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The study was approved by the Peking University Third Hospital Medical Science Research Ethics Committee (approval No. IRB00006761-M2022692). All animal experiments were conducted at Peking University Health Science Center and approved by the Institutional Animal Care and Use Committee of Peking University Health Science Center (Approval number PUIRB-LA2023522). All procedures involving animals were performed in accordance with the Chinese national standard \u201cLaboratory animal\u2014Guideline for ethical review of animal welfare\u201d (GB\/T 35892\u2009\u2212\u20092018), the institutional guidelines for the care and use of laboratory animals, and the internationally recognized 3R principles (Replacement, Reduction, Refinement).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1305"}}