{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:07:50Z","timestamp":1788739670082,"version":"build-2803163510"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273083"],"award-info":[{"award-number":["82273083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272733"],"award-info":[{"award-number":["82272733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianiin Science and Technology Program","award":["24KPXMRC00140"],"award-info":[{"award-number":["24KPXMRC00140"]}]},{"name":"The National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine","award":["QZ23-9"],"award-info":[{"award-number":["QZ23-9"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08484-5","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:57:25Z","timestamp":1782136645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating CD28\u2212KLRG1+CD8+ T cells involve in systemic and local immunity that predicts chemoimmunotherapy outcomes in advanced NSCLC"],"prefix":"10.1186","volume":"24","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-0403","authenticated-orcid":false,"given":"Cihui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"21","key":"8484_CR1","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1056\/NEJMoa1810865","volume":"379","author":"L Paz-Ares","year":"2018","unstructured":"Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gumus M, Mazieres J, et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med. 2018;379(21):2040\u201351.","journal-title":"N Engl J Med"},{"issue":"7","key":"8484_CR2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S1470-2045(19)30167-6","volume":"20","author":"H West","year":"2019","unstructured":"West H, McCleod M, Hussein M, Morabito A, Rittmeyer A, Conter HJ, et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20(7):924\u201337.","journal-title":"Lancet Oncol"},{"key":"8484_CR3","doi-asserted-by":"crossref","unstructured":"Kim CG, Kim G, Kim KH, Park S, Shin S, Yeo D et al. Distinct exhaustion features of T lymphocytes shape the tumor-immune microenvironment with therapeutic implication in patients with non-small-cell lung cancer. J Immunother Cancer. 2021;9(12).","DOI":"10.1136\/jitc-2021-002780"},{"issue":"4","key":"8484_CR4","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1200\/JCO.22.02270","volume":"41","author":"JR Brahmer","year":"2023","unstructured":"Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, et al. Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates. J Clin Oncol. 2023;41(4):715\u201323.","journal-title":"J Clin Oncol"},{"issue":"3","key":"8484_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41590-019-0312-6","volume":"20","author":"BC Miller","year":"2019","unstructured":"Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, et al. Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade. Nat Immunol. 2019;20(3):326\u201336.","journal-title":"Nat Immunol"},{"key":"8484_CR6","doi-asserted-by":"crossref","unstructured":"Chun B, Pucilowska J, Chang S, Kim I, Nikitin B, Koguchi Y et al. Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer. J Immunother Cancer. 2022;10(1).","DOI":"10.1136\/jitc-2021-004033"},{"issue":"1","key":"8484_CR7","doi-asserted-by":"publisher","first-page":"2025668","DOI":"10.1080\/2162402X.2022.2025668","volume":"11","author":"C Yan","year":"2022","unstructured":"Yan C, Ma X, Guo Z, Wei X, Han D, Zhang T, et al. Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade. Oncoimmunology. 2022;11(1):2025668.","journal-title":"Oncoimmunology"},{"key":"8484_CR8","doi-asserted-by":"publisher","first-page":"1371559","DOI":"10.3389\/fimmu.2024.1371559","volume":"15","author":"J Hou","year":"2024","unstructured":"Hou J, Yang X, Xie S, Zhu B, Zha H. Circulating T cells: a promising biomarker of anti-PD-(L)1 therapy. Front Immunol. 2024;15:1371559.","journal-title":"Front Immunol"},{"key":"8484_CR9","doi-asserted-by":"crossref","unstructured":"Hwang M, Canzoniero JV, Rosner S, Zhang G, White JR, Belcaid Z et al. Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy. J Immunother Cancer. 2022;10(6).","DOI":"10.1136\/jitc-2022-004688"},{"issue":"2","key":"8484_CR10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1158\/1078-0432.CCR-20-1420","volume":"27","author":"R Ferrara","year":"2021","unstructured":"Ferrara R, Naigeon M, Auclin E, Duchemann B, Cassard L, Jouniaux JM, et al. Circulating T-cell Immunosenescence in Patients with Advanced Non-small Cell Lung Cancer Treated with Single-agent PD-1\/PD-L1 Inhibitors or Platinum-based Chemotherapy. Clin Cancer Res. 2021;27(2):492\u2013503.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"8484_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41408-023-00920-9","volume":"13","author":"S Zanwar","year":"2023","unstructured":"Zanwar S, Jacob EK, Greiner C, Pavelko K, Strausbauch M, Anderson E, et al. The immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant. Blood Cancer J. 2023;13(1):151.","journal-title":"Blood Cancer J"},{"key":"8484_CR12","doi-asserted-by":"crossref","unstructured":"Slaets H, Veeningen N, de Keizer PLJ, Hellings N, Hendrix S. Are immunosenescent T cells really senescent? Aging Cell. 2024:e14300.","DOI":"10.1111\/acel.14300"},{"issue":"1","key":"8484_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s40425-019-0608-y","volume":"7","author":"A Kunert","year":"2019","unstructured":"Kunert A, Basak EA, Hurkmans DP, Balcioglu HE, Klaver Y, van Brakel M, et al. CD45RA(+)CCR7(-) CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab. J Immunother Cancer. 2019;7(1):149.","journal-title":"J Immunother Cancer"},{"issue":"6230","key":"8484_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1126\/science.aaa1348","volume":"348","author":"NA Rizvi","year":"2015","unstructured":"Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124\u20138.","journal-title":"Science"},{"issue":"4","key":"8484_CR15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.4049\/jimmunol.1901512","volume":"205","author":"KR Renkema","year":"2020","unstructured":"Renkema KR, Huggins MA, Borges da Silva H, Knutson TP, Henzler CM, Hamilton SE. KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory. J Immunol. 2020;205(4):1059\u201369.","journal-title":"J Immunol"},{"issue":"96","key":"8484_CR16","doi-asserted-by":"publisher","first-page":"eadj8356","DOI":"10.1126\/sciimmunol.adj8356","volume":"9","author":"ED Lucas","year":"2024","unstructured":"Lucas ED, Huggins MA, Peng C, O\u2019Connor C, Gress AR, Thefaine CE, et al. Circulating KLRG1(+) long-lived effector memory T cells retain the flexibility to become tissue resident. Sci Immunol. 2024;9(96):eadj8356.","journal-title":"Sci Immunol"},{"key":"8484_CR17","doi-asserted-by":"crossref","unstructured":"Skrajnowska D, Bobrowska-Korczak B. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients. 2019;11(10).","DOI":"10.3390\/nu11102273"},{"issue":"1","key":"8484_CR18","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12957-019-1617-5","volume":"17","author":"Y Wang","year":"2019","unstructured":"Wang Y, Sun Z, Li A, Zhang Y. Association between serum zinc levels and lung cancer: a meta-analysis of observational studies. World J Surg Oncol. 2019;17(1):78.","journal-title":"World J Surg Oncol"},{"issue":"5","key":"8484_CR19","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1007\/s12011-023-03818-6","volume":"202","author":"R Sugimoto","year":"2024","unstructured":"Sugimoto R, Lee L, Tanaka Y, Morita Y, Hijioka M, Hisano T, et al. Zinc Deficiency as a General Feature of Cancer: a Review of the Literature. Biol Trace Elem Res. 2024;202(5):1937\u201347.","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"8484_CR20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10534-024-00583-4","volume":"37","author":"D Coradduzza","year":"2024","unstructured":"Coradduzza D, Congiargiu A, Azara E, Mammani IMA, De Miglio MR, Zinellu A, et al. Heavy metals in biological samples of cancer patients: a systematic literature review. Biometals. 2024;37(4):803\u201317.","journal-title":"Biometals"},{"issue":"15","key":"8484_CR21","doi-asserted-by":"publisher","first-page":"10497","DOI":"10.1021\/acs.jmedchem.3c00603","volume":"66","author":"LS Liao","year":"2023","unstructured":"Liao LS, Chen Y, Hou C, Liu YH, Su GF, Liang H, et al. Potent Zinc(II)-Based Immunogenic Cell Death Inducer Triggered by ROS-Mediated ERS and Mitochondrial Ca(2+) Overload. J Med Chem. 2023;66(15):10497\u2013509.","journal-title":"J Med Chem"},{"issue":"25","key":"8484_CR22","doi-asserted-by":"publisher","first-page":"e2311056","DOI":"10.1002\/smll.202311056","volume":"20","author":"PY Huang","year":"2024","unstructured":"Huang PY, Liang SY, Xiang Y, Li MR, Wang MR, Liu LH. Endoplasmic Reticulum-Targeting Self-Assembly Nanosheets Promote Autophagy and Regulate Immunosuppressive Tumor Microenvironment for Efficient Photodynamic Immunotherapy. Small. 2024;20(25):e2311056.","journal-title":"Small"},{"issue":"27","key":"8484_CR23","doi-asserted-by":"publisher","first-page":"e2302967","DOI":"10.1002\/advs.202302967","volume":"10","author":"L Ding","year":"2023","unstructured":"Ding L, Liang M, Li Y, Zeng M, Liu M, Ma W, et al. Zinc-Organometallic Framework Vaccine Controlled-Release Zn(2+) Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy. Adv Sci (Weinh). 2023;10(27):e2302967.","journal-title":"Adv Sci (Weinh)"},{"issue":"2","key":"8484_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1097\/HEP.0000000000000629","volume":"80","author":"D Yang","year":"2024","unstructured":"Yang D, Tian T, Li X, Zhang B, Qi L, Zhang F, et al. ZNT1 and Zn 2\u2009+\u2009control TLR4 and PD-L1 endocytosis in macrophages to improve chemotherapy efficacy against liver tumor. Hepatology. 2024;80(2):312\u201329.","journal-title":"Hepatology"},{"issue":"21","key":"8484_CR25","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.18632\/aging.204380","volume":"14","author":"W Tang","year":"2022","unstructured":"Tang W, Liu H, Li X, Ooi TC, Rajab NF, Cao H, et al. Efficacy of zinc carnosine in the treatment of colorectal cancer and its potential in combination with immunotherapy in vivo. Aging. 2022;14(21):8688\u201399.","journal-title":"Aging"},{"key":"8484_CR26","doi-asserted-by":"crossref","unstructured":"Jamrozik D, Dutczak R, Machowicz J, Wojtyniak A, Smedowski A, Pietrucha-Dutczak M. Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases. Antioxid (Basel). 2023;12(6).","DOI":"10.3390\/antiox12061251"},{"issue":"1","key":"8484_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","volume":"9","author":"B Chen","year":"2024","unstructured":"Chen B, Yu P, Chan WN, Xie F, Zhang Y, Liang L, et al. Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther. 2024;9(1):6.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"8484_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13045-018-0645-x","volume":"11","author":"M Si","year":"2018","unstructured":"Si M, Lang J. The roles of metallothioneins in carcinogenesis. J Hematol Oncol. 2018;11(1):107.","journal-title":"J Hematol Oncol"},{"issue":"18","key":"8484_CR29","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1038\/sj.onc.1210041","volume":"26","author":"S Zhong","year":"2007","unstructured":"Zhong S, Fields CR, Su N, Pan YX, Robertson KD. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. Oncogene. 2007;26(18):2621\u201334.","journal-title":"Oncogene"},{"key":"8484_CR30","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/1477-7819-11-199","volume":"11","author":"GY Liang","year":"2013","unstructured":"Liang GY, Lu SX, Xu G, Liu XD, Li J, Zhang DS. Expression of metallothionein and Nrf2 pathway genes in lung cancer and cancer-surrounding tissues. World J Surg Oncol. 2013;11:199.","journal-title":"World J Surg Oncol"},{"issue":"6","key":"8484_CR31","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.cell.2016.08.052","volume":"166","author":"M Singer","year":"2016","unstructured":"Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, et al. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016;166(6):1500\u2013e119.","journal-title":"Cell"},{"issue":"1","key":"8484_CR32","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s42255-019-0152-6","volume":"2","author":"J Vijay","year":"2020","unstructured":"Vijay J, Gauthier MF, Biswell RL, Louiselle DA, Johnston JJ, Cheung WA, et al. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat Metab. 2020;2(1):97\u2013109.","journal-title":"Nat Metab"},{"issue":"7","key":"8484_CR33","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41419-022-05057-4","volume":"13","author":"Z Hui","year":"2022","unstructured":"Hui Z, Zhang J, Ren Y, Li X, Yan C, Yu W, et al. Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC). Cell Death Dis. 2022;13(7):607.","journal-title":"Cell Death Dis"},{"issue":"6574","key":"8484_CR34","doi-asserted-by":"publisher","first-page":"abe6474","DOI":"10.1126\/science.abe6474","volume":"374","author":"L Zheng","year":"2021","unstructured":"Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, et al. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science. 2021;374(6574):abe6474.","journal-title":"Science"},{"issue":"6","key":"8484_CR35","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1002\/eji.201847982","volume":"49","author":"F Siracusa","year":"2019","unstructured":"Siracusa F, Durek P, McGrath MA, Sercan-Alp O, Rao A, Du W, et al. CD69(+) memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes. Eur J Immunol. 2019;49(6):966\u20138.","journal-title":"Eur J Immunol"},{"key":"8484_CR36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/978-1-0716-1507-2_6","volume":"2325","author":"R Franzin","year":"2021","unstructured":"Franzin R, Stasi A, Castellano G, Gesualdo L. Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing. Methods Mol Biol. 2021;2325:79\u201395.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"8484_CR37","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1038\/s41467-019-11947-7","volume":"10","author":"C Yang","year":"2019","unstructured":"Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, et al. Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. Nat Commun. 2019;10(1):3931.","journal-title":"Nat Commun"},{"key":"8484_CR38","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/bimj.4710300404","volume":"30","author":"BC Arnold","year":"2007","unstructured":"Arnold BC, Beaver RJ. Estimation of the Number of Classes in a Population. Biom J. 2007;30:413\u201324.","journal-title":"Biom J"},{"key":"8484_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.copbio.2020.07.010","volume":"65","author":"J Chiffelle","year":"2020","unstructured":"Chiffelle J, Genolet R, Perez MA, Coukos G, Zoete V, Harari A. T-cell repertoire analysis and metrics of diversity and clonality. Curr Opin Biotechnol. 2020;65:284\u201395.","journal-title":"Curr Opin Biotechnol"},{"issue":"1","key":"8484_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12865-021-00455-3","volume":"22","author":"L Chen","year":"2021","unstructured":"Chen L, Dong L, Ma Y, Wang J, Qiao D, Tian G, et al. An efficient method to identify virus-specific TCRs for TCR-T cell immunotherapy against virus-associated malignancies. BMC Immunol. 2021;22(1):65.","journal-title":"BMC Immunol"},{"key":"8484_CR41","doi-asserted-by":"crossref","unstructured":"Goncharov MM, Bryushkova EA, Sharaev NI, Skatova VD, Baryshnikova AM, Sharonov GV et al. Pinpointing the tumor-specific T cells via TCR clusters. Elife. 2022;11.","DOI":"10.7554\/eLife.77274"},{"issue":"4","key":"8484_CR42","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00262-021-03047-7","volume":"71","author":"YHF Teng","year":"2022","unstructured":"Teng YHF, Quah HS, Suteja L, Dias JML, Mupo A, Bashford-Rogers RJM, et al. Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures. Cancer Immunol Immunother. 2022;71(4):989\u201398.","journal-title":"Cancer Immunol Immunother"},{"issue":"26","key":"8484_CR43","doi-asserted-by":"publisher","first-page":"39578","DOI":"10.1007\/s11356-022-18957-x","volume":"29","author":"L Chouchene","year":"2022","unstructured":"Chouchene L, Kessabi K, Gueguen MM, Kah O, Pakdel F, Messaoudi I. Interference with zinc homeostasis and oxidative stress induction as probable mechanisms for cadmium-induced embryo-toxicity in zebrafish. Environ Sci Pollut Res Int. 2022;29(26):39578\u201392.","journal-title":"Environ Sci Pollut Res Int"},{"issue":"7","key":"8484_CR44","doi-asserted-by":"publisher","first-page":"e1406","DOI":"10.1002\/cti2.1406","volume":"11","author":"A Khanniche","year":"2022","unstructured":"Khanniche A, Yang Y, Zhang J, Liu S, Xia L, Duan H, et al. Early-like differentiation status of systemic PD-1(+)CD8(+) T cells predicts PD-1 blockade outcome in non-small cell lung cancer. Clin Transl Immunol. 2022;11(7):e1406.","journal-title":"Clin Transl Immunol"},{"issue":"19","key":"8484_CR45","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.1073\/pnas.1705327114","volume":"114","author":"AO Kamphorst","year":"2017","unstructured":"Kamphorst AO, Pillai RN, Yang S, Nasti TH, Akondy RS, Wieland A, et al. Proliferation of PD-1\u2009+\u2009CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc Natl Acad Sci U S A. 2017;114(19):4993\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"8484_CR46","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/s41416-024-02583-0","volume":"130","author":"M Hashimoto","year":"2024","unstructured":"Hashimoto M, Kuroda S, Kanaya N, Kadowaki D, Yoshida Y, Sakamoto M, et al. Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus. Br J Cancer. 2024;130(7):1187\u201395.","journal-title":"Br J Cancer"},{"issue":"5","key":"8484_CR47","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","volume":"38","author":"F Dammeijer","year":"2020","unstructured":"Dammeijer F, van Gulijk M, Mulder EE, Lukkes M, Klaase L, van den Bosch T, et al. The PD-1\/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes. Cancer Cell. 2020;38(5):685\u2013700. e8.","journal-title":"Cancer Cell"},{"issue":"1","key":"8484_CR48","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","volume":"56","author":"N Prokhnevska","year":"2023","unstructured":"Prokhnevska N, Cardenas MA, Valanparambil RM, Sobierajska E, Barwick BG, Jansen C, et al. CD8(+) T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor. Immunity. 2023;56(1):107\u201324. e5.","journal-title":"Immunity"},{"key":"8484_CR49","doi-asserted-by":"crossref","unstructured":"Miyazaki I, Asanuma M. Multifunctional Metallothioneins as a Target for Neuroprotection in Parkinson\u2019s Disease. Antioxid (Basel). 2023;12(4).","DOI":"10.3390\/antiox12040894"},{"issue":"1","key":"8484_CR50","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s12011-017-1119-7","volume":"183","author":"AK Baltaci","year":"2018","unstructured":"Baltaci AK, Yuce K, Mogulkoc R. Zinc Metabolism and Metallothioneins. Biol Trace Elem Res. 2018;183(1):22\u201331.","journal-title":"Biol Trace Elem Res"},{"issue":"4\u20135","key":"8484_CR51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.mam.2005.07.012","volume":"26","author":"PI Oteiza","year":"2005","unstructured":"Oteiza PI, Mackenzie GG. Zinc, oxidant-triggered cell signaling, and human health. Mol Aspects Med. 2005;26(4\u20135):245\u201355.","journal-title":"Mol Aspects Med"},{"issue":"5","key":"8484_CR52","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.4049\/jimmunol.1600410","volume":"197","author":"MM George","year":"2016","unstructured":"George MM, Subramanian Vignesh K, Landero Figueroa JA, Caruso JA, Deepe GS. Jr. Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance. J Immunol. 2016;197(5):1864\u201376.","journal-title":"J Immunol"},{"key":"8484_CR53","doi-asserted-by":"crossref","unstructured":"Huang B, Liu R, Wang P, Yuan Z, Yang J, Xiong H et al. CD8(+)CD57(+) T cells exhibit distinct features in human non-small cell lung cancer. J Immunother Cancer. 2020;8(1).","DOI":"10.1136\/jitc-2020-000639"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08484-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08484-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08484-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T23:09:21Z","timestamp":1788736161000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08484-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8484"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08484-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Institutional Review Board and Ethics Committee of Tianjin Medical University Cancer Institute & Hospital (E20210014) and conformed to the Declaration of Helsinki and the Good Clinical Practice guidelines. Written informed consent was obtained from all participants. Animal experiments were approved by the Laboratory Animal Ethics Committee of Tianjin Medical University Cancer Institutes & Hospital (AE-2022040), and conducted following the Basel Declaration and institutional guidelines, with adherence to the International Council for Laboratory Animal Science (ICLAS) principles to ensure ethi cal standards.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided written informed consent and agreed to the publication of anonymized data. No individual patient-identifiable information is included in this manuscript.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1143"}}