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Sites received local institutional review board (IRB)\/ethics committee approvals, and each patient provided written informed consent before study entry including provision of serum samples. All specimens were deidentified. The George Washington University IRB provided additional review and approved these investigations.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All financial and non-financial competing interests must be declared in this section.\n                      KG: none. AC: none. HK: receives consulting fees from Novartis, UCB Pharmaceuticals, Kite Pharmaceuticals, Canopy Immunotherapeutics, and Merck. Argenx provides an unrestricted educational grant to George Washington University. 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