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Mechanisms of Action: It plays multi-faceted intervention roles in protein aggregation, neuroinflammation, mitochondrial dysfunction, and tumor progression by targeting key factors such as \u03b1-synuclein, NLRP3 inflammasome, EGFR\/PI3K\/AKT\/mTOR pathway, and mitochondrial-related proteins (e.g. VDAC1). Role in Disease: It has significant pathophysiological implications in diseases such as Parkinson\u2019s disease, Alzheimer\u2019s disease, ischemic stroke, cerebral hemorrhage, and glioblastoma. Translational Potential: Changes in miR-7 expression in bodily fluids (blood, cerebrospinal fluid) and extracellular vesicles demonstrate diagnostic and prognostic potential; delivery systems based on nanomedicine (e.g. liposomes, graphene oxide, AAV vectors) and their combination therapy strategies (e.g. in conjunction with chemotherapy and immunotherapy) enhance its brain targeting and therapeutic efficiency.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n miR-7 is a key regulatory molecule in brain diseases, with significant value for basic research and clinical translation. Future advancements should leverage cutting-edge technologies such as single-cell sequencing, spatial transcriptomics, and intelligent responsive nanocarriers to deepen the understanding of its regulatory networks and address challenges such as mechanism complexity, delivery system targeting, and the lack of clinical translation standards, to accelerate its transition from basic research to clinical application.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12967-026-08313-9","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:44:10Z","timestamp":1779893050000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MicroRNA-7: a versatile player and core target in brain disorders"],"prefix":"10.1186","volume":"24","author":[{"given":"Jianhua","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daosheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"issue":"1","key":"8313_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13578-020-00436-w","volume":"10","author":"J Zhao","year":"2020","unstructured":"Zhao J, Zhou Y, Guo M, Yue D, Chen C, Liang G, et al. 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