{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:49:12Z","timestamp":1791910152881,"version":"4.3.4"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82273027"],"award-info":[{"award-number":["NSFC82273027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["24YF2704900"],"award-info":[{"award-number":["24YF2704900"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-026-08590-4","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:15:28Z","timestamp":1784135728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Helicobacter pylori promotes hepatocarcinogenesis by abrogating the protective effect of intestinal Bacteroides acidifaciens in females"],"prefix":"10.1186","volume":"24","author":[{"given":"Qiuyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Nian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fansheng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-7673","authenticated-orcid":false,"given":"Ling","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"8590_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41575-024-01021-z","volume":"22","author":"YH Yeo","year":"2025","unstructured":"Yeo YH, Abdelmalek M, Khan S, et al. Current and emerging strategies for the prevention of hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2025;22:173\u201390.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"8590_CR2","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.cgh.2024.08.051","volume":"23","author":"E Koo","year":"2025","unstructured":"Koo E, Seif El Dahan K, Daher D, et al. Risk of Hepatocellular Carcinoma in Subcentimeter Liver Nodules Identified on Surveillance Ultrasound: A Systematic Review. Clin Gastroenterol Hepatol. 2025;23:1320\u2013e13272.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8590_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.cgh.2023.07.029","volume":"22","author":"C Pang","year":"2024","unstructured":"Pang C, Li JM, Wang Z, et al. Age-Dependent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study. Clin Gastroenterol Hepatol. 2024;22:305\u201314.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8590_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3350\/cmh.2024.0545","volume":"31","author":"JS Kim","year":"2025","unstructured":"Kim JS, Kim HS, Tak KY, et al. Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity. Clin Mol Hepatol. 2025;31:509\u201324.","journal-title":"Clin Mol Hepatol"},{"key":"8590_CR5","doi-asserted-by":"crossref","unstructured":"Matz-Soja M, Berg T, Kietzmann T. Sex-related variations in liver homeostasis and disease: From zonation dynamics to clinical implications. J Hepatol. 2025;84.","DOI":"10.1016\/j.jhep.2025.08.007"},{"key":"8590_CR6","doi-asserted-by":"publisher","first-page":"1607374","DOI":"10.3389\/fimmu.2025.1607374","volume":"16","author":"L Song","year":"2025","unstructured":"Song L, Sun L, Ren Y, et al. Sex disparities in hepatocellular carcinoma immunotherapy: hormonal and genetic influences on treatment efficacy. Front Immunol. 2025;16:1607374.","journal-title":"Front Immunol"},{"key":"8590_CR7","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1158\/0008-5472.CAN-23-3966","volume":"84","author":"W He","year":"2024","unstructured":"He W, Wang M, Zhang X, et al. Estrogen Induces LCAT to Maintain Cholesterol Homeostasis and Suppress Hepatocellular Carcinoma Development. Cancer Res. 2024;84:2417\u201331.","journal-title":"Cancer Res"},{"key":"8590_CR8","doi-asserted-by":"publisher","first-page":"2540483","DOI":"10.1080\/19490976.2025.2540483","volume":"17","author":"F Reichardt","year":"2025","unstructured":"Reichardt F, Lucas LN, Okyere L, et al. Portal bile acid composition and microbiota along the murine intestinal tract exhibit sex differences in physiology. Gut Microbes. 2025;17:2540483.","journal-title":"Gut Microbes"},{"key":"8590_CR9","doi-asserted-by":"publisher","first-page":"2528428","DOI":"10.1080\/19490976.2025.2528428","volume":"17","author":"I Choi","year":"2025","unstructured":"Choi I, Kim KA, Kim SC, et al. Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer. Gut Microbes. 2025;17:2528428.","journal-title":"Gut Microbes"},{"key":"8590_CR10","doi-asserted-by":"publisher","first-page":"2450871","DOI":"10.1080\/19490976.2025.2450871","volume":"17","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Wang A, Zhao W, et al. Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity. Gut Microbes. 2025;17:2450871.","journal-title":"Gut Microbes"},{"key":"8590_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.chom.2023.11.011","volume":"32","author":"J Yu","year":"2024","unstructured":"Yu J, Zhu P, Shi L, et al. Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma. Cell Host Microbe. 2024;32:131\u2013e1446.","journal-title":"Cell Host Microbe"},{"key":"8590_CR12","doi-asserted-by":"publisher","first-page":"759306","DOI":"10.3389\/fcimb.2022.759306","volume":"12","author":"L Xue","year":"2022","unstructured":"Xue L, Deng Z, Luo W, et al. Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Front Cell Infect Microbiol. 2022;12:759306.","journal-title":"Front Cell Infect Microbiol"},{"key":"8590_CR13","doi-asserted-by":"publisher","first-page":"108094","DOI":"10.1016\/j.micpath.2025.108094","volume":"209","author":"T Ghaffar","year":"2025","unstructured":"Ghaffar T, Valeriani F, Romano Spica V. The sex related differences in health and Disease: A systematic review of sex-specific gut microbiota and Possible implications for microbial pathogenesis. Microb Pathog. 2025;209:108094.","journal-title":"Microb Pathog"},{"key":"8590_CR14","doi-asserted-by":"publisher","first-page":"e0023625","DOI":"10.1128\/cmr.00236-25","volume":"38","author":"L Tang","year":"2025","unstructured":"Tang L, Xie P, Wang H, et al. The sex hormone-gut microbiome axis: mechanistic drivers of sex-disparate bacterial infection outcomes and precision clinical interventions. Clin Microbiol Rev. 2025;38:e0023625.","journal-title":"Clin Microbiol Rev"},{"key":"8590_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12876-024-03404-7","volume":"24","author":"Y Qiao","year":"2024","unstructured":"Qiao Y, Zhou Y, Zhao L, et al. Sex differences in Helicobacter pylori infection and recurrence rate among 81,754 Chinese adults: a cross-sectional study. BMC Gastroenterol. 2024;24:305.","journal-title":"BMC Gastroenterol"},{"key":"8590_CR16","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1093\/carcin\/bgm150","volume":"28","author":"M Ohtani","year":"2007","unstructured":"Ohtani M, Garcia A, Rogers AB, et al. Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice. Carcinogenesis. 2007;28:2597\u2013604.","journal-title":"Carcinogenesis"},{"key":"8590_CR17","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1093\/carcin\/bgr072","volume":"32","author":"M Ohtani","year":"2011","unstructured":"Ohtani M, Ge Z, Garcia A, et al. 17 beta-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice. Carcinogenesis. 2011;32:1244\u201350.","journal-title":"Carcinogenesis"},{"key":"8590_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1126\/science.abe7199","volume":"371","author":"T Takahashi","year":"2021","unstructured":"Takahashi T, Iwasaki A. Sex differences in immune responses. Science. 2021;371:347\u20138.","journal-title":"Science"},{"key":"8590_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41581-023-00787-w","volume":"20","author":"SE Dunn","year":"2024","unstructured":"Dunn SE, Perry WA, Klein SL. Mechanisms and consequences of sex differences in immune responses. Nat Rev Nephrol. 2024;20:37\u201355.","journal-title":"Nat Rev Nephrol"},{"key":"8590_CR20","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.semcancer.2021.08.007","volume":"86","author":"C Varon","year":"2022","unstructured":"Varon C, Azzi-Martin L, Khalid S, et al. Helicobacters and cancer, not only gastric cancer? Semin Cancer Biol. 2022;86:1138\u201354.","journal-title":"Semin Cancer Biol"},{"key":"8590_CR21","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3109\/00365548.2013.844351","volume":"45","author":"F Wang","year":"2013","unstructured":"Wang F, Liu J, Lv Z. Association of Helicobacter pylori infection with diabetes mellitus and diabetic nephropathy: a meta-analysis of 39 studies involving more than 20,000 participants. Scand J Infect Dis. 2013;45:930\u20138.","journal-title":"Scand J Infect Dis"},{"key":"8590_CR22","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3233\/JAD-160132","volume":"52","author":"T Shindler-Itskovitch","year":"2016","unstructured":"Shindler-Itskovitch T, Ravona-Springer R, Leibovitz A, et al. A Systematic Review and Meta-Analysis of the Association between Helicobacterpylori Infection and Dementia. J Alzheimers Dis. 2016;52:1431\u201342.","journal-title":"J Alzheimers Dis"},{"key":"8590_CR23","doi-asserted-by":"publisher","first-page":"e12967","DOI":"10.1111\/hel.12967","volume":"28","author":"L Sun","year":"2023","unstructured":"Sun L, Zheng H, Qiu M, et al. Helicobacter pylori infection and risk of cardiovascular disease. Helicobacter. 2023;28:e12967.","journal-title":"Helicobacter"},{"key":"8590_CR24","doi-asserted-by":"publisher","first-page":"e12704","DOI":"10.1111\/hel.12704","volume":"25","author":"KI Seo","year":"2020","unstructured":"Seo KI, Heo JJ, Kim SE, et al. Sex differences between Helicobacter pylori infection and cholesterol levels in an adult health checkup program. Helicobacter. 2020;25:e12704.","journal-title":"Helicobacter"},{"key":"8590_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.atherosclerosis.2019.10.005","volume":"291","author":"L Zhang","year":"2019","unstructured":"Zhang L, Chen Z, Xia X, et al. Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males. Atherosclerosis. 2019;291:71\u20137.","journal-title":"Atherosclerosis"},{"key":"8590_CR26","first-page":"149","volume":"130","author":"J Huang","year":"2017","unstructured":"Huang J, Cui J. Evaluation of Helicobacter pylori Infection in Patients with Chronic Hepatic Disease. Chin Med J (Engl). 2017;130:149\u201354.","journal-title":"Chin Med J (Engl)"},{"key":"8590_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13045-020-01028-4","volume":"14","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Hu L, Tang W, et al. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol. 2021;14:9.","journal-title":"J Hematol Oncol"},{"key":"8590_CR28","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1136\/gutjnl-2022-328075","volume":"72","author":"A Ralser","year":"2023","unstructured":"Ralser A, Dietl A, Jarosch S, et al. Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature. Gut. 2023;72:1258\u201370.","journal-title":"Gut"},{"key":"8590_CR29","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1136\/gutjnl-2015-310783","volume":"66","author":"R Mejias-Luque","year":"2017","unstructured":"Mejias-Luque R, Zoller J, Anderl F, et al. Lymphotoxin beta receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner. Gut. 2017;66:1369\u201381.","journal-title":"Gut"},{"key":"8590_CR30","doi-asserted-by":"publisher","first-page":"e70487","DOI":"10.1371\/journal.pone.0070487","volume":"8","author":"RK Sodhi","year":"2013","unstructured":"Sodhi RK, Singh N. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS ONE. 2013;8:e70487.","journal-title":"PLoS ONE"},{"key":"8590_CR31","doi-asserted-by":"crossref","unstructured":"Luo P, Huang Y, Hang X, Tong Q, Zeng L, Jia J, Zhang G, Bi H. Dihydrotanshinone I is effective against drug-resistant Helicobacter pylori in vitro and in vivo. Antimicrob Agents Chemother. 2021;65.","DOI":"10.1128\/AAC.01921-20"},{"key":"8590_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ijid.2016.07.014","volume":"50","author":"J Wang","year":"2016","unstructured":"Wang J, Chen RC, Zheng YX, et al. Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis. Int J Infect Dis. 2016;50:30\u20137.","journal-title":"Int J Infect Dis"},{"key":"8590_CR33","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.3748\/wjg.v24.i32.3617","volume":"24","author":"K Okushin","year":"2018","unstructured":"Okushin K, Tsutsumi T, Ikeuchi K, et al. Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis. World J Gastroenterol. 2018;24:3617\u201325.","journal-title":"World J Gastroenterol"},{"key":"8590_CR34","doi-asserted-by":"publisher","first-page":"108273","DOI":"10.1016\/j.micpath.2025.108273","volume":"211","author":"G Singh","year":"2026","unstructured":"Singh G, Ansari S, Yadav S, et al. Gut microbiota\u2019s role in NAFLD- and HBV\/HCV-related hepatocellular carcinoma: Mechanisms and therapeutic implications. Microb Pathog. 2026;211:108273.","journal-title":"Microb Pathog"},{"key":"8590_CR35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1146\/annurev-physiol-031522-092054","volume":"85","author":"BK Perler","year":"2023","unstructured":"Perler BK, Friedman ES, Wu GD. The Role of the Gut Microbiota in the Relationship Between Diet and Human Health. Annu Rev Physiol. 2023;85:449\u201368.","journal-title":"Annu Rev Physiol"},{"key":"8590_CR36","doi-asserted-by":"publisher","first-page":"e1260","DOI":"10.1002\/mbo3.1260","volume":"11","author":"DV Patangia","year":"2022","unstructured":"Patangia DV, Anthony Ryan C, Dempsey E, et al. Impact of antibiotics on the human microbiome and consequences for host health. Microbiologyopen. 2022;11:e1260.","journal-title":"Microbiologyopen"},{"key":"8590_CR37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41522-024-00564-y","volume":"10","author":"N Oguri","year":"2024","unstructured":"Oguri N, Miyoshi J, Nishinarita Y, et al. Akkermansia muciniphila in the small intestine improves liver fibrosis in a murine liver cirrhosis model. NPJ Biofilms Microbiomes. 2024;10:81.","journal-title":"NPJ Biofilms Microbiomes"},{"key":"8590_CR38","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/s41467-023-37459-z","volume":"14","author":"Q Zhao","year":"2023","unstructured":"Zhao Q, Dai MY, Huang RY, et al. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nat Commun. 2023;14:1829.","journal-title":"Nat Commun"},{"key":"8590_CR39","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","volume":"32","author":"H Shen","year":"2024","unstructured":"Shen H, Zhou L, Zhang H, et al. Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification. Cell Host Microbe. 2024;32:1331\u2013e13466.","journal-title":"Cell Host Microbe"},{"key":"8590_CR40","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.redox.2014.01.012","volume":"2","author":"F Jiang","year":"2014","unstructured":"Jiang F, Liu GS, Dusting GJ, et al. NADPH oxidase-dependent redox signaling in TGF-\u03b2-mediated fibrotic responses. Redox Biol. 2014;2:267\u201372.","journal-title":"Redox Biol"},{"key":"8590_CR41","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41586-019-1897-5","volume":"577","author":"J Su","year":"2020","unstructured":"Su J, Morgani SM, David CJ, et al. TGF-\u03b2 orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature. 2020;577:566\u201371.","journal-title":"Nature"},{"key":"8590_CR42","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12943-022-01495-y","volume":"21","author":"L Zheng","year":"2022","unstructured":"Zheng L, Liang H, Zhang Q, et al. circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-\u03b2\/Smad signaling. Mol Cancer. 2022;21:41.","journal-title":"Mol Cancer"},{"key":"8590_CR43","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1002\/cac2.12235","volume":"41","author":"VR Silva","year":"2021","unstructured":"Silva VR, Santos LS, Dias RB, et al. Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells. Cancer Commun (Lond). 2021;41:1275\u2013313.","journal-title":"Cancer Commun (Lond)"},{"key":"8590_CR44","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12943-024-02038-3","volume":"23","author":"M Wang","year":"2024","unstructured":"Wang M, Ding X, Fang X, et al. Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p\/TXNIP axis. Mol Cancer. 2024;23:128.","journal-title":"Mol Cancer"},{"key":"8590_CR45","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.prp.2013.11.003","volume":"210","author":"E Rabelo-Gon\u00e7alves","year":"2014","unstructured":"Rabelo-Gon\u00e7alves E, Roesler B, Guardia AC, et al. Evaluation of five DNA extraction methods for detection of H. pylori in formalin-fixed paraffin-embedded (FFPE) liver tissue from patients with hepatocellular carcinoma. Pathol Res Pract. 2014;210:142\u20136.","journal-title":"Pathol Res Pract"},{"key":"8590_CR46","doi-asserted-by":"publisher","first-page":"451","DOI":"10.11622\/smedj.2013153","volume":"54","author":"J Yang","year":"2013","unstructured":"Yang J, Ji S, Zhang Y, et al. Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue. Singap Med J. 2013;54:451\u20137.","journal-title":"Singap Med J"},{"key":"8590_CR47","doi-asserted-by":"publisher","first-page":"1582131","DOI":"10.3389\/fcimb.2025.1582131","volume":"15","author":"J Zhang","year":"2025","unstructured":"Zhang J, Liu S, Zhang J, et al. Helicobacter pylori induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway. Front Cell Infect Microbiol. 2025;15:1582131.","journal-title":"Front Cell Infect Microbiol"},{"key":"8590_CR48","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1159\/000542847","volume":"106","author":"N Ben Khaled","year":"2025","unstructured":"Ben Khaled N, Schulz C, Alunni-Fabbroni M, et al. Impact of Helicobacter pylori on Immune Checkpoint Inhibition in Hepatocellular Carcinoma: A Multicenter Study. Digestion. 2025;106:303\u201313.","journal-title":"Digestion"},{"key":"8590_CR49","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/10799893.2024.2436461","volume":"44","author":"Z Mohammadi Azad","year":"2024","unstructured":"Mohammadi Azad Z, Moosazadeh Moghaddam M, Fasihi-Ramandi M, et al. Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-\u03b2\/SMAD signaling pathway in hepatocellular carcinoma. J Recept Signal Transduct Res. 2024;44:181\u201390.","journal-title":"J Recept Signal Transduct Res"},{"key":"8590_CR50","doi-asserted-by":"publisher","first-page":"e2401059","DOI":"10.1002\/smll.202401059","volume":"20","author":"Y Tong","year":"2024","unstructured":"Tong Y, Liu Q, Fu H, et al. Cascaded Nanozyme Based pH-Responsive Oxygenation for Targeted Eradication of Resistant Helicobacter Pylori. Small. 2024;20:e2401059.","journal-title":"Small"},{"key":"8590_CR51","doi-asserted-by":"publisher","first-page":"2519703","DOI":"10.1080\/19490976.2025.2519703","volume":"17","author":"V Arr\u00e8","year":"2025","unstructured":"Arr\u00e8 V, De Luca R, Mrmi\u0107 S, et al. Gastrointestinal inflammation and cancer: viral and bacterial interplay. Gut Microbes. 2025;17:2519703.","journal-title":"Gut Microbes"},{"key":"8590_CR52","doi-asserted-by":"publisher","first-page":"101277","DOI":"10.1016\/j.drup.2025.101277","volume":"83","author":"QQ Chai","year":"2025","unstructured":"Chai QQ, Li D, Zhang M, et al. Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance. Drug Resist Updat. 2025;83:101277.","journal-title":"Drug Resist Updat"},{"key":"8590_CR53","first-page":"100880","volume":"6","author":"R Mejias-Luque","year":"2025","unstructured":"Mejias-Luque R, Gerhard M. Decoding the interplay: Helicobacter pylori infection, tumor immune microenvironment, and immunotherapy outcomes in gastrointestinal cancers. Innov (Camb). 2025;6:100880.","journal-title":"Innov (Camb)"},{"key":"8590_CR54","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1152\/physiolgenomics.00184.2025","volume":"57","author":"TB Scheidl","year":"2025","unstructured":"Scheidl TB, Wager JL, Shearer J, et al. Cross talk between obesogenic diet and estrogen drives distinct microbiota profiles in ovariectomized mice. Physiol Genomics. 2025;57:734\u201343.","journal-title":"Physiol Genomics"},{"key":"8590_CR55","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.str.2017.05.003","volume":"25","author":"RM Pollet","year":"2017","unstructured":"Pollet RM, D\u2019Agostino EH, Walton WG, et al. An Atlas of beta-Glucuronidases in the Human Intestinal Microbiome. Structure. 2017;25:967\u201377. e5.","journal-title":"Structure"},{"key":"8590_CR56","doi-asserted-by":"publisher","first-page":"9291","DOI":"10.1038\/s41467-024-53144-1","volume":"15","author":"Y Wu","year":"2024","unstructured":"Wu Y, Zhang X, Liu X, et al. Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis. Nat Commun. 2024;15:9291.","journal-title":"Nat Commun"},{"key":"8590_CR57","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1016\/j.cmet.2024.08.002","volume":"36","author":"VA Petrov","year":"2024","unstructured":"Petrov VA, Laczny CC, Wilmes P. Bacteroides acidifaciens: Linking dietary fiber to liver health. Cell Metab. 2024;36:1908\u201310.","journal-title":"Cell Metab"},{"key":"8590_CR58","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1038\/s42255-025-01356-0","volume":"7","author":"S Jung","year":"2025","unstructured":"Jung S, Bae H, Song WS, et al. Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis. Nat Metab. 2025;7:1801\u201318.","journal-title":"Nat Metab"},{"key":"8590_CR59","doi-asserted-by":"publisher","first-page":"116266","DOI":"10.1016\/j.jpba.2024.116266","volume":"248","author":"T Ma","year":"2024","unstructured":"Ma T, Chen P, Dong H, et al. Identification of key anti-neuroinflammatory components in Gastrodiae Rhizoma based on spectrum-effect relationships and its mechanism exploration. J Pharm Biomed Anal. 2024;248:116266.","journal-title":"J Pharm Biomed Anal"},{"key":"8590_CR60","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1186\/s12951-025-03578-6","volume":"23","author":"Z Lu","year":"2025","unstructured":"Lu Z, Chai Q, Dai W, et al. Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction. J Nanobiotechnol. 2025;23:496.","journal-title":"J Nanobiotechnol"},{"key":"8590_CR61","doi-asserted-by":"publisher","first-page":"120094","DOI":"10.1016\/j.jep.2025.120094","volume":"352","author":"D Guan","year":"2025","unstructured":"Guan D, Wang M, Zhang M, et al. Exploring the potential protective mechanism of Gastrodia elata Blume in Parkinson\u2019s disease using LC-MS\/MS-based striatal metabolomics. J Ethnopharmacol. 2025;352:120094.","journal-title":"J Ethnopharmacol"},{"key":"8590_CR62","doi-asserted-by":"crossref","unstructured":"Xiao T, Yu X, Tao J, Yang L, Duan X. Metabolomics-based study of the protective effect of 4-hydroxybenzyl alcohol on ischemic astrocytes. Int J Mol Sci. 2024;25.","DOI":"10.3390\/ijms25189907"},{"key":"8590_CR63","doi-asserted-by":"publisher","first-page":"111593","DOI":"10.1016\/j.intimp.2024.111593","volume":"129","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Wu H, Peng Y, et al. Gastrodin ameliorates acute pancreatitis by modulating macrophage inflammation cascade via inhibition the p38\/NF-\u03baB pathway. Int Immunopharmacol. 2024;129:111593.","journal-title":"Int Immunopharmacol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-026-08590-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08590-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-026-08590-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:05:56Z","timestamp":1791907556000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-026-08590-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8590"],"URL":"https:\/\/doi.org\/10.1186\/s12967-026-08590-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"8 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study received approval from the Ethics Committee of Zhongshan Hospital, affiliated with Fudan University (Approval No. B2025-442). All experiments involving human participants were conducted in compliance with the principles outlined in the Declaration of Helsinki. Clinical trial number: not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflict of interest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1288"}}