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Among the key mechanisms underlying Osteoporosis progression, disruption of the bone immune microenvironment has emerged as a critical scientific issue. Heat shock proteins (HSPs), as highly conserved molecular chaperones and stress-responsive proteins, not only prevent protein misfolding and aggregation under stress conditions to maintain protein homeostasis, but also participate in immune signaling and adaptive stress responses, thereby playing important roles in preserving bone metabolic homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body of the abstract<\/jats:title>\n                    <jats:p>This review aims to systematically examine the roles of HSP families\u2014HSPB, HSP40, HSP70, HSP90, and HSP110\u2014in bone remodeling, the balance between osteogenesis and osteoclastogenesis, and the interaction between endoplasmic reticulum stress and mitochondrial energy metabolism. The review also highlights the dual roles of HSPs in regulating bone immune homeostasis. HSPs participate at the cellular level in regulating osteoblast, osteoclast, and bone marrow mesenchymal stem cell function. Current evidence suggests that HSPs act as both molecular chaperones and stress-responsive immune modulators, regulating the balance between bone formation and bone resorption and remodeling the bone immune microenvironment. This review also summarizes HSP-targeted therapeutic strategies, including small molecules, natural products, neutralizing antibodies, physical stimulation, and gene- and cell-based therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Research on HSPs is shifting from molecular mechanisms toward precision intervention. Future studies should integrate the \u201cbone-muscle-immune axis\u201d with artificial intelligence and multi-omics technologies to construct a \u201cheat shock response-bone immune\u201d network, identify novel therapeutic targets, and promote personalized prevention and treatment of osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-026-08389-3","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:57:16Z","timestamp":1780923436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heat shock protein\u2013mediated remodeling of the bone immune microenvironment: mechanisms and precision therapeutic strategies for osteoporosis"],"prefix":"10.1186","volume":"24","author":[{"given":"Jinyang","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-4899","authenticated-orcid":false,"given":"Haihong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"10169","key":"8389_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","volume":"393","author":"JE Compston","year":"2019","unstructured":"Compston JE, Mcclung MR, Leslie WD(London, England), Osteoporosis. 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