{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:51Z","timestamp":1790171991054,"version":"4.1.0"},"reference-count":190,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203652"],"award-info":[{"award-number":["82203652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300717"],"award-info":[{"award-number":["82300717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the joint construction project of Henan Provincial Medical Science and Technology Research Program","award":["LHGJ20220285"],"award-info":[{"award-number":["LHGJ20220285"]}]},{"name":"the joint construction project of Henan Provincial Medical Science and Technology Research Program","award":["LHGJ20230374"],"award-info":[{"award-number":["LHGJ20230374"]}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["242102311175"],"award-info":[{"award-number":["242102311175"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Key R&D and Promotion Special (Scientific and technological research) Project","award":["242102311199"],"award-info":[{"award-number":["242102311199"]}]},{"name":"Clinical Medical Scientist Training Program under the \u201cThree 100\u201d Initiative of Henan Province","award":["HNCMS202420"],"award-info":[{"award-number":["HNCMS202420"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08547-7","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:06:38Z","timestamp":1783389998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiocrine factors in tumor microenvironment: bidirectional crosstalk, mechanistic insights, and therapeutic strategies"],"prefix":"10.1186","volume":"24","author":[{"given":"Gaili","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuchen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9067-8292","authenticated-orcid":false,"given":"Caixia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"8547_CR1","doi-asserted-by":"crossref","unstructured":"Chen F, Zhuang XQ, Lin LY, Yu PF, Wang Y, Shi YF, Hu GH, Sun Y. New horizons in tumor microenvironment biology: challenges and opportunities. Bmc Med. 2015;13:45.","DOI":"10.1186\/s12916-015-0278-7"},{"issue":"2","key":"8547_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nrc2791","volume":"10","author":"JM Butler","year":"2010","unstructured":"Butler JM, Kobayashi H, Rafii S. Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer. 2010;10(2):138\u201346.","journal-title":"Nat Rev Cancer"},{"issue":"7586","key":"8547_CR3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature17040","volume":"529","author":"S Rafii","year":"2016","unstructured":"Rafii S, Butler JM, Ding BS. Angiocrine functions of organ-specific endothelial cells. Nature. 2016;529(7586):316\u201325.","journal-title":"Nature"},{"issue":"3","key":"8547_CR4","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/path.4845","volume":"241","author":"VL Bridgeman","year":"2017","unstructured":"Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, Nathan MR, Wan E, Frentzas S, Schweiger T, et al. Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J Pathol. 2017;241(3):362\u201374.","journal-title":"J Pathol"},{"key":"8547_CR5","doi-asserted-by":"crossref","unstructured":"Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Tar. 2023;8(1):198.","DOI":"10.1038\/s41392-023-01460-1"},{"issue":"3","key":"8547_CR6","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ccr.2014.02.005","volume":"25","author":"ZW Cao","year":"2014","unstructured":"Cao ZW, Ding BS, Guo PP, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, et al. Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance. Cancer Cell. 2014;25(3):350\u201365.","journal-title":"Cancer Cell"},{"issue":"1","key":"8547_CR7","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ccell.2016.11.010","volume":"31","author":"ZW Cao","year":"2017","unstructured":"Cao ZW, Scandura JM, Inghirami GG, Shido K, Ding BS, Rafii S. Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells. Cancer Cell. 2017;31(1):110\u201326.","journal-title":"Cancer Cell"},{"key":"8547_CR8","doi-asserted-by":"crossref","unstructured":"Alsina-Sanchis E, M\u00fclfarth R, Fischer A. Control of tumor progression by angiocrine factors. Cancers. 2021;13(11):2610.","DOI":"10.3390\/cancers13112610"},{"key":"8547_CR9","doi-asserted-by":"crossref","unstructured":"Schaaf MB, Garg AD, Agostinis P. Defining the role of the tumor vasculature in antitumor immunity and immunotherapy. Cell Death Dis. 2018;9(2):115.","DOI":"10.1038\/s41419-017-0061-0"},{"key":"8547_CR10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-3-030-37184-5_6","volume":"1234","author":"K Sobierajska","year":"2020","unstructured":"Sobierajska K, Ciszewski WM, Sacewicz-Hofman I, Niewiarowska J. Endothelial Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1234:71\u201386.","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"8547_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10456-017-9552-y","volume":"20","author":"RR Ramjiawan","year":"2017","unstructured":"Ramjiawan RR, Griffioen AW, Duda DG. Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy? Angiogenesis. 2017;20(2):185\u2013204.","journal-title":"Angiogenesis"},{"key":"8547_CR12","doi-asserted-by":"crossref","unstructured":"Oria VO, Erler JT. Tumor Angiocrine signaling: novel targeting opportunity in cancer. Cells. 2023;12(20):2510.","DOI":"10.3390\/cells12202510"},{"issue":"13","key":"8547_CR13","doi-asserted-by":"publisher","first-page":"5957","DOI":"10.7150\/thno.45422","volume":"10","author":"SP Zhu","year":"2020","unstructured":"Zhu SP, Bennett S, Kuek V, Xiang C, Xu HZ, Rosen V, Xu JK. Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms. Theranostics. 2020;10(13):5957\u201365.","journal-title":"Theranostics"},{"issue":"6","key":"8547_CR14","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3748\/wjg.v10.i6.809","volume":"10","author":"GW Huang","year":"2004","unstructured":"Huang GW, Yang LY, Lu WQ. Effects of PI3K and p42\/p44 MAPK on overexpression of vascular endothelial growth factor in hepatocellular carcinoma. World J Gastroentero. 2004;10(6):809\u201312.","journal-title":"World J Gastroentero"},{"issue":"3","key":"8547_CR15","first-page":"289","volume":"312","author":"CE Semino","year":"2006","unstructured":"Semino CE, Kamm RD, Lauffenburger DA. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow. Exp Cell Res. 2006;312(3):289\u201398.","journal-title":"Exp Cell Res"},{"key":"8547_CR16","doi-asserted-by":"crossref","unstructured":"Nicolas S, Abdellatef S, Al Haddad M, Fakhoury I, El-Sibai M. Hypoxia and EGF Stimulation regulate VEGF expression in human glioblastoma multiforme (GBM) Cells by differential regulation of the PI3K\/Rho-GTPase and MAPK pathways. Cells. 2019;8(11):1397.","DOI":"10.3390\/cells8111397"},{"issue":"5901","key":"8547_CR17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1126\/science.1156232","volume":"322","author":"W Tang","year":"2008","unstructured":"Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322(5901):583\u20136.","journal-title":"Science"},{"key":"8547_CR18","doi-asserted-by":"crossref","unstructured":"Wang QR, He ZQ, Huang MG, Liu TR, Wang YL, Xu HN, Duan H, Ma PH, Zhang L, Zamvil SS, et al. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2\u03b1. Nat Commun. 2018;9(1):559.","DOI":"10.1038\/s41467-018-03050-0"},{"key":"8547_CR19","doi-asserted-by":"crossref","unstructured":"Lim JTC, Kwang LG, Ho NCW, Toh CCM, Too NSH, Hooi L, Benoukraf T, Chow PKH, Dan YY, Chow EKH, et al. Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment. Biomaterials. 2022;284:121527.","DOI":"10.1016\/j.biomaterials.2022.121527"},{"issue":"5","key":"8547_CR20","doi-asserted-by":"publisher","first-page":"C1195","DOI":"10.1152\/ajpcell.00546.2002","volume":"286","author":"PJ Kuhlencordt","year":"2004","unstructured":"Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, et al. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol-Cell Ph. 2004;286(5):C1195\u2013202.","journal-title":"Am J Physiol-Cell Ph"},{"key":"8547_CR21","doi-asserted-by":"crossref","unstructured":"Yang N, Li XX, Huang WW, Ji GL, Luo W, Jiang FM, et al. MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy. Nat Cell Biol. 2025;27(9):1526\u201342.","DOI":"10.1038\/s41556-025-01740-8"},{"issue":"4","key":"8547_CR22","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1182\/blood-2008-01-134429","volume":"112","author":"M Stefanidakis","year":"2008","unstructured":"Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW. Endothelial CD47 interaction with SIRP\u03b3 is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood. 2008;112(4):1280\u20139.","journal-title":"Blood"},{"issue":"1","key":"8547_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jhep.2023.02.032","volume":"79","author":"JZ Tan","year":"2023","unstructured":"Tan JZ, Fan WZ, Liu T, Zhu BW, Liu YF, Wang ST, Wu J, Liu J, Zou F, Wei JL, et al. TREM2\u2009+\u2009macrophages suppress CD8\u2009+\u2009T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma. J Hepatol. 2023;79(1):126\u201340.","journal-title":"J Hepatol"},{"issue":"12","key":"8547_CR24","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1084\/jem.20051759","volume":"203","author":"LA Johnson","year":"2006","unstructured":"Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203(12):2763\u201377.","journal-title":"J Exp Med"},{"issue":"3","key":"8547_CR25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1023\/B:CLIN.0000037696.36108.27","volume":"21","author":"AH Finzel","year":"2004","unstructured":"Finzel AH, Reininger AJ, Bode PA, Wurzinger LJ. ICAM-1 supports adhesion of human small-cell lung carcinoma to endothelial cells. Clin Exp Metastas. 2004;21(3):185\u20139.","journal-title":"Clin Exp Metastas"},{"issue":"2","key":"8547_CR26","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/jcp.21029","volume":"212","author":"M Klemke","year":"2007","unstructured":"Klemke M, Weschenfelder T, Konstandin MH, Samstag Y. High affinity interaction of integrin \u03b14\u03b21 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J Cell Physiol. 2007;212(2):368\u201374.","journal-title":"J Cell Physiol"},{"key":"8547_CR27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s12885-016-2366-2","volume":"16","author":"SA Kang","year":"2016","unstructured":"Kang SA, Blache CA, Bajana S, Hasan N, Kamal M, Morita Y, Gupta V, Tsolmon B, Suh KS, Gorenstein DG, et al. The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016;16:331.","journal-title":"BMC Cancer"},{"issue":"9","key":"8547_CR28","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1093\/glycob\/cwx105","volume":"28","author":"L Borsig","year":"2018","unstructured":"Borsig L. Selectins in cancer immunity. Glycobiology. 2018;28(9):648\u201355.","journal-title":"Glycobiology"},{"issue":"7321","key":"8547_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature09493","volume":"468","author":"BS Ding","year":"2010","unstructured":"Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature. 2010;468(7321):310\u2013U240.","journal-title":"Nature"},{"issue":"9","key":"8547_CR30","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S1359-6446(01)01752-4","volume":"6","author":"HD Foda","year":"2001","unstructured":"Foda HD, Zucker S. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today. 2001;6(9):478\u201382.","journal-title":"Drug Discov Today"},{"issue":"7","key":"8547_CR31","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/ncb2767","volume":"15","author":"CM Ghajar","year":"2013","unstructured":"Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, et al. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol. 2013;15(7):807\u201317.","journal-title":"Nat Cell Biol"},{"key":"8547_CR32","doi-asserted-by":"crossref","unstructured":"Ma J, Zhang LY, Zhang X, Zhang LL, Zhang H, Zhu YL, Huang XM, Zhang T, Tang XD, Wang Y, et al. Inhibiting endothelial blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration. Sci Transl Med. 2024;16(762):eado5266.","DOI":"10.1126\/scitranslmed.ado5266"},{"issue":"6","key":"8547_CR33","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","volume":"31","author":"J Zhang","year":"2020","unstructured":"Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni-Barrera R, Masschelein E, et al. Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization. Cell Metab. 2020;31(6):1136\u20131153.e7.","journal-title":"Cell Metab"},{"issue":"1","key":"8547_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.yexcr.2018.06.003","volume":"370","author":"X Wu","year":"2018","unstructured":"Wu X, Liu Z, Hu L, Gu W, Zhu L. Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126. Exp Cell Res. 2018;370(1):13\u201323.","journal-title":"Exp Cell Res"},{"key":"8547_CR35","doi-asserted-by":"crossref","unstructured":"Tao KY, Liu JS, Liang JX, Xu XF, Xu LW, Mao WM. Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2. Carcinogenesis. 2021;42(8):1056\u20131067.","DOI":"10.1093\/carcin\/bgab051"},{"issue":"12","key":"8547_CR36","doi-asserted-by":"publisher","first-page":"10253","DOI":"10.18632\/oncotarget.3520","volume":"6","author":"N Bovy","year":"2015","unstructured":"Bovy N, Blomme B, Freres P, Dederen S, Nivelles O, Lion M, Carnet O, Martial JA, Noel A, Thiry M, et al. Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer. Oncotarget. 2015;6(12):10253\u201366.","journal-title":"Oncotarget"},{"issue":"1","key":"8547_CR37","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1074\/jbc.M113.506899","volume":"289","author":"R Ju","year":"2014","unstructured":"Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M. Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)\/Akt\/endothelial nitric oxide synthase (eNOS) and syndecan-4\/syntenin pathways. J Biol Chem. 2014;289(1):510\u20139.","journal-title":"J Biol Chem"},{"issue":"2","key":"8547_CR38","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1096\/fj.201800428R","volume":"33","author":"ZH Xu","year":"2019","unstructured":"Xu ZH, Miao ZW, Jiang QZ, Gan DX, Wei XG, Xue XZ, Li JQ, Zheng F, Qin XX, Fang WG, et al. Brain microvascular endothelial cell exosome-mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain. Faseb J. 2019;33(2):1742\u201357.","journal-title":"Faseb J"},{"key":"8547_CR39","doi-asserted-by":"crossref","unstructured":"Pasquier J, Al Thawadi H, Abu Kaoud N, Ghiabi P, Maleki M, Guerrouahen BS, et al. Microparticles mediate cross-talk between tumoral and endothelial cells and promote the constitution of an angiocrine pro-metastatic niche through Arf6 up regulation. Clin Cancer Res. 2013;19:A74.","DOI":"10.1158\/1078-0432.OVCA13-A74"},{"key":"8547_CR40","doi-asserted-by":"crossref","unstructured":"Han Y, Gong WS, Xing XS, Zhou H, Wang XL, Xu Y, Zhou XL, Xue WL. miR-183-5p-enriched extracellular vesicles promote the crosstalk between hepatocellular carcinoma cell and endothelial cell via SIK1\/PI3K\/AKT and CCL20\/CCR6 signaling pathways. Front Oncol. 2025;15:1532239.","DOI":"10.3389\/fonc.2025.1532239"},{"issue":"4","key":"8547_CR41","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41593-020-00788-z","volume":"24","author":"I Paredes","year":"2021","unstructured":"Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, et al. Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021;24(4):478\u201388.","journal-title":"Nat Neurosci"},{"issue":"6","key":"8547_CR42","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/jnci\/djs009","volume":"104","author":"T Holopainen","year":"2012","unstructured":"Holopainen T, Saharinen P, D\u2019Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloter\u00e4 H, et al. Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis. J Natl Cancer I. 2012;104(6):461\u201375.","journal-title":"J Natl Cancer I"},{"issue":"2","key":"8547_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nm.4035","volume":"22","author":"ZW Cao","year":"2016","unstructured":"Cao ZW, Lis R, Ginsberg M, Chayez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S, Ding BS. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med. 2016;22(2):154\u201362.","journal-title":"Nat Med"},{"key":"8547_CR44","first-page":"323","volume":"281","author":"SK Ramasamy","year":"2014","unstructured":"Ramasamy SK, Kusumbe AP, Adams RH. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Febs J. 2014;281:323\u2013323.","journal-title":"Febs J"},{"issue":"2","key":"8547_CR45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/hep.29613","volume":"68","author":"T Leibing","year":"2018","unstructured":"Leibing T, G\u00e9raud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, et al. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2018;68(2):707\u201322.","journal-title":"Hepatology"},{"issue":"20","key":"8547_CR46","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1101\/gad.1589207","volume":"21","author":"C Roca","year":"2007","unstructured":"Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Gene Dev. 2007;21(20):2511\u201324.","journal-title":"Gene Dev"},{"issue":"3","key":"8547_CR47","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ccell.2017.01.007","volume":"31","author":"E Wieland","year":"2017","unstructured":"Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, et al. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. 2017;31(3):355\u201367.","journal-title":"Cancer Cell"},{"issue":"3","key":"8547_CR48","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ccr.2014.02.018","volume":"25","author":"P Ntziachristos","year":"2014","unstructured":"Ntziachristos P, Lim JS, Sage J, Aifantis I. From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling. Cancer Cell. 2014;25(3):318\u201334.","journal-title":"Cancer Cell"},{"issue":"29","key":"8547_CR49","doi-asserted-by":"publisher","first-page":"E3836","DOI":"10.1073\/pnas.1511814112","volume":"112","author":"M Boareto","year":"2015","unstructured":"Boareto M, Jolly MK, Ben-Jacob E, Onuchic JN. Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision. P Natl Acad Sci USA. 2015;112(29):E3836\u201344.","journal-title":"P Natl Acad Sci USA"},{"issue":"5","key":"8547_CR50","doi-asserted-by":"publisher","first-page":"C947","DOI":"10.1152\/ajpcell.00389.2001","volume":"282","author":"M Papetti","year":"2002","unstructured":"Papetti M, Herman IM. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol-Cell Ph. 2002;282(5):C947\u201370.","journal-title":"Am J Physiol-Cell Ph"},{"issue":"3","key":"8547_CR51","doi-asserted-by":"publisher","first-page":"R129","DOI":"10.1016\/j.cub.2004.01.023","volume":"14","author":"F Schweisguth","year":"2004","unstructured":"Schweisguth F. Regulation of notch signaling activity. Curr Biol. 2004;14(3):R129\u201338.","journal-title":"Curr Biol"},{"key":"8547_CR52","doi-asserted-by":"crossref","unstructured":"Trindade A, Duarte A. Notch signaling function in the angiocrine regulation of tumor development. Cells. 2020;9(11):2467.","DOI":"10.3390\/cells9112467"},{"issue":"2","key":"8547_CR53","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ccr.2010.12.022","volume":"19","author":"N Sethi","year":"2011","unstructured":"Sethi N, Dai XD, Winter CG, Kang YB. Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells. Cancer Cell. 2011;19(2):192\u2013205.","journal-title":"Cancer Cell"},{"key":"8547_CR54","doi-asserted-by":"crossref","unstructured":"Marchetto NM, Begum S, Wu T, O\u2019Besso V, Yarborough CC, Valero-Pacheco N, Beaulieu AM, Kitajewski JK, Shawber CJ, Douglas NC. Endothelial Jagged1 Antagonizes Dll4\/Notch signaling in decidual angiogenesis during early mouse pregnancy. Int J Mol Sci. 2020;21(18):6477.","DOI":"10.3390\/ijms21186477"},{"issue":"6","key":"8547_CR55","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1083\/jcb.200302047","volume":"161","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161(6):1163\u201377.","journal-title":"J Cell Biol"},{"key":"8547_CR56","doi-asserted-by":"crossref","unstructured":"Mendon\u00e7a L, Trindade A, Carvalho C, Correia J, Badenes M, Gigante J, et al. Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumour cells. Clin Exp Metastasis. 2019;36(4):365\u201380.","DOI":"10.1007\/s10585-019-09973-2"},{"key":"8547_CR57","doi-asserted-by":"crossref","unstructured":"Blanco R, Gerhardt H. VEGF and notch in tip and stalk cell selection. Csh Perspect Med. 2013;3(1):a006569.","DOI":"10.1101\/cshperspect.a006569"},{"key":"8547_CR58","doi-asserted-by":"crossref","unstructured":"Tiemeijer LA, Ristori T, Stassen OMJA, Ahlberg JJ, De Bijl JJJ, Chen CS, et al. Engineered patterns of notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting. Iscience. 2022;25(5):104306.","DOI":"10.1016\/j.isci.2022.104306"},{"issue":"5","key":"8547_CR59","doi-asserted-by":"publisher","first-page":"E402","DOI":"10.1073\/pnas.1416287112","volume":"112","author":"M Boareto","year":"2015","unstructured":"Boareto M, Jolly MK, Lu MY, Onuchic JN, Clementi C, Ben-Jacob E. Jagged-Delta asymmetry in Notch signaling can give rise to a Sender\/Receiver hybrid phenotype. P Natl Acad Sci USA. 2015;112(5):E402\u20139.","journal-title":"P Natl Acad Sci USA"},{"issue":"47","key":"8547_CR60","doi-asserted-by":"publisher","first-page":"23551","DOI":"10.1073\/pnas.1913373116","volume":"116","author":"TY Kang","year":"2019","unstructured":"Kang TY, Bocci F, Jolly MK, Levin H, Onuchic JN, Levchenko A. Pericytes enable effective angiogenesis in the presence of proinflammatory signals. P Natl Acad Sci USA. 2019;116(47):23551\u201361.","journal-title":"P Natl Acad Sci USA"},{"issue":"4","key":"8547_CR61","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00432-013-1534-x","volume":"140","author":"ZG Liu","year":"2014","unstructured":"Liu ZG, Fan FT, Wang AY, Zheng SZ, Lu Y. Dll4-Notch signaling in regulation of tumor angiogenesis. J Cancer Res Clin. 2014;140(4):525\u201336.","journal-title":"J Cancer Res Clin"},{"issue":"11","key":"8547_CR62","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1182\/blood-2006-12-063933","volume":"109","author":"JS Scehnet","year":"2007","unstructured":"Scehnet JS, Jiang WD, Kumar SR, Krasnoperov V, Trindade A, Benedito R, Djokovic D, Borges C, Ley EJ, Duarte A, et al. Inhibition of D114-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood. 2007;109(11):4753\u201360.","journal-title":"Blood"},{"issue":"1","key":"8547_CR63","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.canlet.2015.12.025","volume":"372","author":"ZB Xu","year":"2016","unstructured":"Xu ZB, Wang ZG, Jia XL, Wang LX, Chen ZG, Wang SJ, Wang M, Zhang J, Wu M. MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth. Cancer Lett. 2016;372(1):118\u201327.","journal-title":"Cancer Lett"},{"key":"8547_CR64","doi-asserted-by":"crossref","unstructured":"Jiang HM, Zhou C, Zhang Z, Wang Q, Wei HM, Shi W, et al. Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1. Nat Commun. 2020;11(1):5129.","DOI":"10.1038\/s41467-020-18860-4"},{"issue":"3","key":"8547_CR65","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1158\/0008-5472.CAN-18-1752","volume":"79","author":"SA Wohlfeil","year":"2019","unstructured":"Wohlfeil SA, H\u00e4fele V, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, et al. Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling. Cancer Res. 2019;79(3):598\u2013610.","journal-title":"Cancer Res"},{"key":"8547_CR66","doi-asserted-by":"crossref","unstructured":"Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27.","DOI":"10.1186\/s12967-015-0386-3"},{"issue":"4","key":"8547_CR67","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4318\/tjg.2010.0122","volume":"21","author":"FH Dilek","year":"2010","unstructured":"Dilek FH, Topak N, Tokyol \u00c7, Akbulut G, Dilek ON. \u03b2-Catenin and its relation to VEGF and cyclin D1 expression in pT3 rectosigmoid cancers. Turk J Gastroenterol. 2010;21(4):365\u201371.","journal-title":"Turk J Gastroenterol"},{"issue":"24","key":"8547_CR68","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.1158\/1078-0432.CCR-09-0336","volume":"15","author":"S Naik","year":"2009","unstructured":"Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant \u03b2-Catenin Activation in Colon Cancer. Clin Cancer Res. 2009;15(24):7529\u201337.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"8547_CR69","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/his.12474","volume":"67","author":"ZY Liu","year":"2015","unstructured":"Liu ZY, Sun BC, Qi LS, Li YX, Zhao XL, Zhang DF, Zhang YH. Dickkopf-1 expression is down-regulated during the colorectal adenoma-carcinoma sequence and correlates with reduced microvessel density and VEGF expression. Histopathology. 2015;67(2):158\u201366.","journal-title":"Histopathology"},{"issue":"24","key":"8547_CR70","doi-asserted-by":"publisher","first-page":"7453","DOI":"10.1158\/1078-0432.CCR-09-2578","volume":"15","author":"BD Zeitlin","year":"2009","unstructured":"Zeitlin BD, Ellis LM, N\u00f6r JE. Inhibition of Vascular Endothelial Growth Factor Receptor-1\/Wnt\/\u03b2-catenin Crosstalk Leads to Tumor Cell Death. Clin Cancer Res. 2009;15(24):7453\u20135.","journal-title":"Clin Cancer Res"},{"key":"8547_CR71","doi-asserted-by":"crossref","unstructured":"Stepniak E, Radice GL, Vasioukhin V. Adhesive and signaling functions of cadherins and catenins in vertebrate development. Csh Perspect Biol. 2009;1(5):a002949.","DOI":"10.1101\/cshperspect.a002949"},{"issue":"1","key":"8547_CR72","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.devcel.2014.11.016","volume":"32","author":"GM Birdsey","year":"2015","unstructured":"Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang YW, Aspalter IM, Khan ST, Mason JC, Dejana E, et al. The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt\/\u03b2-Catenin Signaling. Dev Cell. 2015;32(1):82\u201396.","journal-title":"Dev Cell"},{"issue":"3","key":"8547_CR73","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.cell.2006.04.009","volume":"125","author":"K Bartscherer","year":"2006","unstructured":"Bartscherer K, Pelte N, Ingelfinger D, Boutros M. Secretion of Wnt Ligands requires Evi, a conserved transmembrane protein. Cell. 2006;125(3):523\u201333.","journal-title":"Cell"},{"issue":"8","key":"8547_CR74","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1242\/dev.104422","volume":"141","author":"C Korn","year":"2014","unstructured":"Korn C, Scholz B, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I. Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development. 2014;141(8):1757\u201366.","journal-title":"Development"},{"issue":"3","key":"8547_CR75","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1349-7006.2010.01815.x","volume":"102","author":"M Kamino","year":"2011","unstructured":"Kamino M, Kishida M, Kibe T, Ikoma K, Iijima M, Hirano H, Tokudome M, Chen L, Koriyama C, Yamada K, et al. Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2. Cancer Sci. 2011;102(3):540\u20138.","journal-title":"Cancer Sci"},{"issue":"1","key":"8547_CR76","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10555-020-09941-3","volume":"40","author":"K van Loon","year":"2021","unstructured":"van Loon K, Huijbers EJM, Griffioen AW. Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis. Cancer Metast Rev. 2021;40(1):191\u2013203.","journal-title":"Cancer Metast Rev"},{"key":"8547_CR77","doi-asserted-by":"crossref","unstructured":"Hayashi Y, Hashimoto M, Takaoka K, Takemoto T, Takakura N, Kidoya H. Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling. Vitro Cell Dev Biol Anim. 2024;60(10):1123\u201331.","DOI":"10.1007\/s11626-024-00899-y"},{"issue":"2","key":"8547_CR78","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/leu.2016.232","volume":"31","author":"F Linke","year":"2017","unstructured":"Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, et al. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. 2017;31(2):361\u201372.","journal-title":"Leukemia"},{"issue":"1","key":"8547_CR79","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.devcel.2008.12.009","volume":"16","author":"LK Phng","year":"2009","unstructured":"Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr JK, Rao S, Lang RA, Thurston G, et al. Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis. Dev Cell. 2009;16(1):70\u201382.","journal-title":"Dev Cell"},{"issue":"6","key":"8547_CR80","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.devcel.2010.05.006","volume":"18","author":"M Corada","year":"2010","unstructured":"Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E. The Wnt\/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4\/Notch signaling. Dev Cell. 2010;18(6):938\u201349.","journal-title":"Dev Cell"},{"issue":"12","key":"8547_CR81","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1161\/ATVBAHA.116.307926","volume":"36","author":"C Peghaire","year":"2016","unstructured":"Peghaire C, Bats ML, Sewduth R, Jeanningros S, Jaspard B, Couffinhal T, Dupl\u00e0a C, Dufourcq P. Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt\/\u03b2-Catenin Canonical Signaling. Arterioscl Throm Vas. 2016;36(12):2369\u201380.","journal-title":"Arterioscl Throm Vas"},{"key":"8547_CR82","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.canlet.2020.10.012","volume":"498","author":"JI Choi","year":"2021","unstructured":"Choi JI, Jang SI, Hong J, Kim CH, Kwon SS, Park JS, Lim JB. Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells. Cancer Lett. 2021;498:42\u201353.","journal-title":"Cancer Lett"},{"key":"8547_CR83","doi-asserted-by":"crossref","unstructured":"Alve S, Gramolelli S, Jukonen J, Juteau S, Pink A, Manninen AA, H\u00e4nninen S, Monto E, Lackman MH, Carp\u00e9n O et al. DLL4\/Notch3\/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells. Jci Insight. 2024;9(1):e171821.","DOI":"10.1172\/jci.insight.171821"},{"issue":"3","key":"8547_CR84","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00210-020-01988-x","volume":"394","author":"F Nasser","year":"2021","unstructured":"Nasser F, Moussa N, Helmy MW, Haroun M. Dual targeting of Notch and Wnt\/\u03b2-catenin pathways: Potential approach in triple-negative breast cancer treatment. N-S Arch Pharmacol. 2021;394(3):481\u201390.","journal-title":"N-S Arch Pharmacol"},{"issue":"1","key":"8547_CR85","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00424-012-1085-z","volume":"464","author":"LN Groschner","year":"2012","unstructured":"Groschner LN, Waldeck-Weiermair M, Malli R, Graier WF. Endothelial mitochondria-less respiration, more integration. Pflug Arch Eur J Phy. 2012;464(1):63\u201376.","journal-title":"Pflug Arch Eur J Phy"},{"issue":"3","key":"8547_CR86","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesqui\u00e8re B, Cauwenberghs S, Eelen G, et al. Role of PFKFB3-Driven Glycolysis in Vessel Sprouting. Cell. 2013;154(3):651\u201363.","journal-title":"Cell"},{"issue":"5","key":"8547_CR87","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.cmet.2013.08.001","volume":"18","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Carmeliet P. Role of Endothelial Cell Metabolism in Vessel Sprouting. Cell Metab. 2013;18(5):634\u201347.","journal-title":"Cell Metab"},{"issue":"1","key":"8547_CR88","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1152\/physrev.00001.2017","volume":"98","author":"G Eelen","year":"2018","unstructured":"Eelen G, de Zeeuw P, Treps L, Harjes U, Wong BW, Carmeliet P. Endothelial Cell Metabolism. Physiol Rev. 2018;98(1):3\u201358.","journal-title":"Physiol Rev"},{"issue":"1","key":"8547_CR89","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1124\/mol.107.038851","volume":"73","author":"WL Yeh","year":"2008","unstructured":"Yeh WL, Lin CJ, Fu WM. Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia. Mol Pharmacol. 2008;73(1):170\u20137.","journal-title":"Mol Pharmacol"},{"key":"8547_CR90","doi-asserted-by":"crossref","unstructured":"Du W, Ren L, Hamblin MH, Fan YB. Endothelial cell glucose metabolism and angiogenesis. Biomedicines. 2021;9(2):147.","DOI":"10.3390\/biomedicines9020147"},{"key":"8547_CR91","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Caballero M, Sokol L, Cuypers A, Carmeliet P. Metabolic reprogramming in tumor endothelial cells. Int J Mol Sci. 2022;23(19):11052.","DOI":"10.3390\/ijms231911052"},{"issue":"4","key":"8547_CR92","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10456-017-9573-6","volume":"20","author":"LC Conradi","year":"2017","unstructured":"Conradi LC, Brajic A, Cantelmo AR, Bouche A, Kalucka J, Pircher A, Br\u00fcning U, Teuwen LA, Vinckier S, Ghesqui\u00e8re B, et al. Tumor vessel disintegration by maximum tolerable PFKFB3 blockade. Angiogenesis. 2017;20(4):599\u2013613.","journal-title":"Angiogenesis"},{"issue":"2","key":"8547_CR93","first-page":"2937","volume":"17","author":"LH Zhang","year":"2018","unstructured":"Zhang LH, Li SF, Li L, Chen ZQ, Yang Y. COX-2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression. Mol Med Rep. 2018;17(2):2937\u201344.","journal-title":"Mol Med Rep"},{"issue":"11","key":"8547_CR94","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1038\/s41590-020-0764-8","volume":"21","author":"BS Zhou","year":"2020","unstructured":"Zhou BS, Magana L, Hong ZG, Huang LS, Chakraborty S, Tsukasaki Y, et al. The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury. Nat Immunol. 2020;21(11):1430\u201343.","journal-title":"Nat Immunol"},{"issue":"29","key":"8547_CR95","doi-asserted-by":"publisher","first-page":"21161","DOI":"10.1074\/jbc.M113.474619","volume":"288","author":"GX Ruan","year":"2013","unstructured":"Ruan GX, Kazlauskas A. Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase\/Akt and Promote Angiogenesis. J Biol Chem. 2013;288(29):21161\u201372.","journal-title":"J Biol Chem"},{"issue":"7","key":"8547_CR96","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","volume":"71","author":"F V\u00e9gran","year":"2011","unstructured":"V\u00e9gran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-\u03baB\/IL-8 Pathway that Drives Tumor Angiogenesis. Cancer Res. 2011;71(7):2550\u201360.","journal-title":"Cancer Res"},{"issue":"6","key":"8547_CR97","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1161\/ATVBAHA.113.303041","volume":"34","author":"YM Xu","year":"2014","unstructured":"Xu YM, An XF, Guo X, Habtetsion TG, Wang Y, Xu XZ, Kandala S, Li QK, Li HG, Zhang CX, et al. Endothelial PFKFB3 Plays a Critical Role in Angiogenesis. Arterioscl Throm Vas. 2014;34(6):1231\u20139.","journal-title":"Arterioscl Throm Vas"},{"key":"8547_CR98","doi-asserted-by":"crossref","unstructured":"Chen J, Huang ZY, Chen Y, Tian H, Chai PW, Shen YN, et al. Lactate and lactylation in cancer. Signal Transduct Tar. 2025;10(1):38.","DOI":"10.1038\/s41392-024-02082-x"},{"issue":"4","key":"8547_CR99","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.apsb.2022.02.014","volume":"12","author":"YL Shan","year":"2022","unstructured":"Shan YL, Ni Q, Zhang QX, Zhang MY, Wei B, Cheng LG, Zhong CJ, Wang XY, Wang QQ, Liu JL, et al. Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment. Acta Pharm Sin B. 2022;12(4):1825\u201339.","journal-title":"Acta Pharm Sin B"},{"issue":"6","key":"8547_CR100","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ccell.2016.10.006","volume":"30","author":"AR Cantelmo","year":"2016","unstructured":"Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, et al. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. Cancer Cell. 2016;30(6):968\u201385.","journal-title":"Cancer Cell"},{"issue":"4","key":"8547_CR101","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrc3910","volume":"15","author":"CM Ghajar","year":"2015","unstructured":"Ghajar CM. Metastasis prevention by targeting the dormant niche. Nat Rev Cancer. 2015;15(4):238\u201347.","journal-title":"Nat Rev Cancer"},{"key":"8547_CR102","doi-asserted-by":"crossref","unstructured":"Jakab M, Lee KH, Uvarovskii A, Ovchinnikova S, Kulkarni SR, Jakab S, et al. Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency. Nat Cancer. 2024;5(5):716\u201330.","DOI":"10.1038\/s43018-023-00716-7"},{"issue":"8","key":"8547_CR103","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/nm1444","volume":"12","author":"S Bandyopadhyay","year":"2006","unstructured":"Bandyopadhyay S, Zhan R, Chaudhuri A, Watabe M, Pai SK, Hirota S, Hosobe S, Tsukada T, Miura K, Takano Y, et al. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med. 2006;12(8):933\u20138.","journal-title":"Nat Med"},{"issue":"4","key":"8547_CR104","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.trecan.2024.03.001","volume":"10","author":"R Tomasin","year":"2024","unstructured":"Tomasin R, Ghajar CM. Poised epigenetic states dictate metastatic fitness. Trends Cancer. 2024;10(4):275\u20136.","journal-title":"Trends Cancer"},{"issue":"10","key":"8547_CR105","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ncb2103","volume":"12","author":"L Jakobsson","year":"2010","unstructured":"Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol. 2010;12(10):943\u201353.","journal-title":"Nat Cell Biol"},{"issue":"4","key":"8547_CR106","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1158\/0008-5472.CAN-19-3351","volume":"80","author":"M Singhal","year":"2020","unstructured":"Singhal M, Augustin HG. Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis. Cancer Res. 2020;80(4):659\u201362.","journal-title":"Cancer Res"},{"issue":"7615","key":"8547_CR107","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nature19076","volume":"536","author":"B Strilic","year":"2016","unstructured":"Strilic B, Yang LD, Albarr\u00e1n-Ju\u00e1rez J, Wachsmuth L, Han K, M\u00fcller UC, Pasparakis M, Offermanns S. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536(7615):215\u20138.","journal-title":"Nature"},{"key":"8547_CR108","doi-asserted-by":"crossref","unstructured":"Chen XP, Cheng B, Dai DF, Wu YH, Feng ZW, Tong CG, Wang XM, Zhao J. Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma. Cell Death Discov. 2021;7(1):33.","DOI":"10.1038\/s41420-021-00411-5"},{"key":"8547_CR109","doi-asserted-by":"crossref","unstructured":"Bolik J, Krause F, Stevanovic M, Gandrass M, Thomsen I, Schacht SS, Rieser E, Mueller M, Schumacher N, Fritsch J et al. Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. J Exp Med. 2021;219(1):e20201039.","DOI":"10.1084\/jem.20201039"},{"issue":"11","key":"8547_CR110","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41423-024-01217-y","volume":"21","author":"XX Wu","year":"2024","unstructured":"Wu XX, Zhao XM, Li F, Wang Y, Ou YJ, Zhang HW, Li XM, Wu XH, Wang LX, Li M, et al. MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. Cell Mol Immunol. 2024;21(11):1309\u201321.","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"8547_CR111","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.cell.2010.07.044","volume":"142","author":"MP Chao","year":"2010","unstructured":"Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, et al. Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma. Cell. 2010;142(5):699\u2013713.","journal-title":"Cell"},{"issue":"4","key":"8547_CR112","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ccr.2012.02.017","volume":"21","author":"ES Nakasone","year":"2012","unstructured":"Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, et al. Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance. Cancer Cell. 2012;21(4):488\u2013503.","journal-title":"Cancer Cell"},{"issue":"8","key":"8547_CR113","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41568-021-00366-w","volume":"21","author":"D Bayik","year":"2021","unstructured":"Bayik D, Lathia JD. Cancer stem cell-immune cell crosstalk in tumour progression. Nat Rev Cancer. 2021;21(8):526\u201336.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"8547_CR114","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s11684-023-1049-z","volume":"18","author":"Y Ma","year":"2024","unstructured":"Ma Y, Lv HW, Xing FX, Xiang W, Wu ZX, Feng QY, Wang HY, Yang W. Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression. Front Med-Prc. 2024;18(3):430\u201345.","journal-title":"Front Med-Prc"},{"issue":"4","key":"8547_CR115","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.bbrc.2017.02.076","volume":"496","author":"JK Kim","year":"2018","unstructured":"Kim JK, Jeon HM, Jeon HY, Oh SY, Kim EJ, Jin X, Kim SH, Kim SH, Jin X, Kim H. Conversion of glioma cells to glioma stem-like cells by angiocrine factors. Biochem Bioph Res Co. 2018;496(4):1013\u20138.","journal-title":"Biochem Bioph Res Co"},{"issue":"8","key":"8547_CR116","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/1878-0261.12071","volume":"11","author":"R Wang","year":"2017","unstructured":"Wang R, Bhattacharya R, Ye XC, Fan F, Boulbes DR, Xia L, Ellis LM. Endothelial cells activate the cancer stem cell-associated 8 pathway in colorectal cancer cells in a paracrine fashion. Mol Oncol. 2017;11(8):1023\u201334.","journal-title":"Mol Oncol"},{"issue":"2","key":"8547_CR117","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ccr.2012.12.021","volume":"23","author":"J Lu","year":"2013","unstructured":"Lu J, Ye XC, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou YF, Tachibana I, et al. Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1. Cancer Cell. 2013;23(2):171\u201385.","journal-title":"Cancer Cell"},{"key":"8547_CR118","doi-asserted-by":"crossref","unstructured":"Fessler E, Borovski T, Medema JP. Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF. Mol Cancer. 2015;14:157.","DOI":"10.1186\/s12943-015-0420-3"},{"issue":"6","key":"8547_CR119","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.ccell.2015.10.003","volume":"28","author":"Y Hayakawa","year":"2015","unstructured":"Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang HS, Westphalen CB, et al. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015;28(6):800\u201314.","journal-title":"Cancer Cell"},{"issue":"7369","key":"8547_CR120","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nature10525","volume":"478","author":"B Beck","year":"2011","unstructured":"Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, Caauwe A, Sotiropoulou PA, Loges S, Lapouge G, Candi A, et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature. 2011;478(7369):399\u2013403.","journal-title":"Nature"},{"key":"8547_CR121","doi-asserted-by":"crossref","unstructured":"Wu ZG, Guo S, Yue HX, Huang H, Zhang ZR, Chen XX, Lan CY, Ren L, Hei P, Wang XY, et al. Effect of M2-macrophage treated lymphatic endothelial cells on angiogenesis that promoted osteointegration. Exp Cell Res. 2024;439(1):114096.","DOI":"10.1016\/j.yexcr.2024.114096"},{"key":"8547_CR122","doi-asserted-by":"crossref","unstructured":"Krejbich M, Navarro E, Fresquet J, Cotinat M, Isen V, Perdrieau H, Forest V, Dom\u00e9n\u00e9 A, Delaunay T, Awada H, et al. In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma. J Exp Clin Canc Res. 2025;45(1):15.","DOI":"10.1186\/s13046-025-03576-4"},{"issue":"23","key":"8547_CR123","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1158\/0008-5472.CAN-22-0076","volume":"82","author":"E Alsina-Sanchis","year":"2022","unstructured":"Alsina-Sanchis E, M\u00fclfarth R, Moll I, B\u00f6hn S, Wiedmann L, Jordana-Urriza L, Ziegelbauer T, Zimmer E, Taylor J, Rigotti FD, et al. Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages. Cancer Res. 2022;82(23):4414\u201328.","journal-title":"Cancer Res"},{"issue":"10","key":"8547_CR124","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1084\/jem.20101956","volume":"208","author":"B Molon","year":"2011","unstructured":"Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, De Palma A, Mauri P, Monegal A, Rescigno M, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med. 2011;208(10):1949\u201362.","journal-title":"J Exp Med"},{"issue":"6","key":"8547_CR125","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/nm.3541","volume":"20","author":"GT Motz","year":"2014","unstructured":"Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, Lal P, Feldman MD, Benencia F, Coukos G. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat Med. 2014;20(6):607\u201315.","journal-title":"Nat Med"},{"issue":"15","key":"8547_CR126","doi-asserted-by":"publisher","first-page":"6171","DOI":"10.1158\/0008-5472.CAN-10-0153","volume":"70","author":"RK Shrimali","year":"2010","unstructured":"Shrimali RK, Yu ZY, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer. Cancer Res. 2010;70(15):6171\u201380.","journal-title":"Cancer Res"},{"key":"8547_CR127","doi-asserted-by":"crossref","unstructured":"Opzoomer JW, Anstee JE, Dean I, Hill EJ, Bouybayoune I, Caron J, Muliaditan T, Gordon P, Sosnowska D, Nuamah R, et al. Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression. Sci Adv. 2021;7(45):eabg9518.","DOI":"10.1126\/sciadv.abg9518"},{"issue":"4","key":"8547_CR128","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.it.2015.02.005","volume":"36","author":"LB Rivera","year":"2015","unstructured":"Rivera LB, Bergers G. Intertwined regulation of angiogenesis and immunity by myeloid cells. Trends Immunol. 2015;36(4):240\u20139.","journal-title":"Trends Immunol"},{"key":"8547_CR129","doi-asserted-by":"crossref","unstructured":"Xu YX, Miller CP, Tykodi SS, Akilesh S, Warren EH. Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors. Front Cell Dev Biol. 2024;12:1387198.","DOI":"10.3389\/fcell.2024.1387198"},{"issue":"11","key":"8547_CR130","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/ncponc0342","volume":"2","author":"G Gasparini","year":"2005","unstructured":"Gasparini G, Longo R, Toi M, Ferrara N. Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat Clin Pract Oncol. 2005;2(11):562\u201377.","journal-title":"Nat Clin Pract Oncol"},{"issue":"2","key":"8547_CR131","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.canlet.2012.03.008","volume":"320","author":"F Shojaei","year":"2012","unstructured":"Shojaei F. Anti-angiogenesis therapy in cancer: Current challenges and future perspectives. Cancer Lett. 2012;320(2):130\u20137.","journal-title":"Cancer Lett"},{"issue":"9","key":"8547_CR132","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","volume":"77","author":"R Lugano","year":"2020","unstructured":"Lugano R, Ramachandran M, Dimberg A. Tumor angiogenesis: causes, consequences, challenges and opportunities. Cell Mol Life Sci. 2020;77(9):1745\u201370.","journal-title":"Cell Mol Life Sci"},{"key":"8547_CR133","doi-asserted-by":"crossref","unstructured":"Liu XR, Zhang J, Yi T, Li H, Tang X, Liu D, Wu DC, Li YK. Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies. Biomark Res. 2025;13(1):62.","DOI":"10.1186\/s40364-025-00779-x"},{"key":"8547_CR134","doi-asserted-by":"crossref","unstructured":"Itatani Y, Kawada K, Yamamoto T, Sakai Y. Resistance to anti-angiogenic therapy in cancer-alterations to anti-VEGF pathway. Int J Mol Sci. 2018;19(4):1232.","DOI":"10.3390\/ijms19041232"},{"key":"8547_CR135","doi-asserted-by":"crossref","unstructured":"Kim S, Han HJ, Han J, Choi Y, Ryoo IJ, Sivaraman A, et al. MO-2097 inhibits EMT and angiogenesis in colorectal cancer by targeting RAF\/MEK\/ERK signaling. Sci Rep-Uk. 2025;15(1):21781.","DOI":"10.1038\/s41598-025-05203-w"},{"issue":"3","key":"8547_CR136","doi-asserted-by":"publisher","first-page":"192","DOI":"10.18632\/aging.100296","volume":"3","author":"LS Steelman","year":"2011","unstructured":"Steelman LS, Chappell WH, Abrams SL, Kempf CR, Long J, Laidler P, Mijatovic S, Maksimovic-Ivanic D, Stivala F, Mazzarino MC, et al. Roles of the Raf\/MEK\/ERK and PI3K\/PTEN\/Akt\/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging-Us. 2011;3(3):192\u2013222.","journal-title":"Aging-Us"},{"key":"8547_CR137","doi-asserted-by":"crossref","unstructured":"He MY, Halford MM, Liu RF, Roy JP, Grant ZL, Coultas L, Thio N, Gilan O, Chan YC, Dawson MA, et al. Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy. Commun Biol. 2021;4(1):878.","DOI":"10.1038\/s42003-021-02397-3"},{"key":"8547_CR138","doi-asserted-by":"publisher","first-page":"S417","DOI":"10.1016\/S0168-8278(15)30508-0","volume":"62","author":"J Zhou","year":"2015","unstructured":"Zhou J, Chen R, Deng X. Knockdown of Nanog Reverses the Chemoresistance to Doxorubicin in Liver Cancer Stem-Like Cells by Reducing Abcb1 and Abcg2 Expression. J Hepatol. 2015;62:S417\u20138.","journal-title":"J Hepatol"},{"key":"8547_CR139","doi-asserted-by":"crossref","unstructured":"Zhu HZ, Tian YY, Chen HY, Qian YY, Li JH, Niu D, Zhao WY, Wu YL, Zhang X, Tang T, et al. Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions. Drug Resist Upd. 2025;83:101287.","DOI":"10.1016\/j.drup.2025.101287"},{"key":"8547_CR140","doi-asserted-by":"crossref","unstructured":"Lee SG, Kim J, Jeong E, Myung K. DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies. DNA Repair. 2025;153:103887.","DOI":"10.1016\/j.dnarep.2025.103887"},{"issue":"11","key":"8547_CR141","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1172\/JCI86623","volume":"126","author":"AK Shenoy","year":"2016","unstructured":"Shenoy AK, Jin Y, Luo HC, Tang M, Pampo C, Shao R, Siemann DW, Wu LZ, Heldermon CD, Law BK, et al. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J Clin Invest. 2016;126(11):4174\u201386.","journal-title":"J Clin Invest"},{"key":"8547_CR142","doi-asserted-by":"crossref","unstructured":"Yan TT, Shi JH. Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy. Front Immunol. 2024;15:1509195.","DOI":"10.3389\/fimmu.2024.1509195"},{"issue":"7","key":"8547_CR143","first-page":"865","volume":"15","author":"XG Mao","year":"2013","unstructured":"Mao XG, Xue XY, Wang L, Zhang X, Yan M, Tu YY, Lin W, Jiang XF, Ren HG, Zhang W, et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neurooncology. 2013;15(7):865\u201379.","journal-title":"Neurooncology"},{"issue":"8","key":"8547_CR144","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1158\/0008-5472.CAN-14-1855","volume":"75","author":"CI Schnegg","year":"2015","unstructured":"Schnegg CI, Yang MH, Ghosh SK, Hsu MY. Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma. Cancer Res. 2015;75(8):1682\u201390.","journal-title":"Cancer Res"},{"issue":"10","key":"8547_CR145","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.7150\/jca.24619","volume":"9","author":"XL Ma","year":"2018","unstructured":"Ma XL, Zhu KP, Zhang CL. Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma. J Cancer. 2018;9(10):1856\u201362.","journal-title":"J Cancer"},{"key":"8547_CR146","doi-asserted-by":"crossref","unstructured":"Wang ML, Zhao XL, Zhu DW, Liu TJ, Liang XH, Liu F, Zhang YH, Dong XY, Sun BC. HIF-1\u03b1 promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment. J Exp Clin Canc Res. 2017;36(1):60.","DOI":"10.1186\/s13046-017-0533-1"},{"key":"8547_CR147","doi-asserted-by":"crossref","unstructured":"Camorani S, Crescenzi E, Gramanzini M, Fedele M, Zannetti A, Cerchia L. Aptamer-mediated impairment of EGFR-integrin \u03b1v\u03b23 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers. Sci Rep. 2017;7:46659.","DOI":"10.1038\/srep46659"},{"key":"8547_CR148","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.canlet.2017.02.035","volume":"395","author":"Y Li","year":"2017","unstructured":"Li Y, Wu ZZ, Yuan J, Sun L, Lin L, Huang N, Bin JP, Liao YL, Liao WJ. Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis. Cancer Lett. 2017;395:31\u201344.","journal-title":"Cancer Lett"},{"key":"8547_CR149","doi-asserted-by":"crossref","unstructured":"Cannell IG, Sawicka K, Pearsall I, Wild SA, Deighton L, Pearsall SM, Lerda G, Joud F, Khan S, Bruna A, et al. FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapy. Cell Rep. 2023;42(8):112791.","DOI":"10.1016\/j.celrep.2023.112791"},{"key":"8547_CR150","doi-asserted-by":"crossref","unstructured":"Wang W, Lin P, Sun BC, Zhang SW, Cai WJ, Han CR, Li L, Lu HH, Zhao XL. Epithelial-Mesenchymal transition regulated by EphA2 contributes to vasculogenic mimicry formation of head and neck squamous cell carcinoma. Biomed Res Int. 2014;2014:803914.","DOI":"10.1155\/2014\/803914"},{"issue":"11","key":"8547_CR151","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/nm.4197","volume":"22","author":"S Frentzas","year":"2016","unstructured":"Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Nathan MR, Wotherspoon A, Gao ZH, Shi Y, et al. Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases. Nat Med. 2016;22(11):1294\u2013302.","journal-title":"Nat Med"},{"issue":"1","key":"8547_CR152","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10456-019-09698-6","volume":"23","author":"EA Kuczynski","year":"2020","unstructured":"Kuczynski EA, Reynolds AR. Vessel co-option and resistance to anti-angiogenic therapy. Angiogenesis. 2020;23(1):55\u201374.","journal-title":"Angiogenesis"},{"key":"8547_CR153","doi-asserted-by":"crossref","unstructured":"Carrera-Aguado I, Marcos-Zazo L, Carrancio-Sal\u00e1n P, Guerra-Paes E, S\u00e1nchez-Juanes F, Mu\u00f1oz-F\u00e9lix JM. The inhibition of vessel co-option as an emerging strategy for cancer therapy. Int J Mol Sci. 2024;25(2):921.","DOI":"10.3390\/ijms25020921"},{"issue":"7716","key":"8547_CR154","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41586-018-0342-5","volume":"560","author":"H Yao","year":"2018","unstructured":"Yao H, Price TT, Cantelli G, Ngo B, Warner MJ, Olivere L, Ridge SM, Jablonski EM, Therrien J, Tannheimer S, et al. Leukaemia hijacks a neural mechanism to invade the central nervous system. Nature. 2018;560(7716):55\u201360.","journal-title":"Nature"},{"issue":"3","key":"8547_CR155","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/carcin\/bgv006","volume":"36","author":"S Toden","year":"2015","unstructured":"Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland CR, Goel A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 2015;36(3):355\u201367.","journal-title":"Carcinogenesis"},{"key":"8547_CR156","doi-asserted-by":"crossref","unstructured":"Wen Q, Huang MH, Xie JW, Liu RY, Miao Q, Huang JJ, Zhang JQ, Lyu W, Qi M, Wu CY, et al. lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2. Drug Resist Update. 2023;69:100975.","DOI":"10.1016\/j.drup.2023.100975"},{"key":"8547_CR157","doi-asserted-by":"crossref","unstructured":"Qin S, Li AP, Yi M, Yu SN, Zhang MS, Wu KM. Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy. J Hematol Oncol. 2019;12(1):27.","DOI":"10.1186\/s13045-019-0718-5"},{"key":"8547_CR158","doi-asserted-by":"crossref","unstructured":"Yi M, Jiao DC, Qin S, Chu Q, Wu KM, Li AP. Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment. Mol Cancer. 2019; 18(1):60.","DOI":"10.1186\/s12943-019-0974-6"},{"key":"8547_CR159","doi-asserted-by":"crossref","unstructured":"Ren SJ, Xiong XX, You H, Shen JF, Zhou PH. The combination of immune checkpoint blockade and angiogenesis inhibitors in the treatment of advanced non-small cell lung cancer. Front Immunol. 2021;12:689132.","DOI":"10.3389\/fimmu.2021.689132"},{"key":"8547_CR160","doi-asserted-by":"crossref","unstructured":"Li SQ, Yang Y, Ye LS. Angiogenesis and immune checkpoint dual blockade: opportunities and challenges for hepatocellular carcinoma therapy. World J Gastroentero 2022;28(42):6034\u201344.","DOI":"10.3748\/wjg.v28.i42.6034"},{"key":"8547_CR161","doi-asserted-by":"crossref","unstructured":"Yu P, Wang YR, Yuan DH, Sun YQ, Qin S, Li TY. Vascular normalization: reshaping the tumor microenvironment and augmenting antitumor immunity for ovarian cancer. Front Immunol. 2023;14:1276694.","DOI":"10.3389\/fimmu.2023.1276694"},{"key":"8547_CR162","doi-asserted-by":"crossref","unstructured":"Schmittnaegel M, Rigamonti N, Kadioglu E, Cassar\u00e1 A, Rmili CW, Kiialainen A, Kienast Y, Mueller HJ, Ooi CH, Laoui D, et al. Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci Transl Med. 2017;9(385):eaak9670.","DOI":"10.1126\/scitranslmed.aak9670"},{"key":"8547_CR163","doi-asserted-by":"crossref","unstructured":"Allen E, Jabouille A, Rivera LB, Lodewijckx I, Missiaen R, Steri V, Feyen K, Tawney J, Hanahan D, Michael IP et al. Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med. 2017;9(385):eaak9679.","DOI":"10.1126\/scitranslmed.aak9679"},{"issue":"11","key":"8547_CR164","first-page":"2514","volume":"6","author":"S Du Four","year":"2016","unstructured":"Du Four S, Maenhout SK, Niclou SP, Thielemans K, Neyns B, Aerts JL. Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs. Am J Cancer Res. 2016;6(11):2514\u201331.","journal-title":"Am J Cancer Res"},{"issue":"2","key":"8547_CR165","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1158\/1078-0432.CCR-16-0387","volume":"23","author":"N Horikawa","year":"2017","unstructured":"Horikawa N, Abiko K, Matsumura N, Hamanishi J, Baba T, Yamaguchi K, Yoshioka Y, Koshiyama M, Konishi I. Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells. Clin Cancer Res. 2017;23(2):587\u201399.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"8547_CR166","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/S1470-2045(21)00151-0","volume":"22","author":"PR Galle","year":"2021","unstructured":"Galle PR, Finn RS, Qin SK, Ikeda M, Zhu AX, Kim TY, Kudo M, Breder V, Merle P, Kaseb A, et al. Patient-reported outcomes with atezolizumab plus bevacizumab versus sorafenib in patients with unresectable hepatocellular carcinoma (IMbrave150): an open-label, randomised, phase 3 trial. Lancet Oncol. 2021;22(7):991\u20131001.","journal-title":"Lancet Oncol"},{"issue":"20","key":"8547_CR167","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"RS Finn","year":"2020","unstructured":"Finn RS, Qin SK, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, et al. Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma. New Engl J Med. 2020;382(20):1894\u2013905.","journal-title":"New Engl J Med"},{"issue":"17","key":"8547_CR168","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1097\/CM9.0000000000003231","volume":"137","author":"ZH Guo","year":"2024","unstructured":"Guo ZH, Jing X, Sun XT, Sun SS, Yang YL, Cao YH. Tumor angiogenesis and anti-angiogenic therapy. Chin Med J-Peking. 2024;137(17):2043\u201351.","journal-title":"Chin Med J-Peking"},{"issue":"15","key":"8547_CR169","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1182\/blood.2022018246","volume":"141","author":"L Penter","year":"2023","unstructured":"Penter L, Liu Y, Wolff JO, Yang L, Taing L, Jhaveri A, Southard J, Patel M, Cullen NM, Pfaff KL, et al. Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease. Blood. 2023;141(15):1817\u201330.","journal-title":"Blood"},{"key":"8547_CR170","doi-asserted-by":"crossref","unstructured":"Kovalenko I, Ng WL, Geng YM, Wang YH, Msaouel P, Bhatia S, Grivas P, Benkhadra R, Alhalabi O. Adverse events of immune checkpoint therapy alone versus when combined with vascular endothelial growth factor inhibitors: a pooled meta-analysis of 1735 patients. Front Oncol. 2024;13:1238517.","DOI":"10.3389\/fonc.2023.1238517"},{"key":"8547_CR171","doi-asserted-by":"crossref","unstructured":"Wang L, Wu JQ, Shao P, Bao WP, Mao L, Pan ZD, Bao AH, Zhang M, Wu ZH, Fan GR. An Advanced IVB Lung Adenocarcinoma patient With KRAS Mutations, benefited from camrelizumab combined with anti-angiogenic agents for therapy: a case report. Cancer Rep-Us. 2025;8(6):e70186.","DOI":"10.1002\/cnr2.70186"},{"issue":"4","key":"8547_CR172","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1158\/1078-0432.CCR-20-2500","volume":"27","author":"L Nayak","year":"2021","unstructured":"Nayak L, Molinaro AM, Peters K, Clarke JL, Jordan JT, de Groot J, Nghiemphu L, Kaley T, Colman H, McCluskey C, et al. Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma. Clin Cancer Res. 2021;27(4):1048\u201357.","journal-title":"Clin Cancer Res"},{"key":"8547_CR173","doi-asserted-by":"crossref","unstructured":"Zhang JB, Wang DY, Liu GZ, Bu CJ, Lv GM, Li MH, et al. Dynamic signature for the effectiveness of anti-PD-1 therapy combined with vascular normalization therapy in recurrent glioblastoma: a randomized phase 2 trial. Cancer. 2026;132(2):e70253.","DOI":"10.1002\/cncr.70253"},{"key":"8547_CR174","doi-asserted-by":"crossref","unstructured":"Yang GL, Li H, Yin JB, Yao L, Yang J, Tang JW, et al. Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: a new ally for potentiating anti-PD-L1 blockade of solid Tumor. Ultrason Sonochem. 2025;112:107115.","DOI":"10.1016\/j.ultsonch.2024.107115"},{"key":"8547_CR175","doi-asserted-by":"crossref","unstructured":"Lei LZ, Long J, Chen CG, Zheng BS, Lin X, Fang PY, Chen MF, Jiang XJ, Wang Y, Wang J. Tumor vasculature-mediated formation of tertiary lymphoid structures: unraveling spatiotemporal coupling to optimize vasculo-immunotherapy. Biochem Pharmacol. 2026;244:117574.","DOI":"10.1016\/j.bcp.2025.117574"},{"issue":"7","key":"8547_CR176","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1007\/s00262-023-03422-6","volume":"72","author":"J Cheng","year":"2023","unstructured":"Cheng J, Ge T, Zhu X, Wang J, Zeng Y, Mu W, Cai H, Dai Z, Jin J, Yang Y, et al. Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia. Cancer Immunol Immunother. 2023;72(7):2331\u201346.","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"8547_CR177","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41408-024-01082-y","volume":"14","author":"H Lin","year":"2024","unstructured":"Lin H, Cheng J, Zhu L, Zeng Y, Dai Z, Zhang Y, Zhu X, Mu W. Anti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control. Blood Cancer J. 2024;14(1):98.","journal-title":"Blood Cancer J"},{"issue":"2","key":"8547_CR178","doi-asserted-by":"publisher","first-page":"102584","DOI":"10.1016\/j.xcrm.2026.102584","volume":"7","author":"J Cheng","year":"2026","unstructured":"Cheng J, Zhu L, Wu J, Zeng Y, Mao X, Ding S, Wang J, Xiao Y, Zhou X, Mu W, et al. Efficacy and safety of autologous CD5-KO anti-CD5 CAR-T cells in relapsed\/refractory CD5(+) hematological malignancies. Cell Rep Med. 2026;7(2):102584.","journal-title":"Cell Rep Med"},{"key":"8547_CR179","doi-asserted-by":"crossref","unstructured":"Pasquier J, Ghiabi P, Chouchane L, Razzouk K, Rafii S, Rafii A. Angiocrine endothelium: from physiology to cancer. J Transl Med. 2020;18(1):52.","DOI":"10.1186\/s12967-020-02244-9"},{"key":"8547_CR180","doi-asserted-by":"crossref","unstructured":"Adnani L, Kassouf J, Meehan B, Spinelli C, Tawil N, Nakano I, Rak J. Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells. Nat Commun. 2022;13(1):5494.","DOI":"10.1038\/s41467-022-33235-7"},{"key":"8547_CR181","doi-asserted-by":"crossref","unstructured":"Nakayama A, Roquid KA, Iring A, Strilic B, G\u00fcnther S, Chen M, Weinstein LS, Offermanns S. Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. J Exp Med. 2022;220(1):e20211628.","DOI":"10.1084\/jem.20211628"},{"key":"8547_CR182","doi-asserted-by":"crossref","unstructured":"Ye JZ, Lin Y, Liao ZL, Gao X, Lu C, Lu L, et al. Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma. Npj Precis Oncol. 2024;8(1):262.","DOI":"10.1038\/s41698-024-00752-1"},{"key":"8547_CR183","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.actbio.2018.04.028","volume":"73","author":"C Mazio","year":"2018","unstructured":"Mazio C, Casale C, Imparato G, Urciuolo F, Netti PA. Recapitulating spatiotemporal tumor heterogeneity through engineered breast cancer microtissues. Acta Biomater. 2018;73:236\u201349.","journal-title":"Acta Biomater"},{"issue":"3","key":"8547_CR184","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1161\/ATVBAHA.121.317093","volume":"42","author":"FH Guo","year":"2022","unstructured":"Guo FH, Guan YN, Guo JJ, Zhang LJ, Qiu JJ, Ji Y, Chen AF, Jing Q. Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscl Throm Vas. 2022;42(3):326\u201342.","journal-title":"Arterioscl Throm Vas"},{"key":"8547_CR185","doi-asserted-by":"crossref","unstructured":"Kasurinen JH, Hagstr\u00f6m J, Kaprio T, Jalkanen S, Salmi M, B\u00f6ckelman C, Haglund C. Prognostic values of tissue and serum angiogenic growth factors depend on the phenotypic subtypes of colorectal cancer. Cancers. 2023;15(15):3871.","DOI":"10.3390\/cancers15153871"},{"issue":"2","key":"8547_CR186","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.canlet.2011.05.026","volume":"309","author":"J Lee","year":"2011","unstructured":"Lee J, Lee J, Yu H, Choi K, Choi C. Differential dependency of human cancer cells on vascular endothelial growth factor-mediated autocrine growth and survival. Cancer Lett. 2011;309(2):145\u201350.","journal-title":"Cancer Lett"},{"issue":"8","key":"8547_CR187","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41568-023-00591-5","volume":"23","author":"Q Zeng","year":"2023","unstructured":"Zeng Q, Mousa M, Nadukkandy AS, Franssens L, Alnaqbi H, Alshamsi FY, Safar HA, Carmeliet P. Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer. 2023;23(8):544\u201364.","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"8547_CR188","doi-asserted-by":"publisher","first-page":"H340","DOI":"10.1152\/ajpheart.00352.2025","volume":"329","author":"KK Dalal","year":"2025","unstructured":"Dalal KK, Katari V, Kondapalli N, Paruchuri S, Thodeti CK. Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis. Am J Physiol-Heart C. 2025;329(2):H340\u201357.","journal-title":"Am J Physiol-Heart C"},{"issue":"3","key":"8547_CR189","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ccell.2020.03.002","volume":"37","author":"J Goveia","year":"2020","unstructured":"Goveia J, Rohlenova K, Taverna F, Treps L, Conradi LC, Pircher A, Geldhof V, de Rooij LPMH, Kalucka J, Sokol L, et al. An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates (37, pg 21.e1, 2020). Cancer Cell. 2020;37(3):421\u2013421.","journal-title":"Cancer Cell"},{"key":"8547_CR190","doi-asserted-by":"crossref","unstructured":"Kang TY, Bocci F, Nie Q, Onuchic JN, Levchenko A, Henrion D. Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification. Elife. 2024;12.","DOI":"10.7554\/eLife.89262.3"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08547-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08547-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08547-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:03:39Z","timestamp":1790168619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08547-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":190,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8547"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08547-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests in this section.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1208"}}