{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:39:03Z","timestamp":1789331943759,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Joint Funds for the innovation of Science and Technology, Fujian province","award":["2024Y9100"],"award-info":[{"award-number":["2024Y9100"]}]},{"name":"Joint Funds for the innovation of Science and Technology, Fujian province","award":["2024Y9294"],"award-info":[{"award-number":["2024Y9294"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01075"],"award-info":[{"award-number":["2023J01075"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08358-w","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:15:44Z","timestamp":1780535744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated isothermal shift assay and multi-omics identify melittin as a novel EGFR-targeting peptide to suppress NSCLC"],"prefix":"10.1186","volume":"24","author":[{"given":"Chenhui","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jietao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-1858","authenticated-orcid":false,"given":"Hong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"8358_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13045-025-01679-1","volume":"18","author":"P-L Su","year":"2025","unstructured":"Su P-L, Furuya N, Asrar A, Rolfo C, Li Z, Carbone DP, et al. Recent advances in therapeutic strategies for non-small cell lung cancer. J Hematol OncolJ Hematol Oncol. 2025;18:35.","journal-title":"J Hematol OncolJ Hematol Oncol"},{"key":"8358_CR2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/cncr.35094","volume":"130","author":"F Griesinger","year":"2024","unstructured":"Griesinger F, Ramagopalan S, Cheung WY, Wilke T, Mueller S, Gupta A, et al. Association between treatment and improvements in overall survival of patients with advanced\/metastatic non\u2013small cell lung cancer since 2011: A study in the United States, Canada, and Germany using retrospective real-world databases. Cancer. 2024;130:530\u201340.","journal-title":"Cancer"},{"key":"8358_CR3","doi-asserted-by":"publisher","first-page":"8661","DOI":"10.3390\/ijms22168661","volume":"22","author":"R Nooreldeen","year":"2021","unstructured":"Nooreldeen R, Bach H. Current and Future Development in Lung Cancer Diagnosis. Int J Mol Sci. 2021;22:8661.","journal-title":"Int J Mol Sci"},{"key":"8358_CR4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/imr.13274","volume":"321","author":"S Li","year":"2024","unstructured":"Li S, Wang A, Wu Y, He S, Shuai W, Zhao M, et al. Targeted therapy for non-small\u2010cell lung cancer: New insights into regulated cell death combined with immunotherapy. Immunol Rev. 2024;321:300\u201334.","journal-title":"Immunol Rev"},{"key":"8358_CR5","doi-asserted-by":"publisher","first-page":"971477","DOI":"10.3389\/fcell.2022.971477","volume":"10","author":"L Li","year":"2022","unstructured":"Li L, Editorial. Drug resistance in lung cancer chemotherapy and personalized chemotherapy. Front Cell Dev Biol. 2022;10:971477.","journal-title":"Front Cell Dev Biol"},{"key":"8358_CR6","doi-asserted-by":"publisher","first-page":"107522","DOI":"10.1016\/j.pharmthera.2020.107522","volume":"210","author":"CB Meador","year":"2020","unstructured":"Meador CB, Hata AN. Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights. Pharmacol Ther. 2020;210:107522.","journal-title":"Pharmacol Ther"},{"key":"8358_CR7","doi-asserted-by":"publisher","first-page":"102520","DOI":"10.1016\/j.ctrv.2023.102520","volume":"114","author":"Y Yu","year":"2023","unstructured":"Yu Y, Yang Y, Li H, Fan Y. Targeting HER2 alterations in non-small cell lung cancer: Therapeutic breakthrough and challenges. Cancer Treat Rev. 2023;114:102520.","journal-title":"Cancer Treat Rev"},{"key":"8358_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3390\/biom10020247","volume":"10","author":"M Ceremuga","year":"2020","unstructured":"Ceremuga M, Stela M, Janik E, Gorniak L, Synowiec E, Sliwinski T, et al. Melittin\u2014A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells. Biomolecules. 2020;10:247.","journal-title":"Biomolecules"},{"key":"8358_CR9","doi-asserted-by":"publisher","first-page":"1001553","DOI":"10.3389\/fphar.2022.1001553","volume":"13","author":"P Shi","year":"2022","unstructured":"Shi P, Xie S, Yang J, Zhang Y, Han S, Su S, et al. Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective. Front Pharmacol. 2022;13:1001553.","journal-title":"Front Pharmacol"},{"key":"8358_CR10","doi-asserted-by":"publisher","first-page":"8738","DOI":"10.1007\/s12035-025-04808-6","volume":"62","author":"P Kadyan","year":"2025","unstructured":"Kadyan P, Singh L. Deciphering the Neuroprotective Action of Bee Venom Peptide Melittin: Insights into Mechanistic Interplay. Mol Neurobiol. 2025;62:8738\u201351.","journal-title":"Mol Neurobiol"},{"key":"8358_CR11","doi-asserted-by":"publisher","first-page":"107430","DOI":"10.1016\/j.phrs.2024.107430","volume":"209","author":"LF Laurindo","year":"2024","unstructured":"Laurindo LF, De Lima EP, Laurindo LF, Rodrigues VD, Chagas EFB, De Alvares Goulart R, et al. The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review. Pharmacol Res. 2024;209:107430.","journal-title":"Pharmacol Res"},{"key":"8358_CR12","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673355946250403071132","author":"H Sun","year":"2025","unstructured":"Sun H, Ding J, Jiang Y, Zhang D, Yu J, Sun S, et al. Melittin Inhibits Ovarian Cancer Cell Growth by Downregulating MMP9 Expression via the JAK2-STAT3 Signaling Pathway. Curr Med Chem [Internet]. 2025. https:\/\/doi.org\/10.2174\/0109298673355946250403071132. [cited 2025 July 4];32.","journal-title":"Curr Med Chem [Internet]"},{"key":"8358_CR13","doi-asserted-by":"publisher","first-page":"177084","DOI":"10.1016\/j.ejphar.2024.177084","volume":"986","author":"Y Wang","year":"2025","unstructured":"Wang Y, Yuan J, Liu J, Li X, Zhou C, Qian M, et al. Melittin suppresses aerobic glycolysis by regulating HSF1\/PDK3 to increase chemosensitivity of NSCLC. Eur J Pharmacol. 2025;986:177084.","journal-title":"Eur J Pharmacol"},{"key":"8358_CR14","doi-asserted-by":"publisher","first-page":"156367","DOI":"10.1016\/j.phymed.2025.156367","volume":"137","author":"R Wu","year":"2025","unstructured":"Wu R, Li N, Huang W, Yang Y, Zang R, Song H, et al. Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism. Phytomedicine. 2025;137:156367.","journal-title":"Phytomedicine"},{"key":"8358_CR15","doi-asserted-by":"publisher","first-page":"11686","DOI":"10.3390\/ijms252111686","volume":"25","author":"K Wang","year":"2024","unstructured":"Wang K, Tao L, Zhu M, Yu X, Lu Y, Yuan B, et al. Melittin Inhibits Colorectal Cancer Growth and Metastasis by Ac-Tivating the Mitochondrial Apoptotic Pathway and Suppressing Epithelial\u2013Mesenchymal Transition and Angiogenesis. Int J Mol Sci. 2024;25:11686.","journal-title":"Int J Mol Sci"},{"key":"8358_CR16","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1016\/j.chembiol.2024.08.006","volume":"31","author":"MJ Niphakis","year":"2024","unstructured":"Niphakis MJ, Cravatt BF. Ligand discovery by activity-based protein profiling. Cell Chem Biol. 2024;31:1636\u201351.","journal-title":"Cell Chem Biol"},{"key":"8358_CR17","doi-asserted-by":"publisher","first-page":"100164","DOI":"10.1016\/j.crphar.2023.100164","volume":"5","author":"EOJ Porta","year":"2023","unstructured":"Porta EOJ, Steel PG. Activity-based protein profiling: A graphical review. Curr Res Pharmacol Drug Discov. 2023;5:100164.","journal-title":"Curr Res Pharmacol Drug Discov"},{"key":"8358_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s42003-020-0795-6","volume":"3","author":"KA Ball","year":"2020","unstructured":"Ball KA, Webb KJ, Coleman SJ, Cozzolino KA, Jacobsen J, Jones KR, et al. An isothermal shift assay for proteome scale drug-target identification. Commun Biol. 2020;3:75.","journal-title":"Commun Biol"},{"key":"8358_CR19","doi-asserted-by":"publisher","first-page":"154862","DOI":"10.1016\/j.phymed.2023.154862","volume":"116","author":"Y Tu","year":"2023","unstructured":"Tu Y, Tan L, Tao H, Li Y, Liu H. Cetsa and Thermal Proteome Profiling Strategies for Target Identification and Drug Discovery of Natural Products. Phytomedicine. 2023;116:154862.","journal-title":"Phytomedicine"},{"key":"8358_CR20","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.7150\/thno.68804","volume":"12","author":"Z Cui","year":"2022","unstructured":"Cui Z, Li C, Chen P, Yang H. An update of label-free protein target identification methods for natural active products. Theranostics. 2022;12:1829\u201354.","journal-title":"Theranostics"},{"key":"8358_CR21","doi-asserted-by":"publisher","first-page":"156994","DOI":"10.1016\/j.phymed.2025.156994","volume":"145","author":"L Ke","year":"2025","unstructured":"Ke L, Zheng Z, Ye S, Zhong C, Lin Q, Hu Y, et al. Tanshinone I alleviates post-ischemic myocardial injury by targeting TGFBR1 and modulating the TGF-\u03b2 signaling pathway. Phytomedicine. 2025;145:156994.","journal-title":"Phytomedicine"},{"key":"8358_CR22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","volume":"630","author":"J Abramson","year":"2024","unstructured":"Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024;630:493\u2013500.","journal-title":"Nature"},{"key":"8358_CR23","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1021\/np300446c","volume":"75","author":"J-E Huh","year":"2012","unstructured":"Huh J-E, Kang JW, Nam D, Baek Y-H, Choi D-Y, Park D-S, et al. Melittin suppresses VEGF-A-induced tumor growth by blocking VEGFR-2 and the COX-2-mediated MAPK signaling pathway. J Nat Prod. 2012;75:1922\u20139.","journal-title":"J Nat Prod"},{"key":"8358_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jgr.2024.02.001","volume":"48","author":"R Xie","year":"2024","unstructured":"Xie R, Li C, Zhong C, Lin Z, Li S, Chen B, et al. Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg1 against myocardial ischemia. J Ginseng Res. 2024;48:395\u2013404.","journal-title":"J Ginseng Res"},{"key":"8358_CR25","doi-asserted-by":"crossref","unstructured":"Zhong C, Ke L, Hu F, Lin Z, Ye S, Zheng Z, et al. Ginsenoside Rb1 inhibits cardiomyocyte apoptosis and rescues ischemic myocardium by targeting Caspase-3. J Pharm Anal. 2024;101142.","DOI":"10.1016\/j.jpha.2024.101142"},{"key":"8358_CR26","doi-asserted-by":"publisher","first-page":"e80721","DOI":"10.1371\/journal.pone.0080721","volume":"8","author":"M Liu","year":"2013","unstructured":"Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, et al. Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS ONE. 2013;8:e80721.","journal-title":"PLoS ONE"},{"key":"8358_CR27","doi-asserted-by":"publisher","first-page":"15485","DOI":"10.1073\/pnas.0604104103","volume":"103","author":"T Crotty","year":"2006","unstructured":"Crotty T, Cai J, Sakane F, Taketomi A, Prescott SM, Topham MK. Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2006;103:15485\u201390.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8358_CR28","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/med.21963","volume":"43","author":"W Zhao","year":"2023","unstructured":"Zhao W, Zheng X, Tang PY, Li H, Liu X, Zhong J, et al. Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Med Res Rev. 2023;43:1778\u2013808.","journal-title":"Med Res Rev"},{"key":"8358_CR29","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3390\/jfb14090466","volume":"14","author":"A Crintea","year":"2023","unstructured":"Crintea A, Constantin A-M, Motofelea AC, Crivii C-B, Velescu MA, Co\u0219eriu RL, et al. Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer. J Funct Biomater. 2023;14:466.","journal-title":"J Funct Biomater"},{"key":"8358_CR30","doi-asserted-by":"publisher","first-page":"105583","DOI":"10.1016\/j.phrs.2021.105583","volume":"167","author":"R-F Dong","year":"2021","unstructured":"Dong R-F, Zhu M-L, Liu M-M, Xu Y-T, Yuan L-L, Bian J, et al. EGFR mutation mediates resistance to EGFR tyrosine kinase inhibitors in NSCLC: From molecular mechanisms to clinical research. Pharmacol Res. 2021;167:105583.","journal-title":"Pharmacol Res"},{"key":"8358_CR31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12964-023-01082-8","volume":"21","author":"Y Li","year":"2023","unstructured":"Li Y, Mao T, Wang J, Zheng H, Hu Z, Cao P, et al. Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer. Cell Commun Signal CCS. 2023;21:71.","journal-title":"Cell Commun Signal CCS"},{"key":"8358_CR32","doi-asserted-by":"publisher","first-page":"108149","DOI":"10.1016\/j.toxicon.2024.108149","volume":"251","author":"S Xie","year":"2024","unstructured":"Xie S, Han S, Gong J, Feng Z, Sun Y, Yao H, et al. Bee venom prompts the inhibition of gefitinib on proliferation, migration, and invasion of non-small cell lung cancer cells via EGFR-mediated autophagy. Toxicon. 2024;251:108149.","journal-title":"Toxicon"},{"key":"8358_CR33","doi-asserted-by":"publisher","first-page":"103077","DOI":"10.1016\/j.tice.2025.103077","volume":"97","author":"P Shi","year":"2025","unstructured":"Shi P, Han S, Sun Y, Li M, Xu X. Bee venom alleviates isoproterenol-induced cardiac hypertrophy via JAK2\/NF-\u03baB signaling cascade. Tissue Cell. 2025;97:103077.","journal-title":"Tissue Cell"},{"key":"8358_CR34","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.1007\/s12010-021-03653-2","volume":"193","author":"H-S Lee","year":"2021","unstructured":"Lee H-S, Kim YS, Lee K-S, Seo H-S, Lee C-Y, Kim KK. Detoxification of Bee Venom Increases Its Anti-inflammatory Activity and Decreases Its Cytotoxicity and Allergenic Activity. Appl Biochem Biotechnol. 2021;193:4068\u201382.","journal-title":"Appl Biochem Biotechnol"},{"key":"8358_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.canlet.2017.05.010","volume":"402","author":"I Rady","year":"2017","unstructured":"Rady I, Siddiqui IA, Rady M, Mukhtar H. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Lett. 2017;402:16\u201331.","journal-title":"Cancer Lett"},{"key":"8358_CR36","doi-asserted-by":"publisher","first-page":"5212","DOI":"10.1021\/bi300476v","volume":"51","author":"Y Kim","year":"2012","unstructured":"Kim Y, Li Z, Apetri M, Luo B, Settleman JE, Anderson KS. Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib. Biochemistry. 2012;51:5212\u201322.","journal-title":"Biochemistry"},{"key":"8358_CR37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3892\/ol.2022.13229","volume":"23","author":"X Ji","year":"2022","unstructured":"Ji X, Ma H, Du Y. Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy. Oncol Lett. 2022;23:109.","journal-title":"Oncol Lett"},{"key":"8358_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4161\/auto.2.2.2458","volume":"2","author":"J Botti","year":"2006","unstructured":"Botti J, Djavaheri-Mergny M, Pilatte Y, Codogno P. Autophagy Signaling and the Cogwheels of Cancer. Autophagy. 2006;2:67\u201373.","journal-title":"Autophagy"},{"key":"8358_CR39","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.omto.2021.10.009","volume":"23","author":"W Lin","year":"2021","unstructured":"Lin W, Wan X, Sun A, Zhou M, Chen X, Li Y, et al. RUNX1\/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1. Mol Ther - Oncolytics. 2021;23:387\u2013401.","journal-title":"Mol Ther - Oncolytics"},{"key":"8358_CR40","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"CH Jung","year":"2010","unstructured":"Jung CH, Ro S-H, Cao J, Otto NM, Kim D-H. mTOR regulation of autophagy. FEBS Lett. 2010;584:1287\u201395.","journal-title":"FEBS Lett"},{"key":"8358_CR41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.canlet.2019.10.030","volume":"469","author":"M Wu","year":"2020","unstructured":"Wu M, Zhang P. EGFR-mediated autophagy in tumourigenesis and therapeutic resistance. Cancer Lett. 2020;469:207\u201316.","journal-title":"Cancer Lett"},{"key":"8358_CR42","doi-asserted-by":"publisher","first-page":"4352","DOI":"10.1016\/j.molcel.2023.10.042","volume":"83","author":"W Zhang","year":"2023","unstructured":"Zhang W, Dai J, Hou G, Liu H, Zheng S, Wang X, et al. SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation. Mol Cell. 2023;83:4352\u2013e43698.","journal-title":"Mol Cell"},{"key":"8358_CR43","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1186\/s12967-025-06903-7","volume":"23","author":"Y Wang","year":"2025","unstructured":"Wang Y, Li X, Zou Z, Yang W, Qian M, Zhou C, et al. Melittin inhibits NSCLC metastasis by targeting USP10 and promoting RNF20-mediated ubiquitination and degradation of PSMA7. J Transl Med. 2025;23:1312.","journal-title":"J Transl Med"},{"key":"8358_CR44","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nature18600","volume":"534","author":"E Manchado","year":"2016","unstructured":"Manchado E, Weissmueller S, Morris JP, Chen C-C, Wullenkord R, Lujambio A, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016;534:647\u201351.","journal-title":"Nature"},{"key":"8358_CR45","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nature11156","volume":"486","author":"S Misale","year":"2012","unstructured":"Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012;486:532\u20136.","journal-title":"Nature"},{"key":"8358_CR46","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.3390\/biomedicines13061415","volume":"13","author":"P Thongpon","year":"2025","unstructured":"Thongpon P, Tang M, Cong Z. Peptide-Based Nanoparticle for Tumor Therapy. Biomedicines. 2025;13:1415.","journal-title":"Biomedicines"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08358-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08358-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08358-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:03:48Z","timestamp":1786968228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08358-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8358"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08358-w","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"9 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures involving animals were reviewed and approved by the Animal Ethics Committee of the College of Animal Sciences, Fujian Agriculture and Forestry University (Approval No. PZCASFAFU23024).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree to submit the research article for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1058"}}