lan Z, Lv S, Ge Z, Zhao B, Li L, Li C. Lactic acid regulates lipid droplet aggregation through a microglia-neuron axis in neuroinflammation. J Lipid Res. 2024;65:100629. https:\/\/doi.org\/10.1016\/j.jlr.2024.100629.","journal-title":"J Lipid Res"},{"key":"8309_CR54","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12975-022-01069-6","volume":"14","author":"JP Bielanin","year":"2023","unstructured":"Bielanin JP, Sun D. Significance of microglial energy metabolism in maintaining brain homeostasis. Transl Stroke Res. 2023;14:435\u20137. https:\/\/doi.org\/10.1007\/s12975-022-01069-6.","journal-title":"Transl Stroke Res"},{"key":"8309_CR55","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1007\/s10571-023-01376-y","volume":"43","author":"J Miao","year":"2023","unstructured":"Miao J, Chen L, Pan X, Li L, Zhao B, Lan J. Microglial metabolic reprogramming: emerging insights and therapeutic strategies in neurodegenerative diseases. Cell Mol Neurobiol. 2023;43:3191\u2013210. https:\/\/doi.org\/10.1007\/s10571-023-01376-y.","journal-title":"Cell Mol Neurobiol"},{"key":"8309_CR56","doi-asserted-by":"publisher","first-page":"RP87674","DOI":"10.7554\/eLife.87674","volume":"12","author":"S Watanuki","year":"2024","unstructured":"Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, et al. Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. eLife. 2024;12:RP87674. https:\/\/doi.org\/10.7554\/eLife.87674.","journal-title":"eLife"},{"key":"8309_CR57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1369\/00221554211054585","volume":"70","author":"CJF Van Noorden","year":"2022","unstructured":"Van Noorden CJF, Breznik B, Novak M, Van Dijck AJ, Tanan S, Vittori M, et al. Cell biology meets cell metabolism: energy production is similar in stem cells and in cancer stem cells in brain and bone marrow. J Histochem Cytochem. 2022;70:29\u201351. https:\/\/doi.org\/10.1369\/00221554211054585.","journal-title":"J Histochem Cytochem"},{"key":"8309_CR58","doi-asserted-by":"publisher","unstructured":"Gao R, Gao Y, Su W, Wang R. Decoding microglial polarization and metabolic reprogramming in neurodegenerative diseases: implications for disease progression and therapy. Aging Dis. 2025;0. https:\/\/doi.org\/10.14336\/AD.2024.1629.","DOI":"10.14336\/AD.2024.1629"},{"key":"8309_CR59","doi-asserted-by":"publisher","first-page":"4501","DOI":"10.3390\/molecules28114501","volume":"28","author":"X Liu","year":"2023","unstructured":"Liu X, Jiang N, Zhou W. Various energetic metabolism of microglia in response to different stimulations. Molecules. 2023;28:4501. https:\/\/doi.org\/10.3390\/molecules28114501.","journal-title":"Molecules"},{"key":"8309_CR60","doi-asserted-by":"publisher","first-page":"e209378","DOI":"10.1212\/WNL.0000000000209378","volume":"102","author":"E Benarroch","year":"2024","unstructured":"Benarroch E. What is the role of lactate in brain metabolism, plasticity, and neurodegeneration? Neurology. 2024;102:e209378. https:\/\/doi.org\/10.1212\/WNL.0000000000209378.","journal-title":"Neurology"},{"key":"8309_CR61","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrn.2018.19","volume":"19","author":"PJ Magistretti","year":"2018","unstructured":"Magistretti PJ, Allaman I. Lactate in the brain: from metabolic end-product to signalling molecule. Nat Rev Neurosci. 2018;19:235\u201349. https:\/\/doi.org\/10.1038\/nrn.2018.19.","journal-title":"Nat Rev Neurosci"},{"key":"8309_CR62","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fnins.2020.00460","volume":"14","author":"S Mason","year":"2020","unstructured":"Mason S. A novel, multi-faceted perception of lactate in neurology. Front Neurosci. 2020;14:460. https:\/\/doi.org\/10.3389\/fnins.2020.00460.","journal-title":"Front Neurosci"},{"key":"8309_CR63","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1007\/s11064-024-04135-7","volume":"49","author":"ID Tassinari","year":"2024","unstructured":"Tassinari ID, Rodrigues FDS, Bertram C, Mendes-da-Cruz DA, Guedes RP, Paz AH, et al. Lactate protects microglia and neurons from oxygen\u2013glucose deprivation\/reoxygenation. Neurochem Res. 2024;49:1762\u201381. https:\/\/doi.org\/10.1007\/s11064-024-04135-7.","journal-title":"Neurochem Res"},{"key":"8309_CR64","doi-asserted-by":"publisher","first-page":"587913","DOI":"10.3389\/fimmu.2020.587913","volume":"11","author":"K Yang","year":"2020","unstructured":"Yang K, Xu J, Fan M, Tu F, Wang X, Ha T, et al. Lactate suppresses macrophage pro-inflammatory response to LPS stimulation by inhibition of YAP and NF-\u03baB activation via GPR81-mediated signaling. Front Immunol. 2020;11:587913. https:\/\/doi.org\/10.3389\/fimmu.2020.587913.","journal-title":"Front Immunol"},{"key":"8309_CR65","doi-asserted-by":"publisher","first-page":"e76451","DOI":"10.7554\/eLife.76451","volume":"11","author":"L Kennedy","year":"2022","unstructured":"Kennedy L, Glesaaen ER, Palibrk V, Pannone M, Wang W, Al-Jabri A, et al. Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia. Elife. 2022;11:e76451. https:\/\/doi.org\/10.7554\/eLife.76451.","journal-title":"Elife"},{"key":"8309_CR66","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12017-022-08710-5","volume":"24","author":"R Nicola","year":"2022","unstructured":"Nicola R, Madar R, Okun E. HCAR1-Mediated l-Lactate Signaling Suppresses Microglial Phagocytosis. NeuroMol Med. 2022;24:399\u2013404. https:\/\/doi.org\/10.1007\/s12017-022-08710-5.","journal-title":"NeuroMol Med"},{"key":"8309_CR67","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/NRR.NRR-D-23-00805","volume":"20","author":"H Yang","year":"2025","unstructured":"Yang H, Mo N, Tong L, Dong J, Fan Z, Jia M, et al. Microglia lactylation in relation to central nervous system diseases. Neural Regener Res. 2025;20:29\u201340. https:\/\/doi.org\/10.4103\/NRR.NRR-D-23-00805.","journal-title":"Neural Regener Res"},{"key":"8309_CR68","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-022-00541-z","volume":"17","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Xu H. Microglial lactate metabolism as a potential therapeutic target for alzheimer\u2019s disease. Mol Neurodegeneration. 2022;17:36. https:\/\/doi.org\/10.1186\/s13024-022-00541-z.","journal-title":"Mol Neurodegeneration"},{"key":"8309_CR69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41531-024-00858-0","volume":"11","author":"Q Qin","year":"2025","unstructured":"Qin Q, Wang D, Qu Y, Li J, An K, Mao Z, et al. Enhanced glycolysis-derived lactate promotes microglial activation in parkinson\u2019s disease via histone lactylation. npj Parkinson\u2019s Dis. 2025;11:3. https:\/\/doi.org\/10.1038\/s41531-024-00858-0.","journal-title":"npj Parkinson\u2019s Dis"},{"key":"8309_CR70","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12979-023-00390-4","volume":"20","author":"H Han","year":"2023","unstructured":"Han H, Zhao Y, Du J, Wang S, Yang X, Li W, et al. Exercise improves cognitive dysfunction and neuroinflammation in mice through histone H3 lactylation in microglia. Immun Ageing. 2023;20:63. https:\/\/doi.org\/10.1186\/s12979-023-00390-4.","journal-title":"Immun Ageing"},{"key":"8309_CR71","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12974-024-03186-5","volume":"21","author":"X Hu","year":"2024","unstructured":"Hu X, Huang J, Li Z, Li J, Ouyang F, Chen Z, et al. Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury. J Neuroinflammation. 2024;21:193. https:\/\/doi.org\/10.1186\/s12974-024-03186-5.","journal-title":"J Neuroinflammation"},{"key":"8309_CR72","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3390\/brainsci15030294","volume":"15","author":"Y Chen","year":"2025","unstructured":"Chen Y, Xiao D, Li X. Lactylation and central nervous system diseases. Brain Sci. 2025;15:294. https:\/\/doi.org\/10.3390\/brainsci15030294.","journal-title":"Brain Sci"},{"key":"8309_CR73","doi-asserted-by":"publisher","unstructured":"He Y, Peng Y, Chang Y, Zhu J, Li Z, Huang K, et al. Utilizing the faxitron MultiRad 225 X-ray irradiation system for the construction of mouse chronic whole brain radiation model. J Radiat Res. 2021;rrab086. https:\/\/doi.org\/10.1093\/jrr\/rrab086.","DOI":"10.1093\/jrr\/rrab086"},{"key":"8309_CR74","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3340\/jkns.2023.0049","volume":"66","author":"G G\u00fcrkan","year":"2023","unstructured":"G\u00fcrkan G, Atasoy \u00d6, \u00c7ini N, Sever \u0130H, \u00d6zkul B, Yaprak G, et al. Reparative, Neuroprotective and Anti-neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model. J Korean Neurosurg Soc. 2023;66:511\u201324. https:\/\/doi.org\/10.3340\/jkns.2023.0049.","journal-title":"J Korean Neurosurg Soc"},{"key":"8309_CR75","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","volume":"23","author":"J Marschallinger","year":"2020","unstructured":"Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, et al. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat Neurosci. 2020;23:194\u2013208. https:\/\/doi.org\/10.1038\/s41593-019-0566-1.","journal-title":"Nat Neurosci"},{"key":"8309_CR76","doi-asserted-by":"publisher","first-page":"e16259","DOI":"10.1111\/jnc.16259","volume":"169","author":"ME Traetta","year":"2025","unstructured":"Traetta ME, Vecchiarelli HA, Tremblay M. Fundamental neurochemistry review: lipids across microglial states. J Neurochem. 2025;169:e16259. https:\/\/doi.org\/10.1111\/jnc.16259.","journal-title":"J Neurochem"},{"key":"8309_CR77","doi-asserted-by":"publisher","first-page":"105290","DOI":"10.1016\/j.nbd.2021.105290","volume":"152","author":"S Yang","year":"2021","unstructured":"Yang S, Qin C, Hu Z-W, Zhou L-Q, Yu H-H, Chen M, et al. Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system. Neurobiol Dis. 2021;152:105290. https:\/\/doi.org\/10.1016\/j.nbd.2021.105290.","journal-title":"Neurobiol Dis"},{"key":"8309_CR78","doi-asserted-by":"publisher","first-page":"e00038","DOI":"10.1097\/IN9.0000000000000038","volume":"6","author":"V Kruglov","year":"2024","unstructured":"Kruglov V, Jang IH, Camell CD. Inflammaging and fatty acid oxidation in monocytes and macrophages. Immunometabolism. 2024;6:e00038. https:\/\/doi.org\/10.1097\/IN9.0000000000000038.","journal-title":"Immunometabolism"},{"key":"8309_CR79","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12974-024-03296-0","volume":"21","author":"M Sadeghdoust","year":"2024","unstructured":"Sadeghdoust M, Das A, Kaushik DK. Fueling neurodegeneration: metabolic insights into microglia functions. J Neuroinflammation. 2024;21:300. https:\/\/doi.org\/10.1186\/s12974-024-03296-0.","journal-title":"J Neuroinflammation"},{"key":"8309_CR80","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11033-025-10381-x","volume":"52","author":"R Verma","year":"2025","unstructured":"Verma R, Sharma P, Sharma V, Singh TG. Modulating lipid droplet dynamics in neurodegeneration: an emerging area of molecular pharmacology. Mol Biol Rep. 2025;52:277. https:\/\/doi.org\/10.1007\/s11033-025-10381-x.","journal-title":"Mol Biol Rep"},{"key":"8309_CR81","doi-asserted-by":"publisher","first-page":"e70139","DOI":"10.1002\/mco2.70139","volume":"6","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Zhang S, Zhao X, Wu P, Ying Y, Wu L, et al. ATP11B modulates microglial lipid metabolism and alleviates alzheimer\u2019s disease pathology. Medcomm. 2025;6:e70139. https:\/\/doi.org\/10.1002\/mco2.70139.","journal-title":"Medcomm"},{"key":"8309_CR82","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3390\/antiox9080743","volume":"9","author":"DSA Simpson","year":"2020","unstructured":"Simpson DSA, Oliver PL. ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants. 2020;9:743. https:\/\/doi.org\/10.3390\/antiox9080743.","journal-title":"Antioxidants"},{"key":"8309_CR83","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13578-022-00828-0","volume":"12","author":"D Yang","year":"2022","unstructured":"Yang D, Wang X, Zhang L, Fang Y, Zheng Q, Liu X, et al. Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases. Cell Biosci. 2022;12:106. https:\/\/doi.org\/10.1186\/s13578-022-00828-0.","journal-title":"Cell Biosci"},{"key":"8309_CR84","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s43587-021-00130-7","volume":"1","author":"G Wang","year":"2021","unstructured":"Wang G, Yin W, Shin H, Tian Q, Lu W, Hou SX. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nat Aging. 2021;1:1024\u201337. https:\/\/doi.org\/10.1038\/s43587-021-00130-7.","journal-title":"Nat Aging"},{"key":"8309_CR85","doi-asserted-by":"publisher","first-page":"e02225","DOI":"10.1128\/spectrum.02225-22","volume":"10","author":"W Wang","year":"2022","unstructured":"Wang W, Zhao Y, Bai N, Zhang K-Q, Yang J. G <>Ianiri editor 2022 AMPK is involved in regulating the utilization of carbon sources, conidiation, pathogenicity, and stress response of the nematode-trapping fungus arthrobotrys oligospora. Microbiol Spectr 10 e02225\u201322 https:\/\/doi.org\/10.1128\/spectrum.02225-22.","journal-title":"Microbiol Spectr"},{"key":"8309_CR86","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/jimmun\/vkae034","volume":"214","author":"P Joly","year":"2025","unstructured":"Joly P, Labsy R, Silvin A. Aging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity. J Immunol. 2025;214:880\u20138. https:\/\/doi.org\/10.1093\/jimmun\/vkae034.","journal-title":"J Immunol"},{"key":"8309_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/234975","volume":"2010","author":"S Ramanan","year":"2010","unstructured":"Ramanan S, Zhao W, Riddle DR, Robbins ME. Role of PPARs in radiation-induced brain injury. PPAR Res. 2010;2010:1\u201312. https:\/\/doi.org\/10.1155\/2010\/234975.","journal-title":"PPAR Res"},{"key":"8309_CR88","doi-asserted-by":"publisher","unstructured":"Kennedy L, Morland C, Narum M, Bergersen LH, Rinholm JE. Lactate receptor HCAR1 affects axonal development and contributes to lactate\u2019s protection of axons and myelin in experimental neonatal hypoglycemia. Eneuro. 2025;12. https:\/\/doi.org\/10.1523\/ENEURO.0563-24.2025. ENEURO.563-24.2025.","DOI":"10.1523\/ENEURO.0563-24.2025"},{"key":"8309_CR89","doi-asserted-by":"publisher","first-page":"C1502","DOI":"10.1152\/ajpcell.00346.2023","volume":"325","author":"MA Mohammad Nezhady","year":"2023","unstructured":"Mohammad Nezhady MA, Modaresinejad M, Zia A, Chemtob S. Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological processes. Am J Physiology-Cell Physiol. 2023;325:C1502\u201315. https:\/\/doi.org\/10.1152\/ajpcell.00346.2023.","journal-title":"Am J Physiology-Cell Physiol"},{"key":"8309_CR90","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.4103\/1673-5374.367842","volume":"18","author":"L Leng","year":"2023","unstructured":"Leng L, Zhang J. Microglial metabolic reconfiguration provides a new strategy for the treatment of alzheimer\u2019s disease. Neural Regener Res. 2023;18:1946\u20137. https:\/\/doi.org\/10.4103\/1673-5374.367842.","journal-title":"Neural Regener Res"},{"key":"8309_CR91","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13024-025-00825-0","volume":"20","author":"ES Jung","year":"2025","unstructured":"Jung ES, Choi H, Mook-Jung I. Decoding microglial immunometabolism: a new frontier in alzheimer\u2019s disease research. Mol Neurodegener. 2025;20:37. https:\/\/doi.org\/10.1186\/s13024-025-00825-0.","journal-title":"Mol Neurodegener"},{"key":"8309_CR92","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40035-023-00382-w","volume":"12","author":"I Lepiarz-Raba","year":"2023","unstructured":"Lepiarz-Raba I, Gbadamosi I, Florea R, Paolicelli RC, Jawaid A. Metabolic regulation of microglial phagocytosis: implications for alzheimer\u2019s disease therapeutics. Transl Neurodegener. 2023;12:48. https:\/\/doi.org\/10.1186\/s40035-023-00382-w.","journal-title":"Transl Neurodegener"},{"key":"8309_CR93","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1002\/glia.23271","volume":"66","author":"S Ghosh","year":"2018","unstructured":"Ghosh S, Castillo E, Frias ES, Swanson RA. Bioenergetic regulation of microglia. Glia. 2018;66:1200\u201312. https:\/\/doi.org\/10.1002\/glia.23271.","journal-title":"Glia"},{"key":"8309_CR94","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3389\/fimmu.2020.00493","volume":"11","author":"C Lauro","year":"2020","unstructured":"Lauro C, Limatola C. Metabolic reprograming of microglia in the regulation of the innate inflammatory response. Front Immunol. 2020;11:493. https:\/\/doi.org\/10.3389\/fimmu.2020.00493.","journal-title":"Front Immunol"},{"key":"8309_CR95","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1186\/s12964-024-01748-x","volume":"22","author":"X Jiang","year":"2024","unstructured":"Jiang X, Gao J, Fei X, Geng Y, Yue X, Shi Z, et al. Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema. Cell Commun Signal. 2024;22:374. https:\/\/doi.org\/10.1186\/s12964-024-01748-x.","journal-title":"Cell Commun Signal"},{"key":"8309_CR96","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.2174\/1570159X19666211202123322","volume":"20","author":"MA Haidar","year":"2022","unstructured":"Haidar MA, Ibeh S, Shakkour Z, Reslan MA, Nwaiwu J, Moqidem YA, et al. Crosstalk between microglia and neurons in neurotrauma: an overview of the underlying mechanisms. Curr Neuropharmacol. 2022;20:2050\u201365. https:\/\/doi.org\/10.2174\/1570159X19666211202123322.","journal-title":"Curr Neuropharmacol"},{"key":"8309_CR97","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1667\/RR14616.1","volume":"187","author":"RN Andrews","year":"2017","unstructured":"Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, et al. Cerebrovascular remodeling and neuroinflammation is a late effect of radiation-induced brain injury in non-human primates. Radiat Res. 2017;187:599\u2013611. https:\/\/doi.org\/10.1667\/RR14616.1.","journal-title":"Radiat Res"},{"key":"8309_CR98","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.2147\/DDDT.S367229","volume":"16","author":"A Alhowail","year":"2022","unstructured":"Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI. Protective effects of pioglitazone on cognitive impairment and the underlying mechanisms: a review of literature. Drug Des Dev Ther. 2022;16:2919\u201331. https:\/\/doi.org\/10.2147\/DDDT.S367229.","journal-title":"Drug Des Dev Ther"},{"key":"8309_CR99","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fncel.2019.00212","volume":"13","author":"CN Barber","year":"2019","unstructured":"Barber CN, Raben DM. Lipid metabolism crosstalk in the brain: glia and neurons. Front Cell Neurosci. 2019;13:212. https:\/\/doi.org\/10.3389\/fncel.2019.00212.","journal-title":"Front Cell Neurosci"},{"key":"8309_CR100","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.2147\/CMAR.S441360","volume":"16","author":"P Shamsesfandabadi","year":"2024","unstructured":"Shamsesfandabadi P, Patel A, Liang Y, Shepard M, Wegner R. Radiation-induced cognitive decline: challenges and solutions. Cancer Manag Res. 2024;16:1043\u201352. https:\/\/doi.org\/10.2147\/CMAR.S441360.","journal-title":"Cancer Manag Res"},{"key":"8309_CR101","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/neurosci5040034","volume":"5","author":"L Gonz\u00e1lez-Johnson","year":"2024","unstructured":"Gonz\u00e1lez-Johnson L, Fari\u00f1a A, Far\u00edas G, Zomosa G, Pinilla-Gonz\u00e1lez V, Rojas-Sol\u00e9 C. Exploring neuroprotection against radiation-induced brain injury: a review of key compounds. Neurosci. 2024;5:462\u201384. https:\/\/doi.org\/10.3390\/neurosci5040034.","journal-title":"Neurosci"},{"key":"8309_CR102","doi-asserted-by":"publisher","unstructured":"Jiao H, Natoli R, Valter K, Provis JM, Rutar M. Spatiotemporal cadence of macrophage polarisation in a model of light-induced retinal degeneration. Lewin AS, editor. PLoS ONE. 2015;10:e0143952. https:\/\/doi.org\/10.1371\/journal.pone.0143952","DOI":"10.1371\/journal.pone.0143952"},{"key":"8309_CR103","doi-asserted-by":"publisher","unstructured":"Huang Q, Wang Y, Chen S, Liang F. Glycometabolic reprogramming of microglia in neurodegenerative diseases: insights from neuroinflammation. Aging Dis. 2023;0. https:\/\/doi.org\/10.14336\/AD.2023.0807.","DOI":"10.14336\/AD.2023.0807"},{"key":"8309_CR104","doi-asserted-by":"publisher","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","volume":"15","author":"L Muzio","year":"2021","unstructured":"Muzio L, Viotti A, Martino G. Microglia in neuroinflammation and neurodegeneration: from understanding to therapy. Front Neurosci. 2021;15:742065. https:\/\/doi.org\/10.3389\/fnins.2021.742065.","journal-title":"Front Neurosci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08309-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08309-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08309-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:01:16Z","timestamp":1784851276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08309-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":104,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8309"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08309-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"11 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval and consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"950"}}