{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:49:41Z","timestamp":1793774981847,"version":"4.6.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470951"],"award-info":[{"award-number":["82470951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071080"],"award-info":[{"award-number":["82071080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08330-8","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:14:52Z","timestamp":1780074892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PIEZO1 mediates orthodontic tension force-induced alveolar bone remodeling via the Ca\u00b2\u207a\/YAP-TAZ pathway in periodontal ligament stem cells"],"prefix":"10.1186","volume":"24","author":[{"given":"Tianyi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-8974","authenticated-orcid":false,"given":"Fulan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"8330_CR1","doi-asserted-by":"publisher","first-page":"117464","DOI":"10.1016\/j.bone.2025.117464","volume":"195","author":"X Men","year":"2025","unstructured":"Men X, Chiou WC, Li X, Li Q, Chen X, Zhang K, et al. Klotho senses mechanical stimuli and modulates tension-induced osteogenesis. Bone. 2025;195:117464. https:\/\/doi.org\/10.1016\/j.bone.2025.117464.","journal-title":"Bone"},{"issue":"15","key":"8330_CR2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/scd.2019.0025","volume":"28","author":"O Trubiani","year":"2019","unstructured":"Trubiani O, Pizzicannella J, Caputi S, Marchisio M, Mazzon E, Paganelli R, et al. Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives. Stem Cells Dev. 2019;28(15):995\u20131003. https:\/\/doi.org\/10.1089\/scd.2019.0025.","journal-title":"Stem Cells Dev"},{"key":"8330_CR3","doi-asserted-by":"publisher","first-page":"105657","DOI":"10.1016\/j.jdent.2025.105657","volume":"156","author":"CM Sacramento","year":"2025","unstructured":"Sacramento CM, Casati MZ, Casarin RCV, Sallum EA, Silv\u00e9rio KG. Gastrointestinal cholecystokinin signaling pathway drugs modulate osteogenic\/cementogenic differentiation of human periodontal ligament stem cells. J Dent. 2025;156:105657. https:\/\/doi.org\/10.1016\/j.jdent.2025.105657.","journal-title":"J Dent"},{"issue":"1","key":"8330_CR4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/s13287-024-04058-8","volume":"15","author":"Q Ying","year":"2024","unstructured":"Ying Q, Jiang Y, Sun C, Zhang Y, Gao R, Liu H, et al. AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B\/Wnt self-reinforcing loop. Stem Cell Res Ther. 2024;15(1):431. https:\/\/doi.org\/10.1186\/s13287-024-04058-8.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"8330_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41368-021-00125-5","volume":"13","author":"Y Li","year":"2021","unstructured":"Li Y, Zhan Q, Bao M, Yi J, Li Y. Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade. Int J Oral Sci. 2021;13(1):20. https:\/\/doi.org\/10.1038\/s41368-021-00125-5.","journal-title":"Int J Oral Sci"},{"issue":"1","key":"8330_CR6","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1186\/s13287-025-04777-6","volume":"16","author":"Z Zhao","year":"2025","unstructured":"Zhao Z, Chen L, Zhu S, Yu H, Chen Y, Song J, et al. Periodontal ligament stem cells in tissue remodeling: from mechanical forces to inflammatory signals. Stem Cell Res Ther. 2025;16(1):653. https:\/\/doi.org\/10.1186\/s13287-025-04777-6.","journal-title":"Stem Cell Res Ther"},{"issue":"7526","key":"8330_CR7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature13701","volume":"515","author":"J Li","year":"2014","unstructured":"Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, et al. Piezo1 integration of vascular architecture with physiological force. Nature. 2014;515(7526):279\u201382. https:\/\/doi.org\/10.1038\/nature13701.","journal-title":"Nature"},{"issue":"7835","key":"8330_CR8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","volume":"587","author":"JM Kefauver","year":"2020","unstructured":"Kefauver JM, Ward AB, Patapoutian A. Discoveries in structure and physiology of mechanically activated ion channels. Nature. 2020;587(7835):567\u201376. https:\/\/doi.org\/10.1038\/s41586-020-2933-1.","journal-title":"Nature"},{"issue":"11","key":"8330_CR9","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","volume":"25","author":"B Xiao","year":"2024","unstructured":"Xiao B. Mechanisms of mechanotransduction and physiological roles of PIEZO channels. Nat Rev Mol Cell Biol. 2024;25(11):886\u2013903. https:\/\/doi.org\/10.1038\/s41580-024-00773-5.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"8330_CR10","doi-asserted-by":"publisher","first-page":"e47454","DOI":"10.7554\/eLife.47454","volume":"8","author":"W Sun","year":"2019","unstructured":"Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, et al. The mechanosensitive Piezo1 channel is required for bone formation. eLife. 2019;8:e47454. https:\/\/doi.org\/10.7554\/eLife.47454.","journal-title":"eLife"},{"issue":"1","key":"8330_CR11","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","volume":"11","author":"L Wang","year":"2020","unstructured":"Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W. Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nat Commun. 2020;11(1):282. https:\/\/doi.org\/10.1038\/s41467-019-14146-6.","journal-title":"Nat Commun"},{"issue":"10","key":"8330_CR12","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.7150\/thno.96959","volume":"14","author":"L Lei","year":"2024","unstructured":"Lei L, Wen Z, Cao M, Zhang H, Ling SK, Fu BS, et al. The emerging role of Piezo1 in the musculoskeletal system and disease. Theranostics. 2024;14(10):3963\u201383. https:\/\/doi.org\/10.7150\/thno.96959.","journal-title":"Theranostics"},{"issue":"1","key":"8330_CR13","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1186\/s12903-025-06427-y","volume":"25","author":"Y Du","year":"2025","unstructured":"Du Y, Zheng J, Xu B, Peng C, Yang K. Piezo1 participates in the tension-driven osteogenic differentiation of periodontal ligament stem cells. BMC Oral Health. 2025;25(1):1155. https:\/\/doi.org\/10.1186\/s12903-025-06427-y.","journal-title":"BMC Oral Health"},{"issue":"13","key":"8330_CR14","doi-asserted-by":"publisher","first-page":"e2312081","DOI":"10.1002\/adma.202312081","volume":"36","author":"H Guan","year":"2024","unstructured":"Guan H, Wang W, Jiang Z, Zhang B, Ye Z, Zheng J, et al. Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair. Adv Mater. 2024;36(13):e2312081. https:\/\/doi.org\/10.1002\/adma.202312081.","journal-title":"Adv Mater"},{"key":"8330_CR15","doi-asserted-by":"publisher","unstructured":"Xue F, Zhao Z, Gu Y, Han J, Ye K, Zhang Y. 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis. eLife. 2021;10. https:\/\/doi.org\/10.7554\/eLife.64872.","DOI":"10.7554\/eLife.64872"},{"issue":"10","key":"8330_CR16","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.7150\/ijbs.71390","volume":"18","author":"Y Liu","year":"2022","unstructured":"Liu Y, Tian H, Hu Y, Cao Y, Song H, Lan S, et al. Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing. Int J Biol Sci. 2022;18(10):3961\u201380. https:\/\/doi.org\/10.7150\/ijbs.71390.","journal-title":"Int J Biol Sci"},{"issue":"9429","key":"8330_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","volume":"364","author":"BM Seo","year":"2004","unstructured":"Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364(9429):149\u201355. https:\/\/doi.org\/10.1016\/S0140-6736(04)16627-0.","journal-title":"Lancet"},{"issue":"1","key":"8330_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s11658-023-00453-w","volume":"28","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Cui S, Fu Y, Wang J, Liu J, Wei F. Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells. Cell Mol Biol Lett. 2023;28(1):57. https:\/\/doi.org\/10.1186\/s11658-023-00453-w.","journal-title":"Cell Mol Biol Lett"},{"issue":"2","key":"8330_CR19","doi-asserted-by":"publisher","first-page":"e70039","DOI":"10.1111\/jpi.70039","volume":"77","author":"X Xu","year":"2025","unstructured":"Xu X, Zhang Z, Tian W, Cao M, Wang Z, Li F, et al. Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways. J Pineal Res. 2025;77(2):e70039. https:\/\/doi.org\/10.1111\/jpi.70039.","journal-title":"J Pineal Res"},{"key":"8330_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.actbio.2021.12.035","volume":"141","author":"F Lei","year":"2022","unstructured":"Lei F, Li M, Lin T, Zhou H, Wang F, Su X. Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes. Acta Biomater. 2022;141:333\u201343. https:\/\/doi.org\/10.1016\/j.actbio.2021.12.035.","journal-title":"Acta Biomater"},{"key":"8330_CR21","doi-asserted-by":"publisher","first-page":"105700","DOI":"10.1016\/j.jdent.2025.105700","volume":"156","author":"Z Zhao","year":"2025","unstructured":"Zhao Z, Qiao Q, Sun Y, Wang J, Li X, Zhang L, et al. Human periodontal ligament stem cells and metformin to enhance periodontal regeneration in rats. J Dent. 2025;156:105700. https:\/\/doi.org\/10.1016\/j.jdent.2025.105700.","journal-title":"J Dent"},{"key":"8330_CR22","doi-asserted-by":"publisher","first-page":"117132","DOI":"10.1016\/j.bone.2024.117132","volume":"185","author":"J Liu","year":"2024","unstructured":"Liu J, Wang J, Wang Z, Ren H, Zhang Z, Fu Y, et al. PGC-1\u03b1\/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment. Bone. 2024;185:117132. https:\/\/doi.org\/10.1016\/j.bone.2024.117132.","journal-title":"Bone"},{"key":"8330_CR23","doi-asserted-by":"publisher","unstructured":"Carrisoza-Gaytan R, Mutchler SM, Carattino F, Soong J, Dalghi MG, Wu P, et al. PIEZO1 is a distal nephron mechanosensor and is required for flow-induced K+ secretion. J Clin Invest. 2024;134(5). https:\/\/doi.org\/10.1172\/JCI174806.","DOI":"10.1172\/JCI174806"},{"issue":"1","key":"8330_CR24","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1038\/s41467-022-31103-y","volume":"13","author":"Y Ye","year":"2022","unstructured":"Ye Y, Barghouth M, Dou H, Luan C, Wang Y, Karagiannopoulos A, et al. A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic \u03b2-cells. Nat Commun. 2022;13(1):4237. https:\/\/doi.org\/10.1038\/s41467-022-31103-y.","journal-title":"Nat Commun"},{"key":"8330_CR25","doi-asserted-by":"publisher","unstructured":"Jeon HH, Huang X, Rojas Cortez L, Sripinun P, Lee JM, Hong JJ et al. Inflammation and mechanical force-induced bone remodeling. Periodontology 2000. 2024. https:\/\/doi.org\/10.1111\/prd.12619","DOI":"10.1111\/prd.12619"},{"issue":"1","key":"8330_CR26","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1021\/acsbiomaterials.2c00717","volume":"9","author":"J Xu","year":"2023","unstructured":"Xu J, Lin Y, Tian M, Li X, Yin Y, Li Q, et al. Periodontal Ligament Stem Cell-Derived Extracellular Vesicles Enhance Tension-Induced Osteogenesis. ACS Biomater Sci Eng. 2023;9(1):388\u201398. https:\/\/doi.org\/10.1021\/acsbiomaterials.2c00717.","journal-title":"ACS Biomater Sci Eng"},{"issue":"2","key":"8330_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1093\/ejo\/cjr127","volume":"35","author":"TJ Franzen","year":"2013","unstructured":"Franzen TJ, Brudvik P, Vandevska-Radunovic V. Periodontal tissue reaction during orthodontic relapse in rat molars. Eur J Orthod. 2013;35(2):152\u20139. https:\/\/doi.org\/10.1093\/ejo\/cjr127.","journal-title":"Eur J Orthod"},{"issue":"4","key":"8330_CR28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/ocr.12050","volume":"17","author":"TJ Franzen","year":"2014","unstructured":"Franzen TJ, Monjo M, Rubert M, Vandevska-Radunovic V. Expression of bone markers and micro-CT analysis of alveolar bone during orthodontic relapse. Orthod Craniofac Res. 2014;17(4):249\u201358. https:\/\/doi.org\/10.1111\/ocr.12050.","journal-title":"Orthod Craniofac Res"},{"issue":"1","key":"8330_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s11658-023-00420-5","volume":"28","author":"J Wang","year":"2023","unstructured":"Wang J, Yang H, Ma X, Liu J, Li L, Chen L, et al. LRP6\/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells. Cell Mol Biol Lett. 2023;28(1):7. https:\/\/doi.org\/10.1186\/s11658-023-00420-5.","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"8330_CR30","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s13287-022-03055-z","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang L, Liang H, Sun B, Mi J, Tong X, Wang Y, et al. Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress. Stem Cell Res Ther. 2022;13(1):401. https:\/\/doi.org\/10.1186\/s13287-022-03055-z.","journal-title":"Stem Cell Res Ther"},{"issue":"27","key":"8330_CR31","doi-asserted-by":"publisher","first-page":"e2300713","DOI":"10.1002\/adhm.202300713","volume":"12","author":"ZM Zhang","year":"2023","unstructured":"Zhang ZM, Yu P, Zhou K, Yu FY, Bao RY, Yang MB, et al. Hierarchically Porous Implants Orchestrating a Physiological Viscoelastic and Piezoelectric Microenvironment for Bone Regeneration. Adv Healthc Mater. 2023;12(27):e2300713. https:\/\/doi.org\/10.1002\/adhm.202300713.","journal-title":"Adv Healthc Mater"},{"issue":"32","key":"8330_CR32","doi-asserted-by":"publisher","first-page":"e2504128","DOI":"10.1002\/adma.202504128","volume":"37","author":"C Xu","year":"2025","unstructured":"Xu C, Long Y, Feng L, Liu L, Xu R, Hu W, et al. Bionic Triboelectric Nanogenerator Activates the mechano-electro-biochemical Cascade Effect In Situ to Accelerate Critical-Sized Bone Defect Repair. Adv Mater. 2025;37(32):e2504128. https:\/\/doi.org\/10.1002\/adma.202504128.","journal-title":"Adv Mater"},{"issue":"46","key":"8330_CR33","doi-asserted-by":"publisher","first-page":"e2400502","DOI":"10.1002\/advs.202400502","volume":"11","author":"S Jia","year":"2024","unstructured":"Jia S, Liu W, Zhang M, Wang L, Ren C, Feng C, et al. Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence. Adv Sci (Weinh). 2024;11(46):e2400502. https:\/\/doi.org\/10.1002\/advs.202400502.","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"8330_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejwf.2018.08.001","volume":"7","author":"M Alikhani","year":"2018","unstructured":"Alikhani M, Sangsuwon C, Alansari S, Nervina JM, Teixeira CC. Biphasic theory: breakthrough understanding of tooth movement. J World Fed Orthod. 2018;7(3):82\u20138. https:\/\/doi.org\/10.1016\/j.ejwf.2018.08.001.","journal-title":"J World Fed Orthod"},{"issue":"4","key":"8330_CR35","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ejwf.2023.05.001","volume":"12","author":"JC Maltha","year":"2023","unstructured":"Maltha JC, Kuijpers-Jagtman AM. Mechanobiology of orthodontic tooth movement: An update. J World Fed Orthod. 2023;12(4):156\u2013. https:\/\/doi.org\/10.1016\/j.ejwf.2023.05.001. 60.","journal-title":"J World Fed Orthod"},{"key":"8330_CR36","doi-asserted-by":"publisher","first-page":"152286","DOI":"10.1016\/j.aanat.2024.152286","volume":"255","author":"P Ubuzima","year":"2024","unstructured":"Ubuzima P, Nshimiyimana E, Mukeshimana C, Mazimpaka P, Mugabo E, Mbyayingabo D, et al. Exploring biological mechanisms in orthodontic tooth movement: Bridging the gap between basic research experiments and clinical applications - A comprehensive review. Ann Anat. 2024;255:152286. https:\/\/doi.org\/10.1016\/j.aanat.2024.152286.","journal-title":"Ann Anat"},{"key":"8330_CR37","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-bioeng-070909-105302","volume":"12","author":"CR Jacobs","year":"2010","unstructured":"Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010;12:369\u2013400. https:\/\/doi.org\/10.1146\/annurev-bioeng-070909-105302.","journal-title":"Annu Rev Biomed Eng"},{"issue":"1","key":"8330_CR38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41413-021-00168-8","volume":"9","author":"L Qin","year":"2021","unstructured":"Qin L, He T, Chen S, Yang D, Yi W, Cao H, et al. Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues. Bone Res. 2021;9(1):44. https:\/\/doi.org\/10.1038\/s41413-021-00168-8.","journal-title":"Bone Res"},{"key":"8330_CR39","doi-asserted-by":"publisher","first-page":"110846","DOI":"10.1016\/j.cellsig.2023.110846","volume":"110","author":"S Sayedyahossein","year":"2023","unstructured":"Sayedyahossein S, Thines L, Sacks DB. Ca\u00b2\u207asignaling and the Hippo pathway: Intersections in cellular regulation. Cell Signal. 2023;110:110846. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110846.","journal-title":"Cell Signal"},{"issue":"23","key":"8330_CR40","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.3390\/cells11233724","volume":"11","author":"M Zhai","year":"2022","unstructured":"Zhai M, Cui S, Li L, Cheng C, Zhang Z, Liu J, et al. Mechanical Force Modulates Alveolar Bone Marrow Mesenchymal Cells Characteristics for Bone Remodeling during Orthodontic Tooth Movement through Lactate Production. Cells. 2022;11(23):3724. https:\/\/doi.org\/10.3390\/cells11233724.","journal-title":"Cells"},{"issue":"7350","key":"8330_CR41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","volume":"474","author":"S Dupont","year":"2011","unstructured":"Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, et al. Role of YAP\/TAZ in mechanotransduction. Nature. 2011;474(7350):179\u201383. https:\/\/doi.org\/10.1038\/nature10137.","journal-title":"Nature"},{"issue":"8","key":"8330_CR42","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"B Zhao","year":"2011","unstructured":"Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011;13(8):877\u201383. https:\/\/doi.org\/10.1038\/ncb2303.","journal-title":"Nat Cell Biol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08330-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08330-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08330-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:03:23Z","timestamp":1785798203000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08330-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8330"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08330-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"31 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval for human tissues was obtained from the Research Ethics Committee of Shandong University (no. 20211214, approval date December 30, 2021), and the study was conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from the donors and their parents prior to the surgical procedure. The animal experiments were approved by the Committee on the Ethics of Animal Experiments of Shandong University (no. 20211213; approval date: December 30, 2021). The experiments were conducted in accordance with the guidelines of the Institutional Animal Care and Use Committee (IACUC) and complied with the ARRIVE guidelines for reporting animal research.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors of this review give their consent for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"984"}}