{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:30:36Z","timestamp":1786581036349,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012578","name":"Natural Science Foundation of Nantong University","doi-asserted-by":"publisher","award":["2023JY022"],"award-info":[{"award-number":["2023JY022"]}],"id":[{"id":"10.13039\/501100012578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012578","name":"Natural Science Foundation of Nantong University","doi-asserted-by":"publisher","award":["2023LY016"],"award-info":[{"award-number":["2023LY016"]}],"id":[{"id":"10.13039\/501100012578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013322","name":"Yancheng Agricultural Science and Technology","doi-asserted-by":"publisher","award":["DYKJ-202101"],"award-info":[{"award-number":["DYKJ-202101"]}],"id":[{"id":"10.13039\/501100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["QNZ2023069"],"award-info":[{"award-number":["QNZ2023069"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08387-5","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:24:28Z","timestamp":1780763068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research on GM1 bound bMSCs loaded with SF hydrogel for spinal cord injury repair"],"prefix":"10.1186","volume":"24","author":[{"given":"Qin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-5245","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"issue":"15","key":"8387_CR1","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1039\/d4bm01586j","volume":"22","author":"R Zhang","year":"2025","unstructured":"Zhang R, Zou C, Jiang L, et al. Repair of spinal cord injury using a time-specific four-dimensional multifunctional hydrogel with anti-inflammatory and neuronal differentiated microenvironments. Biomater Sci Jul. 2025;22(15):4153\u201367. https:\/\/doi.org\/10.1039\/d4bm01586j.","journal-title":"Biomater Sci Jul"},{"key":"8387_CR2","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.2147\/ijn.S522028","volume":"20","author":"A Anjum","year":"2025","unstructured":"Anjum A, Chan AML, Hussain HB, Lokanathan Y. Advanced Therapeutic Approaches Based on Small Extracellular Vehicles (sEVs) For the Regeneration of Spinal Cord Injuries. Int J Nanomed. 2025;20:7415\u201342. https:\/\/doi.org\/10.2147\/ijn.S522028.","journal-title":"Int J Nanomed"},{"key":"8387_CR3","doi-asserted-by":"publisher","unstructured":"K\u00f6hli P, Otto E, Jahn D, et al. Future perspectives in spinal cord repair: brain as saviour? TSCI with concurrent TBI: pathophysiological interaction and impact on MSC treatment. Cells. 2021 Oct;30(11). https:\/\/doi.org\/10.3390\/cells10112955.","DOI":"10.3390\/cells10112955"},{"issue":"1","key":"8387_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ajps.2021.03.003","volume":"17","author":"T Ma","year":"2022","unstructured":"Ma T, Wu J, Mu J, Gao J. Biomaterials reinforced MSCs transplantation for spinal cord injury repair. Asian J Pharm Sci Jan. 2022;17(1):4\u201319. https:\/\/doi.org\/10.1016\/j.ajps.2021.03.003.","journal-title":"Asian J Pharm Sci Jan"},{"key":"8387_CR5","doi-asserted-by":"publisher","unstructured":"Guo S, Redenski I, Levenberg S. Spinal cord repair: from cells and tissue engineering to extracellular vesicles. Cells. 2021 Jul;23(8). https:\/\/doi.org\/10.3390\/cells10081872.","DOI":"10.3390\/cells10081872"},{"key":"8387_CR6","doi-asserted-by":"publisher","unstructured":"Riza YM, Alzahrani FA. Rewiring the Spine-cutting-edge stem cell therapies for spinal cord repair. Int J Mol Sci. 2025 May;23(11). https:\/\/doi.org\/10.3390\/ijms26115048.","DOI":"10.3390\/ijms26115048"},{"issue":"11","key":"8387_CR7","doi-asserted-by":"publisher","first-page":"e1004082","DOI":"10.1371\/journal.pmed.1004082","volume":"20","author":"DD Hodgkiss","year":"2023","unstructured":"Hodgkiss DD, Bhangu GS, Lunny C, et al. Exercise and aerobic capacity in individuals with spinal cord injury: A systematic review with meta-analysis and meta-regression. PLoS Med Nov. 2023;20(11):e1004082. https:\/\/doi.org\/10.1371\/journal.pmed.1004082.","journal-title":"PLoS Med Nov"},{"issue":"1","key":"8387_CR8","doi-asserted-by":"publisher","first-page":"5786","DOI":"10.1038\/s41467-022-33463-x","volume":"2","author":"F Bretheau","year":"2022","unstructured":"Bretheau F, Castellanos-Molina A, B\u00e9langer D, et al. The alarmin interleukin-1\u03b1 triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury. Nat Commun Oct. 2022;2(1):5786. https:\/\/doi.org\/10.1038\/s41467-022-33463-x.","journal-title":"Nat Commun Oct"},{"key":"8387_CR9","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"27","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS, Wilson JR, Nori S, et al. Traumatic spinal cord injury. Nat Rev Dis Primers Apr. 2017;27:3:17018. https:\/\/doi.org\/10.1038\/nrdp.2017.18.","journal-title":"Nat Rev Dis Primers Apr"},{"key":"8387_CR10","doi-asserted-by":"publisher","first-page":"751021","DOI":"10.3389\/fimmu.2021.751021","volume":"12","author":"QM Pang","year":"2021","unstructured":"Pang QM, Chen SY, Xu QJ, et al. Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar. Front Immunol. 2021;12:751021. https:\/\/doi.org\/10.3389\/fimmu.2021.751021.","journal-title":"Front Immunol"},{"issue":"2","key":"8387_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00441-019-03039-1","volume":"377","author":"K Venkatesh","year":"2019","unstructured":"Venkatesh K, Ghosh SK, Mullick M, Manivasagam G, Sen D. Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications. Cell Tissue Res Aug. 2019;377(2):125\u201351. https:\/\/doi.org\/10.1007\/s00441-019-03039-1.","journal-title":"Cell Tissue Res Aug"},{"issue":"24","key":"8387_CR12","doi-asserted-by":"publisher","first-page":"e2501425","DOI":"10.1002\/advs.202501425","volume":"12","author":"C Li","year":"2025","unstructured":"Li C, Shan Y, Zheng S, et al. Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation. Adv Sci (Weinh) Jun. 2025;12(24):e2501425. https:\/\/doi.org\/10.1002\/advs.202501425.","journal-title":"Adv Sci (Weinh) Jun"},{"issue":"8","key":"8387_CR13","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1007\/s12015-022-10436-7","volume":"18","author":"M Yu","year":"2022","unstructured":"Yu M, Wang D, Chen X, Zhong D, Luo J. BMSCs-derived Mitochondria Improve Osteoarthritis by Ameliorating Mitochondrial Dysfunction and Promoting Mitochondrial Biogenesis in Chondrocytes. Stem Cell Rev Rep Dec. 2022;18(8):3092\u2013111. https:\/\/doi.org\/10.1007\/s12015-022-10436-7.","journal-title":"Stem Cell Rev Rep Dec"},{"key":"8387_CR14","doi-asserted-by":"publisher","first-page":"1491327","DOI":"10.1155\/2022\/1491327","volume":"2022","author":"Y Wang","year":"2022","unstructured":"Wang Y, Yang B, Hu P, Lu S, Lei L, Liu L. The Role of Gap Junctions in the Generation of Smooth Muscle Cells from Bone Marrow Mesenchymal Stem Cells. Dis Markers. 2022;2022:1491327. https:\/\/doi.org\/10.1155\/2022\/1491327.","journal-title":"Dis Markers"},{"key":"8387_CR15","doi-asserted-by":"publisher","unstructured":"Naskar D, Sapru S, Ghosh AK, Reis RL, Dey T, Kundu SC. Nonmulberry silk proteins: multipurpose ingredient in bio-functional assembly. Biomed Mater. 2021 Sep;22(6). https:\/\/doi.org\/10.1088\/1748-605X\/ac20a0.","DOI":"10.1088\/1748-605X\/ac20a0"},{"issue":"Pt 1","key":"8387_CR16","doi-asserted-by":"publisher","first-page":"145304","DOI":"10.1016\/j.ijbiomac.2025.145304","volume":"319","author":"L Duan","year":"2025","unstructured":"Duan L, Wang J, Miao Z, et al. Silk fibroin\/dual drugs eluting polydioxanone monofilament braided ureteral stent with antibacterial and anti-stenotic functions. Int J Biol Macromol Aug. 2025;319(Pt 1):145304. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145304.","journal-title":"Int J Biol Macromol Aug"},{"issue":"8","key":"8387_CR17","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1021\/acsbiomaterials.1c00493","volume":"9","author":"MK DeBari","year":"2021","unstructured":"DeBari MK, King CI 3rd, Altgold TA, Abbott RD. Silk Fibroin as a Green Material. ACS Biomater Sci Eng Aug. 2021;9(8):3530\u201344. https:\/\/doi.org\/10.1021\/acsbiomaterials.1c00493.","journal-title":"ACS Biomater Sci Eng Aug"},{"issue":"5","key":"8387_CR18","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s11427-021-1985-5","volume":"65","author":"F Tang","year":"2022","unstructured":"Tang F, Tang J, Zhao Y, et al. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Sci China Life Sci May. 2022;65(5):909\u201326. https:\/\/doi.org\/10.1007\/s11427-021-1985-5.","journal-title":"Sci China Life Sci May"},{"issue":"9","key":"8387_CR19","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.4103\/1673-5374.276340","volume":"15","author":"WS Deng","year":"2020","unstructured":"Deng WS, Ma K, Liang B, et al. Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury. Neural Regen Res Sep. 2020;15(9):1686\u2013700. https:\/\/doi.org\/10.4103\/1673-5374.276340.","journal-title":"Neural Regen Res Sep"},{"issue":"2","key":"8387_CR20","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1039\/d0tb02033h","volume":"21","author":"M Yao","year":"2021","unstructured":"Yao M, Li J, Zhang J, et al. Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury. J Mater Chem B Jan. 2021;21(2):440\u201352. https:\/\/doi.org\/10.1039\/d0tb02033h.","journal-title":"J Mater Chem B Jan"},{"key":"8387_CR21","doi-asserted-by":"publisher","unstructured":"Chiricozzi E, Lunghi G, Di Biase E, Fazzari M, Sonnino S, Mauri L. GM1 ganglioside is a key factor in maintaining the Mammalian neuronal functions avoiding neurodegeneration. Int J Mol Sci. 2020 Jan;29(3). https:\/\/doi.org\/10.3390\/ijms21030868.","DOI":"10.3390\/ijms21030868"},{"issue":"3","key":"8387_CR22","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s12035-015-9136-z","volume":"53","author":"M Aureli","year":"2016","unstructured":"Aureli M, Mauri L, Ciampa MG, et al. GM1 Ganglioside: Past Studies and Future Potential. Mol Neurobiol Apr. 2016;53(3):1824\u201342. https:\/\/doi.org\/10.1007\/s12035-015-9136-z.","journal-title":"Mol Neurobiol Apr"},{"issue":"8","key":"8387_CR23","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1021\/acsbiomaterials.9b00621","volume":"12","author":"Z Ding","year":"2019","unstructured":"Ding Z, Zhou M, Zhou Z, et al. Injectable Silk Nanofiber Hydrogels for Sustained Release of Small-Molecule Drugs and Vascularization. ACS Biomater Sci Eng Aug. 2019;12(8):4077\u201388. https:\/\/doi.org\/10.1021\/acsbiomaterials.9b00621.","journal-title":"ACS Biomater Sci Eng Aug"},{"key":"8387_CR24","doi-asserted-by":"publisher","first-page":"212743","DOI":"10.1016\/j.bioadv.2022.212743","volume":"135","author":"J Zhang","year":"2022","unstructured":"Zhang J, Li S, Yang Z, et al. Implantation of injectable SF hydrogel with sustained hydrogen sulfide delivery reduces neuronal pyroptosis and enhances functional recovery after severe intracerebral hemorrhage. Biomater Adv Apr. 2022;135:212743. https:\/\/doi.org\/10.1016\/j.bioadv.2022.212743.","journal-title":"Biomater Adv Apr"},{"issue":"10","key":"8387_CR25","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1039\/c4bm00214h","volume":"26","author":"Y Liu","year":"2014","unstructured":"Liu Y, Ling S, Wang S, Chen X, Shao Z. Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure. Biomater Sci Oct. 2014;26(10):1338\u201342. https:\/\/doi.org\/10.1039\/c4bm00214h.","journal-title":"Biomater Sci Oct"},{"issue":"10","key":"8387_CR26","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.4103\/1673-5374.391194","volume":"1","author":"Z Liang","year":"2024","unstructured":"Liang Z, Yang Z, Xie H, et al. Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization. Neural Regen Res Oct. 2024;1(10):2259\u201369. https:\/\/doi.org\/10.4103\/1673-5374.391194.","journal-title":"Neural Regen Res Oct"},{"key":"8387_CR27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.intimp.2018.11.029","volume":"66","author":"W Dai","year":"2019","unstructured":"Dai W, Wang X, Teng H, Li C, Wang B, Wang J. Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. Int Immunopharmacol Jan. 2019;66:215\u201323. https:\/\/doi.org\/10.1016\/j.intimp.2018.11.029.","journal-title":"Int Immunopharmacol Jan"},{"key":"8387_CR28","doi-asserted-by":"publisher","unstructured":"Mojarad N, Doyle D, Garmo LG, et al. Sex and strain-specific variations in motor recovery following compression spinal cord injury: comparison of sprague-dawley and wistar rats. Brain Sci. 2025 Feb;13(2). https:\/\/doi.org\/10.3390\/brainsci15020191.","DOI":"10.3390\/brainsci15020191"},{"issue":"3","key":"8387_CR29","first-page":"411","volume":"1","author":"L Zhang","year":"2022","unstructured":"Zhang L, Han P. Neural stem cell-derived exosomes suppress neuronal cell apoptosis by activating autophagy via miR-374-5p\/STK-4 axis in spinal cord injury. J Musculoskelet Neuronal Interact. Sep 2022;1(3):411\u201321.","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"1","key":"8387_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/brain\/awaa360","volume":"12","author":"T Zrzavy","year":"2021","unstructured":"Zrzavy T, Schwaiger C, Wimmer I, et al. Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury. Brain Feb. 2021;12(1):144\u201361. https:\/\/doi.org\/10.1093\/brain\/awaa360.","journal-title":"Brain Feb"},{"issue":"12","key":"8387_CR31","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1136\/jme.2007.022525","volume":"34","author":"M Legge","year":"2008","unstructured":"Legge M, Jones LM. Stem cell spinal cord regeneration: first do no harm. J Med Ethics Dec. 2008;34(12):838\u20139. https:\/\/doi.org\/10.1136\/jme.2007.022525.","journal-title":"J Med Ethics Dec"},{"issue":"23","key":"8387_CR32","doi-asserted-by":"publisher","first-page":"10146","DOI":"10.1021\/acs.nanolett.1c04394","volume":"8","author":"XJ Wang","year":"2021","unstructured":"Wang XJ, Peng CH, Zhang S, et al. Correction to Polysialic-Acid-Based Micelles Promote Neural Regeneration in Spinal Cord Injury Therapy. Nano Lett Dec. 2021;8(23):10146\u20137. https:\/\/doi.org\/10.1021\/acs.nanolett.1c04394.","journal-title":"Nano Lett Dec"},{"key":"8387_CR33","doi-asserted-by":"publisher","unstructured":"Zhang J, Li X, Guo L, et al. 3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury. Biofabrication. 2024 May;9(3). https:\/\/doi.org\/10.1088\/1758-5090\/ad39a7.","DOI":"10.1088\/1758-5090\/ad39a7"},{"issue":"8","key":"8387_CR34","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/nn.3163","volume":"26","author":"Z Kokaia","year":"2012","unstructured":"Kokaia Z, Martino G, Schwartz M, Lindvall O. Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat Neurosci. Jul. 2012;26(8):1078\u201387. https:\/\/doi.org\/10.1038\/nn.3163.","journal-title":"Jul"},{"issue":"6","key":"8387_CR35","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1089\/neu.2018.5843","volume":"19","author":"AD Levi","year":"2019","unstructured":"Levi AD, Anderson KD, Okonkwo DO, et al. Clinical Outcomes from a Multi-Center Study of Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury. J Neurotrauma Mar. 2019;19(6):891\u2013902. https:\/\/doi.org\/10.1089\/neu.2018.5843.","journal-title":"J Neurotrauma Mar"},{"issue":"3","key":"8387_CR36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s12015-011-9228-8","volume":"7","author":"C Pontikoglou","year":"2011","unstructured":"Pontikoglou C, Deschaseaux F, Senseb\u00e9 L, Papadaki HA. Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev Rep Sep. 2011;7(3):569\u201389. https:\/\/doi.org\/10.1007\/s12015-011-9228-8.","journal-title":"Stem Cell Rev Rep Sep"},{"key":"8387_CR37","doi-asserted-by":"publisher","unstructured":"Guo Z. Ganglioside GM1 and the central nervous system. Int J Mol Sci. 2023 May;31(11). https:\/\/doi.org\/10.3390\/ijms24119558.","DOI":"10.3390\/ijms24119558"},{"key":"8387_CR38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/bs.apcsb.2021.08.003","volume":"128","author":"F Azzaz","year":"2022","unstructured":"Azzaz F, Yahi N, Di Scala C, Chahinian H, Fantini J. Ganglioside binding domains in proteins: Physiological and pathological mechanisms. Adv Protein Chem Struct Biol. 2022;128:289\u2013324. https:\/\/doi.org\/10.1016\/bs.apcsb.2021.08.003.","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"2","key":"8387_CR39","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1021\/acsbiomaterials.8b01024","volume":"11","author":"N Gorenkova","year":"2019","unstructured":"Gorenkova N, Osama I, Seib FP, Carswell HVO. In Vivo Evaluation of Engineered Self-Assembling Silk Fibroin Hydrogels after Intracerebral Injection in a Rat Stroke Model. ACS Biomater Sci Eng Feb. 2019;11(2):859\u201369. https:\/\/doi.org\/10.1021\/acsbiomaterials.8b01024.","journal-title":"ACS Biomater Sci Eng Feb"},{"issue":"25","key":"8387_CR40","doi-asserted-by":"publisher","first-page":"11719","DOI":"10.7150\/thno.47682","volume":"10","author":"Q Yao","year":"2020","unstructured":"Yao Q, Lan QH, Jiang X, et al. Bioinspired biliverdin\/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing. Theranostics. 2020;10(25):11719\u201336. https:\/\/doi.org\/10.7150\/thno.47682.","journal-title":"Theranostics"},{"issue":"2","key":"8387_CR41","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1039\/c9tb01971e","volume":"14","author":"J Feng","year":"2020","unstructured":"Feng J, Wu Y, Chen W, et al. Sustained release of bioactive IGF-1 from a silk fibroin microsphere-based injectable alginate hydrogel for the treatment of myocardial infarction. J Mater Chem B Jan. 2020;14(2):308\u201315. https:\/\/doi.org\/10.1039\/c9tb01971e.","journal-title":"J Mater Chem B Jan"},{"key":"8387_CR42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.actbio.2022.12.048","volume":"158","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang Z, Zhang Y, et al. Construction of adhesive and bioactive silk fibroin hydrogel for treatment of spinal cord injury. Acta Biomater Mar 1. 2023;158:178\u201389. https:\/\/doi.org\/10.1016\/j.actbio.2022.12.048.","journal-title":"Acta Biomater Mar 1"},{"issue":"7","key":"8387_CR43","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1634\/stemcells.2007-0921","volume":"26","author":"L Katsimpardi","year":"2008","unstructured":"Katsimpardi L, Gaitanou M, Malnou CE, et al. BM88\/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. Stem Cells Jul. 2008;26(7):1796\u2013807. https:\/\/doi.org\/10.1634\/stemcells.2007-0921.","journal-title":"Stem Cells Jul"},{"key":"8387_CR44","doi-asserted-by":"publisher","first-page":"102264","DOI":"10.1016\/j.npep.2022.102264","volume":"95","author":"C Chen","year":"2022","unstructured":"Chen C, Yu Q, Huang Y, et al. Research on the function of the Cend1 regulatory mechanism on p75NTR signaling in spinal cord injury. Neuropeptides Oct. 2022;95:102264. https:\/\/doi.org\/10.1016\/j.npep.2022.102264.","journal-title":"Neuropeptides Oct"},{"key":"8387_CR45","doi-asserted-by":"publisher","unstructured":"Lin D, Li M, Wang L, et al. Multifunctional hydrogel based on silk fibroin promotes tissue repair and regeneration. Adv Funct Mater. 2024 Sep 1;34(39):2405255. https:\/\/doi.org\/10.1002\/adfm.202405255.","DOI":"10.1002\/adfm.202405255"},{"key":"8387_CR46","doi-asserted-by":"publisher","first-page":"1431420","DOI":"10.3389\/fbioe.2024.1431420","volume":"12","author":"J Bai","year":"2024","unstructured":"Bai J, Liu G, Gao Y, Zhang X, Niu G, Zhang H. Co-culturing neural and bone mesenchymal stem cells in photosensitive hydrogel enhances spinal cord injury repair. Front Bioeng Biotechnol. 2024;12:1431420. https:\/\/doi.org\/10.3389\/fbioe.2024.1431420.","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"8387_CR47","doi-asserted-by":"publisher","first-page":"e19782","DOI":"10.1371\/journal.pone.0019782","volume":"6","author":"D Cigognini","year":"2011","unstructured":"Cigognini D, Satta A, Colleoni B, et al. Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold. PLoS ONE. 2011;6(5):e19782. https:\/\/doi.org\/10.1371\/journal.pone.0019782.","journal-title":"PLoS ONE"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08387-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08387-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08387-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:18:04Z","timestamp":1786580284000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08387-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8387"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08387-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"2 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal procedures were approved by the Institutional Animal Care and Use Committee of Nantong University (Approval No. P20230311-043) and were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1044"}}